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Loss Of Multidrug Resistance-Associated Protein 1 (Mrp1/Abcc1) Potentiates Doxorubicin-Induced Cardiotoxicity In Mice, Wei Zhang

Theses and Dissertations--Toxicology and Cancer Biology

Doxorubicin (DOX) is a broad-spectrum and effective chemotherapeutic agent, but its use in oncologic practice is limited by dose-dependent cumulative cardiotoxicity. DOX-induced cardiotoxicity is in large part due to its ability to cause oxidative stress. Multidrug resistance associated protein 1 (MRP1/ABCC1) is a member of the ATP-binding cassette (ABC) transporter superfamily. By effluxing a wide variety of endogenous and exogenous substrates, Mrp1 plays important physiological roles in multiple tissues and also protects normal tissues against toxicants. However, the role of MRP1 in heart is largely unknown.

The role of Mrp1 in DOX-induced cardiotoxicity was investigated in Mrp1 null (Mrp1-/-) and …

Who Commits To The Rule Of Law? Constrained Government And Foreign Direct Investment In Postcommunist States, Michael Touchton

Political Science Faculty Publications and Presentations

Research linking credible commitments to the rule of law in terms of property rights and contract enforcement is a hallmark of recent efforts to explain economic growth and development. However, many postcommunist states have had difficulty making such commitments and spurring growth. Many argue political polarization prevents states from reforming laws and protecting property rights in some countries whereas single-party governance renders state promises incredible in others. I analyze pooled cross-sectional time-series data for twenty-four postcommunist countries and provide evidence effective constraints among elected officials act as democratic commitment mechanisms rendering government policies credible.

Contracting, Contesting, And Co-Optation: Civil Society Organizations’ Strategies Under New Institutional Arrangements In Brazil, Brian Wampler, Michael Touchton

Political Science Faculty Publications and Presentations

Civil society has exploded in Latin America as democratization has continued over the last 30 years. Civil society organizations (CSOs) are thought to improve governance and oversight and to increase social capital. Nonetheless, we have limited knowledge about what motivates CSOs’ political strategies, which include participating in formal political institutions, attending demonstrations, and providing services. We build knowledge here by evaluating data from a unique survey of nine hundred CSOs across seven Brazilian cities. Our findings showcase several parallel processes: poorer CSOs continue to rely on the state and actively participate in political processes despite protesting at greater rates than …

From A-Town To Atl: The Politics Of Translation In Global Hip Hop Culture, Holger Droessler

Journal of Hip Hop Studies

This article examines the linguistic and cultural tensions in global Hip Hop culture through an analysis of the performance of Gsann, an emcee from the Tanzanian Hip Hop crew X Plastaz, at the 2009 Black Entertainment Television (BET) Hip Hop Awards in Atlanta. Gsann's rhymes in Swahili, his emphasis on religion, and his global travels distinguished him from his African American colleagues in the cipha. At the same time, the decision by the BET producers to translate Gsann's Swahili rhymes into English has to be seen within the longer history of cultural and linguistic politics in Tanzania and the United …

Impact Of A Science Methods Course On Pre-Service Elementary Teachers' Knowledge And Confidence Of Teaching With Scientific Inquiry And Problem-Based Learning, L. Y. Whiteman, T. M. Walker, T. L. Spencer

Journal of Mathematics and Science: Collaborative Explorations

The purpose of this study was to measure the impact of an elementary science methods course on pre-service teachers' knowledge and confidence of teaching with inquiry and problem-based instructional strategies. Changes in pre-service teachers' knowledge and confidence were measured before and after completing the course activities using a pilot survey entitled "Science Pedagogical Content Knowledge & Confidence (PCKC) Survey." An integrated lecture/laboratory elementary science methods course engaged participants with hands-on activities designed to increase their pedagogical content knowledge: including theory, planning and implementation of inquiry, and problem-based learning. The results indicated that pre-service teachers' knowledge and confidence improved as a …

The Rescission Doctrine: Everything Old Is New Again, Allen Sparkman

American University Business Law Review

No abstract provided.

The Clean Power Plan: An Introduction To Cooperative Federalism In Energy Regulation, Tina Calilung

American University Business Law Review

No abstract provided.

Condemning A Residential Mortgage Loan: Is It An Extraterritorial Taking?, Michael M. Sandez

American University Business Law Review

No abstract provided.

Are Bilateral Investment Treaties And Free Trade Agreements Drafted With Sufficient Clarity To Give Guidance To Tribunals?, Benard Hanotiau

American University Business Law Review

No abstract provided.

The Interface Between Arbitration And The Brussels Regulation, Filip De Ly

American University Business Law Review

No abstract provided.

Challenges To The Credibility Of The Investor-State Arbitration System, Michael Nolan

American University Business Law Review

No abstract provided.

The Future Of International Arbitration In Central And Eastern Europe, Wojciech Sadowski

American University Business Law Review

No abstract provided.

A Tale Of Two Cities: The Regulatory Battle To Incorporate Short-Term Residential Rentals Into Modern Law, Dana Palombo

American University Business Law Review

No abstract provided.

Salient Features Of International Commercial Arbitration In East Asia: A Comparative Study Of China And Japan, Fan Kun

American University Business Law Review

No abstract provided.

A Modest Proposal For Preventing Multipartite Arbitrations From Being A Burden To The Parties And For Making Them Beneficial To The Parties, Alexis Martinez, Rostislav Pekar

American University Business Law Review

No abstract provided.

The Extension Of The Arbitral Agreement To Non-Signatories In Europe: A Uniform Approach?, Eduardo Silva Romero, Luis Miguel Velarde Saffer

American University Business Law Review

No abstract provided.

Going Green: Legal Considerations For Marijuana Investors And Entrepreneurs, Frank Robison

American University Business Law Review

No abstract provided.

Industrial Hemp: Canada Exports, United States Imports, Courtney Moran

Fordham Environmental Law Review

No abstract provided.

The Intersection Of Federally Regulated Power Markets And State Energy And Environmental Goals, Julia Sullivan

Fordham Environmental Law Review

No abstract provided.

The Therapeutic Targeting Of Folate Receptor Alpha Positive Tumors Via Folate Receptor Selective Novel 5- And 6- Substituted Pyrrolo [2,3-D]Pyrimidine Antifolates", Shermaine Kimberly Mitchell-Ryan

Wayne State University Dissertations

Ovarian Cancer is the fifth leading cause of cancer-related death of women in the United States. Epithelial Ovarian Cancer (EOC) constitutes 85-90% of malignancies within the ovary, with an alarming majority of these cases diagnosed at advanced stage. While most patients are initially highly responsive to the current treatment standard, there is a very high probability that they will recur with a drug resistant fatal disease. Currently there is no validated comprehensive model of disease progression for ovarian cancer, although tremendous progress has been made in understanding the origin of this disease and a putative precursor lesion has been identified …

Proteasome Inhibition As A Potential Anti-Breast Cancer Therapy: Mechanisms Of Action And Resistance-Reversing Strategies, Rahul Rajesinh Deshmukh

Wayne State University Dissertations

AMPK activation and Ubiquitin Proteasome System (UPS) inhibition have gained great attention as therapeutic strategies for the treatment of certain types of cancers. While AMPK serves as a master regulator of cellular metabolism, UPS regulates protein homeostasis. Although the crosstalk between them is suggested, the relationship between these two important pathways is not very clear. We observed that proteasome inhibition leads to AMPK activation in human breast cancer cells. We report that a variety of proteasome inhibitors activate AMPK in all of the tested cancer cell lines. Our data using Liver Kinase B1 (LKB1)-deficient cancer cells suggests that proteasome inhibitor-induced …

Identification Of Fetal Genomic Copy Number Deletions Associated With Preeclamptic Mothers In The Caucasian Population, Tze-An Yuan

Public Health Theses

Genetic determinants that are associated with preeclampsia still remain elusive

nowadays, which might have resulted from limited understanding of the underlying

pathogenesis mechanisms and the fetal contributions. By using genome-wide association study approach, we identified 2 candidate copy number deletions of the highest odds ratio ranking on chromosome 1 and 19, from 283 US white babies born by the mothers with preeclampsia. Based on the molecular and biological functions of the genes entailed the deleted regions, which contain CTSK, ARNT, and ACTN4, we proposed that these two candidate genomic deletions might be associated with preeclampsia. In a further attempt to …

Evaluation Of A U.S.-Based Training Program To Promote Task-Sharing In Maternal Mental Health, Emily Rosemary Goettsche

Public Health Theses

Abstract

Objective: This thesis evaluates the acceptability and feasibility of training community mental health workers in mental health in community settings. The specific aims of this study are:

(1) to determine whether community health worker trainings in mental health delivered in the community by non-researchers can be evaluated using a structured research protocol and

(2) to assess whether the community mental health worker training improves the knowledge, behaviors, and attitudes of the people who complete the training.

Background: Mental health task-sharing interventions targeting mothers in the United States have minimal research regarding efficacy and feasibility. This thesis describes the development …

The Sum Of Its Parts: The Lawyer-Client Relationship In Initial Public Offerings, Jeremy Mcclane

Faculty Articles and Papers

No abstract provided.

Administering Section 2 Of The Voting Rights Act After Shelby County, Douglas M. Spencer, Christopher S. Elmendorf

Faculty Articles and Papers

Until the Supreme Court put an end to it in Shelby County v. Holder, section 5 of the Voting Rights Act was widely regarded as an effective, low-cost tool for blocking potentially discriminatory changes to election laws and administrative practices. The provision the Supreme Court left standing, section 2, is generally seen as expensive, cumbersome, and almost wholly ineffective at blocking changes before they take effect. This Article argues that the courts, in partnership with the Department of Justice, could reform section 2 so that it fills much of the gap left by the Supreme Court's evisceration of section 5. …

The Psychodynamics Of Sexual Choice, Anne Dailey

Faculty Articles and Papers

The right of sexual autonomy now occupies a central place in the scheme of constitutional liberties. Consensual sexual relations, including fornication, adultery, and sodomy, are understood to lie beyond the reach of law 's regulatory power. Yet as described in this Article, some sexual encounters by their very nature are likely to engage unconscious psychological processes that involve troubling levels of vulnerability and coercion. Drawing on psychoanalysis, this Article proceeds by examining three relationships that raise heightened concerns about unconscious impairments in sexual choice. Part I investigates the way in which adult incest may trigger unconscious feelings of submission on …

Notes Toward An Understanding Of The U.S. Market In Foreign Ll.M. Students: From The British Empire And The Inns Of Court To The U.S. Ll.M., Bryant G. Garth

Indiana Journal of Global Legal Studies

Mindie Lazarus-Black and Julie Globokar's article on "Foreign Attorneys in U.S. LL.M. Programs: Who's In, Who's Out, and Who They Are" uses interviews, LL.M. student observations, and actual admissions committee documents from one Midwest and one East Coast law school to confirm the tremendous growth of those programs over the past two decades in the United States and indicate who makes the journey to the United States; how foreign LL.M. candidates pitch themselves to admissions committees; how those admissions committees evaluate candidates; and what candidates expect from LL.M. programs. The voices that come through are quite compelling. We now know …

The Greek Debt Crisis: The Need For "Heroic" Economic Policy Reforms In The European Economic And Monetary Union, Peter Robbins

Indiana Journal of Global Legal Studies

Greece is in the midst of a devastating economic and financial crisis that the European Union has been trying ardently to resolve since the default of Lehman Brothers in 2008. A significant number of other European Union (EU) Member States are also in crisis due to various state-level economic and monetary causes. Meanwhile, the European Union has consistently used the existing treaty articles and legislation within its competence to impose traditional and homogenized austerity measures on highly indebted Member States, most notably Greece. In sum, the European Union has zealously advocated for fiscal conservatism driven by the German "diber-fear" of …

Using A Community-Based Strategy To Address The Impacts Of Globalization On Underwater Cultural Heritage Management In The Dominican Republic, Lydia Barbash-Riley

Indiana Journal of Global Legal Studies

This Note addresses the management of the Underwater Cultural Heritage (UCH) in the Dominican Republic as a case study of the effects of two aspects of globalization on cultural and environmental resource management in the developing world: the international convergence of values and the horizontal delegation of state power to private actors due to economic constraints. This Note posits that even as the global community of states moves toward a consensus on the ethical management of the UCH, this convergence combined with the global trend of horizontal delegation may incentivize some lesser-developed countries to deal with the economic pressures of …

Toward Permanence: Addressing The Need For Accessible Premarital Care For Deaf Couples, Peter Christopher Myers

All Electronic Theses and Dissertations

Deaf people in America have become increasingly recognized in recent years as a distinct community. While Christianity within the Deaf community has a recorded history dating back some five hundred years, little is known regarding pastoral care for Deaf people and in particular, guidance in marriage preparation. In spite of the plethora of research on marriage preparation, little attention has been paid to Deaf couples and marriage preparation-its efficacy for them in enhancing marital satisfaction and avoiding divorce. This project addressed the inaccessibility of premarital-care resources in the church for Deaf couples whose first language is American Sign Language (ASL). …