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Ua-Rg08-01 School Of Nursing / Office Of The Dean, Archives

Archives Registers

Self-reports, course syllabi, committee notes, various surveys & reviews, correspondence, announcements, ceremony programs, procedures and policies, 1978-2011

Ua-Rg05-03 College Of Arts And Sciences / Biology, Archives

Archives Registers

Faculty publications, program offerings, flyers and brochures for various events/science fairs (1967-1986)

Ua-Rg05-01 College Of Arts And Sciences / Office Of The Dean, Archives

Archives Registers

Faculty publications, various academic/personnel documents, departmental reviews, various staff correspondence/documents (1938-1992)

Ua-Rg04-01 Academic Affairs / Office Of The Provost, Archives

Archives Registers

USM self-report to NEASC, policy reports, program curricula, correspondence, fellowship recipients (1965-2008)

Accelerating Transition Of Biotechnology Products For Military Supply Chains, Henry S. Gibbons, Anna M. Crumbley

Joint Force Quarterly

The limited repertoire of the biomanufacturing industry in the 20th century pales in comparison to today’s biotechnology industry, in which advancements in the fields of synthetic biology, artificial intelligence, and robotics have resulted in the rapid expansion of small-scale production capabilities and the development of corresponding high-throughput experimentation platforms that accommodate both generation and downstream processing of biologically derived materials and are poised to revolutionize the way civilian and military sectors produce materials.

Clausewitzian Friction And Twenty-First-Century War—The Paradox Of Technology, Nikolas Gardner

Naval War College Review

New and emerging technologies—especially affecting sensors, networks, autonomy, and computing—are changing Clausewitz’s concept of friction in warfare. While these technologies appear to reduce some aspects of friction, they amplify others and may introduce new ones altogether.

Joint Force Quarterly, Issue 113, 2nd Quarter 2024, National Defense University Press

Joint Force Quarterly

JFQ is certainly the Chairman’s journal, but it exists solely to give voice to you and your ideas on the joint force, jointness in general, and how best to fight and win our Nation’s wars and secure the peace. For over 30 years, the best and brightest among us have sustained the dialogue within these pages, whether physical or virtual. Help us continue this great tradition by sending us your articles and adding to the growing body of knowledge that is Joint Force Quarterly.

Evaluating The Accessibility And Usability Of Electronic Resources In Mizoram University Central Library: A User’S Perspective, Anudha Lepcha, Abhishek Rai, Manendra Kumar Singh

Library Philosophy and Practice (e-journal)

No abstract provided.

"Study, Not Doctrine: Prioritizing History In Jpme, Thomas M. Duffy

Joint Force Quarterly

The article explores the unpredictable and uncertain nature of war, arguing that understanding war requires a descriptive rather than a predictive approach. Strategic forecasting often fails, and the true nature of war is often only clear in hindsight. By examining historical conflicts, we can anticipate challenges in future conflicts. The article seeks to determine the best way to study war to enhance the strategic judgment of future leaders. It emphasizes the importance of a long-term perspective, focusing on the constantly changing character of war rather than the unchanging nature. A history-led approach can create a foundation for future military strategies.

Taking Cues From Complexity: How Complex Adaptive Systems Prepare For All-Domain Operations, Benjamin Selzer

Joint Force Quarterly

How can a complex adaptive systems (CAS) model guide a Service when facing future challenges at the individual and Service/institutional levels? This article provides recommendations on how to address these challenges taken from the study of CAS. These studies can inform efforts to develop doctrine, education, training, planning, and eventual implementation of joint all-domain operations (JADO) doctrine.

2024 June 18 - Medical Student Education Committee Retreat Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Intersection Between Psychopathy And Aggression In Correctional Officers, Lindsay Bergeson

Theses and Graduate Projects

Excessive use of force incidents within the last decade has resulted in high media coverage. One consequence of this high media coverage is the community more frequently questioning the personality characteristics of police and correctional officers. While the literature has begun to dive into the maladaptive traits of police officers and its relationship to excessive use of force, research on this topic in correctional institutions is scarce. The present study examined the relationship between psychopathy, aggression, and use of force in 27 correctional officers (COs) in Minnesota. The study collected self-report data from COs enrolled in Crisis Intervention Training. Using …

Book Review: Age Of Danger: Keeping America Safe In An Era Of New Superpowers, New Weapons, And New Threats, John A. Nagl

Parameters Bookshelf – Online Book Reviews

Authors: Andrew Hoehn and Thom Shanker

Reviewed by Dr. John A. Nagl, professor of warfighting studies, Department of Military Strategy, Planning, and Operations, US Army War College

Dr. John A. Nagl overviews Andrew Hoehn and Thom Shanker’s contributions with their recent book, Age of Danger, which is “well worth readers’ attention.” Nagl describes Hoehn and Shanker’s emphasis on the importance and relationship between the US intelligence community and the US Department of Defense. His review also focuses on the US relationship with China and Russia, the latter of which is featured as “[t]he acute threat” in what Nagl calls …

Daily Eicosapentaenoic Acid Infusion In Iugr Fetal Lambs Reduced Systemic Inflammation, Increased Muscle Adrβ2 Content, And Improved Myoblast Function And Muscle Growth, Haley Beer, Taylor A. Lacey, Rachel L. Gibbs, Micah S. Most, Zena M. Hicks, Pablo C. Grijalva, Eileen S. Marks-Nelson, Ty B. Schmidt, Jessica Lynn Petersen, Dustin T. Yates

Department of Animal Science: Faculty Publications

Intrauterine growth-restricted (IUGR) fetuses exhibit systemic inflammation that contributes to programmed deficits in myoblast function and muscle growth. Thus, we sought to determine if targeting fetal inflammation improves muscle growth outcomes. Heat stress-induced IUGR fetal lambs were infused with eicosapentaenoic acid (IUGR+EPA; n = 9) or saline (IUGR; n = 8) for 5 days during late gestation and compared to saline-infused controls (n = 11). Circulating eicosapentaenoic acid was 42% less (p < 0.05) for IUGR fetuses but was recovered in IUGR+EPA fetuses. The infusion did not improve placental function or fetal O2 but resolved the 67% greater (p < 0.05) circulating TNFα observed in IUGR fetuses. This improved myoblast function and muscle growth, as the 23% reduction (p < 0.05) in the ex vivo differentiation of IUGR myoblasts was resolved in IUGR+EPA myoblasts. Semitendinosus, longissimus dorsi, and flexor digitorum superficialis muscles were 24–39% lighter (p < 0.05) for IUGR but not for IUGR+EPA fetuses. Elevated (p < 0.05) IL6R and reduced (p < 0.05) β2 adrenoceptor content in IUGR muscle indicated enhanced inflammatory sensitivity and diminished β2 adrenergic sensitivity. Although IL6R remained elevated, β2 adrenoceptor deficits were resolved in IUGR+EPA muscle, demonstrating a unique underlying mechanism for muscle dysregulation. These findings show that fetal inflammation contributes to IUGR muscle growth deficits and thus may be an effective target for intervention.

Microglial Piezo1 Mechanosensitive Channel As A Therapeutic Target In Alzheimer's Disease, Erol D Ikiz, Erin R Hascup, Chilman Bae, Kevin N Hascup

Articles

Microglia are the resident macrophages of the central nervous system (CNS) that control brain development, maintain neural environments, respond to injuries, and regulate neuroinflammation. Despite their significant impact on various physiological and pathological processes across mammalian biology, there remains a notable gap in our understanding of how microglia perceive and transmit mechanical signals in both normal and diseased states. Recent studies have revealed that microglia possess the ability to detect changes in the mechanical properties of their environment, such as alterations in stiffness or pressure. These changes may occur during development, aging, or in pathological conditions such as trauma or …

Thz Radar Observations Of Hydrometeors In A Spray Chamber, Zeen Zhu, Fan Yang, Edward Luke, Elise Rosky, Katia Lamer, Pavlos Kollias

Michigan Tech Publications

A THz radar, with its wide bandwidth, is capable of high-resolution imaging down to the centimeter scale. In this study, a THz radar is applied to detect hydrometeors generated in a spray chamber. The observed backscattering signals show fluctuations at centimeter scales, indicating various hydrometeor distribution patterns along the radar beam. A co-located High-Speed Imaging (HSI) sensor is used to measure the Drop Size Distributions (DSD) in the spray chamber. The radar sampling beam is well aligned with the HSI probes, allowing an objective comparison between the remote sensing and in situ observations. In this study, the observed radar power …

Men And Women In Uniform: Insiders’ Perspectives On Women’S Leadership Status In Tanzania People’S Defence Force, Martin Mujuni, Edwin Babeiya,

Journal of Humanities and Social Sciences

This paper examines the leadership status of women in the Tanzania People’s Defence Forces (TPDF). It was guided by three specific objectives: to understand the position of women’s leadership role; identify the challenges constraining women from holding leadership positions; and to examine the measures being taken to enable women hold leadership positions in the TPDF. It collected opinions from the research participants serving—or who served—in the military regarding the position of women as leaders. The study leading to the paper employed a qualitative research approach to collect data from 22 purposively selected respondents. The study found that women hold low …

The Socio-Economic Dynamics Limiting Actions To Combat Child Labour In Tanzania: The Case Of Small-Scale Gold Mining Communities In Tabora Region, Elliott P. Niboye

Journal of Humanities and Social Sciences

This article is based on a study that sought to establish the dynamics that limit actions to combat child labour in small-scale gold mining communities in Tanzania. A qualitative research approach was used to gain a nuanced understanding of the contextual dynamics that limit actions to combat child labour. Other relevant data were sourced from grey literature. Thematic analysis of the collected qualitative data established that the factors limiting actions to combat child labour in small-scale gold mining communities emanate from both household settings and the community at large. The study results revealed several factors that constrain efforts to combat …

Auditory Sensory Gating: Effects Of Noise, Fan-Yin Cheng, Julia Campbell, Chang Liu

Department of Communication Sciences and Disorders Faculty Scholarship and Creative Works

Cortical auditory evoked potentials (CAEPs) indicate that noise degrades auditory neural encoding, causing decreased peak amplitude and increased peak latency. Different types of noise affect CAEP responses, with greater informational masking causing additional degradation. In noisy conditions, attention can improve target signals’ neural encoding, reflected by an increased CAEP amplitude, which may be facilitated through various inhibitory mechanisms at both pre-attentive and attentive levels. While previous research has mainly focused on inhibition effects during attentive auditory processing in noise, the impact of noise on the neural response during the pre-attentive phase remains unclear. Therefore, this preliminary study aimed to assess …

Methods For Detecting And Treating Propranolol Sensitive Tumors, Hana Totary-Jain

USF Patents

The present disclosure relates to methods for detecting and treating propranolol sensitive tumors.

Assessing The Climate Resilience Of Quercus Garryana In The Portland Metro Region, Jess Rose Nettle Shamek

Dissertations and Theses

In the context of rapid global climate change, understanding the resilience of local tree species is essential for fostering effective environmental stewardship and community hopefulness. Oregon white oak (Quercus garryana), an emblematic species in the Pacific Northwest, has faced significant habitat loss and degradation since settler colonization. However, it also exhibits a predicted resilience to climate change, potentially leading to a range shift and expansion. Species resilience refers to the capacity of a species to persist and adapt in the face of rapid global climate change. Beyond vulnerability assessments and niche models, we know little about this species' …

Spatial Transcriptomics Analysis Identifies A Tumor-Promoting Function Of The Meningeal Stroma In Melanoma Leptomeningeal Disease., Hasan Alhaddad, Oscar E. Ospina, Mariam Lotfy Khaled, Yuan Ren, Ethan Vallebuona, Mohammad Baraa Boozo, Peter A. Forsyth, Yolanda Pina, Robert Macaulay, Vincent Law, Kenneth Y. Tsai, W Douglas Cress, Brooke L. Fridley, Inna Smalley

Manuscripts, Articles, Book Chapters and Other Papers

Leptomeningeal disease (LMD) remains a rapidly lethal complication for late-stage melanoma patients. Here, we characterize the tumor microenvironment of LMD and patient-matched extra-cranial metastases using spatial transcriptomics in a small number of clinical specimens (nine tissues from two patients) with extensive in vitro and in vivo validation. The spatial landscape of melanoma LMD is characterized by a lack of immune infiltration and instead exhibits a higher level of stromal involvement. The tumor-stroma interactions at the leptomeninges activate tumor-promoting signaling, mediated through upregulation of SERPINA3. The meningeal stroma is required for melanoma cells to survive in the cerebrospinal fluid (CSF) and …

Tissue‑ And Time‑Dependent Metabolite Profiles During Early Grain Development Under Normal And High Night‑Time Temperature Conditions, Nathan Abshire, Andrew L. Hauck, Harkamal Walia, Toshihiro Obata

Department of Agronomy and Horticulture: Faculty Publications

Background Wheat grain development in the first few days after pollination determines the number of endosperm cells that influence grain yield potential and is susceptible to various environmental conditions, including high night temperatures (HNTs). Flag leaves and seed-associated bracts (glumes, awn, palea, and lemma) provide nutrients to the developing seed. However, the specific metabolic roles of these tissues are uncertain, especially their dynamics at different developmental stages and the time in a day. Tissue- and time-dependent metabolite profiling may hint at the metabolic roles of tissues and the mechanisms of how HNTs affect daytime metabolic status in early grain development. …

Altered Extracellular Matrix Correlates With An Immunosuppressive Tumor Microenvironment And Disease Progression In Younger Adults With Oral Cavity Squamous Cell Carcinoma, Leonard Estephan, Gaurav Kumar, Matthew Stewart, Raphael Banoub, Alban Linnenbach, Larry Harshyne, Ubaldo Martinez-Outshoorn, My Mahoney, Joseph Curry, Jennifer Johnson, Andrew South, Adam Luginbuhl

Kimmel Cancer Center Faculty Papers

INTRODUCTION: Oral cavity squamous cell carcinoma (OSCC) occurs most frequently in patients >60 years old with a history of tobacco and alcohol use. Epidemiological studies describe increased incidence of OSCC in younger adults (years). Despite its poor prognosis, knowledge of OSCC tumor microenvironment (TME) characteristics in younger adults is scarce and could help inform possible resistance to emerging treatment options.

METHODS: Patients with OSCC were evaluated using TCGA-HNSC (n=121) and a stage and subsite-matched institutional cohort (n=8) to identify differential gene expression focusing on the extracellular matrix (ECM) and epithelial-mesenchymal transition (EMT) processes in younger (≤45 years) vs. older adults …

Chromosome-Scale Assemblies And A Pangenome Reveal Ltr Repeat Dynamics As A Major Driver Of Genome Evolution In Chenopodium, Kate E. Jaggi

Theses and Dissertations

The genus Chenopodium, which comprises around 150 species globally, is characterized by its wide geographic distribution and ecological adaptability, particularly in temperate regions. Some species, such as Chenopodium quinoa and Chenopodium pallidicaule, have served as domesticated staple crops in the Andean region of South America for centuries, valued for their robust nutritional profile and adaptability to adverse environmental conditions. In contrast, wild Chenopodium species exhibit broad geographic distributions and diverse niche adaptations, functioning as reservoirs for beneficial traits, including disease resistance and climate hardiness, essential for enhancing domesticated crops through introgression and breeding efforts. However, taxonomic classification within the genus …

Targeting Mcl1-Driven Anti-Apoptotic Pathways Overcomes Blast Progression After Hypomethylating Agent Failure In Chronic Myelomonocytic Leukemia, Guillermo Montalban-Bravo, Natthakan Thongon, Juan Jose Rodriguez-Sevilla, Feiyang Ma, Irene Ganan-Gomez, Hui Yang, Yi June Kim, Vera Adema, Bethany Wildeman, Tomoyuki Tanaka, Faezeh Darbaniyan, Gheath Al-Atrash, Karen Dwyer, Sanam Loghavi, Rashmi Kanagal-Shamanna, Xingzhi Song, Jianhua Zhang, Koichi Takahashi, Hagop Kantarjian, Guillermo Garcia-Manero, Simona Colla

Faculty, Staff and Student Publications

RAS pathway mutations, which are present in 30% of patients with chronic myelomonocytic leukemia (CMML) at diagnosis, confer a high risk of resistance to and progression after hypomethylating agent (HMA) therapy, the current standard of care for the disease. Here, using single-cell, multi-omics technologies, we seek to dissect the biological mechanisms underlying the initiation and progression of RAS pathway-mutated CMML. We identify that RAS pathway mutations induce transcriptional reprogramming of hematopoietic stem and progenitor cells (HSPCs) and downstream monocytic populations in response to cell-intrinsic and -extrinsic inflammatory signaling that also impair the functions of immune cells. HSPCs expand at disease …

A Grounded Theory Analysis Of Honesty And Deception In Intimate Relationships, Lyndsey Kunzler Gerring

Theses and Dissertations

Although honesty is valued in intimate relationships, there has not been significant research on the range and different types of honesty and deception and their impacts on couples. The purpose of this study was to explore and define the role honesty plays in intimate relationships by examining the spectrum of honest and deceptive behaviors as described by participants. The study utilized qualitative methods to examine how romantic partners describe various types of honesty and deception in their relationships and the influence these have. The data was taken from part of a larger project on healthy and unhealthy relationships where semi-structured …

Impacts Of Stream Habitat Restoration On Macroinvertebrate Assemblages: A Systematic Literature Review, Morgan E. Seitzer

University Honors Theses

Globally, river restoration has become a popular tool for improving the health of a watershed and restoring ecosystem services, but still has significant knowledge gaps. In certain areas and scientific communities, special attention has been given to the response of macroinvertebrates as a measure of restoration success. This systematic literature review aims to highlight and discuss the patterns in studies that have comparable before-and-after restoration data on macroinvertebrates after reconnecting stream channels to their floodplains. Macroinvertebrate sampling is a simple if not time-consuming task that can reveal important data about habitat quality. Because they serve as an important food source …

Effects Of Exercise Or Metformin On Myokine Concentrations In Patients With Breast And Colorectal Cancer: A Phase Ii Multi-Centre Factorial Randomized Trial, Justin C. Brown, Guillaume Spielmann, Shengping Yang, Stephanie L.E. Compton, Lee W. Jones, Melinda L. Irwin, Jennifer A. Ligibel, Jeffrey A. Meyerhardt

School of Medicine Faculty Publications

Background: Physical activity and metformin pharmacotherapy are associated with improved clinical outcomes in breast and colorectal cancer survivors. Myokines are cytokines secreted from skeletal muscle that may mediate these associations. Methods: This hypothesis-generating analysis used biospecimens collected from a multi-centre 2 × 2 factorial randomized design of 116 patients with stage I–III breast and colorectal cancer who were randomized to 12 weeks of (1) aerobic exercise (moderate intensity titrated to 220 min/week); (2) metformin (850 mg daily for 2 weeks and then titrated to 850 mg twice per day); (3) aerobic exercise and metformin; or (4) control. Fourteen myokines were …

Mantis Search Algorithm Integrated With Opposition-Based Learning And Simulated Annealing For Feature Selection, Samia Mandour, Abduallah Gamal, Ahmed Sleem

Sustainable Machine Intelligence Journal

Feature selection (FS) plays a vital role in minimizing the high-dimensional data as much as possible to aid in enhancing the classification accuracy and reducing computational costs. The purpose of the FS techniques is to extract the most effective subset features, which might enable the machine learning (ML) algorithms to better grasp the input data’s patterns and improve their classification performance. Although several metaheuristic algorithms have been recently presented to solve this problem, they still suffer from several disadvantages, such as getting stuck in local optima, slow convergence speed, and a lack of population diversity, which prevent them from achieving …