Digital Commons Network^™

Law, Language, And Authority: The Algorithmic Turn, Amanda Turnbull

PhD Dissertations

Law is formed by language and law utilizes language. Law is also like language in that it consists of social rules that aid in the structuring of society. From the time that we first put language into writing, we have been invested in the technologizing of language. There is a clear trajectory of our interest in having machines do things with language that we would otherwise do ourselves. This dissertation investigates how law’s relationship with language changes with the use of algorithmically driven technologies, and correspondingly, the consequences for the changing nature of authority since the use of language in …

Norms And Variance Fail To Predict Butterfly Effects On Social Dynamics By Idiosyncratic Individuals, Stephen F. Stringham, Lynn Rogers, Ann Bryant

Animal Sentience

Adaptations and adjustments to current environmental conditions are manifest in behavioral norms. Knowing norms facilitates population-level prediction, but doesn’t predict individual behavior where idiosyncrasies might trigger “butterfly effects." Knowledge of individual quirks is particularly important for risk assessment and management during close encounters between humans and potentially lethal wildlife, including bears (Ursus spp.). Innovative foraging techniques can alter population vigor and viability. Traits at the tails of a bell curve might hold the greatest potential for adapting to environmental change.

Multimodal Data Integration For Oncology In The Era Of Deep Neural Networks: A Review, Asim Waqas, Aakash Tripathi, Ravi P. Ramachandran, Paul A. Stewart, Ghulam Rasool

Henry M. Rowan College of Engineering Departmental Research

Cancer research encompasses data across various scales, modalities, and resolutions, from screening and diagnostic imaging to digitized histopathology slides to various types of molecular data and clinical records. The integration of these diverse data types for personalized cancer care and predictive modeling holds the promise of enhancing the accuracy and reliability of cancer screening, diagnosis, and treatment. Traditional analytical methods, which often focus on isolated or unimodal information, fall short of capturing the complex and heterogeneous nature of cancer data. The advent of deep neural networks has spurred the development of sophisticated multimodal data fusion techniques capable of extracting and …

Takiri Ake Nga Haeata: Lighting A Path To Increased Indigenous Leadership In Aotearoa, Kaylee Ihimaera

Theses and Dissertations

This thesis addresses the underrepresentation of indigenous Māori people in leadership positions and pursues the need to develop a Māori leadership framework aimed at empowering the next generation of indigenous people. Several frameworks have attempted to exhibit Māori leadership dynamics, each offering unique insights into the cultural and relational aspects of Māori leadership. However, existing frameworks often exhibit limitations in fully encapsulating the breadth of Māori leadership values and practices, necessitating the development of a comprehensive Māori leadership model independent of Western frameworks. Through an extensive review of existing literature and engaging with Māori experts, I synthesized key insights to …

Ultrasonic Cigarettes: Chemicals And Cytotoxicity Are Similar To Heated-Coil Pod-Style Electronic Cigarettes., Esther E. Omaiye, Wentai Luo, Kevin J. Mcwhirter, Prue Talbot

Civil and Environmental Engineering Faculty Publications and Presentations

Our purpose was to test the hypothesis that ultrasonic cigarettes (u-cigarettes), which operate at relatively low temperatures, produce aerosols that are less harmful than heated-coil pod-style electronic cigarettes (e-cigarettes). The major chemicals in SURGE u-cigarette fluids and aerosols were quantified, their cytotoxicity and cellular effects were assessed, and a Margin of Exposure risk assessment was performed on chemicals in SURGE fluids. Four SURGE u-cigarette flavor variants ("Blueberry Ice," "Watermelon Ice," "Green Mint," and "Polar Mint") were evaluated. Flavor chemicals were quantified in fluids and aerosols using gas chromatography/mass spectrometry. Cytotoxicity and cell dynamics were assessed using the MTT assay, live-cell …

In Vivo Evaluation Of Fatty Acid Loaded Chitosan Membranes For Pain Relief And Biofilm Associated Infection Prevention, Yogita Manasa Dintakurthi

Electronic Theses and Dissertations Archive

Infections are the leading cause of burn related deaths worldwide. These infections not only complicate micro-environment of a burn wound, but further obscure the wound due to the formation of biofilms at the wound site. Local drug delivery (LDD) has been a highly researched solution due to its advantages in locally treating and preventing infection while avoiding systemic side effects. LDD systems also have advantages for complex wounds, like burns. Chitosan is a natural polymer that is often used in these systems due to its biodegradability, biocompatibility and versatility. Previous research has suggested that short chain unsaturated fatty acids, for …

10-H2da Coating On Polyvinyl Chloride Catheter Biomaterials For Prevention Of Candida-Associated Urinary Tract Infections, Jermiah Tate

Electronic Theses and Dissertations Archive

Urinary catheters made of polyvinyl chloride (PVC) are susceptible to microbial biofilm formation. 10-hydroxy-2-decenoic acid (10-H2DA) is a dispersal signaling molecule that inhibits biofilm and planktonic growth of microorganisms. This study hypothesized that coating PVC with 10-H2DA would inhibit planktonic and biofilm-associated Candida albicans. Interactions of the PVC and 10-H2DA molecules were analyzed using Video Contact Angle (VCA), Fourier Transform Infrared (FTIR), and High-Performance Liquid Chromatography (HPLC). Successful coating of PVC with 10-H2DA was demonstrated through a significantly lowered contact angle and FTIR peaks in regions indicative of the 10-H2DA on the surface of PVC. Elution data displays a burst …

Long Time Behavior Of Wave And Plate Equations, Madhumita Roy

Electronic Theses and Dissertations Archive

Long time behavior of a class of nonlinear hyperbolic dynamics governed by Partial Differential Equations [PDEs] is considered in this thesis. The objective is to demonstrate that the long-term behavior can be directed towards coherent structures, such as attractors. Attractors are invariant and compact sets in the phase space that attract all trajectories. The key aspects of the dynamics that allow for these descriptions are: (i) a level of dissipation within the system and (ii) the asymptotic smoothness and regularity [compactness] of the trajectories. In this context, hyperbolic dynamics pose a notable challenge as they inherently lack both of these …

A Correctable Immune Niche For Epithelial Stem Cell Reprogramming And Post-Viral Lung Diseases, Kangyun Wu, Yong Zhang, Huiqing Yin-Declue, Kelly Sun, Dailing Mao, Kuangying Yang, Stephen R. Austin, Erika C. Crouch, Steven L. Brody, Derek E. Byers, Christy M. Hoffmann, Michael E. Hughes, Michael J. Holtzman

2020-Current year OA Pubs

Epithelial barriers are programmed for defense and repair but are also the site of long-term structural remodeling and disease. In general, this paradigm features epithelial stem cells (ESCs) that are called on to regenerate damaged tissues but can also be reprogrammed for detrimental remodeling. Here we identified a Wfdc21-dependent monocyte-derived dendritic cell (moDC) population that functioned as an early sentinel niche for basal ESC reprogramming in mouse models of epithelial injury after respiratory viral infection. Niche function depended on moDC delivery of ligand GPNMB to the basal ESC receptor CD44 so that properly timed antibody blockade of ligand or receptor …

Latinos' Intimate Partner Violence, Abuse, And Interventions: Developing A Latcrit Analysis And Critique, Adrian Luis Manriquez, Eric S. Mankowski

Psychology Faculty Publications and Presentations

The paper utilizes LatCrit and critical psychology perspectives in order to review and critique the literature on Latinos' intimate partner violence and abuse and intervention programs. LatCrit theories are described and reviewed, and then applied to the literature on IPV predictors among Latinos. The review demonstrates that the research literature on the predictors, correlates, and antecedents of Latino males' IPV behaviors focuses largely on the individual level of analysis, and consequently suffers from three main limitations: use of deficit models in research; decontextualized assessment and evaluations of IPV; neglect of higher levels of analysis influencing IPV in Latinx communities. Implications …

Rfc-Berkeley Pit Wpp-2024-02, Mark Thompson, Loren Burmeister

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Decoding Anotylus (Thomson 1859) Beetle Diversity: Dna And External Morphology Match In Área De Conservacion Guanacaste, Costa Rica, K. Dante Underwood, Robert Puschendorf, David T. Bilton, Daniel H. Janzen, Winnie Hallwachs, M. Alex Smith

School of Biological and Marine Sciences

Taxonomy underpins biological research because names are needed for comparative analysis, conservation status, and public communication. Despite this, many species remain undescribed and are therefore vulnerable and unprotected, particularly in the tropics. Neotropical Staphylinidae beetles (Coleoptera) are among the insect groups most likely to contain significant unknown and/or cryptic diversity. Here we used an integrative taxonomic framework to conduct a preliminary review of one particularly diverse genus of Staphylinidae (Anotylus) in Área de Conservaciόn Guanacaste, northwestern Costa Rica. We began by DNA barcoding novel collections and using Barcode Index Numbers (BINs) as an estimate of taxonomic diversity; we found 18 …

Csf1r Inhibition Depletes Brain Macrophages And Reduces Brain Virus Burden In Siv-Infected Macaques, Diana G. Bohannon, Laurent D. Zablocki-Thomas, Evan S. Leung, Jinbum K. Dupont, Julian B. Hattler, Jolanta Kowalewska, Miaoyun Zhao, Jiangtao Luo, Marco Salemi, Angela M. Amedee, Qingsheng Li, Marcelo J. Kuroda, Woong-Ki Kim

School of Graduate Studies Faculty Publications

Perivascular macrophages (PVMs) and, to a lesser degree, microglia are targets and reservoirs of HIV and simian immunodeficiency virus (SIV) in the brain. Previously, we demonstrated that colony-stimulating factor 1 receptor (CSF1R) in PVMs was upregulated and activated in chronically SIV-infected rhesus macaques with encephalitis, correlating with SIV infection of PVMs. Herein, we investigated the role of CSF1R in the brain during acute SIV infection using BLZ945, a brain-penetrant CSF1R kinase inhibitor. Apart from three uninfected historic controls, nine Indian rhesus macaques were infected acutely with SIVmac251 and divided into three groups (n = 3 each): an untreated control and …

Blinatumomab For Mrd-Negative Acute Lymphoblastic Leukemia In Adults, Mark R Litzow, Geoffrey L Uy, Et Al.

2020-Current year OA Pubs

BACKGROUND: Many older adults with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) have a relapse despite having a measurable residual disease (MRD)-negative complete remission with combination chemotherapy. The addition of blinatumomab, a bispecific T-cell engager molecule that is approved for the treatment of relapsed, refractory, and MRD-positive BCP-ALL, may have efficacy in patients with MRD-negative remission.

METHODS: In a phase 3 trial, we randomly assigned patients 30 to 70 years of age with

RESULTS: The data and safety monitoring committee reviewed the results from the third efficacy interim analysis and recommended that they be reported. Complete remission with or without full …

A Systematic Study Of The Distribution And Expression Of Aquaporin Water Channels In Normal Adult Human Brain, Oyinkansola Mudasiru, Vivian Etugbo, Reginald Adiele

School of Podiatric Medicine - Student Research

Water regulation in the central nervous system (CNS) is very crucial to maintain normal neurophysiological homeostasis, intracranial pressure and play a role in the pathogenesis of edema and brain disorders. Not only because of the rigidity and limited mobility of the brain encasement that offer little room for fluid expansion, but also the need to maintain an appropriate osmotic balance across the various fluid-filled brain compartments which is necessary for normal neurological functions. Aquaporins (AQPs), a family of non-energy dependent, bidirectional water transport protein channels, play a critical role in maintaining water and electrolyte balance in human brain. The distribution …

Information Geometric Approaches To Optimal Experimental Design And Reduced-Order Modeling In Ocean Acoustics, Jay C. Spendlove

Theses and Dissertations

This thesis demonstrates the application of information geometry to problems in underwater acoustics. Information geometry combines the fields of information theory and differential geometry by interpreting a multiparameter model as a Riemannian manifold in an ambient data space. Information geometry tools are especially powerful in context of problems of experimental design and model selection in ocean acoustics. The application area specifically considered in this research is geoacoustic inversion, where seabed parameter values are inferred from acoustical data. Chapter 2 contains a paper submitted to the Journal of Theoretical and Computational Acoustics, which introduces information geometry tools such as the model …

Sex Influences Of Age Of Onset And Duration Of Illness On Patterns Of Cortical Thickness In Individuals With Schizophrenia, Rachael Olivia Slate

Theses and Dissertations

Given that the manifestation of schizophrenia varies by sex, it is hypothesized that the interaction between diagnosis and sex significantly influences brain structure and is believed to be a crucial factor in understanding the neurobiology of schizophrenia. While much is known about cortical thickness mapping of the condition, there is currently no work that has assessed how changes to the cortical mantle relate to important clinical features of schizophrenia that vary by sex, such as age of illness onset (AOO) or duration of illness (DOI). This study utilized a sex-wise approach to examining cortical thickness alterations in men and women …

Genome-Wide Methylation Patterns In Primary Uveal Melanoma: Development Of Methylsig-Um, An Epigenomic Prognostic Signature To Improve Patient Stratification, Emilie Lalonde, Dong Li, Kathryn Ewens, Carol L. Shields, Arupa Ganguly

Wills Eye Hospital Papers

Despite studies highlighting the prognostic utility of DNA methylation in primary uveal melanoma (pUM), it has not been translated into a clinically useful tool. We sought to define a methylation signature to identify newly diagnosed individuals at high risk for developing metastasis. Methylation profiling was performed on 41 patients with pUM with stage T2-T4 and at least three years of follow-up using the Illumina Infinium HumanMethylation450K BeadChip (N = 24) and the EPIC BeadChip (N = 17). Findings were validated in the TCGA cohort with known metastatic outcome (N = 69). Differentially methylated probes were identified in patients who developed …

Optimizing Lumpfish Rearing, Nicholas Gosling

UNH Today Archive

No abstract provided.

Exploring Students' Perceptions And Experiences Of Faculty Caring In The Undergraduate Classroom In A Traditional Baccalaureate Nursing Program: A Qualitative Descriptive Study, Sheila M. Garilli

Dissertations

Academic nurse educators' use of caring attributes in the classroom could impact students' educational journey. Educators are leaders who should model caring behaviors toward their students. This role modeling will empower students to demonstrate these caring behaviors toward their patients. A literature review discovered a gap surrounding the study of faculty caring in the classroom. This research study explored students' perceptions and experiences of faculty caring in the undergraduate classroom in two traditional baccalaureate nursing programs. This study utilized a qualitative descriptive method with purposeful sampling and in-person recruitment at two universities in a Northeastern state in the United States. …

Workplace Diversity, Equity, And Inclusion In The Retention Of Faculty Women Of Color In Science, Technology, Engineering, And Mathematics, Sherri Reese

Walden Dissertations and Doctoral Studies

Gender discrimination and the underrepresentation of women of color in faculty positions in higher education institutions, especially in the science, technology, engineering, and mathematics (STEM) departments, is a research and policy problem. Despite efforts to improve diversity and inclusion in higher education workplaces, women of color remain largely underrepresented among STEM faculty. Informed by Adams’s equity theory, Tajfel’s social identity theory of organizational commitment, and Bell’s critical race theory, the purpose of this quantitative cross-sectional study was to examine the relationship between diversity and organizational commitment and inclusion and organizational commitment among faculty women of color. Survey data were collected …

Tert Activation Targets Dna Methylation And Multiple Aging Hallmarks, Hong Seok Shim, Jonathan Iaconelli, Xiaoying Shang, Jiexi Li, Zheng D Lan, Shan Jiang, Kayla Nutsch, Brittney A Beyer, Luke L Lairson, Adam T Boutin, Michael J Bollong, Peter G Schultz, Ronald A Depinho

Faculty, Staff and Student Publications

Insufficient telomerase activity, stemming from low telomerase reverse transcriptase (TERT) gene transcription, contributes to telomere dysfunction and aging pathologies. Besides its traditional function in telomere synthesis, TERT acts as a transcriptional co-regulator of genes pivotal in aging and age-associated diseases. Here, we report the identification of a TERT activator compound (TAC) that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. In primary human cells and naturally aged mice, TAC-induced elevation of TERT levels promotes telomere synthesis, blunts tissue aging hallmarks with reduced cellular senescence and inflammatory cytokines, and silences p16INK4a expression via upregulation of DNMT3B-mediated promoter hypermethylation. In the brain, …

Antiformer: Graph Enhanced Large Language Model For Binding Affinity Prediction, Qing Wang, Yuzhou Feng, Yanfei Wang, Bo Li, Jianguo Wen, Xiaobo Zhou, Qianqian Song

Faculty, Staff and Student Publications

Antibodies play a pivotal role in immune defense and serve as key therapeutic agents. The process of affinity maturation, wherein antibodies evolve through somatic mutations to achieve heightened specificity and affinity to target antigens, is crucial for effective immune response. Despite their significance, assessing antibody-antigen binding affinity remains challenging due to limitations in conventional wet lab techniques. To address this, we introduce AntiFormer, a graph-based large language model designed to predict antibody binding affinity. AntiFormer incorporates sequence information into a graph-based framework, allowing for precise prediction of binding affinity. Through extensive evaluations, AntiFormer demonstrates superior performance compared with existing methods, …

Stratasys Printed 3-D Mandibular Molar With Tooth Anatomy And Texture, M. Austin White, Charles E. Taylor, Edwin Kee, Albert F. Mcmullen

School of Dentistry Faculty Publications

Introduction: We used CBCT scans of a human mandibular molar in concert with the Stratasys 3-D printer to fabricate said teeth with similar texture and hardness to enamel, dentin, and cementum. The printed tooth should also have the same crown and root anatomy, as well as root canal anatomy of the scanned tooth. Methods: One mandibular first molar was scanned (Carestream Dental CS 9600 CBCT) and printed (Stratasys 3D multi-material printer). A (Micromet 5104) hardness tester was used to test the hardness of the printed tooth. Nine combinations of two different materials (Stratasys’ Vero Pure White and Agilus 30 Clear …

Randomized, Double-Blind, Placebo-Controlled Study Of Anti-Mycobacterial Therapy (Rhb-104) In Active Crohn's Disease, David Y Graham, Saleh A Naser, Thomas Borody, Zbigniew Hebzda, Harry Sarles, Scott Levenson, Robert Hardi, Tomasz Arłukowicz, Petar Svorcan, Reza Fathi, Aida Bibliowicz, Patricia Anderson, Patrick Mclean, Clara Fehrmann, M Scott Harris, Shuhong Zhao, Ira N Kalfus

Faculty, Staff and Students Publications

This study, conducted between 4 October 2013, and 30 November 2018, tested the hypothesis that triple antimicrobial therapy, targeting Mycobacterium avium subspecies paratuberculosis (MAP), long considered a putative cause, would favorably affect Crohn’s disease. A double-blind multicenter study of adults with active Crohn’s disease, (i.e., Crohn’s Disease Activity Index [CDAI] 220–450 plus C-reactive protein ≥ 1.0 mg/dL, fecal calprotectin (FCP) >162.9 µg/g stool, or recent endoscopic or radiographic confirmation of active disease) receiving concomitant standard-of-care Crohn’s disease treatment (Clinicaltrials.gov: NCT01951326) were stratified by anti-tumor necrosis factor use and randomized (1:1) to anti-MAP RHB-104 (clarithromycin 95 mg, rifabutin 45 mg, …

Vaccine Value Profile For Hookworm, Karl Philipp Puchner, Maria Elena Bottazzi, Victoria Periago, Martin Grobusch, Rick Maizels, James Mccarthy, Bruce Lee, Erika Gaspari, David Diemert, Peter Hotez

Faculty, Staff and Students Publications

Hookworm, a parasitic infection, retains a considerable burden of disease, affecting the most underprivileged segments of the general population in endemic countries and remains one of the leading causes of mild to severe anemia in Low and Middle Income Countries (LMICs), particularly in pregnancy and children under 5. Despite repeated large scale Preventive Chemotherapy (PC) interventions since more than 3 decades, there is broad consensus among scholars that elimination targets set in the newly launched NTD roadmap will require additional tools and interventions. Development of a vaccine could constitute a promising expansion of the existing arsenal against hookworm. Therefore, we …

The Interplay Between Gender And Duration Of Hospitalization Modulates Psychiatric Symptom Severity In Subjects With Long Covid-19, Alessio Simonetti, Antonio Restaino, Claudia Calderoni, Emanuela De Chiara, Antonio Maria D'Onofrio, Salvatore Lioniello, Giovanni Camardese, Delfina Janiri, Matteo Tosato, Francesco Landi, Gabriele Sani

Faculty, Staff and Students Publications

Long COVID-19 is characterized by ongoing symptoms or prolonged or long-term complications of SARS-CoV-2 contraction which persist beyond 4 weeks from the initial onset of symptoms. Gender and duration of hospitalization (DH) are key risk factors for developing long COVID-19 syndrome, but their impact and interplay need further study. This research involved 996 long COVID-19 patients, and we compared the levels of general psychopathology, depression, agitated depression, anxiety, and medication use between hospitalized and non-hospitalized males and females. In the hospitalized patients, multivariate regressions assessed the impact of gender, DH, and the interaction of these variables. The females had higher …

Effects Of Premortem Stress On Protein Expression, Steak Color, Oxidation, And Myofibrillar Fragmentation Index In The Longissimus Lumborum, Reganne K. Briggs, Jerrad F. Legako, Paul R. Broadway, Jeff A. Carroll, Nicole C. Burdick Sanchez, Nikole E. Ineck, Zachary K. Smith, Ranjith Ramanathan, Kara J. Thornton

Animal, Dairy, and Veterinary Science Faculty Publications

No abstract provided.

Comparison Between Ribosomal Assembly And Machine Learning Tools For Microbial Identification Of Organisms With Different Characteristics, Stephanie Chau, Carlos Rojas, Jorjeta G. Jetcheva, Mary Markart, Sudha Vijayakumar, Sophia Yuan, Vincent Stowbunenko, Amanda N. Shelton, William B. Andreopoulos

Faculty Research, Scholarly, and Creative Activity

Background: Genome assembly tools are used to reconstruct genomic sequences from raw sequencing data, which are then used for identifying the organisms present in a metagenomic sample. Methodology: More recently, machine learning approaches have been applied to a variety of bioinformatics problems, and in this paper, we explore their use for organism identification. We start by evaluating several commonly used metagenomic assembly tools, including PhyloFlash, MEGAHIT, MetaSPAdes, Kraken2, Mothur, UniCycler, and PathRacer, and compare them against state-of-the-art deep learning-based machine learning classification approaches represented by DNABERT and DeLUCS, in the context of two synthetic mock community datasets. Results: Our analysis …

Evaluating The Antibacterial Efficacy Of A Silver Nanocomposite Surface Coating Against Nosocomial Pathogens As An Antibiofilm Strategy To Prevent Hospital Infections, James Butler, Sian Morgan, Lewis Jones, Mathew Upton, Alexandros Besinis

School of Engineering, Computing and Mathematics

Antimicrobial nanocoatings may be a means of preventing nosocomial infections, which account for significant morbidity and mortality. The role of hospital sink traps in these infections is also increasingly appreciated. We describe the preparation, material characterization and antibacterial activity of a pipe cement-based silver nanocoating applied to unplasticized polyvinyl chloride, a material widely used in wastewater plumbing. Three-dimensional surface topography imaging and scanning electron microscopy showed increased roughness in all surface finishes versus control, with grinding producing the roughest surfaces. Silver stability within nanocoatings was >99.89% in deionized water and bacteriological media seeded with bacteria. The nanocoating exhibited potent antibiofilm …