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Biomedical Engineering and Bioengineering

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Articles 9691 - 9720 of 11446

Full-Text Articles in Engineering

A Novel Method For Characterization Of Peripheral Nerve Fiber Size Distributions By Group Delay Measurements And Simulated Annealing Optimization, Robert B. Szlavik, Galen E. Turner, Iii Aug 2008

A Novel Method For Characterization Of Peripheral Nerve Fiber Size Distributions By Group Delay Measurements And Simulated Annealing Optimization, Robert B. Szlavik, Galen E. Turner, Iii

Biomedical Engineering

The ability to determine the characteristics of peripheral nerve fiber size distributions would provide additional information to clinicians for the diagnosis of specific pathologies of the peripheral nervous system. Investigation of these conditions, using electro-diagnostic techniques, is advantageous in the sense that such techniques tend to be minimally invasive yet provide valuable diagnostic information. One of the principal electro-diagnostic tools available to the clinician is the nerve conduction velocity test. While the peripheral nerve conduction velocity test can provide useful information to the clinician regarding the viability of the nerve under study, it is a single parameter test that yields …

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Engineered Micro-Environments And Vibrational Culture Systems For Vocal Fold Tissue Engineering, Jaishankar Kutty Aug 2008

Engineered Micro-Environments And Vibrational Culture Systems For Vocal Fold Tissue Engineering, Jaishankar Kutty

All Dissertations

Voice is produced by the conversion of aerodynamic energy from exhalation to acoustical energy for voice production by the vocal folds (membranous connective tissue) located in the larynx. The quality of voice depends on the biomechanical properties of the multi-layered vocal fold tissue which derive from its extracellular matrix (ECM) organization and composition. The wound healing response to vocal fold injuries is characterized by scarring and subsequent dysphonia due to alterations in the biomechanical properties of the tissue.
The work presented here is motivated by the importance of voice in maintaining quality of life and the inability of current treatment …

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Cues For Cellular Assembly Of Vascular Elastin Networks, Chandrasekhar Kothapalli Aug 2008

Cues For Cellular Assembly Of Vascular Elastin Networks, Chandrasekhar Kothapalli

All Dissertations

Elastin, a structural protein distributed in the extracellular matrix of vascular tissues is critical to the maintenance of vascular mechanics, besides regulation of cell-signaling pathways involved in injury response and morphogenesis. Thus, congenital absence or disease-mediated degradation of vascular elastin and its malformation within native vessels due to innately poor elastin synthesis by adult vascular cells compromise vascular homeostasis. Current elastin regenerative strategies using tissue engineering principles are limited by the progressive destabilization of tropoelastin mRNA expression in adult vascular cells and the unavailability of scaffolds that can provide cellular cues necessary to up-regulate elastin synthesis and regenerate faithful mimics …

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Chitosan Derivatives For Tissue Engineering, Yongzhi Qiu Aug 2008

Chitosan Derivatives For Tissue Engineering, Yongzhi Qiu

All Dissertations

Chitosan, a naturally occurring polysaccharide, and its derivatives have been widely explored for biomedical applications due to their biocompatibility and biodegradability. In our studies, we developed a series of chitosan derivatives through chemical modifications. These chitosan derivatives not only possess better processibility in scaffolds fabrication, but also show excellent potentials in tissue engineering applications, including blood vessel and bone tissue engineering.
The excellent antithrombogenic property is crucial for vascular engineering applications, especially in engineering small-diameter blood vessels. In our studies, chitosan was chemically modified by phthalization and the phthalized chitosan exhibited great antithrombogenic property. Through a wet- phase-inversion process, tubular …

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The Spaceflight Environment And The Skeletal System, Eric Bandstra Aug 2008

The Spaceflight Environment And The Skeletal System, Eric Bandstra

All Dissertations

The spaceflight environment presents many challenges to the human body. Bone loss in astronauts is a well known consequence of reduced loading in the weightless environment of low-earth orbit. Recent studies have also indicated that spaceflight relevant types of radiation (at relatively high doses) have deleterious effects on trabecular bone. Both of these represent potential skeletal challenges during long-duration spaceflight. The objective of these studies is to examine the response of bone to models of the spaceflight environment.
Astronauts will likely absorb doses of protons and heavy ions during lengthy missions outside the Earth's magnetosphere. Following exposure to a range …

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Image-Guided Raman Spectroscopic Recovery Of Canine Cortical Bone Contrast In Situ, Subhadra Srinivasan, Matthew Schulmerich, Jacqueline H. Cole, Kathryn Dooley, Jaclynn M. Kreider, Brian W. Pogue Aug 2008

Image-Guided Raman Spectroscopic Recovery Of Canine Cortical Bone Contrast In Situ, Subhadra Srinivasan, Matthew Schulmerich, Jacqueline H. Cole, Kathryn Dooley, Jaclynn M. Kreider, Brian W. Pogue

Dartmouth Scholarship

Raman scattering provides valuable biochemical and molecular markers for studying bone tissue composition with use in predicting fracture risk in osteoporosis. Raman tomography can image through a few centimeters of tissue but is limited by low spatial resolution. X-ray computed tomography (CT) imaging can provide high-resolution image-guidance of the Raman spectroscopic characterization, which enhances the quantitative recovery of the Raman signals, and this technique provides additional information to standard imaging methods. This hypothesis was tested in data measured from Teflon tissue phantoms and from a canine limb. Image-guided Raman spectroscopy (IG-RS) of the canine limb using CT images of the …

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Department Of Biological Systems Engineering Newsletter, Volume 4, Number 1, August 2008 Aug 2008

Department Of Biological Systems Engineering Newsletter, Volume 4, Number 1, August 2008

BSE Department Magazine

Contents:
New Biomedical Lab Makes Debut
From the Department Head
The Dean's List
Meet the Faculty
Alumni News
Student News
UCARE
Graduates
John Miller: A Success Story
Discover Your Career: Mechanized Systems Management
Alumnus Profile
Faculty and Staff News
Comings and Goings
Spreading the word about No-till

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Targeted Drug Delivery To Human Aortic Smooth Muscle Cells Using Biodegradable Nanoparticles, Danyel Specht Aug 2008

Targeted Drug Delivery To Human Aortic Smooth Muscle Cells Using Biodegradable Nanoparticles, Danyel Specht

Bioengineering Theses - Archive

Restenosis is a common problem that can occur in angioplasty patients. In order to reduce the restentosis rate, various treatments such as glucocorticoids and drug eluting stents have been used for angioplasty patients. However, their limitations include the inefficient delivery of drugs to inhibit smooth muscle cell proliferation, a major cause of restenosis. Therefore, we propose the use of biodegradable nanoparticles as a drug delivery system for transporting a therapeutic agent to human aortic smooth muscle cells (HASMC) to prevent their proliferation. In this study the glucocorticoid dexamethasone (DEX) was chosen as the therapeutic agent. A biodegradable polymer, poly (D,Llactide-co-glycolide) …

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Subcellular Light Activation, Control And Manipulation Using A Dynamically Reconfigurable Nanopatterning System, Amruta Rajiv Joshi Aug 2008

Subcellular Light Activation, Control And Manipulation Using A Dynamically Reconfigurable Nanopatterning System, Amruta Rajiv Joshi

Bioengineering Theses - Archive

Cellular communication is the basis of all cellular activities and functions. Cell signaling is crucial in the processes of tissue maintenance, tissue development and homeostasis. Errors in transmission or interpretation of these signals can result in the onset of diseases like cancer. Efforts have been made to probe into the communication between cells, and the extracellular signals that cells transmit to each other. There is however, a necessity to understand cell communication within the cellular components themselves and to be able to perform a nanoscale analysis of the cell organelle behavior. Many cellular mechanisms involve processes at the subcellular level, …

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Microfluidic Flow Cytometer For High Throughput Label Free Cell Analysis, Sajal Chirvi Aug 2008

Microfluidic Flow Cytometer For High Throughput Label Free Cell Analysis, Sajal Chirvi

Bioengineering Theses - Archive

Microfluidic flow cytometer for high throughput label free cell analysis is proposed. Detection of cell morphology plays an important role in determination of state of health and diagnosis of many diseases such as sickle cell anemia, cancer, urine analysis, blood analysis etc. The platform proposed integrates label free cell analysis, microfluidic platform and high throughput imaging. Label free analysis helps in analyzing cells without altering cell/protein of interest and also allows biophysical characterization of living cells. Microfluidic platform used is fabricated from soft lithography. It mimics biological environment due to its channel confinement and is biocompatible. Being optically clear (PDMS), …

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Cytotoxicity Evaluation Of Temperature Sensitive Poly(N-Isopropylacrylamide) Nanoparticles For Drug Delivery, Aniket Sharadrao Wadajkar Aug 2008

Cytotoxicity Evaluation Of Temperature Sensitive Poly(N-Isopropylacrylamide) Nanoparticles For Drug Delivery, Aniket Sharadrao Wadajkar

Bioengineering Theses - Archive

The objective of this research project was to develop temperature sensitive poly(N-isopropylacrylamide) (PNIPA) nanoparticles for drug delivery applications. These nanoparticles were formulated by a radical polymerization method, and their toxicity was studied in vitro using MTS assays and various cell types such as fibroblasts, smooth muscle cells, and endothelial cells. Cytotoxicity results did not show a significant difference in cell survival when cells were exposed to different particle sizes (100, 300, and 500 nm). In addition, dose studies of 100 nm nanoparticles showed that the cells exposed to PNIPA nanoparticles at concentrations less than or equal to 5 mg/ml were …

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Exploratory Study Of Gold Nanoshell As A Therapeutic Thermal Ablation Agent For Cancer Treatment Using Laboratory And Animal Tissue Phantoms, Yajuvendra Rathore Aug 2008

Exploratory Study Of Gold Nanoshell As A Therapeutic Thermal Ablation Agent For Cancer Treatment Using Laboratory And Animal Tissue Phantoms, Yajuvendra Rathore

Bioengineering Theses - Archive

Prostate cancer is the most common male cancer in the United States and the second leading cause of male death from cancer. Surgical removal of the prostate is associated with high risks of surgical complications and consequences such as incontinence and sexual dysfunction. In my study, I have investigated a nanoparticle-assisted photothermal therapeutic method that may be used for treatment of prostate cancer in the future. This method is minimally-invasive and uses gold nano-shells as hyperthermia agents to treat localized necrosis of cancer cells. I have conducted a feasibility study for a new class of NIR absorbing nanoparticles called Gold …

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Study Of Normobaric Hyperoxia Effects During Focal Hypoxia-Ischemic Injury In Mice Using Optical Spectroscopy Measurements, Shereen Mohideen Aug 2008

Study Of Normobaric Hyperoxia Effects During Focal Hypoxia-Ischemic Injury In Mice Using Optical Spectroscopy Measurements, Shereen Mohideen

Bioengineering Theses - Archive

Optical spectroscopy has seen tremendous growth and development in recent years and has been extensively used to characterize the optical properties of biological tissues. The purpose of this study is to investigate the values of oxygen saturation and concentration of hemoglobin in mice with focal hypoxic ischemia after being recovered in normobaric hyperoxia. Mice at five different age levels were used for this purpose, in order to see the effects of hyperoxia at different developmental stages of the brain; ischemia was induced in them by ligating their right carotid artery and subjecting them to hypoxic (8% oxygen) environment for half …

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Model Driven Analysis Of Optical Reflectance Spectroscopy For Detection Of Human Prostate And Kidney Cancers, Aditya Vivek Mathker Aug 2008

Model Driven Analysis Of Optical Reflectance Spectroscopy For Detection Of Human Prostate And Kidney Cancers, Aditya Vivek Mathker

Bioengineering Theses - Archive

Renal cell carcinoma is one of the most common forms of kidney cancer originating from the renal tubule. During surgery, it is difficult for the surgeons to identify the cancer tissue from the normal tissue and also the benign tumor from malignant tumor. Moreover, prostate cancer is the leading cause of death amongst men in the United States. In this study, optical reflectance spectroscopy with short source-detector separation is used as a minimally invasive technique to differentiate normal tissues from tumor lesions and also to differentiate benign from malignant tissues in renal cell carcinoma. Clinical post-operative readings were obtained using …

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Comparison Of Hemodynamic Response Non-Linearity Using Simultaneous Functional Near Infrared Spectrsoscopy And Magnetic Resonance Imaging Modalities, Renuka Parlapalli Aug 2008

Comparison Of Hemodynamic Response Non-Linearity Using Simultaneous Functional Near Infrared Spectrsoscopy And Magnetic Resonance Imaging Modalities, Renuka Parlapalli

Bioengineering Theses - Archive

Blood oxygenation level dependent (BOLD) response, which is measured by functional magnetic resonance imaging (fMRI), is known to be a combination of various vascular parameters, among which deoxy-hemoglobin is argued to be a major contributor. Functional near infrared spectroscopy (fNIRS) though limited in its spatial resolution provides a promising tool to study cortical activations, due to its specificity of independent measurement of blood parameters (Oxy, De-oxy and Total Hemoglobin), high temporal resolution and ease of use. To integrate the best aspects of two imaging modalities, it becomes important to study the close relationship between the two imaging modalities. A finger …

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Surgical Fluorescence Imager For Visualizing Anteriorly Placed Biliary Structures, In-Vivo During Human Cholecystectomy, Santosh Hariharan Aug 2008

Surgical Fluorescence Imager For Visualizing Anteriorly Placed Biliary Structures, In-Vivo During Human Cholecystectomy, Santosh Hariharan

Bioengineering Theses - Archive

Cholecystectomy is one of the most common procedures occurring in United States to cure gall bladder diseases. There are two means of performing this procedure, Open Cholecystectomy and Laparoscopic Cholecystectomy, the later one being more frequent. The critical issue while performing Cholecystectomy is injury to Common Bile Duct (CBD) which could cause post procedural complications. Since the CBD is under fat layer it is important to image and locate the CBD during the procedure. The novel fluorescence imager developed in this project would help visualize the CBD by using the fluorescence properties of Indocyanine Green, to be injected into the …

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Study Of Nirs Based Motor Cortex Activation Patterns In Cerebral Palsy Affected Kids Using Image Based Metrics, Nayan Jaikrishna Asanani Aug 2008

Study Of Nirs Based Motor Cortex Activation Patterns In Cerebral Palsy Affected Kids Using Image Based Metrics, Nayan Jaikrishna Asanani

Bioengineering Theses - Archive

In recent years the National Institutes of Health has placed great emphasis on addressing the emergent need to accelerate translation of laboratory discoveries into clinical practice. The proposed study is very much aligned with this NIH emphasis, targeting on the translation of near infrared (NIR) brain imaging to clinical assessment for children with cerebral palsy. Over ten million Americans are affected by central nervous system disorders that result in motor deficits. Cerebral palsy (CP) is the most common motor disorder of central origin in childhood and affects at least 2 children per 1000 live births every year . One of …

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Influence Of Hypoxia, Hypercapnia And Inspiratory Efforts On Sympathoexcitation During Apnea, Vikram Rao Aug 2008

Influence Of Hypoxia, Hypercapnia And Inspiratory Efforts On Sympathoexcitation During Apnea, Vikram Rao

Bioengineering Theses - Archive

Obstructive Sleep Apnea (OSA) is characterized by frequent periods of apnea resulting in hypoxia, hypercapnia and fluctuations of intrathoracic pressure (inspiratory efforts). Hypoxia, hypercapnia and inspiratory efforts lead to stimulation of peripheral chemoreceptors, central chemoreceptors and baroreceptors, respectively, which in turn influence Muscle Sympathetic Nerve Activity (MSNA). We hypothesized that hypoxia and hypercapnia result in an elevated MSNA response, while inspiratory efforts result in a reduced MSNA response during apnea. To test the hypothesis, we determined the contributions of hypoxia (at 12% O2), hypercapnia (at 3% CO2) and inspiratory efforts (mueller maneuvers at 20 mmHg) to MSNA (using microneurographic techniques) …

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A Novel Approach For Mri Image Classification And Image Retrieval, Ankit Vinod Master Aug 2008

A Novel Approach For Mri Image Classification And Image Retrieval, Ankit Vinod Master

Bioengineering Theses - Archive

OBJECTIVE: Classification of MRI image data based on its attribute characteristics is very important for storing the image data and its efficient retrieval. This project aims to find a solution to the problem of classification of the images that are stored on a hard drive and image retrieval from the image database with optimum automation in a user friendly way. METHOD: Matlab was used to create a software tool for image classification and, Java and SQL were used to create a software tool for image retrieval. RESULTS: Image classification tool could read multiple files, extract attribute values from the files …

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A Design Aid For Determining Width Of Filter Strips, Michael G. Dosskey, M. J. Helmers, Dean E. Eisenhauer Aug 2008

A Design Aid For Determining Width Of Filter Strips, Michael G. Dosskey, M. J. Helmers, Dean E. Eisenhauer

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Watershed planners need a tool for determining width of filter strips that is accurate enough for developing cost-effective site designs and easy enough to use for making quick determinations on a large number and variety of sites. This study employed the process-based Vegetative Filter Strip Model to evaluate the relationship between filter strip width and trap¬ping efficiency for sediment and water and to produce a design aid for use where specific water quality targets must be met. Model simulations illustrate that relatively narrow filter strips can have high impact in some situations, while in others even a modest impact cannot …

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Preparing, Characterizing, On-Line Digital Image Processing Of Residence Time Distribution And Modeling Of Mechanical Properties Of Nanocomposite Foams, Siew-Yoong Lee Jul 2008

Preparing, Characterizing, On-Line Digital Image Processing Of Residence Time Distribution And Modeling Of Mechanical Properties Of Nanocomposite Foams, Siew-Yoong Lee

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

The objectives of this research were to prepare, characterize and to study the effects of organoclay and extrusion variables on the physical, mechanical, structural, thermal and functional properties of tapioca starch (TS)/poly(lactic acid) (PLA) nanocomposite foams. On-line digital imaging processing was used to determine residence time distribution (RTD). Adaptive neuro-fuzzy inference system (ANFIS) was used to model the mechanical properties of nanocomposite foams.

Four different organoclays (Cloisite 10A, 25A, 93A, 15A) were used to produce nanocomposite foams by melt-intercalation. The properties were characterized using Xray diffraction, scanning electron microscopy, differential scanning calorimetric, and Instron universal testing machine. The properties were …

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Synthesis And Characterization Of Polyionic Hydrogels, Pooja Desai Jul 2008

Synthesis And Characterization Of Polyionic Hydrogels, Pooja Desai

Theses and Dissertations

In this study we describe novel polyionic dendrimer – PEG hydrogels for drug delivery. Hydrogels have a crosslinked insoluble network of polymer chains, which have found many applications including drug delivery and tissue regeneration. Dendrimers provide an ideal platform for drug delivery as they possess a well-defined highly branched nanoscale architecture with many reactive surface groups. Their highly clustered surface groups allow for targeted drug delivery and high drug payload to enhance therapeutic effectiveness. This study presented a new type of polyionic hydrogels based on dendrimers with potential applications in drug delivery and tissue engineering. Polyethylene glycol (PEG) with various …

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Assessment Of Fifth Metatarsal Etiology, Daniel Reed Jul 2008

Assessment Of Fifth Metatarsal Etiology, Daniel Reed

All Theses

The fifth metatarsal 'Jones Fracture' is a fracture that occurs 3.5cm distal to the tuberosity. It is an injury that is common in athletes, especially those who participate in sports with a lot of lateral movement. The Jones Fracture is known for its difficulty to heal due to non-union and re-fracture. There has been much research recently regarding in-shoe pressure distributions and their relation to shoe type, movement, and shoe surface interaction. However, only the forces along the bottom of the foot have been investigated. Literature and the direction of fracture seem to implicate a force on the lateral portion …

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Risedronate Prevents Early Bone Loss Resulting From Whole-Body Irradiation, Eric Livingston Jul 2008

Risedronate Prevents Early Bone Loss Resulting From Whole-Body Irradiation, Eric Livingston

All Theses

Osteoporosis is a condition characterized by a reduction in bone strength resulting in an overall increase in the risk of fracture. There are many factors that contribute to the development of this condition, including ionizing radiation exposure. Declines in bone volume and trabecular micro-architecture have been found following exposure to multiple types of radiation. Past research has implicated reduction of osteoblast function and changes to vasculature as the primary sources of bone deterioration. Recently, an early increase in osteoclast number was observed following exposure to low-energy X-rays, identifying an increase in resorption as a possible cause and potential target for …

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Biomechanical Evaluation Of Two Methods Of Humeral Shaft Fixation, Joshua Catanzarite Jul 2008

Biomechanical Evaluation Of Two Methods Of Humeral Shaft Fixation, Joshua Catanzarite

All Theses

Biomechanical evaluations of fracture fixation devices attempt to determine implant performance by approximating the in vivo conditions. This performance is affected by many factors and relies on the complex bone-implant interface. Biomechanical tests can be designed in a variety of ways in order to evaluate device performance with respect to any number of these bone-implant interactions. Standardized tests, designed by groups such as the American Society for Testing and Materials (ASTM), are often designed either to determine the performance of a specific type of fixation device or for direct comparison between different devices. Additionally, many biomechanical evaluations are designed for …

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Quantifying Antalgic Gait Knee Function Using Inertial Sensor Technology, William Mostertz Jul 2008

Quantifying Antalgic Gait Knee Function Using Inertial Sensor Technology, William Mostertz

All Theses

The use of body-fixed inertial sensors to analyze human movement may prove useful in the medical field. Improving orthopaedic device design, diagnosing musculoskeletal disorders, and rehabilitation assessment could all benefit from a mobile gait analysis system based on inertial sensors. More specifically, patients recovering from lower limb corrective surgeries tend to adjust gait patterns to accommodate pain, a condition referred to as antalgic gait. Currently there is no quantitative method available to assess recovery for this patient population during post-operative management. A comparison of the inertial sensor system with the camera-based industry standard has confirmed it as a viable method …

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Effects Of Narrow Grass Hedges On Nutrient Transport From Land Application Areas, John E. Gilley, Bahman Eghball, David B. Marx Jul 2008

Effects Of Narrow Grass Hedges On Nutrient Transport From Land Application Areas, John E. Gilley, Bahman Eghball, David B. Marx

Department of Agricultural and Biological Systems Engineering: Presentations and White Papers

The placement of stiff-stemmed grass hedges on the contour along a hill slope has been shown to decrease runoff nutrient transport. This study was conducted to measure the effectiveness of a narrow grass hedge in reducing runoff nutrient transport from plots with a range of soil nutrient values. Composted beef cattle manure was applied at dry weights of 0, 68, 105, 142, and 178 Mg ha-1 to a silty clay loam soil and then incorporated by disking. Soil samples were collected 243 days later for analysis of water-soluble phosphorus (WSP), Bray and Kurtz No.1 phosphorus (Bray-1 P), NO3 …

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Biodegradable Fluorescent Polymers, Santosh Gautam Jul 2008

Biodegradable Fluorescent Polymers, Santosh Gautam

Bioengineering Theses - Archive

Most of the works done on fluorescent polymers are focused on their potential applications in lighting industries. Much less interest has been paid for their potential application in the field of biology and biomedical engineering. Although multiple biological uses of green fluorescent proteins (GFPs) have been addressed by different groups, their potential for biomedical applications is hampered by their tendency to photobleach rapidly and their short fluorescence lifetime. Quantum dots have emerged as a potential substitute for those applications, but their cytotoxicity and lack of biodegradability restrict their use in a biological system. An ideal fluorescent material that could be …

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Visible Versus Near-Infrared Light Penetration Depth Analysis In An Intralipid Suspension As It Relates To Clinical Hyperspectral Images, Tinsy John Perumanoor Jul 2008

Visible Versus Near-Infrared Light Penetration Depth Analysis In An Intralipid Suspension As It Relates To Clinical Hyperspectral Images, Tinsy John Perumanoor

Bioengineering Theses - Archive

We determine the penetration depth of near-infrared and visible light in a tissue phantom model using various image processing techniques and chemometrics and use these results to demonstrate the application of a multimodal hyperspectral imaging system for monitoring blood perfusion in amputation wounds. It is capable of performing a noninvasive, in vivo, quantitative analysis of human tissue in a clinical environment, in terms of the percent saturation of oxyhemoglobin. The instrument majorly consists of near-infrared and visible charge coupled devices (CCDs), lenses, liquid crystal tunable filters (LCTFs) for both the CCDs attached to their respective lenses, and a broad band …

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Nanoengineered Templates For Controlled Delivery Of Bioactive Compounds, Nalinkanth Ghone Veerabadran Jul 2008

Nanoengineered Templates For Controlled Delivery Of Bioactive Compounds, Nalinkanth Ghone Veerabadran

Doctoral Dissertations

The significance of any drugs, therapeutic proteins, or any bioactive compounds, is based not only on their effects on diseases but also on how specifically, how readily, how controllable and how prolonged their effects on the disease without having any side effects. Thus the techniques involved in the drug encapsulation and its controlled release for a longer duration of time form one of the important processes of drug reformulation. In recent years nanoparticles have created overwhelming attention for delivering drugs by nanoencapsulation. The smaller size of nanoparticles has longer circulation time and higher cellular uptake when compared with larger size …

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