Digital Commons Network^™

Preventing Conversion To A Highly Degraded Invasive Dominated System, C. V. Ransom

IGC Proceedings (1977-2023)

Invasive annual grasses (IAG) negatively impact rangeland across the Western US. Within the Intermountain Region, downy brome, Japanese brome, medusahead, and ventenata are among the most prevalent invasive annual grass species. Research conducted at Utah State University has addressed numerous approaches to IAG management as well investigating restoration strategies of highly degraded sites. Under harsh climates common to the Western US, restoration has been extremely challenging, causing focus to shift towards prioritizing the protection of existing desirable plant communities. In either restoration or plant community protection approaches, annual rainfall is the largest driver of success. Changes or shifts in plant …

Red Deer Browsing Decelerates Shrub Regrowth Despite Increasing Wolf Presence, F. Riesch, C. Raab, Bettina Tonn, N. Gerber, M. Zetsche, J. Signer, Marcus Meißner, Sven Herzog, Niko Balkenhol, Johannes Isselstein

IGC Proceedings (1977-2023)

Semi-natural open habitats in Europe have been shaped by traditional land use practices, such as extensive mowing or livestock grazing. However, socio-economic transformations have led to the abandonment of many grassland and heathland areas and conservation management is now required to maintain these biodiverse habitats. Grazing by wild red deer (Cervus elaphus) can be a convenient alternative to laborious mechanical management or livestock grazing. Yet it remains unclear if free-ranging ungulates can counteract shrub growth sufficiently to maintain open habitats—especially with natural predators, i.e. wolves (Canis lupus), recolonizing Europe. To assess red deer effects on shrub …

Using Recurrent Phenotypical Selection To Improve Drought Tolerance Of Red Clover, M. Sahin, S. Reid, E. Sahin, S. Ates, S. Elias, David B. Hannaway

IGC Proceedings (1977-2023)

Red clover is one of the most important forage legumes in the world. It is utilized extensively in European and North American farming systems. Approximately, 4 million hectares of red clover are grown globally each year for forage production, soil improvement, and as a pollen and nectar source for pollinators (Riday, 2010). In North America, red clover is widely used in temperate regions for pasture, hay, and silage in combination with grasses for soil improvement and as a pollen and nectar source for bumblebees (Bombus). In the northwest, it is also grown for seed production (Anderson et al., 2016) with …

Legumes As A Biological Tool To Address The Sustainability Of Ruminant Production Systems, H. Sheridan, M. B. Lynch

IGC Proceedings (1977-2023)

Growing public concern regarding accelerated rates of climate change, the depletion and degradation of natural resources such as biodiversity water and soils, coupled with policy commitments to address these challenges, are placing increasing pressures to enhance sustainability metrics associated with agriculture in general, and ruminant production systems in particular. At EU and indeed global scale, there has probably never before been so many potentially conflicting challenges for agriculture. On one hand, agricultural systems need to produce more, to feed the increasing global human population, while at the same time being much less reliant on economically and environmentally costly chemical inputs …

How Do Artemisia Capillaris Population Respond To Grazing Management And Rain Reduction?, Li-Yuan Shi, Fu-Jiang Hou, Zhen Wang

IGC Proceedings (1977-2023)

Climate and human activities, such as drought event and livestock grazing, generally coupled to influence the structure and function of grassland ecosystems. However, most of previous studies focused on the isolated effects of grazing or drought on grassland ecosystems, with little attention paid to the combined effects of them. Further, we know little about how plants respond to grazing and drought at the population level. We conducted a grazing regime (enclosure, stop grazing, and heavy grazing) and drought manipulation experiment in a typical steppe to explore how grassland plants response to ongoing drought and grazing regimes at the population level. …

Development Of Forage Curriculum For Extension Educators In The Southeast Usa, L. S. Silva, L. Dillard, K. Mullenix, M. Wallau, J. J. Tucker, C. Vasco

IGC Proceedings (1977-2023)

In the Southeast USA, livestock production is one of the largest agricultural activities, and forages are the primary feed source. Most livestock systems are highly dependent on off-farm inputs to support forage production and animal performance, which elevates production costs and the activity's carbon footprint. There is a strong need to develop forage educational resources to enhance productivity, environmental sustainability, resilience, and profitability of agricultural systems in the region. This multi-disciplinary initiative was a collaboration among several land-grant Universities across the region. The objective was to develop decision tools and provide in-classroom training associated with hands-on demonstrations to Extension agents …

Kinship, Gift Exchange, And The Management Of Diabetes, Bryen Turco, Vito Agrusa, Laila Abdallah, James Peter Meza

Clinical Research in Practice: The Journal of Team Hippocrates

The authors examine the impact of kinship structures on the management poorly controlled type 2 diabetes

Steminism: Analyzing Factors That Improve Retention Of Women In Stem, Kira Carter, Jane Kelley, Jason Vasser-Elong, Rc Patterson

Dissertations

Our co-authored research ‘Steminism: Analyzing Factors That Improve Retention for Women as STEM Majors’ analyzed factors that contributed to the retention of women in science, technology, engineering, and mathematics (STEM) programs at Missouri University of Science & Technology (Missouri S&T). Women make up half of the US population, and while careers in (STEM) are an integral part of the US economy, women are underrepresented in these career fields. The purpose of our dissertation is to address the underrepresentation of women in STEM majors. Our methodology included homogeneous sampling to collect qualitative data. More specifically, we consulted with academic advisors and …

Cagi, The Critical Assessment Of Genome Interpretation, Establishes Progress And Prospects For Computational Genetic Variant Interpretation Methods., The Critical Assessment Of Genome Interpretation Consortium

Faculty Research 2024

BACKGROUND: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic variant impact, particularly where relevant to disease. The five complete editions of the CAGI community experiment comprised 50 challenges, in which participants made blind predictions of phenotypes from genetic data, and these were evaluated by independent assessors.

RESULTS: Performance was particularly strong for clinical pathogenic variants, including some difficult-to-diagnose cases, and extends to interpretation of cancer-related variants. Missense variant interpretation methods were able to estimate biochemical effects with increasing accuracy. Assessment of methods for regulatory variants and complex trait disease risk was …

The Current - Volume 34 Issue 9, Nova Southeastern University

Student Newspapers

No abstract provided.

Trex Tetramer Disruption Alters Rna Processing Necessary For Corticogenesis In Thoc6 Intellectual Disability Syndrome., Elizabeth A Werren, Geneva R Laforce, Anshika Srivastava, Delia R Perillo, Shaokun Li, Katherine Johnson, Safa Baris, Brandon Berger, Samantha L Regan, Christian D Pfennig, Sonja De Munnik, Rolph Pfundt, Malavika Hebbar, Raúl Jimenez-Heredia, Elif Karakoc-Aydiner, Ahmet Ozen, Jasmin Dmytrus, Ana Krolo, Ken Corning, E J Prijoles, Raymond J Louie, Robert Roger Lebel, Thuy-Linh Le, Jeanne Amiel, Christopher T Gordon, Kaan Boztug, Katta M Girisha, Anju Shukla, Stephanie L Bielas, Ashleigh E Schaffer

Faculty Research 2024

THOC6 variants are the genetic basis of autosomal recessive THOC6 Intellectual Disability Syndrome (TIDS). THOC6 is critical for mammalian Transcription Export complex (TREX) tetramer formation, which is composed of four six-subunit THO monomers. The TREX tetramer facilitates mammalian RNA processing, in addition to the nuclear mRNA export functions of the TREX dimer conserved through yeast. Human and mouse TIDS model systems revealed novel THOC6-dependent, species-specific TREX tetramer functions. Germline biallelic Thoc6 loss-of-function (LOF) variants result in mouse embryonic lethality. Biallelic THOC6 LOF variants reduce the binding affinity of ALYREF to THOC5 without affecting the protein expression of TREX members, implicating …

A Spatio-Temporal Modelling Approach To Understand The Effect Of Urban Fruit Fly Outbreaks On Peri-Urban Orchards, Andrew Broadley, Rieks Van Klinken, Dean R. Paini, Matthew Hill, Elliot T. Howse

Horticulture Research Articles

Urban areas are well-known sources of fruit fly introduction and unmanaged populations pose a high risk of dispersal to surrounding agricultural areas. Although management of urban fruit fly populations is recognised as being important for area-wide control programmes, its relative importance is rarely quantified. Identifying possible sources of fruit fly populations is important to the success of area-wide programs, as well as to on-farm management. We developed a modelling approach to analyse the spatio-temporal connectivity of fruit fly across urban-agriculture boundaries. For a case study, we examine Mediterranean fruit fly, Ceratitis capitata, outbreaks in two fruit growing …

Spectator 2024-02-22, Editors Of The Spectator

The Spectator

No abstract provided.

Illuminating How Nestling Mouth Color And Body Size Shape Parental Care In A Cavity-Nesting Species, Shana Border

Theses and Dissertations

Young animals often solicit care from their parents using behaviors and morphologies collectively termed begging, and for many nestling birds these begging displays include presenting their parents with vividly colored mouthparts. Mouth color is a complex trait that varies both across and within species, and different aspects of color may be under independent selection and serve different functions; the two primary proposed explanations for the evolution of mouth color are to increase nestling conspicuousness to parents and to provide parents with information about nestling quality. In addition to signals like mouth color, parents could also directly assess traits like nestling …

The Effect Of Institutionalized Barriers On Historically Excluded Athletic Training Students, Chelsea Kuehner-Boyer

Theses and Dissertations

The Institute of Medicine has found that barriers exist that directly contribute to the underrepresentation of racial and ethnic groups in health professional education. Yet, little research has been done to evaluate the barriers that affect athletic training students. An integrative review was conducted to identify barriers that affect students in professional healthcare programs, and 52 articles were retained to create an original survey to measure the barriers faced by athletic training students. The purpose of this study is to understand the barriers that affect athletic training students, especially athletic training students from historically excluded groups. This study hypothesizes that …

Research Experiences Via Integrating Simulations And Experiments (Revise): A Model Collaborative Research Project For Undergraduate Students In Co2 Sorbent Design, Anthony Griffin, Neziah Smith, Mark Robertson, Bianca Nunez, Jacob Mccraw, Haoyuan Chen, Zhe Qiang

Physics & Astronomy Faculty Publications

Undergraduate research experiences are an instrumental component of student development, increasing conceptual understanding, promoting inquiry-based learning, and guiding potential career aspirations. Moving one step further, as research continues to become more interdisciplinary, there exists potential to accelerate student growth by granting additional perspectives through collaborative research. This study demonstrates the utilization of a model collaborative research project, specifically investigating the development of sorbent technologies for efficient CO2 capture, which is an important research area for improving environmental sustainability. A model CO2 sorbent system of heteroatom-doped porous carbon is utilized to enable students to gain knowledge of adsorption processes, through combined …

The Grizzly, February 22, 2024, Marie Sykes, Kathy Logan, Sidney Belleroche, Kate Horan, Andrew J. Perez, Dominic Minicozzi, James Rapp

Ursinus College Grizzly Newspaper, 1978 to Present

Voluntary Retirement Program: Limited Time Offer • Senior Class Celebrated 100 Days Till Graduation • Which Justices are Just? • A Conversation With Esther Akande: Recently-Graduated President of SUN • New Dungeons & Dragons Club: "The Only Limit is Your Imagination!" • Sedona Taphouse's Satisfying Eats • Painting the Postseason Picture • Ursinus Men's LAX on the Attack!

Tailoring T Fh Profiles Enhances Antibody Persistence To A Clade C Hiv-1 Vaccine In Rhesus Macaques, Anil Verma, Chase E. Hawes, Sonny R. Elizaldi, Justin C. Smith, Dhivyaa Rajasundaram, Gabriel Kristian Pedersen, Xiaoying Shen, La Tonya D. Williams, Georgia D. Tomaras, Pamela A. Kozlowski, Rama R. Amara, Smita S. Iyer

School of Medicine Faculty Publications

CD4 T follicular helper cells (Tfh) are essential for establishing serological memory and have distinct helper attributes that impact both the quantity and quality of the antibody response. Insights into Tfh subsets that promote antibody persistence and functional capacity can critically inform vaccine design. Based on the Tfh profiles evoked by the live attenuated measles virus vaccine, renowned for its ability to establish durable humoral immunity, we investigated the potential of a Tfh1/17 recall response during the boost phase to enhance persistence of HIV-1 Envelope (Env) antibodies in rhesus macaques. Using a DNA-prime encoding gp160 antigen and Tfh polarizing cytokines …

Establishment And Characterization Of Turtle Liver Organoids Provides A Potential Model To Decode Their Unique Adaptations, Christopher Zdyrski, Vojtech Gabriel, Thea B. Gessler, Abigail Ralston, Itzel Sifuentes-Romero, Debosmita Kundu, Sydney Honold, Hannah Wickham, Marco Arriaga, Jacob Galan

School of Medicine Publications

Painted turtles are remarkable for their freeze tolerance and supercooling ability along with their associated resilience to hypoxia/anoxia and oxidative stress, rendering them an ideal biomedical model for hypoxia-induced injuries (including strokes), tissue cooling during surgeries, and organ cryopreservation. Yet, such research is hindered by their seasonal reproduction and slow maturation. Here we developed and characterized adult stem cell-derived turtle liver organoids (3D self-assembled in vitro structures) from painted, snapping, and spiny softshell turtles spanning ~175My of evolution, with a subset cryopreserved. This development is, to the best of our knowledge, a first for this vertebrate Order, and complements the …

Tubular Cpt1a Deletion Minimally Affects Aging And Chronic Kidney Injury, Safaa Hammoud, Yosuke Osaki, Steven Funk, Dongliang Lu, Benjamin D. Humphreys, Jeffrey Koenitzer, Justin Kern, Nidia Messias, Irfan J Lodhi, Leslie S. Gewin, Et Al.

2020-Current year OA Pubs

Kidney tubules use fatty acid oxidation (FAO) to support their high energetic requirements. Carnitine palmitoyltransferase 1A (CPT1A) is the rate-limiting enzyme for FAO, and it is necessary to transport long-chain fatty acids into mitochondria. To define the role of tubular CPT1A in aging and injury, we generated mice with tubule-specific deletion of Cpt1a (Cpt1aCKO mice), and the mice were either aged for 2 years or injured by aristolochic acid or unilateral ureteral obstruction. Surprisingly, Cpt1aCKO mice had no significant differences in kidney function or fibrosis compared with wild-type mice after aging or chronic injury. Primary tubule cells from aged Cpt1aCKO …

Immunotherapy Resistance In Solid Tumors: Mechanisms And Potential Solutions, Daniel Lefler, Steven Manobianco, Babar Bashir

Kimmel Cancer Center Faculty Papers

While the emergence of immunotherapies has fundamentally altered the management of solid tumors, cancers exploit many complex biological mechanisms that result in resistance to these agents. These encompass a broad range of cellular activities - from modification of traditional paradigms of immunity via antigen presentation and immunoregulation to metabolic modifications and manipulation of the tumor microenvironment. Intervening on these intricate processes may provide clinical benefit in patients with solid tumors by overcoming resistance to immunotherapies, which is why it has become an area of tremendous research interest with practice-changing implications. This review details the major ways cancers avoid both natural …

Cagi, The Critical Assessment Of Genome Interpretation, Establishes Progress And Prospects For Computational Genetic Variant Interpretation Methods, Critical Assessment Of Genome Interpretation Consortium

Faculty, Staff and Student Publications

BACKGROUND: The Critical Assessment of Genome Interpretation (CAGI) aims to advance the state-of-the-art for computational prediction of genetic variant impact, particularly where relevant to disease. The five complete editions of the CAGI community experiment comprised 50 challenges, in which participants made blind predictions of phenotypes from genetic data, and these were evaluated by independent assessors.

RESULTS: Performance was particularly strong for clinical pathogenic variants, including some difficult-to-diagnose cases, and extends to interpretation of cancer-related variants. Missense variant interpretation methods were able to estimate biochemical effects with increasing accuracy. Assessment of methods for regulatory variants and complex trait disease risk was …

Estrogen Receptor Mutations As Novel Targets For Immunotherapy In Metastatic Estrogen Receptor-Positive Breast Cancer, Jonathan Goldberg, Na Qiao, Jennifer L Guerriero, Brett Gross, Yagiz Meneksedag, Yoshimi F Lu, Anne V Philips, Tasnim Rahman, Funda Meric-Bernstam, Jason Roszik, Ken Chen, Rinath Jeselsohn, Sara M Tolaney, George E Peoples, Gheath Alatrash, Elizabeth A Mittendorf

Faculty, Staff and Student Publications

UNLABELLED: Estrogen receptor-positive (ER+) breast cancer is not considered immunogenic and, to date, has been proven resistant to immunotherapy. Endocrine therapy remains the cornerstone of treatment for ER+ breast cancers. However, constitutively activating mutations in the estrogen receptor alpha (ESR1) gene can emerge during treatment, rendering tumors resistant to endocrine therapy. Although these mutations represent a pathway of resistance, they also represent a potential source of neoepitopes that can be targeted by immunotherapy. In this study, we investigated ESR1 mutations as novel targets for breast cancer immunotherapy. Using machine learning algorithms, we identified ESR1-derived peptides predicted to form stable complexes …

Establishment And Characterization Of Turtle Liver Organoids Provides A Potential Model To Decode Their Unique Adaptations, Christopher Zdyrski, Vojtech Gabriel, Thea B. Gessler, Abigail Ralston, Itzel Sifuentes-Romero, Debosmita Kundu, Sydney Honold, Hannah Wickham, Nicholas E. Topping, Dipak Kumar Sahoo, Basanta Bista, Jeffrey Tamplin, Oscar Ospina, Pablo Piñeyro, Marco Arriaga, Jacob A. Galan, David K. Meyerholz, Karin Allenspach, Jonathan P. Mochel, Nicole Valenzuela

Faculty Publications

Painted turtles are remarkable for their freeze tolerance and supercooling ability along with their associated resilience to hypoxia/anoxia and oxidative stress, rendering them an ideal biomedical model for hypoxia-induced injuries (including strokes), tissue cooling during surgeries, and organ cryopreservation. Yet, such research is hindered by their seasonal reproduction and slow maturation. Here we developed and characterized adult stem cell-derived turtle liver organoids (3D self-assembled in vitro structures) from painted, snapping, and spiny softshell turtles spanning ~175My of evolution, with a subset cryopreserved. This development is, to the best of our knowledge, a first for this vertebrate Order, and complements the …

Immunostimulatory Short Non-Coding Rnas In The Circulation Of Patients With Tuberculosis Infection, Justin Gumas, Takuya Kawamura, Megumi Shigematsu, Yohei Kirino

Computational Medicine Center Faculty Papers

Mycobacterium tuberculosis (Mtb) infection is among the world's deadliest infectious diseases. Developing effective treatments and biomarkers for tuberculosis requires a deeper understanding of its pathobiology and host responses. Here, we report a comprehensive characterization of circulating short non-coding RNAs (sncRNAs) in plasma samples from Mtb-infected patients. We achieved this by pre-treating plasma RNAs with T4 polynucleotide kinase to convert all RNA ends to those compatible with sncRNA sequencing. We discovered a global and drastic upregulation of plasma sncRNAs in Mtb-infected patients, with tRNA-derived sncRNAs representing the most dramatically elevated class. Most of these tRNA-derived sncRNAs originated from a limited subset …

Application Of Dna Barcodes In The Genetic Diversity Of Hard Ticks (Acari: Ixodidae) In Kazakhstan, Ziwei Zheng, Weixin Zeng, Suwen Wang, Wenbo Tan, Xiaobo Lu, Kenesbay Kairullayev, Ligu Mi, Wurelihazi Hazihan, Gang Liu, Meihua Yang, Yuanzhi Wang

Harold W. Manter Laboratory of Parasitology: Library Materials

Forty-five tick species have been recorded in Kazakhstan. However, their genetic diversity and evolutionary relationships, particularly when compared to ticks in neighbouring countries, remain unclear. In the present study, 148 mitochondrial cytochrome c oxidase subunit I (COI) sequence data from our laboratory and NCBI (National Center for Biotechnology Information; https://www.ncbi.nlm.nih.gov/) data were used to address this knowledge gap. Phylogenetic analyses showed that i) Hyalomma anatolicum anatolicum (Koch, 1844) ticks from Jambyl Oblast (southeastern Kazakhstan) and Gansu Province (northwestern China) constituted a newly deviated clade; and ii) Dermacentor reticulatus (Fabricius, 1974) ticks from South Kazakhstan Oblast were closer …

Montana Kaimin, February 22, 2024, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

What Diameter? What Height? Influence Of Measures Of Average Tree Size On Area-Based Allometric Volume Relationships, Yilin Wang, John A. Kershaw, Mark J. Ducey, Yuan Sun, James B. Mccarter

Faculty Publications

Volume is an important attribute used in many forest management decisions. Data from 83 fixed-area plots located in central New Brunswick, Canada, are used to examine how different measures of stand-level diameter and height influence volume prediction using a stand-level variant of Honer's (1967) volume equation. When density was included in the models (Volume=f(Diameter,Height,Density)) choice of diameter measure was more important than choice of height measure. When density was not included (Volume=f(Diameter,Height)), the opposite was true. For models with density included, moment-based estimators of stand diameter and height performed better than all other measures. For models without density, largest tree …

What Diameter? What Height? Influence Of Measures Of Average Tree Size On Area-Based Allometric Volume Relationships, Yilin Wang, John A. Kershaw, Mark J. Ducey, Yuan Sun, James B. Mccarter

Faculty Publications

Volume is an important attribute used in many forest management decisions. Data from 83 fixed-area plots located in central New Brunswick, Canada, are used to examine how different measures of stand-level diameter and height influence volume prediction using a stand-level variant of Honer's (1967) volume equation. When density was included in the models (Volume=f(Diameter,Height,Density)) choice of diameter measure was more important than choice of height measure. When density was not included (Volume=f(Diameter,Height)), the opposite was true. For models with density included, moment-based estimators of stand diameter and height performed better than all other measures. For models without density, largest tree …

Factors Associated With Reduced Depression And Suicide Risk Among Mäori High School Students In New Zealand, Terryann C. Clark

Dissertations

Mäori adolescents, indigenous to New Zealand (NZ), have among the highest rates of depression and suicide in the industrialized world. Fortunately, resilience research demonstrates that promotive factors, such as family and school connections, can markedly reduce mental health problems for vulnerable youth populations. However, to date, this research has never focused on risk and promotive mechanisms related to mental health outcomes for Mäori youth. Such knowledge is a prerequisite for addressing the persistent mental health inequities faced by Mäori young people.