Digital Commons Network^™

Activation Of A Gpcr, Orl1 Receptor: A Novel Therapy To Prevent Heart Failure Progression, Saliha S Pathan, Aarthi Pugazenthi, Beverly R E A Dixon, Theodore G Wensel, Todd K Rosengart, Megumi Mathison

Faculty, Staff and Students Publications

The number of ischemic heart failure (HF) patients is growing dramatically worldwide. However, there are at present no preventive treatments for HF. Our previous study showed that Gata4 overexpression improved cardiac function after myocardial infarction in rat hearts. We also found that Gata4 overexpression significantly increased the expression of a Pnoc gene, an endogenous ligand for the cell membrane receptor ORL1. We hypothesized that the activation of the ORL1 receptor would suppress HF in a rat ischemic heart model. Adult Sprague Dawley rats (8 weeks old, six males and six females) underwent left anterior descending coronary artery ligation. Three weeks …

Extending The Translational Science Benefits Model To Implementation Science For Cancer Prevention And Control, Karen M Emmons, Ross C Brownson, Douglas A Luke

2020-Current year OA Pubs

INTRODUCTION: There is increasing pressure on the federal research budget and shifting public opinions about the value of the academic enterprise. We must develop and apply metrics that demonstrate the broad benefits of research for health and society. The Translational Science Benefits Model (TSBM) measures the impact of large-scale translational science initiatives, such as the National Cancer Institute's Cancer Moonshot. TSBM provides the scaffolding to illustrate how science has real-world health impacts. We propose an expansion of the TSBM to explicitly include implementation-focused outcomes.

METHODS: TSBM includes four categories of benefits, including (1) clinical and medical, (2) community and public …

Clock Hijackers: How Integration Of Glioblastoma Into Circadian Circuits Regulates Tumor Progression And Sensitivity To Current Therapies, Maria Felicita Gonzalez

Arts & Sciences Graduate Student Theses and Dissertations

Glioblastoma (GBM) is the most common primary brain tumor in adults with a poor prognosis despite aggressive therapy. A recent, retrospective clinical study found that administering chemotherapy with Temozolomide (TMZ) in the morning increased patient overall survival by 6 months compared to evening. Previous work has shown that murine and human models of GBM have cell-intrinsic circadian rhythms in expression of the core clock genes Bmal1 and Per2 in vitro. This suggests that GBM has circadian rhythms that entrain to the hosts’ central clock. Understanding the mechanisms underlying circadian entrainment and tumor growth in GBM is essential to determine whether …

Examining Wildfire Dynamics Using Ecostress Data With Machine Learning Approaches: The Case Of South-Eastern Australia's Black Summer, Yuanhui Zhu, Shakthi B. Murugesan, Ivone K. Masara, Soe W. Myint, Joshua B. Fisher

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Wildfires are increasing in risk and prevalence. The most destructive wildfires in decades in Australia occurred in 2019–2020. However, there is still a challenge in developing effective models to understand the likelihood of wildfire spread (susceptibility) and pre-fire vegetation conditions. The recent launch of NASA's ECOSTRESS presents an opportunity to monitor fire dynamics with a high resolution of 70 m by measuring ecosystem stress and drought conditions preceding wildfires. We incorporated ECOSTRESS data, vegetation indices, rainfall, and topographic data as independent variables and fire events as dependent variables into machine learning algorithms applied to the historic Australian wildfires of 2019–2020. …

Classification Manner Utilizing Electroencephalography Signals To Investigate Waveforms, Wessam Al-Salman, Ali Basim Al-Khafaji, Mishall Al-Zubaidie

Karbala International Journal of Modern Science

Waveform detection has been an area of continuous investigation for many years. One important waveform in sleep stage 2 is the k-complex. Numerous researchers have created various strategies for auto-k-complex detection; some of these strategies state that the automated detection techniques are adequate. Because of its analytically relevant resolution, the Electroencephalogram (EEG) is a commonly utilized technique to analyze the k-complexes in order to understand the nervous system activity of the brain. Several researchers have classified waveforms using EEGs in a variety of ways. It appears that the majority of the waveform detection had limitations. The …

Bacterial Cellulose Production From Fermented Fruits And Vegetables Byproducts: A Comprehensive Study On Chemical And Morphological Properties, Yati Maryati, Hakiki Melanie, Windri Handayani, Yasman Yasman

Karbala International Journal of Modern Science

This study aimed to produce α-cellulose from Bacterial Cellulose SCOBY (BCS) using alternative substrates from fermented fruit and vegetable byproducts: katuk leaves (KT), kale leaves (KL), guava (JB), dragon fruit (NG), and banana (PS). BCS production involved juice extraction, SCOBY inoculation, and sucrose addition, followed by 21 days of fermentation. Initially, the NG medium had the highest concentration of Total Reducing Sugars (TRS), but all media showed a decline as sugars were consumed. Fermentation reduced pH and increased total polyphenols, with KL and JB showing the highest rise (0.13-0.15 mg GAE/mL). Flavonoid levels varied, decreasing in KL and PS but …

Metabolite Profiling Of Potential Fraction From Ethyl Acetate Extract Of Ziziphus Mauritiana Leaves By Lc-Ms/Ms Analysis, Nurhayati Bialangi, Weny Ja Musa, Boima Situmeang

Karbala International Journal of Modern Science

In Indonesia, the treatment with leaves as a traditional medicine is still firmly integrated into the community to overcome various health problems experienced, one of which is the treatment with Bidara leaves (Ziziphus mauritiana). Ziziphus mauritiana belongs to family of Rhamnaceae, and it is generally considered a potential source of antioxidant and cholesterol lowering. This study aimed to examine phytochemical characterization, antioxidant potential, and cholesterol-lowering effects of ethyl acetate fraction derived from Ziziphus mauritiana. Extraction was accomplished using ethyl acetate, and the resultant extract was fractionated through chromatography with a blend of n-hexane and ethyl acetate as …

Revitalizing The Curriculum Collection: A Collaborative Partnership Approach, Kimberly T. Foster, Eric Resnis

South Carolina Libraries

As K-12 education has increasingly focused on standardized testing, university curriculum centers have had to adjust their holding to offer more curricula-focused material. These collections can be vital for the development of pre-service teachers, who often need access to the learning materials that they will later use. This article explores the steps taken by a university library to revitalize a curriculum collection in order to offer more curriculum-based holdings for pre-service teachers to use.

Girls, Guns, And Zombies: Five Dimensions Of Teaching And Learning In The Walking Dead, Anthony Neely

Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy

Rooted in sociocultural theory, this article utilizes a conceptual framework derived from Alexander, Schallert, and Reynolds’ four topographical dimensions of learning: who of learning, what of learning, where of learning, and when of learning. Situated learning (Lave and Wenger) is presented as a fifth dimension to address how learning occurs in communities of practice absent of formal schooling. Content analysis (Elo and Kyngass) is used to analyze a teaching and learning event from an episode of The Walking Dead based on the five topographical dimensions of learning listed above. Findings provide insights for pedagogical application for …

Tuméfaction Palatine Révélatrice D’Une Tumeur Odontogène Adénomatoide, Mehri Turki

International Arab Journal of Dentistry

Adenomatoid odontogenic tumor is a benign epithelial tumor diagnosed more often in young women and more dominant in the anterior region of the maxilla. The discovery of the tumor is generally seen during a radiological examination. The histological examination is essential to confirm the diagnosis. In the present clinical
case, we review the epidemiological, diagnostic, therapeutic and prognostic characteristics of this type of tumor.

Implant Macro-Design And Primary Stability, An Ex Vivo Study, Emile Chrabieh

International Arab Journal of Dentistry

The aim of the study was to compare the impact of three different implant macro-designs on the primary stability. 25 cylindrical non self-tapping implants (Straumann® SP/TL), 30 hybrid self- tapping implants (Straumann® BL) and 30 tapered selftapping implants (Straumann® BLT) with the same diameter and length (4.1/10mm) were inserted randomly in 30 different bone bloc types on beef ribs. The assessment of the primary stability was carried out by recording the maximum insertion torque IT (DTA device) and the implant stability quotient ISQ using the resonance frequency analysis RFA (with the Osstell device) for each implant design in a same …

Belonging And Heroic Non-Conformity In Marie-Célie Agnant's Femmes Aux Temps Des Carnassiers, Danica L E Guerrero

Tête à Tête: Journal of Francophone Studies

In an effort to maintain power in an authoritarian state, dictators target, silence, and eliminate those unwilling to conform. In Marie-Célie Agnant's 2015 novel Femmes aux temps des carnassiers, Mika Pelrin and her daughter Soledad are kidnapped, raped, and tortured by the Tonton Macoutes because of Mika's refusal to be silenced by the Duvalier regime in 1958. Through this fictional account based on appalling historical events and the tragic fate of journalist Yvonne Hakim Rimpel, Agnant insists on the vital societal role played by courageous women like her defiant character Mika who, through nonconformity and at the risk of their …

The Significance Of Tillage Systems In Kentucky And Illinois On Soil Properties, Madison Westerfield, Ethan White

Scholars Week

Tillage practices have various effects on soil health and soil properties. For example, no-till practices disturb the soil less, preserving soil health. Conventional tillage practices disturb the soil and various properties depending on depth and equipment used. The objective of this research was to compare conventional tillage systems in Illinois against the no-till practices in Kentucky on soil properties changes. The study was conducted in three no-till fields in Ohio County, KY and three conventional tillage fields in Williamson County, IL. Twenty-four samples were pulled, twelve samples from three fields under conventional tillage and twelve samples from three fields under …

Ada News - 11/04/2024, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Ud Students Explore Appalachian Trail Through New Environmental Biology Lab, Elisabeth Watson

College of Arts and Sciences Newsroom

In summer 2024, UD biologist Chelse Prather took a group of students on a backpacking trip through the Blue Ridge Mountains.

The Utah Statesman, November 4, 2024, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

The Plasma Proteome Reveals Markers Of Recent And Repeated Stress In Free-Ranging Seals, Jessica G. Avalos, Cory D. Champagne, Dan E. Crocker, Jane I. Khudyakov

Pacific Faculty Work

Animals in nature potentially experience multiple stressors, and those of anthropogenic origin are likely to be repeated or chronic. However, stress hormone levels are highly context-dependent and are not consistent predictors of chronic stress in wildlife. Profiling the downstream consequences of repeated stress responses, such as changes in metabolism or gene expression, may be more informative for predicting their individual-level health consequences and population-level impacts, which are key objectives for wildlife conservation. We previously found that in free-ranging juvenile elephant seals, the blubber transcriptome and proteome, but not cortisol levels, could distinguish between responses to single versus repeated stress axis …

New Taxa Of Butterflies Supported By Genomic Analysis, Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

Continuing with the genomic analysis of butterflies, we present a taxonomic update. As a result of this work, 3 genera, 6 subgenera, 16 species, and 2 subspecies are described as new. New genera and subgenera are (type species in parenthesis): Systasia Grishin, gen. n. (Hesperia zampa W. H. Edwards, 1876) and Asysta Grishin, gen. n. (Systasea microsticta Dyar, 1923) in Pyrgini Burmeister, 1878 and Alyco Grishin, gen. n. (Styriodes quota Evans, 1955) in Moncina A. Warren, 2008; Ocynthus Grishin, subgen. n. (Ocybadistes hypomeloma Lower, 1911) of Potanthus Scudder, 1872, Arrhona Grishin, subgen. n. (Padraona tranquilla …

Formulating Public Pharma, Shweta Kumar

IPIPC Papers & Reports

In 2022, prices for both brand-name and generic drugs in the U.S. were nearly three times as high as prices in comparably industrialized nations, with the cost of insulin products in particular being nearly ten times as high. As a result, 3 out of 10 American adults cannot afford to take their medication as prescribed. Furthermore, in 2024 the U.S. experienced its worst drug shortage in over a decade, with more than 300 drugs in short supply. Generic drugs are particularly vulnerable to shortage, as manufacturers have poor economic incentives to produce drugs with slim profit margins. While the Biden …

Butterfly Peacock Bass (Cichla Ocellaris) Neurocranium, Jasmyn Todaro, Emma Horton, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

No abstract provided.

Genome-Guided Isolation Of The Hyperthermophilic Aerobe Fervidibacter Sacchari Reveals Conserved Polysaccharide Metabolism In The Armatimonadota, Nancy O. Nou, Jonathan K. Covington, Dengxun Lai, Xavier Mayali, Cale O. Seymour, Juliet Johnston, Jian-Yu Jiao, Steffen Buessecker, Damon Mosier, Alise R. Muok, Nicole Torosian, Allison M. Cook, Ariane Briegel, Tanja Woyke, Emiley Eloe-Fadrosh, Nicole Shapiro, Scott G. Bryan, Savannah Sleezer, Joshua Dimapilis, Cristina Gonzalez, Lizett Gonzalez, Marlene Noriega, Matthias Hess, Ross P. Carlson, Lan Liu, Meng-Meng Li, Zheng-Han Lian, Siqii Zhu, Fan Liu, Xian Sun, Beile Gao, Ritesh Mewalal, Miranda Harmon-Smith, Ian K. Blaby, Jan-Fang Cheng, Peter K. Weber, Gabriela Grigorean, Wen-Jun Li, Anne E. Dekas, Jennifer E. Pett-Ridge, Jeremy A. Dodsworth, Marike Palmer, Brian P. Hedlund

Life Sciences Faculty Research

Few aerobic hyperthermophilic microorganisms degrade polysaccharides. Here, we describe the genome-enabled enrichment and optical tweezer-based isolation of an aerobic polysaccharide-degrading hyperthermophile, Fervidibacter sacchari, previously ascribed to candidate phylum Fervidibacteria. F. sacchari uses polysaccharides and monosaccharides for growth at 65–87.5 °C and expresses 191 carbohydrate-active enzymes (CAZymes) according to RNA-Seq and proteomics, including 31 with unusual glycoside hydrolase domains (GH109, GH177, GH179). Fluorescence in-situ hybridization and nanoscale secondary ion mass spectrometry confirmed rapid assimilation of 13C-starch in spring sediments. Purified GHs were optimally active at 80–100 °C on ten different polysaccharides. Finally, we propose reassigning Fervidibacteria as a class …

Contrasting Responses Of Commercially Important Northwest Atlantic Bivalve Species To Ocean Acidification And Temperature Conditions, Teagan Mcmahon, Diana Thatcher, Branwen Williams, Alan Wanamaker, Brittany Jellison, Heidi Franklin, Katherine Guay, Nina M. Whitney, Joseph A. Stewart, Michèle Lavigne

Faculty Publications

Modern calcifying marine organisms face numerous environmental stressors, including overfishing, deoxygenation, increasing ocean temperatures, and ocean acidification (OA). Coastal marine settings are predicted to become warmer and more acidic in coming decades, heightening the risks of extreme events such as marine heat waves. Given these threats, it is important to understand the vulnerabilities of marine organisms that construct their shells from calcium carbonate, which are particularly susceptible to warming and decreasing pH levels. To investigate the response of four commercially relevant bivalve species to OA and differing temperatures, juvenile Mercenaria mercenaria (hard shell clams), juvenile Mya arenaria (soft shell clams), …

‘Foundations Of The Mind, Brain, And Behavioral Relationships’: A Combined Faculty And Student’S Perspective Of A New Textbook On Clinical Neuroscience, Richard J. Addante, Jahdiel Perez Caban, Sarah E. Smith

Psychology Faculty Publications

The textbook, ‘Foundations of the Mind, Brain, and Behavioral Relationships’ (Moini et al., Citation2023), is one of the newest textbooks in neuroscience to arrive. The market for textbooks in the field of neuroscience is competitive among several excellent comparators, but critical market gaps still remain to be filled, notably the area of clinical neuroscience that is both advanced in content but accessible to students. One of the reasons that this gap has existed in the field is precisely because it can be a very difficult a mark to hit: how does one present neurobiological content that is …

Nepali Oral Microbiomes Reflect A Gradient Of Lifestyles From Traditional To Industrialized, Erica Ryu, Yoshina Gautam, Diana Proctor, Dinesh Bhandari, Sarmila Tandukar, Meera Gupta, Guru Prasad Gautam, David Relman, Ahmed Shibl, Jeevan Bahadur Sherchand, Aashish Jha, Emily Davenport

SKMC Student Presentations and Publications

BACKGROUND: Lifestyle plays an important role in shaping the gut microbiome. However, its contributions to the oral microbiome remain less clear, due to the confounding effects of geography and methodology in investigations of populations studied to date. Furthermore, while the oral microbiome seems to differ between foraging and industrialized populations, we lack insight into whether transitions to and away from agrarian lifestyles shape the oral microbiota. Given the growing interest in so-called "vanishing microbiomes" potentially being a risk factor for increased disease prevalence in industrialized populations, it is important that we distinguish lifestyle from geography in the study of microbiomes …

Guidelines For The Prevention, Diagnosis, And Management Of Urinary Tract Infections In Pediatrics And Adults: A Wikiguidelines Group Consensus Statement, Zachary Nelson, Abdullah Tarik Aslan, Nathan P. Beahm, Michelle Blyth, Matthew Cappiello, Danielle Casaus, Fernando Dominguez, Susan Egbert, Alexandra Hanretty, Tina Khadem, Katie Olney, Ahmed Abdul-Azim, Gloria Aggrey, Daniel T. Anderson, Mariana Barosa, Michael Bosco, Elias B. Chahine, Souradeep Chowdhury, Alyssa Christensen, Daniela De Lima Corvino, Margaret Fitzpatrick, Molly Fleece, Brent Footer, Emily Fox, Bassam Ghanem, Fergus Hamilton, Justin Hayes, Boris Jegorovic, Philipp Jent, Et Al

School of Medicine Faculty Publications

IMPORTANCE: Traditional approaches to practice guidelines frequently result in dissociation between strength of recommendation and quality of evidence. OBJECTIVE: To create a clinical guideline for the diagnosis and management of urinary tract infections that addresses the gap between the evidence and recommendation strength. EVIDENCE REVIEW: This consensus statement and systematic review applied an approach previously established by the WikiGuidelines Group to construct collaborative clinical guidelines. In May 2023, new and existing members were solicited for questions on urinary tract infection prevention, diagnosis, and management. For each topic, literature searches were conducted up until early 2024 in any language. Evidence was …

Nepali Oral Microbiomes Reflect A Gradient Of Lifestyles From Traditional To Industrialized, Erica P Ryu, Yoshina Gautam, Diana M Proctor, Dinesh Bhandari, Sarmila Tandukar, Meera Gupta, Guru Prasad Gautam, David A Relman, Ahmed A Shibl, Jeevan Bahadur Sherchand, Aashish R Jha, Emily R Davenport

Faculty, Staff and Student Publications

Background: Lifestyle plays an important role in shaping the gut microbiome. However, its contributions to the oral microbiome remain less clear, due to the confounding effects of geography and methodology in investigations of populations studied to date. Furthermore, while the oral microbiome seems to differ between foraging and industrialized populations, we lack insight into whether transitions to and away from agrarian lifestyles shape the oral microbiota. Given the growing interest in so-called "vanishing microbiomes" potentially being a risk factor for increased disease prevalence in industrialized populations, it is important that we distinguish lifestyle from geography in the study of microbiomes …

Genetic Risk Factors Underlying White Matter Hyperintensities And Cortical Atrophy, Yash Patel, Jean Shin, Eeva Sliz, Ariana Tang, Aniket Mishra, Rui Xia, Edith Hofer, Hema Sekhar Reddy Rajula, Ruiqi Wang, Frauke Beyer, Katrin Horn, Max Riedl, Jing Yu, Henry Völzke, Robin Bülow, Uwe Völker, Stefan Frenzel, Katharina Wittfeld, Sandra Van Der Auwera, Thomas H Mosley, Vincent Bouteloup, Jean-Charles Lambert, Geneviève Chêne, Carole Dufouil, Christophe Tzourio, Jean-François Mangin, Rebecca F Gottesman, Myriam Fornage, Reinhold Schmidt, Qiong Yang, Veronica Witte, Markus Scholz, Markus Loeffler, Gennady V Roshchupkin, M Arfan Ikram, Hans J Grabe, Sudha Seshadri, Stephanie Debette, Tomas Paus, Zdenka Pausova

Faculty, Staff and Student Publications

White matter hyperintensities index structural abnormalities in the cerebral white matter, including axonal damage. The latter may promote atrophy of the cerebral cortex, a key feature of dementia. Here, we report a study of 51,065 individuals from 10 cohorts demonstrating that higher white matter hyperintensity volume associates with lower cortical thickness. The meta-GWAS of white matter hyperintensities-associated cortical 'atrophy' identifies 20 genome-wide significant loci, and enrichment in genes specific to vascular cell types, astrocytes, and oligodendrocytes. White matter hyperintensities-associated cortical 'atrophy' showed positive genetic correlations with vascular-risk traits and plasma biomarkers of neurodegeneration, and negative genetic correlations with cognitive functioning. …

Understanding The Demographic And Health Factors Associated With The Incidence Of Stroke In Jamaica, Zandy Elliott

Walden Dissertations and Doctoral Studies

Stroke, the leading cause of death and disability worldwide, is a significant public health issue in Jamaica, affecting individuals, families, and the healthcare system. This study identified demographic and health factors associated with stroke, enabling medical professionals to better understand high-risk factors and implement preventative care strategies in Jamaica—filling a significant gap in public health knowledge. The quantitative cross-sectional study examined Jamaican demographics, health, and stroke rates. Secondary data from the Office of the Consultant Neurologist (OCN) from 2000-2023 was integrated into the Social Ecological Model (SEM). The study included 291 stroke patients aged 18 and older, excluding those under …

The Rider (2024-11-04), Natalie Lapsley

The Rider Archives

Vol.10 No.11

Dosimetric Comparison Of 3d Conformal And Vmat With Dibh For Right Breast Cancer, Lundie Cervantes

Masters Projects

This study explores the use of the Deep Inspiration Breath Hold (DIBH) technique in radiotherapy for right-sided breast cancer, comparing the dosimetric outcomes of 3D conformal radiation therapy (3DCRT) and volumetric modulated arc therapy (VMAT). Using a retrospective design, ten patients with prior left breast DIBH scans were analyzed to assess right breast radiation dose distributions to critical organs at risk (OARs), including the heart, lungs, liver, and contralateral breast. Each patient’s treatment plan was developed for both VMAT and 3DCRT using Varian Eclipse software.

The results show that 3DCRT significantly lowered mean heart dose (0.56 Gy vs. 1.26 Gy, …