Digital Commons Network^™

The Potential Influence Of Immune Modulatory Molecules (Tgf-Βiii And Ctla-4) In Pathogenicity Of Pcos, Mustafa Riyadh Abdullah, Hazima Mossa Alabassi

Karbala International Journal of Modern Science

Polycystic ovary syndrome (PCOS) is characterised by chronic anovulation, hyperandrogenism, polycystic ovaries, and immunological dysregulation. Immune homeostasis and inflammation management require immune functions. T-regulatory cells (Tregs) regulate PCOS's immune system, inflammation, insulin resistance, ovarian function, and homeostasis. Transforming growth factor βIII (TGF-βIII) and Cytotoxic-T-lymphocyte-associated-protein-4 (CTLA-4) receptors on the surfaces of Treg cells are important for controlling the immune system. The study included 68 PCOS patients and 22 non-PCOS women controls aged 20–45. The waist-hip ratio (WHR) determines obesity. We evaluated serum levels and gene expression of TGF-βIII and CTLA-4 via ELISA and real-time PCR. Women with PCOS had significantly higher …

Enhanced Optoelectronics Performance Of Hybrid Self Power Photodetectors Go: Tio2- Ad / N-Si Heterojunctions, Mohammed J. Alsultani, Maysoon F. Alias

Karbala International Journal of Modern Science

A GO:TiO₂/n-Si heterostructure has been submerged in an anthocyanin dye solution that extracted from the red cabbage plant creates a high responsivity, self-powered UV, and visible photodetectors fabricated by the spray pyrolysis technique. The GO concentrations are varied, whereas TiO₂ is fixed. Thin films' structure, shape, and optical characteristics were examined using X-ray diffraction, field emission scanning electron microscopy, and UV-Vis spectrophotometers respectively. Island-like polycrystalline film powders with grain boundaries and granular shapes are created. Two direct energy gaps between 3.33-3.02 and 2.39-2.04 eV exist in all films. J-V characteristics were examined. The saturation current density (J …

Study Impact Smoking On Sperm Morphology And Dna Fragmentation In Iraqi Male Fertility, Talal Z. Al-Darawsha, Mohammed H. Shaban, Ali H. Jawad

Al-Ameed Journal for Medical Research and Health Sciences

Background: Male infertility is issue a prevalent, involves various factors. Sperm quality, particularly influenced by smoking, is crucial for fertility. DNA fragmentation, indicating damage to DNA strands in sperm cells, is gaining importance in male infertility research, especially concerning abnormal sperm morphology.

Aim: To investigate the potential influence of smoking on both sperm morphology and DNA fragmentation in male fertility.

Materials and Methods: In this cross-sectional observational study, 83 participants (38 nonsmokers and 45 smokers) with Normozoospermia provided informed consent. Semen samples were collected following at WHO 2021 guidelines. Sperm morphology was evaluated using Kruger Strict Criteria with Hematoxylin stain, …

Modeling Virus Diffusion On Social Media Networks With The Smirq Model, Justin Browning, Arnav Mazumder, Gowri Nanda

Rose-Hulman Undergraduate Mathematics Journal

As social networking services become more complex and widespread, users become increasingly susceptible to becoming infected with malware and risk their data being compromised. In the United States, it costs the government billions of dollars annually to handle malware attacks. Additionally, computer viruses can be spread through schools, businesses, and individuals’ personal devices and accounts. Malware affecting larger groups of people causes problems with privacy, personal files, and financial security. Thus, we developed the probabilistic SMIRQ (pSMIRQ) model that shows how a virus spreads through a generated network as a way to track and prevent future viruses. Our model is …

The Effect Of Moon Phase On Predator And Prey Activity Levels On Turnbull National Wildlife Refuge, Jeff Schell, Charlotte Milling

2024 Symposium

Variation in nighttime illumination linked to moon phase has been demonstrated to affect the activity patterns of both prey and predator species. However, evidence of lunarphobia in ungulates is mixed. Turnbull National Wildlife Refuge (TNWR) in Spokane County spans 23,000 acres; features a diverse landscape of channeled scablands, wetlands, and Ponderosa pine (Pinus ponderosa); and is situated within 20 km of the second largest city in Washington. Our objective was to assess the influence of nighttime illumination on activity levels of common mammals on TNWR by quantifying the relationship between moon phase and visitation rate at trail cameras …

Constraining The Evolutionary Stages Of A Hypogene Karst System By Combining Morphological, Geochemical And Geochronological Data - The Example Of Carbonate Breccia-Hosted Melnička Peštera, Marjan Temovski, Zsófia Ruszkiczay-Rüdiger, Kata Molnár, László Rinyu, Alexander Wieser, Oscar Marchhart, László Palcsu

International Journal of Speleology

A combination of morphological observations, geochemical data from calcite minerals and geochronology by burial age dating and U-series is used to constrain the geological and geomorphological setting and the evolutionary stages of a hypogene karst system. This methodological suit is applied to Melnička Peštera, a horizontal cave developed in carbonate breccia overlying dolomite marble in Melnica locality (N. Macedonia), where hydrothermal karst development occurred in both dolomite and calcite marble. The passage morphology of the cave, having a reverse triangle, Laughöhle cross-sections, suggests development near the water table by slowly moving waters. Calcite crusts are found throughout the cave, and …

Co2 Hypogene Speleogenesis In An Endogenic Travertine System, Mesa Del Oro, New Mexico, Usa, Victor J. Polyak, Jeffrey R. Forbes, Michael N. Spilde, Paula P. Provencio, John R. Cochran, Yemane Asmerom

International Journal of Speleology

The Mesa del Oro travertine, deposited by upwelling CO₂-rich spring waters, is a large and thick mantle of calcite overlying soft Triassic Chinle Formation mudstones in western central New Mexico, USA. The travertine contains a system of small caves known as the Pronoun Cave Complex. Whut Cave is the largest known cave in the complex. While the travertine hydrologic system is no longer active, there is ample evidence that Whut Cave was formed by hypogene speleogenesis. The Whut Cave entrance is a small roughly circular shaft that descends ~four meters and intersects a linear fissure-controlled passage. Mn-oxide was …

Home Birth Vs Hospital Birth In Low-Risk Pregnancies In The United States - What Is Safest?, Emily Borsellino

Summer Interdisciplinary Research Symposium

Objective: Determine a difference in a home versus hospital birth on neonatal and maternal mortality, intrapartum intervention rates, postpartum care, and overall cost in the United States.

Methods: Multiple online databases were used to find research articles that focused on home and hospital births. Studies with a publication date from 2018 to present were used to determine an up to date and accurate review of this topic.

Results: Neonatal adverse outcomes are less likely in-home births, and the lowest neonatal mortality rate is seen in midwife-assisted hospital birth in the United States. The maternal mortality rate is …

Adult Zymosan Re-Exposure Exacerbates The Molecular Alterations In The Brainstem Rostral Ventromedial Medulla Of Rats With Early Life Zymosan-Induced Cystitis, Bhavana Talluri, Sankar Addya, Maia Terashvili, Bidyut K. Medda, Anjishnu Banerjee, Reza Shaker, Jyoti N. Sengupta, Banani Banerjee

Kimmel Cancer Center Papers, Presentations, and Grand Rounds

Recent evidence suggests that the descending modulatory pathways from the brainstem rostral ventromedial medulla (RVM) are important for bladder inflammatory pain. This study aimed to identify the long-term molecular changes in RVM neurons due to early life cystitis during neuronal development and the effect of reexposure later in adulthood. RVM tissues from two treatment protocols were used: (1) neonatal zymosan exposures with acute adult rechallenge (RC) and (2) only neonatal zymosan exposures (NRC). RNAseq analysis showed upregulation of several genes associated with synaptic plasticity (Grin1, Grip2, Notch1, Arc, and Scn2b) in the cystitis groups compared to controls in both protocols. …

Understanding Environmental Impacts On N. Crassa, Siobhan Cleveland, James Livengood, Michael Watters

Summer Interdisciplinary Research Symposium

This experiment aimed to test the limits of environmental extremes that Neurospora crass could withstand. Due to our limited ability to manipulate all conditions simultaneously, these conditions were studied independently. To study low-pressure effects on N. crassa, inoculated plates were placed in a vacuum chamber at varying pressures to see what growth effects would transpire, including the search for the threshold for development. High gravity experiments were conducted by inoculating nutrient media tubes, running them in a centrifuge at increasing speeds, measuring in revolutions per minute, and finally evaluating growth length up the sides of the tube. This procedure …

The Impact Of Early Lifer Adversity On Mental And Physical Health: The Role Of Spirituality And Forgiveness, Julia Luisa Goldmark

ETD Collection

ABSTRACT The current study aimed to examine the effect of adverse childhood experiences on mental and physical health, forgiveness and spirituality. A total of 579 adults between the ages of 18 and 32 years completed an online survey. Participants were asked to report demographics and completed various measures. A total of 579 adults between the ages of 18 and 32 years were recruited through a university in New York and completed an online survey. Results from this study found that adverse childhood experiences predicted poor self-reported health, a greater number of somatic symptoms, and a greater number of symptoms of …

"When Animals Dream - Exploring Consciousness And Ethics In David M. Pena Guzman's New Book, Andrew Rowan

Tales of WellBeing

David M. Peña-Guzmán’s latest book explores the fascinating question of whether animals dream, delving into the scientific, philosophical, and ethical implications of animal consciousness.

Do Paternal Factors Have An Impact On Preeclampsia?, Brianna Latisnere-Blosser

Summer Interdisciplinary Research Symposium

Objective: To find how the father plays a role in maternal outcomes, particularly preeclampsia.

Methods: Using online databases and the search terms maternal outcomes, paternal genome, preeclampsia, and paternal health, 5 studies were identified for this paper. They include prospective cohort studies, retrospective cohort studies, meta-analysis, and systematic reviews.

Results: The father does play a role in preeclampsia, but not in terms of genetics. His health and the time over which the woman is exposed to his sperm have been found to be related to risk of preeclampsia.

Conclusion: Paternal variables such as preconception health and sperm exposure timeline have …

Examining Long-Term Outcomes Of Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement: A Review, Alec Vanderzee

Summer Interdisciplinary Research Symposium

Objective: Aortic valve stenosis is the most common valvular disease in developed countries, with notable patient morbidity and mortality. Historically, it has been treated with surgical aortic valve replacement (SAVR). In the last 25 years, the development of transcatheter aortic valve replacement (TAVR) has revolutionized this treatment, offering a much less invasive procedure. Current literature supports equivalent mortality after 1 year for both procedures, but long-term evaluation has not been well studied. The objective of this paper is to evaluate the efficacy of SAVR vs TAVR at 5 years.

Methods: A literature search was conducted utilizing PubMed, Google Scholar, and …

From Deleuze And Guattari’S Interregnum To Our Own, Or How To Navigate The Coming Post-Neoliberal Age, Samuel Weeks, Evan Lyons

College of Humanities and Sciences Faculty Papers

No abstract provided.

Diesel Exhaust Particles Alter Mitochondrial Bioenergetics And Camp Producing Capacity In Human Bronchial Epithelial Cells, Isabella Cattani-Cavalieri, Marina Trombetta-Lima, Hong Yan, Ana L. Manzano-Covarrubias, Hoeke A. Baarsma, Asmaa Oun, Melissa Mol Van Der Veen, Emily Oosterhout, Amalia M. Dolga, Rennolds S. Ostrom, Samuel Santos Valenca, Martina Schmidt

Pharmacy Faculty Articles and Research

Introduction: Air pollution from diesel combustion is linked in part to the generation of diesel exhaust particles (DEP). DEP exposure induces various processes, including inflammation and oxidative stress, which ultimately contribute to a decline in lung function. Cyclic AMP (cAMP) signaling is critical for lung homeostasis. The impact of DEP on cAMP signaling is largely unknown.

Methods: We exposed human bronchial epithelial (BEAS-2B) cells to DEP for 24–72 h and evaluated mitochondrial bioenergetics, markers of oxidative stress and inflammation and the components of cAMP signaling. Mitochondrial bioenergetics was measured at 72 h to capture the potential and accumulative effects of …

Lure Specificity, Phenology, And Damage Caused By Epiphyas Moths (Lepidoptera: Tortricidae) In Western Australian Apple Orchards, Maryam Yazdani, Elliot T. Howse, Wee Tek Tay, Helen Spafford, Rieks Van Klinken

Horticulture Research Articles

Multiple Epiphyas species inhabit southwestern Western Australia, including Light Brown Apple Moth (LBAM) Epiphyas postvittana (Walker) (Lepidoptera: Tortricidae), a globally significant, polyphagous pest. This study evaluated the efficacy and specificity of lures designed for 3 Epiphyas species: E. postvittana, Epiphyas pulla (Turner), and the undescribed Epiphyas sp. (1) (Common). Additionally, the study sought to determine the presence and distribution of Epiphyas species in 3 significant apple-growing localities. Trapping, together with partial sequencing of the mitochondrial COI gene, found LBAM to be restricted to the Perth Hills and E. pulla, to apple orchards near Manjimup and Pemberton. This geographic …

Samantha Langley-Turnbaugh Named Inaugural Vice President For Academic Research, University Of Dayton

News Releases

Samantha Langley-Turnbaugh, vice provost for graduate education, research and outreach, and director of online education at Northern Kentucky University, will become vice president for academic research at the University of Dayton Sept. 1.

Central Lean Mass Distribution And The Risks Of All-Cause And Cause-Specific Mortality In 40,283 Uk Biobank Participants, Li Ding, Yuxin Fan, Jiaxing Wang, Xiaohui Ma, Lina Chang, Qing He, Gang Hu, Ming Liu

Population and Public Health Science Faculty Publications

Introduction: The purpose of this study was to investigate the association of central lean mass distribution with the risk of mortality. Methods: This cohort study included 40,283 UK Biobank participants. Cox proportional hazards regression models were used to estimate the association of central lean mass distribution, i.e., trunk-to-leg lean mass ratio, assessed by dual-energy X-ray absorptiometry, with the risk of mortality. Results: The median age of the participants was 65 years, and 52% were women. During a median follow-up of 4.18 years, 674 participants died, of whom 366 were due to cancer and 126 were due to cardiovascular causes. Compared …

Three Essays In Food Security And The U.S. Sugar Program, Jacob Michels

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Chapter one devises an approach to adjust estimates of the number of food insecure for changes in sedentarism over time. Existing methodologies are biased upwards and date back several decades. We build a household model utilizing a Stone-Geary utility function, which rationalizes households shifting their labor decisions towards sedentary activities. Our comparative statics examine the impacts of changes in the productivities of sedentary types, as opposed to my physically demanding types, of activities and also their returns. Our empirical approach is informed by our theoretical model and comparative statics, in which we construct a unique pseudo-panel dataset. Sitting time serves …

Instrumentation Failure In Adult Spinal Deformity Patients, David P Falk, Ravi Agrawal, Bijan Dehghani, Rohit Bhan, Sachin Gupta, Munish C Gupta

2020-Current year OA Pubs

In recent years, advances in the surgical treatment of adult spinal deformity (ASD) have led to improved outcomes. Although these advances have helped drive the development of deformity surgery to meet the rising volume of patients seeking surgical treatment, many challenges have yet to be solved. Instrumentation failure remains one of the most common major complications following deformity surgery, associated with significant morbidity due to elevated re-operation rates among those experiencing mechanical complications. The two most frequently encountered subtypes of instrumentation failure are rod fracture (RF) and proximal junctional kyphosis/proximal junctional failure (PJK/PJF). While RF and PJK/PJF are both modes …

Beta-Blockers As An Immunologic And Autonomic Manipulator In Critically Ill Patients: A Review Of The Recent Literature, Akram M. Eraky, Yashwanth Yerramalla, Adnan Khan, Yasser Mokhtar, Mostafa Alamrosy, Amr Farag, Alisha Wright, Matthew Grounds, Nicole M. Gregorich

GME Publications

The autonomic nervous system plays a key role in maintaining body hemostasis through both the sympathetic and parasympathetic nervous systems. Sympathetic overstimulation as a reflex to multiple pathologies, such as septic shock, brain injury, cardiogenic shock, and cardiac arrest, could be harmful and lead to autonomic and immunologic dysfunction. The continuous stimulation of the beta receptors on immune cells has an inhibitory effect on these cells and may lead to immunologic dysfunction through enhancing the production of anti-inflammatory cytokines, such as interleukin-10 (IL-10), and inhibiting the production of pro-inflammatory factors, such as interleukin-1B IL-1B and tissue necrotizing factor-alpha (TNF-alpha). Sympathetic …

Social Media Addiction And Psychological Well-Being Among Adolescents In Malaysia: A Preliminary Study In Testing Mediating Effect Of Social Support, Ling Chong Shue, Xin Tiong Sheena Yin

Research Publications (2021 to 2025)

Malaysia is experiencing exponential increase of social media users and adolescents contribute substantially to this phenomenon. As adolescents are considered to be the most vulnerable age group in relation with psychosocial issues, we seek to determine if problematic use of social media affects psychological health and sleep of adolescents. We also seek to examine if social support mediate the said relationships.

Understanding The Structure Of Digital Health And The Epic System In Healthcare, Blaise B. Nieve

General Submissions: Presentations (Oral and Poster)

Digital health represents the convergence of digital technologies with healthcare to enhance the efficiency, effectiveness, and personalization of medical services. This lecture delves into the expansive domain of digital health, exploring its components, significance, and transformative potential.

The Experiences Of Jamaican Secondary School Counselors Who Provide Psychological Support To Adolescents, Onnica Morris

Walden Dissertations and Doctoral Studies

School counselors play an integral role in helping adolescents navigate and overcome the psychological distress that they experience. This study aimed to better understand the experiences of Jamaican school counselors who provide psychological support to adolescents in high school. Urie Bronfenbrenner’s (2006) bioecological model of human development and Hans-Georg Gadamer's (1981) hermeneutic theory formed the conceptual framework for this study. Seven Jamaican secondary school counselors who provide psychological support to adolescents in high school participated in semistructured interviews via the Zoom online platform. Narrative analysis was used to code and analyze the data from the interviews. Seven themes emerged from …

Sublime And Extended Reality Experiences To Enhance Emotional Wellbeing For Autistic People: A State Of The Art Review And Narrative Synthesis, Chris Bennewith, Johara Bellali, Lance Watkins, Samuel Tromans, Kamaldeep Bhui, Rohit Shankar

More Faculty of Arts, Humanities and Business Research

Background: Sublime is a centuries old concept of emergent experience arising from immense and threatening awareness provoked by overwhelming fear and dread when faced with an incomprehensible situation as is common to autistic people. Extended Reality (XR) technologies have been used since the mid-1990s, in regulating emotions, behaviour and supporting social skill development for autistic people. Aims: To understand utility of XR technologies in creating immersive experiences for autistic people to alleviate anxiety and the relationship to the sublime. Method: A State of the Art literature review and narrative synthesis was conducted. PubMed, CINAHL, EMBASE, Cochrane Library, Scopus, Web of …

Selvaduray, Guna S., San Jose State University

Emeritus and Retired Faculty Biographies

Stanford University, 1978 Ph.D.

Stanford University, 1976 M.S.

Tokyo Institute of Technology, 1969 B.S.

Differential Lipid Binding Specificities Of Rap1a And Rap1b Are Encoded By The Amino Acid Sequence Of The Membrane Anchors, Mussie K Araya, Wei Chen, Yuepeng Ke, Yubin Zhou, Alemayehu A Gorfe, John F Hancock, Junchen Liu

Faculty, Staff and Student Publications

RAP1 proteins belong to the RAS family of small GTPases that operate as molecular switches by cycling between GDP-bound inactive and GTP-bound active states. The C-terminal anchors of RAP1 proteins are known to direct membrane localization, but how these anchors organize RAP1 on the plasma membrane (PM) has not been investigated. Using high-resolution imaging, we show that RAP1A and RAP1B form spatially segregated nanoclusters on the inner leaflet of the PM, with further lateral segregation between GDP-bound and GTP-bound proteins. The C-terminal polybasic anchors of RAP1A and RAP1B differ in their amino acid sequences and exhibit different lipid binding specificities, …

The Advent Of Quantum Computer Music: Mapping The Field, Eduardo Miranda

School of Art, Design and Architecture

Quantum computing technology is developing at a fast pace. The impact of quantum computing on the music industry is inevitable. This paper maps the emerging field of quantum computer music. Quantum computer music investigates, and develops applications and methods to process music using quantum computing technology. The paper begins by contextualising the field. Then, it discusses significant examples of various approaches developed to date to leverage quantum computing to learn, process and generate music. The methods discussed range from rendering music using data from physical quantum mechanical systems and quantum mechanical simulations to computational quantum algorithms to generate music, including …

Evaluating Mountain Lion Diet Before And After A Removal Of Feral Horses In A Semiarid Environment, Peter C. Iacono, Kathryn A. Schoenecker, Kezia R. Manlove, Pat J. Jackson, David C. Stoner

Wildland Resources Faculty Publications

Non-native species can affect ecosystems by influencing native predator-prey dynamics. Therefore, management interventions designed to remove non-natives may inadvertently lead to increased predation on native species. Feral horses are widely distributed throughout the arid parts of western North America. A growing body of research indicates that horses can be an important prey species to mountain lions in ecosystems where they overlap. In December 2020, the Bureau of Land Management removed 455 horses from the Delamar Mountains, Nevada, USA. We leveraged this management intervention to implement a before–after–control–impact study to test hypotheses about predation on horses and native ungulates. We predicted …