Digital Commons Network^™

Using Pavlovian Sign-Tracking To Increase Self-Control In Rats, Saba Mahmoudi

All Graduate Theses and Dissertations, Fall 2023 to Present

Impulsivity is correlated with various maladaptive behaviors (e.g., gambling and substance-used disorders), therefore many studies have been designed to find methods to reduce impulsive choice. Although these procedures (e.g., delay fading and delay-exposure training) are effective, they involve extended training durations. One method that has not yet been explored in promoting self-control is Pavlovian conditioning. During Pavlovian conditioning, a localized conditioned stimulus (CS) that signals an imminent food delivery can (a) evoke sign-tracking behavior (i.e., attraction to, and physically interacting with the CS) and (b) function as a conditioned reinforcer (i.e., the subject will work to access the CS). This …

The Caboose By A Longshot: Impact Of Large Age Gaps On Youngest Siblings, Kelly Clark Young

All Graduate Theses and Dissertations, Fall 2023 to Present

Siblings play a large role in developmental experiences and views of oneself. However, most research addressing siblings looks at individuals who grow up close in age with their siblings. What is currently known about sibling relationships does not seem to fit for those who have siblings but are not close in age to them, referred to in this study as a sibling age gap.

To learn more about what it was like to grow up with siblings who are much older, I interviewed 11 individuals who were the youngest siblings in their family and five or more years younger than …

Specialized Recreation, Spatial Behavior, And Ecological Implications In The Nature Reserve Of Orange County, Ca, Jake Van Deursen

All Graduate Theses and Dissertations, Fall 2023 to Present

A widespread surge in park and protected area (PPA) visitation strikes managers with the imminent challenge of preserving ecological conditions and maintaining accessibility in the open spaces that are a fundamental component to the health and wellness needs of society. In the field of recreation resource management, recreation specialization, the selective channeling of interests and abilities into a specific recreational activity, has contributed to comprehensive understandings of recreation behavior, site preference, management perceptions and conservation support. Contributing to historical understandings of specialization can inform recreation planning on the diversity of uses occurring in urban-proximate PPAs. Survey data providing information on …

Processes Of Couple Co-Regulation In Bereavement: A Longitudinal Study, Jessica Barboza

All Graduate Theses and Dissertations, Fall 2023 to Present

Five couples reported on their experience of coping with and supporting their partner through the loss of a child. In-depth interviews with these bereaved parents revealed that couples engage in processes of regulating self, regulating other and forming a grief rhythm after child-loss. These processes have important implications for future research and therapeutic practice with bereaved parents, couples, and families.

Metapopulation Genomics Of American Goshawks In The Intermountain West, Megan M. Sidran

All Graduate Theses and Dissertations, Fall 2023 to Present

Understanding a species dispersal ecology and population dynamics is essential to effectively manage and conserve a species. As advancing technology improves our knowledge of species movements, it is becoming clear that many species form metapopulations to some extent. A metapopulation is a network of interconnected subpopulations that exchange reproductive individuals with subpopulations occupying nearby patches. Metapopulations have been observed in a variety of species, ranging from plants to vertebrates, and can vary greatly in their dynamics (level of connectivity and gene flow) based on the species behavior and life history strategy.

Forming a metapopulation can add much resilience to the …

Movement Patterns Of A Federally Endangered Minnow In A Fragmented Desert River, Martinique J. Chavez

All Graduate Theses and Dissertations, Fall 2023 to Present

Fishes are unified in their need to move within the systems they occupy, and their movement patterns can be fundamental to their ecology and survival. Many large rivers in North America are fragmented by dams that modify natural flow regimes, compromise connectivity, and imperil freshwater fishes dependent on unrestricted movement in order to complete their life history. Coincident with widespread river fragmentation, are the declines of numerous endemic desert fishes in the American southwest. The Rio Grande Silvery Minnow (Hybognathus amarus, RGSM), has experienced a 95% reduction in its historical range and is now restricted to a highly …

Investigating Parents' Value Of Children Learning About Agriculture, Amelia J. Miller

All Graduate Theses and Dissertations, Fall 2023 to Present

It is commonly held that parents have a profound impact on child development. Decades of research investigated the ways parents, the community, and school staff interact to foster student learning during kindergarten through twelfth grade education. Agriculture provides for daily needs through the growth, harvest, and processing of food, fiber, fuel, and forestry products. This research sought to understand the level of importance parents place on their children learning about agriculture in school.

A 26-question survey was distributed to a nationally representative sample of parents having at least one child in K-12 education within the United States. Results of this …

Furthering Indaziflam-Based Management Strategies Of Three Invasive Annual Grasses In Northern Utah, Peter Weston Maughan

All Graduate Theses and Dissertations, Fall 2023 to Present

Indaziflam is an herbicide highly recognized for its potential to effectively control weedy, winter germinating grasses, such as downy brome, as the herbicides prevents seed germination for several years. Unfortunately, most of these studies only capture the first 2-3 years of indaziflam’s 3-5 years soil activity. This thesis sought to better understand indaziflam’s long-term effects by monitoring both a healthy ecosystem and a degraded ecosystem for up to 5 years after indaziflam application. A secondary study was also conducted to better understand the potential of revegetation via reseeding in indaziflam treated soils. The study concluded that indaziflam very little long-term …

The Mojave Poppy Bee (Perdita Meconis) And A Primary Plant Host, The Las Vegas Bear Poppy (Arctomecon Californica): Status And Interactions, Sarit Chanprame

All Graduate Theses and Dissertations, Fall 2023 to Present

The Mojave Desert is one of the most biodiverse places in North America. A harsh environment with many species results in complex relationships between animals and plants. This study focuses on one bee-plant relationship, the Mojave poppy bee, and the Las Vegas Bear Poppy.

The Mojave poppy bee is rare and has only been collected from Las Vegas Bear Poppy, Dwarf Bear Poppy, and a few species of prickly poppies. A 1995 report suggested the bee was a major contributor of pollination for the Las Vegas Bear Poppy in Clark County, Nevada. More recently (2019), their local extinction in southwestern …

Developing Empirical Predictive Models To Support Conservation Planning For Threatened Frogs, Toads, And Turtles In South-Coastal California, Umarfarooq Adavudi Abdulwahab

All Graduate Theses and Dissertations, Fall 2023 to Present

Amphibians and reptiles (i.e., herptiles) are among the most threatened groups of species on Earth. The major threats to these species include the direct, indirect, and synergistic effects of habitat loss and fragmentation, invasive species, disease, overexploitation, and pollution. To protect and restore species, natural resource managers need effective, data-driven conservation plans that are grounded in sound knowledge of species distributions and habitat requirements. Species distribution models (SDMs) are popular tools used to assess species-habitat relationships. However, SDMs are sensitive to the choice and quality of input data, both of which can affect model accuracy and precision and lead to …

Ecology And Management Of Dyer's Woad (Isatis Tinctoria) In Northern Utah, Erin Marie Hettinger

All Graduate Theses and Dissertations, Fall 2023 to Present

Dyer’s woad (Isatis tinctoria L.) is a non-native forb that continues to threaten natural areas throughout Northern Utah and much of the Intermountain West. Once introduced, dyer’s woad can become extremely invasive, decreasing forage quality, and displacing native species. While dyer’s woad is found throughout much of Northern Utah, its range in other states remains limited. If promptly managed, control success in these areas will be much higher and populations may be kept at bay before ecological damage becomes severe.

This project tested the ability of dyer’s woad seedlings to compete with common rangeland grasslands at varied densities as …

Whole-Genome Sequencing Uncovers Two Loci For Coronary Artery Calcification And Identifies Arse As A Regulator Of Vascular Calcification, Paul S De Vries, Matthew P Conomos, Kuldeep Singh, Christopher J Nicholson, Deepti Jain, Natalie R Hasbani, Wanlin Jiang, Sujin Lee, Christian L Lino Cardenas, Sharon M Lutz, Doris Wong, Xiuqing Guo, Jie Yao, Erica P Young, Catherine Tcheandjieu, Austin T Hilliard, Joshua C Bis, Lawrence F Bielak, Michael R Brown, Shaila Musharoff, Shoa L Clarke, James G Terry, Nicholette D Palmer, Lisa R Yanek, Huichun Xu, Nancy Heard-Costa, Jennifer Wessel, Margaret Sunitha Selvaraj, Rebecca H Li, Xiao Sun, Adam W Turner, Adrienne M Stilp, Alyna Khan, Anne B Newman, Asif Rasheed, Barry I Freedman, Brian G Kral, Caitlin P Mchugh, Chani Hodonsky, Danish Saleheen, David M Herrington, David R Jacobs, Deborah A Nickerson, Eric Boerwinkle, Fei Fei Wang, Gerardo Heiss, Goo Jun, Greg L Kinney, Haakon H Sigurslid, Harshavardhan Doddapaneni, Ira M Hall, Isabela M Bensenor, Jai Broome, James D Crapo, James G Wilson, Jennifer A Smith, John Blangero, Jose D Vargas, Jose Verdezoto Mosquera, Joshua D Smith, Karine A Viaud-Martinez, Kathleen A Ryan, Kendra A Young, Kent D Taylor, Leslie A Lange, Leslie S Emery, Marcio S Bittencourt, Matthew J Budoff, May E Montasser, Miao Yu, Michael C Mahaney, Mohammed S Mahamdeh, Myriam Fornage, Nora Franceschini, Paulo A Lotufo, Pradeep Natarajan, Quenna Wong, Rasika A Mathias, Richard A Gibbs, Ron Do, Roxana Mehran, Russell P Tracy, Ryan W Kim, Sarah C Nelson, Scott M Damrauer, Sharon L R Kardia, Stephen S Rich, Valentin Fuster, Valerio Napolioni, Wei Zhao, Wenjie Tian, Xianyong Yin, Yuan-I Min, Alisa K Manning, Gina Peloso, Tanika N Kelly, Christopher J O'Donnell, Alanna C Morrison, Joanne E Curran, Warren M Zapol, Donald W Bowden, Lewis C Becker, Adolfo Correa, Braxton D Mitchell, Bruce M Psaty, John Jeffrey Carr, Alexandre C Pereira, Themistocles L Assimes, Nathan O Stitziel, John E Hokanson, Cecelia A Laurie, Jerome I Rotter, Ramachandran S Vasan, Wendy S Post, Patricia A Peyser, Clint L Miller, Rajeev Malhotra

Faculty, Staff and Student Publications

Coronary artery calcification (CAC) is a measure of atherosclerosis and a well-established predictor of coronary artery disease (CAD) events. Here we describe a genome-wide association study (GWAS) of CAC in 22,400 participants from multiple ancestral groups. We confirmed associations with four known loci and identified two additional loci associated with CAC (ARSE and MMP16), with evidence of significant associations in replication analyses for both novel loci. Functional assays of ARSE and MMP16 in human vascular smooth muscle cells (VSMCs) demonstrate that ARSE is a promoter of VSMC calcification and VSMC phenotype switching from a contractile to a calcifying …

Type 2 Diabetes Modifies The Association Of Cad Genomic Risk Variants With Subclinical Atherosclerosis, Natalie R Hasbani, Kenneth E Westerman, Soo Heon Kwak, Han Chen, Xihao Li, Daniel Di Corpo, Jennifer Wessel, Joshua C Bis, Chloè Sarnowski, Peitao Wu, Lawrence F Bielak, Xiuqing Guo, Nancy Heard-Costa, Gregory L Kinney, Michael C Mahaney, May E Montasser, Nicholette D Palmer, Laura M Raffield, James G Terry, Lisa R Yanek, Jessica Bon, Donald W Bowden, Jennifer A Brody, Ravindranath Duggirala, David R Jacobs, Rita R Kalyani, Leslie A Lange, Braxton D Mitchell, Jennifer A Smith, Kent D Taylor, April P Carson, Joanne E Curran, Myriam Fornage, Barry I Freedman, Stacey Gabriel, Richard A Gibbs, Namrata Gupta, Sharon L R Kardia, Brian G Kral, Zeineen Momin, Anne B Newman, Wendy S Post, Karine A Viaud-Martinez, Kendra A Young, Lewis C Becker, Alain G Bertoni, John Blangero, John J Carr, Katherine Pratte, Bruce M Psaty, Stephen S Rich, Joseph C Wu, Rajeev Malhotra, Patricia A Peyser, Alanna C Morrison, Ramachandran S Vasan, Xihong Lin, Jerome I Rotter, James B Meigs, Alisa K Manning, Paul S De Vries

Faculty, Staff and Student Publications

BACKGROUND: Individuals with type 2 diabetes (T2D) have an increased risk of coronary artery disease (CAD), but questions remain about the underlying pathology. Identifying which CAD loci are modified by T2D in the development of subclinical atherosclerosis (coronary artery calcification [CAC], carotid intima-media thickness, or carotid plaque) may improve our understanding of the mechanisms leading to the increased CAD in T2D.

METHODS: We compared the common and rare variant associations of known CAD loci from the literature on CAC, carotid intima-media thickness, and carotid plaque in up to 29 670 participants, including up to 24 157 normoglycemic controls and 5513 …

The Intersectional Experiences Of Young And Educated Latine Men's Masculinity: An Exploration Of Gender, Race, Ethnicity, Skin Tone, Sexual Orientation, And Region Of Origin, Juan Estrada

All Graduate Theses and Dissertations, Fall 2023 to Present

Latine masculinity is often looked at through simplistic concepts like machismo or caballerismo, which fail to fully consider the different aspects of Latine men’s identities. For example, how might a cisgender, gay, dark skinned, Latine man understand his masculinity as he moves between Latine and United Statesian cultures. In this study, we wanted to do two things: first, we wanted to understand how the cultural and intersectional aspects of their lives shape how Latine men see their masculinity. Second, we wanted to celebrate the diverse ways in which they express their masculinity, considering things like their skin color, region …

Surface Water Hydrology Within The Great Salt Lake Basin, Madeline F. Merck

All Graduate Theses and Dissertations, Fall 2023 to Present

The Great Salt Lake (GSL) and its tributaries are ecologically and economically important resources for Utah. It is a highly saline lake, with salinity that is several times saltier than the ocean. Lake uses are heavily influenced by its salinity and lake level and, similarly, river uses by its streamflow quantity. Currently, the GSL Basin is experiencing changes that affect tributary inflows, lake level, and salinity. For my dissertation and in support of better lake management, I addressed important gaps in our understanding of the lake and the changes it is undergoing.

Chapter 2 is an examination of the distribution …

Dusky Grouse Population Ecology And Thermal Landscape Ecology In The Great Basin Ecosystem, Stephanie M. Landry

All Graduate Theses and Dissertations, Fall 2023 to Present

Dusky Grouse are a mountainous forest grouse found throughout the western, inland mountain ranges of the United States and Canada. While a few studies have looked at Dusky Grouse in the Rocky Mountain Ecosystem of their range, there have been no prior studies of the Dusky Grouse in the Great Basin Ecosystem aside from a brief survey by Zwickel and Bendell in 2004 in the Duck Creek Range of Nevada. With the available habitats differing in both species diversity and availability on the landscape between the two Ecosystems, I wanted to assess characteristics about the Dusky Grouse populations at the …

Effects Of Indole Derivative Idc16 On Cell Proliferation, Transfection, And Alternative Splicing In Production Of Lentiviral Vectors By Transient Co-Transfection, Nataly Mier

All Graduate Theses and Dissertations, Fall 2023 to Present

Viruses can efficiently introduce genetic material into a variety of cells through cell infection. Therefore, viral vectors, defined as virus-based gene delivery systems, effectively transfer functional gene constructs to target cells. Among different viral vectors, lentiviral vectors are of interest due to the advantages offered to research and therapeutic applications. Low productivity of lentiviral vectors in mammalian producer cells and high production cost, however, remain barriers to the vectors’ routinary use, particularly in clinical settings.

Since most lentiviral vectors are derived from human immunodeficiency virus type I, their genome has been engineered to increase safety. Nevertheless, modifications of the lentiviral …

Relative Hepatotoxocity, Carcinogenicity, And Toxicogenomics Of Select Dehydropyrrolizidine Alkaloids In Mice, Michael J. Clayton

All Graduate Theses and Dissertations, Fall 2023 to Present

Dehydropyrrolizidine alkaloids are arguably the most important plant derived toxins in terms of impact on human and animal health. Dehydropyrrolizidine alkaloids are a large group of chemically related compounds found in 3% of flowering plants worldwide. Human exposure occurs from ingestion of herbal products including teas supplements or contaminated grain. Animals are exposed through contaminated feed or grazing. There are at least 350 identified toxic PAs, from more than 6,000 plants. The toxins primarily cause liver damage, but some are proven to cause cancer. Indidvidual dehydropyrrolizidine alkaloids vary in their toxic effects. Riddelliine is the only dehydropyrrolizidine alkaloid with extensive …

Restoration Strategies For Wetlands In The Arid West: Seeding And Planting Approaches For Lakeshore Ecosystems, Jes Braun

All Graduate Theses and Dissertations, Fall 2023 to Present

Wetlands are widely recognized for their valuable benefits such as providing habitat, improving water quality, and reducing the impacts of flooding. However, wetlands face threats from development, drought, and invasive species. This is particularly apparent in the arid west, where upstream water use and drought make water scarcer and contribute to dramatically changing water levels. Here, I investigated revegetation techniques for lakeshore wetlands, using Utah Lake as a case study. Although recent management efforts have minimized invasive Phragmites cover, the desired plant communities are not returning as quickly as needed, highlighting the need to research restoration techniques. Through my research, …

Exploring Social Hierarchy Computationally To Further Our Understanding Of Social Organizations Within Their Environments, Stanley L. Rhodes Jr.

All Graduate Theses and Dissertations, Fall 2023 to Present

Hierarchy is ever-present across countless human societies, a seemingly inescapable reality of small organizations and national governments. However, there is a lot about hierarchy we don’t understand, and if we want to make better organizations and better society, it is crucial we learn more about it. This dissertation investigates three questions: 1) “What is hierarchy?” 2) “How is hierarchy useful?” 3) “How does hierarchy vary?” I find that social scientists do not all mean the same thing by hierarchy, even within the same fields; yet, they do consistently write of hierarchy as control (like boss-employee relations), hierarchy as rank (like …

Comparing Scaling Approaches To Estimate Unimpaired Streamflow Timeseries And Seasonal Flow Metrics At Ungauged Streams, Karl Christensen

All Graduate Theses and Dissertations, Fall 2023 to Present

River ecosystems are controlled in part by natural variation in the flow regime and streamflow alterations that impair these natural variations often have negative impacts for aquatic species. Flow metrics describing attributes of the natural flow regime can inform environmental water management goals to maintain and restore river ecosystems by mirroring critical aspects of the natural flow regime. However, unimpaired daily streamflow data needed to calculate these flow metrics is not always readily available. Statistical scaling approaches present an opportunity to estimate unimpaired flow metrics at ungauged locations to better address environmental water management objectives. This study evaluates a suite …

The Impacts Of Maturation And Experience On Volumetric Neuroplasticity In Solitary And Social Bees, Mallory A. Hagadorn

All Graduate Theses and Dissertations, Fall 2023 to Present

Some animals are incredibly social, living and working together as one cohesive group. Alternatively, many animals are solitary, never living with and rarely interacting with others. A large body of biological research has focused on understanding the role that brains play in promoting these behavioral differences across species. Even so, it remains unclear why some brains facilitate social behavior while others do not. My dissertation aims to advance our understanding of this concept by characterizing bees’ brains and how they change over a lifetime. Bees are beneficial for investigating relationships between the brain and social behavior because some species are …

Phenology Of The Invasive Balsam Woolly Adelgid, Adelges Piceae (Ratz.) (Hemiptera: Adelgidae), On Subalpine Fir In Northern Utah, Elizabeth L. Rideout

All Graduate Theses and Dissertations, Fall 2023 to Present

Balsam woolly adelgid (BWA) is an invasive true fir pest in North America. Native to Europe, BWA was first discovered in Utah attacking subalpine fir in 2017. Recent BWA-caused subalpine fir mortality in northern Utah has prompted the need for baseline biological research to support pest management. Small-bodied and blending easily with its environment, BWA is a challenging pest to detect and study. Phenology, or the timing and characteristics of life stages through the year, of BWA varies depending on elevation and climate and is unstudied in Utah. This research focuses on defining aspects of BWA’s phenology, including the number …

Understanding The Effects Of A Mobile Flow Visualization Learning Tool On Engineering Undergraduate Interest In Fluid Mechanics, Lori M. Openshaw

All Graduate Theses and Dissertations, Fall 2023 to Present

Fluid mechanics is a difficult engineering course that tends to act as a weed-out course for undergraduate students. Despite this, fluid mechanics is critical, with related careers in disciplines such as Mechanical, Aerospace, Civil, Environmental, Biological, Ocean, and Naval engineering. Within these fields, there is a lack of graduates with sufficient fluid mechanics knowledge to fill the available positions. One solution to this career pipeline is to increase student interest and understanding of fluid mechanics.

Efforts to make fluid mechanics more interesting and easily understood include curricular changes such as emphasizing historical aspects of fluids, computer simulations that model complex …

Birth Defects In Offspring Of Adolescent And Young Adults With A History Of Cancer: A Population-Based Study Of 27,000 Women, Caitlin C Murphy, Andrea C Betts, Sandi L Pruitt, Barbara A Cohn, L Aubree Shay, Marlyn A Allicock, Jennifer S Wang, Philip J Lupo

Faculty, Staff and Students Publications

BACKGROUND: We examined birth defects in offspring of adolescent and young adult (AYA) women with a history of cancer (age 15-39 years at diagnosis).

METHODS: We identified AYA women diagnosed with cancer between January 1, 1999, and December 31, 2015 using population-based data from the Texas Cancer Registry; data were linked with live birth and fetal death certificates through December 31, 2016 to identify singleton births to AYA women after diagnosis. Birth defects in offspring through age 12 months were ascertained from the Texas Birth Defects Registry. We estimated risk of birth defects in offspring of AYA women and women …

Targeted Gene Expression Profiling Predicts Meningioma Outcomes And Radiotherapy Responses, William C Chen, Abrar Choudhury, Mark W Youngblood, Mei-Yin C Polley, Calixto-Hope G Lucas, Kanish Mirchia, Sybren L N Maas, Abigail K Suwala, Minhee Won, James C Bayley, Akdes S Harmanci, Arif O Harmanci, Tiemo J Klisch, Minh P Nguyen, Harish N Vasudevan, Kathleen Mccortney, Theresa J Yu, Varun Bhave, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Jason W Chan, Haley K Perlow, Joshua D Palmer, Christine Haberler, Anna S Berghoff, Matthias Preusser, Theodore P Nicolaides, Christian Mawrin, Sameer Agnihotri, Adam Resnick, Brian R Rood, Jessica Chew, Jacob S Young, Lauren Boreta, Steve E Braunstein, Jessica Schulte, Nicholas Butowski, Sandro Santagata, David Spetzler, Nancy Ann Oberheim Bush, Javier E Villanueva-Meyer, James P Chandler, David A Solomon, C Leland Rogers, Stephanie L Pugh, Minesh P Mehta, Penny K Sneed, Mitchel S Berger, Craig M Horbinski, Michael W Mcdermott, Arie Perry, Wenya Linda Bi, Akash J Patel, Felix Sahm, Stephen T Magill, David R Raleigh

Faculty, Staff and Student Publications

Surgery is the mainstay of treatment for meningioma, the most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and indications for postoperative radiotherapy are controversial. Here we develop a targeted gene expression biomarker that predicts meningioma outcomes and radiotherapy responses. Using a discovery cohort of 173 meningiomas, we developed a 34-gene expression risk score and performed clinical and analytical validation of this biomarker on independent meningiomas from 12 institutions across 3 continents (N = 1,856), including 103 meningiomas from a prospective clinical trial. The gene expression biomarker improved discrimination of outcomes compared with all other systems …

Modulating A Prebiotic Food Source Influences Inflammation And Immune-Regulating Gut Microbes And Metabolites: Insights From The Be Gone Trial, Xiaotao Zhang, Ehsan Irajizad, Kristi L Hoffman, Johannes F Fahrmann, Fangyu Li, Yongwoo David Seo, Gladys J Browman, Jennifer B Dennison, Jody Vykoukal, Pamela N Luna, Wesley Siu, Ranran Wu, Eunice Murage, Nadim J Ajami, Jennifer L Mcquade, Jennifer A Wargo, James P Long, Kim-Anh Do, Johanna W Lampe, Karen M Basen-Engquist, Pablo C Okhuysen, Scott Kopetz, Samir M Hanash, Joseph F Petrosino, Paul Scheet, Carrie R Daniel

Faculty, Staff and Student Publications

BACKGROUND: Accessible prebiotic foods hold strong potential to jointly target gut health and metabolic health in high-risk patients. The BE GONE trial targeted the gut microbiota of obese surveillance patients with a history of colorectal neoplasia through a straightforward bean intervention.

METHODS: This low-risk, non-invasive dietary intervention trial was conducted at MD Anderson Cancer Center (Houston, TX, USA). Following a 4-week equilibration, patients were randomized to continue their usual diet without beans (control) or to add a daily cup of study beans to their usual diet (intervention) with immediate crossover at 8-weeks. Stool and fasting blood were collected every 4 …

Crispr-Cas9-Based Functional Interrogation Of Unconventional Translatome Reveals Human Cancer Dependency On Cryptic Non-Canonical Open Reading Frames, Caishang Zheng, Yanjun Wei, Peng Zhang, Kangyu Lin, Dandan He, Hongqi Teng, Ganiraju Manyam, Zhao Zhang, Wen Liu, Hye Rin Lindsay Lee, Ximing Tang, Wei He, Nelufa Islam, Antrix Jain, Yulun Chiu, Shaolong Cao, Yarui Diao, Sherita Meyer-Gauen, Magnus Höök, Anna Malovannaya, Wenbo Li, Ming Hu, Wenyi Wang, Han Xu, Scott Kopetz, Yiwen Chen

Faculty, Staff and Student Publications

Emerging evidence suggests that cryptic translation beyond the annotated translatome produces proteins with developmental or physiological functions. However, functions of cryptic non-canonical open reading frames (ORFs) in cancer remain largely unknown. To fill this gap and systematically identify colorectal cancer (CRC) dependency on non-canonical ORFs, we apply an integrative multiomic strategy, combining ribosome profiling and a CRISPR-Cas9 knockout screen with large-scale analysis of molecular and clinical data. Many such ORFs are upregulated in CRC compared to normal tissues and are associated with clinically relevant molecular subtypes. We confirm the in vivo tumor-promoting function of the microprotein SMIMP, encoded by a …

Women Leaders In The Oil And Gas Industry: How They Lead With Authenticity And Deal With Underrepresentation And Gender Bias In The Macro, Meso, And Micro Levels Of Society, Michelle Ann Ballard

Electronic Theses and Dissertations

This study was conducted between March 2023 and April 2023 and measured if women leaders in the oil and gas industry could lead authentically while dealing with gender biases. Women executives encounter macro-level challenges such as recruitment, retention, maintaining a career in oil and gas, feeling a sense of belonging, and gender prejudices. Women have faced organizational obstacles and challenges such as modifying their personalities, being underrepresented in their organization, unequal compensation, discriminatory stereotypes, and scarcity of resources. However, women in the industry also confront nonorganizational deterrents such as work-life conflict, harassment, and being regarded as poor advocates for their …

Concurrent Psychological Problems Among Multiple Sclerosis Patients In Germany And The United States, Jana Roehr

Electronic Theses and Dissertations

Despite increasing scientific interest over the past few decades in the neurobehavioral aspects of multiple sclerosis (MS), there has been relatively little systematic study of MS patients’ awareness of psychological problems. Even fewer data are currently available providing a direct comparison of the national prevalence rates of psychological problems among MS patients by country. This study was intended to address this question by comparing MS patients from Germany and the United States (US). Patients were asked to provide ratings of their psychological symptom severity, cognitive functioning, and overall quality of life (QoL) on six assessment instruments designed to assess depression, …