Digital Commons Network^™

Ubiquitous Filter Feeders Shape Open Ocean Microbial Community Structure And Function, Anne W. Thompson, Györgyi Nyerges, Kylee M. Brevick, Kelly Sutherland

Biology Faculty Publications and Presentations

The mechanism of mortality plays a large role in how microorganisms in the open ocean contribute to global energy and nutrient cycling. Salps are ubiquitous pelagic tunicates that are a well-known mortality source for large phototrophic microorganisms in coastal and high-latitude systems, but their impact on the immense populations of smaller prokaryotes in the tropical and subtropical open ocean gyres is not well quantified. We used robustly quantitative techniques to measure salp clearance and enrichment of specific microbial functional groups in the North Pacific Subtropical Gyre, one of the largest ecosystems on Earth. We discovered that salps are a previously …

Computational Discovery Of Microstructured Composites With Optimal Stiffness-Toughness Trade-Offs, Beichen Li, Bolei Deng, Wan Shou, Tae-Hyun Oh, Yuanming Hu, Yiyue Luo, Liang Shi, Wojciech Matusik

Mechanical Engineering Faculty Publications and Presentations

The conflict between stiffness and toughness is a fundamental problem in engineering materials design. However, the systematic discovery of microstructured composites with optimal stiffness-toughness trade-offs has never been demonstrated, hindered by the discrepancies between simulation and reality and the lack of data-efficient exploration of the entire Pareto front. We introduce a generalizable pipeline that integrates physical experiments, numerical simulations, and artificial neural networks to address both challenges. Without any prescribed expert knowledge of material design, our approach implements a nested-loop proposal-validation workflow to bridge the simulation-to-reality gap and find microstructured composites that are stiff and tough with high sample efficiency. …

Biological Aging Markers In Blood And Brain Tissue Indicate Age Acceleration In Alcohol Use Disorder, Gabriel R Fries, Lea Sirignano, Marion M Friske, Bernd Lenz, Sabine Hoffmann, Kristina Adorjan, Falk Kiefer, Georgy Bakalkin, Anita C Hansson, Falk W Lohoff, Olli Kärkkäinen, Eloise Kok, Pekka J Karhunen, Greg T Sutherland, Consuelo Walss-Bass, Rainer Spanagel, Marcella Rietschel, Dirk A Moser, Stephanie H Witt

Faculty, Staff and Student Publications

Background: Alcohol use disorder (AUD) is associated with increased mortality and morbidity risk. A reason for this could be accelerated biological aging, which is strongly influenced by disease processes such as inflammation. As recent studies of AUD show changes in DNA methylation and gene expression in neuroinflammation-related pathways in the brain, biological aging represents a potentially important construct for understanding the adverse effects of substance use disorders. Epigenetic clocks have shown accelerated aging in blood samples from individuals with AUD. However, no systematic evaluation of biological age measures in AUD across different tissues and brain regions has been undertaken.

Methods: …

Towards Sociobiogeochemistry: Critical Perspectives On Anthropogenic Alterations To Soil Nitrogen Chemistry Via U.S. Urban And Suburban Development, Christopher D. Ryan

Dissertations, Theses, and Capstone Projects

The ecological impacts of changes to land use are relevant to concerns about climate change, eutrophication of waterbodies, and reductions in biodiversity. As a foundational component of ecosystem functioning, changes to soil biogeochemistry have significant effects on overall ecosystem health. With cities continuing to grow and develop in extent, the impacts of urbanization and suburbanization on soils are of particular concern. Despite a wide range of natural climatic and geologic conditions, several factors have driven similar patterns of land transformation and management across the United States. In particular, federal initiatives including the Home Owners Loan Corporation, the Federal Housing Administration, …

Developing Autonomy And Identity On Tiktok Among Recently Arrived Latin American Migrants To The United States, Camille D. May

Dissertations, Theses, and Capstone Projects

Latin American migrants, as content creators and consumers, active on the social media platform, TikTok, weave webs of ‘self’ across borders, employing narrative identity as a framework to challenge depictions, build community, and navigate power along the migrant journey. Amidst a dramatic rise in both US-bound and global migration, my analysis examines the interplay between technology and migrant narratives and identities across online and offline spaces. While deportation regimes, migration policies, mainstream technology, and state control over migrant bodies impose limitations, social media emerges as a crucial tool for navigating journeys and constructing identities in transit. This academic review explores …

Cognitive Reserve In Individuals With Frontotemporal Dementia And Primary Progressive Aphasia, Lauren A. Grebe

Dissertations, Theses, and Capstone Projects

Cognitive reserve refers to the brain’s ability to efficiently adapt in the presence of neuropathological disease. This is an active process influenced by individual differences (e.g., genetics) and lifetime experiences (e.g., education, occupation, leisure) (Cabeza et al., 2018; Stern et al., 2020). The cognitive reserve theory has recently been investigated in individuals with frontotemporal dementia (FTD), which refers to various disorders leading to frontotemporal neurodegenerative decline (Young et al., 2018); e.g., behavioral variant of FTD (bvFTD) and variants of Primary Progressive Aphasia (PPA): semantic (svPPA), nonfluent/agrammatic (nfvPPA), and logopenic (lvPPA). However, a clear consensus on the relationship among cognitive reserve, …

What Does One Billion Dollars Look Like?: Visualizing Extreme Wealth, William Mahoney Luckman

Dissertations, Theses, and Capstone Projects

The word “billion” is a mathematical abstraction related to “big,” but it is difficult to understand the vast difference in value between one million and one billion; even harder to understand the vast difference in purchasing power between one billion dollars, and the average U.S. yearly income. Perhaps most difficult to conceive of is what that purchasing power and huge mass of capital translates to in terms of power. This project blends design, text, facts, and figures into an interactive narrative website that helps the user better understand their position in relation to extreme wealth: https://whatdoesonebilliondollarslooklike.website/

The site incorporates …

Park Use, Urban Environmental Justice, And Place Attachment In Parks In Low-Income Neighborhoods In New York City, Javier Eduardo Otero Peña

Dissertations, Theses, and Capstone Projects

This three-article dissertation brings environmental psychology themes and questions to a large-scale public health research project about a subset of community parks and park renovations in low-income neighborhoods in New York City (NYC). What attributes and perceived aspects of the physical and social environment of parks and their neighborhoods are associated with higher park use? How do residents of gentrifying low-income neighborhoods feel about park renovations that took place in their communities? What can be learned from parks, park renovations and place attachment from exploring user-generated content in the Google Maps platform? Each of the articles presented in this dissertation …

Visualizing A Life, Uprooted: An Interactive, Web-Map And Scroll-Driven Exploration Of The Oral History Of My Great-Grandfather – From Ottoman Cilicia To Lebanon And Beyond, Alyssa Campbell

Dissertations, Theses, and Capstone Projects

This project is an interactive data visualization narrative of the oral history of my great-grandfather, Hovsep Aghek Yeni-Komshian, born April 2, 1895 to an Armenian family in Kilis, Cilicia, Ottoman Empire.

Before World War I and the fall of the Ottoman Empire, millions of Armenians lived throughout what is today Eastern Turkey, their nearly 3000-year history in the region making them one of the oldest indigenous groups of the area. However, today the Armenian presence in Anatolia has largely been erased due to the Armenian Genocide (1915-1923), during which nearly the entire local Armenian population was murdered or forcibly deported …

Integration Of Field- And Space-Based Observations Toward Assessing Drivers Of Biogeochemical Variability Across Vulnerable Coastal Ecosystems, Alana B. Menendez

Dissertations, Theses, and Capstone Projects

This thesis uses new field datasets and satellite ocean color products to quantify biogeochemical variability in three coastal regions: Long Island Sound estuary, the coastline of the Bay of Bengal extending east to the Mekong Delta, and the Yukon River Delta. These three study regions have vastly different size domains, climates, populations, and economies, but all require enhanced coastal water monitoring in the face of climate change. These regions are all naturally dynamic and experience strong seasonal phenomena but are also subject to changing hydrological forcings and direct anthropogenic perturbations. This leaves these coastal areas vulnerable to altered biogeochemical cycling, …

Comprehension And Production Of Contrastive Reference In Autism, Georgia Drakopoulou Kalantzi

Dissertations, Theses, and Capstone Projects

Autistic children often exhibit differences in their use of referring expressions during discourse, characterized by the production of ambiguous expressions or the tendency to provide too little or too much information. Although several studies have investigated the social communicative behavior of autistic children, fewer have examined the pragmatic aspects of reference and how these are related to their cognitive and general language abilities. Moreover, the majority of studies have focused on the production of pronominal reference in narratives, with fewer exploring contrastive reference, particularly in comprehension. The current study aims to address these questions by investigating both the comprehension and …

Making And Unmaking Multiethnic Black Neighborhoods: Immigration, Race, And Gentrification In New York And Paris, Maura Mcgee

Dissertations, Theses, and Capstone Projects

This dissertation is a transatlantic comparative study of gentrification in multiethnic Black neighborhoods in New York and Paris. It draws on neighborhood case studies conducted in Crown Heights in Brooklyn and la Goutte d’Or in Paris, home respectively to African ancestry immigrant communities from the Caribbean and Sub-Saharan Africa. It looks specifically at the causes and consequences of changes in neighborhood social spaces—the commercial landscape and social institutions—rather than at shifts in residential patterns.

Three main questions guide this research. First, what roles do race and immigration play in the process of gentrification, which has historically been most prevalent in …

Unnatural Issue: Gendered Adaptations Of “Peau D’Âne” In Contemporary French And English Texts, Amy M. Martin

Dissertations, Theses, and Capstone Projects

Unnatural Issue: Gendered Adaptations of “Peau d’Âne” in Contemporary French and English Texts explores trans-genre and transmedia adaptations of Charles Perrault’s seventeenth-century fairy tale using feminist and narratological theories to examine gendered aspects of storytelling and the treatment of father-daughter incest and blame in the work of selected French, British, and American creators. Texts are read comparatively, with analyses of the adaptations’ plots, motifs, characterizations, and modifications, both in relation to Perrault and to the other adaptations. This dissertation features prose and poetry texts by female authors—including Christine Angot, Catherine Cusset, and Emma Donoghue—in the first two chapters. Reading these …

Spain's Vision Of Empire Through Conquest, Ideology, And Law In The Sixteenth Century, Penelope Yau-Wen

Dissertations, Theses, and Capstone Projects

This thesis examines how the process of exploration, discovery, conquest and colonization of the Americas by Spain developed along with a vision of empire that involved the formulation of political theories, laws and policies by the governing elites, while responding to the actions by the conquistadors on the field. Although events on both sides of the Atlantic were not necessarily coordinated, the interests of the Court and the conquistadors intersected and were justified through a discourse that had been shaped by Humanist intellectual currents.

The thesis intends to show how the Castilian imperial vision was an experiment that began to …

Studies Of Oxidopyrylium Ylide Dimers And Their Utility In The Synthesis Of Densely Functionalized Troponoids, Daniel V. Schiavone

Dissertations, Theses, and Capstone Projects

Herein, we describe our efforts to investigate mechanistic considerations of oxidopyrylium ylides and their use in cycloadditions to form complex bicyclic structures and the advancement of these cycloadducts to the synthesis of densely functionalized tropolones. This work also describes applications of tropolones as biologically relevant structures and dynamic fluorophores.

In Chapter 1, we expand upon previous studies done in the Murelli Lab describing the ability of 3-hydroxy-4-pyrone derived oxidopyrylium dimers to revert back to ylides in situ and as result can be used as a clean oxidopyrylium ylide source in accessing oxabicyclic compounds. Intermolecular cycloadditions of these ylides can be …

Gut Microbiome Of Patients With Breast Cancer In Vietnam, Hui Cai, Chu V Nguyen, To V Ta, Jie Wu, Qiuyin Cai, Wei Zheng, Thuan V Tran, Xiao-Ou Shu

Faculty, Staff and Student Publications

PURPOSE: Gut microbiota play an important role in human health, including cancer. Cancer and its treatment, in turn, may alter the gut microbiome. To understand this complex relationship, we profiled the gut microbiome of 356 Vietnamese patients with breast cancer.

MATERIALS AND METHODS: Stool samples were collected before chemotherapy, with 162 pre- and 194 postsurgery. The gut microbiome was measured by shotgun metagenomic sequencing. Associations of gut microbial diversity, taxa abundance, and gut microbiome health index (GMHI) with sociodemographic, clinical factors, and tumor characteristics were evaluated.

RESULTS: Postsurgery samples were associated with significantly lower α- and β-diversities (

CONCLUSION: Our …

Impact Of Neighborhood Disadvantage On Tumor Biology And Breast Cancer Survival, Steve Cole

Faculty, Staff and Student Publications

Objective: The aim of this study was to evaluate the association between neighborhood disadvantage and Oncotype DX score, a surrogate for tumor biology, among a national cohort.

Background: Women living in disadvantaged neighborhoods have shorter breast cancer (BC) survival, even after accounting for individual-level, tumor, and treatment characteristics. This suggests unaccounted social and biological mechanisms by which neighborhood disadvantage may impact BC survival.

Methods: This cross-sectional study included stage I and II, ER + /HER2 - BC patients with Oncotype DX score data from the National Cancer Database (NCDB) from 2004 to 2019. Multivariate regression models tested the association of …

A Surgical Desirability Of Outcome Ranking (Door) Reveals Complex Relationships Between Race/Ethnicity, Insurance Type, And Neighborhood Deprivation, Lillian S Kao, Hoah-Der Su, Jonathan C Silverstein, Paula K Shireman

Faculty, Staff and Student Publications

Objective: Develop an ordinal Desirability of Outcome Ranking (DOOR) for surgical outcomes to examine complex associations of Social Determinants of Health.

Background: Studies focused on single or binary composite outcomes may not detect health disparities.

Methods: Three health care system cohort study using NSQIP (2013-2019) linked with EHR and risk-adjusted for frailty, preoperative acute serious conditions (PASC), case status and operative stress assessing associations of multilevel Social Determinants of Health of race/ethnicity, insurance type (Private 13,957; Medicare 15,198; Medicaid 2835; Uninsured 2963) and Area Deprivation Index (ADI) on DOOR and the binary Textbook Outcomes (TO).

Results: Patients living in highly …

Assessment Of Patient Satisfaction And Treatment Outcomes In Digital Smile Design Vs Conventional Smile Design: A Randomized Controlled Trial, Nishu Kumari

Faculty, Staff and Student Publications

BACKGROUND: The esthetics of a smile holds significant importance in an individual's self-esteem and overall quality of life. In the realm of cosmetic dentistry, smile design has traditionally relied on conventional methods, but recent advances in technology have introduced digital smile design (DSD) as a promising alternative.

MATERIALS AND METHODS: In this randomized controlled trial, 150 adult patients seeking smile enhancement procedures were enrolled and randomly assigned to one of two groups: the DSD group or the conventional smile design group. The DSD group underwent smile design using digital technology, including intraoral scans, computer-aided design, and 3D simulations. Meanwhile, the …

Girth-Based Administered Activity For Pediatric 99mtc-Dmsa Spect, Michael Ghaly, Frederic H Fahey, Wesley Bolch, George Sgouros, Eric C Frey

Faculty, Staff and Student Publications

Background: Pediatric molecular imaging requires a balance between administering an activity that will yield sufficient diagnostic image quality while maintaining patient radiation exposure at acceptable levels. In current clinical practice, this balance is arrived at by the current North American Consensus Guidelines in which patient weight is used to recommend the administered activity (AA).

Purpose: We have previously demonstrated that girth (waist circumference at the level of the kidneys) is better at equalizing image quality than patient weight for pediatric Tc-99m DMSA renal function imaging. However, the correlation between image quality (IQ), AA, and patient girth has not been rigorously …

Evaluation Of The Effectiveness Of Telemedicine In Postoperative Follow-Up Care After Dental Implant Surgery A Pilot Study, Sonal Singh

Faculty, Staff and Student Publications

AIM: Telemedicine has emerged as a potential solution to enhance postoperative follow-up care after dental implant surgery, offering the convenience of remote monitoring and reduced need for in-person visits.

MATERIALS AND METHODS: Participants were randomly assigned to either the telemedicine group (n = 15) or the in-person group (n = 15). In the telemedicine group, patients received remote follow-up care through virtual consultations, during which they could communicate their concerns and share images of the surgical site. The in-person group received standard in-person follow-up visits. Patient satisfaction was measured using a standardized survey, with responses collected on a Likert scale. …

Burden Of Dog Bite Injuries And Wound Management Practices To Prevent Rabies Among Dog Owners

Faculty, Staff and Student Publications

BACKGROUND: Despite members of dog-owning families being at a higher risk of dog bites owing to their proximity to dogs in their household, there are hardly any studies from India which focus on the burden of dog bites among them and their rabies control and prevention practices. This study aimed to estimate the burden of dog bites among dog owners and their wound management practices to prevent rabies.

MATERIALS AND METHODS: A cross-sectional study was conducted among pet dog owners in a high-end housing society of National Capital Region of Delhi. A pre-tested and pre-validated schedule was used to collect …

Safety And Academic Outcomes Of College Campus-Based Advocacy Services, Leila Wood

Faculty, Staff and Student Publications

Intimate partner violence (IPV), sexual assault, and stalking are consequential public health and safety issues with wide reaching impacts on emerging adults, including those on college campuses in the United States. In response to high rates of violence among college student populations, universities are developing campus-based advocacy (CBA) programs, which aim to support survivors of interpersonal violence through supportive connections, resource acquisition, and safety planning. However, little data exists related to their impact on key student-survivor outcomes. Thus, this study aims to understand (a) the approach CBA programs use to address safety and academic concerns of student-survivors, and (b) the …

Impact And Efficiency Of Treatment Across Two Ptsd Clinical Trials Comparing In-Person And Telehealth Service Delivery Formats, John C Moring, Ron Acierno, Sheila A M Rauch, Jim Mintz, Donald D Mcgeary, Stephanie Y Wells, Kathleen Grubbs, Paul S Nabity, Chelsea J Mcmahon, Brett T Litz, Dawn I Velligan, Alexandra Macdonald, Emma Mata-Galan, Stephen L Holliday, Kirsten H Dillon, John D Roache, Alan L Peterson

Faculty, Staff and Student Publications

The intent of this study is to examine treatment impact and efficiency observed when cognitive behavioral treatments for posttraumatic stress disorder (PTSD) are delivered in-person or using telehealth. This study pooled data from 268 veterans enrolled in two PTSD clinical trials. In both trials, treatment was delivered using in-home telehealth (telehealth arm), in-home in-person (in-home arm), and in-office care, where patients traveled to the Department of Veterans Affairs for either office-based telehealth or office-based in-person care (office arm). Average age was 44 (SD = 12.57); 80.9% were males. The PTSD Checklist for DSM-5 (PCL-5) was used …

Cryptic Bacterial Pathogens Of Diatoms Peak During Senescence Of A Winter Diatom Bloom, Laura Branscombe, Ellen L. Harrison, Zhi Yi Daniel Choong, Courtney Swink, Matthew Keys, Claire Widdicombe, William H. Wilson, Michael Cunliffe, Katherine Helliwell

School of Biological and Marine Sciences

Summary.Diatoms are globally abundant microalgae that form extensive blooms in aquatic ecosystems. Certain bacteria behave antagonistically towards diatoms, killing or inhibiting their growth. Despite their crucial implications to diatom bloom and population health, knowledge of diatom antagonists in the environment is fundamentally lacking. We report systematic characterisation of the diversity and seasonal dynamics of bacterial antagonists of diatoms via plaque assay sampling in the Western English Channel, where diatoms frequently bloom. Unexpectedly, peaks in detection did not occur during characteristic spring diatom blooms, but coincided with a winter bloom of Coscinodiscus, suggesting that these bacteria likely influence distinct diatom host …

Deciphering The Intricate Hierarchical Gene Regulatory Network: Unraveling Multi-Level Regulation And Modifications Driving Secondary Cell Wall Formation, Zhigang Wei, Hairong Wei

Michigan Tech Publications

Wood quality is predominantly determined by the amount and the composition of secondary cell walls (SCWs). Consequently, unraveling the molecular regulatory mechanisms governing SCW formation is of paramount importance for genetic engineering aimed at enhancing wood properties. Although SCW formation is known to be governed by a hierarchical gene regulatory network (HGRN), our understanding of how a HGRN operates and regulates the formation of heterogeneous SCWs for plant development and adaption to ever-changing environment remains limited. In this review, we examined the HGRNs governing SCW formation and highlighted the significant key differences between herbaceous Arabidopsis and woody plant poplar. We …

Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han

Michigan Tech Publications

Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction-a measure of …

Low Shear In Short-Term Impacts Endothelial Cell Traction And Alignment In Long-Term, Mohanish K. Chandurkar, Nikhil Mittal, Shaina P. Royer-Weeden, Steven D. Lehmann, Yeonwoo Rho, Sangyoon J. Han

Michigan Tech Publications

Within the vascular system, endothelial cells (ECs) are exposed to fluid shear stress (FSS), a mechanical force exerted by blood flow that is critical for regulating cellular tension and maintaining vascular homeostasis. The way ECs react to FSS varies significantly; while high, laminar FSS supports vasodilation and suppresses inflammation, low or disturbed FSS can lead to endothelial dysfunction and increase the risk of cardiovascular diseases. Yet, the adaptation of ECs to dynamically varying FSS remains poorly understood. This study focuses on the dynamic responses of ECs to brief periods of low FSS, examining its impact on endothelial traction—a measure of …

Cfd Analysis Of Multi-Stage Phase Change Material For Latent Thermal Energy Storage In Solar Power Plants, Ahmad Wahbi Omari

Theses

The integration of latent thermal energy storage into concentrated solar power plants represents a promising solution for efficiently harnessing excessive solar energy during daylight hours and subsequently utilizing it during the nighttime when solar energy generation is limited or non-existent, all while catering to consistent energy demands. The core objective of enhancing latent thermal energy storage revolves around elevating its thermal capacity and minimizing the melting time, thus making it a more effective energy storage solution. This is achieved by employing three distinct organic phase change materials: Octadecanoic (PCM1), RT58 (PCM2) and Dodecanoic (PCM3), each characterized by variations in their …

Investigating The Mass Mortality Induced Factors Of Pearl Oyster (Pinctada Radiata) At Abu Dhabi Pearls Farm, Uae, Hamad Ahmed Almansoori

Theses

The aquaculture of shellfish plays a crucial role in enhancing maritime environments by mitigating algal blooms and improving water quality through the filtration of organic matter, nutrients, and bacteria. This study investigated the environmental factors influencing oyster (Pinctada radiata) mortalities through a comprehensive analysis of water quality in Al Mirfa and Al Mughirah farming sites of Abu Dhabi (UAE), from February 2021 to February 2022. To reach such understanding of the main factors led to mass mortalities of cultivated oysters, different monthly sampling and both chemical and biological analyses of the farm water, sediments as well as for both living …