Digital Commons Network^™

Identification Of Dual Strn-Ntrk2 Rearrangements In A High Grade Sarcoma, With Good Clinical Response To First-Line Larotrectinib Therapy, Ruihe Lin, Atrayee Basu Mallick, Zi-Xuan Wang, Phd, Scot Andrew Brown, Bo Lu, Md, Wei Jiang

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

BACKGROUND: Among the three NTRK genes, NTRK2 possesses a tremendous structural complexity and involves tumorigenesis of several types of tumors. To date, only STRN and RBPMS are identified in the fusion with NTRK2 in adult soft tissue tumors. More recently, the highly selective Trk tyrosine kinases inhibitors, including larotrectinib and entrectinib, have shown significant efficacy for treating tumors harboring NTRK fusions and were approved by FDA.

CASE PRESENTATION: We report a case of sarcoma in a 35-year-old female harboring two STRN-NTRK2 gene fusions, with a good clinical response to first-line larotrectinib treatment. Core biopsy of the 16.5 cm gluteal mass …

A Queered Exhibition: Lgbtqia+ Artists Expressing Identity And Visibility Through Art-Based Research, Christy D. Paris

USF Tampa Graduate Theses and Dissertations

Too often museums, galleries, and art curriculum ignore or erase the lives and art of LGBTQIA+ individuals. This exhibition aimed to make the diverse lives and art from the queer community visible. Integrating queer perspectives and visibility is empowering and creates a sense of belonging. Queering the art world can present alternative perspectives, promote diversity, and provide exposure to a more inclusive experience for all. The aim of this inquiry is to inform institutional practices within museums on queer inclusivity and further scholarship on this topic by engaging with the queer art community and public during an exhibition held in …

The Involvement Of Caspases In The Process Of Nuclear Removal During Lens Fiber Cell Differentiation, Rifah Gheyas, A. Sue Menko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

The terminal differentiation of lens fiber cells involves elimination of their organelles, which must occur while still maintaining their functionality throughout a lifetime. Removal of non-nuclear organelles is accomplished through induction of autophagy following the spatiotemporal suppression of the PI3K/Akt signaling axis. However, blocking this pathway is not alone sufficient to induce removal of fiber cell nuclei. While the final steps in fiber cell nuclear elimination are highlighted by the appearance of TUNEL-positive nuclei, which are associated with activation of the lens-specific DNaseIIβ, there are many steps in the process that precede the appearance of double stranded DNA breaks. We …

Further Refinement Of The Differentially Methylated Distant Lung-Specific Foxf1 Enhancer In A Neonate With Alveolar Capillary Dysplasia, Przemyslaw Szafranski, Rijutha P Garimella, Haresh Mani, Ryan Hartman, Gail Deutsch, Alan Silk, Alan Benheim, Paweł Stankiewicz

Faculty, Staff and Students Publications

Heterozygous SNVs or CNV deletions involving the FOXF1 gene, or its distant enhancer, are causative for 80-90% of cases of alveolar capillary dysplasia with misalignment of pulmonary veins. Recently, we proposed bimodal structure and parental functional dimorphism of the lung-specific FOXF1 enhancer, with Unit 1 having higher activity on the paternal chr16 and Unit 2 on the maternal chr16. Here, we describe a novel unusually sized pathogenic de novo copy-number variant deletion involving a portion of the FOXF1 enhancer on maternal chr16 that implies narrowing Unit 2 to an essential ~ 9-kb segment. Using a restrictase-based assay, we found that …

Negative Estrangement: Fantasy And Race In The Drow And Drizzt Do’Urden, Steven Holmes

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

This essay introduces the concept of negative estrangement to help understand current cultural interventions into the norms of depicting fantasy races. First, this essay builds on Shklovsky’s concept of estrangement to describe the literary practice of negative estrangement, wherein artists craft “more evil” foes based on hybridized amalgamations of stereotypes to create antipathy toward a subject, be it monster or fantasy race. This practice is sometimes used in service of confronting the issue of race and racism, despite seeming to reify or rearticulate racist stereotypes.

This essay builds on Tolkien’s argument in favor of creating “more evil” foes to exemplify …

"A Bleak, Barren Land": Women And Fertility In The Lord Of The Rings, Dylan L. Henderson

Mythlore: A Journal of J.R.R. Tolkien, C.S. Lewis, Charles Williams, and Mythopoeic Literature

Critics, and even the general public, have noted the absence of women in The Lord of the Rings, an absence so glaring that it could hardly be overlooked. Many feminist scholars have, as a result of this deficiency, denounced J.R.R. Tolkien, interpreting this lack of female characters as indicative of repressed misogyny. Others, however, have defended the author, pointing out that the female characters that do exist could be considered role models. This essay offers an alternative interpretation and contends that the absence of women in the novel, though potentially reducing its appeal to modern readers, reinforces one of …

Photocurable Ionized Vinylimidazole Liquid Salt For Antibacterial Application, Gina Park, Lisa Ahlberg, Robert Zdor

Celebration of Research and Creative Scholarship

There has been an increasing demand for antibacterial dental composite as it can prevent the biofilm formation and the adhesion of bacteria after the treatment causing the consequential cavities. Previous study explored the antibacterial activity of the heterogenous mixture of heterocyclic polymer and resin. It showed limitations as the mixture did not show antibacterial activity since the mixture could only contain a small amount of heterocyclic polymer within the resin due to its inconvenience of shaping and low miscibility. To overcome this limitation, this research focused on synthesizing heterocyclic antibacterial monomer liquid salt and curing it with UV light to …

Play And Higher Education: Incorporating Playfulness In The College Classroom, Alicia Cater

Together We RISE (Making Excellence Inclusive)

No abstract provided.

What Do We Do With You: How The United States Uses Racial-Gendered Immigrant Labor To Inform Its Immigrant Inclusion-Exclusion Cycle, Tori Delaney

University of Cincinnati Law Review

No abstract provided.

School Matters, Ronna Greff Schneider

University of Cincinnati Law Review

No abstract provided.

Minutes, October 2023, University Of Dayton. College Of Arts And Sciences

Documents of the College of Arts and Sciences Academic Affairs Committee

Minutes from organizational meeting for Academic Affairs Committee

Medical School Watercooler Newsletter - October 20, 2023, Lindsey Lyle

Watercooler Newsletter

This is the October 20, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Carnes returns to USA after 15 years of clinical experience
• Distinguished Scientists Seminar set for Nov. 2
• GHHS and Wellness council to host Art of medicine event
• Mayer Mitchell Award to be presented to cancer researcher
• Mark Your calendar: Randall W. Powell Endowed Memorial Lectureship
• Register now: 7th Annual Conference on Ethics and Opioids
• OB-GYN interest group to host DEI movie night
• USA health game day celebrates employees
• Dadlani named professor and chair of pediatrics

Universal Aspects Of Barrier Crossing Under Bias, Sudeep Adhikari, Kevin S. D. Beach

Faculty and Student Publications

The thermal activation process by which a system passes from one local energy minimum to another is a recurring motif in physics, chemistry, and biology. For instance, biopolymer chains are typically modeled in terms of energy landscapes, with folded and unfolded conformations represented by two distinct wells separated by a barrier. The rate of transfer between wells depends primarily on the height of the barrier, but it also depends on the details of the shape of the landscape along the trajectory. We consider the case of bias due to an external force, analogous to the pulling force applied in optical …

A 3d-Printed Blood-Brain Barrier Model With Tunable Topology And Cell-Matrix Interactions., Louis S Paone, Mohammed Mehdi Benmassaoud, Aidan Curran, Sebastián L Vega, Peter A Galie

Henry M. Rowan College of Engineering Departmental Research

Recent developments in digital light processing (DLP) can advance the structural and biochemical complexity of perfusable in vitro models of the blood–brain barrier. Here, we describe a strategy to functionalize complex, DLP-printed vascular models with multiple peptide motifs in a single hydrogel. Different peptides can be clicked into the walls of distinct topologies, or the peptide motifs lining channel walls can differ from those in the bulk of the hydrogel. The flexibility of this approach is used to both characterize the effects of various bioactive domains on endothelial coverage and tight junction formation, in addition to facilitating astrocyte attachment in …

Dna Analysis: The Answer For Unsolved Cases?, Sarah Hetchler

Master of Arts in Criminal Justice Leadership

DNA analysis has become a crucial part of solving cases. It has developed significantly since its creation in the mid-1980s. The longing for answers within unsolved cases is historically lengthy, leaving traces of distrust and injustice. Criminologists offer a potential solution to the mess created by connecting DNA analysis to protect victims and communities. DNA evidence and analysis can assist in solving cases and provide answers for exonerees. Like public genealogy websites, law enforcement agencies must acknowledge new methods to solve issues. Not only could law enforcement agencies solve and arrest suspects through DNA analysis, but DNA could also provide …

Recipient Of The 2023 Alumni Titan Award, Dr. Angel Alvarez ‘98

Alumni Titan Award

Dr. Angel Alvarez ‘98

Dr. Angel Alvarez is the Director of the Stem Cell Core and a Research Assistant Professor in the Department of Neurology at Northwestern University. He has extensive experience in stem cell biology, imaging, gene delivery, and biotechnology. As the Director of the Northwestern Stem Cell Core, he establishes disease models to accelerate therapeutic development using organoid technology and patient-derived induced pluripotent stem cells. Many of the most rewarding aspects of his current position are derived from the Core’s exciting collaborations in reproductive biology, neuroscience, and pathology. Beyond his lab research, Dr. Alvarez has a passion for …

Recipient Of The 2023 Alumni Distinguished Leadership Award, Capt. Elizabeth “Spike” Malecha '90

Alumni Distinguished Leadership Award

Capt. Elizabeth “Spike” Malecha ‘90

Elizabeth Malecha is an accomplished military officer dedicated to service and leadership.

After graduating from the United States Naval Academy in 1994, she was in the first wave of women allowed to defend our nation in combat military roles. After completing flight training, she became a Radar Intercept Officer in the F-14 Tomcat. Flying missions from aircraft carriers across the world, she developed as a leader and a combat aviator in support of our national objectives and defense. Her talent and work ethic resulted in her selection for elite training at the U.S. Navy Fighter …

Volume 1, Issue 8, Bryant University

Bryant Bulldog Bulletin (2023-2024)

No abstract provided.

The Effect Of An Electric Current On Human Body (A Review), Yasir Khaleel Almusawi, Maha Raad Hashim Al-Sammarraie, Mukaram D. Shikara

Al-Esraa University College Journal for Medical Sciences

According to the World Health Organization (WHO), four people are killed every week by electrocution in the last decade, while 3% of people (suffering from electrical injuries) were admitted to emergency wards. The severity of electric injury depends on the electrical resistance of the human body, which depends on several factors such as the long duration of electric contact, type of the current (AC or DC), intensity of the current (amperes/voltages), sites of entry and exit points, wet or dry body, individual metabolism of the person, sweat gland activity, human body mass, type of tissue it travels through and its …

Biological Activity Of Rats Treated With Riboflavin In Polymeric Plga As Injectable Form, Sarah A. Hamood, Jabar A. Faraj, Ziad T. Al-Dahan

Al-Esraa University College Journal for Medical Sciences

The current study aims to optimize a fast, reproducible, reliable, and effective technique for estimating the biological activity of Vitamin B2 in injectable dose form using reversed-phase high-performance liquid chromatography (RP-HPLC). A biodegradable polymer, PLGA (Poly (lactic-co-glycolic acid) 50:50 type, approved as an active ingredient for parenteral administration, was used to load the vitamin in the injection volume of 1mg. Rats, both male and female, were employed as the animal models. Each animal was hosted for a duration of 40 days, and the activity of vitamin B2 was monitored at rapid intervals over six weeks using an HPLC device on …

Confirmation Report: Modelling Interlocutor Confusion In Situated Human Robot Interaction, Na Li

Reports

Human-Robot Interaction (HRI) is an important but challenging field focused on improving the interaction between humans and robots such to make the interaction more intelligent and effective. However, building a natural conversational HRI is an interdisciplinary challenge for scholars, engineers, and designers. It is generally assumed that the pinnacle of human- robot interaction will be having fluid naturalistic conversational interaction that in important ways mimics that of how humans interact with each other. This of course is challenging at a number of levels, and in particular there are considerable difficulties when it comes to naturally monitoring and responding to the …

Dragon Fruit Weight Estimation Based On Machine Vision And Machine Learning, Liang Ying-Kai, Shang Feng-Nan, Chen Qiao, Xiao Ming-Wei, Luo Chen-Di, Li Wen-Tao, Zhou Xue-Cheng

Food and Machinery

Objective: In order to solve the problem of manual weighting of dragon fruit, including time-consuming, laborious and expensive, an automated weight estimation method based on machine vision and machine learning was proposed in this research. Methods: Firstly, 106 dragon fruits were weighed, recorded and photographed, and images of dragon fruits were constructed. Secondly, binary images were obtained after denoising and segmentation. Moreover, the three features of pixel area, major axis pixel length and minor axis pixel length of dragon fruits were extracted on the basis of binary images. The three features of each image and their corresponding weights were combined …

Research Progress Of Peanut Allergenicity Assessment Methods And The Effect Of Food Processing On Its Allergenicity, Chen Kuan, Wang Tao, Li Qian, Jiang Songsong

Food and Machinery

Peanut is one of the "Big Eight" allergen foods. It has been noticed by public due to its serious clinical symptoms and high incidence rate. This review introduced structures and immune characteristics of peanut allergens (Ara h 1-18). The assessment methods (both in vitro and in vivo) was also introduced. Finally, the research progress of different food processing on the allergenicity of peanut were summarized. The future research direction of food processing on reducing the allergenicity of peanut were prospected.

Advances In The Preparation, Structural Characterization And Biological Activity Of Glycosylated Peptides, Wu Ying, Qu Tingmin, Wen Shiyu, Wu Hao, Cheng Yunhui, Wen Li

Food and Machinery

The structure and function of peptides are affected by the changes of environmental factors, including temperature, pH value and ionic strength. Sugar groups can form covalent bonds with amino acid side chain groups of peptides to undergo structural modification, and then the glycosylation modification can effectively improve the stability and biological activity of peptide molecules. In this review, the preparation methods and structural characterization strategies of glycosylated peptides were summarized, and the recent research progress on their physiological activities were highlighted. The challenges and future research directions of glycosylated peptides were also discussed.

Protective Effect Of Eurotium Cristatum Fermentation Broth Mixed With Tea Polyphenols On Immunosuppressive Mice, Peng Ying

Food and Machinery

Objective: This study aimed to investigate the effect of Eurotium Cristatum fermentation broth mixed with tea polyphenols on the immune indexes of cyclophosphamide immunosuppressive mice. Methods: Immunosuppressive model was established by intraperitoneal injection of cyclophosphamide with 80 mg/kg for 3 days. High, middle and low dose E. Cristatum fermentation broth mixed with tea polyphenols was administrated to immunosuppressive mice intragastrically for 15 days. The blood index, spleen index, macrophage phagocytic index, half hemolysis value, delayed-type hypersensitivity, the content of IL-2 and tumor necrosis factor-α (TNF-α) were measured. Results: E. Cristatum fermentation broth mixed with tea polyphenols significantly …

Effects Of Different Processes On Active Components And Antioxidant Activities Of Akebia Trifoliate Seed Oil, Gao Xiaolong, Xu Wei, Li Ying, Zhou Min

Food and Machinery

Objective: To compare the effects of different oil preparation processes on the active ingredients and oxidation activity of Akebia trifoliate seed oil. Methods: Akebia trifoliata seed oil was prepared from Akebia trifoliata seed by four oil extraction processes: cold pressing, hot pressing, supercritical CO₂ extraction and extraction. The fatty acid composition, active ingredients （carotenoids, tocopherols, polyphenols, flavonoids） and DPPH free radical scavenging capacity of Akebia trifoliata seed oil were analyzed. Results: The fatty acid composition of Akebia trifoliata seed oil prepared by the four processes was similar. The content of palmitic acid was 20.62%～21.42%, the content of stearic acid …

Screening Of Autochthonouslactic Acid Bacteria And Optimization Of Fermentation Process In Low-Salt Zhayu Of Red Rice, Xu Dongmei, Liu Yongle, Li Xianghong, Wang Faxiang, Huang Yiqun, Ma Xiayin

Food and Machinery

Objective: To solve the problems of an uncertain fermentation process, a long fermentation period, and the unstable quality of traditional naturally fermented preserved fish. Methods: The lactic acid bacteria were isolated from low-salt preserved red fish, and the inhibition ability, salt tolerance, and acid production ability of the strains were investigated. The lactic acid bacteria suitable for fermentation were screened out, and the fermentation of preserved red fish was intensified by inoculation. The amount of red rice flour added, the amount of salt added during curing, and the fermentation temperature were optimized in the fermentation process. Results: There were 22 …

Fruit Identification Using Improved Faster R-Cnn Model, Jian Yanping, Sang Yanli, Li Yueru

Food and Machinery

Objective: To improve the identification accuracy of fruit categories. Methods: An identification method for fruit categories was established based on an improved Faster regional convolutional neural network （Faster R-CNN） model. Firstly, the regularization method was used to attenuate the weight of some high-dimensional parameters to effectively solve the over-fitting problem that may occur in the training process. Then, two loss functions, a likelihood function and a regularization function, were added to the Faster R-CNN framework to optimize the convolution layer and the pooling layer. Additionally, the least square method was utilized to solve the objective function of fruit recognition. Finally, …

Research On Moulded Peanut Recognition Technology Based On Deep Learning, Wang Weina, Xu Shiwei, Deng Qinbo, Li Bo

Food and Machinery

Objective: To identify mouldy peanuts in a fast and non-destructive way and improve the identification efficiency. Methods: Collected hyperspectral peanut data using a spectrometer, identify moldy peanuts using deep learning technology, and established a Hypernet PRMF model, which was compared with Deeplab v3+, Segnet, Unet, and Hypernet as control models. Integrated the proposed peanut recognition index into hyperspectral images as data feature pre extraction. Simultaneously integrating the constructed multi feature fusion blocks into the control model to improve the recognition efficiency of moldy peanuts. Results: The average pixel accuracy of all models exceeded 87%. the Hypernet-PRMF model had the highest …

Study On Flash Extraction Technology And Antioxidant Activity Of Polysaccharides From Fresh Lentinus Edodes Stalk, Shi Guoqing, Yang Linxiao, Li Meijuan, Kong Na, Jia Huanhuan, Shi Li

Food and Machinery

Objective: Develop the industrial production of Lentinus edodes stalk polysaccharides. Methods: Using the yield of polysaccharides as an indicator, uniform design experiments were used to optimize the extraction process parameters. Four methods were used to determine the antioxidant activity of polysaccharides and compared with the traditional hot water extraction method. Results: The optimal process conditions for the flash-assisted extraction of Lentinus edodes stalk polysaccharides were as follows: flash extraction time 120 s, ratio of liquid to material 40∶1 （mL/g）, hot water extraction time 105min, temperature 50 ℃, extraction twice. Under these conditions, the yield of polysaccharides was （5.03±0.22）%, which was …