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Genetic Analysis Of A Novel Population Of Southern Flying Squirrels (Glaucomys Volans) Found In Lincoln, Ne, Jennifer Wettschreck Dec 2024

Genetic Analysis Of A Novel Population Of Southern Flying Squirrels (Glaucomys Volans) Found In Lincoln, Ne, Jennifer Wettschreck

Biology Theses, Dissertations, and Student Creative Activity

In 2018 a novel population of southern flying squirrels (Glaucomys volans) was discovered in Lincoln, Nebraska, 80 km outside of their known range. Southern flying squirrels are designated as a “Tier-1” species of concern within Nebraska and the origin of this new population is of interest to state biologists. This study will provide insight into the probable origin of this new population by comparing genetic samples from known populations of southern flying squirrels. Museum specimens were collected from two well-established populations in Florida and Texas, as well as samples from individuals native to Nebraska (Indian Cave State Park) to compare …


Investigating The Role Of Feature Integration Demands On Attention Efficiency., Emma Kurtycz Dec 2024

Investigating The Role Of Feature Integration Demands On Attention Efficiency., Emma Kurtycz

College of Arts & Sciences Senior Theses

Feature integration and visual selective attention have been studied together to understand how we attend to different objects, often through conjunction search tasks. Conjunction search tasks involve searching for an object defined by multiple visual features in the presence of distractors. However, few studies have examined how different visual feature combinations impact search performance. Motivated by the functional and structural organization of the brain, this study investigated how differing feature combinations that theoretically place varying degrees of demand on feature integration impact attention efficiency. In two experiments, I explored reaction times (RT) and target detection sensitivity (d’) across varying set …


Cultural Concepts Of Distress Education For Clinicians, Leilani Jolene Santos Cancio Dec 2024

Cultural Concepts Of Distress Education For Clinicians, Leilani Jolene Santos Cancio

Capstone Projects and Master's Theses

The Adult System of Care (ASOC) program at Monterey County Behavioral Health supports adults with mental health and co-occurring substance use disorders. Despite serving a diverse population, there is limited training that addresses the complex intersection of culture and mental health. This project involved a workshop for ASOC clinicians focused on cultural concepts of distress, specifically "ataque de nervios," a syndrome common in Hispanic and Latino individuals. The workshop aimed to enhance clinicians' understanding of how cultural identity impacts mental health symptoms. Pre and post-workshop surveys assessed knowledge gains. The project yielded positive outcomes, with clinicians gaining valuable insights into …


Soil Dynamics In Carbon, Nitrogen, And Enzyme Activity Under Maize–Green Manure Cropping Sequences, Cassio Hamilton Abreu-Junior, Wanderley José De Melo, Roberto Alves De Oliveira, Paulo Henrique Silveira Cardoso, Raíssa De Araujo Dantas, Rodrigo Nogueira De Sousa, Dalila Lopes Da Silva, Thiago Assis Rodrigues Nogueira, Arun Dilipkumar Jani, Gian Franco Capra, Gabriel Maurício Peruca De Melo Dec 2024

Soil Dynamics In Carbon, Nitrogen, And Enzyme Activity Under Maize–Green Manure Cropping Sequences, Cassio Hamilton Abreu-Junior, Wanderley José De Melo, Roberto Alves De Oliveira, Paulo Henrique Silveira Cardoso, Raíssa De Araujo Dantas, Rodrigo Nogueira De Sousa, Dalila Lopes Da Silva, Thiago Assis Rodrigues Nogueira, Arun Dilipkumar Jani, Gian Franco Capra, Gabriel Maurício Peruca De Melo

Biology, Agriculture and Chemistry Faculty Publications and Presentations

The diversification of cropping sequences has a positive impact on soil organic carbon, while improving nutrient cycling and crop yields. The objective of this research was to assess amylase, cellulase, C and N dynamics, and maize yield on a low fertility oxisol in the Brazilian Cerrado. The experiment was conducted under field conditions during three maize crop succession cycles. The treatments consisted of cultivating maize during the summer, after sorghum and lablab cropped as green manure and fallow during the winter. Higher maize yields were achieved by sorghum–maize succession compared to monocropping, due to higher N fertilizer and biomass inputs …


Characterization Of An Acetogenin-Carrying Nanosuspension And Its Effect On Bacteria Of Interest In The Poultry Industry, Brandon A. Lopez-Romero, Gabriela Aguilar-Hernandez, Billy M. Hargis, Maria De Lourdes Garcia-Magana, Ulises M. Lopez-Garcia, Rosa I. Ortiz-Basurto, Adalberto Zamudio-Ojeda, Juan D. Latorre, Efigenia Montalvo-Gonzalez Dec 2024

Characterization Of An Acetogenin-Carrying Nanosuspension And Its Effect On Bacteria Of Interest In The Poultry Industry, Brandon A. Lopez-Romero, Gabriela Aguilar-Hernandez, Billy M. Hargis, Maria De Lourdes Garcia-Magana, Ulises M. Lopez-Garcia, Rosa I. Ortiz-Basurto, Adalberto Zamudio-Ojeda, Juan D. Latorre, Efigenia Montalvo-Gonzalez

Poultry Science Faculty Publications and Presentations

This work aimed to develop a nanosuspension (NSps) as an acetogenin (ACGs) carrier, using soy lecithin (SL) and hydroxypropyl-β-cyclodextrin (βCD) named NSps-βCDSL-ACGs. It was characterized by various spectroscopic techniques (DLS, FTIR, UV-vis diffuse reflectance). Moreover, the NSps morphology was observed by transmission electron microscopy (TEM). Also, the antibacterial activity of NSps-βCDSL-ACGs was evaluated against strains of interest in the poultry sector. NSps-βCDSL-ACGs presented nanometric size (207–239 nm), acceptable polydispersity index (PDI) values (0.13–0.17) and a high Z potential value (−47.17–50.36 mV), demonstrating high stability. The presence of ACGs in NSps-βCDSL-ACGs was confirmed by FTIR analysis. The nanoparticles had a spherical …


Influence Of Hydrologic And Anthropogenic Disturbance On Stream Populations And Communities, Sarah Frances Sorensen Dec 2024

Influence Of Hydrologic And Anthropogenic Disturbance On Stream Populations And Communities, Sarah Frances Sorensen

Graduate Theses and Dissertations

Disturbances occur when an external force modifies a habitat, destroying living space, removing food resources, or altering or destroying habitat structure. In lotic systems, a primary source of disturbance is hydrologic disturbance, including drought and flood. Hydrologic disturbances lead to increased mortality rates and dispersal out of disturbed habitats, causing population sizes to decrease and changes to community structures. More research is needed on how disturbances impact stream species and communities, as disturbances are predicted to become more intense with climate change. This dissertation aims to understand how disturbance influences streams at both the population and community level, through a …


Frogs On A Plain: Spatial Ecology Of Crawfish Frogs In Arkansas’ Remnant Prairies, Elliot T. Lassiter Dec 2024

Frogs On A Plain: Spatial Ecology Of Crawfish Frogs In Arkansas’ Remnant Prairies, Elliot T. Lassiter

Graduate Theses and Dissertations

The prairie peninsula was an expansive and important habitat that covered much of midwestern North America, from Canada to Arkansas, USA. But the prairie peninsula has shrunk by as much as 99% since 1830, and therefore, land acquisition and public/private partnerships are critical for the preservation of prairies and their associated species. In Arkansas, one species that benefits from protected prairies is the Crawfish Frog (Lithobates areolatus), which is currently declining precipitously throughout its range. Adult Crawfish Frogs spend most of their lives in terrestrial refugia (crayfish burrows), making them highly vulnerable to habitat loss and fragmentation, thereby …


Integrating Sustainability And Food Safety Through Quantitative Microbial Risk Assessment And Life Cycle Assessment Of Low-Moisture Foods, Jessica Bain Dec 2024

Integrating Sustainability And Food Safety Through Quantitative Microbial Risk Assessment And Life Cycle Assessment Of Low-Moisture Foods, Jessica Bain

Graduate Theses and Dissertations

Food safety and sustainability are critical concerns in the food industry. However, these areas are often evaluated separately, leading to an incomplete understanding of the overall impact of food production on human health. This dissertation aims to integrate food safety with sustainability to provide a comprehensive assessment of the impact of low-moisture foods on human health, using the almond processing supply chain as a case study.

In addition to conducting life cycle assessments (LCA) of almond processing, wheat flour production, and dried apple processing, this dissertation aims to create a framework to bridge the gap between sustainability and food safety. …


Influence Of Head Sway On The Availability Of Visual Information In An Affordance Task, Ron Dickson Jr. Dec 2024

Influence Of Head Sway On The Availability Of Visual Information In An Affordance Task, Ron Dickson Jr.

Honors Theses

This thesis investigated how varying postural conditions and environmental challenges influence human affordance perception in virtual environments, focusing specifically on participants’ judgments about whether they could stand upright on sloped surfaces. Using virtual reality (VR) to simulate ramps at various inclines, participants assessed their ability to stand on these slopes under different postural constraints (unaided standing, leaning, and touch-supported). Data was collected on head movement dynamics, including movement magnitude, variability, and complexity, using measures such as Euclidean distance and effort-to-compress (ETC). Logistic and linear regression analyses revealed that slope angle and stance significantly impacted participants' affordance judgments and movement patterns, …


A Linguistic Analysis Of The Language Surrounding Witchcraft In France From The 16th To 20th Centuries, Kaleigh Landers Dec 2024

A Linguistic Analysis Of The Language Surrounding Witchcraft In France From The 16th To 20th Centuries, Kaleigh Landers

Honors Theses

While the history of witchcraft in France is a subject that has received significant scholarly attention, little research has been conducted on the linguistic implications of the language used in regard to the subject. This study attempts to analyze the texts written about witchcraft between the 16th and 20th centuries in order to draw conclusions as to how language and culture affect each other. The aim of this study was to conduct a discourse analysis of these texts to identify cultural connotations, language trends, and insights regarding how the French language has evolved to communicate complex, dividing concepts …


Downtown Hattiesburg: In History And Memory, Joseph Reosti Dec 2024

Downtown Hattiesburg: In History And Memory, Joseph Reosti

Honors Theses

This paper explores how public memory of Downtown Hattiesburg has been shaped by race, class, and historical change, drawing primarily on oral history interviews conducted by the author. Once the heart of the city, Downtown Hattiesburg experienced significant decline from the 1970s onward due to suburbanization, white flight, and demographic shifts. In response, the 1970s saw the emergence of a historic preservation movement focused on revitalizing memories of the city's early 20th-century prosperity (1910-1929), often idealized as a period of economic success even despite racial segregation. Many interviewees identified this era as the city’s "golden age," despite its deeply inequitable …


Exploring The Capabilities Of Classifier-Free Guidance In Recommendation Tasks, Noah Buchanan Dec 2024

Exploring The Capabilities Of Classifier-Free Guidance In Recommendation Tasks, Noah Buchanan

Graduate Theses and Dissertations

This thesis addresses the problem of recommending items to users based on their ratings of items through a diffusion recommender system. Regular recommender systems are already capable of efficient recommendation through conventional methods such as collaborative or content-based filtering. Diffusion is a new type of generative AI that aims to improve our previous AI's shortcomings in the generative domain, like Variational Autoencoders (VAEs) and Generative Adversarial Networks (GANs). We use diffusion to create a recommender system that mirrors the sequence users take when browsing and rating items. The current methods of recommendation with diffusion do not use the new innovation …


Synthesis Of Chemical Fuels And Feedstocks From Co2 For Extraterrestrial Applications, Samuel Keith Conlin Dec 2024

Synthesis Of Chemical Fuels And Feedstocks From Co2 For Extraterrestrial Applications, Samuel Keith Conlin

Graduate Theses and Dissertations

The reduction of CO2 into products for either the storage of renewable electricity or to act as a source of renewable feedstock for industry, is not economically feasible given the current costs of renewable energy. Significant amounts of work have gone into attempting to optimize both electrochemical and nonthermal plasma-based CO2 reduction systems in an attempt to reduce side reactions and improve energy efficiency in order to meet cost feasibility targets. These techniques can also be adapted for In-Situ Resource Utilization (ISRU) contexts, which are far less sensitive to the cost of renewable energy yet have more strenuous …


Multimodal Spectroscopy To Study Tumor Microenvironmental Changes In Vivo, April Mordi Dec 2024

Multimodal Spectroscopy To Study Tumor Microenvironmental Changes In Vivo, April Mordi

Graduate Theses and Dissertations

Every year there are millions of new cancer diagnoses and deaths worldwide. While great strides have been made in technologies and drugs for cancer treatment, there is still a need to understand tumor response to therapy as many patients still endure treatment failure after completing their treatment regimen. Current clinical imaging techniques for detecting response to therapy are utilized weeks to months after the course of treatment, and present limitations to measuring response during treatment. Optical spectroscopy techniques can help meet this need to determine the response of tumors to treatment as it allows for near real-time in vivo characterization …


Employee Development And Employee Resilience In The Post-Covid-19 Workplace: A Quantitative Study Of High School Educators, Amy Keiser Maffei Dec 2024

Employee Development And Employee Resilience In The Post-Covid-19 Workplace: A Quantitative Study Of High School Educators, Amy Keiser Maffei

Graduate Theses and Dissertations

The problem addressed by this research is the need for protective factors to support teacher resilience. Organizations that fail to develop employee resilience risk failing to enjoy the positive outcomes associated with it. Research-based methods to improve resilience may benefit organizations, including school districts. The purpose of this study was to examine the relationship between employee development provided by a school district and the resilience of its high school teachers in the post-Covid-19, in-person workplace. Conservation of Resources theory served as the framework to guide the research. Study participants completed a questionnaire with Likert-style response options, with items to assess …


Exploring The Interplay Between Testosterone Levels And Gender Role Attitudes, Arial Bloshinsky Dec 2024

Exploring The Interplay Between Testosterone Levels And Gender Role Attitudes, Arial Bloshinsky

Graduate Theses and Dissertations

Traditional gender role attitudes align men with resource management and women with nurturing. The Challenge Hypothesis proposes that resource management is associated with higher testosterone levels, whereas nurturing is associated with lower testosterone levels. Therefore, traditional gender role attitudes may be associated with people’s testosterone levels. Furthermore, during the transition to parenthood, traditional gender role attitudes may become particularly salient, as shifting biological, social, and cultural roles during this transition make these attitudes an integral part of daily life. In this longitudinal study of expectant couples, participants completed a baseline survey and baseline session, during which they completed measures and …


The Impact Of Wild Pigs (Sus Scrofa) On Avian Occupancy And Vegetation Structure, Kenneth Wilson Dec 2024

The Impact Of Wild Pigs (Sus Scrofa) On Avian Occupancy And Vegetation Structure, Kenneth Wilson

Graduate Theses and Dissertations

Invasive species, particularly wild pigs (Sus scrofa), pose a significant threat to native ecosystems through both direct and indirect impacts. Wild pigs are large-bodied omnivorous species that can consume a wide variety of plants and animals and are known for destructive foraging behaviors, which likely threatens avian communities through habitat alteration and can impact the long term structure of ecosystems where they are present.

In chapter 1, we used a combination of avian point count surveys, vegetation assessments, and camera trap surveillance to quantify how the occupancy of breeding birds in bottomland hardwood forests changed in relation to …


Synthesis And Process Optimization Of Cellulose Nanocrystals From Miscanthus X. Giganteus For Commercial Viability, Jaspreet Kaur Dec 2024

Synthesis And Process Optimization Of Cellulose Nanocrystals From Miscanthus X. Giganteus For Commercial Viability, Jaspreet Kaur

Graduate Theses and Dissertations

Cellulose nanocrystals (CNCs), derivatives of an abundant biopolymer, i.e., cellulose, are emerging as promising alternatives to petrochemical-based products due to their unique properties, including biodegradability, low toxicity, high strength, low density, large surface area and low coefficient of expansion. CNCs have diverse applications ranging from food packaging and textiles to drug delivery and medical implants, etc. Despite their potential, the widespread commercialization of CNCs faces significant hurdles owing to the high environmental burden and production costs. They are mainly driven by the commonly used source utilized for CNC synthesis i.e., wood and the intensive synthesis process i.e., requirement of …


Two-Photon Imaging For Characterizing Tumor Microenvironmental Changes In Non-Small Cell Lung Cancer Associated With Metastatic Recurrence, Paola Monterroso Diaz Dec 2024

Two-Photon Imaging For Characterizing Tumor Microenvironmental Changes In Non-Small Cell Lung Cancer Associated With Metastatic Recurrence, Paola Monterroso Diaz

Graduate Theses and Dissertations

Lung cancer remains the leading cause of cancer deaths, comprising nearly 25% of all cancer deaths (Sung et al., 2021a). The five-year survival rate of patients with non-small cell lung carcinoma (NSCLC) remains significantly low given that over half present with locally advanced or metastatic disease at time of diagnosis, and experience tumor recurrence following therapeutic intervention (Tamura et al., 2015; Uramoto & Tanaka, 2014). Current evaluation techniques to assess treatment response are lacking, given they are implemented several weeks after treatment completion and are solely based on anatomical changes in tumor size, forgoing other criteria such as functional or …


Causal Discovery In Time Series Data Using Deep Learning Techniques, Saima Zahin Farhana Absar Dec 2024

Causal Discovery In Time Series Data Using Deep Learning Techniques, Saima Zahin Farhana Absar

Graduate Theses and Dissertations

Causal structure learning from observational data has been an active field of research over the past decades. In the literature, different algorithms and models have been proposed, such as constrained-based methods and score-based methods including the emerging deep learning-based methods. However, most of the approaches apply to static and non-dynamic data only. In many applications, the data is temporal. For example, monitoring systems, weather surveillance systems, and stock data, to name but a few. Incorporating temporal information is an important extension of the causal discovery field. With the growth of observational data these days, the discovery of causal relationships from …


Carbon Dioxide Dynamics In The Carbonate Critical Zone, Savoy Experimental Watershed, Arkansas, Usa, Michael Darvin Jones Dec 2024

Carbon Dioxide Dynamics In The Carbonate Critical Zone, Savoy Experimental Watershed, Arkansas, Usa, Michael Darvin Jones

Graduate Theses and Dissertations

The dynamics of carbon dioxide (CO2) within the Earth’s critical zone (CZ) are essential for driving spatial and temporal variations of carbonate dissolution and precipitation, which are fundamental to subsurface porosity and permeability development. However, there is still a significant knowledge gap regarding the patterns of CO2 transport and production within the carbonate critical zone (CCZ). In this study, we investigated these dynamics within a mantled karst terrain at the Savoy Experimental Watershed (SEW) in Northwest Arkansas.

Previous monitoring of partial pressure of CO2 (PCO2) and dissolution rates at karst springs in …


Use Of Hatchery-Raised Fish In Validation Of Daily Age Estimates For Juvenile Common Snook, Philip W. Stevens, Kyle L. Williams, Meredith B. Pfennig, Ryan W. Schloesser, Alexis A. Trotter, Derek P. Crane Dec 2024

Use Of Hatchery-Raised Fish In Validation Of Daily Age Estimates For Juvenile Common Snook, Philip W. Stevens, Kyle L. Williams, Meredith B. Pfennig, Ryan W. Schloesser, Alexis A. Trotter, Derek P. Crane

Biology

Objective: We investigated the validity of daily age estimates for juvenile Common Snook Centropomus undecimalis by using sectioned and sanded sagittal otoliths. Methods: Common Snook have a protracted spawning season, which is problematic for validation of daily ages because a hatch date—needed to calculate age—cannot be reasonably assigned like it can for species with a short spawning period (<30 days). To help overcome this, two readers independently counted presumed daily increments in otoliths collected from hatchery-reared Common Snook of known age (100–240 days; n = 91). Result: Differences between known ages and those estimated from otoliths were small (mean absolute difference = 3.4 days) for individuals aged 100 days, but these differences increased after 100 days, mainly due to the crowding of increments along the otolith margin. Underestimation of ages was 8% at 120 days, 29% at 180 days, and 36% at 240 days. Conclusion: Ideally, analyses based on counts of daily increments in Common Snook otoliths should be limited to fish with an age of 100 days or younger.


Recreational Fishing For Western Rock Lobster: Estimates Of Participation, Effort And Catch In 2023/24, Claire B. Smallwood, Karina L. Ryan, Alissa C. Tate Dec 2024

Recreational Fishing For Western Rock Lobster: Estimates Of Participation, Effort And Catch In 2023/24, Claire B. Smallwood, Karina L. Ryan, Alissa C. Tate

Fisheries Research Reports

The Western Rock Lobster (WRL) (Panulirus cygnus) is the most commonly caught Rock Lobster (RL) species in Western Australia. Catches from the commercial and recreational sectors are required to determine and monitor Total Allowable Commercial Catch (TACC), Total Allowable Recreational Catch (TARC) and the proportion of Allowable Harvest Level (AHL) achieved. The TARC is set at 5% of the AHL and evaluated in the harvest strategy based on a 5-year average.

Data for the recreational sector are obtained using phone-recall surveys to provide annual estimates of participation, fishing effort and retained catch (by numbers) from recreational fishers who hold a …


Draft Assembly And Annotation Of The Cuban Crocodile (Crocodylus Rhombifer) Genome, Robert W. Meredith, Yoamel Milián-García, John Gatesy, Michael A. Russello, George Amato Dec 2024

Draft Assembly And Annotation Of The Cuban Crocodile (Crocodylus Rhombifer) Genome, Robert W. Meredith, Yoamel Milián-García, John Gatesy, Michael A. Russello, George Amato

Department of Biology Faculty Scholarship and Creative Works

Objectives: The new data provide an important genomic resource for the Critically Endangered Cuban crocodile (Crocodylus rhombifer). Cuban crocodiles are restricted to the Zapata Swamp in southern Matanzas Province, Cuba, and readily hybridize with the widespread American crocodile (Crocodylus acutus) in areas of sympatry. The reported de novo assembly will contribute to studies of crocodylian evolutionary history and provide a resource for informing Cuban crocodile conservation. Data description: The final 2.2 Gb draft genome for C. rhombifer consists of 41,387 scaffolds (contigs: N50 = 104.67 Kb; scaffold: N50-518.55 Kb). Benchmarking Universal Single-Copy Orthologs (BUSCO) identified 92.3% of the 3,354 genes …


The Effects Of Mosaicism On Biological And Clinical Markers Of Alzheimer's Disease In Adults With Down Syndrome, Laura Xicota, Lam-Ha T. Dang, Alice Lee, Sharon Krinsky-Mchale, Deborah Pang, Lisa Melilli, Sid E. O’Bryant, Rachel L. Henson, Charles Laymon, Florence Lai, H. Diana Rosas, Beau Ances, Ira Lott, Christy Hom, Bradley Christian, Sigan Hartley, Shahid Zaman, Elizabeth Head, Mark Mapstone, Zhezhen Jin, Wayne Silverman, Nicole Schupf, Benjamin Handen, Joseph H. Lee, Alzheimer’S Biomarker Consortium – Down Syndrome (Abc-Ds) Dec 2024

The Effects Of Mosaicism On Biological And Clinical Markers Of Alzheimer's Disease In Adults With Down Syndrome, Laura Xicota, Lam-Ha T. Dang, Alice Lee, Sharon Krinsky-Mchale, Deborah Pang, Lisa Melilli, Sid E. O’Bryant, Rachel L. Henson, Charles Laymon, Florence Lai, H. Diana Rosas, Beau Ances, Ira Lott, Christy Hom, Bradley Christian, Sigan Hartley, Shahid Zaman, Elizabeth Head, Mark Mapstone, Zhezhen Jin, Wayne Silverman, Nicole Schupf, Benjamin Handen, Joseph H. Lee, Alzheimer’S Biomarker Consortium – Down Syndrome (Abc-Ds)

Neurology Faculty Publications

Background Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer’s disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years or in their lifetime. Mosaicism could contribute to this phenotypic variation, where some disomic cells could lead to lower levels of gene products from chromosome 21.

Methods We examined longitudinal neuropsychological and biomarker data from two large studies of DS: the Alzheimer Biomarker Consortium–Down syndrome study (ABC-DS) (n = 357); and a legacy study (n = 468). We assessed mosaicism using karyotyping or GWAS data. Participants had data on plasma …


Training In Ecological Thinking: Narrative Practices For Educational Professional, Cristina Trovato Dec 2024

Training In Ecological Thinking: Narrative Practices For Educational Professional, Cristina Trovato

University of South Florida (USF) M3 Publishing

Since the 1970s, the issue of environmental education has assumed relevance in the context of a theory of training towards new forms of sustainability education. Literary ecology, a discipline born from the contamination of ecology and literature, proposes itself as a critical response to environmental distress, enhancing the implicit dialogue and interconnections between the text and the circumstances of the environment. The literary heritage constitutes a precious resource for promoting, in educational contexts from early childhood, dimensions that range from the cognitive to the emotional and for activating sustainable processes, through ecological paths that develop a civic conscience, capable of …


Targeted Long-Read Sequencing To Quantify Methylation Of The C9orf72 Repeat Expansion, Evan Udine, Nicole Finch, Mariely Dejesus-Hernandez, Jazmyne L. Jackson, Matthew C. Baker, Siva Arumugam Saravanaperumal, Eric Wieben, Mark T. W. Ebbert, Jaimin Shah, Leonard Petrucelli, Rosa Rademakers, Björn Oskarsson, Marka Van Blitterswijk Dec 2024

Targeted Long-Read Sequencing To Quantify Methylation Of The C9orf72 Repeat Expansion, Evan Udine, Nicole Finch, Mariely Dejesus-Hernandez, Jazmyne L. Jackson, Matthew C. Baker, Siva Arumugam Saravanaperumal, Eric Wieben, Mark T. W. Ebbert, Jaimin Shah, Leonard Petrucelli, Rosa Rademakers, Björn Oskarsson, Marka Van Blitterswijk

Neurology Faculty Publications

Background The gene C9orf72 harbors a non-coding hexanucleotide repeat expansion known to cause amyotrophic lateral sclerosis and frontotemporal dementia. While previous studies have estimated the length of this repeat expansion in multiple tissues, technological limitations have impeded researchers from exploring additional features, such as methylation levels.

Methods We aimed to characterize C9orf72 repeat expansions using a targeted, amplification-free long-read sequencing method. Our primary goal was to determine the presence and subsequent quantification of observed methylation in the C9orf72 repeat expansion. In addition, we measured the repeat length and purity of the expansion. To do this, we sequenced DNA extracted from …


Conceptualizing Centrality In Micro-Level Internationalization Through A Decolonial Approach, Omolabake Fakunle Dec 2024

Conceptualizing Centrality In Micro-Level Internationalization Through A Decolonial Approach, Omolabake Fakunle

Journal of Comparative & International Higher Education

Micro-level internationalization offers possibilities to explore different human experiences in international higher education. This is especially crucial given well-reported issues of racism, micro-aggression, and underrepresentation of racially minoritized international academic staff, whose voices remain mostly invisible in internationalization discourses. Previous research connects these issues to the continuing legacy of colonial logic, that privileges hegemonic Westerncentric knowledge systems. In this paper, centrality is proposed as a conceptual framework that offers a direct response to the question of epistemicide which Santos (2014) explains as the exclusion of the knowledges of racially marginalized persons [in or with origins] from the Global South. It …


Design And Synthesis Of Therapeutic Molecules Targeted At Metabolic Pathways Of Cancer And Lipid Signaling In Fungal Diseases, Jennifer Uzoamaka Nnaemeka Dec 2024

Design And Synthesis Of Therapeutic Molecules Targeted At Metabolic Pathways Of Cancer And Lipid Signaling In Fungal Diseases, Jennifer Uzoamaka Nnaemeka

All Theses

Cancer remains a leading cause of global mortality, with 20 million new cases and 9.7 million deaths recorded in 2022 (WHO, 2024). While advancements like nanoparticles and monoclonal antibodies offer new treatments, they often cause severe toxicity to normal cells. This study introduced novel thiamin-based compounds targeting enzymes critical for cancer cell proliferation. These compounds were synthesized via a three-step process involving tosylation, SN2 coupling with phenolic compounds, and subsequent reactions to form thiamin-like-phenol derivatives. Yields ranged from 50-70%, and Nuclear Magnetic Resonance (NMR) confirmed their structures. Anticancer activity was assessed by the National Cancer Institute. Separately, drug-resistant fungal infections, …


A Report Summarizing Hsc Faculty Participants: Ithaka S+R Coordinated Study Making Ai Generative For Higher Education, Laura J. Hall, Robyn Gleasner Dec 2024

A Report Summarizing Hsc Faculty Participants: Ithaka S+R Coordinated Study Making Ai Generative For Higher Education, Laura J. Hall, Robyn Gleasner

Publications

This report presents findings from the University of New Mexico Health Sciences Center’s (HSC) participation in the ITHAKA S+R study Making AI Generative for Higher Education. Seven faculty members from HSC disciplines including internal medicine, pathology, psychiatry, nursing, radiology, and population health were interviewed to explore their perspectives on generative AI (GenAI) in teaching and learning, research and scholarship, and institutional support. A unique theme of “practice” emerged, reflecting how GenAI is influencing clinical care, bench-to-bedside translation, and the preparation of students for future professional practice. The report highlights faculty experiences, ethical concerns, and support needs, offering insight into how …