Digital Commons Network^™

Design And Synthesis Of Therapeutic Molecules Targeted At Metabolic Pathways Of Cancer And Lipid Signaling In Fungal Diseases, Jennifer Uzoamaka Nnaemeka

All Theses

Cancer remains a leading cause of global mortality, with 20 million new cases and 9.7 million deaths recorded in 2022 (WHO, 2024). While advancements like nanoparticles and monoclonal antibodies offer new treatments, they often cause severe toxicity to normal cells. This study introduced novel thiamin-based compounds targeting enzymes critical for cancer cell proliferation. These compounds were synthesized via a three-step process involving tosylation, SN2 coupling with phenolic compounds, and subsequent reactions to form thiamin-like-phenol derivatives. Yields ranged from 50-70%, and Nuclear Magnetic Resonance (NMR) confirmed their structures. Anticancer activity was assessed by the National Cancer Institute. Separately, drug-resistant fungal infections, …

A Report Summarizing Hsc Faculty Participants: Ithaka S+R Coordinated Study Making Ai Generative For Higher Education, Laura J. Hall, Robyn Gleasner

Publications

This report presents findings from the University of New Mexico Health Sciences Center’s (HSC) participation in the ITHAKA S+R study Making AI Generative for Higher Education. Seven faculty members from HSC disciplines including internal medicine, pathology, psychiatry, nursing, radiology, and population health were interviewed to explore their perspectives on generative AI (GenAI) in teaching and learning, research and scholarship, and institutional support. A unique theme of “practice” emerged, reflecting how GenAI is influencing clinical care, bench-to-bedside translation, and the preparation of students for future professional practice. The report highlights faculty experiences, ethical concerns, and support needs, offering insight into how …

Understanding And Intervening In Children's Tick Risk Perceptions And Protective Behaviors: A Grounded Theory, Ariel Dawdy

Department of Entomology: Dissertations, Theses, and Student Research

Children, ages 8 years and younger, are at a particularly high risk of contracting a tick-borne disease. This is partially due to the misconceptions spread about tick protective behavior and a poor understanding of how antibiotic treatment can help. Because most communities and families believe that tick control is the individual’s responsibility, looking at the interaction between ticks and human children is essential to understanding the individual’s motivations to protect themselves. To help alleviate the number of individuals contracting tick-borne diseases, misconceptions must be addressed, intervention programs implemented, and a behavioral change must occur. This study used a qualitative research …

Soybean Cyst Nematode (Heterodera Glycines Ichinohe) Virulence Assay Against Resistance Sources In Nebraska, Pratibha Karki

Department of Plant Pathology: Dissertations, Theses, and Student Research

Soybean cyst nematode (SCN, Heterodera glycines Ichinohe), one of the major yield-limiting pathogens of soybean, is currently found in 60 counties of Nebraska that produce more than 90% of the state’s soybean. Often, yield loss occurs without any above-ground symptoms, which makes it difficult to manage. The primary management option is the use of SCN-resistant varieties. Several soybean plant introductions serve as resistance sources against SCN. Unfortunately, the single source, PI 88788, is used in approximately 90% of resistant varieties and its prolonged use has increased the virulence status of SCN in the U.S. A study was conducted to assess …

Analysis Of Impulsive Differential Equation Models Of Cell Populations Undergoing Radiation Therapy, Abigail D'Ovidio Long

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Radiation therapy is a mode of treatment which is implemented for approximately 50% of cancer patients. Treatment needs to be able to kill cancer cells, but also do minimal damage to surrounding healthy tissue. We propose two main impulsive differential equation models of radiation therapy to capture the periodic nature of the treatment. These models build off of previous studies using clinical data to ensure biological relevance. The first model incorporates only cancer cell populations, and we provide parameter relationships which theoretically ensure treatment outcomes of cancer eradication, cancer approaching a carrying capacity, and cancer approaching a periodic solution. We …

Local Rural Knowledge And Early Childhood Informal Science Education In Rural Nebraska, Sarah Michelle Paulos

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This study aims to discover the existing experiences that lead to local rural knowledge (LRK) of specific rural Northeast Nebraska communities. This information will assist in understanding the impact that LRK has on young children’s science knowledge in rural communities. By engaging in hands-on experiences and interactions, science learning goals for children may be achieved and developed through science outreach programs. During Phase 1 of this study, adults in the selected rural communities participated in an online survey indicating their knowledge of various common rural phrases with the option to share personal stories of experiences and family history. This information …

Characterization Of The Final Enzyme In The Coenzyme M Biosynthesis Pathway In Methanosarcina, Connor John Hines

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Methanogenesis is known to be one of the oldest forms of energy generation on our planet. Methanogens rely on this method of energy conservation and have evolved to metabolize a variety of substrates, including the waste products of other organisms. This feature has made methanogens beneficial to both wastewater treatment and landfill-to-energy projects. Methane itself is a greenhouse gas twenty times more potent than carbon dioxide, viewed as a particularly influential contributor to global greenhouse emissions. Climate change was known to be on the horizon throughout the 20^th century but has made itself known vocally during this 21^{st …}

Variable Selection In Distance Metric Learning And Triplet Constraints For Deep Learning Based Ordinal Classification, James D. Clothier

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The purpose of this research is to augment linear and kernelized ordinal distance metric learning (L/KODML) techniques with a proposed variable selection methodology that integrates the Sequential Multi-Response Feature Selection (SMuRFS) algorithm. Additionally, we aim to embed ordinal triplet constraints into a deep learning architecture, and to propose a general framework for deep learning-based ordinal classification. A variety of simulation studies and real data experiments were conducted to evaluate the various methodologies. For the distance metric learning and variable selection, results showed that the integration of SMuRFS performed effective variable selection and improved prediction accuracy. For the triplet constraints, incorporating …

Novel Mouse Models To Study The Role Of T Cells In Cardiac Autoimmunity, Meghna Sur

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Myocarditis patients can chronically develop dilated cardiomyopathy and autoreactive T cells could contribute to the disease pathogenesis, but defining their antigen specificity remains a major challenge. To fill this gap, we generated T cell receptor (TCR) transgenic (Tg) mice specific to cardiac myosin heavy chain (Myhc)-α 334–352 and made a few observations. First, we unexpectedly noted both CD4 and CD8 T cells expressing TCRs specific to Myhc-α 334–352. Second, while Tg T cells from myocarditis-resistant C57BL/6J mice did not respond to Myhc-α 334–352, those from immunized mice responded, indicating that in vivo priming is necessary to break tolerance. Third, upon …

Performance Of Acoustic Telemetry And Space Use Of Pallid Sturgeon In The Lower Platte River, Nebraska, Christopher F. Pullano

School of Natural Resources: Dissertations, Theses, and Student Research

Pallid Sturgeon (Scaphirhynchus albus) are centenarian, potamodromous, rheophiles that historically occupied the Missouri River and Mississippi River basins. Listed on the U.S. Endangered Species Act in 1990, population declines are attributed to habitat fragmentation and degradation, as well as overharvest, and hybridization. A knowledge gap exists regarding the extent to which tributaries facilitate key life stages for Pallid Sturgeon. This study evaluated the capacity of acoustic telemetry to monitor the movements of Pallid Sturgeon in a shallow, braided tributary to the Missouri River. The specific objectives were to (1) evaluate the environmental variables influencing the performance of acoustic …

Occupancy Of Fish Species Of Greatest Conservation Need And Temporal Patterns Of Assemblage Occurrence In Sandhills Ecoregion, Nebraska Streams, Braxton M. Newkirk

School of Natural Resources: Dissertations, Theses, and Student Research

Fish species’ occurrence is influenced by environmental conditions across multiple spatial and temporal scales. Alteration to stream systems has the potential to affect occurrence patterns of fish species. Stream systems of the North American Great Plains face threats originating from climate change and anthropogenic activities resulting in negative implications for many fish species. The Sandhills Ecoregion, Nebraska is considered one of the largest intact grasslands in North America, and thus may experience fewer threats than surrounding areas. Stream systems of the Sandhills Ecoregion are home to 12 fish species of greatest conservation need (SGCN). Little context exists regarding the environmental …

Spatial Ecology Of American Bison On Vermejo Park Ranch, New Mexico, Kate Ann Asmus

School of Natural Resources: Dissertations, Theses, and Student Research

American bison (Bison bison) are a keystone species that impact grassland productivity, plant diversity, and landscape heterogeneity. We used GPS telemetry and a replicate herbivore grazing experiment on Vermejo Park Ranch in northeastern New Mexico to advance understanding of bison spatial ecology and grazing dynamics. First, we evaluated the potentially disparate influences of forage productivity and site fidelity on the size and selection of home ranges of bison. Home range size was strongly negatively influenced by forage productivity. However, home range selection was influenced more strongly by site fidelity than spatial variation in forage, as bison selected home …

“Being With God”: Prayer Biographies, Mysticism In Old Age, And Compassionate Love Among Older Jesuits, Stephen John Fogle

Gerontology Theses, Dissertations, and Student Creative Activity

This dissertation explores lived experiences of prayer and aging among older Jesuits from a religion, spirituality, and aging perspective in five chapters. Chapter One opens with a review of prayer in gerontological literature. The chapter recommends attention to prayer in life course perspective, details of prayer in old age as a relationship with divinity, and appreciation of religious and spiritual outcomes of aging. The chapter concludes with an overview of research with older Jesuits of the Upper Midwest. Chapter Two presents prayer biographies of older Jesuits in life course perspective. The chapter discusses how age stages, relationships, historical events, and …

A Review Of The Philosophy Of Flood Risk Communication And Education: New Insights Informed By Critical Complexity, Timothy Lutz

Earth & Space Sciences Faculty Publications

The approach to flooding in the U.S. is strongly influenced by research and practices that place the responsibility for managing risk on scientific and technical experts. But there is a recognition that the public generally needs to be more engaged and responsible. There is currently a disconnect between the objective knowledge of experts and the more subjective ways in which people experience floods and flood risk. To bridge this gap, I start with a review of the philosophy that informs government policies and the societal worldview. While societal leaders have maintained a mechanistic vision of a world that is ultimately …

The Genomic Basis Of Adaptation In Salt-Marsh-Breeding Sparrows, Jonathan David Clark

Doctoral Dissertations

Salt marshes are an ecotone between terrestrial and marine environments characterized byshort, graminoid vegetation and periodic tidal inundation with saline water. Despite the generally inhospitable conditions salt marshes present for terrestrial vertebrate life—principally, exposure to heat, salinity, and flooding—several terrestrial vertebrate species have adapted to, or are capable of inhabiting salt marshes. Notably, species of passerine birds that have adapted to salt marshes have repeatedly evolved a similar suite of adaptations, which has been named the “saltmarsh syndrome,” including larger bills, darker plumage, and an increased tolerance of salt.

The myriad species of New World sparrows (Passerellidae) that breed in …

Climate Change In New England: The Influence Of Soil Warming And Nitrogen Enrichment On Forest Carbon Cycling, Thomas Joseph Muratore

Doctoral Dissertations

Forests, the largest active cycling reservoir of carbon (C) in the terrestrial biosphere, mediate the exchange of CO2 between the atmosphere and the biosphere in large enough quantities to affect Earth’s climate. Presently, forests are significant C sinks and mitigate one-third of all anthropogenic C emissions by storing more C in biomass and soils than they exchange with the atmosphere. Anthropogenic activities and climate change disrupt the balance between forest C uptake and loss. This raises concerns about the sensitivity of the forest C sink. Traditionally, forest C exchange between trees and soils under climate change has been studied separately, …

“Why You Understand The Why”: A Qualitative Characterization Of The Metacognitive Competence Of Introductory Stem Peer Coaches, Jonathan Kustina

Doctoral Dissertations

The processes of metacognition are vital for students’ development of critical thinking skills and productive learning mindsets, yet many students never receive the direct instruction that would allow them to formally develop their metacognition. As instructors are typically not providing this instruction, there may be an alternate source to facilitate the learning of metacognition to students. This research study will investigate the viability of having peer coaches, undergraduate peer educators who help facilitate learning and problem solving in introductory STEM courses, facilitate metacognition to their students. Specifically, this research study aims to understand and characterize the metacognitive competence of the …

Functional Characterization Of Copper Tolerance In The Atypical Microsymbiont Pseudofrankia Inefficax, Megan Paige Garcia

Doctoral Dissertations

Bacterial species in the family Frankiaceae are soil-dwelling microsymbionts that form a mutualistic symbiosis, termed the actinorhizal symbiosis, with over 220 species of woody dicots. In this relationship, frankia fix atmospheric nitrogen to ammonia, a form usable by plants, while the bacteria benefit from the carbon sources exuded by their actinorhizal hosts. Since nitrogen is typically a limiting nutrient for growth in degraded and contaminated soils, actinorhizal plants establish at these sites as pioneer plant species, initiating a path for phytoremediation. Likely due to their association with plant hosts in contaminated soils, most frankia strains have evolved above average tolerances …

Improving Understanding Of Fluvial Reach-Scale Solute Transport And Uptake Using A Particle Tracking Model And Random Forest Machine Learning Model, Jiaying Liu

Doctoral Dissertations

In addition to transporting flowing water, river systems carry dissolved nutrients and pollutants, which can experience chemical reactions, biological uptake, or retention in surface or hyporheic zones. This dissertation enhances our understanding of solute transport and uptake in river reaches through three main components. The first component involves the development of a novel curve-fitting model designed to capture the characteristics of pulse-release breakthrough curves (BTCs) from tracer studies with conservative solutes. The model, which was found to be applicable to a wide range of field studies, enables the rapid comparison of transport parameters among diverse field studies obtained under a …

Deformation-Induced Bonding Of Glassy Polymeric Films And The Diluent Effect, Ajay Vallabh

Doctoral Dissertations

Bonding between two polymer films can be achieved through various heat- or chemical-based methods. Recently, our group has discovered the novel phenomenon of deformation-induced bonding (DIB) for solid-state glassy polymers in time on the scale of a fraction of a second at ambient temperatures substantially below the bulk glass transition temperatures (T_g). DIB is achieved by bulk plastic compression, which triggers the molecular mobility of polymer chains to cause interpenetration across the interface even in a glassy regime.

First, we performed a series of experiments to evaluate solid-state, deformation-induced bonding in organic polymer blends composed of films of hydroxypropyl methylcellulose …

A Funerary Rite: A Visual Ethnography Of Climate Change, Threatened And Endangered Coral Species, And The Impact Of Coral Reef Death On Coastal Communities, Jason Uhl

Theses

This directed project includes research on a selection of the 24 coral species currently listed as threatened or endangered, these being at high risk of extinction. Climate change of the Anthropocene era and associated human-induced pollution impacts have resulted in most of the Earth’s coral reefs experiencing increased coral bleaching and coral death events. Our planet’s coral reefs are the main habitat to 25% of the world’s fish population. These coral habitats have also supported innumerous coastal communities in cultural, economic, social, and spiritual respects for millennia. This directed project includes the creation of an exhibition of 22 lidded ceramic …

An Extensive Exploration Of Generalist Microbotryum Species Through Host Interactions., Emilee Walters

College of Arts & Sciences Senior Theses

The Microbotryum species complex is a group of fungi, commonly known as anther smuts. Anther smuts are plant parasites that must invade a host plant in order to fulfill their life cycle. As the Microbotryum fungus grows, it sterilizes the host plant, such that infected plants produce fungal teliospores instead of pollen on the male reproductive organs and female reproductive structures do not mature. Microbotryum usually exists as a specialist species, however, there is evidence that several species of anther smuts can exist as generalist species. Comparisons of the infection process and the resulting response of both parasite and host …

Addressing The Public Health Concern Of Maternal Mortality In Houston, Texas, Lucy Couture

Dissertations and Theses (Open Access)

Maternal mortality remains a pressing public health concern in the United States, with disproportionate consequences for marginalized communities. Despite being a developed nation, the U.S. reports one of the highest maternal mortality rates among its peers, with approximately 80% of maternal deaths deemed preventable. Texas reflects this national crisis, particularly affecting Black women, whose maternal mortality rate is significantly higher than that of other racial and ethnic groups. This thesis explores maternal mortality trends in Houston, Texas, analyzing the roles of systemic inequities, social determinants of health, and disparities in access to quality care. Drawing on data from the Texas …

Induced Systemic Resistance Against Nematodes By Plant Growth-Promoting Microbes In Potatoes, Cole Grannan

Master's Theses

Biofertilizers consist of plant growth-promoting microorganisms that establish symbiotic relationships with plant roots and stems. These beneficial microbes play a crucial role in enhancing plant defenses against various threats including insects, nematodes, and microbial pathogens. The purpose of this study was to investigate the effectiveness of two fungal biofertilizers (an endophytic strain of Beauveria bassiana (BA) and a mixture of arbuscular mycorrhizal (AM) fungi), specifically their ability to induce systemic resistance against plant- parasitic nematodes (PPNs) in potatoes (Solanum tuberosum cv. Masquerade) under controlled greenhouse conditions. The study utilized soil collected from Colorado State University’s San Luis Valley (SLV) Research …

Rape Beyond Fantasy: Exploring The Influence Of Booktok's Erotica And Dark Romance Literature On Young Adult Perceptions Of Consent And Boundaries, Teagan Bailey Fortune

Master's Theses

Advances in technology and media, particularly TikTok, have had a significant impact on the younger generation. BookTok, a community that emerged from TikTok, is a platform where users can promote, share, and discuss book recommendations, using “spice level” or chili emojis to indicate the rating of explicit content. While recommendations often focus on erotica and dark romance fiction, concerns arise when such content glamorizes and normalizes rape culture, especially for young adults (YA). The normalization of toxic relationships can potentially influence YA perceptions of consent and boundaries. This study explores how YA perceive rape culture and consent in erotica and …

Leading Biologics In Pharmacy Practice: The Role Of Pharmacists, Amerah Elshayeb, Emily Austin, Lipika Chablani

Doctoral External Publications

Evaluate the current approaches to handling biologics, identify challenges associated with their storage and preparation, and emphasize the critical role of pharmacy education in ensuring safe and effective management of biologics.

Bad Plants, Heather I. Sullivan

Modern Languages and Literatures Faculty Research

“Bad plants” represent the seemingly unexpected and startling forms of plant power overlooked by many modern, industrialized societies that treat vegetal beings as mere resources instead of animate, world-shaping forces. Since science fiction and fairy tales often explore more openly animistic visions of non-human life, such texts provide ample possibilities for reconsideration by critical plant studies of our human-plant relations both cultural and ecological. For example, both Jack McDevitt’s 2001 science fiction novel, Deepsix, and Ludwig Tieck’s 1799 fairy tale, “Faithful Eckart and Tannhäuser”, feature “bad plants” that bring human beings violently back into the plant cycles they assume they …

Magnetic Resonance Imaging Trackable Pathology-Triggered Polymersomes Toward Enzyme Replacement Theranostics For Gm1 Gangliosidosis, Dorian Foster

All Dissertations

This dissertation investigates the development and optimization of pathology-responsive polymersomes for simultaneous enhanced magnetic resonance imaging (MRI) and enzyme replacement therapy (ERT) in the treatment of GM1 gangliosidosis (GM1). While therapeutic strategies exist for similar, non-neuropathic lysosomal storage disorders, implementation towards GM1 faces significant challenges due to the blood-brain barrier.

Herein, we developed and characterized a range of low molecular weight hyaluronic acid-b-polylactic acid (HA-PLA) polymersomes (PSs) capable of encapsulating therapeutic enzymes in their hydrophilic core. These polymersomes exhibit pathophysiology-triggered responsiveness, degrading in the presence of acidic conditions, which is characteristic of lysosomes, and enzymes such as hexosaminidase A, which …

Soil Data From Spring Run Conservation Area, Dayton, Ohio, Madelaine Gregory, Valerie N. Thurston, Michaela J. Woods, Ryan W. Mcewan

Data Files: Ecosystem Restoration Following Industrial Agriculture

This spreadsheet contains soil data from an experiment in the Spring Run Conservation Area in Dayton, Ohio, USA (39° 46 '42.2"N, 84° 20' 52.5"W). Details of the data collection can be found in the master's thesis "The State of Soil Streamlines Secondary Succession: Remediating Degraded Soils in a Post-Agricultural Field."

The Price Of Precision: Significant Figures And The Student Experience, Ryan Michael Britt

Dissertations

For students pursuing careers in medicine and science, general chemistry is often viewed as a gatekeeper course. Students struggle with general chemistry for a variety of reasons, one of the most common being mathematical difficulties. Compared to other lower division STEM courses, mathematical computation in general chemistry represents a unique challenge for the student due to the special emphasis placed on reporting answers to the proper degree of precision using significant figure (SF) rules. Although these rules feature in nearly every undergraduate chemistry course, their impact on the student experience of learning chemistry has never before been studied.

The purpose …