Engineering Commons^™

Microencapsulation Of A Connexin-43 Mimetic Peptide As A Novel Wound Healing Agent In An Ocular Injury Model, Keith Brian Moore

Theses and Dissertations

Corneal transplantation and related surgical procedures are areas of tissue replacement which have seen promising advances. Currently, cornea transplants are one of the most common surgical procedures, with approximately 40,000 occurring each year in the United States. Still, problems exist with a 20% rejection rate, post surgical infections, and the need for a constant supply of donors. The ability to safely and quickly heal and regenerate corneal epithelia fills an area of advancement in regenerative medicine, with implications reaching beyond the scope of vision therapies toward healing of a wide range of tissues and wounds. In vivo corneal wounds were …