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Dark Critiques Of Victorian Identity: The Picture Of Dorian Gray And The Turn Of The Screw, Shania T. Inshan Apr 2026

Dark Critiques Of Victorian Identity: The Picture Of Dorian Gray And The Turn Of The Screw, Shania T. Inshan

Student Theses and Dissertations

My thesis highlights the relationship between beauty, art, and identity through a gothic lens using The Picture of Dorian Gray by Oscar Wilde and The Turn of the Screw by Henry James. I argue that beauty and art fail to sustain innocence and life itself through an exploration of the progressively corrupt identities of the central characters in each novel. Additionally, I find that both authors challenge common conventions of art, beauty, adolescence, and gender of 19th-century British society and expand the list of factors that comprise identity. James’s narrator diverges from the model of the ideal governess and Wilde’s …


Scenarioxp: A Complete Scenario-Based Testing Framework For The Exploration And Exploitation Of Autonomous Vehicle Validation Scenarios, Quentin Goss Apr 2026

Scenarioxp: A Complete Scenario-Based Testing Framework For The Exploration And Exploitation Of Autonomous Vehicle Validation Scenarios, Quentin Goss

Doctoral Dissertations and Master's Theses

Today is an age of exciting emerging technology where cutting-edge research in autonomous vehicles (AVs) reduces the active human participation in driving and extends awareness beyond human limitations of perception and reaction, improving driving safety and quality of the user experience as a result. The ever-increasing complexity of these autonomous systems poses many challenges towards the validation and verification (V\&V) of these complex systems under time and resource constraints, as the use of artificial intelligence and also the intricacy of the operating environment means that these systems are also black-box and non-deterministic. Scenario-based V\&V testing of such systems, which involves …


Insect Inspired Behavioral Strategies For Improving Multi-Agent System Resilience In The Presence Of Contagious Faults, James E. Hand Apr 2026

Insect Inspired Behavioral Strategies For Improving Multi-Agent System Resilience In The Presence Of Contagious Faults, James E. Hand

Doctoral Dissertations and Master's Theses

As Multi-Agent Systems (MASs) become increasingly involved in every aspect of everyday life the need to maintain reliability and resilience within these systems grows. However, in equal measure bad actors wishing to maliciously control or alter these systems are growing in both scale and capability. Thus, there is a present need for control schemes and agent behaviors that provide security against these threats while also avoiding large degradation in system performance as a tradeoff. Current research has covered a wide breadth of avenues and strategies that provide measurable resilience to faulted agents. However, these strategies often require group consensus, specialized …


Effect Of Nozzle Pressure Ratio On Thrust And Flow Behavior In A Supersonic De Laval Nozzle, Esha Jain Apr 2026

Effect Of Nozzle Pressure Ratio On Thrust And Flow Behavior In A Supersonic De Laval Nozzle, Esha Jain

Doctoral Dissertations and Master's Theses

Supersonic nozzles operate across a range of flow regimes. While an ideally expanded condition yields optimal thrust, practical propulsion systems rarely operate at this design point due to variations in altitude and engine operating conditions. As a result, nozzles frequently operate in off-design conditions. In overexpanded regime, where the exit pressure is lower than the ambient pressure, shock-induced separation may occur within the divergent section of the nozzle, potentially degrading nozzle performance. Understanding the aerodynamic behavior of nozzles operating under off-design conditions is therefore important for improving propulsion system performance and stability. In particular, direct thrust measurements provide a key …


Study Of Output And Behavior Of Llms Using Confidence Framing In Prompt Engineering, Micah Parrilla Apr 2026

Study Of Output And Behavior Of Llms Using Confidence Framing In Prompt Engineering, Micah Parrilla

Doctoral Dissertations and Master's Theses

While prompt engineering is pivotal for shaping Large Language Model (LLM) outputs, the impact of confidence framing on behavioral calibration remains underexplored. This study investigates the ways in which psychological framing, utilizing techniques such as capability praise, role amplification, and doubt induction, affects linguistic tone, objective accuracy, and internal calibration. A 1,080-trial experimental matrix evaluated six diverse models across factual, logical, coding, and cyber security domains. Analysis using the Kruskal-Wallis H-test revealed highly significant behavioral shifts across all measured dimensions, providing conclusive evidence that the applied frames exert a substantial influence on model performance.

The findings identify a distinct cognitive …


Msw Portfolio: Grounded In Perpetuity And Well-Being Of The Future Generation, Silver A. Little Eagle Apr 2026

Msw Portfolio: Grounded In Perpetuity And Well-Being Of The Future Generation, Silver A. Little Eagle

Graduate Student Portfolios, Professional Papers, and Capstone Projects

The MSW Portfolio, Grounded in Perpetuity and Well-being of the Future Generation, by Silver Little Eagle (Northern Cheyenne), is an Advanced Integral Practice portfolio submitted in partial fulfillment of the Master of Social Work degree at the University of Montana. Integrating the core competencies outlined by the University of Montana School of Social Work and the Council on Social Work Education, this portfolio draws on the author's identity as an Indigenous social work practitioner, as a citizen of the Northern Cheyenne Tribe, as a Tsé-tsėhéstaestse naa Só'taeo'o woman, as an eldest sister raised by her grandmothers, and as a Youth …


Additive Manufacturing Of Ti-Ni Based Ternary Shape Memory Alloys, Yitao Chen, Frank Liou Apr 2026

Additive Manufacturing Of Ti-Ni Based Ternary Shape Memory Alloys, Yitao Chen, Frank Liou

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Metal additive manufacturing has become a powerful tool to develop customized metal alloys and to discover more advanced properties for novel extended applications. Ti-Ni based shape memory alloy is a group of intriguing smart functional materials, and adding a small amount of a third element can promote and induce more attractive functions. Due to the difficulty in traditional processing and the unique feature of material flexibility of in-situ alloying in additive manufacturing processes, not only Ti-Ni binary shape memory alloys but also Ti-Ni-X ternary shape memory alloys can be developed, manufactured, and investigated in-depth by additive manufacturing. This paper provides …


Dissent By Design: Graphic Communication And The Continuity Of Resistance As A Civic Practice In The United States, Ryan "Rain" Milligan Apr 2026

Dissent By Design: Graphic Communication And The Continuity Of Resistance As A Civic Practice In The United States, Ryan "Rain" Milligan

Theses

Graphic communication has played a role in shaping civic life in the United States throughout much of its history, influencing how individuals recognize injustice, understand systems of power, and participate in collective action. Typically associated with moments of protest or political upheaval, printed materials such as pamphlets, broadsides, newspapers, and posters have also functioned as everyday tools that structure public engagement. This project examines these materials through the framework of agitation, education, and organization, considering how graphic communication operates across different historical contexts to provoke recognition, make complex ideas accessible, and coordinate collective effort. Drawing from a range of historical …


In-Context Retrieval For Molecules And Chemical Synthesis Pathways, Abhisek Dey Apr 2026

In-Context Retrieval For Molecules And Chemical Synthesis Pathways, Abhisek Dey

Theses

Contrastive learning methods require well-defined positive pairs, limiting their applicability to domains where complete, high-fidelity pairings are available. In practice, large-scale scientific corpora --including patents, publications, and web-scale data -- contain vast quantities of contextually relevant but incompletely paired samples that are discarded under standard training paradigms. In this work, we demonstrate that hard negative mining can be leveraged to construct pseudo-positive supervision signals from unpaired or partially paired data, enabling contrastive learning to exploit the full breadth of available corpora without sacrificing representational quality. Using a large-scale chemical drug patent corpus as a testbed, we train a cross-modal contrastive …


The Best Practices For Prefabrication Of Industrial Buildings, Derek Gines Apr 2026

The Best Practices For Prefabrication Of Industrial Buildings, Derek Gines

Theses

Prefabrication has demonstrated measurable and repeatable advantages in productivity, cost certainty, and environmental performance, yet its adoption within industrial building typologies remains largely inconsistent. Existing research largely evaluates prefabrication through downstream performance outcomes, while offering limited insight into the upstream design and organizational decisions that enable or undermine its reliability. This thesis reframes prefabrication as a design‑led methodology rather than a construction optimization, arguing that successful hybrid prefabrication is determined primarily by early decision timing, governance structures, and the control of spatial and logistical interfaces. This study adopts a qualitative design‑research approach that combines comparative case study analysis with expert …


Reducing Computed Tomography Delay In A High-Volume Emergency Department, Sarah Ouedraogo Apr 2026

Reducing Computed Tomography Delay In A High-Volume Emergency Department, Sarah Ouedraogo

All Doctor of Nursing Practice (DNP) Scholarly Projects

Problem:

Delays in computed tomography (CT) imaging contribute to prolonged emergency department (ED) length of stay and delayed clinical decision-making. At the project site, baseline data demonstrated an average ASAP CT order-to-scan time of approximately 116 minutes for non-critical ED patients, with CT readiness compliance rates of 0%. Gap analysis identified inconsistent patient preparation and fragmented communication between ED nursing and radiology as key contributors to avoidable delays. PICOT question: In non-emergent emergency department (ED) patients (P), how does the use of a CT readiness checklist by ED nurses (I), compared with no standardized readiness checklist (C), affect patient readiness …


Computational Analysis Of Immigration Discourse And Political Polarization: Evidence From U.S. Political Podcasts During The 2024 Presidential Election, Reishiro Kawakami , ‘26 Apr 2026

Computational Analysis Of Immigration Discourse And Political Polarization: Evidence From U.S. Political Podcasts During The 2024 Presidential Election, Reishiro Kawakami , ‘26

Senior Theses, Projects, and Awards

This study examines how immigration is discussed across the U.S. political podcast ecosystem during the 2024 presidential election cycle, with a focus on differences across the political spectrum. While prior research on immigration attitudes has relied heavily on survey data, this study shifts attention to naturally occurring political communication by analyzing large-scale podcast transcripts. Drawing on a novel dataset of over 48,500 episodes (approximately 40,000 hours of audio) from the top 100 political podcasts ranked on Election Day, this paper combines keyword search, topic modeling, and sentiment analysis to investigate both the thematic structure and emotional tone of immigration discourse. …


Soil Erosion In The Crum Woods: Testing And Mitigation, Andrew Narain , ‘26, Sabina Karabin , ‘26 Apr 2026

Soil Erosion In The Crum Woods: Testing And Mitigation, Andrew Narain , ‘26, Sabina Karabin , ‘26

Senior Theses, Projects, and Awards

This project aimed to determine the optimal erosion mitigation method for a specific site in the Crum Woods in Swarthmore, Pennsylvania. Inexpensive and bench-scale laboratory testing protocol was designed to measure the efficiency of retaining walls and of planting native grasses against a baseline, using rainfall simulations over a smaller version of the site slope. Erosion mitigation was measured through increased water infiltration through soil and decreased sediment runoff. It was found that the retaining wall increased infiltration of water into the soil from 2% (control) to 14.7% (retaining wall), but was outperformed by the plant infiltration of 27.5%. While …


Sex, Gender, And The Blogosphere: Looking Back At The Feminist Law Professors Blog, 2006-2024, Bridget J. Crawford Apr 2026

Sex, Gender, And The Blogosphere: Looking Back At The Feminist Law Professors Blog, 2006-2024, Bridget J. Crawford

Elisabeth Haub School of Law Faculty Publications

The Feminist Law Professors blog began in 2006 as a modest effort to make feminist legal scholars more visible to one another and to the broader world. What emerged from this effort was a dynamic, collectively imagined space that bore witness to generational shifts in feminist legal thought, the rise and fall of blogging culture, and the enduring challenges of feminist community-building. This Essay reflects on the origins, evolution, and legacies of the Feminist Law Professors blog, situating it within its legal, cultural, and technological moments. It also offers my reflections--as one of two blog editors--on the risks and rewards …


A Comparative Analysis Of State Legislation Prohibiting Gender-Affirming Care For Missouri Minors: A Policy Review, Hayley Lange, Benjamin Grin, Kaitlyn Crosby Apr 2026

A Comparative Analysis Of State Legislation Prohibiting Gender-Affirming Care For Missouri Minors: A Policy Review, Hayley Lange, Benjamin Grin, Kaitlyn Crosby

Missouri Policy Journal

The Save Adolescents from Experimentation (SAFE) Act is a law enacted in August 2023 that banned gender-affirming medical care for individuals under 18 in Missouri. It states that any medical provider who provides medical gender-affirming care to a minor will have their professional medical license revoked. The purpose of this policy review is to evaluate and compare the content of the Missouri SAFE Act with similar legislation enacted in other states to provide an evaluative model.        

This policy assessment used a modified assessment tool that was developed by the Centers for Disease Control and Prevention (CDC). The assessment included a …


An Analysis Of Global And Regional Human Rights Standards On Gender-Based Violence, Tamar Ezer, Denisse R. Cordova Montes Apr 2026

An Analysis Of Global And Regional Human Rights Standards On Gender-Based Violence, Tamar Ezer, Denisse R. Cordova Montes

Articles

No abstract provided.


Leadership Communication Newsletter Spring 2026, Leadership Communication-Winona State University, Andrew Peine, Russell Zwiers, Miah Graczyk, Dorothy Moore, Robert Whisler Apr 2026

Leadership Communication Newsletter Spring 2026, Leadership Communication-Winona State University, Andrew Peine, Russell Zwiers, Miah Graczyk, Dorothy Moore, Robert Whisler

Leadership Education Newsletters

This is the newsletter created by the graduate students in the Leadership Communication 615 spring 2026 course.


April 2026, Office Of Research Apr 2026

April 2026, Office Of Research

Research Update

No abstract provided.


The Citizen And The Smart City: A Global Comparison Of Institutional Logics, Tim Bunnell, Zachary Spicer, Byron Miller, Teresa Abbruzzese, Paolo Cardullo, Sangwon Chae, I-Chun Catherine Chang, Greig Charnock, Ming-Kuang Chung, Kwon Heo, Sue-Ching Jou, Andrew Karvonen, Olga Kordas, Kong, Lily, Ramon Ribera-Fumaz, Haeran Shin, Orlando Woods Apr 2026

The Citizen And The Smart City: A Global Comparison Of Institutional Logics, Tim Bunnell, Zachary Spicer, Byron Miller, Teresa Abbruzzese, Paolo Cardullo, Sangwon Chae, I-Chun Catherine Chang, Greig Charnock, Ming-Kuang Chung, Kwon Heo, Sue-Ching Jou, Andrew Karvonen, Olga Kordas, Kong, Lily, Ramon Ribera-Fumaz, Haeran Shin, Orlando Woods

Research Collection College of Integrative Studies

Crucial urbanists’ placement of smart city initiatives in Western Europe or North America mostly on the “low” rungs of participatory ladders or scaffolds does not mean that smart urban development necessarily connotes democracy-eroding neoliberalization everywhere. This article offers a more globally variegated and dynamic understanding of the relationship between citizens and smart cities. We apply an institutional logics framework to the citizen-smart city nexus in seven cities spanning three world regions, considering the interplay of citizen-centric logics with techno-innovation-oriented and bureaucratic/managerial logics. Appreciating contextually specific institutional orders helps to explain why similar initiatives and intentions yield different outcomes across time …


Weather Rescue At Sea: Recovering Historical Weather Observations From 19th Century British Naval Ships, Praveen Teleti, Ed Hawkins, Clive Wilkinson Apr 2026

Weather Rescue At Sea: Recovering Historical Weather Observations From 19th Century British Naval Ships, Praveen Teleti, Ed Hawkins, Clive Wilkinson

Research Collection College of Integrative Studies

Ship logbooks represent a critical source of historical meteorological data, providing valuable observations of barometric pressure, air temperature, sea surface temperature, wind force and direction, and other variables. Substantial quantities of these records are unavailable to climate science as they have not yet been transcribed. We present ‘Weather Rescue at Sea’, a citizen-science project which transcribed millions of weather observations contained in 19th Century UK Royal Navy ship logbooks. We describe the logbook structure and weather observation-taking instructions and discuss significant challenges with the translation of handwritten text into accurate data due to errors arising from ambiguous handwriting, historical terminology, …


Unraveling The Intractable Trilemma In Urban Weather And Climate Modeling, Peiyuan Li, Ashish Sharma, Rao Kotamarthi, Alberto Martilli, Subimal Ghosh, Cristina Negri, Scott Collis, Lee Chapman, Fei Chen, Luis M. A. Bettencourt, Winston T. L. Chow Apr 2026

Unraveling The Intractable Trilemma In Urban Weather And Climate Modeling, Peiyuan Li, Ashish Sharma, Rao Kotamarthi, Alberto Martilli, Subimal Ghosh, Cristina Negri, Scott Collis, Lee Chapman, Fei Chen, Luis M. A. Bettencourt, Winston T. L. Chow

Research Collection College of Integrative Studies

Urban weather and climate modeling is constrained by the highly heterogeneous and dynamic nature of cities. It exhibits a persistent trilemma between spatial granularity, spatiotemporal coverage, and physical interpretability. We articulate this challenge and propose a hybrid framework that integrates physics -based models, urban observations, and machine learning. Framing urban modeling as an integration problem across methods and scales, we provide a structured guide for next -generation, decision -relevant urban climate capabilities.


Konstytucja Gospodarcza Przed Sądem – Analiza Porównawcza Wyroków Sądu Najwyższego W Sprawie Iii Sk 5/17 Oraz Trybunału Sprawiedliwości Ue W Sprawie C-413/14 (Intel Przeciwko Komisji), Piotr Oliński Apr 2026

Konstytucja Gospodarcza Przed Sądem – Analiza Porównawcza Wyroków Sądu Najwyższego W Sprawie Iii Sk 5/17 Oraz Trybunału Sprawiedliwości Ue W Sprawie C-413/14 (Intel Przeciwko Komisji), Piotr Oliński

internetowy Kwartalnik Antymonopolowy i Regulacyjny (internet Quarterly on Antitrust and Regulation)

Zarówno art. 20 Konstytucji RP, jak i art. 3(3) Traktatu o Unii Europejskiej zawiera tę samą zasadę organizacji życia gospodarczego – społeczną gospodarkę rynkową. W poniższym artykule społeczna gospodarka rynkowa traktowana jest jako obowiązująca konstytucja gospodarcza w obu porządkach prawnych. Przez jej pryzmat porównawczo analizowana jest aksjologia wyroku polskiego Sądu Najwyższego w sprawie III SK 5/17 oraz Trybunału Sprawiedliwości UE w sprawie C-413/14. Artykuł poświęcony jest poszukiwaniu odpowiedzi na pytanie o podobieństwo recepcji stojącej za społeczną gospodarką rynkową myśli ordoliberalnej w obu porządkach prawnych.


Online Safety (Relief And Accountability) Bill: Further Experiments In Balancing Rights And Responsibilities, Siyuan Chen, Zavier Yu Wu, Jie Ting Lee Apr 2026

Online Safety (Relief And Accountability) Bill: Further Experiments In Balancing Rights And Responsibilities, Siyuan Chen, Zavier Yu Wu, Jie Ting Lee

Research Collection Yong Pung How School Of Law

Singapore’s latest legislation to address online harms, the Online Safety (Relief and Accountability) Bill, was passed in Parliament in November 2025. The legislation, which takes a complainant-centric approach, provides the Commissioner of Online Safety a broad range of powers so that timely redress can be given for reports of online harms such as image abuse, sexual harassment, doxxing, and stalking. Various torts that impose duties on administrators and platforms have also been created. Legislation of this nature invariably raises issues about whether an appropriate balance between freedom and responsibility has been struck. This Legislative Comment analyses some of the more …


Negotiating At A Distance: The Impact Of Communication Media And Negotiator Traits, Dorcas Quek Anderson, Tra My Ngo Apr 2026

Negotiating At A Distance: The Impact Of Communication Media And Negotiator Traits, Dorcas Quek Anderson, Tra My Ngo

Research Collection Yong Pung How School Of Law

Purpose – Prior research has yet to provide a coherent theoretical framework explaining how communication media hinder or advance negotiation success, and many dated studies are unlikely to be relevant. This study aims to examine the impact of four communication media on negotiation outcomes. It also examines the potential moderating effects of the following negotiator characteristics: conflict management style, personality traits and indirect communication style.Design/methodology/approach – A total of 400 participants formed 200 dyads to negotiate a mixed- motive relational conflict through face-to-face (FTF) interaction, videoconferencing, audio call or synchronous text messaging. Linear mixed regression was used to assess the …


Near-Wall Void Distribution Characterization In Pebble Bed Reactor Using Gamma-Ray Ct And Dem Simulation, Ahmed Jasim, Mauricio Maestri, Abdullah Al Zubaidi, Omar Farid, Muthanna Al-Dahhan Apr 2026

Near-Wall Void Distribution Characterization In Pebble Bed Reactor Using Gamma-Ray Ct And Dem Simulation, Ahmed Jasim, Mauricio Maestri, Abdullah Al Zubaidi, Omar Farid, Muthanna Al-Dahhan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Accurate characterization of void-fraction distributions in pebble-bed reactors (PBRs) is essential for predicting flow, heat transfer, and neutronic behavior. High-fidelity experimental benchmark data for validating such predictions remain scarce, largely due to the challenges of non-invasive measurements. In this study, gamma-ray computed tomography (CT) was employed to measure radial and cross-sectional porosity in a laboratory-scale pebble bed containing 6cm graphite pebbles. A Discrete Element Method (DEM) simulation was implemented and validated against these measurements, then applied to the full-scale geometry of the Xe-100 high-temperature gas-cooled pebble-bed reactor. Analyses included radial and axial void-fraction profiles in the cylindrical section and conical …


Functional Annotation Of Gordonia Phage Minor Tail Proteins Using Alphafold And Structural Homology Searches, Harani Athwale, Mitchell Thenor Apr 2026

Functional Annotation Of Gordonia Phage Minor Tail Proteins Using Alphafold And Structural Homology Searches, Harani Athwale, Mitchell Thenor

Undergraduate Student Symposium

Bacteriophages are viruses that infect bacteria. The basic phage structure consists of a DNA or RNA genome encased in a capsid protein shell. Some may also have a tail, important for attachment and genome delivery into the bacterial host. Recently, the structure of mycobacteriophage Bxb1 was characterized and determined to have 10 minor tail proteins, each assigned a unique function. The genomes of Gordonia rubripertincta phages Fribs8, Genamy16, Alyssamiracle, and NovaSharks were annotated, depicting several minor tai proteins. However, the specific functions were not determined. Therefore, the goal of this research was to assign a specific function to the minor …


Exercise As An Intervention Against Neuroinflammation During Binge Drinking Withdrawal, Shaina Binu, Ellie Wind, Ariana Hernandez, Iliana Uribe, Victoria Pulido-Correa Apr 2026

Exercise As An Intervention Against Neuroinflammation During Binge Drinking Withdrawal, Shaina Binu, Ellie Wind, Ariana Hernandez, Iliana Uribe, Victoria Pulido-Correa

Undergraduate Student Symposium

Binge drinking, a public health concern in the United States, is associated with negative emotional and cognitive effects during alcohol withdrawal. These effects are believed to result from changes in brain regions involved in stress regulation, emotion, and decision-making, including the prefrontal cortex, amygdala, and hippocampus. Alcohol exposure has been shown to increase neuroinflammation in these regions, which may contribute to anxiety-like behaviors and difficulty regulating emotions during withdrawal. In contrast, aerobic exercise is a promising non-pharmacological intervention that has been shown to reduce anxiety and support brain health. This project investigates how exercise can reduce withdrawal-related anxiety-like behaviors, following …


Evaluating Item Discrimination And Gender-Based Differential Item Functioning In Safe Sex Behavior Questionnaire (Ssbq), Prarthana Harikrishnan, Xinlei Zhang, Hannah Scheffer Apr 2026

Evaluating Item Discrimination And Gender-Based Differential Item Functioning In Safe Sex Behavior Questionnaire (Ssbq), Prarthana Harikrishnan, Xinlei Zhang, Hannah Scheffer

Undergraduate Student Symposium

Risky sexual behavior can increase rates of sexually transmitted infections (STIs), posing a danger to the health of young adults. The Safe Sex Behavior Questionnaire (SSBQ; Dilorio et al., 1992) is a widely used measure to assess risky sexual behaviors among young adults. However, few studies have evaluated the psychometric properties of the SSBQ, such as how well the survey items discriminate between individuals who engage in safer versus riskier sexual behaviors (discrimination), and whether the items function equivalently for men versus women (differential item functioning). In the current study, we applied psychometric modeling to a dataset of 1,094 young …


Investigating Epigenetic Dysregulation Of Long Non-Coding Rnas In Glioblastoma And Glioma Stem Cells, Pujita Kellampalli, Mansi Gandhi, Dhruv Patel, Nehal Pant, Mihika Mishra, Shehr Bano, Aaron Basnyet Apr 2026

Investigating Epigenetic Dysregulation Of Long Non-Coding Rnas In Glioblastoma And Glioma Stem Cells, Pujita Kellampalli, Mansi Gandhi, Dhruv Patel, Nehal Pant, Mihika Mishra, Shehr Bano, Aaron Basnyet

Undergraduate Student Symposium

Glioblastoma multiforme (GBM) or Grade IV glioma is a very aggressive form of brain tumor with an overall survival rate of 15 months. The tumor contains glioma stem cells (GSCs) that are resistant to existing therapies. Long non-coding RNAs such as DNA methylation are implicated in epigenetic dysregulation of GBM and GSCs. In this study, we screened lncRNAs with altered DNA methylation in both tumor cells and GSCs compared to normal neural cells using 450K methylation array data. We identified 508 methylation sites (320 lncRNAs) that were either hypermethylated (or gained methylation) or hypomethylated (lost methylation) in GBM and GSCs. …


Creatine In Dementia And The Aging Brain, Dylan Kuni Apr 2026

Creatine In Dementia And The Aging Brain, Dylan Kuni

Undergraduate Student Symposium

Dementia is a syndrome that interferes with cognitive functions and an individual's ability to function independently. Dementia includes several subtypes caused by different neuropathologies, with Alzheimer's disease (AD) being the most common form. AD is characterized by the accumulation of amyloid beta plaques and neurofibrillary tau tangles in the brain, associated with neuroinflammation, oxidative stress, and deficits in energy metabolism. While treatments for AD exist, the efficacy, safety, and cost are a concern, highlighting the need for additional prevention and treatment strategies. This literature review examines the role of creatine in brain health and disease, including AD and related dementias. …