Digital Commons Network^™

Evaluating The Reliability And Accuracy Of Alchemical Binding Free Energy Methods And Calculations, Fnu Sheenam

Dissertations, Theses, and Capstone Projects

Molecular recognition plays a crucial role in various biological processes, such as enzymatic reactions, signal transduction, and genetic information processing. Investigating how proteins selectively bind to their partners is an active research area, but there is a lack of experimental details on protein structures and interactions in molecular complexes. Computational techniques based on macromolecular structures offer a way to predict protein-ligand interactions and explore their recognition mechanisms. Estimating binding affinities, particularly through alchemical binding free energy calculations, has become valuable in supporting drug discovery. This work introduces new methodologies, utilizing the Alchemical Transfer Method, to address issues like poor convergence …

In-Work Recovery Among Hybrid Employees: Examining The Relationships Between Stressors, Recovery Experiences, And Strains, Stefanie Larsen

Dissertations, Theses, and Capstone Projects

There has been a drastic increase in the number of hybrid employees (i.e., employees who work remotely for part of a workweek) since the COVID-19 pandemic. While previous research has highlighted some of the benefits and costs of remote work, research on hybrid work is still in its early stages. One area that remains unclear is how hybrid work relates to stressor experiences and in-work recovery from work. The present study examined how levels of specific stressors (i.e., workload, availability pressure) vary depending on whether employees work remotely or in the office, and how the variations of these stressors across …

Migrant Children And Legislation: Integrating Knowledge About Trauma Into Policy, Yolennys E. Albornoz

Dissertations, Theses, and Capstone Projects

This study seeks to integrate some knowledge about trauma into migration policies in the U.S. regarding children. Migration is not a novel concept; it is a dynamic phenomenon that experiences continuous changes and constantly increases in numbers. Globally, the United States has been the primary destination for foreign migrants for a long time, and most of them are Latinos who cross the U.S. and Mexico border. Here, I explore how children face trauma in their home country, which forces them to migrate. Also, while they migrate and after they have migrated, exposing the three stages of trauma for migrant children. …

Protein-Protein Interactions In Cell Cycle Proteins: An In Silico Investigation Of Two Important Players, Andriele Eichner

Dissertations, Theses, and Capstone Projects

The examination of the cell cycle carries significant implications for the biology, health, and overall existence of all living things. These implications span from the development and growth of these organisms to the aging process and cancer, as well as the potential of stem cell therapies to repair diseases and injuries. Numerous proteins of the cell cycle are essential for cellular division and proliferation and are widely conserved over the course of evolution. In this work, we aimed to investigate the molecular processes of protein-protein interactions in cell cycle proteins, centering on two key players: Cdc6 in budding yeast and …

Knowing The Patient As A Person: Social Media Listening And Gadamerian Analysis Of Nurses’ Expressions Shared During The Covid-19 Global Health Pandemic, Janusz A. Kaleta

Dissertations, Theses, and Capstone Projects

Background: COVID-19 has dramatically changed human-to-human interactions from in-person to the nonhuman domain of virtual space. In January 2021, every 28 seconds one person died of COVID-19 in the United States. An average of 3,100 Americans died each day during the deadliest month of the pandemic. As of January 2023, the number of COVID-19 deaths in the USA surpassed 1.000.000 people. In hospitals, human-to-human interactions were often limited to seeing one’s eyes behind the face shields, and respirator masks, and hearing a muffled voice, or sounds of the ventilators. In New York State 452 nurses died during the pandemic.

Research …

No Ela Without Ella: Understanding The Naming And Crafting Of Gendered Subjectivities In Puerto Rico, Carmín Quijano Seda

Dissertations, Theses, and Capstone Projects

At the beginning of the 20th century, the official metadiscourses about gendered job titles sedimented the idea that names or indexes pointing to women should be interpreted as unskilled, cheap, or even free labor in Puerto Rico (Azize, 1985; Muñiz Mas, 1998; Baerga-Santini, 1999). For this reason, Puerto Rican women organized and fought for equality in work settings. Furthermore, they became more active in politics and the government. Nevertheless, the Estado Libre Asociado (ELA) and local media discourses and interpretations about women’s labor discouraged them from participating in more senior positions (Acevedo Gaud, 2012).

However, this interpretation seemed to have …

Deep Learning-Based Human Action Understanding In Videos, Elahe Vahdani

Dissertations, Theses, and Capstone Projects

The understanding of human actions in videos holds immense potential for technological advancement and societal betterment. This thesis explores fundamental aspects of this field, including action recognition in trimmed clips and action localization in untrimmed videos. Trimmed videos contain only one action instance, with moments before or after the action excluded from the video. However, the majority of videos captured in unconstrained environments, often referred to as untrimmed videos, are naturally unsegmented. Untrimmed videos are typically lengthy and may encompass multiple action instances, along with the moments preceding or following each action, as well as transitions between actions. In the …

Rational Design Of Peptide-Based Materials Informed By Multiscale Molecular Dynamics Simulations, Dhwanit Rahul Dave

Dissertations, Theses, and Capstone Projects

The challenge of establishing a sustainable and circular economy for materials in medicine and technology necessitates bioinspired design. Nature's intricate machinery, forged through evolution, relies on a finite set of biomolecular building blocks with through-bond and through-space interactions. Repurposing these molecular building blocks requires a seamless integration of computational modeling, design, and experimental validation. The tools and concepts developed in this thesis pioneer new directions in peptide-materials design, grounded in fundamental principles of physical chemistry. We present a synergistic approach that integrates experimental designs and computational methods, specifically molecular dynamics simulations, to gain in-depth molecular insights crucial for advancing the …

Algorithmic Love: Twenty-First Century Organizations Of The Romantic, Sandra Moyano Ariza

Dissertations, Theses, and Capstone Projects

This dissertation investigates the highly computed and accelerated experiences of digital love as well as their cultural and artistic representations in order to shed light on the human and more-than-human entanglements producing the algorithmic love experience. The recent turn to love in critical theory and cultural studies examines how love circulates in neoliberal societies and in the subjective processes of the users, foregrounding the control of populations and the very much lamented “end of love” (Illouz 2019). My study of love supplements the neoliberalist critique of algorithmic love with a posthuman and media theory approach that attends to the material …

Border Confinement And Assistance Markets In Tijuana: Mexican Deportees’ Experiences Of Labor And Violence Between Mexico And The United States, Christian Pacheco-Gómez

Dissertations, Theses, and Capstone Projects

This dissertation is an ethnography of deportation and describes how Tijuana’s (Baja California, Mexico) border redevelopment and spatial redesign has impacted in Mexican job seekers’ mobilities, incorporation, and stigmatization after experiencing forced removals from the United States. The dissertation explores three processes interwoven in the deportees’ class experiences of migration and deportation.

First, I trace Mexican job seekers’ trajectories of labor and migratory movement before, during, and after deportation as well as their incorporation stories in Tijuana. Second, I reconstruct the political economy of reception immigrant subjects encounter after being deported from the United States and subjected by Tijuana’s border …

Critical-Race Elementary Schooling: Critical-Race Teacher Change Agents Are Challenging Whiteness In Elementary Schools, David R. Rosas

Dissertations, Theses, and Capstone Projects

Children in elementary schools think, talk, and reason in big ways that reflect how they live and experience race, racism, and racialization. Some elementary school teachers -- or critical-race teacher change agents -- intentionally include this work in their classrooms. My aim is to find out what motivates critical-race teacher change agents to challenge Whiteness in their classrooms and understand what they say they do to challenge Whiteness with young children.

An emphasis on racial-justice work in elementary schools has often been overlooked by teacher education and has been further pushed back by the recent backlash on critical race theory …

Racial Discrimination And Interpersonal Violence In Asian American Adolescents During The Covid-19 Pandemic, Shannon P Guillot-Wright

Faculty, Staff and Student Publications

PURPOSE: Racial discrimination targeting Asians in the United States has increased sharply since the COVID-19 pandemic. Despite a well-established link with mental/physical health outcomes, little is known about how racial discrimination relates to interpersonal violence, particularly in adolescents. To address this gap in knowledge, we examined cross-sectional and longitudinal (1-year follow-up) associations between racial discrimination and interpersonal violence perpetration and victimization in Asian American adolescents in a large US city.

METHODS: Data from Waves 3 (2020) and 4 (2021) of a randomized clinical trial of a school-based violence prevention program were examined. We limited our sample to participants who identified …

Risk Factors For Post-Discharge Adverse Outcomes Following Hospitalization Among Older Adults Diagnosed With Elder Mistreatment, Yong-Fang Kuo

Faculty, Staff and Student Publications

Using 100% Medicare data files, this study explored whether primary elder mistreatment (EM) diagnosis, EM type, and facility type were associated with 3-year mortality and 1-year unplanned hospital readmission among older patients diagnosed with EM with hospital discharge from 10/01/2015 through 12/31/2018 (n = 11,023). We also examined outcome differences between older patients diagnosed with EM and matched non-EM patient controls. Neglect by others was the most common EM diagnosis. Three-year mortality was 56.7% and one-year readmission rate was 53.8%. Compared to matched non-EM patient controls, older EM patients were at an increased risk of mortality and readmission. Among …

Safety And Academic Outcomes Of College Campus-Based Advocacy Services, Leila Wood

Faculty, Staff and Student Publications

Intimate partner violence (IPV), sexual assault, and stalking are consequential public health and safety issues with wide reaching impacts on emerging adults, including those on college campuses in the United States. In response to high rates of violence among college student populations, universities are developing campus-based advocacy (CBA) programs, which aim to support survivors of interpersonal violence through supportive connections, resource acquisition, and safety planning. However, little data exists related to their impact on key student-survivor outcomes. Thus, this study aims to understand (a) the approach CBA programs use to address safety and academic concerns of student-survivors, and (b) the …

Frenetic Journey Toward Muddledness: An Experimental Short Film, Fernando Vieira

Dissertations, Theses, and Capstone Projects

As an artist and Film Studies student, I saw the capstone option as an opportunity to consolidate academia with the art of filmmaking into one project. This became Frenetic Journey Toward Muddledness, an experimental short film written, directed, and edited by me. It is a film influenced by early avant-garde cinema, German expressionism, and film noir. Composed of pieces of unrelated footage and featuring an ambiguous, non-linear, and mostly silent narrative, the editing of the film prompted me to ask myself questions about its genre. Its hybridity made it possible to position the film within different categories, but there …

Dancing In The Heart Of The Empire, Talisa Feliciano

Dissertations, Theses, and Capstone Projects

Dancing in the Heart of the Empire is an urban ethnography of public transit space in New York City. The work is based on five years of research on the trains of the Metropolitan Transit Authority’s (MTA) subway system. This work primarily focuses on Black and brown youth dancers who perform on the subways. Combining participant observation, archival research, digital social media research, and interviews, the dissertation identifies dancing as a form of resistance to the racialized structure of the train space and New York City. Public transportation is the heartbeat of the city. It is a contested site of …

Exploring Cross-Linguistic Speech Perception In Hindi, English, And Romance-Language Through Temporal Dynamics Of Neural Activity, Yuga Kothari

Dissertations, Theses, and Capstone Projects

This study examines the effect of linguistic experience on the neural processing of Voice Onset Time (VOT) in Hindi and Romance language (Spanish and Portuguese) individuals who are bilingual in English and monolingual English speakers using the event-related potential (ERP) Mismatch Negativity (MMN) response. VOT is a linguistic property that measures the time elapsed between the release of a stop consonant and the beginning of voicing, that is, vocal fold vibration of a following vowel. In a double-oddball paradigm, participants’ (n = 41) ERP were recorded while listening to speech sounds differing in VOT. The bilabial short lag stop [p] …

Digital Rhetoric Of The Invisible: Bisexual Literacy Practices On Tiktok, 2020–2021, Olivia Wood

Dissertations, Theses, and Capstone Projects

This dissertation uses auto- and digital-ethnographic methods to analyze the literacy practices of bisexual TikTok users primarily during the first year of the Covid-19 pandemic in the United States, during which time TikTok exploded in popularity among U.S. social media users, especially among young adults. It is also an exercise in neuroqueer composing, diverging at times from the norms of academic writing and the dissertation genre to perform and intentionally draw attention to neuroqueer styles of thinking and communication. I argue that bisexual invisibility and contemporary bi+ rhetorical activity must be understood within the context of LGBTQ+ political history, particularly …

Clustering Of Patients With Heart Disease, Mukadder Cinar

Dissertations, Theses, and Capstone Projects

Heart disease, a leading cause of mortality worldwide, presents complex challenges in public health due to its varied manifestations. Accurate diagnosis and patient stratification are essential for effective management and improved outcomes. In response, this study employed machine learning techniques to analyze heart disease data obtained from UCI Machine Learning Repository, aiming to enhance patient care through advanced data analysis.

The study began with the application of K-Nearest Neighbors (KNN) classification, which categorized patients into 'Disease' and 'No Disease' groups. This preliminary step provided initial insights into the structure of the dataset. Subsequently, K-means clustering was applied in two rounds, …

Culturally And Socially Responsive Teacher Professional Learning At The American Museum Of Natural History, Jessica Correa

Dissertations, Theses, and Capstone Projects

This capstone project consists of a series of professional learning sessions to support teachers in their implementation of Culturally Responsive-Sustaining Education (CR-SE) using the American Museum of Natural History (AMNH) as a resource and case study. Through the lens of Historically Responsive Literacy, the series also seeks to reestablish social science as a critical element of natural history for teachers. This series can help teachers see the museum as not only a place to explore life and physical science, but also a place to explore identity, social/emotional development, cultural studies and American History. The project includes resources and directions for …

Tarot Fabula: Radical Digital Cards, Shuffled Narrative Structures, And Playing The Future In An Era Of Algorithms, Rachel M.L. Dixon

Dissertations, Theses, and Capstone Projects

Since their earliest recorded use in the 1400s, tarot cards figure as objects for game play, artistic creativity, spiritual divination, and self-discovery. Tarot Fabula (https://tarot-fabula.com) introduces a ludic, interactive website interface that challenges 20th century tarot reading practices as linear narratives. Statistically random reshufflings of tarot decks from archival collections prompt the reader to become a narrative co-creator, drawing them into conversation with traditional reading and interpretive practices as they remix narrative elements portrayed on the cards. Tarot Fabula’s shuffling and reshuffling of cards as historical objects merges contemporary computational methods for generating random results with an interrogation of …

Neurochemical Signaling Of Reward-Based Learning In Ventral Tegmental Area Dopamine Neurons, Kyla F. Wholley

Dissertations, Theses, and Capstone Projects

Ventral tegmental area (VTA) dopamine neurons signal and participate in reward-related learning. Specifically, dopamine is postulated to encode reward-related environmental stimuli to compute reward prediction errors (RPEs). It is through the computation and maintenance of RPEs that learning occurs. However, little is known about the neural mechanisms that underlie how dopamine neurons compute RPEs and facilitate reward-related learning. The present study utilized fiber photometry in conjunction with a Pavlovian reward-based task to identify how GABA inputs to VTA dopamine neurons contribute to the computation of RPEs and reward-based behavior. Activity of GABA inputs to VTA dopamine neurons increased for reward-predicting …

Synthesis And Characterization Of Donor-Acceptor Fluorescent Conjugated Polymers By Acyclic Diene Metathesis (Admet) And Suzuki Polycondensation (Spc), Hamid Ardolic Jr.

Dissertations, Theses, and Capstone Projects

Conjugated polymers are useful in a wide variety of applications including production of Light Emitting Diodes (LEDs), Field Effect Transistors (FETs) and organic photovoltaics. Our work in the lab focuses on the development of materials for use in Polymer Solar Cells (PSCs) using various electron donating and electron accepting units to individually tune the Highest Occupied Molecular Orbital (HOMO) and Lowest Unoccupied Molecular Orbital (LUMO) respectively and produce a small but controlled band gap. This is accomplished through the synthesis of several precursors and their subsequent polymerization using Acyclic Diene Metathesis (ADMET) and Suzuki Polycondensation (SPC). Moderately strong electron donors, …

Examining The Health Risks Of Particulate Matter 2.5 In New York City: How It Affects Marginalized Groups And The Steps Needed To Reduce Air Pollution, Freddy Castro

Dissertations, Theses, and Capstone Projects

The following examines the impact of particulate matter 2.5 (PM2.5) on public health, focusing on its sources and effects on vulnerable populations in New York City. PM2.5 is a particle that is 2.5 micrometers or less in diameter and, because of its size, can enter the bloodstream affecting the respiratory and cardiovascular systems and further complicating the health of the immunocompromised. Recent studies have shown that PM2.5 can come from various sources, including transportation and industrial emissions, as well as indoor sources like cigarettes and gas-operated stoves. Despite reduced levels of PM2.5 due to recent policy changes and initiatives taken …

Making Sense Of Making Parole In New York, Alexandra Mcglinchy

Dissertations, Theses, and Capstone Projects

For many individuals incarcerated in New York, the initial step toward freedom begins with an interview with the Board of Parole. This process, however, is frequently a complex and challenging one, characterized by repeated denials and extended incarcerations. The disparity in outcomes – where one individual may receive over 20 denials and another is granted parole on their first attempt – highlights the ambiguity and inconsistency in the parole decision-making process. This project aims to clarify the factors that influence parole decisions by concentrating on measurable variables. These include age, race, duration of sentence served, proportion of sentence served, type …

The True And Only Technic: Technological Ubiquity And Its Critics, Heretics, And Zealots, Hampton A. Dodd

Dissertations, Theses, and Capstone Projects

Against technological ubiquity, the philosopher, the ecologist, the theologian, the psychologist, the radical, the reactionary, and the poet have each responded. This analysis seeks to explicate the nature of such responses, as well as to explore their contemporary form and elucidate what those presently publishing might offer as programs toward the future. In order to do this, what follows is broken up into a series of sections, each focused on what I have perceived to be the foremost themes present throughout technological critique: becoming, freedom, identity, faith, space, time, and progress. Prior to such thematic excavations, this analysis offers a …

Large-Scale Investigation Of White Matter Structural Differences In Bilingual And Monolingual Children: An Adolescent Brain Cognitive Development Data Study

Faculty, Staff and Student Publications

Emerging research has provided valuable insights into the structural characteristics of the bilingual brain from studies of bilingual adults; however, there is a dearth of evidence examining brain structural alterations in childhood associated with the bilingual experience. This study examined the associations between bilingualism and white matter organization in bilingual children compared to monolingual peers leveraging the large-scale data from the Adolescent Brain Cognitive Development (ABCD) Study. Then, 446 bilingual children (ages 9-10) were identified from the participants in the ABCD data and rigorously matched to a group of 446 monolingual peers. Multiple regression models for selected language and cognitive …

Rationale And Design Of The Nephrotic Syndrome Study Network (Neptune) Match In Glomerular Diseases: Designing The Right Trial For The Right Patient, Today, Sean Eddy, Wendy R Uhlmann, Cathie Spino, Lawrence B Holzman, John R Sedor, Crystal Gadegbeku, Lalita Subramanian, Chrysta C Lienczewski, Tina Manieri, Scott J Roberts, Debbie S Gipson, Matthias Kretzler, Neptune Investigators

Faculty, Staff and Student Publications

Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) is poised to address these challenges. The study has enrolled >850 pediatric and adult patients with proteinuric glomerular diseases who have contributed to deep clinical, histologic, genetic, and molecular profiles linked to long-term outcomes. The NEPTUNE Knowledge Network, comprising combined, multiscalar data sets, captures each participant's molecular disease processes at the time of kidney biopsy. In this editorial, we …

Association Of Socioeconomic Factors And Severity Of Bronchiolitis Hospitalizations

Faculty, Staff and Student Publications

It is unclear if socioeconomic status (SES) factors influence severity of illness of patients hospitalized with bronchiolitis. This study was conducted to identify SES factors including the Center for Disease Control and Prevention’s Social Vulnerability Composite Index (SVI), estimated income, proportion of minority, proportion of living below poverty, insurance status, and number of household members associated with length of stay (LOS) and intensive care unit admission. Infants hospitalized at a tertiary care urban center for bronchiolitis were identified using International Classification of Diseases codes. Federal information processing system codes were identified from home address and paired with SVI and 2018 …

Acquisition Of Tp63 Rearrangement In Large Cell Transformation Of Mycosis Fungoides, Karen A Nahmod, Guilin Tang, Shaoying Li, Carlos Torres-Cabala, Jie Xu

Faculty, Staff and Student Publications

No abstract provided.