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Consistency Of Advanced Radiation Therapy Qa Methods And Global Auditing Systems, Fre'etta Brooks

Dissertations and Theses (Open Access)

Consistency of Advanced Radiation Therapy QA Methods and Global Auditing Systems

Fre’Etta M.D. Brooks, B.S.

Advisory Professor: Stephen F. Kry, Ph.D.

Abstract

Auditing systems provide a means to verify the implementation and operation of all equipment and radiation parameters used by an institution providing radiation therapy treatments. The systems are important tools that are used to determine if an institution can accurately deliver radiation therapy that requires complex planning in the form of IMRT or VMAT and credential radiotherapy treatment institutions for specific clinical trial protocols; to assure the quality of treatment to all patients. Auditing techniques vary by region …

Delineating Metastasis In Mss Colorectal Cancer By Single - Cell Rna Sequencing, Shuangjie You

Dissertations and Theses (Open Access)

Colorectal cancer Colorectal Cancer (CRC) is the leading cause of cancer-related deaths, with the majority of these deaths occurring after metastases. In this study, we used single-cell RNA transcriptome sequencing to characterize the cellular and molecular features of primary CRC and colorectal liver metastases (CRLM). Analysis of 130 samples revealed significant heterogeneity in the tumor microenvironment (TME) characterized by a diversity of cancer-associated fibroblasts, immune cells, and endothelial cell populations. Notably, we identified different CAF subtypes, including inflammatory (iCAFs), matrix(mCAFs), complement (cCAFs), and vascular (vCAFs). iCAFs were enriched in primary tumors expressing higher levels of inflammation-associated genes, whereas mCAFs were …

Early Onset Alzheimer’S Disease Markers In Mouse Hippocampus Unveiled By Single-Cell Transcriptomic Analysis Following Cranial Radiotherapy, Tuba Aksoy

Dissertations and Theses (Open Access)

Cranial radiation therapy plays an integral role in the treatment of brain tumors but can lead to progressive cognitive deficits in survivors by mechanisms that are poorly understood. To develop preventive or mitigative strategies, it is crucial to better understand the underlying pathogenesis of radiation-induced cognitive impairments. The study investigated single-cell transcriptomics and DNA methylation changes as potential drivers of persistent cellular dysfunction after radiation exposure, specifically concentrating on the CA1-3 regions of the hippocampus and the prefrontal cortex due to their role in cognitive functions. Thirteen-week-old mice underwent whole-brain radiation at clinically relevant doses. Following whole-brain radiation, an assessment …

Exploring The Role Of The Arginine-Methylation Writer-Reader Pair Prmt5/Snd1 In Jak2-Mutant Myeloproliferative Neoplasms, Rocio Rubiano

Dissertations and Theses (Open Access)

Myeloproliferative neoplasms (MPNs) are a hematopoietic disease characterized by hyperproliferation of cells of the myeloid lineage for which current therapeutic options are limited. Discovered in 2005, the JAK2V617F mutation is the most common driver mutation in BCR-ABL negative MPNs, resulting in constitutive activation of the JAK2 protein and the JAK-STAT signaling pathway. A role for the methyltransferase activity of Protein Arginine Methyltransferase 5 (PRMT5) has been proposed in JAK2-mutant MPN, highlighting both a mechanism through which this mutation can drive disease progression and a potential mode of therapeutic intervention. Staphylococcal Nuclease Domain-Containing Protein 1 (SND1) is the effector molecule responsible …

Influential Factors And Predicting Dose Delivery Accuracy For Imaging And Radiation Oncology Core’S Phantom Program Using Machine Learning, Hunter Mehrens

Dissertations and Theses (Open Access)

IROC’s mission is to help ensure consistent and comparable, high-quality radiotherapy across clinics that participate in national clinical trials. To obtain this mission, IROC’s phantom program provides a third-party end-to-end check of the clinical workflow of a patient receiving radiotherapy. The goal of the phantom audit is to compare the dose delivered to the dose planned by the treatment system ensuring dose delivery accuracy. While IROC’s phantoms are better equipped to catch dose delivery errors compared to a clinic’s QA process, the end-to-end process and reporting of results is time-consuming creating a bottleneck for clinical trial participation. Furthermore, IROC’s passing …

The Role Of An Ultraconserved Long Non-Coding Rna In B-Cell Lymphomagenesis, Swati Mohapatra

Dissertations and Theses (Open Access)

Ultraconserved regions (UCRs) are genomic segments with perfect (100%) conservation between the orthologous regions of human, rat, and mouse genomes. UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of non-coding RNA (ncRNA) transcripts. NcRNAs play crucial roles in cellular processes, including oncogenic transformation, with emerging evidence revealing their ability to encode small peptides known as ncRNA-encoded peptides (ncPEPs). These peptides, originating from small open reading frames (smORFs), contribute to diverse cellular functions and …

Evaluation Of Myogenic Differentiation Potential Of Bmd Ipscs In Vitro And The Effect Of Ubiquitination Inhibitors On Dystrophin Stability In Vivo, Muchen Liu

Dissertations and Theses (Open Access)

Background: Muscular dystrophies are heterogeneous groups of inherited diseases leading to progressive muscular weakness and degeneration. In the case of Becker muscular dystrophy (BMD), non-disrupting mutations of the DMD gene reading frame is the causative defect. By the age of 30s, about 60 to 70% of BMD patients develop cardiomyopathy, which is often lethal. Unfortunately, there is currently no cure for BMD. Meanwhile, improvement of dystrophin stability by repressing polyubiquitination is a promising strategy. The application of human iPSCs in tissue regeneration also serves as a potential therapeutic strategy. This study aims to test the efficacy of selected drugs interfering …

In Vivo Examination Of Peripheral Drivers Of Alzheimer’S Disease, Celso Catumbela

Dissertations and Theses (Open Access)

Alzheimer’s disease (AD) is the leading cause of dementia worldwide, and predominantly affects elderly populations. This disease is well known for its effects on the brain, but a wealth of clinical reports show that dementia can also modify, or be modified by, various peripheral and systemic processes. Yet, the pathological contribution of peripheral comorbidities to AD remains to be fully understood. In an attempt to address some knowledge gaps, we characterized the cerebral and peripheral pathology in mice with history of either liver injury or sepsis. In the former subjects, we found that even in the absence of genetic risk …

The Effect Of Context Diversity In Virtual Reality Environments On Speech Motor Learning In A Person With Aphasia And Apraxia Of Speech, Shelby Keeler Holloway

Theses and Dissertations

This study explored the effect of contextual diversity on speech motor learning in an individual with apraxia of speech (AOS) using virtual reality (VR). One 62-year-old participant with severe AOS participated in the study where he practiced monosyllabic CVC words in both consistent and diverse VR environments. Kinematic, acoustic, and perceptual data were collected and evaluated for evidence of learning. Kinematic data were collected using electromagnetic articulography where sensors were glued to the participant's upper lip, lower lip, tongue blade, and tongue tip and were tracked with high precision. In addition, acoustic and perceptual data were collected using a microphone …

How Fun Overcame Fear: The Gamification Of A Graduate-Level Statistics Course, Mai P. Trinh, Robert J. Chico, Rachel M. Reed

Management Faculty Publications

Innovative instructional methods can help improve student engagement and learning outcomes when teaching difficult subjects, such as statistics. This instructional innovation article illustrates how gamification can be applied in management education to improve students’ learning experience, engagement, and acquisition of knowledge. Our purpose is to demonstrate how gamification is not only a powerful way to build on the use of games and game thinking in our field, but also a versatile application of education technology that could potentially enhance the way management knowledge is taught. Furthermore, it is a low-risk way for management educators to join and contribute to the …

Large-Scale Hpc-Empowered Power Electronics Modeling And Simulation In Photovoltaic Applications, Liwei Wang

All Dissertations

The rising popularity of renewable energy sources requires advanced, efficient power electronic systems for energy conversion, grid integration, and system management, thereby raising expectations for power electronics in the energy industry. The complexity of modern power electronic systems requires comprehensive simulations and in-depth analysis to predict performance accurately, but this process is impeded by prolonged simulation times. The primary objective of this dissertation is to develop a high-fidelity, high-speed event-driven simulator to tackle challenges related to mass data processing, uncertainty evaluation, as well as modeling and simulation issues in assessing the reliability of power electronics in large-scale Photovoltaic (PV) systems. …

Investigating Institutional Support For A Minority Engineering Program At A Historically White Institution, Stephanie Damas

All Dissertations

Engineering programs at historically White institutions (HWIs) often perpetuate stereotypes and racism against Black students, impacting their experiences and opportunities in the field. Minority engineering programs (MEPs) provide support and resources to minority students in engineering, challenging stereotypes and fostering positive identity development. MEPs push back on cultural norms by rejecting the stereotypical narrative of what it means to be Black in engineering. Despite their significance, MEPs face challenges in garnering institutional support and recognition within engineering departments. It is imperative to understand what institutional support for MEPs looks like to mitigate barriers identified in the literature. To address these …

Voices From The Countryside: Unveiling The Stories Of Rural Teachers In Stem Education, Devan A. Jones

All Dissertations

This narrative study delves into the overlooked perspective of rural communities within the broader educational landscape, highlighting their unique and vital role in education. It primarily aims to gain insights from K-8 teachers working in multigrade, multi-curricular Sustained Deep Rurality (SDR) schools situated in the challenging terrain of the Northern Rocky Mountain area. Employing a methodology centered around episodic narrative interviews and small story analysis, the study uncovers the intricacies and challenges inherent in teaching under the extreme conditions of rural environments.

These SDR schools, situated in remote and isolated regions, serve as vital pillars in rural education, embodying qualities …

Ultra High-Performance Concrete As A High Friction Surface Treatment For Pavements And Bridges, Kyle Maeger

All Dissertations

High Friction Surface Treatment (HFST) is a proven technology to reduce crashes on roadways by increasing the coefficient of friction between vehicle tires and the pavement. However, it is an expensive solution due to the high cost of the two commonly used constituent materials, calcined bauxite aggregate and epoxy resin binders.

This study evaluated the abrasion resistance performance of four alternative HFST aggregates to calcined bauxite using Los Angeles Abrasion and Micro-Deval Abrasion tests, and studied the surface texture utilizing a high-resolution laser scanner and friction utilizing the British Pendulum Test.

This study also assessed the performance of non-proprietary Ultra …

Probabilistic Frames And Concepts From Optimal Transport, Dongwei Chen

All Dissertations

As the generalization of frames in the Euclidean space $\mathbb{R}^n$, a probabilistic frame is a probability measure on $\mathbb{R}^n$ that has a finite second moment and whose support spans $\mathbb{R}^n$. The p-Wasserstein distance with $p \geq 1$ from optimal transport is often used to compare probabilistic frames. It is particularly useful to compare frames of various cardinalities in the context of probabilistic frames. We show that the 2-Wasserstein distance appears naturally in the fundamental objects of frame theory and draws consequences leading to a geometric viewpoint of probabilistic frames.

We convert the classic lower bound estimates of 2-Wasserstein distance \cite{Gelbrich90, …

Time-Domain Line Protection In Presence Of Renewables, Prabin Adhikari

All Dissertations

Inverter based resources (IBRs) are crucial in integrating renewable energy sources into the power grid. However, their unique fault characteristics, significantly different from synchronous generators (SGs), present several challenges for existing line protection schemes at both transmission and distribution levels. These schemes, reliant on distance and directional relays designed in phasor domain, are not well-suited for IBRs. Most published literature addressing this problem concentrates on altering the control design of inverters. However, this approach faces practical limitations. Inverter controls, often proprietary, are not readily accessible to utilities, rendering the control-based solutions impractical for widespread implementation.

To address this challenge, this …

Fluid-Solid Coupled Analysis Of Biological Samples In A Flow Chamber Using Optical Coherence Tomography, Reece W. Fratus

All Dissertations

Forces from fluid flow on a tissue or cellular boundary can drive remodeling processes through mechanotransduction pathways. In most cases, the exact mechanisms are not understood, such as in marine biofilm development or vascular remodeling. To gain a better understanding of these interactions, the flow profile at a solid boundary and the mechanical changes of that solid can be coupled together to determine the impact of fluid flow on mechanical remodeling. To achieve this, optical coherence tomography (OCT) is used to image the fluid and solid simultaneously. Fluid seeded with particles can be imaged and run through a particle image …

Don't Waste Our Time: Key Transformative Structures For Fast Track Learning, Carlita S. King

All Dissertations

Following a massive wave of school closures during the COVID-19 pandemic, educators found the need to be hyper-critical of how they spend their instructional time with students. Almost all students are expected to return nearly a full grade-level behind and would likely have to learn to navigate a completely new school environment. As a result, many educators were overwhelmed to cover unprecedented amounts of instructional content in less time. High-intensity tutoring programs have been known to have the potential to help struggling students advance their skills and gain up to three additional months of learning within a few sessions. The …

Fundamental Study Of Nonlinear Electrophoresis, Joseph Armakan Bentor

All Dissertations

Classical electrophoretic theory describes the linear response of particles suspended in Newtonian fluids under weak electric fields. When the electric field exceeds this weak limit, a nonlinear response arises due to non-uniform surface conduction over the curved particles. This nonlinear behavior introduces dependencies on fluid and particle properties not considered in the classical theory, offering potential advantages for microfluidic particle manipulation. While this phenomenon has been extensively studied theoretically and numerically in Newtonian fluids, experimental investigations have been relatively limited.

Fluid rheology can significantly alter particle dynamics under applied electric fields. Rheological properties like shear-thinning and elasticity which are not …

Effect Of Long-Term Use Of Antimicrobials On Commonly Used Surfaces In Foodservice Establishments, Anuradhi Bandaranayake

All Dissertations

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Brought What I Needed To Succeed: Community Cultural Wealth In The Persistence Experiences Of Former Division Ii Black Women Basketball Players Who Graduated From Predominantly White Institutions, Tomiko T. Smalls

All Dissertations

Limited research exists to examine the persistence experiences of Black women student-athletes who graduated from predominantly White institutions and to explore their experiences at institutions with Division II membership. This purpose of this study was to examine factors related to the positive graduation outcomes of Black women student-athletes who graduated from predominantly White institutions. The research question was: How did former Division II Black women basketball players engage community cultural wealth to persist to graduation at predominantly White institutions? Five former Division II basketball players who graduated from predominantly White institutions located in the southeastern region of the United Stated …

Electrochemical Characteristics Of Bio-Derived And Silicon-Based Materials For Lithium Ion And Lithium Sulfur Batteries, Nawraj Sapkota

All Dissertations

The increasing demand for advanced batteries, driven by automotive and energy storage needs, emphasizes the need for improved energy density, longevity, and cost-effectiveness. While lithium-ion batteries (LIBs) offer high energy density, their traditional anode and cathode materials are reaching their limits. Innovations in battery chemistry, particularly using sulfur cathodes and silicon-based anodes, are crucial. Sulfur and silicon are attractive due to their abundance, environmental friendliness, and higher theoretical capacities. This research aims to enhance the electrochemical performance of lithium-sulfur batteries using three-dimensional architectures and solid-state electrolytes, and to improve silicon-based materials by modifying their surface architectures.

Chapter 1 reviews the …

Mental Health Of Healthcare Workers In Kosovo During The Covid-19 Pandemic, Latif Hoxha

All Dissertations

ABSTRACT

This study explored the mental health of healthcare practitioners in Kosovo during the COVID-19 pandemic, focusing on the prevalence of stress, depression, and anxiety, and the associated individual, family, and work-related factors. The research employed a cross-sectional design with a sample of 449 healthcare workers from two hospitals in Kosovo. The Depression, Anxiety, and Stress Scale (DASS-21) was used to assess mental health symptoms, while socio-demographic and work-related information was collected through a questionnaire.

Based on the descriptive statistics of DASS-21 scores, the prevalence of mental health issues among the participants included high levels of depression (18%), anxiety (25%), …

Contribution Of Collagen Type I To The Mechanical Properties Of Myocardial Tissues At The Micron Level, Adam Baker

All Dissertations

Collagen is a critical component of the organization and one of the key factors contributing to the mechanical stability of the myocardium. Where cardiomyocytes actuate to contract the heart and deliver blood to the lungs and the entire body, the local collagen network must be able to support the mechanical needs of the heart by enhancing rigidity, reducing the mechanical responsibility of cells, and increasing compliance to add loading capacity during diastole. At an organ-wide level, this has been measured and modeled in many ways. At the tissue level, the mechanical properties have been evaluated using techniques such as bi-axial …

Everyday Ingroup Colourism And Racial Esteem: Investigating The Moderating Role Of Assimilation To A Nationalistic Identity Among Afro And Indo Trinidadians, Jenneil Charles

All Dissertations

Colourism is a form of prejudice based on skin tone that occurs intraracially among communities of colour. Whereas light-skin tones are highly favoured, dark-skin tones are privileged in terms of perceived ethnic authenticity and legitimacy, thus, leading to assumptions about greater group level support and resources for dark-skinned persons. This study challenges these assumptions on the premise of ingroup colourism jeopardizing the relationship between Afro and Indo Trinidadians, and their racial-ethnic groups based on the tenets of Social Identity Theory and Social Identity Threat Theory. Social Identity Threat Theory proposes that the response to rejection from one’s ingroup depends on …

Lab To Leadership: How Do Women College Stem Students’ Classroom Experiences Inform Their Leader Identity Development?, Meredith Mcdevitt

All Dissertations

This dissertation is an exploration of leader identity development and women in science, technology, engineering, and mathematics (STEM) college academic classrooms. While there continues to be research promoting diversity in STEM professions, women remain underrepresented in STEM disciplines, leadership positions, and for this specific study, the college academic classroom. This dissertation represents an opportunity for women in STEM college students to reflect on their experiences in STEM academic spaces and communities, while self-exploring factors that shape their leader identity development. The research utilized a basic qualitative research design to understand the participant’s authentic experiences within the academic environment. Conducting semi-structured …

Assessment Of Tce And Chiral Pcb Dechlorination Rate, Congener Diversity, And Enantioselectivity In Town Creek, Sc, Usa Sediment Microcosms, Catherine P. Sumner

All Dissertations

Polychlorinated biphenyls (PCBs) and trichloroethene (TCE) are ubiquitous contaminants and are recognized as persistent organic pollutants due to their extreme chemical stability. PCBs were manufactured by chlorinating biphenyls that created 209 congeners with various structures, of which 19 are chiral and can exist as a pair of stable atropisomers. PCBs have been known to cause developmental and neurological toxicity in humans and wildlife; they can act as endocrine disrupters, carcinogens, and teratogens. Sangamo Weston Inc. was an industrial plant located near Town Creek in Pickens Country, South Carolina, that manufactured capacitors and used Aroclors 1016 and 1254 as dialectic fluids …

Cyber Threats, Cyber Risks, And Cybersecurity Responses: Modeling Whole-Of-Nation Strategy Implementation For American Organizations And Citizens, Vincent Leon Guerrero

All Dissertations

Amid a landscape of cyber attacks on America occurring below the threshold of armed conflict, strategic national policy efforts recommend a whole-of-nation approach where individuals and public and private organizations increase their defensive posture in cyberspace. Motivation to address the risk of a cyber event includes a continuum of cyber threats that can range from low-level disruptive events to cybercrime and cyber espionage to the possibility of a potentially catastrophic attack on critical infrastructure. In this dissertation, I conduct a survey experiment of various cyber threat conditions and cyber policies to model cybersecurity responses, risk perceptions to a possible cyber …

Ensuring The Privacy Compliance Of Voice Personal Assistant Applications, Song Liao

All Dissertations

Voice Personal Assistants (VPA) such as Amazon Alexa and Google Assistant are quickly and seamlessly integrating into people’s daily lives. Meanwhile, the increased reliance on VPA services raises privacy concerns, such as the leakage of private conversations and sensitive information. Privacy policies play an important role in addressing users’ privacy concerns and developers are required to provide privacy policies to disclose their apps’ data practices. In addition, voice apps targeting users in European countries are required to comply with the GDPR (General Data Protection Regulation). However, little is known about whether these privacy policies are informative and trustworthy on emerging …

An Improvement Science Study On The Impact Of Community Building Circles On Teacher Efficacy And Discipline Referrals For African American Males, Katrina J. Bigham

All Dissertations

African American males receive a disproportionate number of referrals that result in punitive and exclusionary consequences. These referrals are often more subjective and include reasons such as disrupting class, disrespect, and refusal to obey. In- and out-of -school suspensions lead to a loss of instructional time for students, as well as a disengagement and lack of belonging for African American males. This dissertation in practice used an improvement science design to examine the problem of practice as related to discrepancies in referrals in a rural district in the southeast. This study aimed to determine the role that Community Building Circles, …