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Teacher Education and Professional Development

2023

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Articles 31 - 60 of 127

Full-Text Articles in Science and Mathematics Education

Eipeck: Assessing Educators’ Pedagogical Content Knowledge For Engineering Integration In K-12, Pilar Pazos, Francisco Cima Cohuo, Jennifer Kidd, Kristie Gutierrez, Krishnanand Kaipa, Orlando Ayala Sep 2023

Eipeck: Assessing Educators’ Pedagogical Content Knowledge For Engineering Integration In K-12, Pilar Pazos, Francisco Cima Cohuo, Jennifer Kidd, Kristie Gutierrez, Krishnanand Kaipa, Orlando Ayala

Journal of Pre-College Engineering Education Research (J-PEER)

Global efforts are underway to include engineering in pre-college curricula. In the USA, this pursuit led to the inclusion of engineering content in the most recent version of the Next Generation Science Standards that guide K-12 science. As these standards become part of the K-12 curriculum, teachers face the challenge of gaining basic engineering literacy, while developing the associated inclusive pedagogies necessary to integrate engineering content into their classrooms. In this context, teacher preparation programs can benefit from easy-to-implement tools that measure preservice teachers’ readiness to integrate engineering content in their future classrooms. This work describes the development and validation …


Systems Thinking Applied To Higher Education Curricula Development, Reza Rahdar, Mark London, Yuetong Lin, Hong Jiang Sep 2023

Systems Thinking Applied To Higher Education Curricula Development, Reza Rahdar, Mark London, Yuetong Lin, Hong Jiang

Publications

Systems Thinking (ST) is a general and yet nebulous term that describes an approach to understanding and working with complexity in the real world. ST seeks to evaluate different behaviors of individual system elements when they operate in isolation as opposed to when they are integrated as part of a larger system and placed within a particular operating environment. The education environment consists of multiple systems with different digital content, learning goals/outcomes that serve different stakeholders including teachers, learners, and administrators. The inherent complexity and interaction among these various educational system elements and functions make this environment a worthy candidate …


Comparing Time Allocation For Teaching Science As Inquiry In Two Educator Preparation Science Methods Courses, Lori A. Dira Sep 2023

Comparing Time Allocation For Teaching Science As Inquiry In Two Educator Preparation Science Methods Courses, Lori A. Dira

Faculty Journal Articles

How much time an institution allocates to content can indicate its overall importance and intended value to the educator preparation program. For decades there have been calls to integrate more authentic science inquiry experiences into not only undergraduate elementary science courses, but into all elementary educator preparation courses. Many elementary educators do not receive training on effective methods for teaching science, they will not feel comfortable and will likely have low self-efficacy. This study investigated the amount of time allocated to teaching science as inquiry and the knowledge participants had prior to and after taking an elementary teaching science methods …


B/Lv Laboratory Accessibility Technology Adapted For Neurodiverse Chemistry Students, Christin B. Monroe Sep 2023

B/Lv Laboratory Accessibility Technology Adapted For Neurodiverse Chemistry Students, Christin B. Monroe

Journal of Science Education for Students with Disabilities

Text-to-speech technology is a common accommodation available for students with disabilities. Despite the ubiquitous nature of text-to-speech, this technology has not been explored in laboratory settings for neurodiverse college students. This study explores the adaptability of laboratory accessible text-to-speech technology (originally developed for blind/low vision (B/LV) students) for neurodiverse students. Students were asked to provide general feedback about the usability and effectiveness of the technology using Likert surveys. The students also answered open-ended questions about how the technology could be adapted to be more neurodiverse friendly. Overall, more than 50% of the students found the technology useful but had specific …


Examining The Change In Preservice Mathematics Teachers’ Conceptions And Effectiveness Of Social Justice Content, Gregory A. Downing, Brittney L. Black Aug 2023

Examining The Change In Preservice Mathematics Teachers’ Conceptions And Effectiveness Of Social Justice Content, Gregory A. Downing, Brittney L. Black

Journal of Research Initiatives

This study examined preservice teachers' perceptions of teaching mathematics using social justice topics to make mathematics accessible to all students. Situated at a large, public, predominantly White institution in the southeast United States, where preservice teachers are not required to take a course on teaching diverse populations, participants were asked to respond to questions surrounding their experience with a mathematical social justice activity adapted from Gutstein and Peterson (2005). Using a mixed methods approach in analyzing data from pre-and post-surveys, researchers could compare preservice mathematics teachers' initial views of teaching mathematics for social justice after participating in an intervention/activity on …


An Analysis Of Secondary Mathematics Teacher Learning In The Midwest Master Teacher Partnership, Jenny Lynn Sagrillo Aug 2023

An Analysis Of Secondary Mathematics Teacher Learning In The Midwest Master Teacher Partnership, Jenny Lynn Sagrillo

Theses and Dissertations

This case study investigates the professional learning and changes in teaching practices and leadership of four experienced, mid-career secondary mathematics teachers as a result of participation in the Midwest Master Teacher Partnership, a professional development partnership between a research university and a large, urban school district. The design of the professional development was based primarily on teacher action research; it placed the teacher at the center of the learning experiences, and included considerations of teachers’ existing knowledge, contexts, community, and assessment.The primary research question is, “How have teachers’ practices changed through their participation in a practice-based professional development project?” To …


Exploring Culturally Responsive Equitable Problem-Solving Pedagogy: Theorizing, Developing & Teaching, Tisha Newton Jones Aug 2023

Exploring Culturally Responsive Equitable Problem-Solving Pedagogy: Theorizing, Developing & Teaching, Tisha Newton Jones

Teaching & Learning Theses & Dissertations

Achievement gaps in mathematics between middle and high school Black students when compared to their white peers exist in part because of access, but also because Black learners’ brilliance is not recognized. Finding ways to help students, especially Black students, become successful mathematical problem solvers was a driving force behind this research. The purpose of this research is to explore ideas of how to improve Black students' opportunities to engage in effective mathematical problem solving to improve their mathematics understanding and achievement. This study introduces the Culturally Responsive Equitable Problem Solving (CREPS) pedagogy situated at the intersections of a conceptual …


Universal Design For Learning (Udl) In Inclusive Preschool Science Classrooms, Marla J. Lohmann, Katrina A. Hovey, Ariane N. Gauvreau Jul 2023

Universal Design For Learning (Udl) In Inclusive Preschool Science Classrooms, Marla J. Lohmann, Katrina A. Hovey, Ariane N. Gauvreau

Journal of Science Education for Students with Disabilities

Science instruction is a critical aspect of early learning. Teachers can support young children’s learning about scientific concepts through the use of the Universal Design for Learning (UDL) framework, which is a proactive approach to instructional planning that helps ensure success for all learners. This teaching techniques article offers preschool teachers practical solutions for implementing in the UDL framework for science instruction in their classrooms.


A Professional Development Program For Science Adjunct Faculty: The Mentoring-Learning Community (Mlc), Linda B. Purvis, Jason D. Lang, Julie A. Luft Jul 2023

A Professional Development Program For Science Adjunct Faculty: The Mentoring-Learning Community (Mlc), Linda B. Purvis, Jason D. Lang, Julie A. Luft

Georgia Journal of Science

Institutions of higher education have become increasingly dependent on adjunct faculty. These faculty members are often unfamiliar with current teaching strategies emphasizing an active learning approach. To support science adjunct faculty in learning about active learning, a professional development program was designed and implemented by the authors of this study, the Mentoring-Learning Community. The Mentoring-Learning Community program design was informed by literature regarding the use of professional development programs that focused on adjunct faculty. To determine the impact of this program, participants in the Mentoring-Learning Community were observed and interviewed over one semester. Mentoring-Learning Community participants transformed through all three …


Mathematical Identities And Tracking: An Exploration Of Efficacy In Children And Women, Emma Hagan Jul 2023

Mathematical Identities And Tracking: An Exploration Of Efficacy In Children And Women, Emma Hagan

Education | Master's Theses

This study seeks to understand the impact of elementary school mathematical identities and mathematics tracking on the identities of women and girls. “Tracking” is an institutionalized education method developed in the 1960s and 1970s in which schools sort their students into smaller class-sized groups based on their observed achievement (Domina et al., 2016). Too often, when students test onto the lower track, they are confronted with a sense of futility and a lack of self-efficacy (Domina, Hanselman, Hwang & McEachin, 2016; Houtte & Stevens, 2015). Further, in STEM disciplines, students who identify as female report lower self-efficacy rates than those …


In Their Words: Prospective Teachers' Experiences As A Context For Investigating Their Views Of Authority In A Mathematics Classroom, Brenda Lynn Rosencrans Jul 2023

In Their Words: Prospective Teachers' Experiences As A Context For Investigating Their Views Of Authority In A Mathematics Classroom, Brenda Lynn Rosencrans

Dissertations and Theses

Mathematics teacher educators enact inquiry-based preparatory courses with the underlying expectation that their students (prospective teachers) will take ownership (authority) of their mathematical learning through sharing their ideas and collaboratively discussing the reasonableness of their shared ideas. Yet, prospective teacher' expectations are often not yet in alignment with those of mathematics teacher educators, instead they enter these courses expecting their instructors to provide clear examples and directions for how to solve mathematics problems. This project investigates this dynamic through an authority lens, seeking to understand and characterize different views of authority prospective teachers hold and the impact these views have …


The Challenge: Magazine For The Center For Gifted Studies (No. 54, Summer 2023), Elizabeth Joyce Editor, Western Kentucky University Jul 2023

The Challenge: Magazine For The Center For Gifted Studies (No. 54, Summer 2023), Elizabeth Joyce Editor, Western Kentucky University

Gifted Studies Publications

Magazine created by and about the WKU Center for Gifted Studies.


Teaching Mathematics To All Learners By Tapping Into Indigenous Legends: A Pathway Towards Inclusive Education, Nahid Golafshani Jul 2023

Teaching Mathematics To All Learners By Tapping Into Indigenous Legends: A Pathway Towards Inclusive Education, Nahid Golafshani

Journal of Global Education and Research

This study explored the use of Indigenous storytelling in the planning and teaching of mathematical content. In collaboration with Indigenous and non-Indigenous educators, a culturally inclusive mathematical lesson was developed, implemented, and reviewed in an elementary school in Northern Ontario. This study used a culturally authentic approach to address the current educational issue of diversity within the Ontario curriculum and education system. The results of this study suggested that utilizing Indigenous storytelling for teaching mathematical curricular expectations could benefit both Indigenous and non-Indigenous students. Storytelling can allow students to relate abstract mathematical concepts to their own lived experiences, to be …


Meet Me In The Middle: A Scoping Review On Understanding Adolescent Needs In Climate Communication, Gwendolyn Monica Hoff Anderson Jul 2023

Meet Me In The Middle: A Scoping Review On Understanding Adolescent Needs In Climate Communication, Gwendolyn Monica Hoff Anderson

Master's Projects and Capstones

The greatest effects of climate change are likely to be felt by youth. Young people are disproportionately affected by climate change due to their critical developmental stage and lack of power, and they experience both higher severity and prevalence of mental health issues related to climate change. Strong emotions have long been recognized as potential catalysts for action, or they may lead to paralyzing feelings of being overwhelmed. Climate communication is a critical tool to spark climate concern and encourage action. Activism, in turn, may help youth manage their anxiety about climate change. This scoping review examines emerging evidence on …


Evolution Of Novice Teachers’ Instructional Visions To Teach Elementary Mathematics: A Longitudinal Collective Case Study, Amber Nicole Brown Jun 2023

Evolution Of Novice Teachers’ Instructional Visions To Teach Elementary Mathematics: A Longitudinal Collective Case Study, Amber Nicole Brown

USF Tampa Graduate Theses and Dissertations

This longitudinal collective case study is about the transformational experiences of three novice elementary teachers, Tammy, Katie, and Michelle, as they moved from an elementary teacher preparation program, at a large research university in the southeast United States, through their first two years of teaching in different elementary school contexts. Situated within literature pertaining to instructional vision and visions of high-quality mathematics instruction (VHQMI), these cases were used to explore the teachers’ perceptions of their visions of high-quality mathematics instruction and how these perceptions evolve over time. The study design prioritizes novice teacher voices as predominant data sources to elevate …


The Developmental Experiences Of Exemplary Statistics Teachers, Douglas Whitaker Jun 2023

The Developmental Experiences Of Exemplary Statistics Teachers, Douglas Whitaker

Northwest Journal of Teacher Education

There has been a trend of increased statistical expectations for students and calls for increased statistical preparation for their teachers in recent years, but preparation has not yet reached recommended levels. A similar preparation gap existed at the inception of the Advanced Placement Statistics program, and this study examines a group of statistics teachers identified as exemplary by experts in the field to determine what challenges they faced and how they overcame them. Semi-structured interviews using a Communities of Practice framework (Wenger, 1998) were conducted. The challenges and responses to those challenges are identified, and these have implications for supporting …


Examination Of Training On Pre-Service Science Teachers’ Views On Socio-Scientific Issues And Nature Of Science, Aylin Çam Jun 2023

Examination Of Training On Pre-Service Science Teachers’ Views On Socio-Scientific Issues And Nature Of Science, Aylin Çam

Journal of Educational Research and Practice

Science continuously interacts with the social environment. Science develops with social needs, and society develops and changes with scientific advances. These changes and developments may cause dilemmas in society. Thus, the purpose of this study is to investigate the improvements among pre-service science teachers in terms of socio-scientific issues and nature of science after explicit theoretical and practical training. The participants in this case study were 16 voluntary pre-service science teachers. In-depth views of the pre-service science teachers on nature of science and socio-scientific issues were examined with open-ended questions and reflective diaries. After the training, the understanding of the …


Enacting Inclusive Mathematics Teaching And Learning Using Biography Driven Instruction, Jessie C. Store May 2023

Enacting Inclusive Mathematics Teaching And Learning Using Biography Driven Instruction, Jessie C. Store

Journal of Educational Research and Practice

As schools become increasingly diverse, there is an increasing need for examples of classroom practices that create inclusive teaching and learning environments. Many research studies found that gaining knowledge of student home life and using it to bridge learning and home supports access and equity. Many scholars have called for exemplars of activities that connect students’ in-school and out-of-school cultural activities. This paper provides an example that may be used in teacher education and K–12 classrooms to bridge out-of-school and in-school activities. In this paper, we discuss the enactment of biography-driven instruction, specifically how cultural biographies can be used to …


Overview Of The Proceedings Of The 2022 Inclusion In Science, Learning A New Direction, Conference On Disability (Island), Cary A. Supalo, Jasodhara Bhattacharya, Daniel Steinberg May 2023

Overview Of The Proceedings Of The 2022 Inclusion In Science, Learning A New Direction, Conference On Disability (Island), Cary A. Supalo, Jasodhara Bhattacharya, Daniel Steinberg

Journal of Science Education for Students with Disabilities

The 13th annual Inclusion in Science, Learning a New Direction, Conference on Disability was hosted by the Princeton Center for Complex Materials (PCCM), a National Science Foundation funded Materials Research Science and Engineering Center (MRSEC), and Princeton University on September 16-17, 2022 at Bowen Hall. This annual conference included presentations that featured innovative research done by science educators in formal and informal education contexts, ranging from pre-K-12 to higher education, and science education researchers, access technology developers, and others interested in the full inclusion of persons with disabilities into the Science, Technology, Engineering, and Mathematics (STEM) workforce. The 2022 ISLAND …


From The Editors..., Todd Pagano May 2023

From The Editors..., Todd Pagano

Journal of Science Education for Students with Disabilities

No abstract provided.


Democratic Disagreements. A Book Review Of Lived Democracy In Education. Young Citizens’ Democratic Lives In Kindergarten, School And Higher Education, Sonja Helkala, Julia Jaakkola, Tuukka Tomperi May 2023

Democratic Disagreements. A Book Review Of Lived Democracy In Education. Young Citizens’ Democratic Lives In Kindergarten, School And Higher Education, Sonja Helkala, Julia Jaakkola, Tuukka Tomperi

Democracy and Education

As the title Lived Democracy in Education suggests, the predominantly Norwegian writers of the book share a deep and robust vision of democracy. Drawing on deliberative democratic theory and many other theoretical perspectives, the authors blend theory, practice, and empirical case studies to illuminate these modes of “lived democracy” in educational contexts. In particular, the book’s chapters examine different communicative interactions between children and young people, presenting these as examples of learning to live with controversies in communities of disagreement. The book contains valuable perspectives on democratic discussion in education. As several authors are experts in mathematics and science education, …


Magnetic Resonance Image-Based Estimates Of Hepatic Blood Flow In Children With And Without Obesity; Implications For Physiologically-Based Pharmacokinetic Models, Yoon Cho, Sherwin S. Chan, Chance S. Friesen, Valentina Shakhnovich May 2023

Magnetic Resonance Image-Based Estimates Of Hepatic Blood Flow In Children With And Without Obesity; Implications For Physiologically-Based Pharmacokinetic Models, Yoon Cho, Sherwin S. Chan, Chance S. Friesen, Valentina Shakhnovich

Research Days

Background: Physiologically based pharmacokinetic models for simulating drug pharmacokinetics are useful to guide drug dosing for pediatric patients. Hepatic blood flow could be a useful variable to use in these models.

Objectives/Goal: In this study, we explored 2-D phase contrast non-invasive magnetic resonance imaging (MRI) to measure hepatic blood flow in children with and without obesity.

Methods/Design: In this IRB-approved study, we imaged pediatric patients with abdominal MRI with 2D phase contrast imaging of the descending aorta (AO) at the diaphragm, the inferior vena cava (IVC) at the right atrium, and inferior to hepatic drainage above the renal vein confluence …


Persistent Pediatric Breast Abscesses Following Initial Treatment At Tertiary And Community Centers, Derek Marlor, Kayla Briggs-Groves, Shai Stewart Md, Nelimar Cruz-Centeno, Charlene Dekonenko, Jason D. Fraser May 2023

Persistent Pediatric Breast Abscesses Following Initial Treatment At Tertiary And Community Centers, Derek Marlor, Kayla Briggs-Groves, Shai Stewart Md, Nelimar Cruz-Centeno, Charlene Dekonenko, Jason D. Fraser

Research Days

Introduction: Little data exist on the management of pediatric breast abscesses that fail initial treatment. Therefore, this study aimed to evaluate and report outcomes in these patients.

Methods: All patients <18-years-old treated for a breast abscess between January 2008 and December 2018 were included. Patients were divided into 2 groups: initial treatment at our institution (Group 1) and initial treatment at referring centers (Group 2). The primary outcome was disease persistence following treatment at our institution. Secondary outcomes included treatment modalities and patient characteristics.

Results: In total, 145 patients were identified: 111 in Group 1 and 34 in Group 2. Antibiotics alone were the initial treatment in 52.3% (n=58) of Group 1 patients and 64.7% (n=22) of Group 2 patients. Invasive treatment was more common in Group 1 (45.9% vs 5.8%; p<0.00001). Patients with persistent disease in Group 1 were treated with aspiration (n=7, 50%), I&D (n=5, 35.7%), antibiotics (n=1, 7.14%), and manual expression (n=1, 7.14%.), while Group 2 patients were treated with antibiotics (50%, n=17), aspiration (26.47%, n=9), I&D (17.65%, n=6), and manual expression (5.88%, n=2). Group 2 patients with persistent disease were more likely to be treated with antibiotics or a change in antibiotics (50% vs 7.14%; p=0.005). Following treatment at our institution, the rate of persistent disease was similar between groups (12.6% vs 11.8%).

Conclusions: Persistent breast abscesses may be treated with antibiotics in appropriate cases. Damage to the developing breast bud should be minimized. Disease …


How Students Investigate: Understanding Students’ Use Of Scientific Schemas In Open-Ended Labs, J. Alexander Wall May 2023

How Students Investigate: Understanding Students’ Use Of Scientific Schemas In Open-Ended Labs, J. Alexander Wall

Masters of Education in Teaching and Learning

Schema provides a theoretical framework for understanding the nature of science, inquiry, and open-ended labs. These topics have been emphasized in the state standards, especially in high school sciences. In this study the researcher took field notes, collected lab write ups, and conducted focus group interviews to understand students’ use of schema related to open-ended labs. These data were analyzed with the constant comparative method to generate themes. The author describes the major findings with parallel narratives, one focused on a student’s confusion and the other focused on a student’s understanding. The author concludes by advocating for science teachers to …


Growth Mindset Intervention And Its Impact On Productive Struggle In The Eighth-Grade Mathematics Classroom, Jordy Wilson May 2023

Growth Mindset Intervention And Its Impact On Productive Struggle In The Eighth-Grade Mathematics Classroom, Jordy Wilson

Doctor of Education in Secondary and Middle Grades Education Dissertations

This study aims to seek means to increase student productive struggle while adhering to the strenuous performance demands by our school systems. This study examines connections between growth mindset interventions, attitude towards struggle, and productive struggle in the mathematics classroom. Growth mindset interventions have been shown to change mindsets and to help students become more willing to engage in challenging problems and deal with difficult situations and struggle. Productive struggle is the engagement with difficult problems with the understanding that breakthroughs occur from confusion and struggle and has been linked with students’ conceptual understanding in the mathematics classroom. It has …


Anxious Times Call For Additional Goal Setting Measures: A Look At How Math Anxiety Is Impacted By Setting Goals In An Algebra I Class, Raegan Palacio May 2023

Anxious Times Call For Additional Goal Setting Measures: A Look At How Math Anxiety Is Impacted By Setting Goals In An Algebra I Class, Raegan Palacio

Masters of Education in Teaching and Learning

This study examined the impact that goal setting would have on Algebra I students’ math anxiety by comparing a control group to a treatment group. Students took the Math Anxiety Survey (Godbey, 1997) as a pre- and post-assessment. The researcher taught a goal setting mini lesson at the beginning of the data collection period to the treatment group (Class B), and students set weekly goals for themselves in relation to Algebra I class. Students in Class B journaled weekly, and some students participated in focus groups depending on their levels of math anxiety. The qualitative data was analyzed using the …


Respiratory Pathogen Panel Use In Hospitalized Infants <2 Months Of Age And Impact On Patient Management., Edward Lyon May 2023

Respiratory Pathogen Panel Use In Hospitalized Infants <2 Months Of Age And Impact On Patient Management., Edward Lyon

Research Days

Background: Respiratory pathogen panels (RPP) are multiplex PCR platforms able to simultaneously detect several respiratory viruses. RPP utilization is not well described in infants < 2 months of age, who frequently require hospitalization for management of acute respiratory illness (ARI) and/or fever. Detection of a viral pathogen in this age group could impact the clinician’s decision to perform additional evaluation and administer antimicrobials.

Objectives/Goal: We sought to understand predictive features and clinical management impact of RPP use in infants < 2 months of age.

Methods/Design: Between October 2017 to September 2021, participants, aged < 18 years, hospitalized with an acute respiratory infection (ARI) were enrolled in Kansas City’s New Vaccine Surveillance Network (NVSN). Eligible patients were residents of Jackson County, had symptoms consistent with ARI (e.g., cough, fever, nasal congestion) lasting < 14 days, and enrolled within 48 hours of admission. For this study, only participants < 2 months of age were included. All participants had a research RPP, but results were not available to the clinician. Per provider discretion, some infants also received a clinical RPP (cRPP). Demographic characteristics, laboratory evaluations, and antimicrobial management were compared between infants with and without a cRPP.

Results: Of the 139 participants < 2 months of age, 57 (41%) had a cRPP (table 1). A cRPP was more frequently obtained in infants < 1 month of age (n=34 [47%]) compared with infants 1-2 months of age (n=23 [35%]; p=0.17). 35 (61%) participants with a cRPP had a parental report of fever while 41 (50%) of those without a cRPP had one reported. Only 20 (35.1%) of White, non-hispanic participants had a cRPP compared to 42 (51.2%) p=0.082 who did not have a cRPP. Participants who had blood or CSF culture collected were more likely to have a cRPP obtained, 47 (82.5%) p=

Conclusions: Overall, < 50% of infants < 2 months of age hospitalized with ARI received cRPP testing. Obtaining a blood or CSF culture was associated with increased cRPP usage. The length of stay was not different between the two groups. 35 viral infections went undetected in participants without a cRPP even with accounting for positive rapid NAAT testing, further investigation is needed to understand how this may influence clinical care.


Association Between Remote Monitoring And Interstage Morbidity And Mortality In Single Ventricle Patients Across Socioeconomic Groups, Bianca Cherestal May 2023

Association Between Remote Monitoring And Interstage Morbidity And Mortality In Single Ventricle Patients Across Socioeconomic Groups, Bianca Cherestal

Research Days

Background: Despite improvements in outcomes over time, morbidity and mortality for infants with single ventricle (SV) heart disease remains high. Among other risk factors for mortality, infants of low socioeconomic status (SES) are known to be particularly vulnerable following stage 1 palliation.

Objectives/Goal: We sought to determine whether use of a novel remote monitoring program, CHAMP (Cardiac High Acuity Monitoring Program), mitigates differences in outcomes by SES for infants with SV during the interstage period.

Methods/Design: Using the CHAMP database, we identified 610 infants across 11 institutions enrolled in the program between 2014–2021. All enrolled patients’ families were provided with …


Drug Metabolizing Enzymes And Transporters May Help Determineeffective Budesonide Dosing In Eoe, Laurie Mccann, Lisa Harvey, Norah Almahbub, Wendy Y. Wang, Erin C. Boone, Janelle R. Noel-Macdonnell Phd, Rachel Chevalier May 2023

Drug Metabolizing Enzymes And Transporters May Help Determineeffective Budesonide Dosing In Eoe, Laurie Mccann, Lisa Harvey, Norah Almahbub, Wendy Y. Wang, Erin C. Boone, Janelle R. Noel-Macdonnell Phd, Rachel Chevalier

Research Days

Background: Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder diagnosed in children with painful or difficult swallowing, vomiting, or poor weight gain. Current treatment models adopt a trial-and-error approach in regard EoE treatment, including restrictive elimination diets, proton pump inhibitors, and topical budesonide. This approach can delay effective treatment which increases risk of disease progression and increases medical costs to families for frequent clinic visits and endoscopy.

Objectives/Goal: The objective of this study is to determine the CYP3A5 genotype and expression of patients with eosinophilic esophagitis to discover which patients will respond to standard dosing of topical budesonide treatment (1, …


Genes Predictive Of Aggressive Infant Acute Lymphoblastic Leukemia, Meghana Bhumireddy May 2023

Genes Predictive Of Aggressive Infant Acute Lymphoblastic Leukemia, Meghana Bhumireddy

Research Days

Background: Acute Lymphoblastic Leukemia (ALL) is a rapidly progressive cancer in which the bone marrow makes too many immature leukocytes that divide uncontrollably. KMT2A, or MLL, is a methyltransferase found in many types of leukemia, whose rearrangement (KMT2A-r) is present in approximately 2/3 of infants with ALL. KMT2A-r is associated with a very poor prognosis: roughly ⅔ of patients relapse within 1 year of diagnosis, and the relapsed KMT2A-r ALL is resistant to treatment (having nearly 100% morality). We explored gene expression in patient samples from three groups at diagnosis: KMT2A-r patients who relapsed, KMT2A-r patients who did not relapse, …