Digital Commons Network^™

The Effects Of Cigarette Smoke Extract On Osteoarthritis In A Primary Joint Tissue Explant Model, Emily Sawvell

All Dissertations

Osteoarthritis (OA) is the most common degenerative joint disease in the world with an economic burden of nearly $140 billion annually. Factors identified to increase the risk of developing OA include age, obesity, sex, race, genetics, and previous joint injury. However, one risk factor that has been scarcely studied in OA etiology is cigarette smoking. While some studies have reported smoking to protect against OA, increasing evidence suggests that cigarette smoking results in more severe and painful OA, increases the rate of developing OA, and reduces the efficacy of pain medications and arthritis-targeting therapies. Despite this, the impact of cigarette …

A Stakeholder-Informed Conceptual Framework For Evaluating Genomics In Precision Oncology, Julie A. Wiedower

All Dissertations

This dissertation explores the value of genomic testing in precision oncology with an emphasis on how US payers conceptualize and prioritize elements of value. This research aims to address gaps in understanding payer perspectives and proposes a stakeholder-informed framework for evaluating genomic testing in oncology. To achieve this aim, the presented research investigates payer perspectives, value-based cancer care priorities, and the conceptual understanding of the value of a genetic diagnosis to establish a framework for value with the payer audience in mind. Chapter 1 outlines relevant background information relating to the genomic revolution and challenges in translating genomic testing technologies …

Probing The 'Mev Gap': Discovery And Characterization Of Persistent And Transient Mev-Gev Gamma-Ray Sources With The Fermi Large Area Telescoope, Scott Joffre

All Dissertations

The MeV Gap is a moniker for the energy regime E~0.1-100 MeV that has lacked sensitive observations for the last 20 years. This is not out of scientific disinterest, but observational challenges. The only instrument currently available to make observations in the MeV Gap is the Fermi Large Area Telescope (LAT). For the first time ever, Fermi-LAT has been leveraged to push its observational capabilities to its absolute lower energy limit to end this 20-year observational gap. Observing the MeV sky is imperative for identifying some of the most luminous galaxies in the Universe known as blazars. The brightest blazars …

Deciphering And Translating Bioinspired Structures For Engineering Materials Design Via Computational Modeling And Machine Learning, Zhangke Yang

All Dissertations

Nature has evolved extraordinary structural materials—such as nacre, bone, and the mantis shrimp’s dactyl club—that achieve remarkable combinations of strength, toughness, and impact resistance. These properties arise from sophisticated synergies between structure and composition. Inspired by these biological systems, this dissertation presents a comprehensive investigation into bioinspired materials, uncovering fundamental mechanisms and providing guidance on designing materials with superior mechanical properties.

This dissertation begins by examining the "brick-and-mortar" structure of nacre, which informs the design of layered polymer-graphene nanocomposite films. Using coarse-grained molecular dynamics simulations, I elucidate mechanisms of dynamic wave propagation and energy dissipation in these systems, providing critical …

Defining, Defending, & Delusion: White Social Studies Teachers Grappling With Whiteness, Meghan E. Moore-Hubbard

All Dissertations

This study explores rural white social studies teachers’ understandings of their whiteness and racial identity. In this multiple-case study, four participants engaged with a reader designed to elicit discussion and reflection on whiteness. Over the course of one week, teachers read works by George Lipsitz, Reverend Thandeka, Charles W. Mills, and James Baldwin. Grounded in the work of these scholars and the theory of Critical Whiteness Studies, this study asked participants to reflect on, discuss, and design lesson plans to be implemented in their classrooms based on their understanding of whiteness. Data was gathered in the form of interviews, reader …

Serious Leisure, Passion, And Burnout, Carson Matsick

All Dissertations

This study examined the relationships between aspects of serious leisure, dualistic passion, and burnout in the MBI-GS and BM. Serious leisure has been shown to improve leisure and general life outcomes, but little research considers how harmonious or obsessive leisure engagement affects these outcomes or has extended serious leisure benefits to the workplace. Overall, the study hypothesized that leisure seriousness, harmonious passion, and satisfaction with time spent in serious leisure will negatively correlate with burnout, and obsessive passion will degrade the benefits derived from serious leisure. 240 participants completed Gould's Serious Leisure Inventory, the Passion Scale, the Maslach Burnout Inventory …

The Effect Of Nuclear Isomers On S-Process Nucleosynthesis, Jaad Tannous

All Dissertations

s-Process nucleosynthesis is a process in which stars produce elements of mass range A = 57 to 210. Since the days of B2FH, immense work has gone into quantifying and computing s-process yields and pathways. We expand upon said work along two fronts. The first front sets up the framework for proper treatment of nuclear isomers in network calculations. We apply the framework to study 85Kr, which is a pivotal isotope in the s-process chain that affects the abundance yields of Strontium and Rubidium isotopes. In particular, we are interested in the ratio of 88Sr/86Sr and 87Rb which are important …

Bridging The Gap In Rural Education: Exploring Solutions For Enhanced College And Career Preparedness Among Secondary School Students, Patricia Moultrie-Goldsmith

All Dissertations

This study investigates how to improve college and career readiness (CCR) among high school students in rural areas. The study focuses on creating effective strategies that cater specifically to the unique needs of rural students. Using a blend of both quantitative and qualitative research methods, the study examines the effectiveness of specific interventions designed to raise students' readiness for college and careers.

The interventions tested include teaching methods and increased engagement with students. These were developed to tackle the common challenges that hinder educational outcomes in rural settings, such as limited access to advanced courses and extracurricular activities.

Findings from …

Borders And Burdens: Three Essays On Inter-Jurisdictional Tax Policy In America, Benjamin Jaros

All Dissertations

Individuals, firms, and governments make decisions about the tradeoffs of different tax policies at jurisdictional borders, such as those between states, nations, or local governments; those choices shape the burden of taxation. This dissertation examines the effects of three distinct changes in tax policy: for state corporate income tax apportionment, colonial tobacco tariffs, and tax abatements for data centers. Chapter 1 examines how changes to the corporate income tax base formula affect state tax revenues. Chapter 2 analyzes how colonial era export and import tariffs on tobacco impacted trade volumes, raised revenue, and the distribution of the tax burden between …

Essays On Worker Skills And The Black-White Male Unemployment Gap In The United States, Srijan Banerjee

All Dissertations

This dissertation is composed of two chapters examining how differences in experience and skill development, over the life-cycle of workers, shape the unemployment gap between black and white male workers in the United States. Understanding these mechanisms is crucial since the black-white unemployment gap remains a persistent feature of the US labor market across the past several decades.

In the first chapter, I study the impact of differences in life-cycle skill development on the black-white unemployment gap for high-school-educated male workers. Using a shift-share framework, I document the inability of differences in labor composition across observable characteristics such as education, …

Amyloid Aggregation And Mitigation, Zhenzhen Zhang

All Dissertations

The buildup of protein in tissues and organs plays a major role in unfunctional several serious diseases, including Alzheimer’s disease, Parkinson’s disease, and Type 2 diabetes, each tied to specific proteins that form harmful amyloid deposits. Amyloid aggregation typically follows a sigmoidal kinetic curve, beginning with a slow lag phase, followed by rapid fibril growth, and eventually reaching a plateau where mature, stable fibrils are formed. However, the early stage of aggregation remains particularly difficult to capture experimentally due to the highly dynamic nature and low abundance of small oligomeric species. In this dissertation, we employed discrete molecular dynamics (DMD) …

An Investigation Of Design Processes And Their Effects On Accessibility In Narrative Themed Environments, Arielle Spencer

All Dissertations

Accessibility matters, and not merely in meeting minimum codes or limited to basic necessities. Access and inclusion matter still more in places of recreation and leisure which have too often been overlooked or considered low priority, however it is precisely these places that merit special attention. Narrative Themed Environments occupy a unique position relative to the general built environment, often acting as utopic ‘other-spaces’ for enjoyment, freedom, and escape. However, for guests with disabilities, current themed experiences can often lack true inclusivity and instead create inequality, segregation, diminished experiences, and feelings of isolation and exclusion. The peculiar idiosyncratic design process …

From Epithelium To Therapy: Transitional Cells In Lung Fibrosis, Sarah Y Shin, Jichao Chen, Irit Milman Krentsis, Yair Reisner, Rodeo Abrencillo, Danielle Wu

Faculty, Staff and Student Publications

Patients with idiopathic pulmonary fibrosis and lung fibrosis secondary to infections such as influenza A and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have limited treatment options outside of supportive therapy and lung transplantation. Multiple lung stem cell populations have been implicated in the pathogenesis of lung fibrosis, and more progenitor cell populations continue to be discovered and characterized. In this review, we summarize the functions and differentiation pathways of various cells that constitute the lung epithelium. We then focus on two subpopulations of KRT5

A Biomarker Signature-Guided Clinical Trial Design For Precision Medicine, Yuan Li, Dejian Lai, Ruosha Li, Han Chen, Xuelin Huang

Faculty, Staff and Student Publications

Targeted cancer therapies aim to effectively treat patients with specific biomarker profiles. Nevertheless, these therapies may not always precisely hit their intended targets, leading to uncertainty about the specific subset of patients who will benefit. To address this uncertainty, the identification of sensitive patient subsets in clinical trials becomes crucial. Our proposed phase IIB/III clinical trial design seeks to pinpoint a biomarker signature with precision, ensuring the accurate identification of patients who will respond to a specific treatment. This approach allows for the selective enrollment of sensitive patients to maximize benefits for trial participants. We incorporate Bayesian methodology to facilitate …

Case: Pituitary Mass In A Pediatric Patient, Alyssa Baldini, Carla Calvo

Rowan-Virtua Research Day

We report a case of a 16-year-old female presented to the pediatric emergency department for intermittent visual disturbance and was diagnosed with a pituitary mass resulting in episodic complete bilateral vision loss. Pediatric neurologic complaints can be challenging for a number of reasons. It is important as much as possible to obtain a detailed history from the patient and parent, conduct a relevant chart review, and identify if there have been any recent medication changes. Seeking expert consultation may also be helpful in establishing a diagnosis.

Carbon Footprint Of Inhaled Anesthetics – Do The Risks Outweigh The Benefits?, Liam Kerrick, Joseph Moschella

Rowan-Virtua Research Day

Global warming presents many challenges to the healthcare system. Not only does the increasing global temperature have detrimental health effects itself, but the healthcare sector is also a huge contributor to global warming. One big contributor to global warming is the use of inhaled anesthetics, which possess global warming potentials up to 2,000 times greater than carbon dioxide. Recent proposals, such as a prospective ban of desflurane in 2026 by the European Commission, demonstrate the need to reevaluate many of the common practices within anesthesiology. This review looks to investigate the environmental impact, cost, and clinical efficacy of various anesthetic …

Evaluation Of Human Mesenchymal Stromal Cells (Msc) As An Adjuvant Therapeutic For Chronic Lyme Disease, Matthew Teryek

Rowan-Virtua Research Day

Background: Lyme disease, caused by the spirochetal bacterium Borrelia burgdorferi, is the most prevalent vector-borne illness in the Northern Hemisphere. If undiagnosed or untreated, the disease progresses through multiple stages of increasing clinical severity. While antibiotics such as doxycycline and ceftriaxone are the current standard of care, patients with chronic or late-stage Lyme disease may require additional therapeutic interventions.

Rationale: Human mesenchymal stem cells (MSCs) are of growing clinical interest due to their immunomodulatory properties, low immunogenicity, and potential to promote tissue repair. These characteristics position MSCs as promising adjuvant therapies for chronic Lyme disease, with the potential to …

Chd1 Loss Reprograms Srebp2-Driven Cholesterol Synthesis To Fuel Androgen-Responsive Growth And Castration Resistance In Spop-Mutated Prostate Tumors, Feiyu Chen, Haoyan Li, Yin Wang, Ximing Tang, Kevin Lin, Chenling Meng, Javier Leo, Xin Liang, Jie Zhang, Vivien Van, Iqbal Mahmud, Bo Wei, Philip L Lorenzi, Maria G Raso, Ana Aparicio, Yue Lu, Daniel E Frigo, Boyi Gan, Di Zhao

Faculty, Staff and Student Publications

Despite undergoing castration, most individuals with prostate cancer (PCa) experience progression to castration-resistant PCa (CRPC), in which the androgen receptor (AR) remains an important driver. Concurrent genetic alterations in SPOP and CHD1 define a unique subtype of PCa, but their interactions in tumor progression and therapy response remain unclear. Here, we provide genetic evidence supporting that CHD1 loss accelerates disease progression and confers resistance to castration in males with SPOP-mutated PCa. By leveraging genetic engineering and multiomics, we uncovered a noncanonical function of CHD1 in lipid metabolism reprogramming via repressing the SREBP2 transcriptome. Loss of CHD1 induces cholesterol production, supplies …

Treatment Of C-Met Antibody-Drug Conjugate Asymptomatic Pneumonitis With A Novel Steroid Regimen In Non-Small Cell Lung Cancer: A Case Report, Daniel A Fox, Christine Tran, Vincent Blot, David S Hong

Faculty, Staff and Student Publications

Antibody-drug conjugates (ADCs) are a potent class of antineoplastic drugs that deliver cytotoxic agents via targeting with monoclonal antibodies; however, ADCs are associated with high rates of lung toxicities, limiting the therapeutic potential in many patients. We report a case of a patient with metastatic non-small cell lung cancer taking the ADC telisotuzumab vedotin (Teliso V) plus osimtertinib who developed ADC-induced pneumonitis despite clinical benefit. This patient was able to tolerate treatment for a prolonged period on a novel steroid regimen, using steroids when pneumonitis was asymptomatic but radiologically evident and as a daily suppressant. This treatment strategy may have …

Interplay Between Skeletal Muscle Catabolism And Remodeling Of Arteriovenous Fistula By Yes-Associated Protein 1 (Yap1) Signaling, Yongdong Wu, Tae Hoon Lee, Owen H Cheng, Eric K Peden, Qingtian Li, Jun Wang, Fengzhang Huang, Marites P Melancon, David Sheikh-Hamad, Tao Wang, Luan Truong, William E Mitch, Ming Liang, Jizhong Cheng

Faculty, Staff and Student Publications

Key Points:

1. Atrophied muscle–derived myostatin stimulated mesenchymal stem cell differentiation and adverse arteriovenous (AV) fistula remodeling through yes-associated protein 1 (YAP1) activation.

2. Treatment with myostatin peptibody inhibited muscle wasting and blocked mesenchymal stem cell activation and AV fistula fibrosis.

3. A light-sensitive drug-release strategy was engineered for the periadventitial delivery of verteporfin to improve AV fistula patency.

Background: Arteriovenous (AV) fistulas are the preferred access for dialysis but have a high incidence of failure. The aim of this study was to understand the crosstalk between skeletal muscle catabolism and AV fistula maturation failure.

Methods: Skeletal muscle metabolism and AV fistula maturation …

Pathobiology Of Aortic Aneurysms And Dissections: Synthesis Of Recent Investigations And Evolving Insights, Navneet Narula

Faculty, Staff and Student Publications

The pathobiology of aortic disease is linked to aortic region: atherosclerosis for abdominal aorta, primary medial degeneration or aortitis for ascending thoracic aorta, and all causes for descending thoracic aorta and thoracoabdominal lesions. The pathogenesis of aortic dissection involves damage of the outer media from impaired perfusion from dysfunctional vasa vasorum, formation of discrete foci of disrupted vascular smooth muscle cell-elastic fiber extension-contractile units, and imbalance of radial sheer stress across the aortic wall, thereby creating an intimal tear and linear dissection. Thoracic aortic aneurysms develop from the chronic progression of medial degeneration coupled with the weakening of the remodeled …

Kinasefusiondb: An Integrative Knowledge Of Kinase Fusion Proteins In Multi-Scales, Leonardo Aguilar, Pora Kim

Faculty, Staff and Student Publications

Kinase fusion genes were the most targeted fusion gene group among multiple major cellular gene groups. Kinase inhibitors disrupt aberrant signaling cascades and inhibit tumor progression, yet the specific mechanisms of action of the U.S. Food and Drug Administration (FDA)-approved inhibitors in the context of kinase fusion oncoproteins remain largely unknown. This gap limits our ability to develop personalized therapies and next-generation kinase inhibitors. To address this, we developed a novel in silico pipeline for predicting 3D structures of kinase fusion proteins and performing structure-based virtual screening. This approach enables large-scale structural annotation and drug screening across pan-cancer kinase fusions. …

Navigating Insulin Access For Pediatric Type 1 Diabetes: Caregivers' Experiences And Challenges, Ella Anderson

Doctoral Dissertations

Between 2012 and 2018, the annual 14% increase in insulin prices made Type 1 Diabetes (T1D) the most expensive chronic health condition, significantly raising out-of-pocket costs for uninsured or underinsured individuals in the United States (Hayes & Farmer, 2020; Willner et al., 2020). This study utilized a qualitative content analysis methodology to explore the challenges and experiences of parents with children diagnosed with T1D with accessing insulin for their child. Five participants from various areas of the United States responded to open-ended questions both in person and via Zoom. The analysis revealed three main themes: pragmatics of managing diabetic care, …

Robust Statistical Techniques For Operational Maintenance Of The 10.7 Cm Solar Radio Flux, Daniel A. Brandt, Erick F. Vega, Brian Thelen

Michigan Tech Publications

The F10.7 solar radio flux is a critical quantity for operational space weather nowcasting and forecasting, where it is routinely used as a driver for coupled atmospheric models to estimate a variety of important quantities such as the neutral atmospheric density. Although there have been several successful developments in the way of parametric modeling to ensure F10.7 coverage during outages (often using the sunspot number or radio flux observations at neighboring wavelengths), these developments have refrained from employing comprehensive cross-validation schemes to ensure model generalizability, and can benefit from recently-developed techniques for modeling nonlinear phenomena. We present an approach that …

Search For A Diffuse Flux Of Photons With Energies Above Tens Of Pev At The Pierre Auger Observatory, A. Abdul Halim, P. P. Abreu, M. Aglietta, I. Allekotte, K. Almeida Cheminant, A. Almela, B. Fick, K. Nguyen, D. Nitz, Et Al.

Michigan Tech Publications

Diffuse photons of energy above 0.1 PeV, produced through the interactions between cosmic rays and either interstellar matter or background radiation fields, are powerful tracers of the distribution of cosmic rays in the Galaxy. Furthermore, the measurement of a diffuse photon flux would be an important probe to test models of super-heavy dark matter decaying into gamma-rays. In this work, we search for a diffuse photon flux in the energy range between 50 PeV and 200 PeV using data from the Pierre Auger Observatory. For the first time, we combine the air-shower measurements from a 2 km2 surface array consisting …

How Can Coalitions Positively Impact Michigan’S Rural Communities And Influence Local Policies: A Comparative Case Study, Amanda Bonesteel-Kratt

Master of Public Administration Capstone Papers

This research explores the impact of coalitions on communities and their influence on local and state policies in rural agricultural communities in Michigan. Nonprofit organizations often utilize coalitions to strengthen their outreach efforts and impact, and in this paper, the author focuses on Farm-to-Power (FTP), a new nonprofit organization in Michigan. FTP advocates for landowners’ rights regarding renewable energy, specifically wind and solar, on a utility scale. This paper explores the best practices concerning effective coalition-building that have the capability to impact policy changes that benefit farming communities through improved economic stability. Access to renewable energy leases for Michigan farmers …

“But Where Are Those Good Old-Fashioned Values?”—The Racial Politics Of Animated Satire In Family Guy, Jordanne Greenidge

Master's Theses

Few animated shows have shaped American pop culture quite like Family Guy. Known for its rapid-fire cutaway gags and irreverent humor, the series has remained a television mainstay since its debut in 1999, despite frequent criticism and even two cancellations. Created by Seth MacFarlane and based on his 1995 student film The Life of Larry, Family Guy has built its reputation on pushing the boundaries of taste, especially when it comes to race, gender, and politics. Though often defended as satire, the show’s use of racial humor raises questions about its true impact: Do its portrayals of Black characters challenge …

The Adirondack Frontier: Reclaiming A Vital Role In Shaping The Nation, Peter Nelson

Master's Theses

The traditional version of Adirondack history from the revolutionary period to the middle of the nineteenth century, which portrays the region as unexplored primeval wilderness, is nineteenth-century romantic mythology. It ignores thousands of years of Indigenous habitation and misrepresents early Euro-American activity in the region as well. In fact, from the earliest days of colonial exploration of North America until the middle of the 19th-Century, New York's Adirondack region was a dynamic American frontier, as important in shaping the destiny of the nation as the Northwest Territory or, later, the West. Activities in the Adirondack frontier contributed to the decimation …

Disambiguart: A Neural-Based Inference Model For Knowledge Graph Disambiguation, Budhitama Subagdja, D. Shanthoshigaa, Ah-Hwee Tan

Research Collection School Of Computing and Information Systems

One main challenge in constructing a knowledge graph (KG) is to deal with ambiguity. Specifically, an entity in the graph can be assigned with multiple meanings while two or more entities considered to have different meanings may actually be the same. Assigning an entity with the correct meaning may involve re-evaluation of its relevant contexts. This costly operation typically involves searching for other similar entities within the KG such that the context can be determined. In this paper, a new model called DisambiguART is proposed leveraging multi-channel matching and inference in a self-organizing neural network for sense disambiguation in knowledge …

Fixdrive: Automatically Repairing Autonomous Vehicle Driving Behaviour For $0.08 Per Violation, Yang Sun, Christopher M. Poskitt, Kun Wang, Jun Sun

Research Collection School Of Computing and Information Systems

Autonomous Vehicles (AVs) are advancing rapidly, with Level-4 AVs already operating in real-world conditions. Current AVs, however, still lag behind human drivers in adaptability and performance, often exhibiting overly conservative behaviours and occasionally violating traffic laws. Existing solutions, such as runtime enforcement, mitigate this by automatically repairing the AV's planned trajectory at runtime, but such approaches lack transparency and should be a measure of last resort. It would be preferable for AV repairs to generalise beyond specific incidents and to be interpretable for users. In this work, we propose FixDrive, a framework that analyses driving records from near-misses or law …