Digital Commons Network^™

Platelet Gαz Regulates Ovarian Tumor Growth And Mediates The Effects Of Chronic Stress, María G. Torres Carrizalez

Dissertations and Theses (Open Access)

Ovarian cancer is the most aggressive gynecologic cancer, with 12,450 estimated deaths in 2026. Elevated platelet counts are commonly observed in patients with ovarian cancer and are associated with enhanced tumor growth and poor prognosis. Patients with ovarian cancer are frequently exposed to elevated levels of stress, which has been correlated with accelerated disease progression and increased mortality. Interestingly, the platelet Gαz protein is activated by epinephrine through the α2A-adrenergic receptor, suggesting a potential mechanistic link between stress signaling and platelet-driven tumor progression. To investigate this, I evaluated the role of platelet Gαz in ovarian cancer using control (Gz^{fl/fl …}

Financial Technology And Household Wealth, Rongbo Zhou

Dissertations and Theses Collection (Open Access)

With the spread of mobile payment platforms in China, the micro-foundations of household financial behaviour have been reshaped, and this change is increasingly reflected in household property income. Based on microdata from the China Household Finance Survey (CHFS) for 2015, 2017, 2019, and 2021, this dissertation examines how mobile payment use affects household property income, through which channels this effect is transmitted, and how its impact differs across household groups, regional conditions, and macro-financial environments.

The empirical results show a positive association between the use of mobile payment platforms and household property income. This conclusion remains robust after controlling for …

Abnormal Trafficking And Processing Of Multiple Matrix Metalloproteinases Drive Cartilage Defects In Congenital Disorders Of Glycosylation, Chia-Lun Wu

All Dissertations

Congenital Disorders of Glycosylation (CDG) are rare metabolic diseases caused by defects in glycosylation. Despite identification of over 200 CDG types, the mechanisms linking glycosylation defects to diverse clinical phenotypes remain unclear. This dissertation uses zebrafish models of PMM2-CDG and STT3-CDG to redefine CDG pathogenesis, shifting from a simple glycan deficiency model to one involving disrupted cellular spatial organization.

We identify a protease-dependent pathway underlying craniofacial cartilage defects. Specifically, defective proteolytic processing of N-cadherin, a key adhesion molecule in chondrogenesis, is a central driver of pathology. We further uncover an unconventional trafficking mechanism in which ER stress and altered secretory …

"Because You Speak Two Languages": Latino Immigrant Families Negotiating Language Ideology, Liminality, And Education In Arkansas, Cindy Rauth

Graduate Theses and Dissertations

This dissertation presents a critical ethnographic study of lower socio-economic status, multilingual Latino immigrant families in one region of Arkansas, which has undergone rapid demographic changes in the last four decades. As the Latino population has grown, schools have struggled to accommodate the needs of their diverse students and families, which has contributed to below-grade-level literacy skills and significant student disengagement. This study examines students’ schooling experiences from the perspective of the family. Through an interdisciplinary approach, this study explores three interconnected themes: family experiences of schooling, language ideology, and liminality. A comprehensive examination of family educational experiences includes the …

El Leñador, May 2026, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

Cultivating Digital Belonging: A Phenomenological Study Of Black Male Students’ Experiences In A Title Three Online Student Support Hub, June Paulette Rogers

Education Doctorate Dissertations

This qualitative phenomenological study examined how Black male students at a public community college experienced digital belonging through a Title Three–funded Online Student Support Hub. Instead of focusing on broad institutional outcomes, the study centered on students' personal experiences. It investigated how students felt seen by staff, how relevant cultural references were integrated, and how quickly and thoughtfully the institution responded. Data came from nine participants through semi-structured interviews, reflective journals, and review of key documents. Through analysis, the study identified four key themes: building personal relationships, obstacles and feelings of separation, efforts to make digital support more personal, and …

From Synapse To Circuit: Mechanisms Of Behavioral Flexibility And Its Restoration After Prenatal Alcohol Exposure, Jayapriya Chandrasekaran

Biomedical Sciences ETDs

Behavioral flexibility—the ability to adapt behavior when contingencies change—is a fundamental executive function supported by orbitofrontal–striatal circuitry. This dissertation examined molecular, motivational, and circuit mechanisms underlying flexibility and its restoration after prenatal alcohol exposure (PAE). In healthy mice, GluN2B-containing NMDA receptors in the orbitofrontal cortex increased during outcome updating, while AMPA receptor subunits in the dorsal striatum rose during new learning, defining temporally distinct plasticity processes. PAE impaired reversal learning under low-reward conditions, but not when motivation was high, indicating altered thresholds for circuit engagement rather than permanent loss. Finally, optogenetic stimulation of OFC→dorsal striatum projections rescued flexibility in PAE …

The Eviction Caste System, Allison Freedman

Faculty Scholarship

The United States is facing a dire housing crisis, and most Americans agree that housing is a universal necessity. Yet under current Supreme Court jurisprudence, housing is not a fundamental right, and individuals facing housing insecurity from an eviction are generally not members of a suspect class. This is because eviction is often viewed as an individual problem and a symptom of poverty, which the Supreme Court has repeatedly affirmed is not a suspect classification. This Article disrupts the superficial narrative that eviction is an individualistic symptom of poverty, and instead views evictions from a systemic and historical perspective. It …

How Academic Pressure Is Declining The Mental Health Of South Korean Students, Lilyanne Boyland

East Asian Studies

South Korea’s education system is widely recognized for its academic excellence; however, this may highly impact students’ mental health and overall well-being, which can hinder their academic performance. Students are known to dedicate long hours of their day to their education, in addition to their daily academic schedules. This study focuses on how academic pressure, that is mostly driven by parents and educators, as well as traditional cultural values on education, affects the mental health of South Korean students. This thesis is divided into three sections: Historical and Cultural Contexts, South Korea’s Current Educational Environment, and Next Steps for South …

Youth In Leadership Positions: A Mediation Program Proposal, Abigail Horn

Sociology

Encountering the justice system can have harmful impacts on a child’s well-being and can lead to negative outcomes in the future, such as missing school and reoffending. This paper proposes a program to combat these impacts by creating infrastructure for schools to handle low level offenses within schools through a mentoring program. After a review of the literature on the current justice system in the United States, rehabilitative and restorative justice practices, and the effects of youth leadership positions, the “Re-Mentoring Program” is proposed. A play on the words "restorative" and "rehabilitative," this program involves youth who have offended, victims, …

Rethinking The Scope Of State Power: Territorial Jurisdiction, Popular Sovereignty, And Extraterritorial Legislation, Jeffrey Schmitt

William & Mary Law Review

The Supreme Court applies the territorial framework of international law to resolve disputes over the reach of state power. Under this framework, a state’s power is coterminous with its borders, such that a state’s regulatory power within its territory is limited only by federal law. The Court recently used this framework to overrule an obscure line of Dormant Commerce Clause cases that held that a state regulation of local conduct could have impermissible extraterritorial effects.

This Article argues that the territorial model of state power from international law does not account for the division of sovereignty within our federal system. …

Unrestricted: Why Access To A Special Victims' Counsel Should Not Rest On Victim Credibility, Kate Franco

William & Mary Law Review

Part I discusses the role of courts-martial in the military and the distinction between civilian ideals of justice and the military’s objective of “good order and discipline.” It also describes how the sociopolitical landscape in the early twenty-first century shaped the Uniformed Military Code of Justice (UCMJ), the internal decision to introduce counsel specifically for sexual assault victims, and Congress’s decision to require SVC [Special Victims' Counsel] programs across all branches. Part II examines the state of SVC programs today within branches and across the political landscape. It also provides a more detailed analysis of United States v. Deremer and …

Too Cruel For School: How Parental Rights Doctrine Can Help Protect Against Book Bans, Tessa K. Wild

William & Mary Law Review

This Note argues that parents’ rights protections are crucial to protecting against broad censorship in public schools, and that if states want to effectively regulate book removals, they should preemptively adopt laws similar to Minnesota’s section 134.51.

[...]

Part I of this Note will provide background information about book removals as a freedom of speech issue, as well as a history of how parents’ rights rhetoric is tied to book-removal issues. Part II will address both the history and legal standards of parents’ rights protections. Finally, Part III, using Minnesota and Utah as case studies, will apply parents’ rights law …

Growing Older Across Time And Space: The Impact Of Various Forms Of Capital On Social Support Networks Among Older Vietnamese Migrants, Hien Thi Nguyen, Lukasz Krzyzowski, Loretta Baldassar

Research outputs 2022 to 2026

Much has been written about the important role of social support networks (SSNs) for the well-being of older adults, encompassing their social, emotional and practical needs. Less is known about what happens to the SSNs of older people when they migrate, and even fewer studies have examined the impact of different forms of capital on these networks. Drawing on ethnographic interviews and participant observation with 22 older Vietnamese migrants in Australia (2020–21), this paper explores the influence of different forms of social, cultural, economic and symbolic capital on their SSNs. Data analysis comprised egocentric social network analysis of the connections …

Parenthood And Mental Health Among University Populations In Sub-Saharan Africa: A Cross-Sectional Study, Tuwani A. Rasengane, Ngozika Esther Ezinne, Antor Ndep, Nnamdi John Eseme, Susarah Maria Richter, Kingsley E. Agho, Ebele Gertrude Ejidike, Michael Agyemang Kwarteng, Kelechukwu Enyinnaya Ahaiwe, Nnaemeka Meribe, Obed Adonteng-Kissi, Edith Daniel-Nwosu, Mchillary Ogiemudia Osamudiamen, Ike Onyebuchi Oforbuike, Grace Obumneke Ogbonna, Isaura Ilorena D.Alva Brito Dos Santos, Okechi Ulumma Amaechi, Ugochukwu E. Uzuegbu, Khathutshelo Percy Mashige, Uchechukwu Levi Osuagwu

Research outputs 2022 to 2026

Background and Aims: This study examined the association between parenthood status and psychological well-being among university staff and students in sub-Saharan Africa (SSA). Methods: A cross-sectional, web-based survey was conducted across 22 universities in four SSA countries using convenience sampling. A total of 1189 university staff and students, including parents and non-parents, participated. Mental health outcomes were assessed using the Depression, Anxiety, and Stress Scales (DASS-21). Multinomial logistic regression models were used to examine associations between parenthood status and mental health outcomes after adjusting for sociodemographic and contextual factors. Results: Participants with children had lower odds of moderate depression (adjusted …

Comprehensive Analytical Approaches To Biophysical And Hard Matter Systems, Carlos Munoz

Theses and Dissertations

In this work we define the methods and experimental techniques that are used in the synthesis, characterization, and development of biophysical and hard matter systems. These efforts encompass six principal areas: Comprehensive characterization of pathogenic bacteria, development of novel chemical methods for probing binding affinities in cellular systems, understanding the electronic properties of silicon/silicon dioxide interfaces, characterization of catalytic perovskite oxide materials, and lastly, heteroepitaxial growth of vanadium nitride thin films on the silicon nitride surface.The Lyme disease spirochete Borrelia burgdorferi (B. burgdorferi) causes an infection with diverse clinical outcomes, which can include arthritis as well as cardiac and neurological …

Reflections On The Use And Misuse Of Economic Analysis In Copyright, Glynn Lunney

Faculty Scholarship

Economic analysis has long been used to justify copyright regulation. Long before the Statute of Anne, the Stationer’s Guild told the story of the copying competitor, who in the absence of regulation, would copy every original book and offer it for less. In the story, the coping competitor would, in the absence of regulation, deprive the original author of an opportunity to recoup their authorship investment, and so lead to a world where no books at all would be published. To ensure sufficient incentives for authorship, some degree of copyright regulation was thought essential. At the same time, in the …

Red Teaming: Evaluating And Revising Attack Ideas Using Ai Prompts, Alexis D'Amato, Emma Theobald, Jack Rygg, Samuel Hunter, Joel Elson, Meg Shercliffe

Reports, Projects, and Research

In a red teaming exercise where participants used AI to evaluate and revise attack ideas against an adversarial group, results reveal that prompts involve multiple phases of the creative problem-solving process. During the exercise, participants were given a threat scenario and time with an unconstrained AI tool to evaluate an idea and generate a revised one. Input messages from the AI tool were collected and analyzed. In doing so, participants used AI prompts related to three core phases of the creative problem-solving process: information gathering, idea generation, and idea evaluation. This reveals that AI is used for various purposes, above …

A New Approach To Generate Combinatorial Patterns In Logical Analysis Of Data And Its Application To Predict College Retention, Salihah Ahmed E. Jaafari

Theses and Dissertations

Student retention and degree completion remain central challenges for higher-education institutions, with significant implications for student success, institutional effectiveness, and public accountability. While advances in predictive analytics have enabled earlier identification of students at risk of withdrawal, many commonly used machine learning approaches suffer from limited interpretability, constraining their practical usefulness for advising, intervention, and policy decision making. This dissertation addresses the problem of predicting student persistence by developing and evaluating optimization based, interpretable classification models within the Logical Analysis of Data (LAD) framework. Building on existing LAD formulations, this research introduces two novel pattern generation models, the Best Term …

Design And Simulation Of Anti-Resonant Hollow-Core Fiber For Sensing Applications, Pravallika Kante

Theses and Dissertations

This thesis presents the design and simulation of an 8-tube single-ring anti-resonant hollow-core fiber for sensing applications, with particular emphasis on methane gas detection at the fundamental absorption wavelength of 3.3 µm. Conventional solid-core silica optical fibers exhibit strong multi-phonon material absorption beyond 2.5 µm, rendering them fundamentally unsuitable for efficient light guidance and direct gas sensing at mid-infrared wavelengths. Anti-resonant hollow-core fibers overcome this limitation by guiding light predominantly through an air-filled hollow core via the anti-resonant reflecting optical waveguide mechanism, in which the thin silica glass walls of the cladding tubes act as Fabry-Pérot etalons that confine the …

Moon Adaptive Technology For Extraterrestrial Architectural Robotics (Matear), Candela Noemi Solis Zampini

Theses and Dissertations

The Moon Adaptive Technology for Extraterrestrial Architectural Robotics (MATEAR) focuses on the development of an autonomous robotic system capable of providing structural building blocks directly from lunar regolith. As a sustained human presence on the Moon becomes a necessity, the costly and limited payload capacity associated with transporting construction goods from Earth creates a critical challenge. MATEAR addresses this problem through in-situ resource utilization (ISRU), integrating a regolith processing system onto a remote operated vehicle. The proposed system is designed to collect lunar dust, mechanically compact the material, and apply thermal treatment to enhance cohesion through sintering. These regolith-made bricks …

Defining Civil Rico's "Injury To Business Or Property" Requirement: The Supreme Court Takes A Few Steps, Says It Punts, But Actually Fumbles, Randy D. Gordon

Faculty Scholarship

Throughout its history, the RICO statute has presented lawyers with something of an interpretive parlor game. It is indefinite along multiple dimensions and thereby given multiple interpretations, even down to the word level. In Medical Marijuana v. Horn, the Supreme Court set out to define one of RICO's civil-standing provisions: Namely, whether the statute's "injury to business or property" requirement can be satisfied when a plaintiff suffers both economic and personal injuries. In a 5-4 decision, members of the Court engaged in an interpretive battle over the meaning of the phrase and succeeded only in holding that civil RICO does …

Climate Lies And Unjust Profits, Vanessa Casado-Pérez, Yotam Kaplan, Yael Lifshitz, Niv Meyerson

Faculty Scholarship

The climate crisis has reached a perilous tipping point. Our entrenched reliance on fossil fuels remains unchecked, as fossil fuel corporations wield their power to block meaningful reform and entrench their profits. The political horizon offers little relief—an incoming administration is poised to dismantle vital environmental protections, stripping away the few safeguards that stand between us and climate catastrophe.

In this grim landscape, communities across the nation are turning to the courts with renewed urgency, seeking justice and reform through climate litigation. Yet past efforts have fallen short, stymied by two formidable barriers. First, by centering on greenhouse gas emissions …

Plea Bargain Skepticism When Companies Kill People, Peter R. Reilly

Faculty Scholarship

In 2018 and 2019, two Boeing 737 MAX airplanes fell from the sky, killing 346 people—one of the deadliest corporate crimes in U.S. history. Instead of taking the case to trial, the United States Department of Justice (“DOJ”) addressed the matter by using two different alternative dispute resolution vehicles. First, Boeing was given a three-year deferred prosecution agree-ment. That deal was canceled when DOJ determined the company had breached it. Next, Boeing was given a plea bargain. This Article argues that federal courts, which are empowered to approve or reject plea deals, should be skeptical when the government turns to …

Fifty Ways To Leave Your Lover: Using State Constitutions To Escape The Dead Hand Of Article V, Meg Penrose

Faculty Scholarship

Thomas Jefferson believed that “the earth always belongs to the living generation.” His constitutional approach would empower twenty-first century Americans to decide twenty-first century problems regularly determined by the United States Supreme Court. Article V, the formal method for constitutional change, seemingly relegates these decisions to the Supreme Court because amending the federal Constitution is nearly impossible.

Unfortunately, our fixation on federal constitutional law often eclipses the power of state constitutional law. State constitutions balance our relatively static federal Constitution with responsive state governments. There is no need to debate what the Framers thought about modern issues when Americans can …

Court-Stripping, Court-Packing, And Court Defying: Revisiting The Supreme Court’S Essential Functions, Curtis A. Bradley, Neil S. Siegel

Faculty Scholarship

The "essential functions thesis" is one of the most famous structural arguments in the field of federal courts. The thesis, which has been endorsed by a number of prominent scholars and the executive branch, posits that there are implicit, structural limits on Congress's authority to "strip" the Supreme Court of its appellate jurisdiction. Court-stripping, the thesis contends, is not allowed if it would undermine the essential functions of the Court-in particular, maintaining the supremacy and uniformity of federal law. In this Article, we revisit that thesis with three goals in mind. First, we aim to show that the structural arguments …

How Ai Destroys Institutions, Woodrow Hartzog, Jessica Silbey

Faculty Scholarship

Civic institutions—the rule of law, universities, and a free press—are the backbone of democratic life. They are the mechanisms through which complex societies encourage cooperation and stability, while also adapting to changing circumstances. The real superpower of institutions is their ability to evolve and adapt within a hierarchy of authority and a framework for roles and rules, while maintaining legitimacy for the knowledge produced and the actions taken. Purpose-driven institutions built around transparency, cooperation, and accountability empower individuals to take intellectual risks and challenge the status quo. This happens through the machinations of interpersonal relationships within those institutions, which broaden …

Revocation Reconsidered: Probation Advocacy Through A Litigation Lens, Shira M. Diner

Faculty Scholarship

Being found in violation of probation has dire consequences. The person found in violation can be imprisoned, upending them from their job, family, and community. Unlike incarceration after a criminal trial, a sentence after a violation of probation is not the result of a legal process characterized by robust due process protections. It is also often not the result of a forceful and thorough defense. It is instead the consequence of a hearing where lawyers with the fixed mindset of an inevitable finding of a violation don’t engage in the same preparation that they would if it was a trial. …

Antidiscrimination, Not Anti-Dei: The Real Story Of The Supreme Court's Recent Title Vii Precedent, Madeline H. Meth

Faculty Scholarship

For several years, my colleague and I had been litigating employment discrimination cases with facts that shocked our friends and family. For example, we fought Dallas County over a women-work-the-weekend policy that required women detention officers to work weekends while male colleagues took the weekends off. Likewise, we challenged the City of Cleveland when it moved our client, an emergency medical services supervisor, from the day shift to the night shift explicitly because he is Black. Then, in April 2024, in one of our client’s cases, Muldrow v. City of St. Louis, the U.S. Supreme Court unanimously overruled the …

Attachment And Betrayal: Post-Infidelity Attachment Issues With A Focus On Gender, Taylor Forsythe

Electronic Theses and Dissertations

Infidelity represents a significant relational trauma that may disturb attachment processes such as trust, emotional intimacy, and closeness. There is a gap in the literature on how different infidelity exposures may relate to these attachment responses; more so, there is a dearth of information on the gender differences for attachment issues following any kind of infidelity. The purpose of this study aimed to examine differences in avoidant and anxious attachment across infidelity groups (no infidelity, non-sexual infidelity, sexual infidelity), and a further comparison of gender differences in those groups. Participants (N = 151) completed online surveys in a larger study …