Digital Commons Network^™

Case Report: Gangrene After One Dose Of Investigational Stannic Pentetate Radiopharmaceutical, Zin W. Myint, Riham H. El Khouli, Bryan P. Lemieux, Charles A. Kunos

Radiology Faculty Publications

Introduction – Bone-seeking radiopharmaceuticals are the treatment of choice with clinical benefits for patients with extensive skeletal metastases, but they can also cause serious radiation-related adverse events (rrAEs). Management of rare and severe radiopharmaceutical rrAEs remains challenging because of incomplete knowledge of their natural history and pathogenetic mechanisms. We report a case of unlikely related gangrene following a protracted hospitalization after one dose of investigational [117mSn]tin-117m-diethylenetriaminepentaacetic acid (Sn-117m-DTPA) for treatment of extensive skeletal metastases from castration-resistant prostate cancer (mCRPC). Case presentation – An 80-year-old man with innumerable painful skeletal metastases from mCRPC developed anorexia and bilateral ankle edema with serous-draining …

The Quiet Revival Of The Effective Vindication Of Rights Doctrine, Myriam Gilles

Fordham Law Review

The U.S. Supreme Court’s 2013 decision in American Express v. Italian Colors Restaurantwas widely seen as the death knell for the “effective vindication of rights” doctrine—a judicially created rule that arbitration agreements are enforceable only “so long as the prospective litigant effectively may vindicate its statutory cause of action in the arbitral forum.” By upholding a class action–banning arbitration provision that rendered arbitration economically irrational, Italian Colors appeared to extinguish any meaningful limits on the enforcement of arbitration agreements.

But reports of the doctrine’s demise were premature. This Article uncovers how, in the decade since Italian Colors, lower …

Foreign Judgments In U.S. Courts, Yanbai Andrea Wang

Fordham Law Review

American law on foreign judgments is at an inflection point. For over a century, the doctrine has been shaped by concerns about outgoing U.S. judgments seeking asset collection in the civil law countries of continental Europe. But shifting trade flows and changing litigation tactics have carved a new landscape, demanding a return to foreign judgments law’s conceptual and doctrinal underpinnings. This Article first maps the new landscape, in which China is rapidly rising as a foremost foreign judgments interlocutor. Meanwhile, litigants are increasingly pursuing parallel litigation in multiple countries. The impact of incoming judgments and the interactions between related litigations …

Reorganizing The Administrative State: Executive Ambition And Legislative Constraint, Jordan Graber

Fordham Law Review

Beginning in the 1930s, Congress enacted a series of statutes granting presidents the authority to initiate reorganizations of the administrative state. Under these reorganization statutes, the president determined any necessary changes in agency organization and submitted a reorganization proposal to Congress, which could approve or reject the plan. Over the next fifty years, the president and Congress worked cooperatively to promote the effective and efficient functioning of the administrative state.

Despite the successful reorganization initiatives undertaken pursuant to these statutes, Congress has not conferred reorganization authority on any president in the last four decades. As a result, the organization of …

The Glomar Of It All: The Role Of External Disclosures In Agency Refusals To Confirm Or Deny Under Foia, Claire Paulanne Kurzweil

Fordham Law Review

The Freedom of Information Act (FOIA) requires federal agencies to disclose records upon request from the public, subject to statutory exemptions. Increasingly, agencies have relied on a nonstatutory mechanism, known as the Glomar response, to avoid disclosure. This mechanism, which allows agencies to refuse to confirm or deny the very existence of records, prevents courts and FOIA requesters from receiving even the basic information necessary for judicial review. As courts attempt to adapt FOIA’s review framework to the increased evidentiary constraints of Glomar responses, they are divided over whether to consider disclosures from outside the agency responding to the FOIA …

The Smallholder’S Dilemma In Agroecological Transitions: The Diseconomy Of Agroecology For Small Farmers In Industrial Agriculture, Qian Forrest Zhang

Research Collection School of Social Sciences

A scalar contradiction exists between agroecology's three goals: while ecological sustainability is best pursued at the landscape scale, social equity and livelihood goals often require organizing production at the small scale of family farms. In China's ‘industrial agriculture of small farmers’, ecological farming practices became economically unviable at small farmers' minuscule scales. Agroecological transitions almost always first go through a scale expansion, a process fraught with tension. The empirical analysis focuses on three ‘ecological farms’ that enjoyed favorable conditions unattainable to smallholders. Yet, lock-ins across five dimensions have either made their operations economically unsustainable or forced compromises in agroecological principles.

Targeting Breast Cancer Brain Metastasis Through Novel Combination Of Fda-Approved Orally Active Blood-Brain Barrier Permeable Ret And Tgli1 Inhibitors, Joshua Cha

Dissertations and Theses (Open Access)

Breast cancer is the most diagnosed cancer in American women, and breast cancer brain metastasis (BCBM) exhibits the worst prognoses with a life-expectancy averaging at 6 months. This short life expectancy is largely attributed to the lack of effective treatment. Many challenges remain unsolved, including the limited number of actionable targets for targeted therapy and effective blood-brain barrier (BBB) permeable drugs that are safe without promoting drug resistance. Therefore, there is an urgent call for identification of novel therapeutic targets and development of BBB-permeable drugs. One of the potential targets identified by our lab for BCBM targeted therapy is the …

From Antigen Presentation To Tumor Control: Mechanisms Of Type I Conventional Dendritic Cell-Based Cancer Vaccines, Josue E. Pineda

Dissertations and Theses (Open Access)

Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with in vitro-derived murine cDC1s elicits durable tumor control in multiple preclinical models; however, the immunological mechanisms underlying the efficacy of cDC1 vaccination remain unclear. Here, we examined whether in vitro-derived cDC1s resemble tumor-infiltrating DC populations and whether MHC-I and MHC-II antigen presentation contribute to cDC1-mediated tumor control following vaccination in melanoma.

As expected, MHC-I- or MHC-II-deficiency had minimal impact on …

Platelet Gαz Regulates Ovarian Tumor Growth And Mediates The Effects Of Chronic Stress, María G. Torres Carrizalez

Dissertations and Theses (Open Access)

Ovarian cancer is the most aggressive gynecologic cancer, with 12,450 estimated deaths in 2026. Elevated platelet counts are commonly observed in patients with ovarian cancer and are associated with enhanced tumor growth and poor prognosis. Patients with ovarian cancer are frequently exposed to elevated levels of stress, which has been correlated with accelerated disease progression and increased mortality. Interestingly, the platelet Gαz protein is activated by epinephrine through the α2A-adrenergic receptor, suggesting a potential mechanistic link between stress signaling and platelet-driven tumor progression. To investigate this, I evaluated the role of platelet Gαz in ovarian cancer using control (Gz^{fl/fl …}

Financial Technology And Household Wealth, Rongbo Zhou

Dissertations and Theses Collection (Open Access)

With the spread of mobile payment platforms in China, the micro-foundations of household financial behaviour have been reshaped, and this change is increasingly reflected in household property income. Based on microdata from the China Household Finance Survey (CHFS) for 2015, 2017, 2019, and 2021, this dissertation examines how mobile payment use affects household property income, through which channels this effect is transmitted, and how its impact differs across household groups, regional conditions, and macro-financial environments.

The empirical results show a positive association between the use of mobile payment platforms and household property income. This conclusion remains robust after controlling for …

Abnormal Trafficking And Processing Of Multiple Matrix Metalloproteinases Drive Cartilage Defects In Congenital Disorders Of Glycosylation, Chia-Lun Wu

All Dissertations

Congenital Disorders of Glycosylation (CDG) are rare metabolic diseases caused by defects in glycosylation. Despite identification of over 200 CDG types, the mechanisms linking glycosylation defects to diverse clinical phenotypes remain unclear. This dissertation uses zebrafish models of PMM2-CDG and STT3-CDG to redefine CDG pathogenesis, shifting from a simple glycan deficiency model to one involving disrupted cellular spatial organization.

We identify a protease-dependent pathway underlying craniofacial cartilage defects. Specifically, defective proteolytic processing of N-cadherin, a key adhesion molecule in chondrogenesis, is a central driver of pathology. We further uncover an unconventional trafficking mechanism in which ER stress and altered secretory …

"Because You Speak Two Languages": Latino Immigrant Families Negotiating Language Ideology, Liminality, And Education In Arkansas, Cindy Rauth

Graduate Theses and Dissertations

This dissertation presents a critical ethnographic study of lower socio-economic status, multilingual Latino immigrant families in one region of Arkansas, which has undergone rapid demographic changes in the last four decades. As the Latino population has grown, schools have struggled to accommodate the needs of their diverse students and families, which has contributed to below-grade-level literacy skills and significant student disengagement. This study examines students’ schooling experiences from the perspective of the family. Through an interdisciplinary approach, this study explores three interconnected themes: family experiences of schooling, language ideology, and liminality. A comprehensive examination of family educational experiences includes the …

El Leñador, May 2026, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

Cultivating Digital Belonging: A Phenomenological Study Of Black Male Students’ Experiences In A Title Three Online Student Support Hub, June Paulette Rogers

Education Doctorate Dissertations

This qualitative phenomenological study examined how Black male students at a public community college experienced digital belonging through a Title Three–funded Online Student Support Hub. Instead of focusing on broad institutional outcomes, the study centered on students' personal experiences. It investigated how students felt seen by staff, how relevant cultural references were integrated, and how quickly and thoughtfully the institution responded. Data came from nine participants through semi-structured interviews, reflective journals, and review of key documents. Through analysis, the study identified four key themes: building personal relationships, obstacles and feelings of separation, efforts to make digital support more personal, and …

From Synapse To Circuit: Mechanisms Of Behavioral Flexibility And Its Restoration After Prenatal Alcohol Exposure, Jayapriya Chandrasekaran

Biomedical Sciences ETDs

Behavioral flexibility—the ability to adapt behavior when contingencies change—is a fundamental executive function supported by orbitofrontal–striatal circuitry. This dissertation examined molecular, motivational, and circuit mechanisms underlying flexibility and its restoration after prenatal alcohol exposure (PAE). In healthy mice, GluN2B-containing NMDA receptors in the orbitofrontal cortex increased during outcome updating, while AMPA receptor subunits in the dorsal striatum rose during new learning, defining temporally distinct plasticity processes. PAE impaired reversal learning under low-reward conditions, but not when motivation was high, indicating altered thresholds for circuit engagement rather than permanent loss. Finally, optogenetic stimulation of OFC→dorsal striatum projections rescued flexibility in PAE …

The Eviction Caste System, Allison Freedman

Faculty Scholarship

The United States is facing a dire housing crisis, and most Americans agree that housing is a universal necessity. Yet under current Supreme Court jurisprudence, housing is not a fundamental right, and individuals facing housing insecurity from an eviction are generally not members of a suspect class. This is because eviction is often viewed as an individual problem and a symptom of poverty, which the Supreme Court has repeatedly affirmed is not a suspect classification. This Article disrupts the superficial narrative that eviction is an individualistic symptom of poverty, and instead views evictions from a systemic and historical perspective. It …

How Academic Pressure Is Declining The Mental Health Of South Korean Students, Lilyanne Boyland

East Asian Studies

South Korea’s education system is widely recognized for its academic excellence; however, this may highly impact students’ mental health and overall well-being, which can hinder their academic performance. Students are known to dedicate long hours of their day to their education, in addition to their daily academic schedules. This study focuses on how academic pressure, that is mostly driven by parents and educators, as well as traditional cultural values on education, affects the mental health of South Korean students. This thesis is divided into three sections: Historical and Cultural Contexts, South Korea’s Current Educational Environment, and Next Steps for South …

Youth In Leadership Positions: A Mediation Program Proposal, Abigail Horn

Sociology

Encountering the justice system can have harmful impacts on a child’s well-being and can lead to negative outcomes in the future, such as missing school and reoffending. This paper proposes a program to combat these impacts by creating infrastructure for schools to handle low level offenses within schools through a mentoring program. After a review of the literature on the current justice system in the United States, rehabilitative and restorative justice practices, and the effects of youth leadership positions, the “Re-Mentoring Program” is proposed. A play on the words "restorative" and "rehabilitative," this program involves youth who have offended, victims, …

Rethinking The Scope Of State Power: Territorial Jurisdiction, Popular Sovereignty, And Extraterritorial Legislation, Jeffrey Schmitt

William & Mary Law Review

The Supreme Court applies the territorial framework of international law to resolve disputes over the reach of state power. Under this framework, a state’s power is coterminous with its borders, such that a state’s regulatory power within its territory is limited only by federal law. The Court recently used this framework to overrule an obscure line of Dormant Commerce Clause cases that held that a state regulation of local conduct could have impermissible extraterritorial effects.

This Article argues that the territorial model of state power from international law does not account for the division of sovereignty within our federal system. …

Unrestricted: Why Access To A Special Victims' Counsel Should Not Rest On Victim Credibility, Kate Franco

William & Mary Law Review

Part I discusses the role of courts-martial in the military and the distinction between civilian ideals of justice and the military’s objective of “good order and discipline.” It also describes how the sociopolitical landscape in the early twenty-first century shaped the Uniformed Military Code of Justice (UCMJ), the internal decision to introduce counsel specifically for sexual assault victims, and Congress’s decision to require SVC [Special Victims' Counsel] programs across all branches. Part II examines the state of SVC programs today within branches and across the political landscape. It also provides a more detailed analysis of United States v. Deremer and …

Too Cruel For School: How Parental Rights Doctrine Can Help Protect Against Book Bans, Tessa K. Wild

William & Mary Law Review

This Note argues that parents’ rights protections are crucial to protecting against broad censorship in public schools, and that if states want to effectively regulate book removals, they should preemptively adopt laws similar to Minnesota’s section 134.51.

[...]

Part I of this Note will provide background information about book removals as a freedom of speech issue, as well as a history of how parents’ rights rhetoric is tied to book-removal issues. Part II will address both the history and legal standards of parents’ rights protections. Finally, Part III, using Minnesota and Utah as case studies, will apply parents’ rights law …

Growing Older Across Time And Space: The Impact Of Various Forms Of Capital On Social Support Networks Among Older Vietnamese Migrants, Hien Thi Nguyen, Lukasz Krzyzowski, Loretta Baldassar

Research outputs 2022 to 2026

Much has been written about the important role of social support networks (SSNs) for the well-being of older adults, encompassing their social, emotional and practical needs. Less is known about what happens to the SSNs of older people when they migrate, and even fewer studies have examined the impact of different forms of capital on these networks. Drawing on ethnographic interviews and participant observation with 22 older Vietnamese migrants in Australia (2020–21), this paper explores the influence of different forms of social, cultural, economic and symbolic capital on their SSNs. Data analysis comprised egocentric social network analysis of the connections …

Parenthood And Mental Health Among University Populations In Sub-Saharan Africa: A Cross-Sectional Study, Tuwani A. Rasengane, Ngozika Esther Ezinne, Antor Ndep, Nnamdi John Eseme, Susarah Maria Richter, Kingsley E. Agho, Ebele Gertrude Ejidike, Michael Agyemang Kwarteng, Kelechukwu Enyinnaya Ahaiwe, Nnaemeka Meribe, Obed Adonteng-Kissi, Edith Daniel-Nwosu, Mchillary Ogiemudia Osamudiamen, Ike Onyebuchi Oforbuike, Grace Obumneke Ogbonna, Isaura Ilorena D.Alva Brito Dos Santos, Okechi Ulumma Amaechi, Ugochukwu E. Uzuegbu, Khathutshelo Percy Mashige, Uchechukwu Levi Osuagwu

Research outputs 2022 to 2026

Background and Aims: This study examined the association between parenthood status and psychological well-being among university staff and students in sub-Saharan Africa (SSA). Methods: A cross-sectional, web-based survey was conducted across 22 universities in four SSA countries using convenience sampling. A total of 1189 university staff and students, including parents and non-parents, participated. Mental health outcomes were assessed using the Depression, Anxiety, and Stress Scales (DASS-21). Multinomial logistic regression models were used to examine associations between parenthood status and mental health outcomes after adjusting for sociodemographic and contextual factors. Results: Participants with children had lower odds of moderate depression (adjusted …

Red Teaming: Evaluating And Revising Attack Ideas Using Ai Prompts, Alexis D'Amato, Emma Theobald, Jack Rygg, Samuel Hunter, Joel Elson, Meg Shercliffe

Reports, Projects, and Research

In a red teaming exercise where participants used AI to evaluate and revise attack ideas against an adversarial group, results reveal that prompts involve multiple phases of the creative problem-solving process. During the exercise, participants were given a threat scenario and time with an unconstrained AI tool to evaluate an idea and generate a revised one. Input messages from the AI tool were collected and analyzed. In doing so, participants used AI prompts related to three core phases of the creative problem-solving process: information gathering, idea generation, and idea evaluation. This reveals that AI is used for various purposes, above …

A New Approach To Generate Combinatorial Patterns In Logical Analysis Of Data And Its Application To Predict College Retention, Salihah Ahmed E. Jaafari

Theses and Dissertations

Student retention and degree completion remain central challenges for higher-education institutions, with significant implications for student success, institutional effectiveness, and public accountability. While advances in predictive analytics have enabled earlier identification of students at risk of withdrawal, many commonly used machine learning approaches suffer from limited interpretability, constraining their practical usefulness for advising, intervention, and policy decision making. This dissertation addresses the problem of predicting student persistence by developing and evaluating optimization based, interpretable classification models within the Logical Analysis of Data (LAD) framework. Building on existing LAD formulations, this research introduces two novel pattern generation models, the Best Term …

Defining Civil Rico's "Injury To Business Or Property" Requirement: The Supreme Court Takes A Few Steps, Says It Punts, But Actually Fumbles, Randy D. Gordon

Faculty Scholarship

Throughout its history, the RICO statute has presented lawyers with something of an interpretive parlor game. It is indefinite along multiple dimensions and thereby given multiple interpretations, even down to the word level. In Medical Marijuana v. Horn, the Supreme Court set out to define one of RICO's civil-standing provisions: Namely, whether the statute's "injury to business or property" requirement can be satisfied when a plaintiff suffers both economic and personal injuries. In a 5-4 decision, members of the Court engaged in an interpretive battle over the meaning of the phrase and succeeded only in holding that civil RICO does …

Court-Stripping, Court-Packing, And Court Defying: Revisiting The Supreme Court’S Essential Functions, Curtis A. Bradley, Neil S. Siegel

Faculty Scholarship

The "essential functions thesis" is one of the most famous structural arguments in the field of federal courts. The thesis, which has been endorsed by a number of prominent scholars and the executive branch, posits that there are implicit, structural limits on Congress's authority to "strip" the Supreme Court of its appellate jurisdiction. Court-stripping, the thesis contends, is not allowed if it would undermine the essential functions of the Court-in particular, maintaining the supremacy and uniformity of federal law. In this Article, we revisit that thesis with three goals in mind. First, we aim to show that the structural arguments …

How Ai Destroys Institutions, Woodrow Hartzog, Jessica Silbey

Faculty Scholarship

Civic institutions—the rule of law, universities, and a free press—are the backbone of democratic life. They are the mechanisms through which complex societies encourage cooperation and stability, while also adapting to changing circumstances. The real superpower of institutions is their ability to evolve and adapt within a hierarchy of authority and a framework for roles and rules, while maintaining legitimacy for the knowledge produced and the actions taken. Purpose-driven institutions built around transparency, cooperation, and accountability empower individuals to take intellectual risks and challenge the status quo. This happens through the machinations of interpersonal relationships within those institutions, which broaden …

Revocation Reconsidered: Probation Advocacy Through A Litigation Lens, Shira M. Diner

Faculty Scholarship

Being found in violation of probation has dire consequences. The person found in violation can be imprisoned, upending them from their job, family, and community. Unlike incarceration after a criminal trial, a sentence after a violation of probation is not the result of a legal process characterized by robust due process protections. It is also often not the result of a forceful and thorough defense. It is instead the consequence of a hearing where lawyers with the fixed mindset of an inevitable finding of a violation don’t engage in the same preparation that they would if it was a trial. …

Antidiscrimination, Not Anti-Dei: The Real Story Of The Supreme Court's Recent Title Vii Precedent, Madeline H. Meth

Faculty Scholarship

For several years, my colleague and I had been litigating employment discrimination cases with facts that shocked our friends and family. For example, we fought Dallas County over a women-work-the-weekend policy that required women detention officers to work weekends while male colleagues took the weekends off. Likewise, we challenged the City of Cleveland when it moved our client, an emergency medical services supervisor, from the day shift to the night shift explicitly because he is Black. Then, in April 2024, in one of our client’s cases, Muldrow v. City of St. Louis, the U.S. Supreme Court unanimously overruled the …