Digital Commons Network^™

Human Bone Marrow-Mesenchymal Stem Cells Differentiation Into Brain-Like Endothelial Cells, Yomna Soliman, Güli̇n Baran, Nur Mustafaoğlu

Turkish Journal of Biology

Background/aim: Brain microvascular endothelial cells (BMECs), which constitute the blood–brain barrier (BBB), are essential for maintaining central nervous system homeostasis. Like BMECs, multipotent mesenchymal stem cells (MSCs) originate from the mesodermal lineage. Thus, MSCs may serve as a direct and efficient cellular source for BMEC-like differentiation. Notably, differentiation of human induced pluripotent stem cells (hiPSCs) into BMECs typically involves a 2-step protocol: inducing mesodermal commitment followed by endothelial specification. In contrast, direct differentiation from MSCs could bypass the initial mesodermal induction step, offering a streamlined alternative. This study tested a novel strategy for differentiating MSCs into brain-like endothelial cells (BLECs), …

A Capability Maturity Model For Artificial Intelligence Integration In Supply Chain Management, Lordt Becklines

Dissertations

Artificial Intelligence (AI) is transforming Supply Chain Management (SCM), yet many organizations struggle to assess their readiness for AI adoption and to understand how AI capabilities develop across maturity stages. This dissertation addresses this gap by developing a Capability Maturity Model (CMM) for AI integration in SCM, grounded in Organizational Information Processing Theory (OIPT), the Resource-Based View, and related capability frameworks. The model provides a structured approach for evaluating an organization's information-processing requirements, resource configurations, and alignment needed for effective AI-enabled supply chain operations.

Using a design science research approach, the AI-SCM CMM and its associated assessment instrument were derived …

Showpower: A New Paradigm For Community Engagement, Sean Green

Community Engagement

For decades, the dominant paradigm in community engagement, education, and social work has relied heavily on the concept of "empowerment" to address the systemic gaps hindering marginalized populations. However, the etymological and practical applications of empowerment have increasingly devolved into a paternalistic, deficit-based model, implying a directional transfer of authority from a privileged institution to a subjugated community. As recent scholarship confirms, historically marginalized groups—such as first-generation and low-income students—continue to face persistent structural barriers despite decades of these traditional institutional interventions (López et al., 2023). This white paper formally introduces a novel theoretical framework, lexicon, and operational mindset: Showpower. …

Non-Glycosylated, Legumain-Cleavable Isacs Drive Potent Anti-Tumor Immunotherapy Via A Bystander Effect, Anqi Zhang, Mohan Reddy Mullapudi, Lina Wu, Michele Yi, Mohammad Asikur Rahman, Aiman A. Yaseen, H Kayla Zhong, Tracy A. Brooks, L Nathan Tumey

Pharmacy Faculty Scholarship

Pancreatic ductal adenocarcinoma (PDAC) is the most lethal form of pancreatic cancer, with poor prognosis driven by late diagnosis, therapeutic resistance, and an immunosuppressive tumor microenvironment. Interactions between tumor cells and immune cells promote immune evasion and tumor progression, limiting the efficacy of immune checkpoint blockade and other immunotherapies. Given the high expression of trophoblast cell surface antigen 2 (TROP2) in PDAC, we developed a TROP2-targeted Toll-like receptor 7 (TLR7) agonist (E104) designed for selective accumulation within the tumor microenvironment to activate antitumor immunity. Although antibody bioactivity is traditionally linked to Fcγ receptor (FcγR) engagement and recruitment of effector cells, …

Structure–Activity Modeling And Hybrid Machine Learning-Based Prediction Of Bioactivity In Pyrazole Derivatives For Drug Discovery Applications, Kader Şahi̇n, Serhat Kiliçarslan, Serdar Durdaği, Emi̇n Saripinar

Turkish Journal of Biology

Background/aim: Pyrazole derivatives are of growing interest due to their diverse pharmacological activities. However, their biological activity is often highly sensitive to subtle structural modifications. Existing quantitative structure–activity relationships (QSAR) approaches frequently fail to capture the conformational flexibility and nonlinear structure–activity relationships (SAR) of such heterocyclic scaffolds, creating a gap in the accurate prediction of their biological profiles. Therefore, there is a strong need for more robust and predictive computational frameworks. This study addresses this gap by integrating four-dimensional (4D)-QSAR descriptors with hybrid machine learning (ML) techniques to improve predictive accuracy and provide a more reliable tool for structure-based drug …

February 23 Elections, Census & Redistricting Update, Jeffrey M. Wice

Elections, Census & Redistricting Updates

No abstract provided.

Role Of Piezo1 Channels Expressed In Pvn In Regulating Sympathetic Nerve Activity And Arterial Blood Pressure In Rats, Yue Chen, Wei Guo, Jichun Wang, Min Wang, Yuying Yang, Gregory Miodonski, Enshe Jiang, Qing Hui Chen, Yi Yang, Renjun Wang

Michigan Tech Publications

Mechanosensitive Piezo1 channels participate in regulating pain sensitivity, insulin secretion, and vascular tension; however, their expression in the autonomic paraventricular nucleus (PVN) and role in modulating sympathetic outflow and cardiovascular function remain unstudied. In this study, unilateral PVN microinjection of the Piezo1 channel blocker Dooku1 (0.1, 1, 10, 100, and 200 pmol) administered to anesthetized male rats increased renal sympathetic nerve activity (RSNA) and mean artery pressure (MAP) in a dose-dependent manner, with maximum increases of 93 ± 30% (p < 0.0001) and 21 ± 5 mmHg (p < 0.0001), respectively, elicited by Dooku1 at 100 pmol. Similarly, PVN microinjection of the peptide Piezo1 channel blocker GsMTx4 (1 nmol) significantly increased RSNA (p < 0.001) and MAP (p < 0.0001). Conversely, PVN-microinjected Piezo1 channel activators Yoda1 (5 nmol) and Jedi2 (5 nmol) did not significantly alter RSNA or MAP. Western blot and qRT-PCR analyses of the hypothalamic PVN showed abundant Piezo1 mRNA and protein expression. Immunofluorescence detection showed that Piezo1 was expressed in pre-sympathetic PVN neurons with axons projecting to the rostral ventrolateral medulla. We conclude that Piezo1 channels expressed in the autonomic PVN neurons play an important role in regulating sympathetic outflow and cardiovascular function.

Vol. 70, No. 7 (February 23, 2026)

Indiana Law Annotated

No abstract provided.

University Of New Hampshire 2025-2026 Faculty Senate Xxx - February 23, 2026 Minutes Summary, Faculty Senate

Faculty Senate Agendas & Minutes

No abstract provided.

Biological Evaluation Of Novel 6,9-Disubstituted Purine Analogues In High-Grade Serous Ovarian Cancer Cell Lines, Duygu Altiparmak, Deren Demi̇rel Yavuz, Pinar Kul Karadeni̇zli̇, İrem Durmaz Şahi̇n, Meral Tunçbi̇lek

Turkish Journal of Biology

Background/aim: High-grade serous ovarian cancer (HGSOC) remains one of the most aggressive forms of ovarian malignancy and frequently shows resistance to conventional therapies. This study aimed to synthesize a novel series of purine analogues, 6-[(4-substituted benzyl amine)/(4-substituted aniline)]-9-cyclopentyl purines, and evaluate their anticancer efficacy against HGSOC cell lines.

Materials and methods: We assessed the biological effects of the synthesized purine analogues on the OVCAR3, OVSAHO, and KURAMOCHI HGSOC cell lines using the sulforhodamine B assay. To investigate the mechanism of action, we conducted flow cytometry and western blot analyses, focusing on DNA replication and apoptosis.

Results: Among the tested compounds, …

Digital Competence Of Primary School Teachers In Andalusia (Spain): A Multidimensional Analysis Based On Self-Perceptions, Francisco Ábalos-Aguilera, Luis M. Romero-Rodríguez, Bárbara Mercedes Castillo Abdul Hadi

Artículos científicos

This study analyzes the self-perception of digital teaching competence (DTC) among primary education teachers in Andalusia, using an instrument based on the European DigCompEdu framework. Data were collected through a self-administered online questionnaire applied to a sample of 416 primary education teachers working in Andalusia. The study employed a mixed-methods design, combining quantitative analyses (descriptive, correlational, and comparative) with qualitative analysis of open-ended responses. Employing a mixed-methods approach, the research assesses teachers’ competence levels and examines differences according to professional experience, school ownership, teaching specialization, and territorial distribution. Results indicate that most teachers perceive themselves at intermediate levels of digital …

Immigrant Firms’ Commitment And Survival: Does Owner Identity Matter?, Nathaniel C. Lupton, Sarika Pruthi, Alfredo Jiménez

Faculty Research, Scholarly, and Creative Activity

How does immigrant ownership influence small firm survival in comparison with that of family ownership? While it is generally accepted that socioemotional wealth (SEW) preservation motivates family firms to avoid taking risks, this effect has not been considered in immigrant-owned firms. Many of the same affinity factors are likely to influence the survival of both ownership types, but we argue that immigrant-owned firms may experience them more strongly as they reside at the intersection of the liabilities of smallness and foreignness. Drawing on a large sample of small and medium enterprises (SMEs) in Ecuador, we find that immigrant-owned firms have …

Upper Extremity Return To Sport Functional Testing: A Systematic Review, Marisa Pontillo, Eric Bellm, Patrick Barber, Matthew L. Gauthier, Casey A. Unverzagt, George J. Davies

Physical Therapy Faculty Publications

Background: Upper extremity return to sport (RTS) assessments are not standardized with respect to which metrics to use, if the metrics are appropriate for all populations and levels of competition, and what constitutes good or poor test performance. Subsequently, clinicians may utilize suboptimal metrics to evaluate RTS readiness, or forgo objective criteria altogether. The purpose of this study was to examine the psychometric properties (reliability, agreement/measurement error, hypothesis testing/construct validity, criterion/predictive validity, responsiveness) of upper extremity functional tests used to assess RTS readiness.

Methods: This systematic review followed PRISMA guidelines, with all studies included assessed via the PEDro scale. Literature …

Intraspecific Meristic Variation In Gambusia Holbrooki From The Middle East And Its Implications For Stock Structure And Taxonomic Status, Fatema A. Al Fatle, Ana L. Ibaňez, Laith A. Jawad

Baghdad Science Journal

An analysis was conducted on the variation in the counts of seven meristic traits of the eastern mosquito fish, Gambusia holbrooki, using samples collected from ten different sites in the Middle East. These sites are located along the Tigris, Euphrates, and Shatt al-Arab Rivers, spanning across Iraq, Iran,Türkiye, and Syria. The study revealed a northward increase in the average values of these meristic traits, with the highest recorded in Türkiye and the lowest in the southern region of Iraq. The statistical analysis using Boxplots demonstrated that the seven meristic features were distinct across different rivers, with no overlap observed. …

Addressing Faculty Gaps In The Psychiatric Mental Health Nurse Practitioner Program, Shea Brock

Doctor of Nursing Practice Projects

Graduate nursing programs increasingly rely on adjunct faculty to sustain enrollment growth; however, inconsistent onboarding processes may contribute to variability in faculty preparedness and job satisfaction. The purpose of this quality improvement project was to implement a standardized adjunct faculty education program and evaluate its impact on adjunct faculty knowledge and job satisfaction within an online Psychiatric–Mental Health Nurse Practitioner (PMHNP) program. A quantitative, quasi-experimental one-group pre–post design was utilized. Six adjunct faculty members (n = 6) completed a 10-item EXXAT Knowledge Survey and a 10-item Faculty Satisfaction Survey before and after participation in a structured one-hour education session focused …

Synthesis, Characterization, And Anticancer Activity Study Of New Curcumin Analogues Against Mda-Mb 231 Breast Cancer Cell Line, Ola A. Odah, Rita S Elias, Shaker A. N. Al-Jadaan

Baghdad Science Journal

Synthesis of six new curcumin analogues was performed through condensation reaction of 3-methyl-2, 4-pentandione with substituted aromatic aldehyde derivatives and boron oxide in the presence of trimethylborate and butylamine. The reaction was carried out under ultrasonic irradiation. The synthesized compounds were identified using ¹H-, ¹³C-NMR, FT-IR spectroscopy, and electron impact mass spectrometry. The Swiss ADME website was used to predict the physicochemical properties of the new compounds using computational techniques like ADME studies. All produced compounds, according to this study, complies with the Lipinski rule of five. The microculture tetrazolium (MTT) assay was utilized to assess the investigated …

Section 12 As A Guide To Private Rights Of Action And § 1983 Claims Under The Voting Rights Act, Michael T. Morley

NULR Online

No abstract provided.

Mmu: 02/23/26-03/01/26, Student Bar Association

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The Contemporary Tax Journal Volume 14, No. 2 – Winter 2026

The Contemporary Tax Journal

No abstract provided.

The 41st Annual Tei – Sjsu High Tech Tax Institute Conference On November 3-4 ,2025: Domestic And Multistate Update, Shuang Zhang

The Contemporary Tax Journal

No abstract provided.

The 41st Annual Tei – Sjsu High Tech Tax Institute Conference On November 3-4, 2025: Tariffs, Transfer Pricing, §1059a, Customs, Retaliation And More, Mya Hoang

The Contemporary Tax Journal

No abstract provided.

Chimes: February 23, 2026, Calvin University

Chimes

A vibrant tapestry of cultures: Rangeela celebrates 30 years by Ava Roush & Ellerry Johnson

Puentes: Students building bridges amidst immigration concerns by Jorie Cho

Late Night Era's Concert: The end of an era by Ashley Hamons

Cave Night kickoff hosts local artists by Alec DeYoung

Composting streamlined and expanded to all underclassmen dorms by McKenna Wilkinson

Let's talk about sec: Calvin sexuality series confronts purity culture by Sarah Sparling

Scaling rock walls and studying Scripture by Ella Vanden Berg

Agent-To-Agent (A2a) Agent Card Creation Through Model Context Protocol (Mcp) And Agent Skill Compilation, Robert Barton, Arjun Sambamoorthy, Yathi Udupi

Defensive Publications Series

Proposed herein are techniques for a system that automatically generates Agent-to-Agent (A2A) capability cards by scanning Model Context Protocol (MCP) servers and semantically analyzing the tool inventories of the servers. The system transforms low-level tool specifications into high-level capability descriptions through a multi-stage pipeline that extracts schemas, infers dependencies, detects relationships, clusters related tools into skills, and abstracts skills into comprehensive capabilities. The output is a standardized A2A agent card that enables efficient agent discovery and collaboration in multi-agent systems.

Sekitar Pasal 115 Ketetapan Mpr-Ri No. I/Mpr/1978, Hermawan Ps. Notodipoero, S.H.

Jurnal Hukum & Pembangunan

Abstract

Perencanaan Pemukiman Transmigrasi Sebagai Usaha Pengembangan Wilayah Serta Masalah Hukum Dalam Penyediaan Dan Penyiapan Tanahnya, Arie Sukanti Sumantri, S.H.

Jurnal Hukum & Pembangunan

Abstract

Mahkamah Agung Cegah Berubahnya Tujuan Adopsi, Detty Tangkudung, S.H.

Jurnal Hukum & Pembangunan

Abstract

Nilai Dan Fungsi Keterangan Ahli (Dokter) Terhadap Suatu Tindak Pidana Di Depan Pengadilan, B.Z. Koemolontang, S.H.

Jurnal Hukum & Pembangunan

Abstract

Arbitrase Dagang Internasional Dari Negara-Negara Asia Afrika, Prof. Dr. Mr. Sudargo Gautama

Jurnal Hukum & Pembangunan

Abstract

The Impact Of Integrating Social Benefit Requirements For Urban Green Infrastructure And Place Identity Attributes To Enhance The Sense Of Place - Case Study Of Central Park, Madinaty, New Cairo City, Egypt, Ibrahim Magdi Mohammed, Rehab Abdelfatah Abdel Aziz Mahmoud

Mansoura Engineering Journal

This research develops an integrated model that links the social benefit requirements of Urban Green Infrastructure (UGI) with the non-physical attributes of Place Identity (PI) to enhance the Sense of Place (SOP) in contemporary urban environments. The need for this integration arises from limitations in current planning frameworks, which often prioritize ecological performance while overlooking cultural, perceptual, and behavioral dimensions that shape user attachment and belonging. The study adopts an inductive and synthesis-based approach to identify key UGI indicators across environmental, social, economic, and spatial dimensions, alongside PI attributes related to places’ legibility, uniqueness, publicness and territoriality, place’s identification. To …

Enhancing Thermal Energy Storage Efficiency Using Optimized Concrete Materials: A Review, Ahmed Mohamed Abbass, Ahmed M. El-Khayatt, Khaled A. Eltawil

Mansoura Engineering Journal

The increasing global energy demand and the environmental impact of fossil fuels necessitate the development of sustainable energy solutions. Solar energy is a promising alternative, but its intermittency and inefficiency limit its widespread adoption. This study explores the role of advanced concrete-based thermal energy storage systems in addressing these challenges. Key aspects examined include packing density optimization, high-temperature performance, and hydrothermal durability of concrete. The research highlights the importance of granulometric optimization, binder selection, and hydration mechanisms in enhancing concrete properties. Additionally, the effects of heat exposure on concrete durability, permeability, and mechanical strength are analyzed, with a focus on …