Digital Commons Network^™

Measuring Achilles Tendon Stiffness And Kinetics In-Vivo, Chloe L. Pinkston

Honors Undergraduate Theses

This study aims to measure the gastrocnemii Achilles subtendon passive stiffness and energy storage during walking. Stiffness was first determined using a noninvasive method that combines ultrasound, motion capture, musculoskeletal modeling, and a force transducer. Eight healthy participants were tested using this method to obtain the passive force-displacement relationship of the Achilles tendon at two different knee angles to calculate stiffness of the gastrocnemii subtendon. A gait analysis session was then performed using ultrasound, motion capture, and an instrumented treadmill at self-selected slow, normal, and fast walking speeds, using stiffness to calculate the subtendon’s force and energy storage. Gastrocnemii Achilles …

Comparative Efficacy Of Hallucinogens In Treating Mood Disorders Through A Meta-Analysis Of Symptom Reduction, Dosage, And Duration, John Marco D.F. Muniz

Honors Undergraduate Theses

Background: Hallucinogens including psilocybin, lysergic acid diethylamide (LSD), ketamine, N,N-dimethyltryptamine (DMT) (as ayahuasca), have re-emerged as potential rapid-acting treatments for mood disorders. We conducted a meta-analysis of placebo-controlled trials evaluating their efficacy in depression and anxiety disorders. Methods: A systematic review identified 12 trials (Total ≈ 670) meeting inclusion criteria (randomized, placebo-controlled). Data on Cohen’s d and Hedges’ g effect sizes for depression- and anxiety-related outcomes were extracted. We computed pooled effect sizes (weighted by sample size and inverse variance), performed subgroup analyses by drug, diagnosis, follow-up duration, and outcome measure type, and assessed heterogeneity (I², Q …

Effect Of Metal Ions On The Reactive Oxygen Species Scavenging Capabilities Of Cerium Oxide For Biological Applications, Agastya Mittal

Honors Undergraduate Theses

Ceria nanoparticles' capabilities to defend cells against oxidative stress through superoxide dismutase activity are well-documented. Ceria nanoparticles demonstrate a ratio between 3⁺/4⁺ oxidative states on the surface of the particles to exhibit oxygen vacancies, a feature that allows these particles to scavenge Reactive Oxygen Species (ROS) in times of Oxidative Stress. Oxidative stress arises from many wounds in the body, such as wounds in the skin, and can have significant impacts on the health of an individual. Even when receiving treatment for the skin wound, ROS can circulate from around the wound, be generated from an imbalance …

Optimization Of L-Citrulline Production In Corynebacterium Glutamicum, And The Effect Of The Human Small Intestine Environment, Simran S. Ghulldu

Honors Undergraduate Theses

L-citrulline is a crucial amino acid involved in nitric oxide production, which supports cardiovascular health, physical performance, and intestinal well-being. Nitric oxide deficiency is linked to conditions like hypertension, highlighting the need for efficient L-citrulline production. This study attempts to enhance L-citrulline synthesis in Corynebacterium glutamicum, a bacterium widely used in industrial amino acid production, as well as test a The hypothesis is that overexpressing carAB, which encodes carbamoyl phosphate synthetase, will increase carbamoyl phosphate levels and boost L-citrulline production. Two C. glutamicum strains were used: a wild type and the CRBG strain, which has mutations that promote …

Synthesis And Characterization Of Multifunctional Cerium Oxide Containing Nanoparticles For Biomedical Applications, Ishaan Patel

Honors Undergraduate Theses

This study presents the synthesis and comprehensive characterization of a novel core-shell nanoparticle composed of a maghemite (γ-Fe₂O₃) core and a europium-doped cerium oxide (EuCNP) shell, developed for potential use in cancer theranostics. Using a co-precipitation method, Fe₂O₃–EuCNP core-shell nanoparticles were synthesized and compared against control samples of CNPs, EuCNPs, and Fe₂O₃. A variety of characterization techniques, including UV-Vis spectroscopy, fluorescence spectroscopy, TEM, XRD, XPS, DLS, TGA, and DSC confirmed the successful synthesis of core-shell architecture and europium doping. Moreover, Fe₂O₃–EuCNPs demonstrating strong colloidal …

Investigating The Role Of Prostasin In Angiogenesis: A Chorioallantoic Membrane Model Approach, Zaima Aline

Honors Undergraduate Theses

Prostasin, also known as PRSS8 or CAP1, is a glycosylphosphatidylinositol (GPI)-anchored extracellular serine protease involved in various physiological and pathophysiological processes. Prostasin expression is observed during key phases of trophoblast invasion and placental development, critical steps in embryo implantation in Rhesus monkeys. This suggests a role for prostasin in extracellular matrix remodeling and tissue invasion, both essential for a healthy pregnancy. Moreover, prostasin appears vital for development as studies in mice show that a germline knockout of the gene leads to significant placental defects and eventual embryonic death, highlighting its importance in vascular and structural development within the placenta.

Building …

Examining The Effect Of A High Fat Diet On The Expression Of Adipokines In A Murine Model Of Barrett's Esophagus, Saagar A. Shah

Honors Undergraduate Theses

Chronic acid reflux results in injury to the esophagus and the development of Barrett’s Esophagus (BE). BE elevates the lifetime risk for a patient to develop Esophageal Adenocarcinoma (EAC). Clinically, one of the main risk factors for BE and EAC is obesity, which alters the secretion of inflammatory cytokines by adipocytes, also referred to as adipokines. Conflicting reports have been made to the expression of adipokines and their receptors in the progression to esophageal cancer. Utilizing an inflammation-based mouse model for BE, we hypothesize that alterations in the expression of adipokines and their receptors favor an inflammatory environment associated with …

Unravelling The Role Of Two-Component Systems In Mycobacterium Abscessus, Andrea C. Molero Perez

Honors Undergraduate Theses

Mycobacterium abscessus (Mab) is an emerging pathogen within the nontuberculous bacteria (NTM) which poses a threat due to its complex multi-drug resistance and opportunistic nature. It is predicted that only 45.6% of patients will have successful treatment, with immunocompromised and cystic fibrosis patients being the most threatened. Moreover, investigating new treatment approaches is key to responding to this public health issue. Two-component systems (TCS) are regulatory pathways that play a pivotal role in bacterial survival and virulence. These systems are composed of a sensor histidine kinase (HK) and cognate response regulator (RR) protein that senses environmental cues and triggers specific …

Utilizing Pneumatic Artificial Muscles To Simulate Wingbeat Kinematics For Morphing Uav Wings, Vireli S. Anbarasu

Honors Undergraduate Theses

The controlling muscles of a bird wing change stiffness and length to provide high efficiency when executing a flight maneuver. This variable stiffness allows the muscles to cycle between increasing energy, transmitting it, and restoring it, allowing an overall increase in mechanical and aerodynamic efficiency. Inspired by this, we have developed a system that uses pneumatic artificial muscles (PAMs) to actuate a morphing wing. The stiffness in the PAMS can be controlled to mimic the changes bird flight muscles undergo when executing a forward flapping maneuver. We will evaluate the performance of the PAMs in actuating a morphing wing through …

The Relationship Between Autistic Features And Identity Development Processes Among College Students Through An Intersectional Lens, Alejandra Santana

Honors Undergraduate Theses

Research on autistic features and identity development has indicated that autistic traits are positively associated with identity disturbance (Ratner & Berman, 2015). Characteristic attributes of autism, including circumscribed interests and impairments in social relatedness, align with self-rumination and hardships engaging in the components of identity formation (Gotham et al., 2014). Nonetheless, research on this topic remains scarce. The present study analyzed the association between autistic features and identity formation processes while considering sociocultural factors, such as gender conformity and social camouflaging. A sample of college students enrolled in a large metropolitan city (N = 427) was recruited to complete …

The Role Of Social Media And Acculturation In Body Comparison, Body Dissatisfaction, And Eating Pathology Among Hispanic And Latinx Individuals, Mariana Ortega

Honors Undergraduate Theses

Eating disorders are a group of mental health conditions that are characterized by complex etiologies. The development of eating disorders varies across each individual and their personal background. The current study examined the relationship between levels of acculturation and daily social media use on the presence of body comparison, body dissatisfaction, and eating pathology in Hispanic and Latinx individuals. The aim of this study is to investigate how these factors may lead to a unique etiology of disordered eating, specific to this ethnic group. The current study consisted of two phases. The first phase determined participant eligibility by confirming ethnic …

Healing Through Art: An Exploration Of Art History Influences On Contemporary Art Therapy For Practices In Oncology Care, Nicole Van

Honors Undergraduate Theses

Art therapy has emerged as a vital practice in oncology, offering patients a means of emotional expression and healing during their treatment journey. This project will explore how integrating art history into therapeutic settings, particularly through virtual classes, enhances the emotional well-being of cancer patients. By examining the impact of engaging with historical artworks, this research aims to illustrate how these artistic narratives can facilitate self-consciousness and foster flexibility in individuals facing significant health challenges. Research indicates that exposure to art can evoke emotion and promote psychological healing, serving as a therapeutic outlet for patients. This study will synthesize therapeutic …

Evaluating Coffee And Caffeine Intake In Adults With Cardiovascular Disease: A Comparative Literature Review, Adam Harrington

Honors Undergraduate Theses

Coffee is among the most commonly consumed beverages worldwide, and its bioactive components, including caffeine, affect the cardiovascular system through multiple physiological mechanisms. Patients with cardiovascular disease are typically advised to limit coffee and caffeine consumption because of potential cardiovascular harm, but emerging research challenges this recommendation. This review evaluates recent evidence regarding consumption of whole coffee, caffeine, or decaffeinated coffee in adults with established cardiovascular disease. Database searches conducted across three platforms for studies published after December 2021 yielded 360 records. Following screening against inclusion criteria, 11 studies were reviewed included in the final review. The studies showed variable …

Continuous Monitoring Of Sterility: Bacterial Contamination And Disinfectant Performance In Dental Clinics, Nathaly Alsalloum, Tarek Aboajwa, Shuaib Alahmad, Nermin Almouhammad

International Arab Journal of Dentistry

Objectives: This study aimed to (1) evaluate contamination levels across three clinics (endodontic, extraction and surgery, and fixed prosthodontics), (2) identify the types and prevalence of bacteria, (3) estimate the effectiveness of a commercial disinfectant, and (4) determine the bacterial species most responsive to the disinfectant.

Methods: Equal surfaces (17.98 cm²) were swabbed, cultured on nutrient agar for the total aerobic microbial count before and after disinfection, and analyzed using settle plates. Bacterial identification was conducted through colony characteristics, Gram staining, and biochemical tests. Data were processed using SPSS version 26.

Results: The endodontic clinic exhibited …

Evaluation Of Microtensile Bond Strength Of Composite Under Three Aging Conditions: A Comparative In Vitro Study, Fadi Hammoud, Louis Hardan, Maryse Nassif, Tala El Ghoul, Georges Najjar, Cynthia Kassis

International Arab Journal of Dentistry

Objectives: To investigate the effects of different in-vitro artificial aging protocols on the micro tensile bond strength (µTBS) of composite restorations applied to dentin.

Methods: A total of 88 teeth were prepared on dentin and divided into three distinct aging conditions and a control group : G1) Control group with no aging (n=22); G2) Thermal Cycling (Thermocycling) involving 10,000 cycles between 5°C and 55°C, with a dwell time of 20 seconds (n=22); G3) Mechanical Loading (Cyclic loading) with a 50 N load, a frequency of 1.5 Hz, and 10,000 cycles (n=22); G4) Combined Thermo-mechanical cyclic loading (TMCL) using …

Patient-Related And Tooth-Related Factors As Predictors For Tooth Loss In Periodontitis Patients: A Systematic Review, Cleane Daraze, Carole Chakar, Abdelrahman Kassir, Charbel Anka, Jean-Marie Megarbane

International Arab Journal of Dentistry

Introduction: The treatment of periodontitis aims to prevent further disease progression, to minimize symptoms and perception of the disease, possibly to restore lost tissues and to support patients in maintaining a healthy periodontium. Management of chronic periodontal disease requires a combination of therapeutic modalities and a lifelong commitment to periodontal self-care.

Objectives: The aim of this study is to evaluate predictors for tooth loss in patients previously diagnosed with periodontitis. This systematic review covers studies of over 10 years of follow up.

Methods: Electronic literature search was conducted on 19/02/2024 by one author across several databases, including …

The Swiping Desire: Intimacy, Libidinal Capitalism, And The Digital Subject In The Tinder Swindler, Chanif Ainun Naim

Masyarakat: Jurnal Sosiologi

This article examines how dating applications operate as libidinal infrastructures that restructure and commodify intimacy within platform capitalism, using The Tinder Swindler as a cultural case study. Employing a visual-narrative approach within the framework of Critical Discourse Analysis, the film is analyzed to reveal the structural exploitation of user affect and desire. Grounded in Lacanian psychoanalysis and Baudrillard’s simulation theory, the study argues that these platforms capitalize on the subject’s ontological lack (manque) which fuels desire as the desire for the Other’s desire. This psychic lack sustains a perpetual pursuit of recognition that can never be fulfilled. The swindler’s hyper-curated …

Genomic And Metabolic Network Properties In Thermophiles And Psychrophiles Compared To Mesophiles, Amal Saeed Alblooshi

Theses

Thermophiles and psychrophiles are extremophilic microorganisms that thrive in harsh conditions. Thermophiles are mostly located in hot springs, prosper in high temperatures. Psychrophiles thrive in extremely cold environments, including polar regions and deep-sea habitats. Although they play a crucial role in biotechnology and environmental research, their mechanisms of adaptation are still not well understood. The main objective of this thesis is to understand the genomic characteristics and metabolic network features in thermophiles and psychrophiles compared to mesophiles. The genomes of 59 species among thermophiles, psychrophiles, and mesophiles were collected from the NCBI database. These genomes were used to analyze their …

Barriers To Healthcare Utilization Among Undergraduate Students: A Gender Identity Perspective, Akhila Damarla

Honors Undergraduate Theses

The transition to college can be a crucial period of one’s life as one gains new and increased responsibilities, including managing their own healthcare. Although campus health services are available, undergraduate students have been found to often underutilize these resources due to barriers such as financial instability, lack of insurance, and identity-based disparities. While examining the current literature on this topic,there is a gap in exploring how the role of gender identity interacts with these barriers. This study addresses this gap by analyzing secondary data from the American College Health Association’s National College Health Assessment (ACHA-NCHA). Results revealed that transgender …

Florida’S Gifted Education Program: Exploring The Nexus Between Giftedness And Choice Of College Major, Sterlin L. Bass

Honors Undergraduate Theses

Florida’s Gifted Education Program (FGEP) is a K-12 educational program in Florida’s public education system through which gifted students are identified and supported through individualized educational plans promoting intellectual development. The intent of this study is to explore the influence Florida’s Gifted Education Program has on the choice of major of a student and mental health outcomes. Current data revolving around different definitions of “giftedness” such as high ACT scores, SAT scores, and GPA, show a connection between negative mental health outcomes produced by the development of perfectionism. FGEP presents challenges in addressing these concerns due to non-standardized curricula across …

Facilitation Of Chemotherapy Efficacy Through Targeted Drug Delivery In Lung Cancer Cells Via Ultrasound And Implications On Health Interventions, Ibrahim Nasim

Honors Undergraduate Theses

Lung Cancer (small cell and non-small cell) is the leading cause of cancer death in the US, accounting for about 20% of all cancer deaths. Paclitaxel (PTX) is a chemotherapeutic agent commonly used to treat lung cancer. It works by slowing and stopping cancer growth by stiffening microtubules within cells, promoting mitotic halt and cell death. Carboplatin (CP) is another agent given to lung cancer patients containing platinum and works via direct damage of oncolytic DNA. The exact mechanism of how PTX and CP cause cell death is still an under-studied area. This thesis aims to provide insight into how …

Investigating The Effect Of Artificial Sweeteners On Fitness And Metastasis In Drosophila Melanogaster, Om R. Patel

Honors Undergraduate Theses

Artificial sweeteners are widely used sugar substitutes, yet their potential effects on health remain poorly understood. For example, more evidence suggests that frequent consumers of sugar substitutes may also be at increased risk of excessive weight gain, metabolic syndrome, and type 2 diabetes, which contradicts the original purpose of artificial sweeteners. This thesis investigates the impact of artificial sweeteners on health using Drosophila melanogaster as a model organism, focusing on three key areas: viability, excretion, and cancer metastasis. Viability assays revealed that flies exposed to artificial sweeteners exhibited a decrease in progeny, with some concentrations increasing progeny but most decreasing …

Post-Translational Modification Of The Low-Density Lipoprotein Receptor By Serine Proteases, Matthew E. Ruiz

Honors Undergraduate Theses

Hypercholesterolemia is a disease affecting many Americans and adults worldwide and can lead to further complications such as atherosclerosis, stroke, or pulmonary embolisms making it a major risk factor for heart disease. The disease states are caused by chronically elevated levels of VLDLs that get broken down into LDLs. Cells expressing the LDLR can endocytose LDLs from the blood for use intracellularly as cholesterol and prevent plasma cholesterol deposition in the endothelium. Current treatments include leading healthier lifestyles through dieting and exercise, or pharmacological treatments targeting cellular cholesterol production or dietary cholesterol uptake from the GI tract. The SREBPs are …

The Effects Of Probiotics As A Complementary Treatment In Recurrent Bacterial Vaginosis And Vulvovaginal Candidiasis In Women: A Systematic Review, Luisana Rodriguez

Honors Undergraduate Theses

Vaginal infections such as Bacterial Vaginosis (BV) and Vulvovaginal Candidiasis (VVC) affect women globally, causing not only significant uncomfortable physical symptoms, psychological distress, and economic burden but also health complications that can have important repercussions later. Despite the standard treatment of using antifungals or antibiotics, recurrency is a prominent issue, which brings using probiotics as a complementary therapy to restore the vaginal microbiome and prevent another episode. This systematic review evaluates the efficacy of probiotics as a complementary treatment to reduce the recurrence rates of BV and VVC, as primary adjuncts to conventional therapies, or as a standalone option.

A …

Threading The Needle: Chinese American Adoptees And The In-Between, Annalee Johnson

Honors Undergraduate Theses

Threading the Needle is a short documentary that investigates the relationships between Chinese American adoptees, their families, and their heritage. The film features two primary participants, Mia Nails and Annalee “AJ” Johnson as they reflect on their Asian American identity, experiences with racism, and their struggles with cultural estrangement. The similarities and differences in their perspectives shed light on both the wonderful and the heartbreaking circumstances of adoption. The contemporary value of the film lies in how it challenges popular representations of the Asian American experience: Though in recent years, Asian American media has become more present in popular culture, …

Mental Illness Identity And Social Media Use In Generation Z, Tobey Smith

Honors Undergraduate Theses

The present study investigated factors that predict a high degree of mental illness identity among Generation Z college students. Specifically, the author aimed to evaluate social media use and other psychosocial factors, including social isolation, self-esteem, well-being, discrimination, and attitude toward recovery. Two-hundred and seventeen participants were recruited using SONA and social media. Participants completed scales to measure the variables of interest: Illness Identity Questionnaire - Mental Health, Rosenberg Self-Esteem Scale, Warwick-Edinburgh Mental Well-being Scale, Hope and Coping in Recovery Scale, Cornwell Perceived Isolation Scale, Stigma Scale, Social Media Use Scale, and a set of demographic questions. Pearson bivariate correlations, …

Improving Safe And Effective Management Of Pain At Home, Alayna V. Olivarez

Honors Undergraduate Theses

Pain is the most common clinical symptom in individuals with a cancer diagnosis. Additionally, home is the preferred place for cancer care which introduces numerous challenges for cancer pain management. The primary purpose of this literature review is to identify support interventions to enhance pain control, prevent exacerbations in pain, and optimize quality of life in individuals with cancer transitioning from the acute care setting to home. The secondary purpose of this review is to analyze patient-specific barriers influencing self-efficacy of pain management and overall health outcomes in the target population. A systematic literature search was conducted using CINAHL, EBSCOhost, …

Navigating Online Dating: Exploring The Intersection Of Attachment Styles, Parental Attachments, And Sociosexuality In Online Dating Among College Students, Jensley Velez-Lozada

Honors Undergraduate Theses

The aim of this thesis is to explore the connection between attachment styles, parental attachment, and sociosexuality as predictors of online dating attitudes among college students. As society navigates this new digital era of online dating, how does it continue to transform young adults as they form romantic and sexual connections? It becomes increasingly important to understand the psychological mechanisms that influence these behaviors. This study examined how anxious and avoidant attachment styles, parental attachment, and sociosexuality may have contributed to online hookup attempts and outcomes behaviors. It also examined how these variables interacted and influenced both the likelihood of …

The Effects Of Demographic Variables On Covid-19 Attitudes Surrounding The 2020 Election, Shelby K. Dalbec

Honors Undergraduate Theses

The COVID-19 pandemic was a worldwide phenomenon, with far-reaching consequences in all sectors of society, including the 2020 election. To better understand the implications of this global occurrence, this research examines the extent to which demographic variables influenced public opinions surrounding the COVID-19 pandemic. This study takes a quantitative approach, analyzing datasets from the 2020 American National Elections Studies (ANES). It examines demographic, socioeconomic, and political factors as independent variables, with dependent variables that capture attitudes related to the COVID-19 pandemic. I hypothesized that there would be a strong relationship between party identification and COVID-19 attitudes. This study found that …

How Does The Modern Supreme Court Treat The Idea Of Retribution In The Context Of Capital Punishment?, Paige Forsberg

Honors Undergraduate Theses

This thesis explores the modern U.S. Supreme Court's treatment of retribution in the context of capital punishment, analyzing how justices have framed and justified the death penalty as a form of justice. Through the examination of key Supreme Court rulings and legal arguments, this study evaluates the evolving role of retribution in the Court’s decisions on death penalty cases, highlighting how judicial reasoning has shifted over time in response to legal, philosophical, and societal developments.

Retribution, long considered one of the primary justifications for capital punishment, is examined through a nuanced lens in this study. While historically viewed as a …