Digital Commons Network^™

In Re: Erik Khan

2025 Decisions

USDC for the District of New Jersey

Targeting The Bcl2 Family: Advances And Challenges In Bh3 Mimetic-Based Therapies, Nabanita Mukherjee, James Sheetz, Yiqun Shellman

Student Papers, Posters & Projects

The BCL2 family of proteins plays a pivotal role in regulating apoptosis and cellular homeostasis, making them critical therapeutic targets in cancer and other diseases characterized by pathological cell survival. BH3 mimetics, small molecules that selectively inhibit anti-apoptotic BCL2 family members, have achieved significant clinical success, particularly in hematologic malignancies. However, several challenges remain, including resistance mechanisms, toxicity (such as MCL1 inhibitor-associated cardiotoxicity), and the intricate balance between apoptotic and non-apoptotic functions. This review provides a comprehensive overview of BCL2 family biology, the development and clinical application and outcomes of BH3 mimetics, and the emerging resistance mechanism known as double-bolt …

Board Of Directors Meeting Minutes (October 10, 2025), File 1, Dmacc

Board of Directors Meeting Minutes

This file contains the minutes from the Des Moines Area Community College Board meeting held on October 10, 2025.

Lewis V. Hibbert

All Decisions

The Appellate Term affirmed the Civil Court's dismissal of the tenant's complaint for breach of lease; breach of warranty of habitability; and retaliation. The court properly applied res judicata; finding these claims arose from the same transactions as those previously settled or litigated in a prior landlord and tenant proceeding; including an allegation of harassment that should have been raised in Housing Court. Additionally; the tenant's affirmation opposing the landlord's motion was inadmissible for failing to include the mandatory language required by CPLR 2106.

Rh 507-517 West 171 Street Llc V. Linck

All Decisions

In a nonpayment proceeding where the tenant interposed a rent overcharge defense, the court granted the tenant's motion for discovery. The court found the apartment's rent history unreliable due to missing registrations and a significant rent increase, warranting discovery beyond the statutory lookback period. The landlord's cross-motion for outstanding and pendente lite use and occupancy was denied without prejudice, as the tenant raised colorable defenses of rent overcharge and warranty of habitability under RPAPL § 745(2)(a)(iv)-(v).

Safely Exploring Novel Actions In Recommender Systems Via Deployment-Efficient Policy Learning, Haruka Kiyohara, Yusuke Narita, Yuta Saito, Kei Tateno, Takuma Udagawa

Cowles Foundation Discussion Papers

In many real recommender systems, novel items are added frequently over time. The importance of sufficiently presenting novel actions has widely been acknowledged for improving long-term user engagement. A recent work builds on Off-Policy Learning (OPL), which trains a policy from only logged data, however, the existing methods can be unsafe in the presence of novel actions. Our goal is to develop a framework to enforce exploration of novel actions with a guarantee for safety. To this end, we first develop Safe Off-Policy Policy Gradient (Safe OPG), which is a model-free safe OPL method based on a high confidence off-policy …

Navigating Night Shift: The Role Of A Clinical Resource Nurse, Jodie Gord, Ashley Burbey

Nursing

No abstract provided.

Predictors Of Lower-Limb Arterial Occlusion Pressure Across Commonly Used Cuff Widths, Isaac J. Wedig, Isaac M. Lennox, Erich J. Petushek, John J. Durocher, John Mcdaniel, Steven J. Elmer

Michigan Tech Publications

We compared predictors of lower-limb arterial occlusion pressure (AOP) across commonly used blood flow restriction (BFR) cuff widths (11, 13, 18 cm) and developed prediction equations to estimate AOP for each cuff. Participants (n = 116) underwent measurements of thigh circumference (TC), systolic (SBP) and diastolic (DBP) blood pressure, and AOP was assessed using Doppler ultrasound in a seated position. Multiple linear regression models with commonality analysis and mixed-effects models were used to identify and compare predictors of AOP between each cuff. LASSO regression with bootstrap resampling was used to develop and internally validate prediction equations. TC, SBP, DBP, age, …

Ligand-Receptor Interactions Induce And Mediate Regulatory Functions Of Batf3+ B Cells, Funan He, Weiwei Luo, Jingwei Wang, Maria J Fernandez, Uday P Pratap, Mustafa Khan, Karli Hinton, Sai Eashan Vankamamidi, Dariela Perez, Carlos E Rivera, Harshita B Gupta, Fushun Zhang, Zhenqing Ye, Yidong Chen, Xiao-Dong Li, Gangadhara R Sareddy, Hong Zan, Yue Li, Evelien M Bunnik, Guangming Zhong, Christopher A Hunter, Ross M Kedl, Zhinan Yin, Booki Min, Diako Ebrahimi, Siyuan Zheng, Tyler J Curiel, Yan Xiang, Ratna K Vadlamudi, Paolo Casali, Zhenming Xu

Faculty, Staff and Student Publications

B cells express many protein ligands, yet their regulatory functions are incompletely understood. We profiled ligand expression across murine B sublineage cells, including those activated by defined receptor signals, and assessed their regulatory capacities and specificities through in silico analysis of ligand-receptor interactions. Consequently, we identified a B cell subset that expressed cytokine interleukin-27 (IL-27) and chemokine CXCL10. Through the IL-27–IL-27 receptor interaction, these IL-27/CXCL10-producing B cells targeted CD40-activated B cells in vitro and, upon induction by immunization and viral infection, optimized antibody responses and antiviral immunity in vivo. Also present in breast cancer tumors and retained there through CXCL10-CXCR3 …

Representation, Dynamics And Optimization Of Physical Structures, Fan Feng

Dartmouth College Ph.D Dissertations

Computational tools play a vital role in structural analysis and design, enabling engineers and researchers to optimize performance, reduce material usage, and explore novel configurations across solids and fluids. Capturing, analyzing, and optimizing these structures while balancing efficiency, stability, and adaptability remains a central challenge. This thesis proposes three complementary methods that advance representation, simulation, and optimization. We present an impulse (gauge) fluid formulation that utilizes the impulse gauge variable to reduce numerical diffusion and better preserve coherent flow features such as vorticity at practical resolutions. We introduce a differentiable Voronoi representation for cellular solids that provides smooth implicit boundaries …

College For All And The Postsecondary Experiences Of Rural First-Generation College Students: Patterns Of Alignment With A Predominant Master Narrative, Andrew D. Coppens, Sarah Jusseaume, Jayson O. Seaman, Cindy L. Hartman, Erin H. Sharp

Faculty Publications

The aim of this study was to understand the experiences of rural, first-generation college (RFGC) students in relation to dominant culturally normative expectations about postsecondary educational and workforce trajectories. The study adopted patterns of engagement with a master narrative as both a conceptual framework and unit of analysis, examining both biography and cultural ecologies as well as highlighting agency in the lives and choices of study participants. Evidence is drawn from 4 in-depth narrative interviews with each of 14 RFGC students, conducted both at school and students’ homes, from rural and small-town communities. Results show that a master narrative of …

Lessons Learned: Katalin Mérő, Salil Gupta

Journal of Financial Crises

Between 1990 and 2010, Katalin Mérő served in various roles for Hungary’s central bank, Magyar Nemzeti Bank, and the Hungarian Financial Supervisory Authority. She led the Economics, Risk Assessment, and Regulatory Directorate between 2005 and 2019 and was the deputy head of the Financial Stability Department. She was also a member of the Joint Board of Appeal of European Supervisory Authority from 2011 to 2021. Mérő graduated from the Corvinus University of Budapest and received a PhD in 2005 from the Budapest University of Technology and Economics. Since 2016, she has served as an associate professor at Budapest Business School, …

Stressing The Stress Tests, Natasha Sarin, Til Schuermann

Journal of Financial Crises

In the spring of 2023, Silicon Valley Bank, Signature Bank, and First Republic Bank failed, owing to predictable rate hikes by the Federal Reserve. It’s clear from these recent events that the current US stress-testing system is ill-suited to mitigate risk associated with the banking system, especially when looking at smaller regional banks that aren’t subjugated to annual stress testing. Stress testing as a regulatory tool is also exposed to significant legal risks following recent Supreme Court jurisprudence that draws into question the viability of the status quo. Today, regulators and other interested parties must change tacks to craft a …

W&L Law Fall Scholarship Celebration 2025, Andrew Christensen, Michelle Cosby, Brandon Hasbrouck, Jennifer Mitchell, Melanie D. Wilson

Library Events

On October 9, 2025, the Washington and Lee Law Library hosted the fifth W&L Law Fall Scholarship Celebration. The event was co-sponsored by the Frances Lewis Law Center and took place in the Law Library's main reading room from 5:00 to 7:00 p.m.

On display were dozens of scholarly articles, books, chapters, and court briefs authored by the W&L Law faculty and student body between October 2022 and October 2025. Additional works were accessible online via QR codes to W&L Law Scholarly Commons institutional repository. A selection of vintage scholarship by former W&L Law professors was also on display, courtesy …

2017 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2016 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2014 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2012 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2009 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2007 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

2006 - Appalachian Student Research Forum Program Booklet, Appalachian Student Research Forum, East Tennessee State University

Appalachian Student Research Forum

No abstract provided.

The Tax Trench Deepens, Tracey M. Roberts

Florida Tax Review

Congress, long divided, has been in gridlock for decades. The result has been regulatory ossification. Existing statutes lack the flexibility to manage the country’s many technological, social, environmental, sectoral and market challenges. However, without a Senate supermajority vote to override the filibuster, new legislation fails. While the budget reconciliation process has provided one of the few pathways around the filibuster, that process is limited to budgetary outlays and revenue measures. Consequently, a “tax trench” has been worn from Congress repeatedly pushing major regulatory and public benefits legislation through the process as tax provisions. Now, the tax trench is set to …

Tax Regulations In A Loper Bright Light, Blaine G. Saito

Florida Tax Review

The Supreme Court’s decision in Loper Bright Enterprises. v. Raimondo overturned Chevron deference. In doing so, Loper Bright loosed chaos into many areas of administrative law, including tax. Indeed, the majority opinion in Loper Bright undid Chevron but left open the question of what the actual standard of review is, namely, whether it is de novo or Skidmore applies.

Tax too will suffer some of the chaos, especially as courts work out the matters. But both the positive citation in the opinion of Skidmore along with some of the language supporting long-standing regulations that are contemporaneously promulgated with the statute’s …

Have Your Cake And Eat It Too, Using Apportionment To Preserve Congress's Tax Power, Donald B. Tobin

Florida Tax Review

The Constitution provides Congress with extremely broad taxing power, and the Supreme Court has recognized that this power is “virtually without limitation.” As budget deficits and income inequality in the United States increase, policymakers are examining options to tax wealth, either through a wealth tax or through taxes on untaxed capital gains. Opponents of these measures have turned to the apportionment requirement in the Constitution and argued that these taxes are not “income taxes” and instead are “direct taxes” that must be apportioned among the states. They further argue that since these taxes cannot be apportioned fairly, any wealth tax …

The Decline Of Chevron, The Rise Of Loper Bright And The Shifting Sands Of Tax Law, Doron Narotzki, Tamir Shanan

Florida Tax Review

The repeal of the Chevron deference doctrine has triggered what some may argue is a seismic shift in how tax law may be interpreted and applied, which may have far-reaching implications for taxpayers, the Internal Revenue Service and the federal government. This Article examines the evolving landscape of U.S. federal tax law in the wake of the Loper Bright decision, specifically focusing on the tax and economic consequences for key tax areas such as the General Anti-Abuse Rule and the complicated foreign tax credit and transfer pricing regimes, as well as the rules that characterize financial instruments or equity investments …

Moore Questions, Some Answers: Fixing The Personal Tax System Despite Constitutional Constraints, David Gamage, John R. Brooks, Edward J. Mccaffery

Florida Tax Review

Moore v. United States was expected to rule on the constitutional necessity of the tax-law realization requirement originating from Eisner v. Macomber, a potential impediment to progressive tax reform efforts aimed at shutting down the planning techniques of Buy Borrow Die. The various opinions in Moore, however, provided no definitive answer to this core question, instead leaving many more questions. Amid the lingering uncertainty, we argue that various responses to the problem of wealthy Americans’ not needing to pay any taxes remain possible after Moore. An incremental, “mix-and-match” approach to progressive tax reform may best suit …

Containing The Blast Radius: Can Congress Save The Code From Realization?, Reuven Avi-Yonah, Elise Hocking, Muskan Sharma

Florida Tax Review

The Supreme Court’s decision in Moore v. United States avoided enshrining realization as a constitutional requirement for taxing income. But four Justices were in favor of doing so, and the majority opinion explicitly avoided deciding the issue. Thus, it is quite plausible to imagine that a future case would garner five votes in favor of constitutionalizing realization. This Article addresses the question whether Congress can do anything preemptively to contain the “blast radius” of such an explosive decision and limit the ensuing “fiscal calamity.”

Charles And Kathleen Moore And The Coming Tax Armageddon, Calvin H. Johnson

Florida Tax Review

The Supreme Court decided last term, against predictions, that U.S. shareholders could be taxed on the undistributed earnings of their foreign corporation. The Court expressly did not decide the “Armageddon question,” whether a wealth tax or mark-to-market tax would be constitutional.

In the coming Armageddon, the Court needs to reverse the error in Pollock v. Farmers’ Loan & Trust Co., which said that the Constitution “prevent[s] an attack upon accumulated property by mere force of numbers.” That is exactly wrong. Apportionment of direct tax in fact was written to reach the wealth of the states using the labor of …

Foreword, David Hasen

Florida Tax Review

In the 2023 Term, the Supreme Court decided three cases that are likely to have significant implications for the federal tax system. Moore v. United States presages a resuscitated constitutional realization requirement for the income tax—a requirement long thought moribund, if not dead, by most commentators and policymakers. Loper Bright Enterprises v. Raimondo jettisoned the Chevron doctrine’s deferential standard of review of agency rulemaking, returning the standard to some perhaps modified version of its more searching pre-Chevron status. And Corner Post, Inc. v. Board of Governors of the Federal Reserve System held that the statute of limitations for most …

A Model Research Synthesis Essay: Gender Justice In Contemporary Texts In Conversation With Arthur Miller's The Crucible, Jennifer Golobic

Virginia English Journal

No abstract provided.