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Identification Of Corrosion Damage, Vibration, And Loose Conections In Aircraft Data Transmission Lines Using Reflected And Transmitted Signals; Formulation Of Vegetable Oil-Based Nanofluids As Cutting Fluids For Mql Machining, Saidanvardzhon Valiev

Doctoral Dissertations

This research presents a novel Frequency Domain Transmitometry (FDT) method that uses transmitted signals (S21) to detect and characterize aircraft data transmission lines (ADTL) corrosion damage without additional reflectometry circuitry. Corrosion experiments were conducted according to ASTM G85-A5 over 14 weeks. Combined FDT and reflected signals (S11) analyses revealed distinct three-peak signatures associated with damage and corrosion. The square root of the Area Under the Curve (AUC) of the FDT damage peak and the Full Width at Three-Quarter Maximum (FW3QM) of the S11 damage peak is correlated with corrosion propagation depth and width. S11 signals were further used for vibration …

An Investigation Into How The Prostate And Androgens Mediate Greater Levels Of Uric Acid In Males Compared To Females, Rachel D. King

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chronic elevated circulating uric acid (UA) levels (hyperuricemia) are associated with gout as well as cardiovascular, metabolic, and renal dysfunction. Men have greater mean circulating UA levels than women and are more likely to exhibit hyperuricemia. This may be partly driven by the hormonal regulation of renal UA transporters; however, a direct link between hormones and UA production has not been established. Production of UA is catalyzed by xanthine oxidoreductase (XOR / XDH), which is ubiquitously expressed but has the greatest specific activity in the liver. Interestingly, an extensive gout genome-wide association study (GWAS) recently revealed a robust genetic …

Back To The Future Self: Parsing Age Effects In Future Self-Continuity Through Goal Orientation And Life Satisfaction, Laken A. Mooney

Graduate Theses, Dissertations, and Problem Reports (ETD)

Future self-continuity, the psychological feeling of connectedness between the current and the future self, is a relatively novel concept that is associated with and has been used to predict a variety of outcomes. Though work investigating individual differences is comparatively rare, a robust demographic difference found in previous literature is the presence of an age effect, where older adults are more likely to feel a greater connection to their future self than younger adults. This finding has been replicated a number of times, but potential mechanisms behind this observed age-related increase have yet to be fully uncovered. Limited previous work …

A Comparison Of Endodontic Root-End Filling Techniques: A Micro-Computed Tomography (Micro-Ct) Analysis Part Ii, Andrew M. Marra

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

A COMPARISON OF ENDODONTIC ROOT-END FILLING TECHNIQUES: A MICRO-COMPUTED TOMOGRAPHY ANALYSIS

Andrew Marra, D.D.S.

Introduction: Researchers have compared many endodontic root-end filling techniques for porosity, though few have used a micro-computed tomography analysis for comparisons. The purpose of this study was to evaluate total porosity volume of three different bio-ceramics filling materials with two techniques--hand compaction versus hand/ultrasonic compaction at an ultrasonic setting of 5% using Micro-CT Analysis.

Methods: Seventy-two human single canaled extracted teeth were selected for the study. All were subjected to orthograde endodontic treatment followed by root tip resection at 3-mm from the apex …

Social Support And Negative Affective Outcomes Among Older Adults: Does Valuing Autonomy Matter?, Erika Anne Fenstermacher

Graduate Theses, Dissertations, and Problem Reports (ETD)

While not a normal part of aging, depression is a concerning psychiatric condition in late life. Depression is a significant predictor of suicide and the highest rates of suicide occur in middle aged and older adult men. One factor that may protect against depression and suicidal behavior among older adults is social support. Social support has been demonstrated as a significant factor in health and well-being. Perceived social support has consistently been linked to beneficial outcomes, however, received support has mixed results with some studies even finding received support to be harmful. For individuals who highly value autonomy, it may …

Exploring The Ruminal Microbiome And Its Impacts On Feed Efficiency In Beef Cattle, Taylor Simone Sidney

Graduate Theses, Dissertations, and Problem Reports (ETD)

The ability for beef cattle to utilize feed efficiently is a critical determinant for both economic and environmental sustainability in livestock production. However, despite extensive research, the complex microbial ecosystem within the rumen and its relationship to feed efficiency remain incompletely understood. This dissertation explores the physiological and microbial foundations of feed efficiency by characterizing how rumen microbial communities and their functions differ among beef cattle with divergent residual feed intake (RFI) phenotypes and how the RFI status of beef cattle influenced their response to dietary interventions such as supplementation with a Bacillus-based feed additive. In the first study, …

Teachers’ Perspectives On Behavioral Classroom Expectations Of Students With Emotional And Behavioral Disorders, Jennifer E. Brewer

Theses and Dissertations

The problem addressed in this study was that adolescents with emotional and behavior disorders (EBD) were failing in general education courses. The purpose was to investigate how teachers’ perceptions and biases influenced EBD students. Participants included five teachers (two special education teachers and three general education teachers) from each of Grades 6, 7, and 8 recruited from social media. The study was guided by the case study research design, and the interview instrument was the Indepth Interview Protocol. Data analysis was guided by a coding system that facilitated searching the interview responses for themes.

Research Question 1 queried about forms …

Engineering Extracellular Vesicles (Evs) To Combat Infection And Inflammation In Cystic Fibrosis, Sharanya Sarkar

Dartmouth College Ph.D Dissertations

Cystic Fibrosis (CF) is a multisystemic genetic disorder caused by mutations in the CFTR gene, resulting in chronic pulmonary infections, hyperinflammation, and progressive lung damage. Among the pathogens that colonize CF lungs, Pseudomonas aeruginosa (P. aeruginosa) is predominant, infecting over 50% of adults with CF and developing antibiotic resistance over time. Current modulator therapies fail to address persistent bacterial infections, chronic inflammation, or irreversible lung damage, underscoring the need for novel therapeutic strategies. In our previous in vitro studies, we demonstrated that extracellular vesicles (EVs) secreted by primary Human Bronchial Epithelial Cells (HBECs) inhibit P. aeruginosa growth by reducing the …

Delayed Tooth Eruption As An Early Clinical Indicator Of Genetical Tooth Agenesis: A Family-Based Study Of Cases With Whole-Exome Sequencing, Yu-Chen Jeng, I-Ting Chen, Hui-Ching Cheng, Hsin-Yu Huang, Chao-Kai Hsu, Yu-Fen Yen

Journal of Dental Sciences

Delayed tooth eruption is frequently considered a benign developmental variation but may represent an early sign of genetically driven tooth agenesis. We evaluated a 22-month-old female presenting with markedly delayed eruption (only eight primary teeth) and a positive family history of ectodermal features. Given the inconclusive early radiographic findings, whole-exome sequencing (WES) was utilized. WES revealed the proband carried a heterozygous EDARADD variant (NM_080738:c.328G>T; p.Asp110Tyr). Subsequent familial segregation analysis identified an additional heterozygous WNT10A variant (NM_025216:c.637G>A; p.Gly213Ser) within the broader family. The EDARADD variant alone was associated with varying presentations from normal dentition to delayed eruption. Furthermore, the …

A Scientometric Study On Research Trends And Characteristics Of Tooth Intentional Replantation, Yan Zhou, Simin Deng, Wenhua Xu, Wei Liu, Yibo Guo, Mingyi Zhu

Journal of Dental Sciences

Background/purpose: Intentional replantation is regarded as a final strategy to preserve natural teeth affected by inaccessible endodontic and periodontal disease. The purpose of this study was to analyze the scientometric characteristics and research trends of tooth intentional replantation.

Materials and methods: All the papers on intentional replantation were comprehensively retrieved from the Scopus database. The years of publication were divided into before 2017 and after 2017 in the analysis of research trends.

Results: There were 356 papers on intentional replantation, with total citations of 5562 and the h index of 42. The trend of bone substitutes, boron …

Dance Improvisation And Kinematics: Describing Spontaneous Motion Among Movers, Fallon Simone Doshi Brackley

Student Scholarship

No abstract provided.

Development Of An Enantioselective Synthesis Of (–)-Euonyminol And Studies Towards The Total Synthesis Of (–)-Lomaiviticin A, Zhi Xu

Yale Graduate School of Arts and Sciences Dissertations

In the first chapter, I describe the development of the first enantioselective synthesis of (–)-euonyminol (1), a heavily oxidized sesquiterpenoid. Structurally, (–)-euonyminol (1) features a tricyclic framework containing an all-carbon quaternary center and nine free hydroxyl groups. Following the initial failed attempts to achieve a semi-pinacol rearrangement of an allylic silyl ether, we developed a novel oxyalkylation reaction to establish the C10 quaternary center of 1. From this intermediate, we investigated three distinct strategies to construct the tricyclic framework of 1 employing a reductive cyclization, an aldol–dehydration sequence, and a radical cyclization reaction, respectively. Finally, a series of stereoselective transformations …

'Typical Cases': Representation, Racializing Medicine, And The Politics Of The Case Study In The Moulages Collections Of The Hôpital Saint-Louis, Kathleen Pierce

Art: Faculty Publications

Physicians at the hôpital Saint-Louis prized their collection of wax models (moulages) for their precise representation of color: a central project of dermatology. Close looking at the collection, however, reveals the repeated use of a consistent light skin tone across the vast majority of models. Given physicians’ investment in chromatic precision, how might we understand this generic attention to skin coloration? “Typical Cases” asks how, when, and why skin pigmentation mattered to fin-de-siècle dermatologists. I first argue that the overrepresentation of light skin tones comprises an aesthetic choice made by the model-makers and their physician-patrons. I subsequently ask how this …

Beyond The Glass Ceiling: Career Advancement Strategies For Mid-Level Women In Student Affairs, Jalonda N. Thompson

Journal of Higher Education & Student Affairs

The purpose of this paper is to provide an overview of the literature on the push and pull factors that influence women’s choices to either opt in or opt out of career advancement in student affairs (Coetzee & Moosa, 2020; Harman & Sealy, 2017). Women, specifically Black women, are underrepresented in Senior Student Affairs Officer (SSAO) positions in higher education (American Council of Education, 2024). As the demographics of the United States (US) change, student affairs is at a critical point to foster an inclusive learning environment that reflects the increasing racial and ethnic diversity in the US (Lopez, 2006). …

Effect Of Creatine Monohydrate On Spatialworking Memory, Body Weight, And Food Intake In Male And Female Rats, Cyrilla H. Wideman, Alexandria Iemma, Olivia Janolo, Anastasiya Kalinina, Helen M. Murphy

2025 Faculty Bibliography

Background/Objectives: Creatine monohydrate supplementation has gained popularity in the fitness industry due to its ability to enhance athletic performance and has sparked curiosity about other possible effects of the supplement. The purpose of this study was to examine the effect of creatine supplementation on spatial working memory, body weight, and food intake in male and female rats.

Methods: Experimental rats, six male and six female, were administered creatine while six male and six female rats served as controls. The Morris water maze (MWM) was employed to assess spatial working memory. Body weight and food intake were measured daily.

Results: Neither …

Functional Trait Responses Of Invasive Ludwigia Species Tocontrasting Hydrological Conditions, Rebecca E. Drenovsky, Rebecca Reicholf, Caryn Futrell, Blanca Gallego‐Tévar, Brenda J. Grewell

2025 Faculty Bibliography

Premise: Hydrological regime influences wetland plant species distribution andperformance. Global warming and extreme weather events are magnifying floodingpatterns, and understanding how invasive taxa respond across life stages (establish-ment vs. established phase) is important for predicting and managing their coloni-zation and spread. Our objective was to measure flood trait responses at contrastinglife stages in closely related congeners (Ludwigia peploides, diploid; L. hexapetala,decaploid; Onagraceae) differing in their invasiveness in the field.

Methods: In the field, we assessed phenological responses to seasonal hydrological changes,and in mesocosms, we assessed flood stress responses of establishing shoot fragments underdeep‐flooded, shallow‐flooded, and gradual drawdown hydrological …

Spatial Variation In Sexual Size Dimorphism And Mating Associations In The Color Polymorphic Eastern Red-Backed Salamander (Plethodon Cinereus), Maggie M. Hantak, Olivia L. Brooks, Kyle M. Brooks, Carl D. Anthony, Cari-Ann M. Hickerson, Kelly A. Williams, Shawn R. Kuchta

2025 Faculty Bibliography

Sexual selection due to mate preference for certain traits can maintain phenotypic diversity within populations and species. In taxa with discrete phenotypes, such as color polymorphic species, assortative mating may lead to disruptive selection and sympatric divergence, yet how such interactions vary over species' ranges remains poorly understood. To address this shortcoming, we examined spatial patterns of sexual size dimorphism and presumptive male–female mating pairs based on body size and coloration in the color polymorphic Eastern Red-backed Salamander, Plethodon cinereus. This species exhibits two common color morphs, striped and unstriped, that also differ in other elements of their biology, including …

Functional Trait Responses Of Emergent And Free-Floating Alternanthera Philoxeroides To Increasing Salinity With Sea Level Rise: Stress Tolerance, Avoidance, And Escape Strategies, Brenda J. Grewell, Blanca Gallego-Tevar, Jesus M. Castillo, Caryn J. Futrell, Rebecca E. Drenovsky, Nathan E. Harms, Paul D. Pratt

2025 Faculty Bibliography

ea level rise is having major impacts on estuaries due to salinity intrusion. These changes in stress profiles have ripple effects in ecosystems, including altering the invasibility of these wetlands depending on the salt tolerance of the invading species. Alternanthera philoxeroides Mart. (Griseb.) (alligator weed), native to South America and long recognized as one of the world’s worst freshwater aquatic weeds, recently invaded tidal wetlands in California’s San Francisco Bay–Delta Estuary. Generally considered a freshwater-limited glycophyte, observations suggested this invasive macrophyte may have some degree of salinity tolerance, though its degree of tolerance and capacity to spread with increased salinity …

The Assessment Of Morphological, Anatomical, And Phylogenetic Relationships Of Three Helicid Snails In Egypt, Sheriene E. Ali, Amina M. Ibrahim, Eman T. Hussien, Irene S. Gamil, Reda M. Mansour, Mostafa Y. Morad

Trends in advanced sciences and technology

Land snails provide valuable models for eco-genetic research because of their morphology and banding variability. Snails have shown unusually high intraspecific variation in anatomical traits leading to confusion for taxonomical studies, although their taxonomic resolution is low specifically in Egypt. This study aims to investigate the morphological, anatomical, and phylogenetic relationships for the first time among the snails Eobania vermiculata, Eremina desertorum, and Helix aspersa within the family Helicidae. The morphological indices revealed similarities among E. vermiculata, E. desertorum, and H. aspersa, However, SEM examinations indicated that the marginal teeth of the radulae in E. vermiculata and H. aspersa were …

Effects Of Single-Cell Dietary Protein Sources On Feeding, Growth, And Resource Allocation In The Juvenile Sea Urchin Lytechinus Variegatus, Darrien Jamila De Jesus

All ETDs from UAB

An understanding of nutrition can improve culture of sea urchins, whether as a research model or in the production of seafood products. Macronutrients, including dietary protein sources, can affect growth and reproductive profiles and alter resource allocation to somatic and gametic tissues. Although sea urchins in culture can be fed natural products, diet formulations using various ingredients can be developed to reliably produce desired outcomes. Single-cell protein sources represent a potential alternative to current industry standards of animal-derived protein sources such as fish and squid meal, which are becoming increasingly overfished and expensive. In the present study, we evaluated the …

Targeting The Thyroid-Stimulating Hormone Receptor (Tshr) In Thyroid Cancer, Grayson Robert Gimblet

All ETDs from UAB

Radioactive iodine (RAI) has been effective in the treatment of thyroid cancer, the most common endocrine neoplasia, since its introduction into clinical use over eighty years ago. However, not all patients benefit from RAI. Up to 20% of patients with well-differentiated thyroid cancer (WDTC) become radioactive iodine refractory (RAI-R). These RAI-R patients have 5-year survival rates of 50% and 10-year survival rates of 10%. In addition, more aggressive subtypes including oncocytic thyroid carcinoma (OC), poorly differentiated thyroid carcinoma (PDTC), and anaplastic thyroid carcinoma (ATC) are less responsive to RAI therapy. Despite accounting for less than 5% of annual thyroid cancer …

Electrophysiological Integration Of Engineered Tissue Graft With The Host Swine Myocardium, Bijay Guragain

All ETDs from UAB

The adult mammalian heart lacks regenerative capacity to replenish cardiomyocytes (CMs) lost due to myocardial infarction (MI). Instead, the damaged heart undergoes extensive remodeling that significantly impairs normal cardiac function and may eventually lead to heart failure. Recent therapies that implant engineered tissues fabricated from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have shown promising results with improved cardiac function and structural integration. However, the extent of electrophysiological coupling between engineered and host tissue remains unclear. This is a critical factor for functional integration of the implant as well as for arrhythmia risk arising from the implant. Our study aims …

The Role Of Aquaporin-3 Lysine 282 Acetylation In Renal Water Balance, Nha Van Huynh

All ETDs from UAB

Aquaporin-3 (AQP3) mediates basolateral water transport in the kidney collecting duct principal cells, contributing to vasopressin-mediated urine concentration. We previously identified a novel post-translational modification of AQP3, the acetylation of lysine 282 (K282), which we hypothesized as a positive regulator of AQP3 water permeability. First, we found that collecting duct K282 acetylated AQP3 increased upon water deprivation, suggesting an involvement in renal water balance. To decipher the functional role of this modification, we utilized AQP3 acetylation (K282Q or Q) and deacetylation (K282R or R) mimetic mutant mice models generated using CRISPR/Cas9 knock-in technology. Both male and female wild-type (WT) and …

Mechanoactivation Of Vegfr-2 Promotes Angiogenesis In The Tumor Microenvironment, Bronte Johnson

All ETDs from UAB

Cancer progression relies on blood vessel growth; without vasculature, tumors would be limited to less than 200µm in diameter. With this reasoning, several cancer therapies have been developed that target the process of angiogenesis, or the growth of vessels off pre-existing vasculature. These treatments target the major promoters of angiogenesis, vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR-2); however, anti-angiogenic therapies are not effective by themselves. This is likely due to mechanoactivation of VEGFR-2 through physical alterations in the tumor microenvironment (TME). One prevalent mechanical change is increased strain on surrounding cells and matrix due to highly contractile …

In Pursuit Of Sovereignty: Transformations Of Colonial Medicine From Wilhelmine To Nazi Germany, Veda Joshi

All ETDs from UAB

After the Berlin Conference of 1884-1885, the Great Powers of Europe, including the newly-born German Empire, greatly expanded their influence and colonial possessions in Africa, with colonies in East Asia and the South Pacific quickly following suit. The German Empire, like its contemporaries, engaged with medicine as a necessary part of its colonial endeavors in order to keep both its native laborers and European settlers healthy. Using documents from the German Bundesarchiv (Federal Archive), including official reports made to the German Colonial Office and documenting of formally conducted expeditions, as well as the writings of colonial doctors, this research examines …

Investigating The Role Of Notch1 On Cell Viability In Pancreatic Neuroendocrine Tumor Cells In Hypoxia, Alexis Kennedy

All ETDs from UAB

INVESTIGATING THE ROLE OF NOTCH1 ON CELL VIABILITY IN PANCREATIC NEUROENDOCRINE TUMOR CELLS IN HYPOXIA ALEXIS KENNEDY MULTIDISCIPLINARY BIOMEDICAL SCIENCE ABSTRACT Pancreatic neuroendocrine tumors (PNETs) are rare neoplasms originating from neuroendocrine cells in the pancreas. Patients with advanced disease pose a complex challenge due to poor prognosis and limited treatment options. Notch signaling is a juxtracrine cell-cell communication mechanism whereby transmembrane Notch receptors (Notch 1-4) interact with neighboring cells through ligands binding, resulting in a cascade that regulates various developmental processes and cell fate decisions. Dysregulated Notch1 signaling is implicated in PNETs, affecting neuroendocrine tumor biology and potentially interacting with …

Endothelial Cell Cd36 In Alzheimer’S Disease And Breast Cancer Progression, Atul Kumar

All ETDs from UAB

Vascular endothelial cells (ECs) are increasingly recognized as a distinct class of innate immune cells, with CD36, an innate immunity receptor, playing a pivotal role in regulating immune function and its regulation, angiogenesis, cancer progression, brain related disorder as well as the exchange of nutrients and waste. To investigate this further, we developed EC-specific CD36 knockout mice using the translating ribosome affinity purification (TRAP) technique. By isolating ribosome-bound mRNA directly from vascular endothelial cells in vivo in these knockout and control mice, we conducted deep RNA sequencing and transcriptional profiling. Our findings revealed that CD36 deficiency in brain endothelia led …

Young Adult Chronic Disease And Midlife Subjective Well-Being And Mental Health: Does Social Milestone Achievement Mediate The Link?, Hannah M. Lindl

All ETDs from UAB

Nearly one-in-four young adults ages 18-34 have a chronic disease, which has been linked to worse midlife mental health. Prior studies have little-examined the mechanism behind this association. The life course perspective suggests that because chronic disease in young adulthood is an unexpected and “off-time” event it may disrupt the achievement and timing of key social milestones. Inability to achieve or perceived delays in achieving the social markers of adulthood (e.g., completing school, homeownership, marriage) may therefore lead to worse midlife mental health. To address this proposition, I used panel data from the Youth Development Study (YDS and multivariate regression …

Molecular Imaging Of Triple-Negative Breast Cancer: Characterization And Modulation Of The Tumor Microenvironment, Shannon E. Lynch

All ETDs from UAB

Triple-negative breast cancer (TNBC) is an aggressive, heterogeneous subset of breast cancer which currently has no targeted therapies available due to lack of molecular therapeutic targets. Importantly, various radiopharmaceuticals can be imaged via positron emission tomography (PET) to quantify cellular and molecular features of the tumor microenvironment including glucose metabolism, receptor status, and immune activation. Somatostatin receptor subtype 2 (SSTR2) is G-protein coupled receptor overexpressed in neuroendocrine tumors (NETs) which can be imaged and targeted for theranostics via FDA-approved radiotherapy. SSTR2 expression is increased in hormone positive breast cancer but is expressed at low or variable levels in TNBC. However, …

A Lament For The Perishing Barbarians Of Edith Wharton’S Summer, Anna Marsh

All ETDs from UAB

This thesis considers Edith Wharton’s Summer through a Darwinian perspective. Wharton studied Darwin’s works extensively, so applying The Descent of Man to Summer’s communities has merit. Specifically, I consider Darwin’s writings on evolution as evolution may be altered by feelings of sympathy. In Summer, it is sympathy, loyalty, and ultimate benevolence for one’s people that furthers community evolution as a whole. This relationship between sympathy and community evolution seems to be one Wharton focuses on in Summer. The urban communities of Wharton’s novel pretended to be the most civil and therefore the most evolved, but it is their Mountain neighbors …