Expert Consensus For Key Components Of A High-Quality Ventral Hernia Repair Operative Note, Gina Adrales, Karla Bernardi, Anne P Ehlers, Hobart Harris, Julie Holihan, William Hope, Jeffrey E Janis, Michele Loor, Clayton Petro, Luke Putnam, Caroline E Reinke, John Scott Roth, Christopher Senkowski, Kendell Sowards, Shirin Towfigh, Daniel Dante Yeh, Zuhair Ali, Mike K Liang

Faculty, Staff and Students Publications

Background: Ventral hernia repair (VHR) is one of the most commonly performed procedures by surgeons; however, there remains a lack of consensus for key components of operative reporting. Prior literature has identified several key elements that are recommended for inclusion in ventral hernia repair operative notes, but it is unclear whether these details alone make for a high-quality operative note. This study sought to determine whether experts agree on what factors make a ventral hernia repair operative note high-quality.

Study design: A prospective exploratory sequential survey-based mixed-methods design was used for round 1. Conclusions via thematic analysis from survey responses …

Temporal Dynamics Of Bmp/Nodal Ratio Drive Tissue-Specific Gastrulation Morphogenesis, Cristian Coarfa, Nathan D Lord, Margot Kossmann Williams

Faculty, Staff and Students Publications

Anteroposterior elongation of the vertebrate body plan is driven by convergence and extension (C&E) gastrulation movements in both the mesoderm and neuroectoderm, but how or whether molecular regulation of C&E differs between tissues remains an open question. Using a zebrafish explant model of anteroposterior axis extension, we show that C&E of the neuroectoderm and mesoderm can be uncoupled ex vivo, and that morphogenesis of individual tissues results from distinct morphogen signaling dynamics. Using precise temporal manipulation of BMP and Nodal signaling, we identify a critical developmental window during which high or low BMP/Nodal ratios induce neuroectoderm- or mesoderm-driven C&E, respectively. …

The Impact Of Dwell Time On The Contextual Effect Of Visual And Passive Lead-In Movements, Laura Alvarez-Hidalgo, David W. Franklin, Ian S. Howard

School of Engineering, Computing and Mathematics

Contextual cues arising from distinct movements are crucial in shaping control strategies for human movement. Here, we examine the impact of visual and passive lead-in movement cues on unimanual motor learning, focusing on the influence of “dwell time,” where two-part movements are separated by the interval between the end of the first movement and the start of the second. We used a robotic manipulandum to implement a point-to-point interference task with switching opposing viscous curl fields in male and female human participants. Consistent with prior research, in both visual and passive lead-in conditions, participants showed significant adaptation to opposing dynamics …

Simulation And Feasibility Assessment Of A Green Hydrogen Supply Chain: A Case Study In Oman, Mi Tian, Shuya Zhong, Muayad Ahmed Mohsin Al Ghassani, Lars Johanning, Voicu Ion Sucala

School of Engineering, Computing and Mathematics

The transition to sustainable energy is crucial for mitigating climate change impacts. This study addresses this imperative by simulating a green hydrogen supply chain tailored for residential cooking in Oman. The supply chain encompasses solar energy production, underground storage, pipeline transportation, and residential application, aiming to curtail greenhouse gas emissions and reduce the levelized cost of hydrogen (LCOH). The simulation results suggest leveraging a robust 7 GW solar plant. Oman achieves an impressive annual production of 9.78 TWh of green hydrogen, equivalent to 147,808 tonnes of H₂, perfectly aligning with the ambitious goals of Oman Vision 2040. The …

Multi-Omic And Spatial Analysis Of Mouse Kidneys Highlights Sex-Specific Differences In Gene Regulation Across The Lifespan, Siqi Chen, Ruiyang Liu, Chia-Kuei Mo, Michael C Wendl, Andrew Houston, Preet Lal, Yanyan Zhao, Wagma Caravan, Andrew T Shinkle, Atieh Abedin-Do, Nataly Naser Al Deen, Kazuhito Sato, Xiang Li, André Luiz N Targino Da Costa, Yize Li, Alla Karpova, John M Herndon, Maxim N Artyomov, Joshua B Rubin, Sanjay Jain, Sheila A Stewart, Li Ding, Feng Chen, Et Al.

2020-Current year OA Pubs

There is a sex bias in the incidence and progression of many kidney diseases. To better understand such sexual dimorphism, we integrated data from six platforms, characterizing 76 kidney samples from 68 mice at six developmental and adult time points, creating a molecular atlas of the mouse kidney across the lifespan for both sexes. We show that proximal tubules have the most sex-biased differentially expressed genes emerging after 3 weeks of age and are associated with hormonal regulations. We reveal potential mechanisms involving both direct and indirect regulation by androgens and estrogens. Spatial profiling identifies distinct sex-biased spatial patterns in …

Administrative Law And The Pandemic, Gillian E. Metzger

Faculty Scholarship

American administrative law’s relationship to change is, as they say, compli­cated. On the one hand, continual evolution has been an endemic feature of American administrative law. Doctrines such as Chevron deference to agency statutory interpretations were born, grew, and declined in just the period from the 1980s to today. On the other, the United States (US) Supreme Court regularly rejects such common law development in administrative law as illegitimate and insists that federal judges must adhere to the original terms of the 1946 Administrative Procedure Act (APA) and other statutes, unless the Constitution requires otherwise. And to this day scholars …

Constraining The Family Regulation System: The Contribution Of The Restatement Of The Law, Children And The Law, Clare Huntington

Faculty Scholarship

Advocates, policymakers, and scholars have argued for years that the family regulation system (also known as the child welfare system) fails families. Critics rightly note that the system does far too little to support families proactively and does not address the poverty and structural racism underlying many allegations of child abuse and neglect. The overrepresentation of Black, Native American, and Native Alaskan children in foster care is a stark and disturbing manifestation of these failings.

In response to these concerns, there is an active debate about abolishing or radically reforming the family regulation system to direct government funding to proactive …

Restating The Law Of Children And Youth: The Evolution Of Reform, Elizabeth S. Scott

Faculty Scholarship

A brief roadmap of this article may be helpful. Part I describes the emergence of the Child Wellbeing framework and its powerful role in shaping twenty-first-century youth justice reforms captured by the Restatement. Part II shows how this framework has begun to have a far broader influence on the law affecting children and how the framework and the developmental approach embodied in the Restatement can guide courts and shape the trajectory of the law in the future. Part III explores potential challenges to the Restatement’s effectiveness in attaining a fully integrated system based on the Child Wellbeing framework.

Rural High-School Principals’ Perceptions Of Their Understanding Of Special Education Law, Tiffany Jenkins

Electronic Theses and Dissertations

This phenomenological study aimed to determine rural high school principals’ perceptions of their understanding of special education law. Although there is some literature regarding administrators' perceptions of their understanding of special education policies and procedures, this study focused specifically on special education law and perceived versus actual levels of understanding.

Data Collection strategies include voluntary, focused interviews of rural high school principals via Zoom. Data analysis included transcriptions of interviews, member checking, open coding, identifying themes and content analysis, and finally, interpretation and triangulation of the data. The analysis of this study was based on the theoretical proposition of andragogy. …

Brand Media And Health Perceptions: A Thematic Analysis Of Generational Differences, Julie Irene Diaz

Electronic Theses and Dissertations

This thesis explores the influence of brand identity and media on shaping evolving perceptions of health across generations. The three generations considered are Generation X, Millennials, and Generation Z. The initial hypothesis predicted the popular media and brands that each generation interacts with are most likely to influence their perception. Additionally, the health brands most popular with each generation would influence their overall health perception, based on the identity and values of the brand. A qualitative study was conducted using focus groups to gather data about health perceptions, brand identity, media influence, and holistic health. The findings suggest that individuals …

Innovating Professional Learning: A Design Thinking Approach To Pk-12 Education Development, Shanna Hensley

Electronic Theses and Dissertations

The increasing complexity of 21^st century education has heightened the demand for professional development (PD) that effectively support educators in adapting to evolving standards and diverse student needs. Despite extensive investment in PD, significant gaps remain in its design, implementation, and evaluation, often leading to ineffective outcomes. This qualitative, phenomenological study explored the processes involved in identifying, developing, implementing, and evaluating professional learning programs in PK-12 education, with the goal of identifying key factors that contribute to their effectiveness. Grounded in the design thinking framework, this study employs five phases: empathy, define, ideate, prototype, and test, to investigate how …

Mathematics Outcomes For Career And Technical Students Enrolled At A Community College In East Tennessee, Malissa Trent

Electronic Theses and Dissertations

The primary purpose of this study was to compare the success of college-ready and academically underprepared community college students in a college-level math course designed for career and technical programs. A non-experimental two-group comparative design with existing data examined differences in academic metrics based on participation in a corequisite learning support mathematics course. The study used a sample size of 1070 students from a community college in East Tennessee who were enrolled in a college-level Trigonometric Applications course between the fall of 2015 and the spring of 2024. Due to a lack of prior academic preparation, 500 of these students …

Inferring Feeding Biology In Extinct Shrews (Soricidae: Mammalia): Application Of A Linear Morphometric Approach, Derek J. Den Ouden

Electronic Theses and Dissertations

Linear morphometrics have been used extensively to infer the ecology of fossil organisms, but shrews have not yet been thoroughly explored using this technique. Often considered to have a homogenous insectivorous diet, direct dietary observation suggests shrew dietary diversity is substantial. Diversity of this nature is well established to have influenced skull morphology in other mammal clades, so similar patterns are hypothesized to be detectable in shrews. To test this, I examined the link between known diet and morphological disparity in extant shrews using linear morphometrics and then utilized that framework to infer the dietary ecology of several fossil taxa. …

Metastatic Medulloblastoma Remodels The Local Leptomeningeal Microenvironment To Promote Further Metastatic Colonization And Growth, Alexander Bahcheli, Randy Van Ommeren, Kyle Juraschka, Maria Vladoiu, Winnie Ong, Bryn Livingston, Pasqualino De Antonellis, Michelle Ly, Borja López Holgado, Olga Sirbu, Shahrzad Bahrampour, Hyun-Kee Min, Jerry Fan, Carolina Nor, Abhirami Visvanathan, Jiao Zhang, Hao Wang, Lei Qin, Ning Huang, Jonelle Pallotta, Tajana Douglas, Esta Mak, Haipeng Su, Karen Ng, Kevin Yang Zhang, Craig Daniels, Calixto-Hope G Lucas, Charles G Eberhart, Hailong Liu, Tao Jiang, Faiyaz Notta, Vijay Ramaswamy, Jüri Reimand, Marco Gallo, Jeremy N Rich, Xiaochong Wu, Xi Huang, Michael D Taylor

Faculty, Staff and Students Publications

Leptomeningeal metastases are the major source of morbidity and mortality for patients with medulloblastoma. The biology of the leptomeningeal metastases and the local tumour microenvironment are poorly characterized. Here we show that metastasis-associated meningeal fibroblasts (MB-MAFs) are transcriptionally distinct and signal extensively to tumour cells and the tumour microenvironment. Metastatic cells secrete platelet-derived growth factor (PDGF) ligands into the local microenvironment to chemotactically recruit meningeal fibroblasts. Meningeal fibroblasts are reprogrammed to become MB-MAFs, expressing distinct transcriptomes and secretomes, including bone morphogenetic proteins. Active bone morphogenetic protein signalling and co-implantation of tumour cells with MB-MAFs enhances the colonization of the leptomeninges …

Sacred Connections In Cartoonish Places: Exploring The Implications Of Teotl In Avatar: The Last Airbender (2008), Makenzie P. Morrison

Electronic Theses and Dissertations

Taking Avatar: The Last Airbender (2008) seriously, Sacred Connections in Cartoonish Places explores the animated children’s series and how it is understood through the monistic Nahua (Aztec) concept of teotl. Relying on James Maffie’s text Aztec Philosophy: Understanding a World in Motion (2014), this thesis determines that Avatar: The Last Airbender benefits from monistic analysis. This analysis results in a breakdown of the show into four body chapters. These chapters respectively explore Aang’s role as a monistic representative, the differences between the physical and spirit worlds presented in the show, the kind of relationships that appear in the series, and …

Structuring The Sustainability Of Happiness In Critical Postmodernity: A Metadata, Mixed-Methods Study In Education, Roxanne Renee Rodriguez

Open Access Theses & Dissertations

This dissertation study is built upon a pilot study that uses a meta-theoretical analysis on the culture of education. The purpose of it is to examine [un]happiness, a phenomenon influenced by the social, political, and economic systems in Western paradigms within a critical postmodern view, looking at the intricacies of schooling, as no studies have taken a bottom-up approach to investigate the voices of the main stakeholders: students, teachers, and administrators. My study questions whether a holistic, liberating, and socially responsive curriculum could engender a positive learning environment wherein happiness is sustainable. Within happiness studies, hope is essential, so much …

Investigating The Impact Of Bilingual Experience And Language Use Context On Cognitive Control In An Auditory Stroop Task, Christian Ruiz-Ortiz

Open Access Theses & Dissertations

Bilinguals are often reported to outperform monolinguals on executive control tasks, yet recent work suggests that any bilingual adaptations depend on how, and in which contexts, individuals use their two languages. The present dissertation tested whether specific dimensions of bilingual experiences (proficiency balance and daily interaction situations) predict the way listeners engage proactive (anticipatory) versus reactive (stimulus-driven) control when resolving non-linguistic conflict. Sixty young adults completed a non-linguistic auditory Stroop task that manipulated conflict expectancy both list-wide and item-specifically. Group-level analysis replicated classic proportion-congruency effects, but not the predicted proactive control signature, and transfer cost indexing reactive control was not …

Impact Of Magnetic Fields On Cosmic Ray Density In Molecular Clouds, Byron Jesus Encinas Velazquez

Open Access Theses & Dissertations

We investigate the effects caused by Cosmic Rays (CRs) in a Molecular Clouds (MCs) environment and the effects of varied magnetic field configurations in the core (r = 1 Pc ) of a MC. We take as initial conditions for the interstellar medium a product of various supernova explosions as injected initial perturbation and observe the evolution during the timescale of ~4.5 Myrs. We compute the CR reduction factor R as a measure of the density of a distribution of particles traveling with a guiding center along randomized field lines near the core and discuss their impact on the ionization …

Imperial Ideology And Subversive Practice In Arthurian Legend, Emma Katherine Keppler

Open Access Theses & Dissertations

This project approaches Arthur and Arthurian legend as vital elements in British self-identification from the medieval period onward by examining narratives of national origin in legendary history, romance, and other forms of cultural production. In my readings of these texts, I am concerned with how national identity and otherness are constructed and negotiated in a literary space, how myths of utopian origins rely on the endorsement and glorification of cultures of violence that sustain and justify imperial enterprises in the Middle Ages and beyond. It is my argument that in the absence of actual voices of resistance, romance tropes often …

Finding Strength In The Struggle: The Impact Of Resilience On Life Satisfaction Among Veterans With Mental Illness, Marissa Gonzalez

Open Access Theses & Dissertations

Background: Veterans living with mental illness often face challenges that impact their overall life satisfaction and adjustment to civilian life. While resilience is widely considered a protective factor, limited research has examined its role in conjunction with personality traits, psychosocial factors, and demographic characteristics. Purpose: This cross-sectional study examined the associations between resilience and life satisfaction among U.S. veterans with mental illnesses, while accounting for personality dimensions, demographic variables, and psychosocial factors. Methods: Secondary data from 156 veterans diagnosed with mental illness were analyzed. Hierarchical linear regression was used to assess the relationship between resilience and life satisfaction, controlling for …

A Numerical Study Of Self-Assembling Amphiphilic Systems, Joshua Albert Sackey

Open Access Theses & Dissertations

Mixing processes in ternary mixtures involve immiscible fluids such as oil and water, and a surface-active molecule called surfactant. These physical processes find applications in various fields, including enhanced oil recovery, drug delivery design systems, and the formulation of cleaning products. Even though this process has several applications, the mathematical models describing it and the numerical methods solving it are not well understood. The underlying mathematical model is a nonlinear initial-boundary value problem involving sixth-order derivatives and belongs to the class of sixth-order Cahn-Hilliard equations. Authors Sharma and Tierra recently proposed a numerical method to approximate its solutions in two …

Regulation Of Ccr7 Signaling Events By G-Protein-Coupled Receptor Kinases 2 And 3, Anahi Sanchez

Open Access Theses & Dissertations

G protein-coupled receptors (GPCR) can bind multiple ligands, leading to differential signaling events termed biased signaling. C-C chemokine receptor 7 (CCR7) is a GPCR known to have biased signaling between the two ligands it binds to, CCL19 and CCL21. Binding of C-C Chemokine Ligand 19 (CCL19) promotes a high level of CCR7 phosphorylation, while CCL21 leads to a much lower level of CCR7 phosphorylation; findings observed in HEK and dendritic cells. GPCR kinases (GRKs), which can control the phosphorylation patterns of a GPCR, are hypothesized to regulate biased signaling of a receptor. GRK expression differs between cell lines and cell …

De Novo Design Of Ablative Polymers For Aerospace Thermal Protection Systems Through An Integrated Ai-Theory-Experiment Approach, Rene Damaso Boisseau

Open Access Theses & Dissertations

Novolac phenolic resin (NPR) is a widely used polymeric ablative material (PAM) for thermal protection systems (TPS) due to its high thermal decomposition temperature (TD, 500â?¯Â°C) and char yield (YC, 55â?¯wt%). However, its drawbacks (including high thermal conductivity, low mechanical properties and water uptake) prompt the need for improved PAMs. This study explores the pyrolysis behavior and char-forming capabilities of NPR and a potential alternative PAM, poly(1,6-dimethyl phenol) (PPO), through both theoretical and experimental approaches. A graph neural network (GNN) was developed to predict structure-property relationships, revealing that benzyl group positioning and oxygen atom placement significantly influence YC. PPO's para-positioned …

Per- And Polyfluoroalkyl Substances In A Suburbanizing Watershed, Bailey Mullins

Master's Theses and Capstones

Per- and polyfluoroalkyl substances (PFAS) are persistent man-made chemicals that accumulate in aquatic environments due to their widespread industrial and commercial use and resistance to degradation. Understanding their spatial distribution and relative abundance in streams draining suburbanizing watersheds is crucial for effective watershed and water quality management. This study investigates how the concentrations and composition of PFAS in surface water and sediment are impacted by urbanization. PFAS were quantified in the Lamprey River watershed, a coastal watershed in southeastern New Hampshire that is experiencing ongoing suburbanization. Sampling sites include tributaries, mainstem, and estuarine areas. Surface water, sediment, and well water …

Identifying Microbial Complexities And Control Strategies At Pre-Harvest Poultry Production, Tolulope Tiwa Ogundipe

Graduate Theses and Dissertations

While significant progress has been made in post-harvest control of Salmonella in the poultry industry, the development of effective pre-harvest intervention strategies remains critical for reducing foodborne pathogens. Environmental reservoirs such as poultry litter and drinking water systems (DWS) are potential harborage sites for Salmonella and other microbial communities. Understanding the microbiota of these environments, including biofilms within water lines, is essential to identifying factors contributing to Salmonella colonization and improving pre-harvest control approaches. This study aimed to evaluate the incidence and quantity of Salmonella in poultry litter and water lines, characterize the microbial populations in these environments, and assess …

Crispr-Cas9 Integration Of Salmon Elovl2 In Zebrafish Enhances Lc-Pufa Biosynthesis And Growth Across Diets, Waleed Sami J. Al-Bachry

Graduate Theses and Dissertations

Fish are a rich source of EPA and DHA, which are well-known long-chain polyunsaturated fatty acids (LC-PUFAs). The sustainable production of these essential fatty acids poses significant challenges, mainly due to our dependence on marine fish and certain nuts. CRISPR-Cas system was utilized to insert the elongation of long-chain fatty acids-like2 (Elovl2) gene from Salmo salar into Danio rerio. Elovl2 was introduced at 10-15-minute post-fertilization, and successful integration confirmed by PCR genotyping, sequencing and expression of EGFP. Approximately 67% of injected embryos successfully exhibited EGFP and sequence results verified the gene integration of Salmo salar Elovl2 at the first start …

A New Method Using Lidar And Well Logs To Identify And Correlate The Pennsylvanian Atoka Formation Subdivisions In The Surface Outcrops Of The Boston Mountains, Arkansas, Robert Brent Boyd

Graduate Theses and Dissertations

The surface outcrops of the Boston Mountains in northwest Arkansas primarily consist of the Pennsylvanian Atoka formation. Where fully preserved in the Arkoma Basin to the south, the Atoka formation exceeds 18,000 ft of sand and shale. However, it remains undifferentiated on the surface geological map of Arkansas. This study investigates the possibility of identifying and correlating the subsurface subdivisions of the Atoka Formation to the surface outcrops of the Boston Mountains using a new method. Recognizing the Atoka subdivisions in surface outcrops using standard lithology and biostratigraphy correlation techniques has been challenging. The subdivision of the Atoka has instead …

Gender Craze: Framing Policy Discrimination Against Transgender Students In K-12 Education, Quinette Rogers

Graduate Theses and Dissertations

Transgender youth in K-12 public education have been systematically marginalized through state-sanctioned violence and discriminatory policies, often portrayed as societal "boogeymen." They face exclusion and othering due to restrictive state legislation, such as bathroom bans, sports participation restrictions, and limited access to gender-affirming care. Current research lacks a comprehensive analysis of how state-level legislation affects transgender students. This study addresses that gap by employing qualitative thematic coding to examine the language, framing, and impact of state education policies on transgender students. By analyzing how these policies are framed around themes such as protecting family, safeguarding children, individual liberty, constitutional rights, …

Section 276 Applications In Intimate Partner Sexual Assault Cases: The Impact Of R V Goldfinch, Janine Benedet, Isabel Grant

UBC Law Review

No abstract provided.

Placing Expediency Before Principle: An Empirical Analysis Of The Joint Sentencing Practices Of Canadian Crown Prosecutors And Defence Lawyers, Sharmi Jaggi

UBC Law Review

No abstract provided.