Digital Commons Network^™

Beyond Standard Treatment: A Qualitative Descriptive Study Of Cancer Patients' Perceptions Of Hypnotherapy In Cancer Care, Malwina Szmaglinska, Lesley Andrew, Debbie Massey, Deborah Kirk

Research outputs 2022 to 2026

Background and purpose: Cancer remains a leading cause of death in Australia. The number of new cancer cases diagnosed each year is expected to surpass 200,000 by 2033. This marks a significant increase from about 88,000 cases in 2000 to an estimated 165,000 cases in 2023. Despite advancements in treatment, emotional and psychological challenges in cancer care are often overlooked. This study focuses on hypnotherapy, a complementary therapy recognized for its efficacy for physical and emotional symptoms, yet underutilized in Australian cancer care. The research aims to explore patients' perceptions of hypnotherapy and identify barriers to its integration, contributing to …

Dual Modification Of Reverse Osmosis Membranes With Nh2-Mil-125 And Functionalised Multiwalled Carbon Nanotubes For Enhanced Nanoplastic Removal, Javad Farahbakhsh, Mohadeseh Najafi, Mitra Golgoli, Seyedeh Zahra Haeri, Mehdi Khiadani, Amir Razmjou, Masoumeh Zargar

Research outputs 2022 to 2026

The present study describes a novel double-modified strategy for developing high-performance thin-film composite reverse osmosis (TFC-RO) membranes by incorporating titanium-based metal organic frameworks (NH2-MIL-125) and functionalised multiwalled carbon nanotubes (MWCNTs) into the support layer and selective layer, respectively. Initially, the support layer was subjected to successive modifications using NH2-MIL-125 mixed with polysulfone (PSF) in dimethylformamide DMF solution to investigate their impact on the performance and properties of the support layer and resultant TFC-RO membranes. Results indicated that the new structure of the modified support layer had significant influences on the developed TFC-RO membranes. Notably, the pristine PSF support exhibited a …

Evolution Mechanism Of Organic Macromolecular Structure During Lignite Pyrolysis, Ying Shi, Yanming Zhu, Zhenjiang You, Wu Li, Yang Wang, Yu Song

Research outputs 2022 to 2026

Understanding the mechanisms governing coal pyrolysis reactions, particularly in relation to the coal macromolecular structure, is crucial for improving energy efficiency and facilitating the transition of coal into a clean energy source. This study employs cutting-edge techniques, such as High-Resolution Transmission Electron Microscopy (HRTEM) and Thermogravimetric Analysis coupled with Fourier Transform Infrared Spectroscopy and Mass Spectrometry (TG–FTIR–MS), to analyze lignite and its residual solid samples subjected to pyrolysis across a range of temperatures from 300 °C to 1100 °C. The variational characteristics of the macromolecular structure during coal pyrolysis are examined. Utilizing molecular dynamics simulations, we analyze the evolution mechanism …

Phthalocyanine-Enabled Technologies For Water Treatment And Disinfection Strategies, Hooralain Bushnaq, Catherine Munro, Sisi Pu, Amir Razmjou, Masoumeh Zargar, Giovanni Palmisano, Srinivas Mettu, Ludovic F. Dumée

Research outputs 2022 to 2026

Water treatment and disinfection are critical factors in ensuring a safe and sustainable water supply. Phthalocyanines (Pcs), a class of versatile and robust organic compounds, have garnered significant attention for their application in various water treatment processes. This review paper offers a groundbreaking investigation of Pc-enabled technologies within the domain of water treatment applications. The core aim of this review is to meticulously analyze the chemical and optical properties of Pcs, elucidate their photosensitization mechanism and establish the crucial connection between their chemical structure and photodynamic efficacy. The various modes of Pcs application in water treatment processes - whether in …

Human Rights Violations Against Legal Immigrants In Minnesota, John Ewu

Walden Dissertations and Doctoral Studies

Despite legal entitlements to protections under the International Bill of Human Rights, legal immigrants in Minnesota face human rights violations, including discrimination, harassment, and denial of essential services. These violations hinder their well-being, social integration, and economic stability, exacerbate existing disparities, and their ability to provide for their families and secure legal representation. The purpose of this study was to provide information that could be used in considering policy reforms to improve the treatment of immigrants in Minnesota. This was achieved by exploring how Mexican, Somali, and Hmong legal immigrants experienced human rights violations in Minnesota as a vulnerable population …

Explainable Ai For Cybersecurity Automation, Intelligence And Trustworthiness In Digital Twin: Methods, Taxonomy, Challenges And Prospects, Iqbal H. Sarker, Helge Janicke, Ahmad Mohsin, Asif Gill, Leandros Maglaras

Research outputs 2022 to 2026

Digital twins (DTs) are an emerging digitalization technology with a huge impact on today's innovations in both industry and research. DTs can significantly enhance our society and quality of life through the virtualization of a real-world physical system, providing greater insights about their operations and assets, as well as enhancing their resilience through real-time monitoring and proactive maintenance. DTs also pose significant security risks, as intellectual property is encoded and more accessible, as well as their continued synchronization to their physical counterparts. The rapid proliferation and dynamism of cyber threats in today's digital environments motivate the development of automated and …

Protocol For The Development And Initial Validation Of The Cog-Impact Tool: A Purpose-Built Unmet Needs Assessment For Cancer-Related Cognitive Impairment, Darren Haywood, Moira O’Connor, Frank D. Baughman, Alexandre Chan, Raymond J. Chan, Evan Dauer, Haryana M. Dhillon, Ashley M. Henneghan, Blake J. Lawrence, Maryam Lustberg, Janette L. Vardy, Susan L. Rossell, Nicolas H. Hart

Research outputs 2022 to 2026

(1) Background: A significant proportion of cancer survivors report experiencing a cognitive ‘fog’ that affects their ability to think coherently and quickly, and reason with clarity. This has been referred to as cancer-related cognitive impairment (CRCI). CRCI has extensive impacts on the daily lives of people living with or beyond cancer, including occupational, social, and psychological functioning. Oncology health professionals report feeling under-resourced to effectively assess the needs of an individual with CRCI and then provide optimal care and referral. (2) Methods: The objective of this project is to develop and provide an initial validation of the first purpose-built unmet …

Cardiomyopathy, An Uncommon Phenotype Of Congenital Disorders Of Glycosylation: Recommendations For Baseline Screening And Follow-Up Evaluation, Rameen Shah, Maria Patino, Abigail M Yesso, Justin H Berger, Kyriakie Sarafoglou, Austin Larson, Christina Lam, Eva Morava, Fernando Scaglia

Faculty, Staff and Students Publications

Introduction:

Congenital disorders of glycosylation (CDG) are a continuously expanding group of monogenic disorders that disrupt glycoprotein and glycolipid biosynthesis, leading to multi-systemic manifestations. These disorders are categorized into various groups depending on which part of the glycosylation process is impaired. The cardiac manifestations in CDG can significantly differ, not only across different types but also among individuals with the same genetic cause of CDG. Cardiomyopathy is an important phenotype in CDG. The clinical manifestations and progression of cardiomyopathy in CDG patients have not been well characterized. This study aims to delineate common patterns of cardiomyopathy across a range of …

Parkinson’S Disease Variant Detection And Disclosure: Pd Generation, A North American Study, Jeanine Schulze, Tatiana Foroud, Anne Hall, Karen S Marder, Ignacio F Mata, Niccolò E Mencacci, Martha A Nance, Michael A Schwarzschild, Tanya Simuni, Susan Bressman, Anne-Marie Wills, Hubert H Fernandez, Irene Litvan, Kelly E Lyons, Holly A Shill, Carlos Singer, Thomas F Tropea, Nora Vanegas Arroyave, Janfreisy Carbonell, Rossy Cruz Vicioso, Linn Katus, Joseph F Quinn, Priscila D Hodges, Yan Meng, Samuel P Strom, Cornelis Blauwendraat, Katja Lohmann, Cynthia Casaceli, Shilpa C Rao, Kamalini Ghosh Galvelis, Anna Naito, James C Beck, Roy N Alcalay

Faculty, Staff and Students Publications

Variants in seven genes (LRRK2, GBA1, PRKN, SNCA, PINK1, PARK7 and VPS35) have been formally adjudicated as causal contributors to Parkinson's disease; however, individuals with Parkinson's disease are often unaware of their genetic status since clinical testing is infrequently offered. As a result, genetic information is not incorporated into clinical care, and variant-targeted precision medicine trials struggle to enrol people with Parkinson's disease. Understanding the yield of genetic testing using an established gene panel in a large, geographically diverse North American population would help patients, clinicians, clinical researchers, laboratories and insurers better understand the importance of genetics in approaching Parkinson's …

Geospatial Demand For Approved Cleft Care In The United States, Heather R Burns, Amjed Abu-Ghname, Larry H Hollier

Faculty, Staff and Students Publications

BACKGROUND: Geographic information systems are powerful tools for characterizing the geospatial factors influencing access to care. As patients with cleft lip and/or palate (CL/P) require long-term care, with numerous operations and therapies, access to timely, quality care is extremely important. This study uses population level analysis and geographic information systems to identify United States counties with limited access to American Cleft Palate Association-approved cleft teams.

METHODS: Natality data were queried from the National Vital Statistics System. Population and geographic data were obtained from the US Census Bureau. The Social Vulnerability Index (SVI) was utilized to account for social inequality. Total …

Asynchronous Online Training Increased Knowledge, Confidence, And Intent To Screen And Treat Substance Use Disorders Among Primary Care Clinicians Practicing In Texas, Kylie Schaper, Larissa Grigoryan, Sandra Gonzalez, Alicia Kowalchuk

Faculty, Staff and Students Publications

Introduction: Despite increasing prevalence of substance use disorders (SUD), few patients are diagnosed and treated in primary care settings. This study evaluated changes in knowledge, confidence, and intention to implement screening and brief intervention (SBI) and SUD treatment after clinicians participated in an asynchronous online education course.

Methods: A self-selected sample of primary care clinicians in Texas participated in online SBI and SUD education March 2021-July 2023. Baseline and post-training surveys evaluated changes in knowledge, confidence, and intent to implement SBI and SUD treatment. Changes were compared using paired t-tests. Multivariable linear regression examined factors potentially associated with confidence and …

A Community Health Worker Led Diabetes Self-Management Education Program: Reducing Patient And System Burden, Michael E Bowen, Carolyn Smith-Morris, Elizabeth M Vaughan

Faculty, Staff and Students Publications

Aims: Conduct a secondary analysis of the TIME (Telehealth-supported, Integrated Community Health Workers (CHWs), Medication access, diabetes Education) made simple trial (SIMPLE) to evaluate healthcare utilization and explore variables that may have influenced HbA1c.

Methods: Participants (N = 134 [67/group]) were low-income, uninsured Hispanics with or at risk for type 2 diabetes mellitus. We included in-person and telehealth clinician visits, other visits, missed visits, orders placed, and guideline-adherence (e.g., vaccinations, quarterly HbA1c for uncontrolled diabetes). Using multivariable models, we explored for associations between HbA1c changes and these measures.

Results: The control arm had higher missed visits rates (intervention: 45 %; …

Trajectory Of C-Reactive Protein And Incident Heart Failure In Black Adults: The Jackson Heart Study, Muhammad Shahzeb Khan, Daisuke Kamimura, Rodney K Kipchumba, Ambarish Pandey, Donald Clark, Robert J Mentz, Ervin R Fox, Jarett D Berry, R Brandon Stacey, Amil Shah, Adolfo Correa, Salim S Virani, Javed Butler, Michael E Hall

Faculty, Staff and Students Publications

Background: Increased hsCRP (high-sensitivity C-reactive protein), a marker of inflammation, is associated with incident cardiovascular events. We aim to determine whether the baseline or trajectory of hsCRP levels over time predicts incident heart failure (HF) hospitalization.

Methods: JHS (Jackson Heart Study) participants' (n=3920 Black adults) hsCRP levels were measured over 3 visits (from 2000 to 2013). We assessed the association of hsCRP at baseline (visit 1) with incident HF hospitalization using Cox proportional hazards models. Furthermore, we assessed the association of the trajectory of hsCRP over repeated measurements (visits 1-3) with incident HF using joint models. Hazard ratios are reflective …

Frontiers In Congenital Disorders Of Glycosylation Consortium, A Cross-Sectional Study Report At Year 5 Of 280 Individuals In The Natural History Cohort, Austin Larson, Kyriakie Sarafoglou, Hans C Andersson, Evgenia Sklirou, Queenie K G Tan, Rodrigo T Starosta, Mustafa Sadek, Lynne Wolfe, Seishu Horikoshi, May Ali, Rita Barone, Teresa Campbell, Irene J Chang, Kiaira Coles, Edward Cook, Erik A Eklund, Nicole M Engelhardt, Mary Freeman, Jennifer Friedman, Debbie Y T Fu, Grace Botzo, Brandy Rawls, Christien Hernandez, Christin Johnsen, Kierstin Keller, Sara Kramer, Bryce Kuschel, Angela Leshinski, Ivan Martinez-Duncker, Gina L Mazza, Saadet Mercimek-Andrews, Bradley S Miller, Karthik Muthusamy, Juanita Neira, Marc C Patterson, Natalie Pogorelc, Lex N Powers, Elizabeth Ramey, Michaela Reinhart, Audrey Squire, Jenny Thies, Jerry Vockley, Hayden Vreugdenhil, Peter Witters, Mehdi Youbi, Aziza Zeighami, Roni Zemet, Andrew C Edmondson, Eva Morava

Faculty, Staff and Students Publications

Objective: Our report describes clinical, genetic, and biochemical features of participants with a molecularly confirmed congenital disorder of glycosylation (CDG) enrolled in the Frontiers in Congenital Disorders of Glycosylation (FCDGC) Natural History cohort at year 5 of the study.

Methods: We enrolled individuals with a known or suspected CDG into the FCDGC Natural History Study, a multicenter prospective and retrospective natural history study of all genetic causes of CDG. We conducted a cross-sectional analysis of baseline study visit data from participants with confirmed CDG who were consented into the FCDGC Natural History Study (5U54NS115198) from October 2019 to November 2023. …

Epigenetic Disease Markers In Primary Sclerosing Cholangitis And Primary Biliary Cholangitis-Methylomics Of Cholestatic Liver Disease, Erik M Schlicht, Jackie K Bianchi, Jason M Vollenweider, Hong Ye, Nicholas F Larusso, Gregory J Gores, Zhifu Sun, Konstantinos N Lazaridis

Faculty, Staff and Students Publications

Background: The epigenome, the set of modifications to DNA and associated molecules that control gene expression, cellular identity, and function, plays a major role in mediating cellular responses to outside factors. Thus, evaluation of the epigenetic state can provide insights into cellular adaptions occurring over the course of disease.

Methods: We performed epigenome-wide association studies of primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) using the Illumina MethylationEPIC Bead Chip.

Results: We found evidence of increased epigenetic age acceleration and differences in predicted immune cell composition in patients with PSC and PBC. Epigenetic profiles demonstrated differences in predicted protein …

Patterns Of Social Needs Predict Quality-Of-Life And Healthcare Utilization Outcomes In Patients From A Large Hospital System, Jason B Liu, Allison S Bryant, Peter M Meyers, David W Bates, Nadine J Mccleary, Andrea L Pusic, Maria O Edelen

Faculty, Staff and Students Publications

Background: Unmet social needs (SNs) often coexist in distinct patterns within specific population subgroups, yet these patterns are understudied.

Objective: To identify patterns of social needs (PSNs) and characterize their associations with health-related quality-of-life (HRQoL) and healthcare utilization (HCU).

Design: Observational study using data on SNs screening, HRQoL (i.e., low mental and physical health), and 90-day HCU (i.e., emergency visits and hospital admission). Among patients with any SNs, latent class analysis was conducted to identify unique PSNs. For all patients and by race and age subgroups, compared with no SNs, we calculated the risks of poor HRQoL and time to …

A Content Analysis Of Self-Report Child Anxiety Measures, Sophie C Schneider, Eric A Storch, Andrew G Guzick

Faculty, Staff and Students Publications

A clear understanding of the item content of psychological assessments is critical but often overlooked. This study describes the content overlap of seven commonly used and psychometrically validated measures of anxiety among children and adolescents. Symptom codes were created for all items across measures and items were sorted by these codes, which all fell into specific symptom categories. We conducted two analyses of all items: a "bottom-up" content categorization approach, which used symptom categories that were developed during this study, and a "top-down" DSM-5 categorization which mapped items onto symptoms of anxiety disorders in the DSM-5. Findings reveal a weak …

Ai-Driven Deep Learning Techniques In Protein Structure Prediction, Lingtao Chen, Qiaomu Li, Kazi Fahim Ahmad Nasif, Ying Xie, Bobin Deng, Shuteng Niu, Seyedamin Pouriyeh, Zhiyu Dai, Jiawei Chen, Chloe Yixin Xie

2020-Current year OA Pubs

Protein structure prediction is important for understanding their function and behavior. This review study presents a comprehensive review of the computational models used in predicting protein structure. It covers the progression from established protein modeling to state-of-the-art artificial intelligence (AI) frameworks. The paper will start with a brief introduction to protein structures, protein modeling, and AI. The section on established protein modeling will discuss homology modeling, ab initio modeling, and threading. The next section is deep learning-based models. It introduces some state-of-the-art AI models, such as AlphaFold (AlphaFold, AlphaFold2, AlphaFold3), RoseTTAFold, ProteinBERT, etc. This section also discusses how AI techniques …

Potential Us Health Care Savings Based On Clinician Views Of Feasible Site-Of-Care Shifts, Nikhil R Sahni, Crosbie Marine, David M Cutler, Laura N Medford-Davis, Melvin Mezue, Omar Kattan, Ed Levine, Karen E Joynt Maddox

2020-Current year OA Pubs

IMPORTANCE: Shifting care to alternative sites when clinically appropriate may be associated with reduced US health care spending, improved access, and, in some cases, improved care outcomes.

OBJECTIVE: To fill 2 main gaps in the current literature on site-of-care shifts: (1) understanding the clinician perspective on appropriateness of alternative care sites, given the central role they play in referrals and patient trust and (2) considering all potential sites where care could shift and calculating net savings potential.

DESIGN, SETTING, AND PARTICIPANTS: In this survey study, physicians (MDs and DOs), nurse practitioners, physician assistants, nurse anesthetists, radiology and imaging technicians, and …

Posttraumatic Stress Disorder And Type 2 Diabetes Outcomes In Veterans, Jeffrey F Scherrer, Joanne Salas, Wenjin Wang, Kenneth E Freedland, Patrick J Lustman, Paula P Schnurr, Beth E Cohen, Allan S Jaffe, Matthew J Friedman

2020-Current year OA Pubs

IMPORTANCE: Posttraumatic stress disorder (PTSD) symptom reduction is linked with lower risk of incident type 2 diabetes (T2D), but little is known about the association between PTSD and comorbid T2D outcomes. Whether PTSD is a modifiable risk factor for adverse T2D outcomes is unknown.

OBJECTIVE: To determine whether patients with PTSD who improved and no longer met diagnostic criteria for PTSD had a lower risk of adverse T2D outcomes compared with patients with persistent PTSD.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used deidentified data from US Veterans Health Administration (VHA) historical medical records (from October 1, 2011, to …

Age-Related Dysregulation Of The Retinal Transcriptome In African Turquoise Killifish, Steven Bergmans, Nicole C L Noel, Luca Masin, Ellen G Harding, Aleksandra M Krzywańska, Julie D De Schutter, Rajagopal Ayana, Chi-Kuo Hu, Lut Arckens, Philip A Ruzycki, Ryan B Macdonald, Brian S Clark, Lieve Moons

2020-Current year OA Pubs

Age-related vision loss caused by retinal neurodegenerative pathologies is becoming more prevalent in our ageing society. To understand the physiological and molecular impact of ageing on retinal homeostasis, we used the short-lived African turquoise killifish, a model known to naturally develop central nervous system (CNS) ageing hallmarks and vision loss. Bulk and single-cell RNA-sequencing (scRNAseq) of three age groups (6-, 12-, and 18-week-old) identified transcriptional ageing fingerprints in the killifish retina, unveiling pathways also identified in the aged brain, including oxidative stress, gliosis, and inflammageing. These findings were comparable to observations in the ageing mouse retina. Additionally, transcriptional changes in …

Geometric Accuracy Of Low-Dose Ct Scans For Use In Shoulder Musculoskeletal Research Applications, Rebekah L Lawrence, Lydia Nicholson, Erin C S Lee, Kelby Napier, Benjamin Zmistowski, Michael J Rainbow

2020-Current year OA Pubs

Computed tomography (CT) imaging is frequently employed in a variety of musculoskeletal research applications. Although research studies often use imaging protocols developed for clinical applications, lower dose protocols are likely possible when the goal is to reconstruct 3D bone models. Our purpose was to describe the dose-accuracy trade-off between incrementally lower-dose CT scans and the geometric reconstruction accuracy of the humerus, scapula, and clavicle. Six shoulder specimens were acquired and scanned using 5 helical CT protocols: 1) 120 kVp, 450 mA (full-dose); 2) 120 kVp, 120 mA; 3) 120 kVp, 100 mA; 4) 100 kVp, 100 mA; 5) 80 kVp, …

Sex-Dependent Differences In Vulnerability To Early Risk Factors For Posttraumatic Stress Disorder: Results From The Aurora Study, Stephanie Haering, Stacey L House, Et Al.

2020-Current year OA Pubs

BACKGROUND: Knowledge of sex differences in risk factors for posttraumatic stress disorder (PTSD) can contribute to the development of refined preventive interventions. Therefore, the aim of this study was to examine if women and men differ in their vulnerability to risk factors for PTSD.

METHODS: As part of the longitudinal AURORA study, 2924 patients seeking emergency department (ED) treatment in the acute aftermath of trauma provided self-report assessments of pre- peri- and post-traumatic risk factors, as well as 3-month PTSD severity. We systematically examined sex-dependent effects of 16 risk factors that have previously been hypothesized to show different associations with …

2023 American College Of Rheumatology (Acr)/American College Of Chest Physicians (Chest) Guideline For The Screening And Monitoring Of Interstitial Lung Disease In People With Systemic Autoimmune Rheumatic Diseases, Jonathan H Chung, Sonye K Danoff, Michael D George, Dinesh Khanna, Gordon Guyatt, Reza D Mirza, Rohit Aggarwal, Aberdeen Allen, Shervin Assassi, Lenore Buckley, Hassan A Chami, Douglas S Corwin, Paul F Dellaripa, Robyn T Domsic, Tracy J Doyle, Catherine Marie Falardeau, Tracy M Frech, Fiona K Gibbons, Monique Hinchcliff, Cheilonda Johnson, Jeffrey P Kanne, John S Kim, Sian Yik Lim, Scott Matson, Zsuzsanna H Mcmahan, Samantha J Merck, Kiana Nesbitt, Mary Beth Scholand, Lee Shapiro, Christine D Sharkey, Ross Summer, John Varga, Anil Warrier, Sandeep K Agarwal, Danielle Antin-Ozerkis, Bradford Bemiss, Vaidehi Chowdhary, Jane E Dematte D'Amico, Robert Hallowell, Alicia M Hinze, Patil A Injean, Nikhil Jiwrajka, Elena K Joerns, Joyce S Lee, Ashima Makol, Gregory C Mcdermott, Jake G Natalini, Justin M Oldham, Didem Saygin, Kimberly Showalter Lakin, Namrata Singh, Joshua J Solomon, Jeffrey A Sparks, Marat Turgunbaev, Samera Vaseer, Amy Turner, Stacey Uhl, Ilya Ivlev

Faculty, Staff and Students Publications

Objective: We provide evidence-based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring for ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, and Sjögren disease.

Methods: We developed clinically relevant population, intervention, comparator, and outcomes questions related to screening and monitoring for ILD in patients with SARDs. A systematic literature review was performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A Voting Panel of interdisciplinary clinician experts and patients achieved consensus on the direction and …

2023 American College Of Rheumatology (Acr)/American College Of Chest Physicians (Chest) Guideline For The Screening And Monitoring Of Interstitial Lung Disease In People With Systemic Autoimmune Rheumatic Diseases, Jonathan H Chung, Sonye K Danoff, Michael D George, Dinesh Khanna, Gordon Guyatt, Reza D Mirza, Rohit Aggarwal, Aberdeen Allen, Shervin Assassi, Lenore Buckley, Hassan A Chami, Douglas S Corwin, Paul F Dellaripa, Robyn T Domsic, Tracy J Doyle, Catherine Marie Falardeau, Tracy M Frech, Fiona K Gibbons, Monique Hinchcliff, Cheilonda Johnson, Jeffrey P Kanne, John S Kim, Sian Yik Lim, Scott Matson, Zsuzsanna H Mcmahan, Samantha J Merck, Kiana Nesbitt, Mary Beth Scholand, Lee Shapiro, Christine D Sharkey, Ross Summer, John Varga, Anil Warrier, Sandeep K Agarwal, Danielle Antin-Ozerkis, Bradford Bemiss, Vaidehi Chowdhary, Jane E Dematte D'Amico, Robert Hallowell, Alicia M Hinze, Patil A Injean, Nikhil Jiwrajka, Elena K Joerns, Joyce S Lee, Ashima Makol, Gregory C Mcdermott, Jake G Natalini, Justin M Oldham, Didem Saygin, Kimberly Showalter Lakin, Namrata Singh, Joshua J Solomon, Jeffrey A Sparks, Marat Turgunbaev, Samera Vaseer, Amy Turner, Stacey Uhl, Ilya Ivlev

Faculty, Staff and Students Publications

Objective: We provide evidence-based recommendations regarding screening for interstitial lung disease (ILD) and the monitoring for ILD progression in people with systemic autoimmune rheumatic diseases (SARDs), specifically rheumatoid arthritis, systemic sclerosis, idiopathic inflammatory myopathies, mixed connective tissue disease, and Sjögren disease.

Methods: We developed clinically relevant population, intervention, comparator, and outcomes questions related to screening and monitoring for ILD in patients with SARDs. A systematic literature review was performed, and the available evidence was rated using the Grading of Recommendations, Assessment, Development, and Evaluation methodology. A Voting Panel of interdisciplinary clinician experts and patients achieved consensus on the direction and …

Muscle Mitochondrial Function Is Impaired In Adults With Type 1 Diabetes, Judith G Regensteiner, Jane E B Reusch, Kalie L Tommerdahl, John Rice, Leslie A Knaub, Cynthia M F Monaco, Thomas J Hawke, Christopher G R Perry, Melanie G Cree, Irene E Schauer

Faculty, Staff and Students Publications

Aims: Type 1 diabetes has been associated with mitochondrial dysfunction. However, the mechanism of this dysfunction in adults remains unclear.

Methods: A secondary analysis was conducted using data from several clinical trials measuring in-vivo and ex-vivo mitochondrial function in adults with type 1 diabetes (n = 34, age 38.8 ± 14.6 years) and similarly aged controls (n = 59, age 44.6 ± 13.9 years). In-vivo mitochondrial function was assessed before, during, and after isometric exercise with 31phosphorous magnetic resonance spectroscopy. High resolution respirometry of vastus lateralis muscle tissue was used to assess ex-vivo measures.

Results: In-vivo data showed higher rates …

How Anthropocentrism Shaped Florida, Olivia Benson

Harriet L Wilkes Honors College Theses 2020 - Present

Anthropocentrism, the belief that humankind is central to existence and has priority over all other living beings and systems, is embedded in Western philosophy and motivates environmental degradation. The history of Florida provides some of the most egregious examples, compiled with instances of large-scale transformation and destruction for the sake of tourist, residential, commercial, and industrial developments. Florida’s rapid development and natural resource use in the twentieth century changed its unique landscape by using ruinous methods to reclaim land and synthesize a paradise for humans alone. The loss of over half of the Everglades—the unique wetland system with incredible biodiversity—is …

Variation In Zero Plane Displacement And Roughness Length For Momentum Revisited, Ashvath Singh Kunadi, Richard P. Silberstein, Sally E. Thompson

Research outputs 2022 to 2026

Zero plane displacement height (d0) and momentum roughness length (z0m), describe the aerodynamic characteristics of a vegetated surface. Usually, d0 and z0m are assumed to be constant functions of the physical characteristics of the surface. Prior evidence collected from the literature and our examination of flux tower data show that d0 and z0m vary in time at sites with tree and shrub canopies, but not grasslands. The conventional explanations of these variations are based on linear functions of wind velocity and friction velocity, with little theoretical basis. This study explains the variation in aerodynamic parameters by matching four analytical canopy …

Assessing Sarcopenia In Advanced-Stage Ovarian Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Case Series, Christelle Schofield, Dennis R. Taaffe, Robert U. Newton, Daniel A. Galvão, Paul A. Cohen, Jin Soo Kim, Tarek Meniawy, Carolyn Peddle-Mcintyre

Research outputs 2022 to 2026

Objectives: In ovarian and other cancers, low muscle mass and density are associated with poorer clinical outcomes. However, screening for cancer-related sarcopenia (typically defined as low muscle mass) is not routinely conducted. The European Working Group on Sarcopenia in Older People (EWGSOP) recommends an algorithm for sarcopenia screening and diagnosis in clinical settings, with sarcopenia based on muscle strength and mass, and severity on physical performance. We explored the application of the EWGSOP2 algorithm to assess sarcopenia in six ovarian cancer patients receiving neoadjuvant chemotherapy. Methods: We assessed sarcopenia risk with the SARC-F screening questionnaire (at risk ≥4 points), muscle …

A Gendered Lens On Mediation And Market Governance: Experiences Of Women Market Vendors In Papua New Guinea, Wilma Langa, Jackie Kauli, Verena Thomas

Research outputs 2022 to 2026

The majority of market vendors at urban informal markets in Papua New Guinea are women. They face vulnerabilities related to safety, security and infrastructural support. They operate within male-dominated mediation structures where women’s contributions to mediation and market governance are often invisible. However, in this article, we demonstrate how women market vendors contribute to the social aspect of market governance, particularly addressing issues of law and order within Awagasi market. Through the efforts of women vendors in mediation and conflict management, safety in the market and normal operation of the informal market have improved. The study involved 18 women market …