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Articles 40381 - 40410 of 1195582
Full-Text Articles in Entire DC Network
A Quantitative Casual-Comparative Study To Determine The Difference In Perception Of Inclusive Education Among Teachers In Preschool, Elementary And Middle School, Boimah G. Sayway
A Quantitative Casual-Comparative Study To Determine The Difference In Perception Of Inclusive Education Among Teachers In Preschool, Elementary And Middle School, Boimah G. Sayway
Doctoral Dissertations and Projects
This quantitative, causal-comparative research examines differences in Teacher Efficacy for Inclusive Practices (TEIP) scores based on perceptions of inclusive education among preschool, elementary, and middle school teachers. The study involved a survey of 450 teachers from three districts in a large Eastern city in the U.S., yielding 159 responses, which surpasses the minimum sample size of 126. Researchers assessed teachers' self-efficacy in inclusive instruction, collaboration, and behavior management using the TEIP scale, analyzing the data with the Statistical Package for the Social Sciences (SPSS) and a One-Way ANOVA. There was a statistically significant difference found between preschool and both elementary …
"It's About Time!" First-Year Generation Z African American Collegiate Male Time Management Practices: A Phenomenological Study, James Delano Payne Douglas
"It's About Time!" First-Year Generation Z African American Collegiate Male Time Management Practices: A Phenomenological Study, James Delano Payne Douglas
Doctoral Dissertations and Projects
The purpose of this qualitative transcendental phenomenological study was to understand the impact of time management practices on the experiences of academic integration and social integration for first-year Generation Z African American collegiate males. African American collegiate male retention, persistence, and completion rates are lower than those of other higher education demographics. The theory guiding this study was Astin’s (1984, 1999) student involvement theory which hypothesized that student learning and personal growth results from the degree of involvement measured by the amount of time personally invested in the educational process. The central research question is “How do first-year Generation Z …
English As A Second Language Nurse Experiences With Collaborative Learning During Pre-Licensure, Baccalaureate Nursing Education: A Phenomenological Study, Candice Tart Phillips
English As A Second Language Nurse Experiences With Collaborative Learning During Pre-Licensure, Baccalaureate Nursing Education: A Phenomenological Study, Candice Tart Phillips
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to understand how ESL nurses experienced collaborative learning with their native English-speaking peers in traditional baccalaureate-accredited nursing programs across the United States. The theories guiding this study were the Social Learning Theory (SLT) of Academic Self-Efficacy (ASE) by Albert Bandura and the Sociocultural Theory of Zone of Proximal Development (ZPD) by Lev Vygotsky. The central investigative research question was: What are the lived experiences of novice ESL nurses who participated in collaborative learning with their native English-speaking peers during baccalaureate nursing education? Sampling methods used included a purposive and a snowball sample …
A Hermeneutic Phenomenological Study Of Missouri K-12 Public School Educators' Expression Experiences On Social Media, Jacob Murphy Small
A Hermeneutic Phenomenological Study Of Missouri K-12 Public School Educators' Expression Experiences On Social Media, Jacob Murphy Small
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to understand how Missouri public school educators experience their expression regarding social media, seeking to understand their views and lived experiences with expressing themselves on social media. The theory guiding this study was Bandura’s social cognitive theory as it explains the learned behavior of teachers exercising their agency through social media. The central research question for this study was, what are the lived experiences of Missouri K-12 public school educators regarding their expression on social media? This study examined the lived experiences of Missouri public school teachers, gaining an insight to teachers’ …
Revealing Roots: Examining The Intersection Of Trauma, Mental Health, And Bioecological Impact On Pentecostal Black Male Pastors, Dreama Delicia Cole
Revealing Roots: Examining The Intersection Of Trauma, Mental Health, And Bioecological Impact On Pentecostal Black Male Pastors, Dreama Delicia Cole
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to describe Pentecostal Black male pastors in their understanding of (or experiences with) trauma and mental health in the context of the inclusion of bioecological effects and any thoughts about the potential impact on their congregations in California. The chosen theories complement the lived experiences of these pastors. Based on the research questions, interview questions, and data analysis, the following themes and one subtheme emerged: Their Roots Tell a Story: Lived Experiences of Identity Formation and Early Trauma with subtheme Rejection: Lived Experience of Exclusion and Emotional Wounding, Revelation: Lived Experiences of …
Paul’S Christological Hermeneutics Of The Psalter In The Book Of Romans, Finny Samuel
Paul’S Christological Hermeneutics Of The Psalter In The Book Of Romans, Finny Samuel
Doctoral Dissertations and Projects
This study examines the pivotal role of the Psalter in shaping Paul’s theological articulation of justification by faith in the Epistle to the Romans. The central argument asserts that Paul’s Christological hermeneutic of the Psalter serves as a foundational framework for the forensic and legal language employed in his presentation of justification by faith in Romans. The study systematically explores Paul’s theological interpretation of direct quotations from the Psalter in Romans, illuminating the forensic dimensions integral to his argumentation. Through rigorous exegetical analysis of these quotations, it is demonstrated that Paul consistently interprets these texts through the lens of Christ’s …
The Impact Of Implementing A House System At East Richland Christian Schools: A Dissertation-In-Praxis, Travis Johnson Mckinley
The Impact Of Implementing A House System At East Richland Christian Schools: A Dissertation-In-Praxis, Travis Johnson Mckinley
Doctoral Dissertations and Projects
This dissertation-in-praxis examines the implementation of a House System at East Richland Christian Schools (ERCS), a private Grades 7-12 institution in Saint Clairsville, Ohio, to address deficiencies in the traditional small group model, including limited student engagement, leadership development, spiritual growth, and school spirit. Grounded in Burns’ (1978) Transformational Leadership Theory and biblical principles, the study replaced gradeand gender-segregated groups with four randomized, co-ed houses (Amare, Fidem, Spero, Veritas) for 50 students and eight teachers. The project aimed to create a spirited Christian community through weekly competitions, leadership opportunities, and spiritual activities. Using a mixed-methods approach under the Stake Model, …
Immigration Federalism In The United States: Texas Case Studies, Kelly A. Atwell
Immigration Federalism In The United States: Texas Case Studies, Kelly A. Atwell
Doctoral Dissertations and Projects
The purpose of this qualitative case study was to understand the immigration federalism framework for public administrators in Texas border cities. This study aimed to explore the experiences and perspectives of public administration officials in managing immigration challenges and integrating immigrant populations into their communities. The guiding theory is Friedman’s immigration federalism framework, emphasizing state and local actor involvement in developing immigration policies (Friedman, 2022). Friedman’s framework explains why cascading effects of federal level actions are inapplicable at the local level and how a theory meeting communities’ needs is preferential to the removed policies instituted at higher levels of government. …
Educator Self-Efficacy In Implementing College Readiness Curriculum For English Language Learners: A Qualitative Hermeneutical Phenomenology, Emily Rose Munevar
Educator Self-Efficacy In Implementing College Readiness Curriculum For English Language Learners: A Qualitative Hermeneutical Phenomenology, Emily Rose Munevar
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to describe the self-efficacious perspectives integrating college readiness among English Language Learners for K-12 educator professionals at schools in the Southcentral United States. The theory guiding this study was Bandura’s theory of self-efficacy, which guides the research by providing the facets of educator self-efficacy that were used to design research and interview questions. Self-efficacy theory breaks down into four parts: mastery experiences, vicarious experiences, social persuasion, and physiological feedback. The central research question of this research was: What are the self-efficacious experiences of K-12 educator professionals integrating college readiness for English language learner …
Exploring Lived Experiences Of Teachers Fostering Student Engagement In Classrooms In Government Secondary Schools In The Southwest Region Of Cameroon: A Phenomenological Study, Susan Etchu
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to understand the lived experiences of teachers fostering student engagement in classrooms in the Southwest Region of Cameroon. The theory guiding this study was Lev Vygotsky's sociocultural theory of cognitive development as it emphasizes the role of social interaction, cultural context, and language in shaping cognitive development. The central research question was: What are the lived experiences of teachers fostering student engagement in their classrooms in the Southwest Region of Cameroon? Data was collected from 13 teachers through interviews, focus groups, and observations. Seven major themes emerged: Impact of Sociopolitical Crisis, Academic …
The Impact Of Digital Communications And Social Media On Government Officials And The Political Sphere: A Case Study Of The Arab Spring Revolutions, Wurood Shaher
Doctoral Dissertations and Projects
This study investigates the dual role of social media as both a tool for political mobilization and a mechanism for government surveillance during the Arab Spring. Through in-depth qualitative interviews with 22 government officials from various Middle Eastern and North African countries, the research explores how social media influenced internal decision-making processes and external governmental responses during the uprisings. Employing the theory of structuration and the sociocultural tradition as its theoretical frameworks, the study uncovers the profound impact of social media on state power and public activism. Thematic analysis reveals several key themes, including the rapid adaptation of governmental strategies, …
A Hermeneutical Phenomenological Study Exploring Divorce In Blended Families, Steve Hudgins
A Hermeneutical Phenomenological Study Exploring Divorce In Blended Families, Steve Hudgins
Doctoral Dissertations and Projects
Marriages are supposed to be for a lifetime, but there is a gap in the research as to what is causing a high divorce rate in blended families. There is a research gap considering why divorce percentage rates are higher and more predictable than those of the first marriage. The causes of second divorces within blended families remain largely unexplored in the current reviewed literature; however, relationship studies are more prevalent on the specific roles, such as those of bio- and stepparents within the family. By revealing the research gap, researchers in the field of mental health can understand the …
The Impact Of Childhood Sexual Abuse On The Overall Well-Being Of White, Christian Female Survivors: A Phenomenology, Tassanee Sanchez
The Impact Of Childhood Sexual Abuse On The Overall Well-Being Of White, Christian Female Survivors: A Phenomenology, Tassanee Sanchez
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to understand the impact that childhood sexual abuse has on the biopsychosocial-spiritual health of White, Christian female survivors. The study revolved around three main research questions: (1) How do participants describe their lived experiences and articulate their understanding of the phenomenon of CSA? Participants described their lived experiences as a painful experience of betrayal. Surprisingly, the betrayal came not only from the perpetrator, but also from those close to the survivor who they trusted to protect them. (2) How do participants describe the impact CSA has on their biopsychosocial-spiritual well-being in adulthood? Participants …
Exploring The Essence Of Teacher Retention In A Christian School: A Multiple Case Study, Philip Rey Regualos
Exploring The Essence Of Teacher Retention In A Christian School: A Multiple Case Study, Philip Rey Regualos
Doctoral Dissertations and Projects
The purpose of this exploratory multiple case study was to understand the factors that contributed to teacher retention at two pre-K–12 Christian school associations of three schools, the Midwest Evangelical Christian School Association (MECSA) and the Rural Area Christian School Association (RACSA). In the research, teacher retention was generally defined as a teacher who is currently employed and intends to return next academic year as a teacher at this association. The theory guiding this study was Maslow’s hierarchy of needs. The central research question guiding the study is: How do teachers describe the factors that motivate them to return to …
Sanctification Of Marriage And Positive Religious Coping May Help Couples Be Resilient From Stress's Negative Influence, Amanda Sue Bills
Sanctification Of Marriage And Positive Religious Coping May Help Couples Be Resilient From Stress's Negative Influence, Amanda Sue Bills
Doctoral Dissertations and Projects
Marriage is the building block of society and as such is an important developmental stage. Unfortunately, studies suggest that stress could be harmful to marriages. However, many resilient factors have been found to protect marriages from stress such as good communication, secure attachments, gratitude and optimism, and religion. The Bible teaches that marriage was founded by God and is a sacred institution. Further, stress should be expected in life, is useful for learning and growth, and God will help his followers to cope with it. The current quantitative study sought to discover if viewing marriage as sacred and using positive …
Booker And The Bible: An Examination Of The Religious Rhetoric Of Booker T. Washington In Select Speeches And Writings And Its Impact On Audiences And Followers, Redunda L. Noble
Booker And The Bible: An Examination Of The Religious Rhetoric Of Booker T. Washington In Select Speeches And Writings And Its Impact On Audiences And Followers, Redunda L. Noble
Doctoral Dissertations and Projects
This study is an ideological analysis of the religious rhetoric of Booker T. Washington and its impact on his audiences and followers. Washington became one of the most powerful Black men of the Progressive Era as leader of Tuskegee Normal and Industrial Institute in Alabama. He supported industrial education for Blacks, but rejected the political protest model demanding civil rights. He developed an educational program advocating individual agency to foster economic and spiritual improvement for Blacks. His advocacy grew out of his impoverished childhood slave experience and struggle to gain education after Emancipation in the Reconstruction South. Washington’s religious rhetoric …
Worldview Development And The K-12 Christian School Bible Curriculum: A Dissertation-In-Praxis, Shannon Michelle Juris
Worldview Development And The K-12 Christian School Bible Curriculum: A Dissertation-In-Praxis, Shannon Michelle Juris
Doctoral Dissertations and Projects
This dissertation-in-praxis explored the development of a biblical worldview in K-12 Christian schools, focusing on how these institutions’ curriculum choices shaped students’ perspectives through intentional integration of faith and education. Drawing on theories of worldview formation, educational philosophy, and Christian pedagogy, the study investigated the methods and curriculum employed by Christian schools to foster a biblical worldview in students. The research aimed to understand how curriculum selection across all grade levels contributed to the development of a biblical worldview. The study examined both the intended and actual outcomes of biblical worldview education by creating a curriculum guide for the current …
Pharmacogenomics-Guided Treatment Of Depression Evidence-Based Practice Scholarly Project, Richard A. Sonnier
Pharmacogenomics-Guided Treatment Of Depression Evidence-Based Practice Scholarly Project, Richard A. Sonnier
Doctoral Dissertations and Projects
Pharmacogenomics is a popular topic in psychiatry today that is poised to replace the outdated trial-and-error paradigm of prescribing psychotropic medications. For patients suffering from a myriad of psychiatric disorders, it has been a frustrating period for those who have struggled with multiple failed trials of medications before finding relief from debilitating depression, anxiety, and many other mood-dysregulating disorders. Often, patients are forced to endure several weeks or months of trying psychotropic agents with poor responses and intolerable side effects before finally finding a medication that yields a desired outcome. In some cases, no therapeutic response is ever achieved. With …
Phenomenological Study Of The Lived Experiences Of The Constraint Of Law Enforcement Under The De-Policing Movement, Darren A. Kenyon
Phenomenological Study Of The Lived Experiences Of The Constraint Of Law Enforcement Under The De-Policing Movement, Darren A. Kenyon
Doctoral Dissertations and Projects
The purpose of this qualitative and descriptive phenomenological study was to explore the lived experiences of law enforcement officers in relation to how the de-policing movement may have constrained their ability to proactively enforce the law and interact with the citizens they serve in Connecticut. This study employed Fritz Heider’s attribution theory as a theoretical framework. Data was collected through a series of semi-structured interviews conducted online via Zoom with 10 participants who were employed as police officers or sergeants for a municipal law enforcement agency in the State of Connecticut. These participants were selected through purposive and snowball sampling …
Houston Nationalism: The Life And Politics Of United States Senator Sam Houston, Jeremy Ager Pedigo
Houston Nationalism: The Life And Politics Of United States Senator Sam Houston, Jeremy Ager Pedigo
Doctoral Dissertations and Projects
Sam Houston had a long and distinguished career in public service, gaining the most notoriety as General of the Texas Army and President of the Republic of Texas. However, he served in the United States Senate longer than any other position he held. This dissertation examines the impact of his life events and political ideology on the decisions and actions he undertook as a Senator, culminating in the proposal of a new ideology called “Houston Nationalism.” This belief system was based on three principles; nationalism, engagement, and recognition, which are defined throughout the study. Nationalism represents Houston’s support for the …
Meanings And Understandings Of Racial-Ethnic Minority Prelicensure Associate Degree In Nursing And Bachelor Of Science In Nursing Students Who Experience Uncivil Faculty Behaviors In United States Nursing Programs: A Transcendental Phenomenological Inquiry, Lenora Valdez
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological qualitative study was to explore the meanings and understandings of racial-ethnic minority (REM) prelicensure Associate Degree in Nursing (ADN) and Bachelor of Science in Nursing (BSN) students who experience uncivil faculty behaviors in United States nursing programs. The literature points to a wide range of faculty behaviors that nursing students experience as incivility. However, little data was found in the literature regarding REM prelicensure ADN or BSN students’ experiences with nurse faculty incivility. Purposive snowball sampling was used to recruit 10 REM currently enrolled junior and senior prelicensure ADN and BSN students who experience …
From Riches To Rags : Deindustrialization And The Fall And Rise Of The Upstate Mill Towns Of South Carolina, Brian Patrick Worrill
From Riches To Rags : Deindustrialization And The Fall And Rise Of The Upstate Mill Towns Of South Carolina, Brian Patrick Worrill
Doctoral Dissertations and Projects
The collapse and subsequent deindustrialization of the textile industry in the late 20th century devastated dozens of small communities across the Piedmont. With the loss of their primary economic engine these towns struggled with the outmigration of professional services and small businesses, crippling poverty, high unemployment, and rampant crime. As South Carolina’s economic model evolved to adapt to the globalized economy of the 21st century its government funded reindustrialization efforts have focused on its already well developed urban core, a strategy that often neglects rural areas. Yet, despite having been overlooked the majority of these orphaned mill towns did not …
Responding To Leadership Change: A Qualitative Multi-Case Study Of Female Pastors And Their Congregations, Sharon Britz
Responding To Leadership Change: A Qualitative Multi-Case Study Of Female Pastors And Their Congregations, Sharon Britz
Doctoral Dissertations and Projects
The purpose of this qualitative multi-case study was to explore the lived experiences of female senior pastors and their congregants who have embraced leadership change from male to female. Although many denominations openly accept and ordain female pastors, and the number of women in pastoral leadership roles has risen, many women in ministry still face obstacles. Guided by the theory of change, in conjunction with liberation theology, this study addressed a gap in research related to the experience of female pastors in ministerial leadership, as minimal similar studies exist, and no other studies within the Congregational Christian Church were found. …
The Influence Of Military Mindset In Canine Selection For The Mitigation Of Ptsd Symptomology Within A Tennessee Veteran Population: A Phenomenological Study, Rachael Michelle Bandlow Thompson
The Influence Of Military Mindset In Canine Selection For The Mitigation Of Ptsd Symptomology Within A Tennessee Veteran Population: A Phenomenological Study, Rachael Michelle Bandlow Thompson
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to explore the influence of military mindset on personal canine selection through the lived experiences of Tennessee military veterans to enhance military cultural competency and aid in development of complimentary and integrative approaches to veteran mental health. Insufficient research exists into understanding the specific needs of reintegrating veterans and into the benefits of canine-assisted therapies. The theories which guided this study were Albert Bandura’s Social Cognitive Theory of Learning and Abraham Maslow’s Theory of Motivation. This qualitative study was further guided by axiological philosophical assumptions. Fifteen participants were recruited via email and selected …
Childhood Sexual Abuse And Posttraumatic Growth Among African American Women, Joyce B. Mckinley
Childhood Sexual Abuse And Posttraumatic Growth Among African American Women, Joyce B. Mckinley
Doctoral Dissertations and Projects
The purpose of this qualitative descriptive phenomenological study was to explore how African American women describe their lived experience of childhood sexual abuse (CSA), the resulting changes in their relationships with others, and how survivors describe experiences of posttraumatic growth (PTG). Childhood sexual abuse is a significant public health issue in the United States, with African American youth disproportionately impacted. Research has shown that racism-related stressors are related, and African Americans often draw on cultural and familial strengths. This study aims to describe factors contributing to PTG among African American women survivors of CSA. Based on the review of the …
Short Report: The Variants In Chek2 In Metastatic Uveal Melanoma, Mizue Terai, Rino S. Seedor, Usman Ashraf, Gretchen Hubbard, Sergei A. Koshkin, Marlana Orloff, Takami Sato
Short Report: The Variants In Chek2 In Metastatic Uveal Melanoma, Mizue Terai, Rino S. Seedor, Usman Ashraf, Gretchen Hubbard, Sergei A. Koshkin, Marlana Orloff, Takami Sato
Department of Medical Oncology Faculty Papers
No abstract provided.
Investigating Christian Counselors' Emphasis On Marriage Vows As A Sacred Covenant In Premarital Counseling, Lovie J. Faine
Investigating Christian Counselors' Emphasis On Marriage Vows As A Sacred Covenant In Premarital Counseling, Lovie J. Faine
Doctoral Dissertations and Projects
Proverbs 11:14 says, “Where no counsel is, the people fall: but in the multitude of counselors there is safety” (King James Bible, 2017; Proverbs 11:14). This proverb suggests that counsel can provide a level of security. Premarital counsel is a type of provisional assistance and guidance sought by couples seeking to shelter and strengthen their union. Within the church pastors and elders often provide Christian counseling to congregants for various reasons, including premarital counseling. The purpose of this phenomenological study is to discover pastors and elders that operate as Christian counselors’ emphasis on marriage vows as a sacred covenant within …
Are We Ready? A Phenomenological Study On Teachers' Perceptions Surrounding Readiness To Teach Diverse Communities And The Responsibility Of Teacher Preparation Programs, Ja'niece Tiara Whitehead
Are We Ready? A Phenomenological Study On Teachers' Perceptions Surrounding Readiness To Teach Diverse Communities And The Responsibility Of Teacher Preparation Programs, Ja'niece Tiara Whitehead
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to discover teachers’ lived experiences in their teacher education programs in regard to levels of preparedness to effectively teach racially, linguistically, and gender-diverse students. The theory guiding this study was Culturally Responsive Teaching (CRT), which refers to teaching students customs, characteristics, experiences, and perspectives as tools to enhance instruction and understanding of the complexities of society as well as the awareness that students dwell in varying circumstances. The central question directing this research study asked, “What are the lived experiences of teachers and their teacher education programs with diverse communities?” Participants of …
Rnase1-Driven Alk-Activation Is An Oncogenic Driver And Therapeutic Target In Non-Small Cell Lung Cancer, Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Chenhao Zhou, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung
Rnase1-Driven Alk-Activation Is An Oncogenic Driver And Therapeutic Target In Non-Small Cell Lung Cancer, Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Chenhao Zhou, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung
Faculty, Staff and Student Publications
Targeted therapy has achieved significant success in the treatment of non-small cell lung cancer (NSCLC), particularly in patients harboring common oncogenic driver mutations such as EGFR, KRAS, and ALK rearrangement. However, ~35-50% of NSCLC patients without tyrosine kinase mutation or rearrangement (non-mutated) cannot benefit from these targeted treatments, highlighting the urgent need for novel therapeutic strategies for this patient population. In this study, we report a non-canonical role of human secretory ribonuclease 1 (RNase1), which binds to and activates wild-type ALK in lung cancer cells, thereby triggering its downstream signaling pathway. RNase1-driven ALK-activation (RDAA) cells exhibit enhanced cell proliferation, migration, …
Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Siyi Ge, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia
Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Siyi Ge, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia
Faculty, Staff and Student Publications
Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore,