Digital Commons Network^™

Investigating Prefrontal Cortex Neuronal Signatures Of Opioid-Induced Risk-Taking Behavior, Cana Quave

Dissertations and Theses (Open Access)

Opioid use disorder occurs alongside impaired risk-related decision-making, but the underlying neural correlates are unclear. We developed an approach-avoidance conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the saline-exposed control group avoided cat odor, the morphine group included two subsets of rats that either maintained a preference for the paired side despite the presence of …

Stat3, Nf-Κb, And Estrogen Receptor Beta: The Balance Of Inflammation In K-Ras Mutant Lung Adenocarcinoma, Michael J. Clowers

Dissertations and Theses (Open Access)

K-ras mutant lung adenocarcinoma (KM-LUAD) is a difficult-to-treat cancer subtype in which chronic inflammation pervades the tumor immune microenvironment (TIME). Pro-inflammatory pathways dampen the response to treatments, including immune checkpoint inhibitors, necessitating therapies that target this inflammatory signaling network in the TIME. This network is underpinned by interaction and coordination of two inflammatory pathways: signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappa B (NF-κB). The balance of these transcription factors determines the degree of anti- vs. pro-tumor immunity, and a skewing towards STAT3 is known to promote tumor development and a pro-tumor TIME. It is also …

Mhc Class I Tyrosine Phosphorylation Site Y320 Augments Cd8+ T Cell Priming, Effector Function, And Memory Response, Yimo Sun, Gregory A Lizee, Yitao Tang, Priscilla Ortiz, R Eric Davis

Dissertations and Theses (Open Access)

The cytoplasmic domain of MHC class I (MHC-I) molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a Y320F-mutated form of H-2K^b had reduced capacity to generate K^b-restricted cytotoxic T lymphocyte (CTL) responses following viral infection, due (at least in part) to defects in endolysosomal trafficking of H-2K^b and antigen cross-presentation by dendritic cells (DCs). In this study, we investigated whether there are additional, post-presentation dependencies on Y320 for T-cell priming. We engineered both human- and mouse-derived antigen-presenting cells (APCs) to express either wild-type MHC-I or variants of …

Automated To Ols For Contour Review In Radiotherapy, Barbara Marquez

Dissertations and Theses (Open Access)

Peer review of organ-at-risk and target volume delineation is essential for patient safety and optimization of treatment outcomes. Peer review makes a substantial impact on patient outcomes, reporting notable rates of plan changes when reviewed and worse survival when patient cases are not reviewed. In around half of revised cases, target volume change is the required cause for modification (related to tumor control); in one in ten cases, it is normal tissue sparing (related to treatment toxicity). Essentially all North American institutions with accredited residency training programs hold peer review to some capacity. However, accessibility to practicing routine peer review …

The Sheriff's Constitution, Farhang Heydari

Vanderbilt Law School Faculty Publications

The county sheriff is unique among our nation's law enforcers, with an ancient pedigree, elected status, and special protections as a state constitu- tional officer. But these factors combine to cause a recurrent problem elected sheriffs often assert for themselves the power to refuse to enforce criminal laws of their choosing. Today's constitutional sheriffs-a group of sheriffs who view themselves as the highest authority in their county, answerable only to their electorate-are the latest manifestation of this ethos, declaring opposition to gun control measures, pandemic restric- tions, environmental protections, and more. Lest one think these nonen- forcement decisions are entirely …

Innovation And Genre In Nonnus’S Dionysiaca, Arianna Loewen

Classical Studies Honors Theses

No abstract provided.

Ai V. Mqd: Navigating New Regulatory Challenges In The Life Sciences, Hayden W. Smith

William & Mary Law Review

This Note proceeds in four parts. Part I introduces AI as an emerging technology in the life sciences, the FDA’s inherited regulatory regime, and challenges under the MQD [major questions doctrine]. Part II explores how hypervigilant regulation obstructs innovation and exposes agencies to judicial challenges. Part III offers solutions to safely and effectively navigate the major questions landscape within a framework that fosters AI innovation. This Note proposes a solution that conceptually balances growth in the life sciences with the statutory elements required for a safe and effective regulatory scheme.

This abstract has been taken from the author's introduction.

The State Of Latino-Serving Community-Based Organizations In Massachusetts, Fabián Torres-Ardila, Phillip Granberry, Rachel Paz, Luna Páez Abaunsa, Valentina Valderrama Pérez

Gastón Institute Publications

Massachusetts has a diverse Latino population with large numbers of Puerto Ricans, Dominicans, Salvadorans, Guatemalans, and Mexicans. Nearly a third (32%) of the Latino population is foreign-born. Of this foreign-born population, 61% are not U.S. citizens. Nearly 210,000 Latino children are enrolled in K-12 schools. Of the Latino population over age five who speak Spanish in the home, 33% have limited English proficiency. Among the adult population, 28% have less than a high school education, and 60% are in the labor force.3 The varied needs of this population require a strong ecosystem of local organizations that provide services to support …

Assessing The Utilization Of Building Information Modelling (Bim) In The Preservation Of Cultural Heritage: A Case Study Of Ashe-Street Courthouse, Boluwatife J. Oluwamakinde

Electronic Theses and Dissertations

This study examines how Building Information Modeling (BIM) was used in the Ashe Street Courthouse restoration, with an emphasis on its role in heritage preservation. It follows a context-oriented instrumental case study methodology and a systematic four-step approach: reviewing literature and historical records, conducting semi-structured interviews with renovation architects, and analyzing project documentation. The study compares BIM with traditional methods to assess documentation quality, stakeholder collaboration, and project efficiency. Findings show that BIM increases documentation accuracy through real-time modifications while preserving historical data. It also enhances collaboration by providing a centralized platform for architects, engineers, and preservation specialists, reducing errors …

Climate Change And The Field Of Farm Labor In The Lower Rio Grande Valley, Texas, Cody Richard Mortell

Theses and Dissertations

Farm workers in the United States are often vulnerable to adverse impacts of climate change, particularly extreme heat. This study explores farm workers’ climate change perceptions (CCP) as a mediating force in climate adaptation. Using latent class analysis, in-person survey data (n=404) from Lower Rio Grande Valley, TX (2024) and NOAA data were analyzed. Results were interpreted using Bourdieu’s field analysis framework and his notions of capital and symbolic power. Findings include: a social hierarchy with three latent classes of workers based on economic, cultural, social, and symbolic capital, which statistically significantly affected CCP. Workers in higher structural positions were …

Exploring The Influence Of Social Media Communication On Destination Branding: A Study Of Saudi Arabia, Abdullah Alshehri

Graduate Theses and Dissertations (2019 - present)

Tourists now find social media important in forming their perceptions and decision criteria when traveling. This Research investigates the impact of destination marketing organizations -generated content and tourist-generated content on tourists' inspiration to visit Saudi Arabia, emphasizing the mediating role of destination image dimensions (cognitive, affective, and sensory) and the moderating role of cultural distance. Based on the Elaboration Likelihood Model, Hofstede Cultural Dimension Theory; the research analyzed a dataset of 237 responses using Partial Least Squares Structural Equation Modelling (PLS-SEM). The findings reveal that destination marketing organizations -generated content and tourist-generated content significantly enhance perceived advertising value, which in …

“África Es Nuestro Corazón, Nuestra Sangre”: Cuban Revolutionary Internationalism In Africa During The Inter-Conference Period, 1966-1979, Nathan C. Sommer

Undergraduate Honors Theses

Cuban foreign policy demonstrated continuity in Africa between the Tricontinental Conference of 1966 and the Sixth Summit of the Non-Aligned Movement in 1979. I look at Cuban involvement in African liberation movements of the mid-1960s to characterize the initial launch of Cuba’s yet-to-be fully developed Africa policy. Next, through the lens of the Ogaden War, I examine at the evolution of Cuban foreign policy in the late 1970s. By the time representatives from 82 countries came to Havana in January 1966, Cuba was heralded by the majority of non-aligned countries for their bravery and selflessness. By the late 1970s, significant …

The Onondaga Nation's Land Claim: Rights Without A Remedy?, Larissa Speak

American Indian Law Journal

No abstract provided.

Case Law On American Indians: September 2023 - August 2024, Thomas P. Schlosser

American Indian Law Journal

No abstract provided.

Susan Ayres, Susan Ayres

Faculty CVs

No abstract provided.

Using Gaussian Process Regression To Learn Thermodynamic Equations Of State With Uncertainty Quantification, Austen T. Lee

Chemical Engineering Undergraduate Honors Theses

This study investigates the use of derivative-informed Gaussian Process (GP) models to estimate thermodynamic behavior across temperature and density by building a Helmholtz-based equation of state. Argon, a stable monatomic gas, was chosen as a case study within the vapor region. The GP model was trained using values of experimentally measurable properties found by taking first and second derivatives of the original potential function. Results show that while the GP model offered uncertainty quantification and informed thermodynamic behavior, it predicted values that deviated from the ground truth depending on the property. The model exhibited high confidence in regions with substantial …

Organizational Care: The Formation And Reproduction Of Social Support Structures In Nonprofit Organizations, Ella Stanley

Communication Undergraduate Honors Theses

Through past literature it has been established that nonprofit employees are prone to experience increased levels of stress and burnout due to the emotionally taxing nature of their jobs. Social support is a communicative transaction between individuals that has been proven to mitigate the negative impacts that both stress and burnout can cause employees to face. Previous studies on social support have focused on healthcare workers and nonprofit volunteers, while this study aims to understand the specific social support structures that are prominent within nonprofit organizations to provide support for employees. This study utilizes structuration theory to explore the structures …

Learning Educational Technology Prototyping With Generative Ai, Justin Olmanson, Azadeh Hassani, Gretchen K. Larsen

Department of Teaching, Learning, and Teacher Education: Faculty Publications

In this study, we use ethnographic methods, grounded theory, and an iterative analytical approach to explore participant experiences and strategies for engaging generative AI in support of both learning how to prototype educational technologies and learning to code. We examine how ChatGPT and Giuseppe (a scaffolded co-coding interface of our own design) influence students’ approaches to prototyping and programming. This study contributes to the field by: identifying specific challenges and affordances of generative AI in prototyping and educational technology development contexts; and offering insights into how educators, students, and learning technology developers can integrate generative AI in formative educational technology …

Elevated P16ink4a Expression Enhances Tau Phosphorylation In Neurons Differentiated From Human-Induced Pluripotent Stem Cells, Kristopher Holloway, Kashfia Neherin, Yingduo Song, Kazuhito Sato, Andrew Houston, Feng Chen, Li Ding, Hong Zhang

2020-Current year OA Pubs

Increased expression of the cyclin-dependent kinase inhibitor p16Ink4a (p16) is detected in neurons of human Alzheimer's disease (AD) brains and during normal aging. Importantly, selective eliminating p16-expressing cells in AD mouse models attenuates tau pathologies and improves cognition. But whether and how p16 contributes to AD pathogenesis remains unclear. To address this question, we tested whether induction of p16 expression in neurons exacerbates AD pathologies. We created a doxycycline-inducible system to trigger p16 up-regulation in human-induced pluripotent stem cells (iPSCs) and neurons differentiated from iPSCs. We demonstrated that up-regulated p16 expression in iPSCs reduces cell proliferation, down-regulates cell cycle genes, …

Recommendations For Design, Execution, And Reporting Of Studies On Experimental Thoracic Aortopathy In Preclinical Models, Ketan B Ghaghada, Jay D Humphrey, Scott A Lemaire, Yanming Li, Ziad Mallat, Yvan Saeys, Hisashi Sawada, Ying H Shen, Toru Suzuki, Zhen Zhou

Faculty, Staff and Students Publications

There is a recent dramatic increase in research on thoracic aortic diseases that includes aneurysms, dissections, and rupture. Experimental studies predominantly use mice in which aortopathy is induced by chemical interventions, genetic manipulations, or both. Many parameters should be deliberated in experimental design in concert with multiple considerations when providing dimensional data and characterization of aortic tissues. The purpose of this review is to provide recommendations on guidance in (1) the selection of a mouse model and experimental conditions for the study, (2) parameters for standardizing detection and measurements of aortic diseases, (3) meaningful interpretation of characteristics of diseased aortic …

Achieving Fairness In Zoning Laws With Machine Learning, William Schimitsch

College Honors Program

Zoning is a powerful regulatory tool that determines how municipalities use and develop land. The goal of zoning is to classify land use (e.g., residential, commercial, industrial) to maximize compatibility among neighboring parcels. Local zoning decisions, however, are made by small-sized boards, often through an opaque process, which raises concerns about bias and fairness. In the United States, zoning has historically prioritized single-family housing and thus created economic barriers that limit access to certain communities. Given the task of classifying land use and the wealth of geographical, demographic, and infrastructural data describing each parcel, the problem of bias in zoning …

Navigating Travel Therapy: Balancing Benefits And Risks For Optimal Wellness, Fangli Hu, Jun Wen, Wei Wang

Research outputs 2022 to 2026

This research note examines travel therapy as a novel healthcare approach in which positive travel experiences serve to promote well-being. It emphasizes the need for a balanced assessment of the benefits and risks associated with travel therapy, offering insights into this practice's evolving roles in the health and wellness domains.

Do Parents ‘Know Best’ When It Comes To Their Teenaged Children’S Experiences Of Sexual Content Online?, Harrison W. See, Kjartan Ólafsson, Brian O’Neill, Lelia Green, Carmen Jacques, Kelly Jaunzems

Research outputs 2022 to 2026

In 2010, the EU Kids Online project, and aligned AU Kids Online study, interviewed one parent and one child (9–16) from 25,542 families across 26 countries. Information gathered included parents’ awareness of their child’s experiences of sexual content online. This dataset has since been updated by recent ethnographic work in Australia and Ireland, capturing parents’ approaches to managing their children’s (11–17) digital engagement with sexual content. Parents identified risks and benefits in their children’s encounters with adult content online. This article concludes that parents do not judge the efficacy of their digital parenting around preventing their child from seeing restricted …

Effect Of Relative Age On Gross Motor Coordination Development, Considering Biological Maturity And Sex, Xiaoyu Zhang, Gaël Ennequin, Anthony J. Blazevich, Sébastien Ratel

Research outputs 2022 to 2026

Objective: This study aimed to investigate the effect of relative age on gross motor coordination (GMC) development, taking into account biological maturity and sex. Methods: 729 participants aged 10 to 16 years completed three GMC tests newly designed to minimize the potentially confounding effects of physical fitness. The tests included a Hand-Foot coordination test, Dribbling-Targeting test (DT test), and a T balance and agility test (T test). Relative age was determined using birth quartiles: BQ1 (January–March); BQ2 (April–June); BQ3 (July–September); and BQ4 (October–December). Regarding biological maturity, the participants were categorized according to their estimated peak height velocity (pre- and post-PHV). …

Strength And Conditioning Society (Scs) 7th Annual Meeting, Murcia, Spain, 2024, Pedro E. Alcaraz, Konstantinos Spyrou, Anthony J. Blazevich, Tomás T. Freitas, Elena Marín-Cascales, Aarón Manzanares Serrano

Research outputs 2022 to 2026

On behalf of the Strength and Conditioning Society (SCS), we are pleased to present the abstracts submitted for the SCS 7th Annual Meeting. The event was held at the Universidad Católica de Murcia (UCAM) headquarters in Murcia, Spain, on 9–11 October 2024, and comprised several invited sessions by international and national speakers on a variety of topics related to biochemistry and exercise physiology, strength and conditioning practices and their application to health, injury prevention, and sports performance. These included strength training in high-performance sports, sport science and training–competition load management in elite environments, biochemistry and exercise physiology and prescription, nutrition …

Using Natural Language Processing And Machine Learning To Detect Online Radicalisation In The Maldivian Language, Dhivehi, Hussain Ibrahim, Ahmed Ibrahim, Michael N. Johnstone

Research outputs 2022 to 2026

Early detection of online radical content is important for intelligence services to combat radicalisation and terrorism. The motivation for this research was the lack of language tools in the detection of radicalisation in the Maldivian language, Dhivehi. This research applied Machine Learning and Natural Language Processing (NLP) to detect online radicalisation content in Dhivehi, with the incorporation of domain-specific knowledge. The research used Machine Learning to evaluate the most effective technique for detection of radicalisation text in Dhivehi and used interviews with Subject Matter Experts and self-deradicalised individuals to validate the results, add contextual information and improve recognition accuracy. The …

Young People’S Perceptions Of Harm From Accessing Online Sexual Content, Despina Chronaki, Debra Dudek, Giselle Woodley

Research outputs 2022 to 2026

Harm—and the ways in which it is interpreted, negotiated, discussed, and unpacked by adolescents themselves—is a key term in almost all debates about young people’s experiences with online pornography. This essay situates the topic of this special issue—adolescents’ perceptions of harm from accessing online sexual content—within a broader context of the discourses and practices that inform research in this field. We show how discourses of harm and risk circulate around the figure of the innocent child in need of protection and argue for more nuanced understandings of and research about childhood that take into account the lived experiences and perspectives …

Empirical Evidence Of Factors To Improve Student Engagement From Experiential Learning Activities, Lara Molendijk, Ross H. Taplin, Andrew J. Brennan

Research outputs 2022 to 2026

Experiential learning activities (ELAs) are student-centered activities, such as case studies, that have benefits derived by students being active. Although the literature contains advice on which characteristics enhance ELAs, empirical evidence measuring the impact of these characteristics on engagement is scarce. This paper aims to fill this gap by comparing student engagement from 34 ELAs with varying levels of six characteristics the literature claims are beneficial. Data from a student questionnaire are analyzed with regression and content analyses. The results suggest engagement is most effectively improved when ELAs are authentic and contain the right level of detail and, to a …

What Do Safety And Risk Mean To Women Who Choose To Birth At Home? A Systematic Review, Candice Chauncy, Kate Dawson, Sara Bayes

Research outputs 2022 to 2026

Introduction: Despite clear evidence to support the safety and efficacy of homebirth, the concept challenges the almost universal belief that hospital is the safest place to give birth. Homebirth remains largely unsupported around the world due to prevailing beliefs and constructs surrounding risk and safety. Despite barriers to access, women continue to choose home as a place to birth. Methods: A systematic review of qualitative research was conducted to explore and understand women's views on what constitutes risk and safety in labour and birth for those who choose to birth at home. All studies were evaluated for quality and relevance. …

Misconceptions Among Mental Health Treatment Providers About Ocd And Ptsd, Carmen P Mclean, Terri L Fletcher, Natalie E Hundt, Lauren P Wadsworth, Nathaniel Van Kirk, Stephanie Y Wells, Jonathan S Abramowitz, Wayne K Goodman, Eric A Storch

Faculty, Staff and Students Publications

Obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD) share overlapping features for which similar cognitive behavioral treatment (CBT) strategies can be employed. However, the comorbid presence of these conditions poses unique clinical considerations, and a nuanced approach to assessment, conceptualization, and treatment is needed when working with individuals with co-occurring OCD and PTSD. Treatment providers may not be aware of these nuances and may hold misconceptions about co-occurring OCD and PTSD, impacting their approach to assessment, conceptualization, and treatment. The current study sought to examine possible misconceptions among mental health treatment providers of differing specializations. Among 146 primarily CBT-oriented treatment …