Digital Commons Network^™

Functional Selectivity Downstream Of Gαi/O-Coupled Receptors, Tarsis Brust Fernandes

Open Access Dissertations

G protein-coupled receptors (GPCRs) are drug targets that often activate multiple signaling pathways. The multiple GPCR responses provide opportunities for biased or functionally selective ligands to preferentially modulate one signaling pathway over another. Studies with several GPCRs have suggested that selective activation of signaling pathways downstream of a GPCR may lead to safer and more effective drug therapies. The dopamine D2 receptor is the main target in therapies for Parkinson’s disease and schizophrenia. First and second generation antipsychotic drugs antagonize dopamine D2 receptor. Notably, both these classes of drugs may cause side effects associated with D2 receptor antagonism (e.g. hyperprolactemia …

Race. Nation. Zombie: Imperial Masculinities Gazing At The Undead, Adryan Glasgow

Open Access Dissertations

This dissertation argues that zombie narratives have always been about white masculinity and that colonialism is the true living dead monster. The zombie is not the load-bearing signifier in these stories. It is the white men who act as representatives of empire that embody tropes and evolve. This dissertation examines the survivor masculinity in zombie films over time to see how hegemonic masculinity has adapted to a range of national crises. I argue that the failure of white masculinities in these films and novel is rooted in the limited ways of knowing inherent in the Imperial Gaze. Starting in the …

Elementary School Teachers' Attitudes Towards Multilingualism And Language Policy: Kazan, Russia, Alsu M. Gilmetdinova

Open Access Dissertations

The dissertation adopts a transdisciplinary approach to study schools as sites of language policy implementation. Contributions of language policy, TESOL and multilingual education, and linguistic anthropology help understand the role of teachers in language education. Of particular interests are teachers’ attitudes towards multilingualism and language policies, namely, the learning and teaching of national (Russian), titular (Tatar) and foreign (English) languages, as well as teachers’ negotiation of language policies in school. Federal, regional and school policy documents, 25 teacher interviews and site observations from a Tatar-medium school (1), a Russian-medium school (2) and a school with intensive English language program (3) …

"Transistor-Like" Spin Nano-Switches: Physics And Applications, Vinh Quang Diep

Open Access Dissertations

Progress in the last two decades has effectively integrated spintronics and nanomagnetics into a single field, creating a new class of spin-based devices that are now being widely used in magnetic memory devices. However, it is not clear if these advances could also be used to build logic devices.

Inferred Rheology And Upper Mantle Conditions Of Western Nevada And Southern California-Northwest Mexico, Haylee Dickinson

Open Access Dissertations

Understanding the viscous strength (rheology) of the mantle is essential for understanding the dynamics and evolution of the Earth. Rheology affects many geologic processes such as mantle convection, the earthquake cycle, and plate tectonics. This study uses tectonic (postseismic) and non-tectonic (lake unloading) events that have induced differential stress changes within the crust and mantle, which in turn, create surface deformation. The viscoelastic relaxation is constrained using geodetic methods, such as GPS, InSAR, or measurements of shoreline rebound. We can use these observed surface displacements to constrain numerical models of the relaxation processes that can be used to infer a …

Cinderella And Other Fairy Tales As Secular Scripture In Contemporary America And Russia, Kate Christine Moore Koppy

Open Access Dissertations

Koppy, Kate C. M. PhD, Purdue University, December 2015. Cinderella and Other Fairy Tales as Secular Scripture in Contemporary America and Russia. Major Professor: Charles Ross.

Cultural Considerations In Forensic Science In The United States, Suzanna K. Taylor, Wayne P. Bergeron

Politics, Justice, Law, and Philosophy

Does the cultural context of any criminal justice element, ranging from the crime victim to the forensic science expert, have any impact on the pursuit of justice? Is forensic science completely free of cultural adulteration? Two dimensions of the cultural consideration variable this paper focuses on are (1), what areas of forensic analysis need to be considered to prevent, or at least, diminish cultural offenses in processing crime scenes and forensic evidence, and (2) the need of forensic science professionals and organizations to adopt a consistent scientific culture in processing and analyzing evidence (particularly in DNA analysis). While many empirical …

First Graders As Sensitive Social Partners And Skilled Readers, Zaira R. Arvelo Alicea

Open Access Dissertations

This mixed methods dissertation is guided by a sociocultural framework and a pragmatist stance to contribute to early literacy scholarship about minority children. In particular, I explore the relationship between low socioeconomic status Puerto Rican children’s reading experience and their social cognition by: (1) assessing them through quantitative and qualitative measures that reveal their capacities in these areas at the end of their first grade year, and (2) documenting their reading experiences at home and at school through ethnographic qualitative methods. The analyses revealed significant positive correlations between the tests of reading and social understanding, a scarcity of conventional reading …

Creation And Validation Of The Critical Thinking About Sustainability Scale, Vivian Gregory Alexander

Open Access Dissertations

Alexander, Vivian G. Ph.D., Purdue University, December 2015. Creation and Validation of the Critical Thinking about Sustainability Scale. Major Professor: Yukiko Maeda.

Drug Delivery To Solid Tumors Via Polymeric Nanoparticles, Sara Ahmed

Open Access Dissertations

A main challenge in chemotherapy is to deliver an anti-cancer drug selectively to tumor and avoid off-target exposure to other body tissues and organs. Nanoparticles (NPs) have been considered a promising approach for tumor drug delivery, with popularity attributable to the famous “Enhanced Permeability and Retention effect”, where small particles enter tumor tissues through leaky vasculature and be retained there. Currently, the phagocytic clearance of NPs is avoided by coating NP surface with Polyethylene glycol (PEG). Although successful in prolonging NPs circulation, PEG prevents proper interaction of NPs with the target cells, known as “PEG dilemma”. Low molecular weight chitosan …

Killing The Patient To Cure The Disease: Medicare's Jurisdictional Bar Does Not Apply To Bankruptcy Courts, Samuel R. Maizel, Michael B. Potere

Emory Bankruptcy Developments Journal

The Social Security Act requires an exhaustion of administrative remedies prior to judicial review through 42 U.S.C. §§ 405(g) & (h). A hospital's appeal from a claim of overpayment by the government can take years, forcing hospital closure due to a lack of continued Medicare payments. Historically, some bankruptcy courts, looking to legislative history, have found that they lack jurisdiction over Medicare claims prior to the exhaustion of administrative remedies. However, in In re Bayou Shores, SNF, LLC and In re Nurses' Registry and Home Health Corp., the bankruptcy court found that under the plain language of § 405(h) it …

The Non-Dischargeability Of Private Student Loans: A Looming Financial Crisis?, Preston Mueller

Emory Bankruptcy Developments Journal

Unlike the vast majority of consumer debts owed to private lenders, educational loans made by private lending institutions are protected as non-dischargeable under Section 523(a)(8) of the Bankruptcy Code. Because most borrowers cannot shirk their obligations to private student lenders, even by filing for bankruptcy, lenders are willing to lend more in this context than with other dischargeable forms of debt; thus artificially inflating the market for higher education loans. This practice is becoming crucial to the health of our overall economy as student loans have become one of the largest forms of consumer debt in the United States, second …

Consumer Bankruptcy Panel: Undue Hardship: An Analysis Of Student Loan Debt Discharge In Bankruptcy, C. Ray Mullins, Dalié Jiménez, Rafael Pardo, Elaine Poon

Emory Bankruptcy Developments Journal

The Consumer Panel focused on student loan debt, featuring judicial, academic, and practical insights and a call to action to help consumers.

I Pronounce You Man And Man. You May Now File Jointly For Bankruptcy: Doma's Unconstitutionality And Its Effect On Joint Bankruptcy Filings For Same-Sex Couples, Michael Tomback

Emory Bankruptcy Developments Journal

Windsor v. United States marked the erosion of the Defense of Marriage Act of 1996. Post-Windsor, the operative definition sections of that Act'defining 'marriage' and 'spouse' for 'any Act of Congress''no longer control. The meaning of marriage and spouse under federal law and, specifically, the Bankruptcy Code is now unclear. This Article argues that lawfully married same-sex couples should be allowed to file for bankruptcy jointly under 11 U.S.C. § 302 in all bankruptcy courts, even if the couple files jointly in a state that does not recognize their union. Under federalism principles, the Bankruptcy Code should apply the definitions …

Amending The Flaws In The Safe Harbors Of The Bankruptcy Code: Guarding Against Systemic Risk In The Financial Markets And Adding Stability To The System, Peter Marchetti

Emory Bankruptcy Developments Journal

Certain provisions of derivative trading contracts get special exemptions under the Bankruptcy Code, referred to as 'Safe Harbors,' to prevent systemic risk. The Safe Harbors seek to accomplish this goal by permitting a party to a derivative trading contract to quickly terminate and liquidate its positions. The precise parameters of the Safe Harbors remain unclear. This lack of clarity adversely affects the ability of market participants to accurately perform credit risk analyses with respect to their derivative trading counterparties and may adversely impact the ability of market participants to prepare Living Wills, as required by the Dodd-Frank Act. Similarly, it …

Using The Indicator Amino Acid Oxidation Technique To Study Threonine Requirements In Horses Fed Different Feed Compositions, Chanhee Mok

Theses and Dissertations--Animal and Food Sciences

Threonine has been reported to be the second limiting amino acid in typical equine diets, but its actual requirement has not been determined in horses. The indicator amino acid oxidation (IAAO) method has been successfully used for evaluating amino acid metabolism and requirements in animals and humans. The objective of this research was to use the IAAO method to estimate threonine requirements in mature horses fed two different feed compositions. In the first study, 6 Thoroughbred mares (4 – 16 years old) received each of 6 levels of threonine intake in a high concentrate diet, in a randomly determined order. …

Patent Law—Bringing Predictability Back With The Intracircuit Split Pronounced In Retractable Technologies, Inc. V. Becton, Dickinson & Co., 653 F.3d 1296 (2011): Claim Construction And Unpredictably Limiting The Patentee's Rights, Landon M. Reeves

University of Arkansas at Little Rock Law Review

No abstract provided.

Egads! Preservation Run Amok: A Call For Change To Arkansas's Was It Raised?, Was It Developed?, Was It Ruled On? Jurisprudence, Brian G. Brooks

University of Arkansas at Little Rock Law Review

No abstract provided.

Arbitration Agreements In Arkansas After Concepcion, John C. Williams

University of Arkansas at Little Rock Law Review

No abstract provided.

Undercover Investigations And Government Lawyers, Eric B. Estes

University of Arkansas at Little Rock Law Review

No abstract provided.

Law, Bioethics, And Medical Futility: Defining Patient Rights At The End Of Life, Frederick R. Parker Jr.

University of Arkansas at Little Rock Law Review

No abstract provided.

Mammalian Synthetic Biology: Emerging Medical Applications, Zoltan Kis, Hugo Sant'ann Pereira, Takayuki Homma, Ryan M. Pedrigi, Rob Krams

Department of Mechanical and Materials Engineering: Faculty Publications

In this review, we discuss new emerging medical applications of the rapidly evolving field of mammalian synthetic biology.We start with simple mammalian synthetic biological components and move towards more complex and therapy-oriented gene circuits. A comprehensive list of ON–OFF switches, categorized into transcriptional, post-transcriptional, translational and posttranslational, is presented in the first sections. Subsequently, Boolean logic gates, synthetic mammalian oscillators and toggle switches will be described. Several synthetic gene networks are further reviewed in the medical applications section, including cancer therapy gene circuits, immuno-regulatory networks, among others. The final sections focus on the applicability of synthetic gene networks to drug …

Criminal Law—Sentencing Juveniles—Where Do We Go From Here? Mandatory Sentencing And Retroactive Application Post-Miller. Miller V. Alabama, 132 S. Ct. 2455 (2012)., Nikki Morris

University of Arkansas at Little Rock Law Review

No abstract provided.

Contract Resurrected! Contract Formation: Common Law – Ucc – Cisg, Sarah Howard Jenkins

Law Faculty Scholarship

No abstract provided.

Law School Deans And The “New Normal.", Peter C. Alexander

Law Faculty Scholarship

No abstract provided.

The Promises And Pitfalls Of State Eyewitness Identification Reforms, Nicholas A. Kahn-Fogel

Law Faculty Scholarship

This article provides a comprehensive analysis of state-based eyewitness identification reforms, including legislative directives, evidentiary rules, and judicial interpretations of state constitutions as providing greater protection against the use of unreliable eyewitness evidence than the United State Supreme Court offered in its 1977 decision in Manson v. Brathwaite. While previous scholarship has included thorough consideration of a single state's eyewitness law, state-by-state analysis of a sub-issue in eyewitness law, and brief general surveys of state approaches to eyewitness reform, this article adds to the current body of scholarship with an in-depth evaluation of eyewitness identification law in states that have …

Toward A Critical Corporate Law Pedagogy And Scholarship, André Douglas Pond Cummings, Steven A. Ramirez, Cheryl L. Wade

Law Faculty Scholarship

In recent years, the publicly held corporation has assumed a central position in both the economic and political spheres of American life. Economically, the public corporation has long acted as the key institution within American capitalism. Politically, the public corporation now can use its economic might to sway electoral outcomes as never before. Indeed, individuals who control public firms wield more economic might and political power today than ever before. These truths profoundly shape American society. The power, control, and role of the public corporation under law and regulation, therefore, hold more importance than at any other time period.

Even …

Online Data Breaches, Standing, And The Third-Party Doctrine, Adam Lamparello

Cardozo Law Review de•novo

This Essay argues that, in the context of online data breaches, these doctrines hinder consumers from receiving full monetary compensation and do not adequately safeguard privacy rights. For example, courts frequently dismiss consumers’ suits against online service providers for lack of standing, which results in consumers bearing the cost for damages that the providers were in a position to prevent. This Essay argues that the Supreme Court should relax the standing doctrine’s “imminent harm” requirement and permit consumers to sue providers for mitigation damages. In addition, the Court should abandon the longstanding principle that citizens lose all privacy protections in …

Sketchy Lesbians: "Carol" As History And Fantasy, Patricia White

Film & Media Studies Faculty Works

Rather than a forward-looking lesbian representation, Todd Haynes's Carol, an adaptation by Phyllis Nagy of Patricia Highsmith's 1952 novel, The Price of Salt, looks to images and affective investments of the past to explore lesbian representability, the historical discourses and aesthetic codes through which desire between women can be recognized. The collaboration brings together preoccupations from Haynes's oeuvre and themes from Highsmith's that question reception of the film in terms of a happy ending and future progress. Through evocative art direction, camerawork, and star performances, the film invites the viewer to share the perspective of Therese (Rooney Mara), …

Hitchhiking The Labyrinth, Tom Gage

The Journal of the Assembly for Expanded Perspectives on Learning

James Moffett’s best friend recalls Moffett’s enduring influence on his own extraordinary career, as well as Moffett’s substantial contributions to AEPL.