Digital Commons Network^™

An Applied Mental Health Course And Student Well-Being, Alison Nicole Anglen

Theses and Dissertations

Addressing mental health concerns and promoting well-being is imperative for university students to function optimally and to succeed academically. The demand for mental health care is exceeding the capacity of traditional counseling center resources at universities, suggesting the need for innovative interventions that can serve a broader scope of students. There is emerging evidence suggesting that mental health can be addressed, and well-being improved through psychoeducation and applied skills taught in classroom settings. Objectives: To examine a Mental Health and Well-Being course at a large, private religious university and its relationship to students’ well-being. This will be measured by assessing …

In Silico Analysis Of The Rop29 Protein As A Vaccine Candidate Against Toxoplasma Gondii, Amir Karimipour-Saryazdi, Fatemeh Ghaffarifar, Abdolhossein Dalimi, Masoud Foroutan, John Horton, Javid Sadraei

Faculty, Staff and Student Publications

The progression of Toxoplasma gondii (T. gondii) invasion is aided by rhoptry proteins (ROPs), which are also crucial for the parasite's survival in host cells. In this study, in silico analysis was performed to examine the various aspects of the ROP29 protein, such as physicochemical properties, potential T- and B-cell epitopes, and other significant features. The research revealed that there were 55 possible sites for posttranslational modification in the ROP29 protein. The secondary structure of the ROP29 protein consists of a random coil, an alpha-helix, and an extended strand, which account for 49.69%, 36.81%, and 13.50%, respectively. Moreover, …

Detection Of Diffusely Abnormal White Matter In Multiple Sclerosis On Multiparametric Brain Mri Using Semi-Supervised Deep Learning, Benjamin C Musall, Refaat E Gabr, Yanyu Yang, Arash Kamali, John A Lincoln, Michael A Jacobs, Vi Ly, Xi Luo, Jerry S Wolinsky, Ponnada A Narayana, Khader M Hasan

Faculty, Staff and Student Publications

In addition to focal lesions, diffusely abnormal white matter (DAWM) is seen on brain MRI of multiple sclerosis (MS) patients and may represent early or distinct disease processes. The role of MRI-observed DAWM is understudied due to a lack of automated assessment methods. Supervised deep learning (DL) methods are highly capable in this domain, but require large sets of labeled data. To overcome this challenge, a DL-based network (DAWM-Net) was trained using semi-supervised learning on a limited set of labeled data for segmentation of DAWM, focal lesions, and normal-appearing brain tissues on multiparametric MRI. DAWM-Net segmentation performance was compared to …

The Impact Of The Covid-19 Pandemic On The Incidence Of Sexual Assaults And Victim Services, Jessica Hunter

Student Works

The Impact of the Covid-19 Pandemic on the Incidence of Sexual Assaults and Victim Services

Purpose: The purpose of this literature review is to discuss incidents/rates of sexual assaults (SA), access to or accessibility of SA victim services, and the utilization of SA services during the COVID-19 pandemic.

Background: In the U.S., 1 in 5 women experience rape or attempted rape, while 1 in 4 men experience some form of sexual violence in their lifetime. Additionally, SAs affect roughly one-third of the world's population, making SA a prominent problem worldwide.

Methods: Electronic searches in CINHAL and MEDLINE were performed using …

Impact Of Covid-19 On Dental Students’ Mental Health Status And Perception Of Sars-Cov-2 Vaccine, Man Hung, Nicole Hablitzel, Sharon Su, Samantha Melnitsky, Amir Mohajeri

Pacific Faculty Work

The COVID-19 pandemic disrupted dental education significantly, forcing adaptations in both didactic and clinical curricula. This study evaluates the impact of COVID-19 on dental students’ mental health and perceptions of the SARS-CoV-2 vaccine. An anonymous online survey was administered to dental students at Roseman University of Health Sciences, focusing on health experiences and vaccination perceptions. Results showed 56.8% of students were concerned about their emotional health, 82.1% felt stressed, and 60.6% felt depressed. About 81.9% received the vaccine, with 75.5% believing it effective, though only 55.3% supported mandatory vaccination. The pandemic negatively impacted students’ emotional health, indicating a need for …

Salivary Proteins In Human Acquired Enamel Pellicle (Aep) On Eroded And Uneroded Teeth In Patients With Gastro-Oesophageal Reflux Disease (Gord), Rasha Alharthi, Mahdi Mutahar, David Bartlett, Jafar Jafari, Rebecca Moazzez

Pacific Faculty Work

The aim of this in vivo study was to compare total protein present in the salivary films (F) and acquired enamel pellicle (AEP) on eroded and non-eroded surfaces in patients suffering from GORD symptoms with and without GORD diagnosis (GORD, No-GORD). Thirty-nine patients suffering from GORD symptoms and erosive tooth wear on lower first molars and an unaffected posterior occlusal surface in the same quadrant were recruited from Guy’s hospital, London. Salivary film and AEP were collected from the eroded and uneroded occlusal surfaces, using 0.5% sodium dodecyl sulphate (SDS)-soaked filter papers. Total protein concentration was analysed using bicinchoninic acid …

Msw Portfolio: Falling Into Place, Rebecca P. Whitesell

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

2024 Summer Undergraduate Research Program, University Of Northern Iowa. Summer Undergraduate Research Program.

Summer Undergraduate Research Program (SURP) Symposium Programs

The program for the Summer Undergraduate Research Symposium of the College of Humanities, Arts and Sciences.

From Steps To Strides: My Evolving Journey Into Social Work, Lacresha N. Ffrench

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This paper reflects on my journey, shaped by my heritage as a first-generation Jamaican-American and my experiences in education. The narrative begins with the story of my parents, Desmond and Pauline Ffrench, who immigrated from Jamaica with the hope of providing me with greater opportunities. Their sacrifices and unwavering support have been instrumental in my success. My career in education began in 2019, where I transitioned through various roles, from an educational assistant to the restorative practices coordinator. These experiences, coupled with my deepening commitment to advocating for students, led me to pursue a master's in social work. Encouraged by …

Risk Factors Associated With Pyogenic Spinal Infections Among Intravenous Drug Users And Nonusers, Vivek Biololikar, Brendan Gleason, Lee Kripke, Robert Merrill, Colin Whitaker, Jon Handal

Einstein Health Papers

PURPOSE: To identify the differences in patient factors, presentation, treatment course, and outcomes of intravenous drug users (IVDA) vs. nonusers (non-IVDA) presenting with pyogenic spinal infections.

METHODS: We identified all cases involving spinal infections at our institution between May 2017 and January 2023. Postsurgical infections were excluded, and patients were separated into IVDA and non-IVDA groups. The patient charts were reviewed and analyzed for statistical or clinically significant differences using RStudio (2019 version 3.6.2). Our institutional review board approved this study, IRB# 2020-277, iRISID-2023-1384.

RESULTS: Fifty patients (29 males and 21 females) with primary pyogenic spinal infections were included in …

Gaze Preferences To Male Contrapposto And Non-Contrapposto Postures, Farid Pazhoohi, Oliver Lee Jacobs, Alan Kingstone

School of Psychology

Contrapposto, an asymmetrical twisting of the hips and shoulders, has historically been associated with beauty and aesthetics in art. While the impact of a female contrapposto posture on perception of attractiveness and visual attention has been studied, its effects on males remain understudied. The current research aims to explore whether contrapposto postures in men influence perceptions of attractiveness, dominance, masculinity, dynamism, and naturalness, as well as visual attention. Two eye-tracking studies were conducted, utilizing images of male models in contrapposto and upright poses. Despite differences in attributions, no significant differences were found in visual attention between the two poses in …

Detection And Mitigation Of Misleading Pheromone Trails In Foraging Robot Swarms, Ryan Luna, Qi Lu

Computer Science Faculty Publications

This study addresses the overlooked aspect of security in swarm robotics by exploring the vulnerabilities of stigmergic communication in foraging robot swarms. More specifically, we study the swarm's susceptibility to attacks that introduce misleading pheromone trails. Simulated scenarios in which detractor robots lay misleading trails to deceive benign foraging robots effectively reduce the foraging performance of the swarm. We analyze the impact of the attack on the swarm and evaluate the reduction of foraging efficiency. We introduce a defense mechanism using distance-based clustering (DBSCAN) along with a cluster grouping method to isolate large batches of detractors early in the simulation. …

Selection For Robust Metabolism In Domesticated Yeasts Is Driven By Adaptation To Hsp90 Stress, Natalia Condic, Hatim Amiji, Dipak Patel, William Charles Shropshire, Nejla Ozirmak Lermi, Youssef Sabha, Beryl John, Blake Hanson, Georgios Ioannis Karras

Faculty, Staff and Student Publications

Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors within industrial domestication niches. Ethanol disrupts critical Hsp90-dependent metabolic pathways and exerts strong selective pressure for redundant duplications of key genes within these pathways, yielding the classical genomic signatures of beer and bread domestication. This work demonstrates a mechanism of adaptive canalization in an ecology of major economic importance and highlights Hsp90-dependent variation as an important source of phantom heritability in complex traits.

Enhancement Of Mechanical Properties Of Pcl/Pla/Dmso2 Composites For Bone Tissue Engineering, Kyung-Eun Min, Jae-Won Jang, Cheolhee Kim, Sung Yi

Mechanical and Materials Engineering Faculty Publications and Presentations

Bone tissue engineering shows potential for regenerating or replacing damaged bone tissues by utilizing biomaterials renowned for their biocompatibility and structural support capabilities. Among these biomaterials, polycaprolactone (PCL) and polylactic acid (PLA) have gained attention due to their biodegradability and versatile applications. However, challenges such as low degradation rates and poor mechanical properties limit their effectiveness. Dimethyl sulfone (DMSO₂) has emerged as a potential additive to address these limitations, offering benefits such as reduced viscosity, increased degradation time, and enhanced surface tension. In this study, we investigate tailored composites comprising PLA, PCL, and DMSO₂ to enhance mechanical …

Computational Modelling And Design Of Antibodies: Benefits From Analysis Of Their Unique Structural Motifs, Katherine M. Mccoy

Dartmouth College Ph.D Dissertations

The complexes that antibodies make with their binding partners, or antigens, are especially valuable to be able to predict and modify due to their unique role in the immune system. Yet, they present significant challenges to computational methods of both modelling and design. Antibodies are unlike most other proteins in that they are composed of a scaffold region, which is a highly conserved structure that is largely the same between antibodies of the same class, and Complementary Determining Regions (CDRs), which are comprised of hypervariable loops that largely determine their binding motifs. Additionally, antibodies and their antigens do not co-evolve …

Antimicrobials Produced By Ants: Chemical Properties And Microbe Specificity, Katy Chon

Master's Theses

Antibiotic resistance is a growing public health concern worldwide, and for over a decade, we have been witnessing the growth of difficult to treat infectious diseases caused by bacteria that are becoming resistant to antibiotics. This resistance can be mostly related to the misusing and improper use of antibiotics in both humans and animals. To restore this problem, humans have turned to new sources for the production of antibiotics. In this study, we focused on using ants. Social insects, including ants and bees, have faced strong disease pressures during their evolution and have developed a range of methods to fight …

Influence Of Adiposity And Sex On Sars-Cov-2 Antibody Response In Vaccinated University Students: A Cross-Sectional Esfuerso Study, Adriana L. Perales-Torres, Lucia M. Perez-Navarro, Esperanza M. Garcia-Oropeza, Alvaro Diaz-Badillo, Yoscelina Estrella Martinez-Lopez, Marisol Rosas-Diaz, Octelina Castillo-Ruiz, Laura Yanneth Ramirez-Quintanilla, Leonel Vela, Beatriz Tapia, Juan C. Lopez-Alvarenga

School of Medicine Publications

Prior studies have identified various determinants of differential immune responses to COVID-19. This study focused on the Ig-G anti-RBD marker, analyzing its potential correlations with sex, vaccine type, body fat percentage, metabolic risk, perceived stress, and previous COVID-19 exposure. In this study, data (available in S1 Data) were obtained from 108 participants from the ESFUERSO cohort, who completed questionnaires detailing their COVID-19 experiences and stress levels assessed through the SISCO scale. IgG anti-RBD concentrations were quantified using an ELISA assay developed by UNAM. Multiple regression analysis was employed to control for covariates, including sex, age, body fat percentage, body …

High School Sport Participation: Effects On Students' Grit And Resilience, Rory Kekoa-Israel Waldman

Theses and Dissertations

Adolescence is a time of transition, growth, and identity exploration. Often this great time for growth is accompanied with an increase in stressors that can be detrimental to success and health, without the necessary coping mechanisms. It is a period of life where resilience and grit are extremely important. A post-traumatic growth definition for resilience allows for the possibility of a steeling effect, in which the resilience of an adolescent can grow and develop. Sport provides an ideal environment for the development of both grit and resilience by providing a safe environment for adversity to occur without detrimental consequences. In …

Rational Design Of Lignin-First Biorefineries Through Lignin Analysis And Deconstruction Modeling Tools, Aditya Ponukumati

McKelvey School of Engineering Graduate Student Theses & Dissertations

Lignocellulosic biomass is produced photosynthetically from atmospheric CO2 and is one of the few sources of renewable, reduced carbon that is generated on a scale comparable to demand for chemical commodities. For a sense of scale, the U.S. Energy Security and Independence Act targets the production of approximately 16 billion gallons per year of second-generation lignocellulosic biofuels by 2025. That production would generate approximately 62 million tons per year of dry lignin byproducts. The focus of this dissertation is on the valorization of these lignin components of biomass. Currently, lignin is either discarded or burned for local heat or electricity …

Diapause Specific Proteins Of A Brine Shrimp Form Liquid Droplets Dependent On Salt And Ph Levels, Kolby Sanders, Alex Haydon, Charles Elder, David Grimm, Michael Menze

Undergraduate Research Events

Liquid-Liquid Phase Separation (LLPS) is a process when a polypeptide condenses into a dense and dilute phase in aqueous solutions. Within cells, this process is believed to relate to stress regulation and various cellular processes. Several stress-related proteins found only during the embryonic developmental stage of diapause in the brine shrimp, A. franciscana, have been observed to undergo LLPS in vitro. Our results show that the small heat shock protein (sHSP) p26 has a greater propensity to LLPS under varying salt concentrations compared to LEA6, a late embryogenesis abundant protein (LEA). At a protein concentration of 1.31 mg/ml in …

Characterizing A Complex Ct-Rich Haplotype In Intron 4 Of Snca Using Large-Scale Targeted Amplicon Long-Read Sequencing, Pilar Alvarez Jerez, Kensuke Daida, Francis P Grenn, Laksh Malik, Abigail Miano-Burkhardt, Mary B Makarious, Jinhui Ding, J Raphael Gibbs, Anni Moore, Xylena Reed, Mike A Nalls, Syed Shah, Medhat Mahmoud, Fritz J Sedlazeck, Egor Dolzhenko, Morgan Park, Hirotaka Iwaki, Bradford Casey, Mina Ryten, Cornelis Blauwendraat, Andrew B Singleton, Kimberley J Billingsley

Faculty, Staff and Students Publications

Parkinson's disease (PD) is a common neurodegenerative disorder with a significant risk proportion driven by genetics. While much progress has been made, most of the heritability remains unknown. This is in-part because previous genetic studies have focused on the contribution of single nucleotide variants. More complex forms of variation, such as structural variants and tandem repeats, are already associated with several synucleinopathies. However, because more sophisticated sequencing methods are usually required to detect these regions, little is understood regarding their contribution to PD. One example is a polymorphic CT-rich region in intron 4 of the SNCA gene. This haplotype has …

Exposure To Light At Night And Risk Of Cancer: A Systematic Review, Meta-Analysis, And Data Synthesis, Samuel Ma, Yossef Alsabawi, Hashem B El-Serag, Aaron P Thrift

Faculty, Staff and Students Publications

BACKGROUND: Emerging interest surrounds the role of environmental factors, notably exposure to light at night (LAN), as a potential cause of cancer. The aim of this study was to conduct a systematic review and, if possible, meta-analysis of observational studies on LAN and cancer risk of multiple types.

METHODS: A systematic literature search in PubMed, Web of Science, and Embase, spanning from inception to May 2023, was conducted. Studies focusing on the association between LAN exposure and cancer risk in adult populations were included. We used random effects models to calculate pooled risk estimates (RR) and 95% confidence intervals (CI). …

N-Myc And Stat Interactor Is An Endometriosis Suppressor, Yuri Park, Xiaoming Guan, Sang Jun Han

Faculty, Staff and Students Publications

In patients with endometriosis, refluxed endometrial fragments evade host immunosurveillance, developing into endometriotic lesions. However, the mechanisms underlying this evasion have not been fully elucidated. N-Myc and STAT Interactor (NMI) have been identified as key players in host immunosurveillance, including interferon (IFN)-induced cell death signaling pathways. NMI levels are markedly reduced in the stromal cells of human endometriotic lesions due to modulation by the Estrogen Receptor beta/Histone Deacetylase 8 axis. Knocking down NMI in immortalized human endometrial stromal cells (IHESCs) led to elevated RNA levels of genes involved in cell-to-cell adhesion and extracellular matrix signaling following IFNA treatment. Furthermore, NMI …

Exposure To Light At Night And Risk Of Cancer: A Systematic Review, Meta-Analysis, And Data Synthesis, Samuel Ma, Yossef Alsabawi, Hashem B. El-Serag, Aaron P. Thrift

School of Medicine Publications

Simple Summary

Cancer is the second leading cause of death globally, and the causes of cancer are numerous and multifactorial, including genetic and environmental factors. There is a developing interest in the role of sleep and light at night (LAN) exposure in cancer development. The aim of our study is to further understand the relationship between LAN exposure and the risk of cancer by systematically reviewing existing literature assessing LAN exposure and the risk of various cancer types. We found a positive association between LAN exposure and breast cancer risk, but there was insufficient data to convincingly draw a conclusion …

Global Burden Of Five Major Types Of Gastrointestinal Cancer, Arjun Singh

Division of Gastroenterology and Hepatology Faculty Papers

Gastrointestinal (GI) cancers cause major global morbidity and mortality, with over 5 million new cases and 3.5 million deaths in 2020. The most prevalent GI malignancies are colorectal, gastric, liver, oesophageal, and pancreatic cancers. Marked geographic variations exist, with high incidence in developed regions contrasting with high mortality in developing areas. These patterns reflect disparities in risk factors and cancer control capacities. However, GI cancer incidence is rising with economic growth and lifestyle changes. Poor prognosis and increasing burden underscore the critical need for expanded prevention and research. This review examines global epidemiology, risks, prevention, detection, treatment, and priorities for …

Cognitive Warfare: The Fight For Gray Matter In The Digital Gray Zone, Michael J. Cheatham, Angelique M. Geyer, Priscella A. Nohle, Jonathan E. Vazquez

Joint Force Quarterly

Τhe United States is facing unprecedented challenges in the cognitive domain. While democracies struggle to develop frameworks that promote collective understanding, adversaries are employing gray zone tactics—those that never rise to the level of war—as a form of cognitive warfare against the United States and other democratic societies. François du Cluzel, head of innovative projects at the North Atlantic Treaty Organization (NATO)’s Allied Command Transformation Innovation Hub, describes the key distinctions of the emerging cognitive domain:

Cognitive warfare degrades the capacity to know, produce, or thwart knowledge. Cognitive sciences cover all the sciences that concern knowledge and its processes (psychology, …

Modeling The Effect Of Human Behavior On Disease Transmission, Katie Yan

Rose-Hulman Undergraduate Mathematics Journal

Many infectious disease models build upon the classic Susceptible-Infected-Recovered (SIR) model, a compartmental system that is used to simulate disease transmission in a population. The SIR model focuses on the transmission of disease but rarely includes behavioral or informational components that explore how disease perception influences transmission. In this paper, we propose a six-compartment behavioral SIR model that further segments the classic SIR system based on knowledge of information about the disease, and we explore how sharing information affects disease transmission. We designate two states as aware and unaware based on whether the relevant information is known by the population. …

It’S Getting Hot In Here: Maine’S Right To Food As A Mechanism To Address The Impact Of The Warming Of The Gulf Of Maine On Lobster, Rachel Fischer

Maine Law Review

In United States v. Washington, the Ninth Circuit considered a series of treaties called the Stevens Treaties between the Washington state government and a group of twenty-one Native American nations in the pacific northwest. The court held that embedded in a treaty right to take fish was a promise by the Washington state government that fish would still exist in that region. This case ultimately required the state government to protect the region’s fish against environmental degradation. In the age of climate change, this case provides a model for states like Maine to impose a duty on the state government …

Medical School Watercooler Newsletter - July 25, 2024, Lindsay Hughes

Watercooler Newsletter

This is the July 25, 2024 edition of the Frederick P. Whiddon College of Medicine’s newsletter - Watercooler.

Contents Include

• Mark your calendar for upcoming Watermark Faculty Success workshops
• MCI researchers receive gift from Norma Livingston Foundation to study ovarian cancer
• New chief of adolescent medicine joins pediatrics faculty
• Ramani visits Guatemala as part of international clinical trial
• Finding career paths — and love — in graduate program

Law, Language, And Authority: The Algorithmic Turn, Amanda Turnbull

PhD Dissertations

Law is formed by language and law utilizes language. Law is also like language in that it consists of social rules that aid in the structuring of society. From the time that we first put language into writing, we have been invested in the technologizing of language. There is a clear trajectory of our interest in having machines do things with language that we would otherwise do ourselves. This dissertation investigates how law’s relationship with language changes with the use of algorithmically driven technologies, and correspondingly, the consequences for the changing nature of authority since the use of language in …