Digital Commons Network^™

Characterization Of The Role Of Rsd-6, A Tudor Domain Protein, In Antiviral Rnai Pathway In Caenorhabditis Elegans, Krishna Prasad Dahal

LSU Doctoral Dissertations

RNA interference (RNAi) triggered by virus produced dsRNA intermediate offers robust innate immunity against invading viruses in plants, insects and animals. Caenorhabditis elegans has been extensively used as a model organism to study host virus interaction. Recently, a forward genetic screen identified RNAi spreading deficient-6 (RSD-6), a Tudor domain protein, as a key component in antiviral RNAi pathway against Orsay virus in C. elegans but its contribution in the pathway remained unclear. Here, we generated a rsd-6 null allele using CRISPR-Cas9 genome editing, crossed it with other known RNAi mutants and analyzed Orsay virus replication in them and in combination …

Constitutional Futurism As Pedagogy, Jeremiah Chin

Seattle University Law Review

Constitutional Law has transformed from a course on history to a discussion of current events. Cases like Students for Fair Admissions v. Harvard College, Dobbs v. Jackson Women’s Health Organization, and Loper Bright Enterprises v. Raimondo reveal that the study of constitutional law is not a static, or even linear, discussion of constitutional text and history. Law is a shifting, changing enterprise that reflects social constructions of power, authority, and identity. How do we teach, learn, and understand constitutional law that is so laden with history, riddled with theories of consistency and adherence to precedent, but ultimately subject …

Language Of Love: Kafka’S Affective Meaning In Briefe An Milena, Kafka Aisyah Triny, Julia Wulandari

International Review of Humanities Studies

Franz Kafka is known for his twisted literature filled with dark atmosphere and word choices, however when it comes to writing letters to his muse, Milena, he uses words unknown to him. He expresses his barest soul to her using word choices that indicate someone who is amazed. For a person like Kafka, love is not all about complementing word choices and emotions, seen by his internal battles with himself and uncertainty regarding the topic of love. This research will use Geoffrey Leech’s semantic framework along with Monica Schwarz and Jeannette Chur’s Wortfeld theory. The study aims to examine Kafka’s …

Effective Strategies For Deterring Unethical Behavior In U.S. Financial Institutions, Samuel Akinlade Sanni

Walden Dissertations and Doctoral Studies

Unethical employee behavior in U.S. financial institutions continues to erode organizational trust and firms’ brand reputation. Leaders of financial institutions are concerned that unethical employee behavior can negatively impact firms’ profitability, competitiveness, and sustainability. Grounded in Kaptein’s corporate ethics virtue (CEV) model, the purpose of this qualitative pragmatic inquiry study was to explore how organizational ethical cultures influence employees’ behaviors. Data were collected through semistructured interviews with a sample of eight leaders in New York financial institutions, with a minimum of 5 years of successful experience in building a positive ethical environment, and by analyzing publicly available documents to support …

Factors Influencing Information And Accessibility Of Tuberculosis Prevention Services Among Nomadic Fulani And Host Communities, Nigeria, Abolaji Azeez, Kabiru Salami

Journal of Social, Behavioral, and Health Sciences

Despite efforts to curtail tuberculosis (TB) in Nigeria, the country has not yet attained the global target. This study explored the dynamics of access to information about TB control and prevention among nomadic Fulani and their host communities. We used a mixed-methods approach and multistage sampling technique to recruit 812 respondents for the survey, and we conducted 18 in-depth interviews across six local government areas. The results indicated generally low access to TB information and services, with only 2% of nomadic Fulani engaging in TB prevention activities compared to 6.7% of host community members. Yoruba respondents had significantly higher odds …

Cyber Attacks On Government-Managed Systems: A Social Epistemology Perspective, Aurelia Bunga Anggun Putri Romavella, Fristian Hadinata

International Review of Humanities Studies

This article examines cyberattacks on government-managed systems from the perspective of social epistemology. The development of information technology, particularly the internet, has changed the way governments operate and interact with the public. However, these changes have also created new vulnerabilities to cyberattacks that can disrupt public services, undermine public trust and threaten national security. Social epistemology, with its focus on how knowledge and beliefs are constructed and disseminated in society, provides a useful analytical framework for understanding these cyberattack dynamics. This article examines how cyberattacks affect the production, distribution and validation of knowledge in the context of governance. By analyzing …

The Influence Of Colonialism On The Development Of Religious Life In Timor Leste, Abdul Kadirsyam Salampessy, Rahadjeng Pulungsari Hadi

International Review of Humanities Studies

Timor-Leste is the youngest country in the world with unique religious dynamics. The Catholic population increased rapidly after independence, while the Muslim population decreased drastically due to political dynamics. The presence of Mari Alkatiri, an Arab-descended Timorese Muslim who became Prime Minister (PM) twice, is a depiction of the presence of Islam in a Catholic-majority country. The long history of colonialism in Timor-Leste has greatly influenced the landscape of religious life there. In its development, the people of Timor-Leste live harmoniously and democratically.

This journal uses a qualitative research method that focuses on the social and cultural phenomena of the …

Association Between Sociocultural Factors, Obesity, And Depression In The Hispanic/Latino Population, Maia Junco

Walden Dissertations and Doctoral Studies

The increasing prevalence of obesity and mental health disparities among Hispanic/Latino populations in the United States underscores the need to understand how sociocultural factors shape physical and psychological health. The purpose of this study was to examine how acculturation, diet quality, and fiber intake affect BMI and depressive symptoms over time. The study was guided by acculturation theory and the biopsychosocial model. The study used longitudinal secondary data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) with a sample of N=8,816, including adults who completed examination visits, 1 (2008–2011) and 2 (2014–2017). Path analysis was conducted to assess direct …

Contemporary Turkish Foreign Policy In Africa: Decoding The Motivations Behind Turkish-Cameroon Relations, Tekang P. Kwachuh

The World Research of Political Science Journal

In recent years, cotemporary Africa has witnessed an influx of new actors such as Russia, India, Iran, and of course Türkiye. The Republic of Türkiye has joined the old cadres in the likes of US, France, Germany to cement it footprints on the continent. Meanwhile, countries like France are experiencing anti-French sentiments that have culminated to the expulsion of French troops and terminating French economic interests especially in Sahel region in Africa. Turkeys global footprint in Africa, particularly in North Africa, can be viewed via its Ottoman past. The countrys foreign policy, particularly in the late 1990s and in the …

The Impact Of Weaponizing Womens Political Rights On Democratic Bscksliding: A Case Study Of Sheikha Hasina (Pm Of Bangladesh), Nouran Mousa Abdelaziz

The World Research of Political Science Journal

This paper examines how authoritarian leaders can strategically weaponise womens political rights to keep power and conceal democratic backsliding, using Prime Minister Sheikha Hasinas administration in Bangladesh as an example. Using the historical institutionalism framework, the paper investigates how Hasinas government fostered gender-based legislation and representation while eroding democratic institutions. Through a qualitative analysis of legislation amendments, political discourse, and institutional changes from 2019 to 2024, the study demonstrates how symbolic empowerment of women was used to legitimise a more autocratic state. The findings show that perceived gender progress was frequently utilised to cover up both internal and foreign criticism, …

From Orwel’S 1984 To Assad’S Syria: When Dystopian Fiction Turns Political Reality, Shahd Gadallah

The World Research of Political Science Journal

As we approach the 76th anniversary of George Orwell’s 1984 on June 8th, the novel is a critique of tolerationism, illustrating a fictional world where propaganda, surveillance, and political repression sustain an all-controlling regime. The novel’s theme resonates with real world authoritarian governments, particularly the recently disposed Assad regime in Syria. This article explores how the governance tactics of the Assad regime such as historical revisionism, mass surveillance, state-controlled propaganda and the cult of leadership mirror the Orwellian fictional dystopian mechanisms. By comparing key elements of Orwell’s 1984 with the political atmosphere under decades of Assad regime, the article argues …

The Russian Ukraine War’S Impact On The Emergence Of Multipolar World Order, Lara Abdelrazik

The World Research of Political Science Journal

The United States emerged as the sole super power country after the cold war and the dissolution of the Soviet Union 1991, and its dominance was particularly significant in Europe, and Middle East countries where America first ideology controlled most of their decisions. However, the United States dominance and the fact of having a sole power country to control the world is no longer as effective as it was before the Russian Ukraine war. Russia became a threat to the unipolar system, and it encouraged the emergence of a new multipolar system after the war alarmed United States that China, …

Social Media As A Political Actor: Analyzing Their Roles During Conflicts, Mohammed Wahhab Abbood

The World Research of Political Science Journal

The research explores the complex roles that social media play as political actors during conflicts, focusing on their influence on public opinion, mobilization efforts, and information dissemination. This study addresses three main research questions related to the mechanisms of public opinion influence, the role of social media in mobilizing social movements, and their impact on information dissemination in conflict scenarios in the Middle East and the war in Gaza. Using a qualitative methodology grounded in theoretical analysis, it uncovers critical insights into how algorithmic amplification shapes public discourse, the diverse effectiveness of digital mobilization, and the challenges of misinformation. The …

Looking South The Moroccan Dream: Foreign Policy Theoretical Perspectives And Morocco’S Turn Towards Mother Africa, Mariam Bensaoud

The World Research of Political Science Journal

This work examines Morocco’s unprecedented foreign policy choice toward sub-Saharan Africa under the auspices of liberalism and realism in foreign policy analysis frameworks. It argues that while Morocco’s foreign policy toward the region is one of liberal character, that is market and business oriented, it is still aimed at realist grounds. In other words, while liberalism helps extract Morocco’s liberal motives for choosing Sub-Saharan Africa, it does not provide the whole picture. Considering Morocco’s national integrity and security objectives, the Western Sahara issue provides explanation for the geopolitical and strategic motives behind this foreign policy for which the realist model …

Cyberterrorism: A New Form Of Terror, A Misunderstood Crime Or A Free-Pass For Privacy Invasion? Morocco As A Case Of Study, Nada Naji

The World Research of Political Science Journal

The phenomenon of cyberterrorism remains a contentious topic among scholars, with ongoing debates regarding its very existence. Questions arise as to whether cyberterrorism constitutes a distinct crime or if it is merely an exaggerated and politically manipulated form of cybercrime. This discourse introduces several critical issues, the first being the challenge of defining terrorism itself, a concern that has persisted since the inception of the term. Additionally, there exists a significant distinction between cyberterrorism and cybercrime, necessitating a clear understanding of the boundaries that separate the two. Another pressing inquiry involves evaluating the potential threats posed by cyberterrorism and the …

Diplomacy Of Palestinian Civilizational Confrontation In Light Of A Changing World, Morsi Abdel Al Kareem Abdel Razeq

The World Research of Political Science Journal

This study aims to clarify the current changing global situation with its composition, complexities, details, daily crises, and its repercussions on the Palestinian issue, which requires Palestinian civilizational diplomacy to review the Palestinian struggle path, evaluate its performance and results, and review its work methods and strategies to deal with the dynamics of transformations and complex interactions, in a way that protects legitimate Palestinian rights. And it contributes to preserving the specificity of the Palestinian issue by preserving peace, peace and coexistence between religions, protecting cultural and religious property, and rejecting terrorism regardless of its perpetrators, in order to achieve …

Recovery-Oriented Dog Intervention (Rodi): An Autoethnography On How A Dog Made Us Change Our Perception Of Recovery And Flatten Our Ontologies, Knut Tore Sælør, Rose-Marie Bank

The Qualitative Report

Allegedly named after a dog show judge, our late dog Rodi was never a Recovery-Oriented Dog Intervention (RODI). Through collaborative-duo-autoethnography, we explore how our mundane co-existence with Rodi has influenced our perspectives on health struggles, recovery, ontology, and what really matters when life becomes difficult, and push comes to shove. We have shared texts describing our memories of how Rodi entered and influenced our lives. Through our collaborative writing we have discovered similarities and differences. Drawing inspiration from philosophy, posthumanism, and new materialism, we argue that our four-legged companion not only changed our everyday lives, but also our perspectives on …

Engaging For A Sustainable Manufacturing: The Power Of Adaptive Leadership In Industry 5.0, Rizwana Rasheed, Aamir Rashid, Abdul Hafaz, Rashid Hashmi

Publications and Research

In today’s highly competitive and rapidly evolving business environment, organizations must continuously adapt to technological advancements and market volatility. This study examines how adaptive leadership influences sustainable manufacturing through employee engagement, with employee wellbeing as a mediator and mindfulness as a moderator. Using data from 1,388 U.S. manufacturers and PLS-SEM analysis, the research confirms that adaptive leadership positively impacts sustainable manufacturing through engaged employees and enhanced wellbeing. Additionally, employee mindfulness significantly strengthens the relationship between adaptive leadership and engagement. These findings highlight the importance of leadership styles that foster employee participation and mental wellbeing in achieving long-term manufacturing sustainability. The …

Estimating Galactic Structure Using Galactic Binaries Resolved By Space-Based Gravitational Wave Observatories, Shao-Dong Zhao, Xue-Hao Zhang, Soumya Mohanty, Màrius Josep Fullana I Alfonso, Yu-Xiao Liu, Qung-Ying Xie

Physics & Astronomy Faculty Publications

Space-based gravitational wave detectors, such as the Laser Interferometer Space Antenna (LISA) and Taiji, will observe GWs from O(108) galactic binary systems, allowing a completely unobscured view of the Milky Way structure. While previous studies have established theoretical expectations based on idealized data-analysis methods that use the true catalog of sources, we present an end-to-end analysis pipeline for inferring galactic structure parameters based on the detector output alone. We employ the GBSIEVER algorithm to extract GB signals from LISA Data Challenge data and develop a maximum likelihood approach to estimate a bulge-disk galactic model using the resolved GBs. We introduce …

The Psychological And Social Experiences Of Hospitalized Patients With Covid-19: A Qualitative Study, Fatma Kantaş Yılmaz, Zeynep Koca, Zuhal Kunduracılar

Makara Human Behavior Studies in Asia

Individuals infected with coronavirus disease 2019 (COVID-19) have experienced torrents of problems associated with the pandemic, impairing their health, mental, social, and economic conditions. This study aimed to determine the psychological reactions and emotions of patients with COVID-19 infection and the social consequences during hospitalization. The current study used a qualitative and phenomenological design at a training and research hospital in Istanbul, Turkey. The study sample included 17 patients (41.6 ± 16.5 years) who had been discharged after COVID-19 treatment. The gathered information was classified into two main domains (social and psychological) and relevant themes and subthemes using a content …

Exploring Giftedness And The Gifted Learner In Education And Beyond: An Autoethnographic Study With Critical Friends, Katrina Reynen-Woodward, Penny N. Round Dr, Pearl Subban, Edwin Creely

The Qualitative Report

The concept of giftedness is complex, contested and evolving and may be thus frustratingly challenging to apply in practice. One area of emerging research is understanding the personal experiences of those who identify as gifted in order to better represent the myriad culturally diverse conceptions of giftedness that evolve over a lifetime. In this article, I employ an autoethnographic approach to explore aspects of my adult identity as an atypical learner. This journey unfolds in crafted vignettes that reveal the complexities and multi-dimensionality of my learning and are analysed using Gagné’s Differentiated Model of Giftedness and Talent (DMGT). As I …

Single-Cell Transcriptomics Of Ventral Forebrain Progenitors Identifies Evf2 Enhancer Lncrna-Enhancer Gene Guidance Through Direct Rna Binding And Rnp Recruitment Domains, Edward Li, Abhijit Chakraborty, Sara J Kohtz, Ivelisse Cajigas, Laura Hinojosa-Gonzalez, Fion Shiau, Ryan Bertossi, Robert J Vassar, Jack A Kessler, Ferhat Ay, Brian S Clark, Jhumku D Kohtz

2020-Current year OA Pubs

During mouse embryonic brain development, the Evf2 ultraconserved enhancer (UCE) lncRNA guides the Dlx5/6UCE to ~129 sites across chr6. However, previous work identified only 4 transcriptionally regulated targets associated with Evf2-Dlx5/6UCE-gene guidance, raising questions about the significance of Evf2-regulated Dlx5/6UCE-gene interactions. Here, single-cell transcriptomics reveal far greater alignment between Evf2-Dlx5/6UCE-gene guidance and transcriptional regulation than previously reported. Evf2 divides chr6 into short-range ( < 10 Mb distant), activated genes, and long/super-long-range (10-129 Mb distant), repressed genes, identifying seizure regulating genes in the embryonic subventricular zone that predict adult phenotypes. Evf2-regulated Dlx5/6UCE-gene distances and directions (closer to or further from gene targets) can be decoupled from gene target transcriptional effects. Evf2 regulates Evf2-ribonucleoprotein (RNP) binding in a combinatorial manner to key regulatory sites, including chr6 Evf2-Dlx5/6UCE-gene guided sites, Evf1/2 RNA-directly bound sites (RBSs), and inter-chromosomal HiC looping interactions. RBSs divide chromosomes into multi-megabase domains enriched for Evf2-regulated RNP recruitment, transcription factor motifs, and HiC looping interactions. Together with Evf2-controlled homeobox motif recognition at Evf2-RNP recruitment sites and transcription factor motif enrichment in RBSs with DNA identity, this work supports direct roles for Evf2 in enhancer-gene guidance and transcriptional regulation, with the potential for both site-specific and chromosomal domain specific RNP recruitment.

The Cost Of Showing Up, Lauren Roberts

NULR Online

No abstract provided.

Transformation With Genes To Improve Lipid Production And Barcoding To Identify Unknown Algal Species, Michelle T. Rada

Theses and Dissertations

With the rising demand for alternative fuels, algal-based biofuels are a promising, sustainable source that meets commercial interest while producing lower greenhouse gas emissions compared to fossil fuels. This thesis explored two studies, evaluating microalgae for their future potential in lipid yield for biofuel production.

The first study involved developing a cost-efficient electroporation protocol that allowed for the genetic transformation of Chlamydomonas reinhardtii using the pChlamy_4 vector, which supports future cloning of genes to enhance lipid production. Parameters affecting DNA uptake and integration into algal genomes were studied: the effect of cell density, the settings of the electroporation device, and …

A Rare Case Of Rapidly Progressing Merkel Cell Carcinoma, David Sau Ting Jain, Omer Riyadh, Kayla Tran, Nguyen L. Ngo, Dei-Wook Kang

Student Publications

Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine tumor, known for its rapid progression and poor prognosis. It most commonly affects elderly and immunocompromised individuals, with variable clinical presentations that can make diagnosis challenging. MCC is often mistaken for other skin malignancies, such as basal or squamous cell carcinoma, or even benign skin lesions. Early diagnosis is critical to initiate appropriate treatment, typically involving surgery, radiation, and immunotherapy. This report describes a 66-year-old man diagnosed with MCC with regional lymph node involvement. Immunotherapy was started promptly; however, within a year, the disease progressed to the mediastinum, involving the esophagus …

Building Community In The Workplace, Jawahir Javaid

POC in LIS Summit

Using research in relational sociology and personal experience, I would like to present on how relational interactions help prevent alienation and isolation in the workplace. I chose to work at an academic library due to its commitment to Diversity, Equity, and Inclusion (DEI), yet the absence of empathy and mutual respect in workplace culture made it increasingly difficult to feel valued. Department transactions felt dehumanizing and exploitive, and DEI principles felt abstract rather than lived experiences. I turned to relational sociology for a broader understanding of why I felt excluded in a work environment priding itself in DEI values.

Relational …

Left Atrial Dysfunction Is An Early And Transitional Driver In The Development Of Heart Failure With Preserved Ejection Fraction, Jasmine Matsuda

Summer Research Internship Program

No abstract provided.

Familial Lung Cancer: A Comparative Study On Epidemiological And Clinical Characteristics, Anne George

Summer Research Internship Program

No abstract provided.

The Efficacy Of Rj-22, Rj-23, And At-13 Against The Mcf7-Y537s Mutation Of Erapositive Breast Cancer Cells, Sihyoung Kim

Summer Research Internship Program

No abstract provided.

Abstract Book (Pdf), School Of Medicine

Summer Research Internship Program

Abstract Book for the 2025 Summer Research Internship Program. Participants are listed alphabetically by last name.