Digital Commons Network^™

Replicating Single-Cycle Adenovirus Vectors Generate Amplified Influenza Vaccine Responses, Catherine M. Crosby, William E. Matchett, Stephanie S. Anguiano-Zarate, Christopher A. Parks, Eric A. Weaver, Larry R. Pease, Richard J. Webby, Michael A. Barry

Nebraska Center for Virology: Faculty Publications

Head-to-head comparisons of conventional influenza vaccines with adenovirus (Ad) gene-based vaccines demonstrated that these viral vectors can mediate more potent protection against influenza virus infection in animal models. In most cases, Ad vaccines are engineered to be replication-defective (RD-Ad) vectors. In contrast, replication-competent Ad (RC-Ad) vaccines are markedly more potent but risk causing adenovirus diseases in vaccine recipients and health care workers. To harness antigen gene replication but avoid production of infectious virions, we developed “single-cycle” adenovirus (SC-Ad) vectors. Previous work demonstrated that SC-Ads amplify transgene expression 100-fold and produce markedly stronger and more persistent immune responses than RD-Ad vectors …

Enrgy Tour 2000 : Tour Report 27 March - 8 April 2000, South Australia, Victoria, New South Wales., Department Of Agriculture And Food, Western Australia, Progress Rural Western Australia

All other publications

eNRGy tour 2000 - an opportunity for twenty young rural West Australians to travel to the Eastern States of Australia to explore opportunities for innovation, value adding and entrepreneurship that could be applied here in Western Australia on their return.

Fall 1984, Wmpg 90.9 Fm

WMPG Program Guides

WMPG program guide for fall 1984.

Includes notes from Program Director, information on shows and events, and schedule.