Digital Commons Network^™

Targeted Therapy With Nanatinostat And Valganciclovir In Recurrent Ebv-Positive Lymphoid Malignancies: A Phase 1b/2 Study, Bradley Haverkos, Onder Alpdogan, Robert Baiocchi, Jonathan E. Brammer, Tatyana A. Feldman, Marcelo Capra, Elizabeth A. Brem, Santosh Nair, Phillip Scheinberg, Juliana Pereira, Leyla Shune, Erel Joffe, Patricia Young, Susan Spruill, Afton Katkov, Robert Mcrae, Ivor Royston, Douglas V. Faller, Lisa Rojkjaer, Pierluigi Porcu

Department of Medical Oncology Faculty Papers

Lymphomas are not infrequently associated with the Epstein-Barr virus (EBV), and EBV positivity is linked to worse outcomes in several subtypes. Nanatinostat is a class-I selective oral histone deacetylase inhibitor that induces the expression of lytic EBV BGLF4 protein kinase in EBV+ tumor cells, activating ganciclovir via phosphorylation, resulting in tumor cell apoptosis. This phase 1b/2 study investigated the combination of nanatinostat with valganciclovir in patients aged ≥18 years with EBV+ lymphomas relapsed/refractory to ≥1 prior systemic therapy with no viable curative treatment options. In the phase 1b part, 25 patients were enrolled into 5 dose escalation cohorts to determine …

Animal Model Of Angelman Syndrome, Edwin John Weeber, David J. Segal, Henriette O'Geen, Benjamin Pyles, Scott V. Dindot

USF Patents

The present invention concerns non-human animals with cells having a genome that is lacking the entire E3 ubiquitin ligase (Ube3a) gene (including all isoforms and alternative promoters). These animals are useful for modeling Angelman Syndrome. The invention also includes methods for assessing the effect of an agent, such as potential therapeutics, on an animal model by exposing the animal or cells, tissues, or organs isolated therefrom, to an agent of interest.

The Parthenon, October 24, 2023, Evan Green, Conner Woodruff, Matt Schaffer, Chayce Matheny, Victoria Ware, Shauntelle Thompson, Rafael Alfonso, Scott Price

The Parthenon

No abstract provided.

Structural And Functional Characterizations Of The Two Mini-Ferritins In Pseudomonas Aeruginosa Revealed The Coexistence Of A Classic Dps (Pa0962) And A Dps-Like (Pa4880) Protein, Rajapaksha Pathirannahalage Nimesha Hansani Rajapaksha

LSU Doctoral Dissertations

In the P. aeruginosa genome, gene PA0962 codes for a probable DNA-binding protein from starved cells (Pa Dps). Pa Dps is assembled from 12 monomers, each consisting of a four-helix bundle fold typical of Dps proteins. A subunit dimer of Pa Dps harbors two ferroxidase centers. Assembly of a dodecameric structure of Pa Dps is favored by the presence of divalent metal ions and at pH 6.0 in the absence or presence of divalent cations. Pa Dps is unable to form the large DNA-protein complexes typical of many Dps proteins. Instead, Pa Dps acts on plasmid DNA to form relaxed …

Infants Exposed In Utero To Hurricane Maria Have Gut Microbiomes With Reduced Diversity And Altered Metabolic Capacity, Ai Zhang, David De Ángel Solá, Midnela Acevedo Flores, Lijuan Cao, Leran Wang, Josh G Kim, Phillip I Tarr, Barbara B Warner, Nicolás Rosario Matos, Leyao Wang

2020-Current year OA Pubs

The gut microbiome is a potentially important mechanism that links prenatal disaster exposures with increased disease risks. However, whether prenatal disaster exposures are associated with alterations in the infant's gut microbiome remains unknown. We established a birth cohort study named Hurricane as the Origin of Later Alterations in Microbiome (HOLA) after Hurricane Maria struck Puerto Rico in 2017. We enrolled vaginally born Latino term infants aged 2 to 6 months, including

Characterization Of The Autoinhibition Mechanism Of The Heterotrimeric Kinesin-2 Motor Protein Kif3a / Kif3 B, Caleb Ayooluwa Sawe

Theses and Dissertations

Autoinhibition is a conserved mechanism regulating the motor proteins of the kinesin superfamily, which allows active motors to switch into an inactive state after cargo unloading. This regulation is generally believed to be an ATP conservation mechanism. Autoinhibition occurs when the motor molecule assumes a folded conformation in which the non-motor portions interact with, and thereby inhibit the activity of, the motor domains. This process is incompletely characterized in the heterotrimeric kinesin-2 motor (KIF3A/KIF3B), which is essential for mammalian anterograde intraflagellar transport and ciliogenesis. Furthermore, the physiological role that kinesin autoinhibition plays in cellular processes has only recently started to …

Identification Of Chronic Wasting Disease Prions In Decaying Tongue Tissues From Exhumed White-Tailed Deer, Paulina Soto, Francisca Bravo-Risi, Rebeca Benavente, Stuart Lichtenberg, Mitch Lockwood, J Hunter Reed, Rodrigo Morales

Faculty, Staff and Student Publications

Chronic wasting disease (CWD) prions cause fatal neuropathies in farmed and free-ranging cervids. The deposition of prions in natural and humanmade environmental components has been implicated as a major mechanism mediating CWD spread in wild and captive populations. Prions can be deposited in the environment through excreta, tissues, and carcasses from pre-clinical and clinical animals. Furthermore, burial of CWD-positive animals may reduce but not completely mitigate prion spread from carcasses into the surrounding environment. Here, we analyzed exhumed, decaying deer carcasses for the presence of CWD prions. By analyzing tongue tissues through the protein misfolding cyclic amplification (PMCA) technique, we …

Steerable Acoustically Powered Starfish-Inspired Microrobot, Cornel Dillinger, Justin Knipper, Nitesh Nama, Daniel Ahmed

Department of Mechanical and Materials Engineering: Faculty Publications

Soft polymeric microrobots that can be loaded with nanocargoes and driven via external field stimuli can provide innovative solutions in various fields, including precise microscale assembly, targeted therapeutics, microsurgery, and the capture and degradation of unwanted wastewater fragments. However, in aquatic environments, it remains challenging to operate with microrobotic devices due to the predominant viscous resistances and the robots’ limited actuation and sensing capabilities attributed to their miniaturization. The miniature size prevents the incorporation of onboard batteries that can provide sufficient power for propulsion and navigation, necessitating a wireless power supply. Current research examines untethered microrobot manipulation using external magnetic, …

Establishment Of A Birth-To-Education Cohort Of 1 Million Palestinian Refugees Using Electronic Medical Records And Electronic Education Records, Zeina Jamaluddine, Akihiro Seita, Ghada Ballout, Hussam Al-Fudoli, Gloria Paolucci, Shatha Albaik, Rami Ibrahim, Miho Sato, Hala Ghattas Ph.D., Oona M.R. Campbell

Faculty Publications

Introduction

By linking datasets, electronic records can be used to build large birth-cohorts, enabling researchers to cost-effectively answer questions relevant to populations over the life-course. Currently, around 5.8 million Palestinian refugees live in five settings: Jordan, Lebanon, Syria, West Bank, and Gaza Strip. The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides them with free primary health and elementary-school services. It maintains electronic records to do so.

We aimed to establish a birth cohort of Palestinian refugees born between 1st January 2010 and 31st December 2020 living in five settings by linking mother …

Chemical Analysis Of Metabolites From Mangrove Endophytic Fungus, Sefat E Munjerin

USF Tampa Graduate Theses and Dissertations

Natural products hold a significant place in drug discovery for their abundant and unique secondary metabolites. These secondary metabolites which encompass a range of organic compounds such as alkaloids, phenols, peptides, flavonoids, polyketides, and terpenoids, can easily be exploited for drug development. Endophytic fungi, residing harmoniously with its host, have emerged as generous producers of bioactive secondary metabolites, displaying efficacy against a wide array of human pathogens, including the challenging ESKAPE pathogens.

The research explores endophytic fungi and their prospective for drug discovery and development through the synthesis of distinctive secondary metabolites. Endophytic fungus, HM13-26C-2B, collected from Honeymoon Island, Florida …

Uracil-Dna Glycosylase Of Murine Gammaherpesvirus 68 Binds Cognate Viral Replication Factors Independently Of Its Catalytic Residues, Kyle R Smith, Somnath Paul, Qiwen Dong, Orchi Anannya, Darby G Oldenburg, J Craig Forrest, Kevin M Mcbride, Laurie T Krug

Faculty, Staff and Student Publications

Herpesviruses are large double-stranded DNA viruses that encode core replication proteins and accessory factors involved in nucleotide metabolism and DNA repair. Mammalian uracil-DNA glycosylases (UNG) excise deleterious uracil residues from their genomic DNA. Each herpesvirus UNG studied to date has demonstrated conservation of the enzymatic function to excise uracil residues from DNA. We previously reported that a murine gammaherpesvirus (MHV68) with a stop codon in ORF46 (ORF46.stop) that encodes for vUNG was defective in lytic replication and latency in vivo. However, a mutant virus that expressed a catalytically inactive vUNG (ORF46.CM) had no replication defect unless coupled with additional …

Catalase Produced By Candida Albicans Protects Streptococcus Mutans From H2o2 Stress-One More Piece In The Cross-Kingdom Synergism Puzzle, Callahan Katrak, Bruna A Garcia, Louise M Dornelas-Figueira, Mary Nguyen, Robert B Williams, Michael C Lorenz, Jacqueline Abranches

Faculty, Staff and Student Publications

Co-infection with Streptococcus mutans and Candida albicans is associated with dental caries, and their co-cultivation results in enhanced biofilm matrix production that contributes to increased virulence and caries risk. Moreover, the catalase-negative S. mutans demonstrates increased oxidative stress tolerance when co-cultivated in biofilms with C. albicans, a catalase-producing yeast. Here, we sought to obtain mechanistic insights into the increased H2O2 tolerance of S. mutans when co-cultivated with clinical isolates of Candida glabrata, Candida tropicalis, and C. albicans. Additionally, the C. albicans SC5314 laboratory strain, its catalase mutant (SC5314Δcat1), and S. mutans UA159 and its glucosyltransferase B/C …

Changes In Rna Expression Of Hut78 Cells Resulting From The Hiv-1 Viral Protein R R77q Mutation, Joshua S. Ramsey

Theses and Dissertations

Human immunodeficiency virus type 1 (HIV-1) is the causative virus for acquired immunodeficiency syndrome (AIDS). AIDS is characterized by chronic inflammation and reduction of CD4+ T-cells in the blood. This leads to the patient becoming immunocompromised and much more susceptible to disease in general. Different phenotypes in the progression of AIDS have been observed in patients in either progressing to AIDS faster as a Rapid Progressor (RP), or slower as a Long-Term Non-Progressor (LTNP). Researching elements that result in the LTNP phenotype is of interest as it has the potential to offer alternative treatments and therapies to those suffering from …

Volatile Profiling Distinguishes Streptococcus Pyogenes From Other Respiratory Streptococcal Species, Amalia Z Berna, Joseph A Merriman, Leah Mellett, Danealle K Parchment, Michael G Caparon, Audrey R Odom John

2020-Current year OA Pubs

Sore throat is one of the most common complaints encountered in the ambulatory clinical setting. Rapid, culture-independent diagnostic techniques that do not rely on pharyngeal swabs would be highly valuable as a point-of-care strategy to guide outpatient antibiotic treatment. Despite the promise of this approach, efforts to detect volatiles during oropharyngeal infection have yet been limited. In our research study, we sought to evaluate for specific bacterial volatile organic compounds (VOC) biomarkers in isolated cultures

Covid-19 And Respiratory Failure: A Retrospective Observational Study From A Rural Midwest Hospital, Alex Kneller, Cyril Abadir, Osaheni Amadasu, Matias Matias, Robert Arnce, Nova Beyersdorfer, Dennis Wolff, Greg Stahl, Kerry Johnson, Scott Goade

Faculty and Staff Publications

Background

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces the coronavirus disease of 2019 (COVID-19), primarily presenting with respiratory symptoms, including cough, shortness of breath, etc. Respiratory failure can present similarly to a COVID-19 infection, and COVID-19 infection can cause respiratory failure. Thus, it is important to study respiratory failure, COVID-19, and the interaction between the two in hopes of improving patient outcomes. In this study, we compared mortality rates in patients admitted with COVID-19, respiratory failure, or both. Mortality rates in our study populations were further scrutinized based on patient age.

Materials and methods

Respiratory failure and …

Population-Level Dna Study Of Stenotrema And Euchemotrema (Gastropoda: Polygyridae: Stenotrematini) Reveals Majority Of Species Are Poorly Circumscribed, Alexander C. Cooper, Elizabeth A. Bergey, Kathryn E. Perez

School of Integrative Biological & Chemical Sciences Faculty Publications

The North American land snail tribe Stenotrematini (Emberton, 1995) is composed of 40 taxa from the genera Stenotrema (Rafinesque, 1819) and Euchemotrema (Archer, 1939). We conducted the first thorough examination of this group since 1948 by sequencing 196 individuals representing 31 of 40 members of the tribe using a combination of cytochrome c oxidase subunit I (COI) and a portion of the 5.8S gene of the large ribosomal subunit (LSU) with the accompanying internal transcribed spacer (ITS-2) region. We reexamined the validity of this tribe by incorporating new sequences with previous DNA work on the …

Enterprise Architecture In Healthcare Networks: A Systematic Literature Review, Arjen Maris, Stijn Hoppenbrouwers, Jos Van Hillegersberg

Communications of the IIMA

Healthcare organizations collaborate, share knowledge, and need to be accountable to each other. Therefore, healthcare organizations manage a dynamic information system landscape. Enterprise Architecture (EA) is a management tool for aligning these landscapes to the primary information needs that healthcare organizations have. EA is of value in some environments, but it seems to be not well suited to the dynamics of healthcare. Despite the publication of several systematic literature reviews on EA in healthcare, a systematic literature study comparing EA applicability at various levels of cooperation (intra, inter, and network collaboration) is lacking. Therefore, we posed the following research question: …

(Keynote) Open Together: Uniting Our Community To Build A Better Future, Molly Keener

All Things Open

The keynote presentation of KSU's Open Access Week 2023.

An Analysis Of Communication For Foster Parents: Interpersonal, Small Group, And Public Speaking Skills Necessary For Foster Parenting, Kaitlyn Randall

Communication and Theater Association of Minnesota Journal

Communication is a core aspect of what foster parents do every day. However, communication research focusing on foster parents is limited. Foster parents should understand interpersonal communication, small group communication, and public speaking. Understanding the basic principles of these communication disciplines will help foster parents succeed in their role. Interpersonal communication creates relationships between the foster parent and child through inclusion, control, and affection. Small group communication aspects of group roles, meeting facilitation, and conflict management are used in interactions with caseworkers. The public speaking skills of preparation and practice are used during court proceedings, orientations, and support groups. Providing …

Volume 46, 2023 Communication And Theater Association Of Minnesota Journal

Communication and Theater Association of Minnesota Journal

Complete digitized volume (volume 46) of Communication and Theater Association of Minnesota Journal.

Flexner Report 3.0—Structurally Competent Healthcare, James Peter Meza

Clinical Research in Practice: The Journal of Team Hippocrates

The editor advocates to formalize the addition of “Medical Social Sciences” as a basic science in our Schools of Medicine and “Clinical Decision Science” as the corollary clinical practice discipline: a “Flexner Report 3.0."

Harris Hawks Feature Selection In Distributed Machine Learning For Secure Iot Environments, Neveen Hijazi, Moayad Aloqaily, Bassem Ouni, Fakhri Karray, Merouane Debbah

Machine Learning Faculty Publications

The development of the Internet of Things (IoT) has dramatically expanded our daily lives, playing a pivotal role in the enablement of smart cities, healthcare, and buildings. Emerging technologies, such as IoT, seek to improve the quality of service in cognitive cities. Although IoT applications are helpful in smart building applications, they present a real risk as the large number of interconnected devices in those buildings, using heterogeneous networks, increases the number of potential IoT attacks. IoT applications can collect and transfer sensitive data. Therefore, it is necessary to develop new methods to detect hacked IoT devices. This paper proposes …

2023.10.23 - Academic/Student Affairs, Enrollment, And Technology Committee Meeting Minutes, Northeastern Illinois University Board Of Trustees

Board of Trustees - 2023

Meeting materials for the NEIU Academic/Student Affairs, Enrollment, and Technology Committee

The Utah Statesman, October 23, 2023, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Essential Role Of The Amino-Terminal Region Of Drosha For The Microprocessor Function, Amit Prabhakar, Song Hu, Jin Tang, Prajakta Ghatpande, Giorgio Lagna, Xuan Jiang, Akiko Hata

Biology

Drosha is a core component of the Microprocessor complex that cleaves primary-microRNAs (pri-miRNAs) to generate precursor-miRNA and regulates the expression of ∼80 ribosomal protein (RP) genes. Despite the fact that mutations in the amino-terminal region of Drosha (Drosha-NTR) are associated with a vascular disorder, hereditary hemorrhagic telangiectasia, the precise function of Drosha-NTR remains unclear. By deleting exon 5 from the Drosha gene and generating a Drosha mutant lacking the NTR (ΔN), we demonstrate that ΔN is unable to process pri-miRNAs, which leads to a global miRNA depletion, except for the miR-183/96/182 cluster. We find that Argonaute 2 facilitates the processing …

Quantitative Analyses Of T Cell Motion In Tissue Reveals Factors Driving T Cell Search In Tissues, David J. Torres, Paulus Mrass, Janie Byrum, Arrick Gonzales, Dominick N. Martinez, Evelyn Juarez, Emily Thompson, Vaiva Vezys, Melanie E. Moses, Judy L. Cannon

Pathology Research and Scholarship

T cells are required to clear infection, and T cell motion plays a role in how quickly a T cell finds its target, from initial naive T cell activation by a dendritic cell to interaction with target cells in infected tissue. To better understand how different tissue environments affect T cell motility, we compared multiple features of T cell motion including speed, persistence, turning angle, directionality, and confinement of T cells moving in multiple murine tissues using microscopy. We quantitatively analyzed naive T cell motility within the lymph node and compared motility parameters with activated CD8 T cells moving within …

Intouch Week Of October 23, 2023, New York Medical College

InTouch

• Founder's Dinner 2023
• NYMC Celebrates Opening of Newly Renovated BSB Laboratories
• D.P.T. Students Set New Fundraising Record at 25^th Annual Race for Rehab
• Chancellor Halperin Hosts Town Hall Meeting
• NYMC Pets The Stress Away
• TU Hosts AI Literacy: Library’s Perspective Webinar
• Center for Long-Term Care Hosted Estate Planning 101 Webinar
• NYMC Research | Drs. Marina K. Holz and Julie S. Di Martino
• NYMC Unites to Save Lives

Genomic Insights Into The Mystery Of Mouse Mummies On The Summits Of Atacama Volcanoes, Jay F. Storz, Schuyler Liphardt, Marcial Quiroga-Carmona, Naim M. Bautista, Juan C. Opazo, Guillermo D’Elía, Jeffrey M. Good

Jay F. Storz Publications

Our understanding of the limits of animal life is continually revised by scientific exploration of extreme environments. Here we report the discovery of mummified cadavers of leaf-eared mice, Phyllotis vaccarum, from the summits of three different Andean volcanoes at elevations 6,029–6,233 m above sea level in the Puna de Atacama in Chile and Argentina. Such extreme elevations were previously assumed to be completely uninhabitable by mammals. In combination with a live-captured specimen of the same species from the nearby summit of Volcán Llullaillaco (6,739 m),¹ the summit mummies represent the highest altitude physical records of mammals in the …

The High Pressure Dependence Of X-Ray Induced Decomposition Of Cadmium Oxalate, Adrian F. Lua Sanchez, Petrika Cifligu, Marc Graff, Michael Pravica, Pradip K. Bhowmik, Changyong Park, Egor Evlyukhin

Physics & Astronomy Faculty Research

The high proclivity of x rays to destabilize and distort molecular structures has been previously utilized in the synthesis of novel compounds. Here, we show that x-ray induced decomposition of cadmium oxalate induces chemical and structural transformations only at 0.5 and 1 GPa. Using x-ray diffraction and Raman spectroscopy, the synthesized product is identified as cadmium carbonate with cadmium oxalate remnants, which is stable under ambient conditions. At ambient and >1 GPa pressures, only degradation of the electronic density distribution is observed. The transformation kinetics are examined in terms of Avrami’s model, which demonstrates that despite the necessity of high …

Molecular Mechanisms Underlying Host Immunity In The Drosophila-Parasitoid System And Its Application In A Course-Based Research Experience, Ashley Waring-Sparks

Theses and Dissertations

A functional immune response is essential for the survival of all living organisms. The fruit fly Drosophila melanogaster is a well-established model for studying host immunity as well as metabolic regulation during an immune response. Fruit fly larvae, in nature, are commonly infected by parasitoid wasps whose survival is dependent on the successful parasitization of their host. The immune response that the fly elicits toward the wasp egg is a primitive yet effective process. I characterized the genes induced by a host during infection, identified metabolites present in a host during infection, investigated the role of Ab in the cellular …