Digital Commons Network^™

Online Data Breaches, Standing, And The Third-Party Doctrine, Adam Lamparello

Cardozo Law Review de•novo

This Essay argues that, in the context of online data breaches, these doctrines hinder consumers from receiving full monetary compensation and do not adequately safeguard privacy rights. For example, courts frequently dismiss consumers’ suits against online service providers for lack of standing, which results in consumers bearing the cost for damages that the providers were in a position to prevent. This Essay argues that the Supreme Court should relax the standing doctrine’s “imminent harm” requirement and permit consumers to sue providers for mitigation damages. In addition, the Court should abandon the longstanding principle that citizens lose all privacy protections in …

Sketchy Lesbians: "Carol" As History And Fantasy, Patricia White

Film & Media Studies Faculty Works

Rather than a forward-looking lesbian representation, Todd Haynes's Carol, an adaptation by Phyllis Nagy of Patricia Highsmith's 1952 novel, The Price of Salt, looks to images and affective investments of the past to explore lesbian representability, the historical discourses and aesthetic codes through which desire between women can be recognized. The collaboration brings together preoccupations from Haynes's oeuvre and themes from Highsmith's that question reception of the film in terms of a happy ending and future progress. Through evocative art direction, camerawork, and star performances, the film invites the viewer to share the perspective of Therese (Rooney Mara), …

Hitchhiking The Labyrinth, Tom Gage

The Journal of the Assembly for Expanded Perspectives on Learning

James Moffett’s best friend recalls Moffett’s enduring influence on his own extraordinary career, as well as Moffett’s substantial contributions to AEPL.

Exceptions Meet Absolutism: Outlawing Governmental Underreach In Health Law, Christina S. Ho

Denver Law Review

No abstract provided.

Branding Identity, Kate Sablosky Elengold

Denver Law Review

No abstract provided.

A Market Analysis Of Race-Conscious University Admissions For Students Of Color, Adriane Kayoko Peralta

Denver Law Review

No abstract provided.

Open Skies, Timothy M. Ravich

FIU Law Review

No abstract provided.

Les Catastrophes Enironnementales Et Leurs Conséquences Sur La Santé Publique" Une Année Passée En Revue, Susan Johnson, Blythe Brauer, Samantha Bird, Andrea Abergel, Jon Davey, Mary Strayhorne

PEEL Alumni Scholarship

Cette annee, plusieurs catastrophes environnementales ont eu des consequences tres graves sur la sante publique. Cet article analyse les causes, les effets et les implications juridiques et politiques de quatre différents désastres industriels recenses cette année. En premier lieu, I'article traite d'une explosion industrielle qui s'est produite dans l'Etat du Texas en avril 2013. Cette explosion est le résultat de I'entassement négligeant de matériaux chimiques dans une zone rurale du Texas. Dans un second temps, est aborde l'effondrement d'une usine de textile située au Bangladesh, symptôme d'une mondialisation sauvage hors de contrôle des gouvernements. Enfin, I'article aborde trois différents événements …

"Made In Ethiopia" -- The New Norm In The Garment Industry, Marie Durane

PEEL Alumni Scholarship

Ethiopia is one of the fastest growing economies in the world, achieving enormous economic growth averaging 10.6% over the past decade and leading in Foreign Direct Investment (FDI). According to the 2014 United Nations Conference on Trade and Development (UNCTAD) World Investment Report, FDI in Ethiopia has increased by 242% from 2012 to 2013. However, the excessive speed at which Ethiopia is seeking foreign investment into the country, specifically in the garment industry, has led to an exploitation of garment workers who are paid extremely low wages. To ensure garment workers are paid fairly, Ethiopia should establish a minimum wage …

Mexican Energy Revolution: But Is It A Solution?, Katrina Tomecek

PEEL Alumni Scholarship

Mexico’s recent energy reform has received much praise for the economic benefits it promises to bring, but one piece of the puzzle most politicians seem to overlook is the environmental impact that will result and the issues with postponing the inevitable: the need to look to alternative resources. With its ample sun and wind resources, Mexico would be an ideal candidate for transitioning to greener energy. However, without strategic planning the country’s energy reform will threaten to undo recent progress towards the transition to renewable resources.

Closing The Halliburton Loophole In New Mexico: Letting Developers Choose Between R&D Dollars And Trade Secrets, Christian Johnson

PEEL Alumni Scholarship

During the last fifteen years, the southwestern United States has recorded exceptional levels of drought and is experiencing a severe water crisis. At the same time, billions of gallons of freshwater are being used each year to supply a booming natural gas development. While not much can be done about the drought, water use could be better monitored and controlled. Deep fracturing technology, or “fracking,” permanently denies human beings the future use of billions of gallons of freshwater because the water used to extract natural gas must be mixed with toxic chemicals, most of which cannot be economically removed.

University Food Gardens: A Unifying Place For Higher Education Sustainability, Leslie A. Duram, Sydney K. Klein

Publications

This research describes the key characteristics of campus food gardens and investigates their contribution to overall campus sustainability. An email-survey of fifty-two campus garden managers in North America provided quantitative and qualitative data for this analysis. It was found that gardens are often student initiated and managed, but also bring together diverse stakeholders from the campus and community. These sites increase sustainability awareness as well as overall institutional sustainability. University food gardens provide formal education that overcomes many institutional barriers to interdisciplinary programs. Informal education also occurs at these sites through experiential learning which leads to greater environmental awareness among …

The 2014 Illinois Governor Race: Quinn Vs Rauner, John S. Jackson

The Simon Review (Occasional Papers of the Paul Simon Public Policy Institute)

The 2014 Governor’s race in Illinois featured two candidates who are the epitome of campaigns for high office in America today. In addition, the race also illustrated the major trends, driven by big money and big media, which are shaping our politics in the 21st century. This paper examines and analyzes the governor’s race in order to learn what it teaches us about politics in Illinois, and in the United States midway through the second decade of this century.

Intrinsically Disordered Proteins And Their (Disordered) Proteomes In Neurodegenerative Disorders, Vladimir N. Uversky

Molecular Medicine Faculty Publications

No abstract provided.

Beyond The Excluded Volume Effects: Mechanistic Complexity Of The Crowded Milieu, Irina M. Kuznetsova, Boris Y. Zaslavsky, Leonid Breydo, Konstantin K. Turoverov, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Macromolecular crowding is known to affect protein folding, binding of small molecules, interaction with nucleic acids, enzymatic activity, protein-protein interactions, and protein aggregation. Although for a long time it was believed that the major mechanism of the action of crowded environments on structure, folding, thermodynamics, and function of a protein can be described in terms of the excluded volume effects, it is getting clear now that other factors originating from the presence of high concentrations of “inert” macromolecules in crowded solution should definitely be taken into account to draw a more complete picture of a protein in a crowded milieu. …

Structure And Stability Of Recombinant Bovine Odorant-Binding Protein: Ii. Unfolding Of The Monomeric Forms, Olga V. Stepanenko, Denis O. Roginskii, Olesya V. Stepanenko, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

Molecular Medicine Faculty Publications

In a family of monomeric odorant-binding proteins (OBPs), bovine OBP (bOBP), that lacks conserved disulfide bond found in other OBPs, occupies unique niche because of its ability to form domain-swapped dimers. In this study, we analyzed conformational stabilities of the recombinant bOBP and its monomeric variants, the bOBP-Gly121+ mutant containing an additional glycine residue after the residue 121 of the bOBP, and the GCC-bOBP mutant obtained from the bOBP-Gly121+ form by introduction of the Trp64Cys/His155Cys double mutation to restore the canonical disulfide bond. We also analyzed the effect of the natural ligand binding on the conformational stabilities of these bOBP …

The Inalienable Right To Stand Your Ground, Joshua Prince, Allen Thompson

St. Thomas Law Review

This Article seeks to open a dialogue about an individual's inalienable Right to Self-Defense and the interplay between that Right and Stand Your Ground doctrines. In Section II, this Article will present an overview of what, precisely, a Stand Your Ground statute actually encompasses and permits, as many misconceptions have arisen as to the effect of a Stand Your Ground law. Due to the position many political groups have taken, as well as inaccurate news reporting by the media, there is a mistaken belief that Stand Your Ground laws allow a shooter to become "judge, jury, and executioner." In Section …

Doin' Time For An Unproven Crime: The Problem Of Unpreserved Evidence Sufficiency Issues In Criminal Appeals, Richard Sanders

St. Thomas Law Review

Sections I and II of the article lay out the general principles of the preservation rule and its fundamental-error exception. Section III discusses the Florida cases that have wrestled with the problem of unpreserved sufficiency issues in criminal cases. The problem in the cases-seen in F.B. and in the pre-F.B. district court cases-is that Florida courts do not say that all valid-but-unpreserved sufficiency issues should be remedied as fundamental error. This means there will be some cases where the evidence in the record fails to establish all the elements of the crime of conviction but the court will affirm because …

Bringing Operation Pedro Pan Back From Never Never Land: Is Ina 207(B) The President's Solution To The Humanitarian Crisis At The Border, Emily C. Callan

St. Thomas Law Review

The choice to bestow refugee designation on the growing unaccompanied minor children population would no doubt carry far-reaching and long-lasting consequences of its own. Because of these potential important and complex ramifications, a closer examination of the implications of the President utilizing his authority under Section 207(b) must be undertaken. To do so, Part I of this article provides a brief description of the origin of refugee law in general and Section 207(b) in particular. Part II explains the previous instances wherein past presidents exercised their authority to help foreign nationals seek refuge in the United States. Part III further …

Better The Mob And The Ku-Klux: A History Of The Law Of Search And Seizure In Florida, Milton Hirsch

St. Thomas Law Review

As late as 1930, and on several occasions prior to that date, Harvard Law Professor Felix Frankfurter could offer, as an example of something that the Supreme Court would almost never be called upon to decide, "whether the [Fourth Amendment] protection against 'unreasonable searches and seizures' is violated. In 1939 Professor Frankfurter was appointed to the High Court, where he would serve for 23 years; and where, as Justice Frankfurter, he would participate in a great many notable opinions having to do with whether the Fourth Amendment protection against unreasonable searches and seizures had been violated. That Professor Frankfurter made …

Where The Sea Meets The Land, Marianne L. Catala

St. Thomas Law Review

Part L.A of this comment discusses the history and evolution of the public trust doctrine, which dates back to Roman and Old English common law. It asserts the public has a pre-existing right to the dry sand portion of the beach, a right that has been wrongfully limited in Florida by its current public trust doctrine. Part I.C examines the uniqueness of beach property, and explains how the traditional notions of private property cannot succeed in overcoming the public's pre-existing right to the beach. The fact remains that over time the public right to use and enjoy the beach in …

Children Of A Lesser Jones: Punitive Damages In Unseaworthiness, Attilio M. Costabel

St. Thomas Law Review

The title of the famous stage play and movie, Children of a Lesser God, comes from a stanza of Alfred Lord Tennyson's, Idylls of the King, which reads as follows, "As if some lesser god had made the world, but had not force to shape it as he would." Like Tennyson's lesser God, Congress enacted the Jones Act, but did not have the force to shape it as it was supposed to be. On the contrary, it allowed the courts to interpret, twist and abuse it to the furthest limits, well beyond even the questionable ones imposed by Miles v. …

Should Therapeutic Jurisprudence Be Used To Analyze Impacts Of Legal Process On Government, Carol L. Zeiner

St. Thomas Law Review

This article takes the controversial position that despite therapeutic jurisprudence's (sometimes referred to as "TJ") focus on the impact of laws and legal processes on the emotional and related physical well-being of human beings, there can be TJ-like impacts on government, at least in certain circumstances, that can be discovered by making a TJ analysis of the situation. It further contends that these TJ-like impacts on government ought to be examined for a number of important reasons: (1) they provide greater insights into therapeutic and antitherapeutic impacts on humans; (2) the deeper understandings gained through this analysis can then be …

Intrinsically Disordered Caldesmon Binds Calmodulin Via The “Buttons On A String” Mechanism, Sergei E. Permyakov, Eugene A. Permyakov, Vladimir N. Uversky

Molecular Medicine Faculty Publications

We show here that chicken gizzard caldesmon (CaD) and its C-terminal domain (residues 636–771, CaD136) are intrinsically disordered proteins. The computational and experimental analyses of the wild type CaD136 and series of its single tryptophan mutants (W674A, W707A, and W737A) and a double tryptophan mutant (W674A/W707A) suggested that although the interaction of CaD136 with calmodulin (CaM) can be driven by the non-specific electrostatic attraction between these oppositely charged molecules, the specificity of CaD136-CaM binding is likely to be determined by the specific packing of important CaD136 tryptophan residues at the CaD136-CaM interface. It is suggested that this interaction can be …

Fendiline Inhibits Proliferation And Invasion Of Pancreatic Cancer Cells By Interfering With Adam10 Activation And Β-Catenin Signaling, Neha Woods, Jose Trevino, Domenico Coppola, Srikumar Chellappan, Shengyu Yang, Jaya Padmanabhan

Molecular Medicine Faculty Publications

ADAM10 (A Disintegrin and Metalloprotease Domain 10) affects the pathophysiology of various cancers, and we had shown that inhibition of ADAM10 sensitizes pancreatic cancer cells to gemcitabine. ADAM10 is activated in response to calcium influx, and here we examined if calcium channel blockers (CCB) would impede ADAM10 activation and affect biology of pancreatic cancer cells. We find that the CCB, fendiline, significantly reduces proliferation, migration, invasion, and anchorage independent growth of pancreatic cancer cells. This was associated with ADAM10 inhibition and its localization at the actin-rich membrane protrusions. Further, fendiline-treated cells formed cadherin-catenin positive tight adherens junctions and elicited defective …

Structure And Stability Of Recombinant Bovine Odorant-Binding Protein: I. Design And Analysis Of Monomeric Mutants, Olga V. Stepanenko, Denis O. Roginskii, Olesya V. Stepanenko, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

Molecular Medicine Faculty Publications

Bovine odorant-binding protein (bOBP) differs from other lipocalins by lacking the conserved disulfide bond and being able to form the domain-swapped dimers. To identify structural features responsible for the formation of the bOBP unique dimeric structure and to understand the role of the domain swapping on maintaining the native structure of the protein, structural properties of the recombinant wild type bOBP and its mutant that cannot dimerize via the domain swapping were analyzed. We also looked at the effect of the disulfide bond by designing a monomeric bOBPs with restored disulfide bond which is conserved in other lipocalins. Finally, to …

Intrinsic Disorder In Biomarkers Of Insulin Resistance, Hypoadiponectinemia, And Endothelial Dysfunction Among The Type 2 Diabetic Patients, Osama H. Jiffri, Fadwa M. Al-Sharif, Essam H. Jiffri, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is strongly associated with the all-cause and cardiovascular mortality. The present study aimed to analyze the abundance and functionality of intrinsically disordered regions in several biomarkers of insulin resistance, adiponectin, and endothelial dysfunction found in the T2DM patients. In fact, in comparison to controls, obese T2DM patients are known to have significantly higher levels of inter-cellular adhesion molecule (iCAM-1), vascular cell adhesion molecule (vCAM-1), and E-selectin, whereas their adiponectin levels are relatively low. Bioinformatics analysis revealed that these selected biomarkers (iCAM-1, vCAM-1, E-selectin, and adiponectin) are characterized by …

Intrinsic Disorder In Biomarkers Of Insulin Resistance, Hypoadiponectinemia, And Endothelial Dysfunction Among The Type 2 Diabetic Patients, Osama H. Jiffri, Fadwa M. Al-Sharif, Essam H. Jiffri, Vladimir N. Uversky

Molecular Medicine Faculty Publications

Type 2 diabetes mellitus (T2DM) is a chronic and progressive disease that is strongly associated with the all-cause and cardiovascular mortality. The present study aimed to analyze the abundance and functionality of intrinsically disordered regions in several biomarkers of insulin resistance, adiponectin, and endothelial dysfunction found in the T2DM patients. In fact, in comparison to controls, obese T2DM patients are known to have significantly higher levels of inter-cellular adhesion molecule (iCAM-1), vascular cell adhesion molecule (vCAM-1), and E-selectin, whereas their adiponectin levels are relatively low. Bioinformatics analysis revealed that these selected biomarkers (iCAM-1, vCAM-1, E-selectin, and adiponectin) are characterized by …

Global Data Meets 3-D Printing: The Quest For A Balanced And Globally Collaborative Solution To Prevent Patent Infringement In The Foreseeable 3-D Printing Revolution, Tyler Macik

Indiana Journal of Global Legal Studies

This Note explores a potential global solution to the foreseeable patent infringement problems with 3-D printing and do-it-yourself users. More specifically, at a time when 3-D printing is quickly gaining popularity and recognition for its many beneficial applications through advancements in printing and scanning technology, the current state of patent law lacks the ability to detect and prevent patent infringement among do-it-yourself users of 3-D printing. I propose a potential global solution that would provide a balance between fostering growth in 3-D printing and upholding patentees' rights by exploring the possibility of creating a collaborative, intergovernmental 3-D CAD file database …

Loss Of Multidrug Resistance-Associated Protein 1 (Mrp1/Abcc1) Potentiates Doxorubicin-Induced Cardiotoxicity In Mice, Wei Zhang

Theses and Dissertations--Toxicology and Cancer Biology

Doxorubicin (DOX) is a broad-spectrum and effective chemotherapeutic agent, but its use in oncologic practice is limited by dose-dependent cumulative cardiotoxicity. DOX-induced cardiotoxicity is in large part due to its ability to cause oxidative stress. Multidrug resistance associated protein 1 (MRP1/ABCC1) is a member of the ATP-binding cassette (ABC) transporter superfamily. By effluxing a wide variety of endogenous and exogenous substrates, Mrp1 plays important physiological roles in multiple tissues and also protects normal tissues against toxicants. However, the role of MRP1 in heart is largely unknown.

The role of Mrp1 in DOX-induced cardiotoxicity was investigated in Mrp1 null (Mrp1-/-) and …