Digital Commons Network^™

Short Report: The Variants In Chek2 In Metastatic Uveal Melanoma, Mizue Terai, Rino S. Seedor, Usman Ashraf, Gretchen Hubbard, Sergei A. Koshkin, Marlana Orloff, Takami Sato

Department of Medical Oncology Faculty Papers

No abstract provided.

Investigating Christian Counselors' Emphasis On Marriage Vows As A Sacred Covenant In Premarital Counseling, Lovie J. Faine

Doctoral Dissertations and Projects

Proverbs 11:14 says, “Where no counsel is, the people fall: but in the multitude of counselors there is safety” (King James Bible, 2017; Proverbs 11:14). This proverb suggests that counsel can provide a level of security. Premarital counsel is a type of provisional assistance and guidance sought by couples seeking to shelter and strengthen their union. Within the church pastors and elders often provide Christian counseling to congregants for various reasons, including premarital counseling. The purpose of this phenomenological study is to discover pastors and elders that operate as Christian counselors’ emphasis on marriage vows as a sacred covenant within …

Are We Ready? A Phenomenological Study On Teachers' Perceptions Surrounding Readiness To Teach Diverse Communities And The Responsibility Of Teacher Preparation Programs, Ja'niece Tiara Whitehead

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study was to discover teachers’ lived experiences in their teacher education programs in regard to levels of preparedness to effectively teach racially, linguistically, and gender-diverse students. The theory guiding this study was Culturally Responsive Teaching (CRT), which refers to teaching students customs, characteristics, experiences, and perspectives as tools to enhance instruction and understanding of the complexities of society as well as the awareness that students dwell in varying circumstances. The central question directing this research study asked, “What are the lived experiences of teachers and their teacher education programs with diverse communities?” Participants of …

Rnase1-Driven Alk-Activation Is An Oncogenic Driver And Therapeutic Target In Non-Small Cell Lung Cancer, Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Chenhao Zhou, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung

Faculty, Staff and Student Publications

Targeted therapy has achieved significant success in the treatment of non-small cell lung cancer (NSCLC), particularly in patients harboring common oncogenic driver mutations such as EGFR, KRAS, and ALK rearrangement. However, ~35-50% of NSCLC patients without tyrosine kinase mutation or rearrangement (non-mutated) cannot benefit from these targeted treatments, highlighting the urgent need for novel therapeutic strategies for this patient population. In this study, we report a non-canonical role of human secretory ribonuclease 1 (RNase1), which binds to and activates wild-type ALK in lung cancer cells, thereby triggering its downstream signaling pathway. RNase1-driven ALK-activation (RDAA) cells exhibit enhanced cell proliferation, migration, …

Enriched Pathways In Gut Microbiome Predict Response To Immune Checkpoint Inhibitor Treatment Across Demographic Regions And Various Cancer Types, Xunhui Cai, Jennifer Y Cho, Lijun Chen, Yufeng Liu, Fenghu Ji, Siyi Ge, Hui Yu, Jianbo Shao, P Andrew Futreal, Boris Sepesi, Don Gibbons, Yaobing Chen, Guoping Wang, Chao Cheng, Meng Wu, Jianjun Zhang, Ansel Hsiao, Tian Xia

Faculty, Staff and Student Publications

Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore,

Association Between B-Cell Marker Expression And Runx1 Lesions In Acute Myeloid Leukemia, Beyond Runx1::Runx1t1 Fusion: Diagnostic Pitfalls With Mixed-Phenotype Acute Leukemia—B/Myeloid, Giby V George, Malgorzata Kajstura, Audrey N Jajosky, Hong Fang, Fatima Zahra Jelloul, W Richard Burack, L Jeffrey Medeiros, Wei Wang, Siba El Hussein

Faculty, Staff and Student Publications

Acute myeloid leukemia (AML) with RUNX1::RUNX1T1 fusion is well known to often demonstrate aberrant upregulation of CD19 expression. We studied the clinicopathologic and genetic features of 16 cases of AML with various RUNX1 lesions, including mutations, copy number gains, and translocations other than fusions with RUNX1T1. Most of these cases were classified as AML-myelodysplasia-related or AML-post-cytotoxic therapy based on the cytogenetic and molecular work-up. These neoplasms showed partial expression of one or more B-cell antigens by flow cytometry and/or immunohistochemistry, fulfilling the criteria for mixed-phenotype acute leukemia (MPAL)-B/myeloid (i.e., ≥20% blasts expressing B and myeloid lineage antigens) …

A Silence After Slaughter-House: Nineteenth-Century State Constitutional Substantive Rights, Liberties, And Privileges, Charles W. "Rocky" Rhodes

Louisiana Law Review

No abstract provided.

Mechanism Of Dna Replication Fork Breakage And Parp1 Hyperactivation During Replication Catastrophe, Pedro Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez, Gisselle Santiago, Brooke R Harris, Josefine Striepen, John Maciejowski, Abby M Green, Rémi Buisson

2020-Current year OA Pubs

Ataxia telangiectasia and Rad3-related (ATR) inhibition triggers a surge in origin firing, resulting in increased levels of single-stranded DNA (ssDNA) that rapidly deplete all available RPA. This leaves ssDNA unprotected and susceptible to breakage, a phenomenon known as replication catastrophe. However, the mechanism by which unprotected ssDNA breaks remains unclear. Here, we reveal that APOBEC3B is the key enzyme targeting unprotected ssDNA at replication forks, initiating a reaction cascade that induces fork collapse and poly(ADP-ribose) polymerase 1 (PARP1) hyperactivation. Mechanistically, we demonstrate that uracils generated by APOBEC3B at replication forks are removed by UNG2, resulting in abasic sites that are …

History’S Unsung Hero: Examining Oscar Dunn And African American History Through A Graphical Novel, Nefertari Yancie

The Councilor: A National Journal of the Social Studies

Social studies curriculum is at the center of heated debates in U. S. politics. Conservative politicians seek to limit what student are taught about the experiences of people of color who have been oppressed or subjected to racist policies and treatment throughout American history. Whitewashing history denies students the chance to examine history in its fullness as they are unable to analyze the voices and experiences of all people whose stories have contributed to the American story. In this article, the author explores how graphic novels may be used to teach African American history. Specifically, the author discusses how activities …

An Injury Healing On The Carapace Of Hottentotta Saulcyi (Simon, 1880) (Scorpiones: Buthidae), Fatih Yeşilyurt, Ersen A. Yağmur

Euscorpius

A new case of injury healing on the carapace is reported in a female Hottentotta saulcyi (Simon, 1880). An asymmetrical indentation was observed on the anterior part of the carapace, resulting from the healing of an old injury. The indentation is relatively deep, with muscle tissue visible inside it. Scar tissue is present at the end of indentation and healing tissue is present along its margins.

Leaders, Not Dictators: Why A Free Nation Starts With A Free People, Ahren Kirschbaum

Research Days

My poster explains the commonality between treacherous leaders of history, connecting it to the events in the White House today. The three leaders I analyzed, being Ronald Reagan, Napoleon and Stalin, all debased freedom of speech and media to further their goals. Reagan repealed the Fairness Doctrine, a bill that ensured unbiased news on radio and TV. The resulting news sources, such as FOX news, split the nation in half based on political ideology. In the bias and confusion, Reagan set up the government to favor the one percent through trickle down economics. In France, Napoleon entered power while the …

Political Philosophers Shaping Modern America, Sean O'Brien

Research Days

The research finds that John Locke and his contractarianist philosophies have been more influential in shaping the 21st-century America of today. John Stuart Mill’s philosophies of liberalism have not come to fruition throughout history as much as Locke's. Mill believes at the time of his work, liberalism is a political ideology that happens to be more utilitarian. Over time, America has changed to believe in liberalism, which does not draw as much inspiration from his work. It is his utilitarian philosophy that would reject 21st-century America and the way that it has formed over time. He simply believes in fundamental …

An Analysis Of Injury Surveillance Data At Division I Field Hockey With Implications For Practice And Treatment, Kathryn Evans

Liberty University Research Week

This study aims to investigate the injury prevenance data at Liberty University’s Division I NCAA field hockey team. Injuries are bound to occur during sport, and with the growing popularity of field hockey, it is crucial to recognize the pathologies that are most prevalent. In recent literature, concussion or mild traumatic brain injuries have been the most ubiquitous in this population. Falling close behind are ankle sprains. This study addresses the question: “What are the most prevalent injury in the last five years at Liberty Field Hockey?” Using the software Vivature, an electronic medical records system and ensuring the names …

Enhancing Animal Shelter Operations With Time Series And Machine Learning, Sakava L. Kiv, Donald L. Anderson, Shivam Negi, Jacquelyn Cheun

SMU Data Science Review

Enhancing animal shelter operations through machine learning involves employing a variety of advanced techniques aimed at increasing efficiency, promoting animal welfare, and optimizing resource allocation. This paper explores predictive analytics for adoption rates using regression models to estimate the likelihood of adoption based on historical data, encompassing variables such as breed, health status, and previous adoption trends. Additionally, classification algorithms are utilized to categorize animals by adoption probability, facilitating better resources and marketing prioritization. Clustering algorithms are employed to group animals according to behavior patterns and/or physical health, enabling tailored medical care and enrichment activities that improve their mental and …

Enhancing Network Security Through Dual-Layer Log Analysis: Integrating Machine Learning Classifiers With Large Language Models For Intelligent Anomaly Detection, Anthony Burton-Cordova, O'Neil Gray, Mohammad Al Rousan

SMU Data Science Review

This paper presents an innovative approach to enhancing network security by integrating machine learning algorithms with fine-tuned large language models (LLMs) to provide an expert assistant querying. The proposed method utilizes machine learning for efficient preprocessing and feature extraction from log data, followed by the application of a fine-tuned LLM to analyze and interpret anomalies with greater accuracy. This dual-layer detection system is designed to improve the identification of subtle and sophisticated security threats. The research team’s extensive evaluation using real-world log datasets indicates that the combined approach increases detection rates and communicates results in an understandable manner, demonstrating its …

The Tax Adviser, Volume 17, Number 2, February 1986 [Whole Issue], American Institute Of Certified Public Accountants

Tax Adviser

No abstract provided.

Tax Trends, Nicholas J. Fiore

Tax Adviser

No abstract provided.

Trade Or Business Status: Recent Judicial Interpretations, Daniel M. Slattery, Susan Nordhauser

Tax Adviser

No abstract provided.

Post-Reconstruction Sec. 367: New Rules And New Dangers, Wesley Yang, Davis W. Nelson

Tax Adviser

No abstract provided.

Tax Clinic, Thomas Ochsenschlager

Tax Adviser

No abstract provided.

Disclaimers As Premortem And Postmortem Estate Planning Tools, Travis P. Goggans, Michael R. Harmon

Tax Adviser

No abstract provided.

Analysis Of The Reverse Triangular Merger Regulations, Robert Willens

Tax Adviser

No abstract provided.

Tipped Out: Would Ending Involvement In The Flsa Tip Credit System Improve Georgia’S Restaurant Wages?, Zach Ayer

Georgia State University Law Review

The Tip Credit provision of the Fair Labor Standards Act (FLSA) allows a restaurant employer to pay a tipped employee just $2.13 per hour if the employee earns enough in tips to raise their hourly rate to the minimum wage. Enacted in 1966, the provision intends for restaurants, an industry group known for high costs and low profit margins, to employ tipped serving staff at lower cost while ensuring the tipped employees can still earn a competitive wage. The tipping system is not without issues, however. Many of the employers’ duties under the FLSA are difficult to account for, leading …

A Broken Record: A Statutory Solution To Fixing Music Copyright Infringement’S Biggest Problem, Jacob B. Hopkins

Georgia State University Law Review

In the intellectual property space, nothing quite grabs the eye of the public like music copyright infringement. The high reputational and monetary risks associated when an artist claims infringement— especially against that of a major artist—can have huge consequences, even when no infringement occurred. The two prevailing tests for copyright infringement recognize that the hearing court can determine there is not an appropriate level of substantial similarity between two copyrightable works, however this determination relies on specialized musical knowledge, something that the typical trial judge does not possess.

This Note examines the inefficiencies in our current scheme of music copyright …

Is Discrimination Unfair?, Jeff Sovern

Georgia State University Law Review

Though multiple federal laws explicitly bar discrimination in consumer transactions, many consumer transactions fall in the gaps between those laws. But recently, the Consumer Financial Protection Bureau (CFPB) and Federal Trade Commission (FTC) have attempted to plug those gaps on the theory that discrimination is unfair within the meaning of statutes they enforce prohibiting unfair practices (UDAAP statutes). Angered by this view, the U.S. Chamber of Commerce, joined by various banking trade groups, sued the CFPB in a federal court in Texas and persuaded a conservative judge to invalidate the Bureau’s interpretation. An appeal from the decision is pending.

But, …

A Legislative Foundation For Foundation Models, Steven Arango

Georgia State University Law Review

Artificial Intelligence (AI) is not some futuristic technology—it exists in everyday products like your Uber app or the Siri voice on your nightstand. Its development is meteoric; foundation models are the latest AI advancement. These models are a type of AI that not only produces a range of products but is also integrated into other AI models. This AI Swiss army knife is proving to be an incredible asset for economic development and national security. But, like other world- altering technology, there is a pernicious side of foundation models. Their flexibility offers adversaries, such as state and non-state actors, the …

Performance Optimization For Distributed Computing Via Gen Ai, Mingji Lou, Maksat Abasov, Fangfang Fu, Pragya Prakash, Venkata Siva Sai Manepalli

Defensive Publications Series

Methods, systems, and computer program products for performance optimization of distributed computing resources using generative artificial intelligence (AI) are provided. An example method may include receiving data associated with performance metrics of a distributed computing system and data associated with a cost function for activities engaged in with the distributed computing system. The method may include providing, as an input to a generative AI algorithm, the data associated with performance metrics of the distributed computing system, the data associated with a cost function for activities engaged in with the distributed computing system, and data associated with a knowledge graph regarding …

We Are Our Brains: Disembodied Brain Films In 1950s Cold War America, David P. Pierson

Faculty, Staff, and Alumni Books

Personified Body Parts in Cinema, Literature, and Visual Culture investigates the power of personifying body parts in cinema, television, visual culture, literature, erotica, folklore, and mystique.

Culturally, socially, and poetically exposing hidden aspects and subtleties of human existentialism, this book vigorously questions and problematizes numerous artistic, aesthetic, technological, naïve, and macabre manipulations of body parts for various purposes. A diverse team of authors explore how scribing human traits to limbs, eyes, brains, genitalia, hearts, and other inner organs is grotesque and aesthetic, repealing and appealing, intimidating and intimate, rude and enjoyable, material and spiritual, surprising and mundane. Personified organs are …

In Re: Gabriel Bravo

2025 Decisions

USDC for the Eastern District of Pennsylvania

Analyzing The Drivers Of Airline Profitability, Brady Noble

Honors Theses

The commercial aviation industry, despite its transformative impact on global connection and economy, has historically struggled with consistent profitability. This thesis investigates the drivers of financial success within the airline industry, with a particular focus on the relationship between passenger load factors and profitability. Passenger load factors, defined as the percentage of available seats occupied by paying customers, have emerged as a key performance indicator, offering important insights into operational efficiency and revenue generation.

The study utilizes comprehensive data from the Bureau of Transportation Statistics, encompassing quarterly metrics on revenue, load factors, operating costs, and fuel prices from 2002 to …