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Articles 99841 - 99870 of 819612
Full-Text Articles in Entire DC Network
Forest Composition Change And Biophysical Climate Feedbacks Across Boreal North America, Richard Massey, Brendan M. Rogers, Logan T. Berner, Sol Cooperdock, Michelle C. Mack, Xanthe J. Walker, Scott J. Goetz
Forest Composition Change And Biophysical Climate Feedbacks Across Boreal North America, Richard Massey, Brendan M. Rogers, Logan T. Berner, Sol Cooperdock, Michelle C. Mack, Xanthe J. Walker, Scott J. Goetz
Aspen Bibliography
Deciduous tree cover is expected to increase in North American boreal forests with climate warming and wildfire. This shift in composition has the potential to generate biophysical cooling via increased land surface albedo. Here we use Landsat-derived maps of continuous tree canopy cover and deciduous fractional composition to assess albedo change over recent decades. We find, on average, a small net decrease in deciduous fraction from 2000 to 2015 across boreal North America and from 1992 to 2015 across Canada, despite extensive fire disturbance that locally increased deciduous vegetation. We further find near-neutral net biophysical change in radiative forcing associated …
October 25, 2023, Faculty, Illinois Wesleyan University
October 25, 2023, Faculty, Illinois Wesleyan University
2023-2024
No abstract provided.
Turn-On Rhodamine Glycoconjugates Enable Real-Time Glut Activity Monitoring In Live Cells And In Vivo, Monica M.S. Nyansa, Adelina Oronova, Nazar Gora, Micaela Rayne Geborkoff, Nathan Ostlund, Delaney Fritz, Thomas Werner, Marina Tanasova
Turn-On Rhodamine Glycoconjugates Enable Real-Time Glut Activity Monitoring In Live Cells And In Vivo, Monica M.S. Nyansa, Adelina Oronova, Nazar Gora, Micaela Rayne Geborkoff, Nathan Ostlund, Delaney Fritz, Thomas Werner, Marina Tanasova
Michigan Tech Publications
The direct relationship between facilitative glucose transporters (GLUTs) and metabolic diseases opens new avenues for sensing metabolic deregulations and drives the development of molecular probes for GLUT-targeted detection of metabolic diseases. Radiotracer-based molecular imaging probes have been effectively utilized in reporting alterations in sugar uptake as an indication of metabolic deregulations, cancer development, or inflammation. Progress in developing fluorophore-based tools facilitated GLUT-specific analyses using more accessible fluorescence-based instrumentation. However, restrictions on the emission range of fluorophores and the requirement for substantial post-treatments to reduce background fluorescence have brought to light the critical directions for improvement of the technology for broader …
User Experience Personas Fall 2023, Simon C. Marcy
User Experience Personas Fall 2023, Simon C. Marcy
Library Assessment and Statistics
UX personas are fictional representations of key user segments, typically based on research and data, used to guide design decisions by humanizing and providing insights into the needs, goals, and behaviors of target users.
Are We There Yet?, Marion S. Freistadt
Are We There Yet?, Marion S. Freistadt
LSU Master's Theses
To solve the Climate Crisis, a global Energy Transition is required. The primary contemporary tool for tackling these two massive problems is modeling, both biophysical climate models and IAMS (Integrated Assessment Models) which combine socioeconomic and technological progress with Climate Change. However, the proliferation and complexity of modeling systems make it difficult for most people to contribute substantively to solutions. In particular, stakeholders, policymakers, nonspecialists and activists require sufficient understanding of modeling to impact outcomes.
In this thesis, after summarizing the Climate Crisis and potential Energy Transition solutions, I review current modeling approaches. Models can be considered in terms of …
An Exploration Of Complementary And Alternative Medicine Usage Within The Vietnamese Community In Lincoln, Nebraska, Helen Duong
An Exploration Of Complementary And Alternative Medicine Usage Within The Vietnamese Community In Lincoln, Nebraska, Helen Duong
Honors Program: Senior Projects (Public)
Lincoln, Nebraska is home to over 5,000 Vietnamese refugees and immigrants, many of whom practice complementary and alternative medicine (CAM) as a result of healing traditions passed down through family members. This thesis explores the use of CAM among the Vietnamese population of Lincoln. The study employs an analysis of the literature on CAM among Vietnamese populations and thematic analysis of interviews conducted with members of the Vietnamese community of Lincoln, NE. Interviews explore perceptions of healthcare quality and access within this community as well as investigate the link between CAM and allopathic (Western) medicine. Findings suggest that certain CAM …
Momentary Shame & Executive Function: Negative Self-Attribution As A Precursor To Performance Error, Mary M. Bryan
Momentary Shame & Executive Function: Negative Self-Attribution As A Precursor To Performance Error, Mary M. Bryan
Master's Theses & Other Graduate Student Works
Individuals who experience momentary shame experiences may attribute a sense of wrongdoing to their identity. Witnessing one's violation of social mores may promote withdrawal, rumination, and/or aggression, which may restrict cognitive processes that affect typical executive function. In particular, task initiation, inhibition, and cognitive flexibility were selected when measuring levels of executive dysfunction. 10 participants were asked to complete shame and executive function pre-screeners, a shame- or neutral-affective writing task, and a real-time executive function measure. Results suggest that those who self-reported higher levels of shame proneness and underwent a shame-affective stimulus may have displayed improved inhibition and cognitive flexibility. …
Re‑Using Food Resources From Failed Honey Bee (Apis Mellifera L.) Colonies And Their Impact On Colony Queen Rearing Capacity, Rogan Tokach, Autumn H. Smart, Judy Wu-Smart
Re‑Using Food Resources From Failed Honey Bee (Apis Mellifera L.) Colonies And Their Impact On Colony Queen Rearing Capacity, Rogan Tokach, Autumn H. Smart, Judy Wu-Smart
Department of Entomology: Faculty Publications
For over a decade, beekeepers have experienced high losses of honey bee (Apis mellifera L.) colonies due to a variety of stressors including pesticide exposure. Some of these chemical stressors may residually remain in the colony comb and food resources (pollen and nectar) of failed colonies and be later re-used by beekeepers when splitting and building back new colonies. The practice of re-using comb from previously perished colonies (termed “deadout”) is common in beekeeping practice, but its role in affecting colony health is not well understood. Here, we evaluate the impact of reused, pesticide-contaminated “deadout” combs on colony function …
Causal Models And Causal Modelling In Obesity: Foundations, Methods And Evidence, Roger S Zoh, Xiaoxin Yu, Philip Dawid, George Davey Smith, Stephen J French, David B Allison
Causal Models And Causal Modelling In Obesity: Foundations, Methods And Evidence, Roger S Zoh, Xiaoxin Yu, Philip Dawid, George Davey Smith, Stephen J French, David B Allison
Children’s Nutrition Research Center Staff Publications
Discussing causes in science, if we are to do so in a way that is sensible, begins at the root. All too often, we jump to discussing specific postulated causes but do not first consider what we mean by, for example, causes of obesity or how we discern whether something is a cause. In this paper, we address what we mean by a cause, discuss what might and might not constitute a reasonable causal model in the abstract, speculate about what the causal structure of obesity might be like overall and the types of things we should be looking …
Tyramine And Its Amtyr1 Receptor Modulate Attention In Honey Bees (Apis Mellifera), Joseph S. Latshaw, Reece E. Mazade, Mary Petersen, Julie A. Mustard, Irina Sinakevitch, Lothar Wissler, Xiaojiao Guo, Chelsea Cook, Hong Lei, Brian Smith
Tyramine And Its Amtyr1 Receptor Modulate Attention In Honey Bees (Apis Mellifera), Joseph S. Latshaw, Reece E. Mazade, Mary Petersen, Julie A. Mustard, Irina Sinakevitch, Lothar Wissler, Xiaojiao Guo, Chelsea Cook, Hong Lei, Brian Smith
School of Integrative Biological & Chemical Sciences Faculty Publications
Animals must learn to ignore stimuli that are irrelevant to survival and attend to ones that enhance survival. When a stimulus regularly fails to be associated with an important consequence, subsequent excitatory learning about that stimulus can be delayed, which is a form of nonassociative conditioning called ‘latent inhibition’. Honey bees show latent inhibition toward an odor they have experienced without association with food reinforcement. Moreover, individual honey bees from the same colony differ in the degree to which they show latent inhibition, and these individual differences have a genetic basis. To investigate the mechanisms that underly individual differences in …
The Rider (2023-10-23), Natalie Lapsley
3d Musculoskeletal Analysis Of The Rhea Americana Forelimb And Implications For The Evolution Of Avian Flight, Sarah Elizabeth Guzinski
3d Musculoskeletal Analysis Of The Rhea Americana Forelimb And Implications For The Evolution Of Avian Flight, Sarah Elizabeth Guzinski
USF Tampa Graduate Theses and Dissertations
To understand the evolutionary gain, and loss, of avian powered flight, attention must be paid to the wing morphology of species across these transitions. However, paleognaths, while being the most well-known flightless birds, have greatly understudied forelimbs. Additionally, current literature regarding their forelimb anatomy generally lacks a three-dimensional (3D), biomechanical approach. Among the flightless paleognaths, the rhea is notable in having the least reduced forelimb. Though not used for flight, the wings of rheas are used in other behaviors such as courtship and threat display, as well as nest defense. In this study, I investigate the forelimb anatomy of an …
Stable Isotope Analysis On Yellowfin And Blackfin Tuna Eye Lenses Reveals Life History Patterns In The Gulf Of Mexico, Kylee M. Rullo
Stable Isotope Analysis On Yellowfin And Blackfin Tuna Eye Lenses Reveals Life History Patterns In The Gulf Of Mexico, Kylee M. Rullo
USF Tampa Graduate Theses and Dissertations
Spatial geography, ontogenetic movement, and trophic patterns of mobile species are key elements of effective marine resource management. A number of methods are currently available for tracking movements of pelagic migratory species, including the use of conventional and electronic tags. However, tagging campaigns can take years to provide useful data, can be expensive, and only capture a portion of a fish’s lifetime. For this project, I used stable-isotopic ratios of nitrogen (δ15N) and carbon (δ13C) in metabolically inert, chronologically-layered fish-eye lenses to explore lifetime movement and trophic patterns of yellowfin tuna (Thunnus albacares) and blackfin tuna (Thunnus atlanticus) in the …
Semi-Structured Interview Transcripts Of Fishing Gear Recyclers, Amanda Burton
Semi-Structured Interview Transcripts Of Fishing Gear Recyclers, Amanda Burton
Faculty of Science and Engineering Datasets
The study was conducted by Amanda Burton for a thesis entitled 'Towards a Circular Economy for Fishing Gear', submitted in partial fulfilment of the requirements for the degree of MSc Advanced Engineering Design, University of Plymouth, Faculty of Science and Engineering, Sept 2021. The study was in collaboration with the Interreg INdIGO project 2019-2023. Dataset Description: Transcripts of four interviews conducted with individuals engaged in recycling of End of Life and recovered Abandoned, Lost and Discarded fishing gear. Citation: Burton, A. (2023). Semi-structured interview transcripts of fishing gear recyclers. PEARL Research Repository. https://doi.org/10.24382/k17a-mh85.
The George-Anne Inkwell Edition, Georgia Southern University
The George-Anne Inkwell Edition, Georgia Southern University
The Inkwell
No abstract provided.
Dual Targeted Extracellular Vesicles Regulate Oncogenic Genes In Advanced Pancreatic Cancer, Chi-Ling Chiang, Yifan Ma, Ya-Chin Hou, Junjie Pan, Sin-Yu Chen, Ming-Hsien Chien, Zhi-Xuan Zhang, Wei-Hsiang Hsu, Xinyu Wang, Jingjing Zhang, Hong Li, Lili Sun, Shannon Fallen, Inyoul Lee, Xing-Yu Chen, Yeh-Shiu Chu, Chi Zhang, Tai-Shan Cheng, Wen Jiang, Betty Y S Kim, Eduardo Reategui, Robert Lee, Yuan Yuan, Hsiao-Chun Liu, Kai Wang, Michael Hsiao, Chi-Ying F Huang, Yan-Shen Shan, Andrew S Lee, L James Lee
Dual Targeted Extracellular Vesicles Regulate Oncogenic Genes In Advanced Pancreatic Cancer, Chi-Ling Chiang, Yifan Ma, Ya-Chin Hou, Junjie Pan, Sin-Yu Chen, Ming-Hsien Chien, Zhi-Xuan Zhang, Wei-Hsiang Hsu, Xinyu Wang, Jingjing Zhang, Hong Li, Lili Sun, Shannon Fallen, Inyoul Lee, Xing-Yu Chen, Yeh-Shiu Chu, Chi Zhang, Tai-Shan Cheng, Wen Jiang, Betty Y S Kim, Eduardo Reategui, Robert Lee, Yuan Yuan, Hsiao-Chun Liu, Kai Wang, Michael Hsiao, Chi-Ying F Huang, Yan-Shen Shan, Andrew S Lee, L James Lee
Faculty, Staff and Student Publications
Pancreatic ductal adenocarcinoma (PDAC) tumours carry multiple gene mutations and respond poorly to treatments. There is currently an unmet need for drug carriers that can deliver multiple gene cargoes to target high solid tumour burden like PDAC. Here, we report a dual targeted extracellular vesicle (dtEV) carrying high loads of therapeutic RNA that effectively suppresses large PDAC tumours in mice. The EV surface contains a CD64 protein that has a tissue targeting peptide and a humanized monoclonal antibody. Cells sequentially transfected with plasmid DNAs encoding for the RNA and protein of interest by Transwell®-based asymmetric cell electroporation release abundant targeted …
A Framework To Validate Fluorescently Labeled Dna-Binding Proteins For Single-Molecule Experiments, Miranda Molina, Lindsey E. Way, Zhongqing Ren, Qin Liao, Bianca Guerra, Brandon Shields, Xindan Wang, Hyeongjun Kim
A Framework To Validate Fluorescently Labeled Dna-Binding Proteins For Single-Molecule Experiments, Miranda Molina, Lindsey E. Way, Zhongqing Ren, Qin Liao, Bianca Guerra, Brandon Shields, Xindan Wang, Hyeongjun Kim
Physics & Astronomy Faculty Publications
Highlights
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KCK tag can alter protein properties both quantitatively and qualitatively
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Electrostatic interactions between the KCK tag and DNA contribute to the artifacts
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Adding a short peptide tag to ParB protein does not lead to its in vivo changes
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Single-molecule DNA flow-stretching assay can detect protein property changes
Motivation
Single-molecule fluorescence microscopy has been extensively used in modern biology to define the molecular action of proteins. Appending short peptide tags is a common strategy to enhance fluorescence labeling. Here, we evaluate the impact of a commonly used tag, the lysine-cysteine-lysine (KCK) tag, on protein behavior in single-molecule DNA flow-stretching assay, …
Chimes: October 23, 2023, Calvin University
Chimes: October 23, 2023, Calvin University
Chimes
Calvin approves purchase of new equipment for film and media department by Savannah Shustack
Students and faculty navigate new schedule after transition to four-two credit system by Ethan Meyers
CCW hosts panel on adoption, starts new adoptee support program by Ashley Hamons
Geo department leads coastal cleanup by Maya Oeverman
Muslim students, few in number, engage questions about Islam and Christianity by Nolan Cowan
Disability support workers are not inherently more virtuous than other workers by Grace Buller
Is A Psychotic Anthropology Possible? Or How To Have Inclusive Anthropologies Of Subjectivity And Personhood, John Marlovits, Matthew J. Wolf-Meyer
Is A Psychotic Anthropology Possible? Or How To Have Inclusive Anthropologies Of Subjectivity And Personhood, John Marlovits, Matthew J. Wolf-Meyer
Faculty Research, Scholarly, and Creative Activity
Dominant anthropological theories of mind, cognition, and consciousness reify particular ways of being in the world as "normal," which marginalizes the experiences of people who do not meet normative expectations of personhood or exhibit nonnormative subjectivities. By focusing on atypical forms of communication and self-representation in the ethnographic record, which draws from work in the anthropology of disability and psychological anthropology, we argue for the need to attend to interactions and behavior as the necessary basis for anthropological studies of personhood and subjectivity. These foci, which build on a foundation provided by affect theory and disability studies, stand to open …
Appropriate And Optimal Classifier For Beef Quality Discrimination By A Low-Cost Optical Apparatus, Said E. Abdallah, Wael M. Elmessery, Waleed Z. Hassan, Nora S. Al-Sattary, Amr A. Abohany, Ahmed Elashry
Appropriate And Optimal Classifier For Beef Quality Discrimination By A Low-Cost Optical Apparatus, Said E. Abdallah, Wael M. Elmessery, Waleed Z. Hassan, Nora S. Al-Sattary, Amr A. Abohany, Ahmed Elashry
Information Sciences Letters
In this paper, we present an optimal classifier for beef quality discrimination by a low-cost optical apparatus. Detecting beef spoilage in beef factories is a sophisticated process because beef spoilage is a mixture of physical and chemical changes. A low-cost Light-Dependent Resistor (LDR), and a light source were used to collect reflection spectra during the analysis of beef. The LabVIEW platform was programmed to acquire the obtained data from the microcontroller (Arduino) to predict beef quality. For the beef quality discrimination process, un-supervising machine learning called Principal Components Analysis (PCA) was used, and the score plot percentage was of the …
From We To Me: Moving Towards An Examination Of Self Identity In An Online, Global, Collaborative, Learning Environment, Danielle P. Espino, Eric Hamilton, Kristina Lux, Seung B. Lee
From We To Me: Moving Towards An Examination Of Self Identity In An Online, Global, Collaborative, Learning Environment, Danielle P. Espino, Eric Hamilton, Kristina Lux, Seung B. Lee
Education Division Scholarship
This paper reflects on previous work using QE to examine patterns of discourse of adolescent learners in a virtual, global, collaborative informal learning setting. The collective impact of involvement in the project on participants’ experiences was observed in various reflective interviews over the last five years. The deep reflection of this work resulted in a research shift from the general impact on the participants to a shift towards examining how such experiences shape self-identity, such as recognizing identity congruence, relational self, and overcoming negative identity fostered by master narrative frameworks. An initial examination of pre-assessment interviews indicates that younger students …
Developing A Point-Of-Care Detection Kit For Parkinson’S Disease Using Gold Nanoparticle-Based Lateral Flow Assay, Ali Aljassabi
Developing A Point-Of-Care Detection Kit For Parkinson’S Disease Using Gold Nanoparticle-Based Lateral Flow Assay, Ali Aljassabi
USF Tampa Graduate Theses and Dissertations
Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease and the fastest-growing neurodegenerative disorder in the world. The major issue with PD is that it takes several years of biological changes until the patient starts to experience physiological symptoms that could affect their daily lives. The major hallmark of PD is the appearance of Lewy body inclusions in the neuron’s cytoplasm, which is rich in a protein called α-Synuclein (α-Syn). Several studies have shown that the levels of α-Syn in blood increase because the excess α-Syn is released from neurons into the bloodstream through extracellular vesicles. …
Research Progress On The Regulation And Mechanism Of Borneol On The Blood-Brain Barrier In Pathological States: A Narrative Review Focused On Ischemic Stroke And Cerebral Glioma, Xinghua Tan, Ke Zhang, Wenyin Shi, Zhihu Tang
Research Progress On The Regulation And Mechanism Of Borneol On The Blood-Brain Barrier In Pathological States: A Narrative Review Focused On Ischemic Stroke And Cerebral Glioma, Xinghua Tan, Ke Zhang, Wenyin Shi, Zhihu Tang
Department of Radiation Oncology Faculty Papers
Background and Objective: The blood-brain barrier (BBB) serves as a dynamic, selective shield, safeguarding the central nervous system (CNS) by separating the brain from circulating blood, preserving its microenvironment, and ensuring stability. However, in the presence of brain pathology, drug delivery across the BBB and blood-tumor barrier (BTB) becomes challenging, hindering effective treatments. Borneol exhibits promise in bidirectionally modulating the BBB under pathological conditions, suggesting at potential clinical applications for related diseases. Our primary goal in this review is to investigate borneol’s potential clinical utility in bidirectionally regulating the BBB under pathological conditions.
Methods: The PubMed database, CNKI (China National …
Marlene Taylor-Ponterotto Interview, Mark Naison
Marlene Taylor-Ponterotto Interview, Mark Naison
Oral Histories
Summary by Eliza Anderson.
Marlene Taylor-Ponterotto is a vital member of both the Fordham and the Bronx communities who has worked diligently to promote racial justice and equity in New York City healthcare and in educational opportunities for marginalized students. Taylor graduated from Fordham College at Rose Hill in 1979 and was the only female student from her class to graduate with a Bachelors of Science in Biology. Taylor now resides in the Riverdale neighborhood of the Bronx and is an active member of the MOSAIC alumni association and a trailblazing advocate for her patients at Heritage Clinic in Central …
Spatial Structure Of Germination And Seed-Associated Fungi In Tropical Pioneer Seeds, Daniela Varon Garcia
Spatial Structure Of Germination And Seed-Associated Fungi In Tropical Pioneer Seeds, Daniela Varon Garcia
USF Tampa Graduate Theses and Dissertations
Negative density-dependent regulation is the process by which host-specific natural enemies reduce the survival of seeds and seedlings of conspecifics near adult trees, favoring heterospecific recruitment, and ultimately increasing local diversity. Negative density-dependent regulation by fungal pathogens has been consistently reported to promote plant diversity in the tropics, even though they tend to be multi-host and host-specificity is rarely reported. Nevertheless, evidence suggests that host-generalist fungi can have host-specific effects that produce disproportionate negative effects on some plant species but not others, promoting regional diversity. However, such studies have not tested for both host-specificity and distance-dependent effects in fully replicated …
Entanglements Of Teenage Food Security Within High School Pantries In Pinellas County, Florida, Karen T. Díaz Serrano
Entanglements Of Teenage Food Security Within High School Pantries In Pinellas County, Florida, Karen T. Díaz Serrano
USF Tampa Graduate Theses and Dissertations
Food insecurity has the ability to shape an individual’s or a family’s everyday life and take emotional, psychological, and physical tolls. Among adolescents, not having access to nutritious food could lead to physical effects during growth and development. Moreover, the stress and anxiety of not knowing where their next meal is coming from and the social stigma associated with being food insecure can have negative effects on mental health. A recent solution to these issues is locating food pantries in high schools. Purpose: This exploratory study examined how high school students in Pinellas County, Florida perceive the use of a …
Substrate Specificity In Abc Transporters Using The E. Coli Methionine Import System, John H. Guardado
Substrate Specificity In Abc Transporters Using The E. Coli Methionine Import System, John H. Guardado
Featured Student Work
ATP-binding cassette (ABC) transporters use the energy of ATP to move substrates across membranes against a concentration gradient. The role of ABC transporters is crucial in several essential cellular functions and mutations in ABC transporters in humans have been linked to several conditions, including cystic fibrosis, liver disease, and diabetes. Despite their central roles in homeostasis, the mechanism of ABC transporters remains poorly understood. Our research is focused on studying an ABC importer in E. coli, as a model system, to examine the mechanism of substrate specificity and transport. The bacterial methionine import system consists of a membrane-embedded transporter, MetNI, …
Respons Inflamasi Pada Kasus Bedah, Yefta Moenadjat
Respons Inflamasi Pada Kasus Bedah, Yefta Moenadjat
Department of Surgery Teaching Materials and Monographs
Buku ini mengulas aspek seluler dan molekuler respons inflamasi pada beberapa kasus bedah, baik akut maupun kronis yang kerap dihadapkan pada masalah di klinik. Beberapa topik diulas antara lain kasus dengan respons inflamasi akut seperti trauma berat, luka bakar, cedera kepala dan respons inflamasi pada pediatrik serta beberapa kasus kronik seperti respons inflamasi pada diabetes mellitus dan lanjut usia
Penyembuhan Luka: Aspek Seluler Dan Biomolekuler, Yefta Moenadjat
Penyembuhan Luka: Aspek Seluler Dan Biomolekuler, Yefta Moenadjat
Department of Surgery Teaching Materials and Monographs
Mengulas aspek seluler dan molekuler penyembuhan luka di setiap fase, dimulai dari hemostasis, inflamasi dan resolusi inflamasi, proliferasi, dan maturasi. Pada bagian terakhir dulas pula gangguan proses penyembuhan luka (luka kronik, non–healing wound) yang kerap dijumpai di klinik.
Identification Of Dual Strn-Ntrk2 Rearrangements In A High Grade Sarcoma, With Good Clinical Response To First-Line Larotrectinib Therapy, Ruihe Lin, Atrayee Basu Mallick, Zi-Xuan Wang, Phd, Scot Andrew Brown, Bo Lu, Md, Wei Jiang
Identification Of Dual Strn-Ntrk2 Rearrangements In A High Grade Sarcoma, With Good Clinical Response To First-Line Larotrectinib Therapy, Ruihe Lin, Atrayee Basu Mallick, Zi-Xuan Wang, Phd, Scot Andrew Brown, Bo Lu, Md, Wei Jiang
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
BACKGROUND: Among the three NTRK genes, NTRK2 possesses a tremendous structural complexity and involves tumorigenesis of several types of tumors. To date, only STRN and RBPMS are identified in the fusion with NTRK2 in adult soft tissue tumors. More recently, the highly selective Trk tyrosine kinases inhibitors, including larotrectinib and entrectinib, have shown significant efficacy for treating tumors harboring NTRK fusions and were approved by FDA.
CASE PRESENTATION: We report a case of sarcoma in a 35-year-old female harboring two STRN-NTRK2 gene fusions, with a good clinical response to first-line larotrectinib treatment. Core biopsy of the 16.5 cm gluteal mass …