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Compact Midwave Infrared System (Cmis) For Feature Tracking, Michael Kelly, Warren Chen, James L. Carr Aug 2023

Compact Midwave Infrared System (Cmis) For Feature Tracking, Michael Kelly, Warren Chen, James L. Carr

Small Satellite Conference

The Compact Midwave Infrared System (CMIS) is a multi-angle, multi-spectral radiometer designed for high-spatial resolution stereo imaging in the shortwave infrared (SWIR)/midwave infrared (MWIR). The unique design of CMIS enables the capability to track diverse targets ranging from hot wildfires to cold clouds. CMIS is a low-size, -weight and -power (SWaP) instrument that can be accommodated on a small-satellite constellation to enable a rapid revisit rate needed for characterizing dynamic scenes. CMIS employs mature stereographic techniques to retrieve object heights and motion vectors that are free of the ambiguities between height assignment and along-track motions that are apparent in some …


Analysis Of An Energetic Electron Injection At Geo Using Falconseed: A Low Swap-C, Cubesat-Compatible Instrument For Space Environments, Anthony J. Rogers, Carlos A. Maldonado, John D. Williams, Matthew G. Mcharg, Robert A. Vincent, Richard Balthazor Aug 2023

Analysis Of An Energetic Electron Injection At Geo Using Falconseed: A Low Swap-C, Cubesat-Compatible Instrument For Space Environments, Anthony J. Rogers, Carlos A. Maldonado, John D. Williams, Matthew G. Mcharg, Robert A. Vincent, Richard Balthazor

Small Satellite Conference

We present a detailed analysis of an energetic electron injection (10s - 100s keV) observed at geostationary Earth orbit (GEO) on March 5, 2022 in order to highlight the capabilities of the Falcon Solid-state Energetic Electron Detector (SEED). The high time- and energy-resolution of SEED are used to quantify the dispersion of the injection front and to explore the morphology of the energy distribution throughout the injection encounter. Observations of the same event from nearby platforms are included for context. The SEED is a CubeSat compatible, single element particle telescope, designed to measure 14 to 145keV electrons in GEO. The …


The Pandora Smallsat: Mission Overview, Jordan Karburn, Pete Supsinskas, Hilary Johnson, Maricris Schneider, Elisa Quintana, Jessie Dotson, Knicole Colon, Tom Barclay, Christina Hedges, Jessie Dotson Aug 2023

The Pandora Smallsat: Mission Overview, Jordan Karburn, Pete Supsinskas, Hilary Johnson, Maricris Schneider, Elisa Quintana, Jessie Dotson, Knicole Colon, Tom Barclay, Christina Hedges, Jessie Dotson

Small Satellite Conference

The NASA Pioneers Program is tasked with performing compelling astrophysics science at lower cost, with smaller hardware, compared to Explorers Program missions. The Pandora SmallSat was selected as an inaugural Pioneers mission. Pandora uses an aluminum, 45-cm, dual channel Cassegrain telescope as its scientific instrument. The instrument will obtain the first dataset of simultaneous, multiband, long-baseline observations of exoplanets and their host stars. The goal is to use these data to reliably characterize planetary atmospheres by disentagling star and planet signals in transmission spectra.

Early in project formulation, the Pandora team developed a suite of high-fidelity parametrized simulation and modeling …


Machine Learning Techniques To Predict The Air Quality Using Meteorological Data In Two Urban Areas In Sri Lanka, Lakindu Mampitiya, Namal Rathnayake, Lee P. Leon, Vishwanadham Mandala, Hazi Md. Azamathulla, Sherly Shelton, Yukinobu Hoshino, Upaka Rathnayake Aug 2023

Machine Learning Techniques To Predict The Air Quality Using Meteorological Data In Two Urban Areas In Sri Lanka, Lakindu Mampitiya, Namal Rathnayake, Lee P. Leon, Vishwanadham Mandala, Hazi Md. Azamathulla, Sherly Shelton, Yukinobu Hoshino, Upaka Rathnayake

Department of Earth and Atmospheric Sciences: Faculty Publications

The effect of bad air quality on human health is a well-known risk. Annual health costs have significantly been increased in many countries due to adverse air quality. Therefore, forecasting air quality-measuring parameters in highly impacted areas is essential to enhance the quality of life. Though this forecasting is usual in many countries, Sri Lanka is far behind the state-of-the-art. The country has increasingly reported adverse air quality levels with ongoing industrialization in urban areas. Therefore, this research study, for the first time, mainly focuses on forecasting the PM10 values of the air quality for the two urbanized areas …


Cooperative 3d Printing Platform, Wenchao Zhou, Lucas G. Marques, Robert Austin Williams Aug 2023

Cooperative 3d Printing Platform, Wenchao Zhou, Lucas G. Marques, Robert Austin Williams

Patents Granted

A 3-D printing system comprising a plurality of printers. The printers are motorized to allow movement in X and Y directions or to rotate freely. Each printer may have one or more printheads. Also provided is a surface independent from said printers adapted to receive a printed object.


Secondary Features Of Importance For A Url Ranking, Atajan Abdyyev Aug 2023

Secondary Features Of Importance For A Url Ranking, Atajan Abdyyev

Dissertations and Theses

This paper investigates the impact of secondary ranking factors on webpage relevance and rankings in the context of Search Engine Optimization (SEO), focusing on the jewelry domain within the United States e-commerce market. By generating a keyword list related to jewelry and retrieving top URLs from Google's search results, the study employs machine learning models including XGBoost, CatBoost, and Linear Regression to identify key features influencing webpage relevance and rankings.The findings highlight specific optimal ranges for features like Outlinks, Unique Inlinks, Flesch Reading Ease Score, and others, indicating their significant impact on better rankings. Notably, Random Forest model performed best …


Analisis Faktor-Faktor Yang Berhubungan Terhadap Keselamatan Di Tempat Kerja Pada Pt. X Semasa Pandemi Covid-19, Muhammad Faqih Hartono, Fatma Lestari Aug 2023

Analisis Faktor-Faktor Yang Berhubungan Terhadap Keselamatan Di Tempat Kerja Pada Pt. X Semasa Pandemi Covid-19, Muhammad Faqih Hartono, Fatma Lestari

National Journal of Occupational Health and Safety

PT X Unit Citeureup is the largest cement manufacturing industrial plant in the world. The industrial processes in PT X Unit Citeureup involve a variety of processes, materials, and hazardous works. Thus, the work process in it causes a lot of occupational safety and health risks. In addition, at this time PT X Unit Citeureup is also facing the challenges of the COVID-19 pandemic just like other industries. This situation can have a negative impact on both employees and management of PT X Unit Citeureup. Based on this situation, the establishment of safety in the workplace is something that must …


Analisis Hubungan Faktor Fisik Dan Individu Terhadap Prevalensi Keluhan Musculoskeletal Disorder (Msds) Pada Pekerja Cv Bengkel Otomotif Tahun 2022, Hamzah Fansuri Fajri, Robiana Modjo Aug 2023

Analisis Hubungan Faktor Fisik Dan Individu Terhadap Prevalensi Keluhan Musculoskeletal Disorder (Msds) Pada Pekerja Cv Bengkel Otomotif Tahun 2022, Hamzah Fansuri Fajri, Robiana Modjo

National Journal of Occupational Health and Safety

Complaints of musculoskeletal disorders (MSDs) in general can occur due to contraction or excessive loading of muscles or bones. One example of an activity that can trigger the incidence of musculoskeletal disorders (MSDs) is manual material handling work. Manual material handling work is still commonly found in the work done at CV Bengkel Otomotif. This study focuses on looking at the relationship between physical and individual variables with complaints of musculoskeletal disorders (MSDs) in CV Bengkel Otomotif workers. This research is a cross-sectional study with quick exposure check and nordic body map instruments. Of the 60 workers who became respondents …


A Critical Inter-Subunit Interaction For The Transmission Of The Allosteric Signal In The Agrobacterium Tumefaciens Adp-Glucose Pyrophosphorylase, Hiral Patel, Gabriela Martinez-Ramirez Ms., Emily Dobrzynski, Alberto A. Iglesias, Dali Liu, Miguel Ballicora Aug 2023

A Critical Inter-Subunit Interaction For The Transmission Of The Allosteric Signal In The Agrobacterium Tumefaciens Adp-Glucose Pyrophosphorylase, Hiral Patel, Gabriela Martinez-Ramirez Ms., Emily Dobrzynski, Alberto A. Iglesias, Dali Liu, Miguel Ballicora

Chemistry: Faculty Publications and Other Works

ADP-glucose pyrophosphorylase is a key regulatory enzyme involved in starch and glycogen synthesis in plants and bacteria, respectively. It has been hypothesized that inter-subunit communications are important for the allosteric effect in this enzyme. However, no specific interactions have been identified as part of the regulatory signal. The enzyme from Agrobacterium tumefaciens is a homotetramer allosterically regulated by fructose 6-phosphate and pyruvate. Three pairs of distinct subunit-subunit interfaces are present. Here we focus on an interface that features two symmetrical interactions between Arg11 and Asp141 from one subunit with residues Asp141 and Arg11 of the neighbor subunit, respectively. Previously, scanning …


Regulation Of Stress Responses And Membrane Morphology By Dspa In Synechocystis Sp. Pcc 6803, Rebekah Kathryn White Aug 2023

Regulation Of Stress Responses And Membrane Morphology By Dspa In Synechocystis Sp. Pcc 6803, Rebekah Kathryn White

Theses and Dissertations

In the world of microorganisms, cyanobacteria are a uniquely skilled powerhouse. They participate in global nutrient and carbon cycling. They have the ability to photosynthesize, which allows them to use sunlight and carbon dioxide to produce cellular energy. However, photosynthesis has a lot of points were environmental stresses can interfere, increasing the chances of oxidative stress and nutrient imbalances that can amplify deleterious effects. One regulator in particular will be the target of this study. DspA, also known as Hik33, is a histidine kinase that perceives and regulates multiple overlapping stress responses. In this project, abiotic stress effects will be …


August 8, 2023 Ereporter, University Of Alabama At Birmingham Aug 2023

August 8, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Supporting The “Virtuous Cycle” In Urban Ecosystems: How Research Can Inform Plans, Policies, And Projects That Impact Urban Resilience, Michele Romilini, Sophie S. Parker, Gregory B. Pauly, Eric M. Wood Aug 2023

Supporting The “Virtuous Cycle” In Urban Ecosystems: How Research Can Inform Plans, Policies, And Projects That Impact Urban Resilience, Michele Romilini, Sophie S. Parker, Gregory B. Pauly, Eric M. Wood

Center for Urban Resilience Scholarship

No abstract provided.


Draft Final 2023 Rmap Baptist Student Union (Former Mckinley School) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc. Aug 2023

Draft Final 2023 Rmap Baptist Student Union (Former Mckinley School) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Final Approved Request For Change Bg-2023-01 To Final Bpsou Hydrocarbon Sampling And Treatability Study Quality Assurance Project Plan (Qapp), Josh Bryson Aug 2023

Final Approved Request For Change Bg-2023-01 To Final Bpsou Hydrocarbon Sampling And Treatability Study Quality Assurance Project Plan (Qapp), Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Improving Peripheral Nerve Regeneration Through Rehabilitation And Biomaterial-Based Drug Delivery Strategies, Yunfan Kong Aug 2023

Improving Peripheral Nerve Regeneration Through Rehabilitation And Biomaterial-Based Drug Delivery Strategies, Yunfan Kong

Theses & Dissertations

Peripheral nerve injury (PNI) is a common problem worldwide, with trauma being a common cause. PNI can lead to loss of sensory and motor functions, chronic neuropathic pain, and mental health issues, significantly impacting patients' family life, work, and social situation. Recent studies revealed that beyond the topical injury site at peripheral nerves, PNIs can also induce dysfunctions in the central nervous system (CNS) by causing maladaptive plasticity, which will result in exaggeration and exacerbation of the pathological condition caused by primary injuries. The common therapy strategies for PNI treatment are using sutures, nerve autografts or conduits in cases requiring …


Crop Monitoring And Nutrient Prediction Using Satellite Imagery And Soil Data, Olatunde D. Akanbi, Brian Gonzalez Hernandez, Erika I. Barcelos, Arafath Nihar, Laura S. Bruckman, Yinghui Wu, Jeffrey Yarus, Roger H. French Aug 2023

Crop Monitoring And Nutrient Prediction Using Satellite Imagery And Soil Data, Olatunde D. Akanbi, Brian Gonzalez Hernandez, Erika I. Barcelos, Arafath Nihar, Laura S. Bruckman, Yinghui Wu, Jeffrey Yarus, Roger H. French

Student Scholarship

No abstract provided.


Ten Questions Concerning Smart And Healthy Built Environments For Older Adults, Sanjay Kumar, Samuel H. Underwood, Julie L. Masters, Natalie A. Manley, Iason Konstantzos, Josephine Lau, Ryan Haller, Lily M. Wang Aug 2023

Ten Questions Concerning Smart And Healthy Built Environments For Older Adults, Sanjay Kumar, Samuel H. Underwood, Julie L. Masters, Natalie A. Manley, Iason Konstantzos, Josephine Lau, Ryan Haller, Lily M. Wang

Durham School of Architectural Engineering and Construction: Faculty Publications

In the past decade, the term ‘global aging’ has gained much attention among researchers, policymakers, civil societies, and governments worldwide. The continuous decline in fertility rates and increased life expectancy have resulted in an ongoing demographic transition where the share of adults aged 65 or older is increasing and outnumbering children younger than five years. In the United States and other developed countries, this rapid demographic transition is expected to continue to strain the existing health infrastructure as it becomes increasingly challenging to ensure healthy living environments for older adults. The ten questions and answers in this paper have been …


Gambaran Kejadian Computer Vision Syndrome Dan Faktor Risikonya Pada Mahasiswa Fkm Ui Di Masa Pandemi Covid-19, Rahadian Muhamad Shadik, Baiduri Widanarko Aug 2023

Gambaran Kejadian Computer Vision Syndrome Dan Faktor Risikonya Pada Mahasiswa Fkm Ui Di Masa Pandemi Covid-19, Rahadian Muhamad Shadik, Baiduri Widanarko

National Journal of Occupational Health and Safety

Due to the Covid-19 pandemic, many activities that were previously carried out offline have turned into online, including the education sector. This condition increased the use duration of electronic devices with digital screens/VDT, especially among students. It is one of the risk factors for Computer Vision Syndrome. Apart from duration, several risk factors are also associated with Computer Vision Syndrome. The aims of this study are to see an overview of Computer Vision Syndrome incidence and analyze the relationship between Computer Vision Syndrome incidence and its risk factors in regular (S1) and postgraduate (S2) students, FKM UI during the Covid-19 …


Effects Of High School Engineering Course Availability And Participation On Engineering School Recruitment, Discipline Selection, Persistence Attitudes, And Self-Efficacy, Kristin S. Sandberg Aug 2023

Effects Of High School Engineering Course Availability And Participation On Engineering School Recruitment, Discipline Selection, Persistence Attitudes, And Self-Efficacy, Kristin S. Sandberg

Theses and Dissertations

The need for engineers in the workforce continues to grow. Filling this need requires recruiting future engineers to colleges and universities and retaining them through to degree completion. However, this is easier said than done. Universities are tasked with attempting to keep up with the demand for new engineers and companies are searching for new engineers to recruit. One avenue that has been established in the attempt to reach students for engineering is offering engineering or STEM classes in K-12 schools.

This dissertation looked at engineering classes offered at the high school level. These courses were analyzed for relationships with …


Script-Based Design Toolkit For Digitally Fabricated Concrete Applied To Terrain-Responsive Retaining Wall Design, Nada Abdel-Aziz Aug 2023

Script-Based Design Toolkit For Digitally Fabricated Concrete Applied To Terrain-Responsive Retaining Wall Design, Nada Abdel-Aziz

Theses and Dissertations

The potential of digitally fabricated concrete (DFC) to produce terrain responsive designs has not been thoroughly investigated. Existing research indicates diverse benefits of DFC, such as the rapid fabrication of customized geometries. This research clarifies the advantages and design processes involved in creating site-specific DFC structures. Existing literature is analyzed to provide an overview of fabrication methods and their impacts and constraints on design. Parametric scripting is used to develop an interactive toolkit that integrates aesthetic, structural, and fabrication considerations into the design process. This toolkit specifically focuses on unreinforced retaining walls with interchangeable modules for terrain analysis, wall form …


Experiences Of First-Generation Students In A Large Public University In Ghana : A Phenomenological Study, Jacob Oppong Nkansah Aug 2023

Experiences Of First-Generation Students In A Large Public University In Ghana : A Phenomenological Study, Jacob Oppong Nkansah

Lingnan Theses (Doctoral degree)

In this study, first-generation students (FGS) experiences in the higher education system of Ghana were explored. Only a few studies in Africa, notably Ghana, have focused on the concept of FGS. FGS are conceptualized as learners whose parents didn’t complete or attend university and are the first in their nuclear families to seek for higher education. This research looked into FGS experiences at the University of Education Winneba, which is a large public university viewed as a haven for FGS in Ghana because of its mandate to train teachers for immediate employment. The study explored FGS motivations for pursuing higher …


It's Nerve Racking: The Lived Experiences Of New Graduate Clinical Care Nurses Using Simulation As Part Of An Orientation Program, Robert L. Kerner Jr. Aug 2023

It's Nerve Racking: The Lived Experiences Of New Graduate Clinical Care Nurses Using Simulation As Part Of An Orientation Program, Robert L. Kerner Jr.

Dissertations

The nursing profession has adopted high fidelity simulation (HFS) on the premise that it provides suitable opportunities for experiential learning in a non-threatening environment and it will improve clinical skills and critical thinking through repetition and reflective practice. Numerous quantitative studies have examined the effect of HFS on skill acquisition, critical thinking and teamwork, predominantly with experienced clinicians. The voice of the learner has been conspicuously absent in the discussion. The phenomenon of interest in this study was the experience of simulation for new graduate nurses. The participants were recruited using a purposive technique, and each underwent a comprehensive interview, …


Analisis Kasus Kecelakaan Pemboran Pada Industri Migas Di Pt.X Berdasarkan Faktor Manusia Tahun 2022, Siti Khodijah, Mufti Wirawan Aug 2023

Analisis Kasus Kecelakaan Pemboran Pada Industri Migas Di Pt.X Berdasarkan Faktor Manusia Tahun 2022, Siti Khodijah, Mufti Wirawan

National Journal of Occupational Health and Safety

Oil and gas drilling activities have associated high risks. 80% of the causes of drilling accidents are caused by human performance. In 2020, drilling activities at PT. X accounts for 3 out of 8 accidents and the common cause that occurs due to human factors. Unsafe acts are the main cause of drilling accidents in the oil and gas industry. This study discusses the analysis of cases of oil and gas drilling accidents at PT.X from the point of view of human factors. The purpose of this study is to analyze the contributing factors of active and latent failure and …


Increasing Exercise In Individuals With Autism Spectrum Disorder: A Systematic Review Of Instructional Strategies, Jacob Moak Aug 2023

Increasing Exercise In Individuals With Autism Spectrum Disorder: A Systematic Review Of Instructional Strategies, Jacob Moak

Seton Hall University Dissertations and Theses (ETDs)

It has been found that children with autism spectrum disorder (ASD) are 1.6 times more likely to be obese compared to neurotypically developing children. Individuals with ASD often struggle with motor skills and experience sensory processing difficulties, which can make it difficult to participate in regular physical activity. Because of this, it is crucial to find exercise methods that are enjoyable, practical and that are tailored to the specific needs of individuals with ASD in order to help them maintain a healthy lifestyle. The current systematic review investigated the research literature on interventions used to teach exercise to individuals with …


The Effectiveness Of Microcurrent Neurofeedback On Depression, Anxiety, Post-Traumatic Stress Disorder, And Quality Of Life, Gloria Duke, Courtney N. Yotter, Beverly Sharifian, Gary Duke, Sandra Petersen Aug 2023

The Effectiveness Of Microcurrent Neurofeedback On Depression, Anxiety, Post-Traumatic Stress Disorder, And Quality Of Life, Gloria Duke, Courtney N. Yotter, Beverly Sharifian, Gary Duke, Sandra Petersen

Nursing Faculty Publications and Presentations

Background: The world faces a mental health crisis with elevated rates of depression, anxiety, and post-traumatic stress, leaving a profound impact on daily quality of life (QOL). Current treatments show varying degrees of efficacy and carry burdensome challenges. Evidence exists for use of an innovative neurotechnology to reduce symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD), but the science is lacking for use in the general population. Purposes: The purpose of this pilot study was to explore the effects of microcurrent neurofeedback on depression, anxiety, PTSD symptoms, and QOL in adults. Methodology: This was a one-group, exploratory pilot study …


Interactions Between Traditional And Reversed It Adoption: How Incumbent Devices Affect Cross-Situational Specialization Of New Entries, Christopher Agyapong Siaw, Jack Cadeaux, Dirk Meissner, Adrian Payne, David Sarpong Aug 2023

Interactions Between Traditional And Reversed It Adoption: How Incumbent Devices Affect Cross-Situational Specialization Of New Entries, Christopher Agyapong Siaw, Jack Cadeaux, Dirk Meissner, Adrian Payne, David Sarpong

Plymouth Business School

This article proposes a cross-situational specialization framework for what, at its introduction, was a newer generation personal computer (PC) device (a tablet computer). With use as the basis for continuance adoption as the theoretical lens, this article explores how the tablet coexists as a substitute- and a complement-in-use with incumbent PC(s). To test a model consisting of cross-situational use patterns, determinants, and outcomes, this article develops and analyzes the results of a survey of tablet computer use in a learning and education context. The results show a stronger coexistence between the tablet and the incumbent devices when the devices perform …


Vertical Federated Learning Using Autoencoders With Applications In Electrocardiograms, Wesley William Chorney Aug 2023

Vertical Federated Learning Using Autoencoders With Applications In Electrocardiograms, Wesley William Chorney

Theses and Dissertations

Federated learning is a framework in machine learning that allows for training a model while maintaining data privacy. Moreover, it allows clients with their own data to collaborate in order to build a stronger, shared model. Federated learning is of particular interest to healthcare data, since it is of the utmost importance to respect patient privacy while still building useful diagnostic tools. However, healthcare data can be complicated — data format might differ across providers, leading to unexpected inputs and incompatibility between different providers. For example, electrocardiograms might differ in sampling rate or number of leads used, meaning that a …


Comparing Current Consistency And Electrical Resistance Of Wearable Photovoltaic Cells Pre- And Post-Laundering And Pre- And Post-Corrosion Resistance Testing Conditions., Amit Talukder Aug 2023

Comparing Current Consistency And Electrical Resistance Of Wearable Photovoltaic Cells Pre- And Post-Laundering And Pre- And Post-Corrosion Resistance Testing Conditions., Amit Talukder

Theses and Dissertations

Photovoltaic(PV) technology is promising due to its natural availability among energy harvesting technologies. There is a growing need for sustainable power sources that can function without being connected to a power source or needing regular battery replacements. Wearable PV cells are gaining popularity in different applications. However, most companies produce wearable PVs for terrestrial applications. Research on wearable PV applications for the marine environment remains limited because these cells suffer from several issues. This research compares commercially sourced wearable PV cells' maximum current consistency and electrical resistance for two testing conditions. The researcher followed standardized methods for these two laundering …


Dune To Shore: The Relationship Between Vegetative Dune Systems And Shoreline Stability In Barrier Islands, Walter Hastings Hogue Aug 2023

Dune To Shore: The Relationship Between Vegetative Dune Systems And Shoreline Stability In Barrier Islands, Walter Hastings Hogue

Theses and Dissertations

Dauphin, Petit Bois, and Horn Island form the Alabama gulf-barrier chain directly south of Mobile Bay. Many studies have targeted local climate stressors and the flux of longshore currents as factors for erosional and accretional changes on these islands, but little attention is paid to the degradation of their vegetative dune-systems as a contributor to their shoreline morphology (Hanley et al., 2014; Smith, 2018; Byrnes, 2010). This study fills this literary gap, utilizing GIS raster classification and Digital Shoreline Analysis System to measure vegetative health and shoreline change on these islands and verify a relationship between these two factors. The …


Nanoscale Modeling Of Membrane Systems Under Mechanical Deformation In Traumatic Brain Injury Using Molecular Dynamics, Anh Thi Ngoc Vo Aug 2023

Nanoscale Modeling Of Membrane Systems Under Mechanical Deformation In Traumatic Brain Injury Using Molecular Dynamics, Anh Thi Ngoc Vo

Theses and Dissertations

Neuronal membrane disruption and mechanoporation are nanoscale damage mechanisms that critically affect brain cell viability during traumatic brain injury (TBI). These nanoscale cellular impairments are elusive in experiments and necessitate in silico approaches such as molecular dynamics (MD) simulations. Implementing MD, this research aims to investigate the effects of different key factors related to membrane deformation and damage, including force field resolutions, lipid compositions, and loading conditions.

To examine the impact of force field resolution, MD deformation simulations were conducted on 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC) lipid bilayer membranes, using all-atom (AA), united-atom (UA), and coarse-grained Martini (CG-M) force fields. The mechanical responses …