Digital Commons Network^™

Selective Vapor Condensation For The Synthesis And Assembly Of Spherical Colloids With A Precise Rough Patch, Kennedy A. Guillot, Philip J. Brahana, Ahmed Al Harraq, Nduka D. Ogbonna, Nicholas S. Lombardo, Jimmy Lawrence, Yaxin An, Michael G. Benton, Bhuvnesh Bharti

Faculty Publications

Patchy particles occupy an increasingly important space in soft matter research due to their ability to assemble into intricate phases and states. Being able to fine-tune the interactions among these particles is essential to understanding the principles governing the self-assembly processes. However, current fabrication techniques often yield patches that deviate chemically and physically from the native particles, impeding the identification of the driving forces behind self-assembly. To overcome this challenge, we propose a new approach to synthesizing spherical colloids with a well-defined rough patch on their surface. By treating polystyrene microspheres with vapors of a good solvent, here an acetone-water …

Can Machine Learning Models Provide Accurate Fertilizer Recommendations?, Takashi S. T. Tanaka, Gerard B. M. Heuvelink, Taro Mieno, David S. Bullock

Department of Agricultural Economics: Faculty Publications

Accurate modeling of site-specific crop yield response is key to providing farmers with accurate site-specific economically optimal input rates (EOIRs) recommendations. Many studies have demonstrated that machine learning models can accurately predict yield. These models have also been used to analyze the effect of fertilizer application rates on yield and derive EOIRs. But models with accurate yield prediction can still provide highly inaccurate input application recommendations. This study quantified the uncertainty generated when using machine learning methods to model the effect of fertilizer application on site-specific crop yield response. The study uses real on-farm precision experimental data to evaluate the …

03.25.2024 Orsp Connect, Liz Williamson

ORED Newsletter

Cammi Thornton, Compliance Training Requirements

Outcomes For Individuals Born Outside Of Marriage, Kathryn Dawn Keithley

Theses and Dissertations

This paper examines the effect of being born outside of marriage (BOOM) on the future outcomes of individuals. I use the Panel Study of Income Dynamics (PSID) individual-level data to follow individuals from birth to age 30 and analyze the effect of being born outside of marriage on future marital status, education level, and poverty status. I find statistically significant impacts of BOOM on future outcomes, though additional childhood controls lessen the effect. I then use arguably exogenous variation from the marital status of an individual’s grandmother at the time of their mother’s birth to instrument for external factors that …

Assessment Of Pollution Sources For The Lake Burullus Influent Drains At The North Of Egypt, Aya Hassan

Civil Engineering

Assessment of Pollution Sources for the Lake Burullus Influent Drains at the North of Egypt. Egyptian northern region is facing significant pollution issues due to various factors such as fish farming expansion, industrial activities, and agricultural drainage water that enters the lake from the north through different drains. This pollution has detrimental effects on the lake's ecology and economy. The main goal of this study is to assess the current state of the influent drains into the Lake Burullus, that represent the second largest lake in the northern lakes of Egyptian. The water quality parameters in the influent drains to …

Consensus Pharmacophore Strategy For Identifying Novel Sars-Cov-2 Mpro Inhibitors From Large Chemical Libraries, Angel J Ruiz-Moreno, Raziel Cedillo-González, Luis Cordova-Bahena, Zhiqiang An, José L Medina-Franco, Marco A Velasco-Velázquez

The Brown Foundation: Institute of Molecular Medicine

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main Protease (Mpro) is an enzyme that cleaves viral polyproteins translated from the viral genome and is critical for viral replication. Mpro is a target for anti-SARS-CoV-2 drug development, and multiple Mpro crystals complexed with competitive inhibitors have been reported. In this study, we aimed to develop an Mpro consensus pharmacophore as a tool to expand the search for inhibitors. We generated a consensus model by aligning and summarizing pharmacophoric points from 152 bioactive conformers of SARS-CoV-2 Mpro inhibitors. Validation against a library of conformers from a subset of ligands showed that …

Mediation Between States And Criminal Defendants For Post-Conviction Relief Under State Dna Statutes, Nowshin Nawal

Cardozo Journal of Conflict Resolution (CJCR) Blog

With new advances in DNA technology, it has become easier to use DNA testing to find perpetrators of crime where DNA evidence is present. Many incarcerated individuals claiming innocence seek to have the evidence tested during post-conviction in light of new technology. Forty-seven states now have DNA statutes that allow testing during the post-conviction stage. A new problem arises because state prosecutors are often reluctant to agree to DNA testing, which leaves litigation as the remaining method—which is inefficient. The process would be more efficient if a third party worked with the state and the defendant.

This post was originally …

Identification Of Nonfunctional Alternatively Spliced Isoforms Of Sting In Human Acute Myeloid Leukemia, Akash R Boda, Arthur J Liu, Susana Castro-Pando, Benjamin T Whitfield, Jeffrey J Molldrem, Gheath Al-Atrash, Maria Emilia Di Francesco, Philip Jones, Casey R Ager, Michael A Curran

Faculty, Staff and Student Publications

UNLABELLED: Lack of robust activation of Stimulator of Interferon Genes (STING) pathway and subsequent induction of type I IFN responses is considered a barrier to antitumor immunity in acute myeloid leukemia (AML). Using common human AML cell lines as in vitro tools to evaluate the efficacy of novel STING agonists, we found most AML lines to be poor producers of IFNs upon exposure to extremely potent agonists, suggesting cell-intrinsic suppression of STING signaling may occur. We observed unexpected patterns of response that did not correlate with levels of STING pathway components or of known enzymes associated with resistance. To identify …

Altered Lipid Metabolism In Apc-Driven Colorectal Cancer: The Potential For Therapeutic Intervention, Courtney O. Kelson, Yekaterina Y. Zaytseva

Markey Cancer Center Faculty Publications

Altered lipid metabolism is a well-recognized feature of solid cancers, including colorectal cancer. In colorectal cancer, upregulation of lipid metabolism contributes to initiation, progression, and metastasis; thus, aberrant lipid metabolism contributes to a poor patient outcome. The inactivating mutation of APC, a vital tumor suppressor in the Wnt signaling pathway, is a key event that occurs early in the majority of colorectal cancer cases. The potential crosstalk between lipid metabolism and APC-driven colorectal cancer is poorly understood. This review collectively highlights and summarizes the limited understanding between mutations in APC and the upregulation of Wnt/beta- catenin signaling and lipid metabolism. …

Dissociating Reading And Auditory Comprehension In Persons With Aphasia, Rachael M. Harrington, Sigfus Kristinsson, Janina Wilmskoetter, Natalie Busby, Dirk B. Den Ouden, Chris Rorden, Julius Fridriksson, Leonardo Bonilha

Communication Sciences and Disorders Faculty Articles and Research

Language comprehension is often affected in individuals with post-stroke aphasia. However, deficits in auditory comprehension are not fully correlated with deficits in reading comprehension and the mechanisms underlying this dissociation remain unclear. This distinction is important for understanding language mechanisms, predicting long-term impairments and future development of treatment interventions. Using comprehensive auditory and reading measures from a large cohort of individuals with aphasia, we evaluated the relationship between aphasia type and reading comprehension impairments, the relationship between auditory versus reading comprehension deficits and the crucial neuroanatomy supporting the dissociation between post-stroke reading and auditory deficits. Scores from the Western Aphasia …

Favorable Factors In Methane Production From Residual Coal Post-Biohydrogen Generation, Xia Daping, Liao Jiajia, Chen Zhenhong, Chen Xi, Guo Hongyu, Huang Dan

Coal Geology & Exploration

Determining favorable factors in methane production from residual coal post-biohydrogen production holds great theoretical and practical significance for improving the efficiency of methane production in the second stage of coal-based poly-generation. This study focuses on residual coal after hydrogen generation through anaerobic fermentation. Using coal samples from the Baiyinhua open-pit mine in Inner Mongolia as fermentation substrates, this study explored the dynamic trends of both the methane production and structure of the residual coal under different conditions by altering the aeration conditions and hydraulic retention time (HRT). Key findings are as follows: (1) Among the experiment groups with different atmosphere …

The Effect Of Teacher Identity On The Level Of Cultural Inclusion In The Classroom, Jennifer Jones

Dissertations

The purpose of this qualitative phenomenographical study was to investigate high school teachers’ perceptions of cultural inclusion and the impact of teacher identity on the level of cultural inclusion in the classroom. This research study utilized semi-structured one-on-one interviews as the primary source of data and participant surveys and researcher notes taken during the interviews as the secondary sources. This study sought to address two research questions: (1) What can we learn from teachers' experiences at a southeastern suburban high school regarding the post-COVID perceptions of cultural inclusion in the classroom? (2) How does teacher identity affect cultural inclusion in …

An Analysis Of Florida Manatee (Trichechus Manatus Latirostris) Rescues (1993-2022) With Recommendations For Future Rehabilitation Program Needs, Katherine Frisch

USF Tampa Graduate Theses and Dissertations

Florida manatees (Trichechus manatus latirostris) are threatened marine mammals that inhabit the coastal and near shore waters along the southeastern United States, primarily Florida. Manatee conservation is multi-faceted. One component of the manatee recovery program is the rescue and rehabilitation program that provides care for sick, injured and orphaned manatees. The science of conservation biology, whose goal is to maintain biodiversity using a multidisciplinary approach, can be applied to aspects of the manatee rescue and rehabilitation program.

A federally authorized, state implemented, rescue system has been in place for many years to rescue and treat injured and orphaned animals. Rescued …

Interfacial Magnetism And Anisotropy In Dirac And Weyl Semimetals, Noah Schulz

USF Tampa Graduate Theses and Dissertations

Semimetals have gained intense interest recently due to their exotic magnetic and electronic properties. One of the most widely studied semimetals is graphene, a Dirac semimetal. The utilization of graphene in devices and sensors requires interfacing it with other materials, which may induce potentially strong interfacial effects. Furthermore, graphene alone does not possess magnetic order. Studying the interfacial effects between graphene and magnetic materials is therefore of great importance in the application of graphene to meet modern technological needs. Furthermore, by understanding the fundamental interfacial physics between graphene and magnetic materials, new properties can be unlocked, broadening the possible applications …

Perceptions Of Stakeholders On The Threats And Impacts To The Seascape Of Mauritius, Sarah Heaton, John Martin, Karen Woomed

Professional Services

The seascapes of Small Island Developing States are at risk from anthropogenic pollution. To implement effective seascape management, there is a need to better understand the threats to the seascape, subsequent impacts and associated stakeholder perceptions. This study used a systematic literature review, online survey and follow-up interviews to identify the main threats and impacts to the seascape and analyze associated perceptions of stakeholders, using Mauritius as a case study. The key threats were found to be oil spills, anthropogenic marine debris, coastal development, tourism, poor environmental management, and inadequate enforcement of legislation. Associated perception data showed a high awareness …

Tmem106b Coding Variant Is Protective And Deletion Detrimental In A Mouse Model Of Tauopathy, George A Edwards, Caleb A Wood, Yang He, Quynh Nguyen, Peter J Kim, Ruben Gomez-Gutierrez, Kyung-Won Park, Yong Xu, Cody Zurhellen, Ismael Al-Ramahi, Joanna L Jankowsky

Duncan NRI Faculty and Staff Publications

TMEM106B is a risk modifier of multiple neurological conditions, where a single coding variant and multiple non-coding SNPs influence the balance between susceptibility and resilience. Two key questions that emerge from past work are whether the lone T185S coding variant contributes to protection, and if the presence of TMEM106B is helpful or harmful in the context of disease. Here, we address both questions while expanding the scope of TMEM106B study from TDP-43 to models of tauopathy. We generated knockout mice with constitutive deletion of TMEM106B, alongside knock-in mice encoding the T186S knock-in mutation (equivalent to the human T185S variant), and …

Hazardous Explosive Eruptions Of A Recharging Multi-Cyclic Island Arc Caldera, Jonas Preine, Jens Karstens, Christian Hübscher, Tim Druitt, Steffen Kutterolf, Paraskevi Nomikou, Michael Manga, Ralf Gertisser, Katharina Pank, Sarah Beethe, Carole Berthod, Gareth Crutchley, Iona Mcintosh, Thomas Ronge, Masako Tominaga, Acacia Clark, Susan Debari, Raymond Johnston, Zenon Mateo, Ally Peccia, Christopher Jones, Günther Kletetschka, Abigail Metcalfe, Alexis Bernard, Hehe Chen, Shun Chiyonobu, Tatiana Fernandez-Perez, Kumar Batuk Joshi, Olga Koukousioura, Molly Mccanta, Antony Morris, Paraskevi Polymenakou, Adam Woodhouse, Yuzuru Yamamoto, Kuo Lung Wang, Hao Yang Lee, Xiaohui Li, Dimitrios Papanikolaou

School of Geography, Earth and Environmental Sciences

Caldera-forming eruptions of silicic volcanic systems are among the most devastating events on Earth. By contrast, post-collapse volcanic activity initiating new caldera cycles is generally considered less hazardous. Formed after Santorini’s latest caldera-forming eruption of ~1600 bce, the Kameni Volcano in the southern Aegean Sea enables the eruptive evolution of a recharging multi-cyclic caldera to be reconstructed. Kameni’s eruptive record has been documented by onshore products and historical descriptions of mainly effusive eruptions dating back to 197 bce. Here we combine high-resolution seismic reflection data with cored lithologies from International Ocean Discovery Program Expedition 398 at four sites to determine …

Extend The Benchmarking Indel Set By Manual Review Using The Individual Cell Line Sequencing Data From The Sequencing Quality Control 2 (Seqc2) Project, Binsheng Gong, Dan Li, Yifan Zhang, Rebecca Kusko, Samir Lababidi, Zehui Cao, Mingyang Chen, Ning Chen, Qiaochu Chen, Qingwang Chen, Jiacheng Dai, Qiang Gan, Yuechen Gao, Mingkun Guo, Gunjan Hariani, Yujie He, Wanwan Hou, He Jiang, Garima Kushwaha, Jian-Liang Li, Jianying Li, Yulan Li, Liang-Chun Liu, Ruimei Liu, Shiming Liu, Edwin Meriaux, Mengqing Mo, Mathew Moore, Tyler J Moss, Quanne Niu, Ananddeep Patel, Luyao Ren, Nedda F Saremi, Erfei Shang, Jun Shang, Ping Song, Siqi Sun, Brent J Urban, Danke Wang, Shangzi Wang, Zhining Wen, Xiangyi Xiong, Jingcheng Yang, Lihui Yin, Chao Zhang, Ruolan Zhang, Ambica Bhandari, Wanshi Cai, Agda Karina Eterovic, Dalila B Megherbi, Tieliu Shi, Chen Suo, Ying Yu, Yuanting Zheng, Natalia Novoradovskaya, Renee L Sears, Leming Shi, Wendell Jones, Weida Tong, Joshua Xu

Faculty, Staff and Student Publications

Accurate indel calling plays an important role in precision medicine. A benchmarking indel set is essential for thoroughly evaluating the indel calling performance of bioinformatics pipelines. A reference sample with a set of known-positive variants was developed in the FDA-led Sequencing Quality Control Phase 2 (SEQC2) project, but the known indels in the known-positive set were limited. This project sought to provide an enriched set of known indels that would be more translationally relevant by focusing on additional cancer related regions. A thorough manual review process completed by 42 reviewers, two advisors, and a judging panel of three researchers significantly …

Adolescent Algorithm Addiction, Canyon Skare

Honors Program: Senior Projects (Public)

There’s no question that online Social Networking Sites have contributed to the sharp decline in mental health among adolescents. This thesis explores a number of Addictive Online Behaviors that have contributed to negative mental health outcomes, namely examining at total screentime, level of engagement, and total number of accounts one has in relation to phone addiction and social media addiction. It was found that total screentime and total number of accounts were more strongly correlated with social media addiction than phone addiction. Additionally, differences in app usage among gender was explored, finding that boys favored YouTube and Discord while Girls …

Β-Cyclodextrin-Enzalutamide Self-Assembly Complexes For Prostate Cancer Therapy, Meghana Kolli, Rahul Tiwari, Subhash C. Chauhan, Yonghong Zhang, Neeraj Chauhan, Alba C. M, Murali Yallapu

Research Symposium

Background:Castrate circumstances brought on by therapy give rise to castrationresistant prostate cancer (CRPC), which thereafter develops androgen receptor (AR) resistance. AR inhibitors are frequently used to obstruct AR translocation in cells that overexpress AR and slow the progression of cancer by reducing the number of AR receptors that are accessible. In comparison to Bicalutamide, a first-generation AR inhibitor, the hydrophobic drug Enzalutamide has demonstrated higher effectiveness. We investigate Enzalutamide as a viable option for the formation of self-assembly complexes because AR downregulation is still the major treatment for CRPC.

Methods:Enz-loaded self-assembly complexes (enz-β-CD) formulation was developed using solvent …

Unraveling Sorafenib Resistance In Hepatocellular Carcinoma: Exploring Key Facets, Dennis Kwabiah, Kyle Doxtater, Yamile Abuchard, Sophia Leslie, Ricardo Pequeno Bracho, Shaibir Hussain, Manish K. Tripathi

Research Symposium

Hepatocellular carcinoma (HCC) stands as the prevalent form of primary liver cancer worldwide, diagnosing over half a million new cases annually. Surgical interventions like hepatectomy and liver transplantation offer a potential cure for early-stage HCC. However, the prognosis for advanced stages remains grim due to drug resistance, particularly with high refractoriness rates. Sorafenib, a tyrosine kinase inhibitor, is an approved treatment for advanced HCC. Despite its use, the overall survival extension for these patients remains limited due to the drug's ineffectiveness, and the mechanism behind advanced HCC's resistance to sorafenib remains elusive. TCGA analysis of HCC patient cohorts reveals elevated …

Ultrabithorax, Abdominal-A And Abdominal-B Form Heterodimers And Homodimers In Living Cells By Bifc, Rubén Montalvo Méndez, Gustavo Jiménez-Mejía, Diana Reséndez-Pérez

Research Symposium

Background: Hox genes encode transcriptional factors that regulate the expression of specific target genes along the anterior-posterior axis determining the segment identity during embryonic development. These master genes are expressed in the same order in which are located in the third chromosome of Drosophila melanogaster. As it was previously reported the interaction of neighboring Hox proteins as Scr-Antp and Antp-Ubx and one of the mechanisms for Hox protein regulation is protein-protein interaction, we determined the heterodimer formation of Ubx with AbdA and AbdB as well as the homodimer formation of these proteins in living cells which in turn could …

Trip13’S Crucial Role In Pancreatic Cancer Progression, Swati Dhasmana, Anupam Dhasmana, Stella Rios, Iris A. Enriquez-Perez, Sheema Khan, Farrukh Afaq, Upender Manne, Murali M. Yallapu, Subhash Chauhan

Research Symposium

Background: Pancreatic cancer, characterized by its high mortality rate, stands as one of the most aggressive cancer forms. The projected surge in pancreatic cancer-related deaths, making it the second leading cause in the United States by 2030, underscores the urgency for effective early screening tools. This study employs data mining methods to scrutinize bioinformatic data surrounding TRIP13. Examining differential expression across various cancers, correlating TRIP13 expression with pancreatic cancer stages, exploring associations with common cancer genes, and analyzing overall survival rates constitute the core investigations. Integrated with molecular biology techniques, the study further quantifies TRIP13 expression in progressive pancreatic cancer …

Trimeric Antp-Tbp Complexes With Tfiieβ And Exd Modulated The Transcriptional Activity Of Antp, Norma C. Hernández-Bautista, Claudia A. Altamirano-Torres, Ruben Montalvo Mendez, Gustavo Jiménez-Mejía, Diana Reséndez-Pérez

Research Symposium

Homeoproteins are transcription factors that bind to DNA through a highly conserved binding domain known as the homeodomain (HD), which recognizes short regions rich in A-T. This DNA binding triggers the modulation of multiple target genes responsible for identity in various structures along the A-P axis of D. melanogaster. However, the high similarity of homeodomains and their affinity for widely distributed sites in the genome poses the "Hox paradox," which seeks to explain how homeoproteins acquire functional specificity so precisely. Previous evidence shows that homeoproteins like Antennapedia (Antp) form dimers with cofactors and other transcription factors to modulate their …

The Role Of Oral Microbiota In Periodontitis And Alzheimer's Disease, Noah Al-Hassan, Taha Al Hassan, Juan C. Lopez-Alvarenga, Maria Quinones, Seratna Guadarrama

Research Symposium

Background: Periodontal disease (PD), affecting 20-50% of the global population is marked by biofilm-induced inflammation in oral tissues. Chronic PD results in systemic complications such as heart disease, stroke, and Alzheimer's. The red complex microbes, Porphyromonas gingivalis and Treponema denticola, play a pivotal role, penetrating the blood-brain barrier and contributing to neurodegeneration. Alzheimer's disease (AD), an irreversible neurodegenerative disorder, is linked to abnormal protein cleavage and potentially involves microbiologic components, including gram-positive cocci. Research suggests the presence of bacteria such as Porphyromonas, Actinomyces, and Treponema in autopsied AD brains. Investigating the microbiologic connection between PD and AD is crucial, considering …

The Role Of Age And Biological Sex On Short-Term Memory In The Syrian Hamster (Mesocricetus Auratus), Laura E. Garcia, Mario Gil

Research Symposium

Background: Aging plays an important role in cognitive function, memory, and mental health. As we age, some cognitive functions become weaker. Aging is also a critical risk factor for dementia and Alzheimer’s Disease. With recent advances seen in public health, humans are living longer years. This makes it a challenge to make those added years healthy. For this reason, it is important to continue studying its effects by using, the Syrian hamster, as a model. The purpose of the study is to identify other factors that might also have a role in short-term memory, besides aging.

Methods: All behavioral …

The Reality Of Psychological Preparation Among Jordanian National Teams For Individual Sports During The Coronavirus Outbreak, Ayed Zureigat, Osama Abdel Fattah

Jordan Journal of Applied Science-Humanities Series

This study aimed to identify the reality of psychological preparation among players of the Jordanian national teams for individual sports during the Coronavirus outbreak. Additionally, it sought to assess the levels of depression and anxiety among these players during the same period. To achieve this, a descriptive method was employed with a sample consisting of 54 participants. To minimize face-to-face interaction, an electronic questionnaire was created using Google Forms, containing 28 items addressing depression, anxiety, and psychological methods used with players. Of these items, 12 were related to depression and anxiety, while 16 were focused on psychological methods. To analyze …

Medical School Watercooler Newsletter - March 24, 2024, Lindsey Lyle

Watercooler Newsletter

This is the March 24, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• ODI Staff to discuss health disparities and equities
• Whiddon College of Medicine welcomes new associate dean for finance and administration
• Special OB-GYN grand rounds to focus on Black maternal mortality
• Meet a Med Student: Kramer Crider
• USA investigators identify potential biomarker for early pancreatic cancer diagnosis
• The Final Countdown: Doc Rock is Thursday Night
• DiPalma honored at 19th Annual Distinguished Alumni & Service Awards

The Chronicle, Kennedy Ballinger, Lara Jones, Dashae Engler, Bella Perez, Emily Riley, Riley Dickerson, Maya Pierce, Andy Langager

Campus Chronicle

No abstract provided.

Faculty Senate Meeting Agenda And Minutes, March 24, 2024

Faculty Senate Minutes and Agendas

Agenda and minutes from the Wright State University Faculty Senate Meeting held on, March 24, 2024.