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Investigating The Management Of Covid-19 Pandemic Risks In Primary Schools: A Case Of Public Primary Schools In Lindi Region, Southern Tanzania, Emmanuel Mutura, Winston Edward Massam, Mary Oluga, Jane Rarieya, Nyagwegwe Wango Mar 2024

Investigating The Management Of Covid-19 Pandemic Risks In Primary Schools: A Case Of Public Primary Schools In Lindi Region, Southern Tanzania, Emmanuel Mutura, Winston Edward Massam, Mary Oluga, Jane Rarieya, Nyagwegwe Wango

Institute for Educational Development, East Africa

The spread of COVID-19 in the year 2020 put various nations at risk, especially in social, economic, and educational aspects. School closure was employed as one of the response measures against the spread of this virus. However, the measure imposed high social and educational risks with consequences of a massive drop academically. This study investigated the management of the COVID-19 pandemic risks in primary schools in the Lindi region in Tanzania intending to suggest the essence of having a risk management plan for indeterminate outbreaks and other uncertainties to avoid the recurrence of the risks. The study adopted a qualitative …

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Diondre Also Has Bad Days: Cannabis Use And The Criminalization Of Black Youth, Rommel Johnson Mar 2024

Diondre Also Has Bad Days: Cannabis Use And The Criminalization Of Black Youth, Rommel Johnson

School of Rehabilitation Services & Counseling Faculty Publications

Black, school-aged youth may experience socioeconomic, psychological, and emotional difficulties that affect their mental health, leading to maladaptive ways of coping, such as cannabis use. Instead of getting treatment and support to help them manage their stressors in positive ways, Black youth often receive punitive school practices, including referrals to the juvenile justice system. Counselors who work with school-aged youth are likely to encounter many Black youth and can thus either be instrumental to their psychological development or inadvertently impede their well-being with over-pathologization and criminalization of their cannabis use. In this article, the author reflects on a particular experience …

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The Optimisation Of A Customised Methodology For The Determination Of The Lime Requirement Of Irish Soils, Fionan Mackessy Mar 2024

The Optimisation Of A Customised Methodology For The Determination Of The Lime Requirement Of Irish Soils, Fionan Mackessy

Theses

Soil pH plays a pivotal role in agricultural productivity and environmental sustainability, influencing various soil processes crucial for plant growth and ecosystem functions. It is a master variable that affects the biological, chemical and physical properties of soil. Maintaining a correct soil pH – generally through the addition of a liming product - is central to sustainable and productive agriculture and therefore accurate determination of soil pH is a vital piece of information that is central to any soil lab test. However, the accuracy of any soil pH test will be dictated by a number of soil properties such as …

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Applications Of Plastics In The Automotive Industry: Current Trends And Future Perspectives, Hossein Abedsoltan Mar 2024

Applications Of Plastics In The Automotive Industry: Current Trends And Future Perspectives, Hossein Abedsoltan

Chemical and Biochemical Engineering Faculty Research & Creative Works

Plastics have transformed the automotive industry, contributing substantially to automobile design, weight reduction, fuel efficiency, safety, and sustainability. This review paper examines the applications of plastics in the automotive sector, evaluates the present trends, and describes the future plastic consumption possibilities, emphasizing emerging technology and sustainable practices. The paper delineates how plastics have become an essential component of automotive innovation and illustrates the possibilities for additional breakthroughs in this dynamic industry. Highlights: Advances in plastics, bioplastics, and smart materials in the auto industry. Plastic role in design, safety, and sustainability in the auto industry. Recycling and the circular economy of …

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Stew News, March 2024, University Of Dayton. Rivers Institute Mar 2024

Stew News, March 2024, University Of Dayton. Rivers Institute

Stew News: The Newsletter of the University of Dayton River Stewards

No abstract provided.

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Litigation Landmines: Exclusionary Zoning And Sober Living Homes, Rachel L. Andersen Mar 2024

Litigation Landmines: Exclusionary Zoning And Sober Living Homes, Rachel L. Andersen

Marquette Benefits and Social Welfare Law Review

This article delves into the intricate landscape of sober living home ordinances within residential zoning districts, shedding light on exclusionary restrictions and requirements that have triggered extensive and costly discrimination litigation. Providing a concise history of the origins of modern-day sober living homes, the article examines legislative initiatives and ongoing litigation concerning zoning ordinances aimed at regulating these homes in residential neighborhoods. It explores the nuanced use or prohibition of specific terms and conditions within such ordinances and compares historical interpretations of regulatory provisions for recovery residences. The article presents examples of contentious terms and requirements that have fueled litigation, …

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Dna-Pkcs Rnaseq Data: Dna-Pkcs Wilde-Type Or Kinase-Dead Protein Regulate Basal And Etoposide-Induced Gene Expression Changes, Amanda Ashley Mar 2024

Dna-Pkcs Rnaseq Data: Dna-Pkcs Wilde-Type Or Kinase-Dead Protein Regulate Basal And Etoposide-Induced Gene Expression Changes, Amanda Ashley

Chemistry & Biochemistry: Datasets

No abstract provided.

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Automated Tree Mortality Detection Using Ubiquitously Available Public Data, Michael T. Huggins Mar 2024

Automated Tree Mortality Detection Using Ubiquitously Available Public Data, Michael T. Huggins

Master's Theses

Understanding the dynamic interplay between fire severity, topography, and tree mortality, is crucial for predicting future forest dynamics and enhancing resilience against climate change-induced wildfire regimes. This thesis develops a multi-sensor approach for automated estimation of tree mortality, then applies it to examine trends in tree mortality over a six-year period across a fire affected study site in the Trinity River basin in Northern California. The Random Forest model uses publicly available USGS 3D Elevation Program Lidar (3DEP) and NAIP imagery as inputs and is likely to be easily adaptable to other landscapes. The model had a Receiver Operating Characteristic …

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Facile One-Pot Synthesis And Anti-Microbial Activity Of Novel 1,4-Dihydropyridine Derivatives In Aqueous Micellar Solution Under Microwave Irradiation, Asmita Goswami, Navneet Kaur, Manvinder Kaur, Kishanpal Singh, Harvinder Singh Sohal, Haesook Han, Pradip K. Bhowmik Mar 2024

Facile One-Pot Synthesis And Anti-Microbial Activity Of Novel 1,4-Dihydropyridine Derivatives In Aqueous Micellar Solution Under Microwave Irradiation, Asmita Goswami, Navneet Kaur, Manvinder Kaur, Kishanpal Singh, Harvinder Singh Sohal, Haesook Han, Pradip K. Bhowmik

Chemistry and Biochemistry Faculty Research

The current study describes a novel and eco-conscious method to synthesize 1,4-dihydropyridine derivatives utilizing an aqueous micellar solution containing aluminum dodecyl sulfate, Al(DS)3, using readily available starting material. The final products were synthesized with excellent yields within remarkably quick reaction durations, promoting remarkable atom economy and minimizing environmental impacts. The present protocol has several advantages over other methodologies in terms of high yield (up to 97%) with excellent purity. Further, the synthesized 1,4-DHPs exhibit favorable to excellent resistance against examined bacterial and fungal species. Intriguingly, polar groups on the phenyl ring (5b, 5c, 5i and 5j) make the 1,4-DHPs equally …

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Fisheries Occasional Publication No.146 - Yabbie Aquaculture In Western Australia, March 2024, Department Of Primary Industries And Regional Development, Western Australia Mar 2024

Fisheries Occasional Publication No.146 - Yabbie Aquaculture In Western Australia, March 2024, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Occasional Publications

Policy relating to the assessment of yabbie aquaculture proposals and principles for assessment

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Sanctioning Mutilation: The Impact Of North Carolina’S Medical Necessity Exception To Its Statute On Female Genital Mutilation On Intersex Children, Xavier Dyer Mar 2024

Sanctioning Mutilation: The Impact Of North Carolina’S Medical Necessity Exception To Its Statute On Female Genital Mutilation On Intersex Children, Xavier Dyer

North Carolina Law Review

No abstract provided.

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Highly Sensitive On-Chip Grating-Based Optical Sensor On Glass Substrate: Cost-Effective Design, Hesham A. Attia, Mulan E. Ahmed, Adel Shaaban Awad Elsharkawi, Mohamed A. Swillam Mar 2024

Highly Sensitive On-Chip Grating-Based Optical Sensor On Glass Substrate: Cost-Effective Design, Hesham A. Attia, Mulan E. Ahmed, Adel Shaaban Awad Elsharkawi, Mohamed A. Swillam

Faculty Journal Articles

This paper presents a novel on-chip optical sensing system using ion exchange technology and phase-shifted Bragg grating design. The sensor geometry has been optimized using a finite difference time domain (FDTD) solver to achieve maximum sensitivity and figure of merit (FOM). The proposed design offers high sensitivity to changes in refractive index and low fabrication costs. The ion exchange process used to create the sensor allows for precise refractive index control, optimizing the sensor’s sensitivity and FOM. A graded-index waveguide and a phase-shifted Bragg grating structure also contribute to the sensor’s high sensitivity. The proposed sensor design was tested for …

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Doing Things With The Language Of Law And Gender: Using Speech Act Theory To Understand The Meaning And Effect Of The Gender Identity Backlash, Susan Etta Keller Mar 2024

Doing Things With The Language Of Law And Gender: Using Speech Act Theory To Understand The Meaning And Effect Of The Gender Identity Backlash, Susan Etta Keller

Nevada Law Journal

A significant legal backlash against transgender individuals is currently under way. This movement--which includes state legislation, state executive action, and federal cases--seeks to limit access and participation by transgender individuals in school sports, use of bathrooms, access to appropriate care, and even the right to be addressed appropriately in the classroom. Properly understood as a political backlash in response to previous political gains by transgender individuals, this movement is composed of a series of speech acts: language that makes change in the world and alters human relations. This article identifies the features of the backlash and the power dynamics that …

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Integrating Eod And Readiness Competencies Into The Ce Cgo Competency Framework, Kristina L. Johnson Mar 2024

Integrating Eod And Readiness Competencies Into The Ce Cgo Competency Framework, Kristina L. Johnson

Theses and Dissertations

In the last few years, the strategic focus of the United States defense posturing has shifted from legacy conflict in the Middle East to focusing on the Pacific with increased emphasis that Airmen must be educated and trained to deter or prevail in any conflict. To achieve this goal, the Department of Air Force (DAF) has evolved to utilizing a competency-based education framework with the Civil Engineer career field adopting this strategy and releasing the first version of their occupational competencies in 2020. However, DAF force posturing has evolved since 2020. With the new deployment system, Agile Combat Employment scheme …

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Measuring The Menu, Not The Food: “Psychometric” Data May Instead Measure “Lingometrics” (And Miss Its Greatest Potential), Jan Ketil Arnulf, Ulf Henning Olsson, Kim Nimon Mar 2024

Measuring The Menu, Not The Food: “Psychometric” Data May Instead Measure “Lingometrics” (And Miss Its Greatest Potential), Jan Ketil Arnulf, Ulf Henning Olsson, Kim Nimon

Human Resource Development Faculty Publications and Presentations

This is a review of a range of empirical studies that use digital text algorithms to predict and model response patterns from humans to Likert-scale items, using texts only as inputs. The studies show that statistics used in construct validation is predictable on sample and individual levels, that this happens across languages and cultures, and that the relationship between variables are often semantic instead of empirical. That is, the relationships among variables are given a priori and evidently computable as such. We explain this by replacing the idea of “nomological networks” with “semantic networks” to designate computable relationships between abstract …

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A Socio-Ecological Approach To A Community-Based Health Promotion Intervention On The U.S.-Mexico Border: Insights And Lessons Learned During The Covid-19 Pandemic, Yok-Fong Paat, Elizabeth Camacho, Sarah L. Ruiz, Diego Garcia Tovar, Guillermina Gina Núñez-Mchiri, Maria O. Duarte-Gardea, Guadalupe Corral, Sandra Oviedo Ramirez, Christine Markham, Luis R. Torres-Hostos Mar 2024

A Socio-Ecological Approach To A Community-Based Health Promotion Intervention On The U.S.-Mexico Border: Insights And Lessons Learned During The Covid-19 Pandemic, Yok-Fong Paat, Elizabeth Camacho, Sarah L. Ruiz, Diego Garcia Tovar, Guillermina Gina Núñez-Mchiri, Maria O. Duarte-Gardea, Guadalupe Corral, Sandra Oviedo Ramirez, Christine Markham, Luis R. Torres-Hostos

School of Social Work Faculty Publications

The Healthy Families Healthy Kids Initiative (HFHKI) is a community-based initiative developed based on the socio-ecological model to address preventive health care needs in El Paso County, Texas, one of the most economically and health-challenged border communities in the United States. HFHKI’s three main goals are to increase access to experiential learning and health education, service delivery, and sustainable systems/linkages of care. These were accomplished through seven critical activities. We present the rationale, background, setting, and conceptual framework for the initiative, followed by the methods used to develop and assess the success of the activities and results of our project …

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Gestural Temporality In Sciarrino’S Recitativo, Antares L. Boyle Mar 2024

Gestural Temporality In Sciarrino’S Recitativo, Antares L. Boyle

School of Music + Theater Faculty Publications and Presentations

Sciarrino’s writings describe a compositional philosophy that prizes multidimensionality and spatiotemporal discontinuity (1998, 2004). Yet his simultaneous allegiance to teleology, holism, and fractal hierarchies reveals an underlying unifying organicism with which these qualities may initially seem to conflict. I take Sciarrino’s 1999 piano concerto Recitativo oscuro as a case study for examining the composer’s gestural organicism and its various contradictions and double meanings. First, close analysis of the opening piano solo demonstrates how seemingly contradictory aesthetic priorities—organic unity and temporal multiplicity—co-exist within a single passage. Drawing from Kramer’s (1988) concept of “gestural time,” Hatten’s (2004) theory of gesture, segmentation theories, …

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Claudin-1 As A Novel Target Gene Induced In Obesity And Associated To Inflammation, Fibrosis, And Cell Differentiation, Pablo Fernández-García, Siri D. Taxerås, Marjorie Reyes-Farias, Lorena González, Andrea Soria-Gondek, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Jacqueline M. Stephens, Lindsey G. Yoo, María Galán, Adriana Izquierdo, Gema Medina-Gómez, Laura Herrero, Patricia Corrales, Francesc Villarroya, Rubén Cereijo, David Sánchez-Infantes Mar 2024

Claudin-1 As A Novel Target Gene Induced In Obesity And Associated To Inflammation, Fibrosis, And Cell Differentiation, Pablo Fernández-García, Siri D. Taxerås, Marjorie Reyes-Farias, Lorena González, Andrea Soria-Gondek, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Jacqueline M. Stephens, Lindsey G. Yoo, María Galán, Adriana Izquierdo, Gema Medina-Gómez, Laura Herrero, Patricia Corrales, Francesc Villarroya, Rubén Cereijo, David Sánchez-Infantes

Division of Basic Science Faculty Publications

Objective: T lymphocytes from visceral and subcutaneous white adipose tissues (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused on this subject. Claudin-1 (CLDN1) is a protein involved canonically in tight junctions and tissue paracellular permeability. We evaluated T-lymphocyte gene expression in vWAT and sWAT and in the whole adipose depots in human samples. Methods: A Clariom D-based transcriptomic analysis was performed on T lymphocytes magnetically separated from vWAT and sWAT from patients with obesity (Cohort 1; N = 11). Expression of candidate genes resulting from that analysis …

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Do Nitrogen And Phosphorus Influence Channel Catfish Growth In A Great Plains River?, Camden E. Oathout, Mark A. Pegg Mar 2024

Do Nitrogen And Phosphorus Influence Channel Catfish Growth In A Great Plains River?, Camden E. Oathout, Mark A. Pegg

International Journal of Undergraduate Research and Creative Activities

Evaluating abiotic environmental factors that influence growth of sportfish is key to understanding population dynamics and making appropriate management decisions. This is especially true in river systems where primary and secondary productivity can vary across temporal and spatial scales. In this study, we assessed fish responses to ambient nutrient levels (total nitrogen and total phosphorus) using growth rates determined from age-1 Channel Catfish, Ictalurus punctatus, in Platte River, Nebraska. Water quality and growth data were collected from sites across the central and lower Platte River from 2007 to 2013. We analyzed Platte River water quality data to find yearly average …

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Considering Returns On Federal Investment In The Negotiated “Maximum Fair Price” Of Drugs Under The Inflation Reduction Act: An Analysis, Edward W. Zhou, Paula G. Chaves Da Silva, Debbie Quijada, Fred D. Ledley Mar 2024

Considering Returns On Federal Investment In The Negotiated “Maximum Fair Price” Of Drugs Under The Inflation Reduction Act: An Analysis, Edward W. Zhou, Paula G. Chaves Da Silva, Debbie Quijada, Fred D. Ledley

Natural & Applied Sciences Faculty Publications

The Inflation Reduction Act (IRA) of 2022 contained landmark provisions authorizing government to negotiate a “maximum fair price” for selected Medicare Part D drugs considering the manufacturer’s research and development costs, federal support for discovery and development, the extent to which the drugs address unmet medical needs, and other factors. This working paper describes federal investment in the discovery and development of the ten drugs selected for price negotiation in the first year of the IRA as well as the health value created through Medicare Part D spending on these drugs. We identified $11.7 billion in NIH funding for basic …

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Worldwide Forest Surveys Reveal Forty-Three New Species In Phytophthora Major Clade 2 With Fundamental Implications For The Evolution And Biogeography Of The Genus And Global Plant Biosecurity, T. Jung, I. Milenković, Y. Balci, J. Janoušek, T. Kudláček, Z. Nagy, B. Baharuddin, J. Bakonyi, K. D. Broders, S. O. Cacciola, T. T. Chang, N. M. Chi, T. Corcobado, A. Cravador, B. Dordević, A. Durán, M. Ferreira, C. H. Fu, L. Garcia, A. Hieno, H. H. Ho, C. Hong, M. Junaid, K. Kageyama, T. Kuswinanti, C. Maia, T. Májek, H. Masuya, G. Magnano Di San Lio, B. Mendieta-Araica, N. Nasri, L. S.S. Oliveira, A. Pane Mar 2024

Worldwide Forest Surveys Reveal Forty-Three New Species In Phytophthora Major Clade 2 With Fundamental Implications For The Evolution And Biogeography Of The Genus And Global Plant Biosecurity, T. Jung, I. Milenković, Y. Balci, J. Janoušek, T. Kudláček, Z. Nagy, B. Baharuddin, J. Bakonyi, K. D. Broders, S. O. Cacciola, T. T. Chang, N. M. Chi, T. Corcobado, A. Cravador, B. Dordević, A. Durán, M. Ferreira, C. H. Fu, L. Garcia, A. Hieno, H. H. Ho, C. Hong, M. Junaid, K. Kageyama, T. Kuswinanti, C. Maia, T. Májek, H. Masuya, G. Magnano Di San Lio, B. Mendieta-Araica, N. Nasri, L. S.S. Oliveira, A. Pane

Faculty Publications

During 25 surveys of global Phytophthora diversity, conducted between 1998 and 2020, 43 new species were detected in natural ecosystems and, occasionally, in nurseries and outplantings in Europe, Southeast and East Asia and the Americas. Based on a multigene phylogeny of nine nuclear and four mitochondrial gene regions they were assigned to five of the six known subclades, 2a-c, e and f, of Phytophthora major Clade 2 and the new subclade 2g. The evolutionary history of the Clade appears to have involved the pre-Gondwanan divergence of three extant subclades, 2c, 2e and 2f, all having disjunct natural distributions on separate …

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Influence Of Hesperidin On The Physico-Chemical, Microbiological And Sensory Characteristics Of Frozen Yogurt †, Roberto Cedillos, Ricardo S. Aleman, Ryan Page, Douglas W. Olson, Charles Boeneke, Witoon Prinyawiwatkul, Kayanush Aryana Mar 2024

Influence Of Hesperidin On The Physico-Chemical, Microbiological And Sensory Characteristics Of Frozen Yogurt †, Roberto Cedillos, Ricardo S. Aleman, Ryan Page, Douglas W. Olson, Charles Boeneke, Witoon Prinyawiwatkul, Kayanush Aryana

Faculty Publications

Frozen yogurts contain yogurt culture bacteria, which might impart health benefits to their consumers. Global frozen yogurt market sales are expected to grow by 4.8% by 2028, which represents an important opportunity for the industry, consumers and researchers. Polyphenols are metabolites found in plants which have antioxidant and anti-inflammatory properties and might prevent chronic diseases such as cancer, diabetes and cardiovascular diseases. The objective of this study was to elucidate the effect of the polyphenol hesperidin on the physico-chemical, microbiological and sensory characteristics of frozen yogurts. Hesperidin was incorporated into frozen yogurt at three concentrations (125, 250 and 500 mg/90 …

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Seven-Year Prospective Study On Yearly Incidence Of Orbivirus Infection Of Captive White-Tailed Deer And Potential Culicoides Vectors, Michael Becker, Glen Gentry, Claudia Husseneder, Lane Foil Mar 2024

Seven-Year Prospective Study On Yearly Incidence Of Orbivirus Infection Of Captive White-Tailed Deer And Potential Culicoides Vectors, Michael Becker, Glen Gentry, Claudia Husseneder, Lane Foil

Faculty Publications

Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) are arthropod-borne viruses that are transmitted by biting midges in the genus Culicoides (Diptera: Ceratopogonidae) and can cause hemorrhagic disease in certain ruminants. The objectives of this study were to measure the incidence of BTV and EHDV infections in captive white-tailed deer herd as well as tissues and corresponding presence of Culicoides midges at a location near Clinton, LA. During a 7-yr study with yearly outbreaks of hemorrhagic disease in the deer herd, 15 species of Culicoides were captured using Centers for Disease Control (CDC) black light traps. Reverse transcriptase quantitative …

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Two-Pore Potassium Channel Trek-1 (K2p2.1) Regulates Nlrp3 Inflammasome Activity In Macrophages, Camille N. Immanuel, Bin Teng, Brittany E. Dong, Elizabeth M. Gordon, Charlean Luellen, Benjamin Lopez, Jeffrey Harding, Stephania A. Cormier, Elizabeth A. Fitzpatrick, Andreas Schwingshackl, Christopher M. Waters Mar 2024

Two-Pore Potassium Channel Trek-1 (K2p2.1) Regulates Nlrp3 Inflammasome Activity In Macrophages, Camille N. Immanuel, Bin Teng, Brittany E. Dong, Elizabeth M. Gordon, Charlean Luellen, Benjamin Lopez, Jeffrey Harding, Stephania A. Cormier, Elizabeth A. Fitzpatrick, Andreas Schwingshackl, Christopher M. Waters

Division of Basic Science Faculty Publications

Because of the importance of potassium efflux in inflammasome activation, we investigated the role of the two-pore potassium (K2P) channel TREK-1 in macrophage inflammasome activity. Using primary alveolar macrophages (AMs) and bone marrow-derived macrophages (BMDMs) from wild-type (wt) and TREK-1–/– mice, we measured responses to inflammasome priming [using lipopolysaccharide (LPS)] and activation (LPS þ ATP). We measured IL-1b, caspase-1, and NLRP3 via ELISA and Western blot. A membrane-permeable potassium indicator was used to measure potassium efflux during ATP exposure, and a fluorescence-based assay was used to assess changes in membrane potential. Inflammasome activation induced by LPS þ ATP increased IL-1b …

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An Island ‘Endemic’ Born Out Of Hybridization Between Introduced Lineages, Jessie F. Salter, Robb T. Brumfield, Brant C. Faircloth Mar 2024

An Island ‘Endemic’ Born Out Of Hybridization Between Introduced Lineages, Jessie F. Salter, Robb T. Brumfield, Brant C. Faircloth

Faculty Publications

Humans have profoundly impacted the distribution of plant and animal species over thousands of years. The most direct example of these effects is human-mediated movement of individuals, either through translocation of individuals within their range or through the introduction of species to new habitats. While human involvement may be suspected in species with obvious range disjunctions, it can be difficult to detect natural versus human-mediated dispersal events for populations at the edge of a species' range, and this uncertainty muddles how we understand the evolutionary history of populations and broad biogeographical patterns. Studies combining genetic data with archaeological, linguistic and …

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The Expected Behaviors Of Posterior Predictive Tests And Their Unexpected Interpretation, Luiza Guimarães Fabreti, Lyndon M. Coghill, Robert C. Thomson, Sebastian Höhna, Jeremy M. Brown Mar 2024

The Expected Behaviors Of Posterior Predictive Tests And Their Unexpected Interpretation, Luiza Guimarães Fabreti, Lyndon M. Coghill, Robert C. Thomson, Sebastian Höhna, Jeremy M. Brown

Faculty Publications

Poor fit between models of sequence or trait evolution and empirical data is known to cause biases and lead to spurious conclusions about evolutionary patterns and processes. Bayesian posterior prediction is a flexible and intuitive approach for detecting such cases of poor fit. However, the expected behavior of posterior predictive tests has never been characterized for evolutionary models, which is critical for their proper interpretation. Here, we show that the expected distribution of posterior predictive P-values is generally not uniform, in contrast to frequentist P-values used for hypothesis testing, and extreme posterior predictive P-values often provide more evidence of poor …

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Identification Of A Chondrocyte-Specific Enhancer In The Hoxc8 Gene, Stephania A. Cormier, Claudia Kappen Mar 2024

Identification Of A Chondrocyte-Specific Enhancer In The Hoxc8 Gene, Stephania A. Cormier, Claudia Kappen

Division of Basic Science Faculty Publications

Hox genes encode transcription factors whose roles in patterning animal body plans during embryonic development are well-documented. Multiple studies demonstrate that Hox genes continue to act in adult cells, in normal differentiation, in regenerative processes, and, with abnormal expression, in diverse types of cancers. However, surprisingly little is known about the regulatory mechanisms that govern Hox gene expression in specific cell types, as they differentiate during late embryonic development, and in the adult organism. The murine Hoxc8 gene determines the identity of multiple skeletal elements in the lower thoracic and lumbar region and continues to play a role in the …

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Genome-Wide Polygenic Risk Score For Ckd In Individuals With Apol1 High-Risk Genotypes, Ha My T. Vy, Steven G. Coca, Ashwin Sawant, Ankit Sakhuja, Orlando M. Gutierrez, Richard Cooper, Ruth J.F. Loos, Carol R. Horowitz, Ron Do, Girish N. Nadkarni Mar 2024

Genome-Wide Polygenic Risk Score For Ckd In Individuals With Apol1 High-Risk Genotypes, Ha My T. Vy, Steven G. Coca, Ashwin Sawant, Ankit Sakhuja, Orlando M. Gutierrez, Richard Cooper, Ruth J.F. Loos, Carol R. Horowitz, Ron Do, Girish N. Nadkarni

Faculty Publications

No abstract provided.

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Coastal Wetland Restoration Through The Lens Of Odum's Theory Of Ecosystem Development, Friedrich W. Keppeler, Annette S. Engel, Linda M. Hooper-Bùi, Paola C. López-Duarte, Charles W. Martin, Jill A. Olin, Katelyn J. Lamb, Michael J. Polito, Nancy N. Rabalais, Brian J. Roberts, Erick M. Swenson, Olaf P. Jensen Mar 2024

Coastal Wetland Restoration Through The Lens Of Odum's Theory Of Ecosystem Development, Friedrich W. Keppeler, Annette S. Engel, Linda M. Hooper-Bùi, Paola C. López-Duarte, Charles W. Martin, Jill A. Olin, Katelyn J. Lamb, Michael J. Polito, Nancy N. Rabalais, Brian J. Roberts, Erick M. Swenson, Olaf P. Jensen

Faculty Publications

Advancing ecological restoration assessments requires a more detailed consideration of species interactions and ecosystem processes. Most restoration projects rely on a few metrics not always directly linked with ecological theory. Here, we used Odum's theory of ecosystem development to assess and compare the ecosystem structure and services of created marshes (4–6 years old) with preexisting, reference marshes in a brackish water region of the Mississippi River Delta. We built ecosystem models for created and reference marshes that integrated large datasets of stomach contents, stable isotopes, and taxa abundances. Despite strong resemblance in community structure, created marshes were at an earlier …

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Artifactual Orthologs And The Need For Diligent Data Exploration In Complex Phylogenomic Datasets: A Museomic Case Study From The Andean Flora, Laura A. Frost, Ana M. Bedoya, Laura P. Lagomarsino Mar 2024

Artifactual Orthologs And The Need For Diligent Data Exploration In Complex Phylogenomic Datasets: A Museomic Case Study From The Andean Flora, Laura A. Frost, Ana M. Bedoya, Laura P. Lagomarsino

Faculty Publications

The Andes mountains of western South America are a globally important biodiversity hotspot, yet there is a paucity of resolved phylogenies for plant clades from this region. Filling an important gap in our understanding of the World's richest flora, we present the first phylogeny of Freziera (Pentaphylacaceae), an Andean-centered, cloud forest radiation. Our dataset was obtained via hybrid-enriched target sequence capture of Angiosperms353 universal loci for 50 of the ca. 75 spp., obtained almost entirely from herbarium specimens. We identify high phylogenomic complexity in Freziera, including the presence of data artifacts. Via by-eye observation of gene trees, detailed examination of …

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