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Ligand-Receptor Interactions Induce And Mediate Regulatory Functions Of Batf3+ B Cells, Funan He, Weiwei Luo, Jingwei Wang, Maria J Fernandez, Uday P Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E Rivera, Harshita B Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R Sareddy, Hong Zan, Yue Li, Evelien M Bunnik, Guangming Zhong, Christopher A Hunter, Ross M Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J Curiel, Yan Xiang, Ratna K Vadlamudi, Paolo Casali, Zhenming Xu Oct 2025

Ligand-Receptor Interactions Induce And Mediate Regulatory Functions Of Batf3+ B Cells, Funan He, Weiwei Luo, Jingwei Wang, Maria J Fernandez, Uday P Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E Rivera, Harshita B Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R Sareddy, Hong Zan, Yue Li, Evelien M Bunnik, Guangming Zhong, Christopher A Hunter, Ross M Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J Curiel, Yan Xiang, Ratna K Vadlamudi, Paolo Casali, Zhenming Xu

Faculty, Staff and Student Publications

B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27–IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 …


Representation, Dynamics And Optimization Of Physical Structures, Fan Feng Oct 2025

Representation, Dynamics And Optimization Of Physical Structures, Fan Feng

Dartmouth College Ph.D Dissertations

Computational tools play a vital role in structural analysis and design, enabling engineers and researchers to optimize performance, reduce material usage, and explore novel configurations across solids and fluids. Capturing, analyzing, and optimizing these structures while balancing efficiency, stability, and adaptability remains a central challenge. This thesis proposes three complementary methods that advance representation, simulation, and optimization. We present an impulse (gauge) fluid formulation that utilizes the impulse gauge variable to reduce numerical diffusion and better preserve coherent flow features such as vorticity at practical resolutions. We introduce a differentiable Voronoi representation for cellular solids that provides smooth implicit boundaries …


College For All And The Postsecondary Experiences Of Rural First-Generation College Students: Patterns Of Alignment With A Predominant Master Narrative, Andrew D. Coppens, Sarah Jusseaume, Jayson O. Seaman, Cindy L. Hartman, Erin H. Sharp Oct 2025

College For All And The Postsecondary Experiences Of Rural First-Generation College Students: Patterns Of Alignment With A Predominant Master Narrative, Andrew D. Coppens, Sarah Jusseaume, Jayson O. Seaman, Cindy L. Hartman, Erin H. Sharp

Faculty Publications

The aim of this study was to understand the experiences of rural, first-generation college (RFGC) students in relation to dominant culturally normative expectations about postsecondary educational and workforce trajectories. The study adopted patterns of engagement with a master narrative as both a conceptual framework and unit of analysis, examining both biography and cultural ecologies as well as highlighting agency in the lives and choices of study participants. Evidence is drawn from 4 in-depth narrative interviews with each of 14 RFGC students, conducted both at school and students’ homes, from rural and small-town communities. Results show that a master narrative of …


Lessons Learned: Katalin Mérő, Salil Gupta Oct 2025

Lessons Learned: Katalin Mérő, Salil Gupta

Journal of Financial Crises

Between 1990 and 2010, Katalin Mérő served in various roles for Hungary’s central bank, Magyar Nemzeti Bank, and the Hungarian Financial Supervisory Authority. She led the Economics, Risk Assessment, and Regulatory Directorate between 2005 and 2019 and was the deputy head of the Financial Stability Department. She was also a member of the Joint Board of Appeal of European Supervisory Authority from 2011 to 2021. Mérő graduated from the Corvinus University of Budapest and received a PhD in 2005 from the Budapest University of Technology and Economics. Since 2016, she has served as an associate professor at Budapest Business School, …


Stressing The Stress Tests, Natasha Sarin, Til Schuermann Oct 2025

Stressing The Stress Tests, Natasha Sarin, Til Schuermann

Journal of Financial Crises

In the spring of 2023, Silicon Valley Bank, Signature Bank, and First Republic Bank failed, owing to predictable rate hikes by the Federal Reserve. It’s clear from these recent events that the current US stress-testing system is ill-suited to mitigate risk associated with the banking system, especially when looking at smaller regional banks that aren’t subjugated to annual stress testing. Stress testing as a regulatory tool is also exposed to significant legal risks following recent Supreme Court jurisprudence that draws into question the viability of the status quo. Today, regulators and other interested parties must change tacks to craft a …


W&L Law Fall Scholarship Celebration 2025, Andrew Christensen, Michelle Cosby, Brandon Hasbrouck, Jennifer Mitchell, Melanie D. Wilson Oct 2025

W&L Law Fall Scholarship Celebration 2025, Andrew Christensen, Michelle Cosby, Brandon Hasbrouck, Jennifer Mitchell, Melanie D. Wilson

Library Events

On October 9, 2025, the Washington and Lee Law Library hosted the fifth W&L Law Fall Scholarship Celebration. The event was co-sponsored by the Frances Lewis Law Center and took place in the Law Library's main reading room from 5:00 to 7:00 p.m.

On display were dozens of scholarly articles, books, chapters, and court briefs authored by the W&L Law faculty and student body between October 2022 and October 2025. Additional works were accessible online via QR codes to W&L Law Scholarly Commons institutional repository. A selection of vintage scholarship by former W&L Law professors was also on display, courtesy …


2017 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University Oct 2025

2017 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.


2016 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University Oct 2025

2016 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.


2014 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University Oct 2025

2014 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.


2012 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University Oct 2025

2012 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.


2009 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University Oct 2025

2009 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.


2007 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University Oct 2025

2007 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.


2006 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University Oct 2025

2006 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.


The Tax Trench Deepens, Tracey M. Roberts Oct 2025

The Tax Trench Deepens, Tracey M. Roberts

Florida Tax Review

Congress, long divided, has been in gridlock for decades. The result has been regulatory ossification. Existing statutes lack the flexibility to manage the country’s many technological, social, environmental, sectoral and market challenges. However, without a Senate supermajority vote to override the filibuster, new legislation fails. While the budget reconciliation process has provided one of the few pathways around the filibuster, that process is limited to budgetary outlays and revenue measures. Consequently, a “tax trench” has been worn from Congress repeatedly pushing major regulatory and public benefits legislation through the process as tax provisions. Now, the tax trench is set to …


Tax Regulations In A Loper Bright Light, Blaine G. Saito Oct 2025

Tax Regulations In A Loper Bright Light, Blaine G. Saito

Florida Tax Review

The Supreme Court’s decision in Loper Bright Enterprises. v. Raimondo overturned Chevron deference. In doing so, Loper Bright loosed chaos into many areas of administrative law, including tax. Indeed, the majority opinion in Loper Bright undid Chevron but left open the question of what the actual standard of review is, namely, whether it is de novo or Skidmore applies.

Tax too will suffer some of the chaos, especially as courts work out the matters. But both the positive citation in the opinion of Skidmore along with some of the language supporting long-standing regulations that are contemporaneously promulgated with the statute’s …


Have Your Cake And Eat It Too, Using Apportionment To Preserve Congress's Tax Power, Donald B. Tobin Oct 2025

Have Your Cake And Eat It Too, Using Apportionment To Preserve Congress's Tax Power, Donald B. Tobin

Florida Tax Review

The Constitution provides Congress with extremely broad taxing power, and the Supreme Court has recognized that this power is “virtually without limitation.” As budget deficits and income inequality in the United States increase, policymakers are examining options to tax wealth, either through a wealth tax or through taxes on untaxed capital gains. Opponents of these measures have turned to the apportionment requirement in the Constitution and argued that these taxes are not “income taxes” and instead are “direct taxes” that must be apportioned among the states. They further argue that since these taxes cannot be apportioned fairly, any wealth tax …


The Decline Of Chevron, The Rise Of Loper Bright And The Shifting Sands Of Tax Law, Doron Narotzki, Tamir Shanan Oct 2025

The Decline Of Chevron, The Rise Of Loper Bright And The Shifting Sands Of Tax Law, Doron Narotzki, Tamir Shanan

Florida Tax Review

The repeal of the Chevron deference doctrine has triggered what some may argue is a seismic shift in how tax law may be interpreted and applied, which may have far-reaching implications for taxpayers, the Internal Revenue Service and the federal government. This Article examines the evolving landscape of U.S. federal tax law in the wake of the Loper Bright decision, specifically focusing on the tax and economic consequences for key tax areas such as the General Anti-Abuse Rule and the complicated foreign tax credit and transfer pricing regimes, as well as the rules that characterize financial instruments or equity investments …


Moore Questions, Some Answers: Fixing The Personal Tax System Despite Constitutional Constraints, David Gamage, John R. Brooks, Edward J. Mccaffery Oct 2025

Moore Questions, Some Answers: Fixing The Personal Tax System Despite Constitutional Constraints, David Gamage, John R. Brooks, Edward J. Mccaffery

Florida Tax Review

Moore v. United States was expected to rule on the constitutional necessity of the tax-law realization requirement originating from Eisner v. Macomber, a potential impediment to progressive tax reform efforts aimed at shutting down the planning techniques of Buy Borrow Die. The various opinions in Moore, however, provided no definitive answer to this core question, instead leaving many more questions. Amid the lingering uncertainty, we argue that various responses to the problem of wealthy Americans’ not needing to pay any taxes remain possible after Moore. An incremental, “mix-and-match” approach to progressive tax reform may best suit …


Containing The Blast Radius: Can Congress Save The Code From Realization?, Reuven Avi-Yonah, Elise Hocking, Muskan Sharma Oct 2025

Containing The Blast Radius: Can Congress Save The Code From Realization?, Reuven Avi-Yonah, Elise Hocking, Muskan Sharma

Florida Tax Review

The Supreme Court’s decision in Moore v. United States avoided enshrining realization as a constitutional requirement for taxing income. But four Justices were in favor of doing so, and the majority opinion explicitly avoided deciding the issue. Thus, it is quite plausible to imagine that a future case would garner five votes in favor of constitutionalizing realization. This Article addresses the question whether Congress can do anything preemptively to contain the “blast radius” of such an explosive decision and limit the ensuing “fiscal calamity.”


Charles And Kathleen Moore And The Coming Tax Armageddon, Calvin H. Johnson Oct 2025

Charles And Kathleen Moore And The Coming Tax Armageddon, Calvin H. Johnson

Florida Tax Review

The Supreme Court decided last term, against predictions, that U.S. shareholders could be taxed on the undistributed earnings of their foreign corporation. The Court expressly did not decide the “Armageddon question,” whether a wealth tax or mark-to-market tax would be constitutional.

In the coming Armageddon, the Court needs to reverse the error in Pollock v. Farmers’ Loan & Trust Co., which said that the Constitution “prevent[s] an attack upon accumulated property by mere force of numbers.” That is exactly wrong. Apportionment of direct tax in fact was written to reach the wealth of the states using the labor of …


Foreword, David Hasen Oct 2025

Foreword, David Hasen

Florida Tax Review

In the 2023 Term, the Supreme Court decided three cases that are likely to have significant implications for the federal tax system. Moore v. United States presages a resuscitated constitutional realization requirement for the income tax—a requirement long thought moribund, if not dead, by most commentators and policymakers. Loper Bright Enterprises v. Raimondo jettisoned the Chevron doctrine’s deferential standard of review of agency rulemaking, returning the standard to some perhaps modified version of its more searching pre-Chevron status. And Corner Post, Inc. v. Board of Governors of the Federal Reserve System held that the statute of limitations for most …


A Model Research Synthesis Essay: Gender Justice In Contemporary Texts In Conversation With Arthur Miller's The Crucible, Jennifer Golobic Oct 2025

A Model Research Synthesis Essay: Gender Justice In Contemporary Texts In Conversation With Arthur Miller's The Crucible, Jennifer Golobic

Virginia English Journal

No abstract provided.


Asynchronous Reliable Transmission (Art) Protocol For Application-To-Application Communication, Preet Nepolean Dabre Mr., Ashish Kumar Khatri, Sinan Majeed Kadavath, Deepak Kumar Singh, Avinash Sai Pavan Munnangi Oct 2025

Asynchronous Reliable Transmission (Art) Protocol For Application-To-Application Communication, Preet Nepolean Dabre Mr., Ashish Kumar Khatri, Sinan Majeed Kadavath, Deepak Kumar Singh, Avinash Sai Pavan Munnangi

Defensive Publications Series

Present disclosure provides techniques for asynchronous reliable transmission (ART) protocol for Application-to-Application messages. A communication protocol is designed to support communication between two devices asynchronously over channels that have limitations to facilitate asynchronous communication and have limited bandwidth. The ART protocol solves communication challenges that arise when transmitting data over channels with such limitations. The ART protocol has the provision to expand for future use cases such as encryption. Further, the ART Protocol provides mechanisms for data packet fragmentation, allowing larger packets to be transmitted over channels with limited bandwidth.


Role Of Social Comparison Orientation On Financial Management Behavior In A Developing Nation: Examining The Mediating Role Of Financial Self-Efficacy And The Moderating Effect Of Financial Socialization, Afm Jalal Ahamed, Yam B. Limbu Oct 2025

Role Of Social Comparison Orientation On Financial Management Behavior In A Developing Nation: Examining The Mediating Role Of Financial Self-Efficacy And The Moderating Effect Of Financial Socialization, Afm Jalal Ahamed, Yam B. Limbu

Department of Marketing Faculty Scholarship and Creative Works

Purpose – This study aims to explore the impact of social comparison orientation (SCO) on financial management behavior (FMB) in a developing country with a collectivist culture. It examines how SCO is related to FMB directly and through financial self-efficacy (FSE) and how financial socialization (FS) moderates the SCO–FMB relationship. Design/methodology/approach – Data was collected from 301 adults in Dhaka, Bangladesh, using self-administered survey questionnaires. Mediation and moderation analyses were performed using Smart PLS software. Findings – The results indicate that SCO was positively associated with FMB. FSE mediates this relationship, enhancing SCO’s positive impact on FMB. Additionally, FS moderates …


Holy Cross Magazine, Vol. 59, No. 3, Fall 2025, College Of The Holy Cross Oct 2025

Holy Cross Magazine, Vol. 59, No. 3, Fall 2025, College Of The Holy Cross

Holy Cross Magazine

Frank Kartheiser ’72 is Comfortable With Your Discomfort
The community organizer and co-founder of the Mustard Seed soup kitchen and food pantry has been feeding the poor and clothing the hungry of Worcester for more than 50 years. His greatest dream is that it closes, yet the need continues to grow.
Story by Marybeth Reilly-McGreen ’89
Photography by Caroline Axvig

The Catholic Church’s Best Kept Secret
Rooted in Scripture and the Church's understanding of human dignity, Catholic Social Teaching helps people live out their faith in the world.
Story by Marybeth Reilly-McGreen ’89
Photography by Michael Ivins

Working to Get …


Chihean Jones V. Usa Oct 2025

Chihean Jones V. Usa

2025 Decisions

USDC for the Eastern District of Pennsylvania


Steering Minutes 10/09/2025, Steering Committee Oct 2025

Steering Minutes 10/09/2025, Steering Committee

Steering Committee

No abstract provided.


Indigent Defense: How The Attorney Shortage Crisis Raises The Continued Need For Public Defense In Rural Areas Of The Lone Star State, Cody Jess Huffman Oct 2025

Indigent Defense: How The Attorney Shortage Crisis Raises The Continued Need For Public Defense In Rural Areas Of The Lone Star State, Cody Jess Huffman

The Scholar: St. Mary's Law Review on Race and Social Justice

Abstract: The Sixth Amendment provides numerous rights, one of the most important being the right to counsel. The right to an attorney is crucial because it attaches at adversarial hearings such as interrogations, arraignments, and other serious matters as an individual weaves throughout the obstacles of the criminal justice system. An important distinction in that right to counsel as the admonishments are delivered is that not only does an individual have the right to counsel, often meaning one can be retained, but if an individual cannot afford to hire a private attorney, one will be appointed to them. As times …


Pawns In The Power Struggle: Navigating Creative Labor Precarity Across Mcns, Platforms, And State Regulation In China, Qingyue Sun Oct 2025

Pawns In The Power Struggle: Navigating Creative Labor Precarity Across Mcns, Platforms, And State Regulation In China, Qingyue Sun

Interdisciplinary Studies

This study examines how digital creators navigate the precarious Chinese digital creative industries (DCCIs), shaped by multi-channel networks (MCNs), platform logic, and intensifying state intervention. Drawing on interviews with 34 creators, I identified three challenges facing Chinese creators: (1) dual exploitation by volatile platforms and capricious MCN management; (2) erosion of creative autonomy under MCN gatekeeping and state oversight; (3) involuntarily being enlisted as propaganda artisans. Creators, especially those affiliated with MCNs, are increasingly positioned as state labor with governed creativity: cultural workers whose output is shaped, constrained, and redirected by the layered imperatives of state mandates, platform governance, and …


Using Serial Open Circuit Potentiometry To Study Ce And Gd Deposition In Molten Licl-Kcl Eutectic, Ranon G. Fuller, Guy L. Fredrickson, Devin Rappleye Oct 2025

Using Serial Open Circuit Potentiometry To Study Ce And Gd Deposition In Molten Licl-Kcl Eutectic, Ranon G. Fuller, Guy L. Fredrickson, Devin Rappleye

Faculty Publications

The ability to electrochemically separate individual species in a pyrochemical reprocessing salt relies on first being able to detect a separation in their reaction potentials. This requires the ability to measure reaction potentials with extreme precision. In this work, we introduce a novel technique called serial open circuit potentiometry (SOCP) and demonstrate its effectiveness at precisely measuring metal deposition reaction potentials. SOCP has several advantages over traditional open circuit potentiometry, including its abilities to quantify the error of measured equilibrium potentials by averaging many individual OCP measurements, determine overpotential deposition nucleation potentials to instrument precision, and simultaneously determine the nucleation …