Digital Commons Network^™

The Relationship Between Biofouling Adhesion And Frequency Of Mechanical Cleaning To Control The Recruitment To Clear Coatings, Dylan Thomas Eggers

Theses and Dissertations

There is a need to control biofouling on sensors and transparent windows in the marine environment. Clear silicone coatings offer a method to reduce the adhesion strength of marine organisms to the surface, however, these also require mechanical cleaning to maintain the surfaces free of fouling. This research evaluated the performance of eighty seven formulations and took the top two candidates to investigate a) the frequencies of wiping required by a brush to maintain two coatings and uncoated glass surfaces free of fouling and b) the effects of clear silicone coatings fouling release properties on required frequencies. The panels were …

Steroid Receptor Coactivator-2 Drives Epithelial Reprogramming That Enables Murine Embryo Implantation, Vineet K Maurya, Maria M Szwarc, David M Lonard, Ramakrishna Kommagani, San Pin Wu, Bert W O'Malley, Francesco J Demayo, John P Lydon

Faculty, Staff and Students Publications

Although we have shown that steroid receptor coactivator-2 (SRC-2), a member of the p160/SRC family of transcriptional coregulators, is essential for decidualization of both human and murine endometrial stromal cells, SRC-2’s role in the earlier stages of the implantation process have not been adequately addressed. Using a conditional SRC-2 knockout mouse (SRC-2 ^d/d) in timed natural pregnancy studies, we show that endometrial SRC-2 is required for embryo attachment and adherence to the luminal epithelium. Implantation failure is associated with the persistent expression of Mucin 1 and E-cadherin on the apical surface and basolateral adherens junctions of the SRC-2 …

Tumor-Infiltrating Normal B Cells Revealed By Immunoglobulin Repertoire Clonotype Analysis Are Highly Prognostic And Crucial For Antitumor Immune Responses In Dlbcl, Zijun Y Xu-Monette, Yong Li, Thomas Snyder, Tiantian Yu, Tingxun Lu, Alexandar Tzankov, Carlo Visco, Govind Bhagat, Wenbin Qian, Karen Dybkaer, April Chiu, Wayne Tam, Youli Zu, Eric D Hsi, Fredrick B Hagemeister, Yingjun Wang, Heounjeong Go, Maurilio Ponzoni, Andrés J M Ferreri, Michael B Møller, Benjamin M Parsons, Xiangshan Fan, J Han Van Krieken, Miguel A Piris, Jane N Winter, Qingyan Au, Ilan Kirsch, Mingzhi Zhang, John Shaughnessy, Bing Xu, Ken H Young

Faculty, Staff and Students Publications

PURPOSE: Tumor-infiltrating B lymphocytes (TIL-B) have demonstrated prognostic and predictive significance in solid cancers. In this study, we aimed to distinguish TIL-Bs from malignant B-cells in diffuse large B-cell lymphoma (DLBCL) and determine the clinical and biological significance.

EXPERIMENTAL DESIGN: A total of 269 patients with de novo DLBCL from the International DLBCL R-CHOP Consortium Program were studied. Ultra-deep sequencing of the immunoglobulin genes was performed to determine B-cell clonotypes. The frequencies and numbers of TIL-B clonotypes in individual repertoires were correlated with patient survival, gene expression profiling (GEP) data, and frequencies of DLBCL-infiltrating immune cells quantified by fluorescent multiplex …

The Evolving Role Of Vericiguat In Patients With Chronic Heart Failure, Ross M. Dies, Corrie N. Jackson, Chelsi J. Flanagan, Evan S. Sinnathamby, Noah J. Spillers, Pooja Potharaju, Naina Singh, Giustino Varrassi, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye

School of Medicine Faculty Publications

Heart failure (HF) is a chronic and progressive clinical disorder characterized by an inability to pump sufficient blood to meet metabolic demands. It poses a substantial global healthcare burden, leading to high morbidity, mortality, and economic impact. Current treatments for HF include lifestyle modifications, guideline-directed medical therapies (GDMT), and device interventions, but the need for novel therapeutic approaches remains significant. The introduction of vericiguat, a soluble guanylate cyclase stimulator, has shown promise in improving outcomes for heart failure patients. Vericiguat addresses the underlying pathophysiological mechanisms of heart failure by augmenting the cyclic guanosine monophosphate (cGMP) pathway, leading to enhanced cardiac …

Chimeric Antigen Receptor T Cells In Hodgkin And T-Cell Lymphomas, Ibrahim N Muhsen, Laquisa C Hill, Carlos A Ramos

Faculty, Staff and Students Publications

The authors review the current use of chimeric antigen receptor (CAR)-transduced T cells (CAR-T) in Hodgkin lymphoma (HL) and T-cell lymphomas (TCL) and discuss the data on CD30-targeting CAR-T cells, which seem to be safe and effective in HL. In addition, the authors examine the use of CAR-T cells targeting CD30, CD5, or CD7 in TCL, while highlighting the unique challenges of their use in this subset of lymphomas. Furthermore, the authors present future directions and ongoing trials investigating the use of CAR-T cells in TCL and HL.

The Spatial And Temporal Distribution Of Large Rock Blocks And Control On Landscape Evolution In The Ozarks, Chelsea Moran

Graduate Theses and Dissertations

Geologists often use landscape form to infer landscape processes through time. While climate and tectonics shape geomorphic form, the potential range of spatial or temporal scales that can shape any specific landscape can render landscape process-form based hypotheses too general for consideration. Contributions by mathematical modeling have helped bridge the gap between inferring processes from form, notably in how sediment transport dynamics shape hillslopes. However, few models encapsulate the movement of large rock blocks ( >2 meters across) and their potential impact as hillslope sediment transport disruptors. The Upper Buffalo River watershed (BRW) in the Ozarks of northern Arkansas has …

Evaluation Of Weed Control Efficacy And Crop Tolerance To Florpyrauxifen-Benzyl Coated Onto Urea, Bodie Lyn Cotter

Graduate Theses and Dissertations

Frequent off-target movement occurrences to soybean [Glycine max (L.) Merr.], rice (Oryza sativa L.) injury, and a lack of barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.] control followed the commercial launch of florpyrauxifen-benzyl in 2018. Florpyrauxifen-benzyl is a synthetic auxin, Herbicide Resistance Action Committee (HRAC)/Weed Science Society of America (WSSA) Group 4 herbicide used for postemergence weed control in rice and labeled for application at 30 g ae ha-1. Previous research documented that soybean was susceptible to injury following spray applications of florpyrauxifen-benzyl at less-than-labeled rates, and certain varieties of rice are less tolerant to spray-applied florpyrauxifen-benzyl at 30 g ae …

National Emergency Department Sample In Geriatric Subsequent Mild Traumatic Brain Injury Visits And Associations With Sex, Falls, Payor, And Discharge Outcomes, Carrie Ann Barrett

Dissertations

The purpose of this study was to explore the variables of sex (male, female), fall mechanism of injury, payor source, and emergency department (ED) discharge outcomes in patients aged >65 who presented with mild traumatic brain injury (mTBI) subsequent ED visits.

A secondary data analysis was performed to assess the relationship among the independent and dependent variables listed above. The independent variables were dichotomous for age (>65, < 65), sex (male, female), and fall mechanism of injury (yes, no), and categorical for payor source (Medicare, Medicaid, Private, Other). The ED discharge dependent variables were categorical [home; healthcare services (including skilled nursing facility, home care, and intermediary care)]. Logistic regression analyses were performed to evaluate specific variables that increase the probability of affecting ED discharge outcomes. The software, SPSS v. 28 was used in the statistical calculations. The study was approved by the Western Michigan University Human Subjects Internal Review Board.

Investigation Of Public Trust In Science In Connection With Views About Tentative Nature Of Science And Epistemological Beliefs, Asghar Pervaiz Gill

Dissertations

Trust in science is contested in everyday discourse and decision-making. Science education research and instruction must delve into and contribute to enhancing public trust in science. In this context, nature of science (NOS), and epistemological beliefs (EBs) emerge as closely related research areas highlighting the tentative NOS and uncertain aspects of knowledge, which can potentially influence trust in science. In a series of three interrelated studies, this research explores the public trust in science in relation to NOS views and EBs.

The first study emphasizes the role of science education in building trust among undergraduate chemistry students. It assesses the …

Measuring Multicultural Competence In Counseling, Martha Mae Golubski

Dissertations

Pedersen (1999) described multicultural counseling as the “fourth force” in psychology. The description is used to imply that multiculturalism is the next theory to understand human behavior, complementary to the other three forces: psychodynamic, behavioral, and humanistic explanations. Despite the attention being given to multiculturalism, professional organizations, training institutions, and service providers are still trying to understand what it means to have competency in multicultural counseling. Researchers have made decades of efforts to define and measure multicultural counseling competence; yet, there is still limited data about how multicultural training efforts influence these competencies and how counselor multicultural competency affects clients’ …

Oncolytic Tanapoxvirus Recombinants Expressing Mil-2, Flagellin-C, And Mccl2 Regress Human Cancer Xenografts In Immune Deficient Nude Mice And Immune Cell Reconstituted Balb/C Nude Mice., Michael Leonard Monaco

Dissertations

Tanapoxvirus (TPV) is a double stranded DNA virus from the genus Yatapoxvirus which has been engineered for the purpose of potentially treating a number of human cancers. Previous studies have shown TPV recombinants are capable of inducing tumor inhibition and even regression in athymic nude mice bearing human cancer xenografts of colorectal, melanoma and triple negative breast cancer (TNBC). However, TPV is host-restricted to humans and monkeys, including cancerous cells, which has provided a unique obstacle in its development as an oncolytic virus (OV). Namely, standard syngeneic mouse models cannot be used as test systems to evaluate TPV’s efficacy against …

Analysis Of Trauma Screening As A Potential Predictor Of Congregate Care Placement As A Key Factor In Caseworker Decision Making, Amy Louise Perricone

Dissertations

The placement of foster care children into congregate care (CC) facilities has been debated regarding whether CC can provide safety and healing, or if it is harmful and retraumatizing to children. In recent years CC has come under scrutiny due to high per diem costs and increasing reports of abuse and even death of children. In response, the federal Families First Prevention Services Act (FFPSA) was enacted in 2018 with a goal of reducing the number of children in CC. Since then, efforts have been implemented nationwide to achieve this goal. This study explored the value of statewide trauma screening …

The Effects Of Adolescent Trauma, Mental Health Treatment, And Demographic Variables On Educational Outcome, Christopher Postema

Dissertations

Poor educational performance in adolescence can occur due to trauma, substance use, or other stressors. This study used conflict theory as a foundation, suggesting differences in educational outcomes can be attributed to systems perpetuating the current power structures that cause inequality in academic opportunities and performance. Trauma in adolescence can have adverse effects on educational outcomes and emotional stability. Research suggests that mental health therapy as well as a reduction in trauma symptoms can improve educational outcomes. Race, gender, substance use, socioeconomic status, and employment are important variables that could influence educational outcomes. Interaction terms were found in the literature …

Influence Of A Multicultural Counseling And Psychology Course On Counseling Psychology And Counselor Education Master’S Students Color-Blind Ideologies And Ethnic Identity, Rebecca Tuinstra

Dissertations

The primary purpose of this study was to examine whether ethnic identity awareness mediates the relationship between completion of a Multicultural Counseling and Psychology Course and color-blind ideology endorsement. The participants included 93 master’s level counseling psychology and counselor education trainees attending a predominantly White university in the Midwest region of the United States. The study used a quantitative, pre- and post-test descriptive research design. Using mediation analysis, this study estimated the influence of completing a Multicultural Counseling and Psychology Course on awareness of ethnic identity and use of color-blind ideology while controlling for social desirability among master’s level counseling …

Antiracist School Counseling Pedagogy: A Quasi-Experimental Multiple Regression Analysis, Star L. Zetocha

Dissertations

America’s K-12 schools, which were initially created exclusively for White children, are racialized institutions (Spring, 2019). School counseling ethics now obligate school counselors to engage in antiracist praxis in schools, yet school counselors-in-training (SCITs) are not typically provided with explicit training in antiracism, which allows them to enter the field with colorblind racial attitudes that inhibit them from recognizing and confronting racism in schools (Gibson & Fripp, 2022). The purpose of this research was to examine the relationship between colorblind racial attitudes and antiracist behaviors of school counselors in-training who had and had not taken an antiracist school counseling course. …

Transition Programs To Facilitate Employment For Young Adults With Autism Spectrum Disorder, Lillian I. Usen

Anthropology

It is well-documented in the literature that individuals with Autism Spectrum Disorder (ASD) have difficulty transitioning from school to the workforce. This group experiences challenges adjusting to the expectations of the workforce and a high unemployment rate is reported among adults with ASD. There are several notable barriers that inhibit adults with ASD from achieving gainful employment: inadequate preparation for the demands of the workforce, especially along vocational and social skill domains, are likely impacting this issue. Deficits in social skills and communication are reported as key factors that contribute to low employment and low employment skill retention among individuals …

Low Reynolds Number Locomotion Near Interfaces In Two-Fluid Media, Avriel Rowena Mae Cartwright

Theses and Dissertations

Microorganisms often swim within complex fluid environments composed of multiple materials with very different properties. Biological locomotion, including swimming speed, is significantly impacted by the physical composition and rheology of the surrounding fluid environment, as well as the presence of phase boundaries and free interfaces, across which physical properties of the fluid media may vary greatly. Through computational simulations, we first investigate the classical Taylor’s swimming sheet problem near interfaces within multi-fluid environments using a two-fluid immersed boundary method. The accuracy of the methodology is illustrated through comparisons with analytical solutions. Our simulation results indicate that the interface dynamics and …

Constraining Silicate Weathering During The Middle Eocene Climatic Optimum (Meco) Using Radiolarian Ge/Si, Olivia R. Laub

All Graduate Theses and Dissertations, Fall 2023 to Present

Silicate weathering has long been considered a fundamental component of the earth system and has been cited as one of, if not the primary stabilizing feedback for climate. However, recent work has shown that the role of silicate weathering in the climate system is more complicated and dynamic than previously assumed. In this study I examine the role of weathering in the enigmatic warming event, the Middle Eocene Climatic Optimum (MECO) that occurred approximately 40 Ma. This event works as a good case study as there are multiple features of the MECO that differentiate it from other warming events that …

Analyzing The Impacts Of Beaver Dam And Beaver Dam Analog Complexes To Stream Ecology Within The Intermountain West, J. Marshall Wolf

All Graduate Theses and Dissertations, Fall 2023 to Present

Streams, rivers, and their floodplains throughout the world are impaired due to human modifications. Recent research has demonstrated that restoration projects prioritizing the proper functioning of ecosystems have better restoration outcomes than projects which focus on restoring form alone. Throughout North America, beaver-mediated restoration is becoming a leading method for improving the functioning of stream ecosystems that are in a degraded state. In areas where beaver are absent or the habitat is too degraded to currently permit their dam building, man-made beaver dam analogs (BDAs) are being used to restore stream habitat with an eye to future beaver recolonization. However, …

Rabrs For Use In Biologically Enhanced Precipitation Of Struvite In Anaerobic Digester Effluent (Municipal Wastewater), Parker R. Goldsberry

All Graduate Theses and Dissertations, Fall 2023 to Present

Rotating Algae Biofilm Reactor (RABR) technology has been researched in studies over the past decade directed at nutrient management for water resource recovery facilities (WRRFs). This study investigated the growth of slow-release fertilizer crystals, referred to as struvite, in the algae biofilms of Rotating Algae Biofilm Reactors (RABRs) at the Central Valley Water Reclamation Facility, the largest water resource recovery facility in the State of Utah. RABRs used anaerobic digester (AD) filtrate as their nutrient source. AD effluent is high in nutrients like nitrogen and phosphorus. The levels of both phosphorus and nitrogen (in the form of ammonia) are regulated …

Linking Microbial Community Assembly In Flowers With Function Under Diverse Environmental Conditions: A Case Study Involving Erwinia Amylovora, Christopher Skylar Mcdaniel

All Graduate Theses and Dissertations, Fall 2023 to Present

Fire blight, a devastating disease of pome fruit trees caused by the bacterium Erwinia amylovora, can cause millions of dollars in losses for producers each year around the globe. Management approaches that involve use of antibiotics, such as streptomycin, can be effective; although concerns exist over pollinator and crop health when using them regularly. Recently, there have been developments that allow for biological agents such as microbes to curtail fire blight infection. These agents work by competing with Erwinia for resources or space, producing antibacterial compounds, or even killing Erwinia cells on contact. Unfortunately, these agents do not yet …

The Effects Of An Equine Riding Simulator As An Objective Feedback Modality On Learning Outcomes For Rider Competency On Performance Skills In Equestrian Riding Fundamentals, Kelli Munns

All Graduate Theses and Dissertations, Fall 2023 to Present

This study examined the effects of different feedback modalities provided during simulated-based practice on performance and perceptions. In addition, the research also addressed the relationship between participants' feedback literacy, perceptions, and improvement scores. The purpose of this research was motivated by the emerging equine simulation technology that provides feedback on movement and coordination during complex motor skill acquisition. Selecting an effective feedback approach for simulation-based practice in motor skill learning is contingent on the complexity of the performance skill and the learner's experience. However, the learner's feedback literacy can result in contradictory performance and perceptions despite the feedback approach experienced. …

An Overview Of Sustainability Content In Higher Education: Applications For University Landscape Architecture Programs, Hye Yeon Park

All Graduate Theses and Dissertations, Fall 2023 to Present

Higher education institutions worldwide have recognized the importance of integrating sustainability into their programs, with over 600 universities offering courses focused on sustainable development. This trend has led to the emergence of Education for Sustainable Development (ESD). This multidimensional approach aims to empower individuals to create a sustainable future by integrating environmental, social, and economic systems. In particular, ESD has been implemented in various aspects of higher education, such as course content, teaching methodologies, curriculum design, and faculty roles.

Design and planning education are critical components of shaping future decision-makers who will positively and negatively impact society and the environment. …

Characterization Of Enterovirus D68 In A Mouse Model And Evaluation Of Antiviral Therapies, Zoe K. Taylor

All Graduate Theses and Dissertations, Fall 2023 to Present

Enterovirus D68 (EV-D68) is a virus that causes respiratory disease. Children are most commonly affected by EV-D68 but immunocompromised adults can also get infected and develop severe disease signs. In 2014, the United States experienced an unprecedented outbreak of EV-D68. Similar outbreaks were also observed in 2016, 2018 and 2022. Interestingly, few EV-D68 infections were observed in 2020, likely due to public health measures put in place to reduce the spread of another respiratory disease, coronavirus disease 2019 (COVID-19). EV-D68 is in the same virus family as polio, and one of the most concerning findings from these outbreaks is that …

Mattering And Attachment: A Bilateral Association That Underlies Relationship Outcomes In Couples, Jacob Ybarra

All Graduate Theses and Dissertations, Fall 2023 to Present

In this master's thesis, I conducted a quantitative study using data from 100 heterosexual couples in a committed, romantic relationship to better understand the relationship between perceived mattering (PM) and attachment and to explore how mattering relates to various mental health and relationship outcomes. All 200 partners independently completed an online anonymous questionnaire consisting of various quantitative assessments measuring my study variables (e.g., attachment, PM, and relationship and mental health outcomes).

I used dyadic data analysis to examine how study variables related to an individual's outcomes as well as their partner's. Overall, findings from the first analysis highlighted that men …

Computational Study About Noncovalent Bonding Systems Involving Halogen, Chalcogen And Pnicogen Bonds, Jia Lu

All Graduate Theses and Dissertations, Fall 2023 to Present

First terms used in this thesis are introduced and defined as follows. In the periodic table, the elements in the 17^th column are named halogen including fluorine (F), chlorine (Cl), bromine (Br) and iodine (I). The elements in the 16^th column are named chalcogen including oxygen (O), sulfur (S), selenium (Se) and tellurium (Te). The elements in the 15^th column are named pnicogen including nitrogen (N), phosphorus (P), arsenic (As) and antimony (Sb).

After hydrogen bonds (B-H⋅⋅⋅B) are well studied and understood by scientists and researchers, halogen bonds (R-X⋅⋅⋅B) have drawn attention due to the similarities in …

Balsam Woolly Adelgid And Host Forest Characteristics: Impacts And Interactions In Recently Invaded Areas Of Northern Utah And Southeastern Idaho, Grayson B. Jordan

All Graduate Theses and Dissertations, Fall 2023 to Present

The balsam woolly adelgid (BWA), is an invasive forest insect native to central and southern Europe. In 2017, it was detected in Utah for the first time. While BWA had limited impact as a pest in its native European range, it has caused considerable damage to true fir populations in North America. In the Intermountain region, subalpine fir has been identified as the tree species most at risk of BWA infestation. Subalpine fir provides a variety of ecosystem services and is a critical component of the spruce-fir alpine forests of the area. With an expected increase in the severity and …

Evaluating The Effects Of Ketamine On Cognitive Flexibility In Rats Using A Probabilistic Reversal Learning Task, Anthony N. Nist

All Graduate Theses and Dissertations, Fall 2023 to Present

Depression is one of the most debilitating and widespread mental health conditions in the world today. Drugs that are traditionally prescribed to combat depression are flawed in several ways, and because of this, new treatments are needed. One drug that seems capable of overcoming the limitations of traditional antidepressants is ketamine. In clinical research, a single dose of ketamine can significantly reduce symptoms of depression quickly, its effects may last for weeks to months, and its side effects appear to be limited and relatively harmless. However, clinical research is ongoing, and more research is needed to fully understand ketamine's beneficial …

Inundated Vegetation Response To Ongoing Restoration And Its Impacts On Fish Community Structure, Emmanuel J. May

All Graduate Theses and Dissertations, Fall 2023 to Present

Shallow lake ecosystems and their associated wetland habitats globally are subject to non-native species introductions, nutrient loading, and water level fluctuations, each of which can decrease vegetated habitat availability, exposing vulnerable native aquatic species to predation. Managers are frequently tasked with mitigating native species declines by restoring vegetation considered crucial for their survival. However, restoring vegetation can be challenging in the presence of multiple stressors, requiring managers to assess the relative importance of the different stressors limiting vegetation recovery.

Utah Lake is a large shallow lake subject to multiple stressors and has shifted from a mesotrophic lake with abundant aquatic …

Using Pavlovian Sign-Tracking To Increase Self-Control In Rats, Saba Mahmoudi

All Graduate Theses and Dissertations, Fall 2023 to Present

Impulsivity is correlated with various maladaptive behaviors (e.g., gambling and substance-used disorders), therefore many studies have been designed to find methods to reduce impulsive choice. Although these procedures (e.g., delay fading and delay-exposure training) are effective, they involve extended training durations. One method that has not yet been explored in promoting self-control is Pavlovian conditioning. During Pavlovian conditioning, a localized conditioned stimulus (CS) that signals an imminent food delivery can (a) evoke sign-tracking behavior (i.e., attraction to, and physically interacting with the CS) and (b) function as a conditioned reinforcer (i.e., the subject will work to access the CS). This …