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Bs Wildlife, Fisheries, And Conservation, Fisheries 2025-26, Arkansas State University - Jonesboro
Bs Wildlife, Fisheries, And Conservation, Fisheries 2025-26, Arkansas State University - Jonesboro
Bachelor of Science and Education
No abstract provided.
Bs Engineering Technology, Technical 2025-26, Arkansas State University - Jonesboro
Bs Engineering Technology, Technical 2025-26, Arkansas State University - Jonesboro
Bachelor of Science and Education
Technical Studies Emphasis
Bs Environmental Science, 2025-26, Arkansas State University - Jonesboro
Bs Environmental Science, 2025-26, Arkansas State University - Jonesboro
Bachelor of Science and Education
No abstract provided.
Bs Biotechnology, 2025-26, Arkansas State University - Jonesboro
Bs Biotechnology, 2025-26, Arkansas State University - Jonesboro
Bachelor of Science and Education
No abstract provided.
Bs Biological Science, Pre-Professional 2025-26, Arkansas State University - Jonesboro
Bs Biological Science, Pre-Professional 2025-26, Arkansas State University - Jonesboro
Bachelor of Science and Education
No abstract provided.
Development Of Self-Healing Polymer From Bio-Based Benzoxazine Blend With Poly(Ethylene Glycol) For Anti-Biofouling Applications, Pharaporn Yodkum
Development Of Self-Healing Polymer From Bio-Based Benzoxazine Blend With Poly(Ethylene Glycol) For Anti-Biofouling Applications, Pharaporn Yodkum
Chulalongkorn University Theses and Dissertations (Chula ETD)
Biofouling remains a significant challenge in marine industries, as conventional coatings often lose their antifouling efficacy once they become damaged. Incorporating self-healing capabilities into antifouling coatings has therefore emerged as a promising strategy to extend service life and maintain long-term performance. In this study, self-healing polymers were developed based on a bio-derived benzoxazine resin (E-fa), synthesized from renewable precursors including eugenol (a phenol source), furfurylamine (an amine source), and paraformaldehyde, and subsequently blended with poly(ethylene glycol) (PEG). The blends were formulated with varying weight ratios (95/5, 90/10, 85/15, and 80/20 wt/wt%) and PEG molecular weights (PEG-600, PEG-1500, and PEG-4000). This …
Comparative Analysis Of Gut Microbiota In Post-Mortem Chronic Alcoholics Versus Minimal To No Alcohol Users In The Thai Population, Laiba Pervez
Chulalongkorn University Theses and Dissertations (Chula ETD)
Chronic alcohol consumption induces long-term disruption of the gut microbiota, contributing to inflammation, metabolic imbalance, and impaired intestinal integrity. This study investigated 24 postmortem gut microbiota samples from the Thai population, including 12 chronic alcoholic and 12 non-alcoholic cadavers, focusing on cecal and fecal samples to identify site-specific microbial signatures of alcohol-associated dysbiosis. Following DNA extraction, the V3–V4 regions of the 16S rRNA gene were sequenced on the Illumina MiSeq platform. Data were processed in QIIME for OTU clustering and taxonomic profiling. Alpha (Shannon, Chao1, ACE) and beta (Bray–Curtis) diversity were analyzed with PERMANOVA (p< 0.05) while LEfSe, cladogram, and STAMP analyses identified differentially abundant taxa.. At the phylum level, alcoholic cecal samples (AC) showed a decrease in Firmicutes (59.07%) and increases in Proteobacteria (5.54%), Fusobacteria (8.48%), and Actinobacteria (2.78%) compared with controls (NAC). The rise in Actinobacteria was statistically significant. The class Bacilli was also elevated, reflecting a more oxygenated and inflammatory intestinal environment. At the genus level, Paeniclostridium was enriched in alcoholics, while the butyrate-producing Coprococcus was reduced, suggesting impaired SCFA metabolism and gut barrier function. In fecal samples (AF vs NAF), phylum-level differences were minimal, although Clostridium sensu stricto 1 was notably higher in alcoholics, consistent with inflammation-associated dysbiosis. When comparing gut regions, distinct spatial heterogeneity was observed. Within the alcoholic group, Firmicutes were more abundant in cecum, while Actinobacteria were lower compared to feces. Among controls, Actinobacteria and Bacteroidetes were enriched in feces, whereas Firmicutes predominated in the cecum. Alpha diversity analysis using ACE and Chao1 indices showed significant differences between cecal and fecal samples of the control group. Overall, postmortem gut microbiota retained distinct alcoholassociated signatures, with the cecum preserving clearer microbial patterns than feces. These findings highlight the cecum’s potential as a reliable site for detecting alcohol-related dysbiosis in forensics.
ผลของโปรแกรมเสริมสร้างความรอบรู้ด้านสุขภาพผ่านไลน์แอปพลิเคชันต่อพฤติกรรมการจัดการตนเองด้านการบริโภคอาหารในผู้ป่วยภาวะกล้ามเนื้อหัวใจขาดเลือดเฉียบพลันที่มีโรคร่วม, สุนิษา ละดา
Chulalongkorn University Theses and Dissertations (Chula ETD)
การวิจัยแบบกึ่งทดลองนี้มีวัตถุประสงค์ เพื่อศึกษาผลของโปรแกรมเสริมสร้างความรอบรู้ด้านสุขภาพผ่านไลน์แอปพลิเคชันต่อพฤติกรรมการจัดการตนเองด้านการบริโภคอาหารในผู้ป่วยภาวะกล้ามเนื้อหัวใจขาดเลือดเฉียบพลันที่มีโรคร่วม เบาหวาน ความดันโลหิตสูง ไขมันในเลือด 1 โรคขึ้นไป ที่มีอายุตั้งแต่ 35 – 80 ปี คัดเลือกกลุ่มตัวอย่างแบบเฉพาะเจาะจง แบ่งเป็นกลุ่มควบคุมและกลุ่มทดลอง กลุ่มละ 23 คน จับคู่ทั้งสองกลุ่มให้มีลักษณะคล้ายคลึงกันในเรื่องอายุ จำนวนโรคร่วม จำนวนกลุ่มยาที่ใช้รักษาโรค เปรียบเทียบข้อมูลพื้นฐานด้วยสถิติ Chi-square test และ Fisher’s Exact Test กลุ่มตัวอย่างทั้งสองกลุ่มมีคุณลักษณะพื้นฐานที่ไม่แตกต่างกันอย่างมีนัยสำคัญทางสถิติในทุกตัวแปร (p > .05) กลุ่มควบคุมจะได้รับการพยาบาลปกติ ในขณะที่กลุ่มทดลองได้รับโปรแกรมเสริมสร้างความรอบรู้ด้านสุขภาพผ่านไลน์แอปพลิเคชัน เครื่องมือที่ใช้ในการวิจัย ได้แก่ แบบสอบถามพฤติกรรมการจัดการตนเองด้านการบริโภคอาหารของผู้ป่วยที่มีภาวะกล้ามเนื้อหัวใจขาดเลือดเฉียบพลันที่มีโรคร่วม และแบบสอบถามประเมินความรอบรู้ด้านสุขภาพเกี่ยวกับพฤติกรรมการจัดการตนเองด้านการบริโภคอาหาร ทดสอบความตรงเชิงเนื้อหาโดยผู้ทรงคุณวุฒิ 5 คน ได้ค่าดัชนีความตรงตามเนื้อหาเท่ากับ 0.92 และ 1.00 และค่าความเที่ยงเท่ากับ 0.91 และ 0.73 วิเคราะห์ข้อมูลด้วยสถิติเชิงพรรณนา และสถิตทดสอบค่าที ผลการวิจัยสรุปได้ดังนี้ 1. คะแนนเฉลี่ยพฤติกรรมการจัดการตนเองด้านการบริโภคอาหารในผู้ป่วยภาวะกล้ามเนื้อหัวใจขาดเลือดเฉียบพลันที่มีโรคร่วม กลุ่มทดลองหลังได้รับโปรแกรมเสริมสร้างความรอบรู้ด้านสุขภาพผ่านไลน์แอปพลิเคชันสูงกว่าก่อนได้รับโปรแกรม ฯ อย่างมีนัยสำคัญทางสถิติที่ระดับ .05 2. คะแนนเฉลี่ยพฤติกรรมการจัดการตนเองด้านการบริโภคอาหารในผู้ป่วยภาวะกล้ามเนื้อหัวใจขาดเลือดเฉียบพลันที่มีโรคร่วม ที่ได้รับโปรแกรมเสริมสร้างความรอบรู้ด้านสุขภาพผ่านไลน์แอปพลิเคชันสูงกว่ากลุ่มที่ได้รับการพยาบาลตามปกติอย่างมีนัยสำคัญทางสถิติที่ระดับ .05
Umn Morris Telephone Extensions 2025-2026, University Of Minnesota - Morris
Umn Morris Telephone Extensions 2025-2026, University Of Minnesota - Morris
UMN Morris Directories
No abstract provided.
Attention Deficit Hyperactivity Disorder And Metacognitive Awareness Of Learning, Kara R. Muscha
Attention Deficit Hyperactivity Disorder And Metacognitive Awareness Of Learning, Kara R. Muscha
Theses
The present study examined knowledge updating abilities in individuals with and without ADHD when forced to metacognitively evaluate the effectiveness of different study strategies. Participants with and without ADHD were randomly assigned to either a spontaneous or a forced knowledge updating condition, with those in the latter condition being asked to keep track of encoding strategy-recall outcome results, but no additional instructions for those in the spontaneous condition. I expected that healthy control participants would show greater knowledge updating abilities than those with ADHD, the participants in the forced knowledge updating condition would show greater knowledge updating abilities than participants …
Modifying The L-Tryptophan Affinity Of The Ribosomal Arrest Peptide Tnac, Alexis Orlando Delgado Castillo
Modifying The L-Tryptophan Affinity Of The Ribosomal Arrest Peptide Tnac, Alexis Orlando Delgado Castillo
Theses
Since creating biosensors from zero has proven a more challenging enterprise than expected, resorting into naturally occurring regulatory systems already characterized represents a more accurate, rapid, and attractive option. Various previous strategies have sought to exploit and modify regulatory elements that sense for different molecules, including monosaccharides (Tang et al., 2008), secondary metabolites (Flachbart et al., 2021), and other amino acids (Della Corte et al., 2020). This study aims to leverage current scientific knowledge and advances concerning the structure and function of the ribosomal arrest peptide TnaC. With this research I integrated the TnaC ribosome-arresting peptide into a new biosensor …
Aviation Weather Forecasting Utilizing An Artificial Neural Network, Joshua Mote
Aviation Weather Forecasting Utilizing An Artificial Neural Network, Joshua Mote
Theses
Weather forecasting is critical to minimize risk and maximize efficiency for flying operations and is challenging due to the uncertainty involved in atmospheric changes. Operational area weather is becoming more critical with the growing reliance on air domain for transportation. This study investigates whether the forecasting accuracy using a Hybrid Long-Short Term Memory (LSTM) Artificial Neural Network (ANN) outperforms the San Antonio International Airport (KSAT) Terminal Aerodrome Forecast (TAF) by integrating diverse data sources – regional Meteorological Aerodrome Report (METAR), TAF, Avian Advisory System (AHAS) Data and geomagnetic activity K Index Data. When tested on one year of historical data, …
Surveying Subterranean Biodiversity Of The Tongass National Forest Using Traditional Survey Approaches And Environmental Dna (Edna) Metabarcoding, Jared P. Higgs
Theses
The Tongass National Forest (TNF) is a large temperate rainforest in southeastern Alaska, much of which is underlain by karst. Timber harvest, among other threats, can have detrimental effects on karst habitats; however, the subterranean fauna of this region is understudied and lacks a baseline for monitoring. I spent three field seasons conducting biological assessments of caves in the TNF using two approaches: traditional specimen-based sampling and eDNA metabarcoding. To improve the reference sequence database, I generated 213 novel sequences from invertebrate specimens collected from 35 caves. I also collected 125 water samples from 39 sites for environmental DNA (eDNA) …
Ultrasound-Guided Percutaneous Needle Barbotage And Ultrasonic Tenotomy For Rotator Cuff Calcific Tendinopathy, Toru Omodani
Ultrasound-Guided Percutaneous Needle Barbotage And Ultrasonic Tenotomy For Rotator Cuff Calcific Tendinopathy, Toru Omodani
Rehabilitation Practice and Science
Rotator cuff calcific tendinopathy (RCCT) is a common source of shoulder pain caused by calcium deposits within the rotator cuff tendons. Ultrasound-guided interventions have emerged as effective, minimally invasive alternatives to surgery for symptomatic cases unresponsive to conservative treatments. This review summarizes two primary techniques: percutaneous needle barbotage and percutaneous ultrasonic tenotomy. In needle barbotage, one or two needles are inserted under ultrasound guidance to inject and aspirate saline, thereby fragmenting and removing the calcific deposit. This method yields rapid pain relief and improved shoulder function, with follow-up imaging often demonstrating near-complete deposit resolution. For particularly hard or recalcitrant deposits, …
The Need To Explore The Potential Of Marine Cdr With A One-Earth Strategy: A Guide For Policy-Makers, Philip W. Boyd, Jean-Pierre Gattuso, Minhan Dai, Louis Legendre, Terre Satterfield, Romany M. Webb
The Need To Explore The Potential Of Marine Cdr With A One-Earth Strategy: A Guide For Policy-Makers, Philip W. Boyd, Jean-Pierre Gattuso, Minhan Dai, Louis Legendre, Terre Satterfield, Romany M. Webb
Sabin Center for Climate Change Law
Rapid, deep and sustained reductions in carbon dioxide (CO₂) emissions are essential to achieve the goals of the Paris Climate Agreement of keeping the long-term global average surface temperature increase well below 2°C above pre-industrial levels and pursue efforts to limit it to 1.5°C . In addition, the 2021 IPCC Report explains that carbon dioxide removal (CDR) will be needed to offset residual CO₂ emissions from activities and sectors that are difficult to decarbonize by 2050. The objective of CDR is removal of atmospheric CO2 from residual emissions and its durable storage in reservoirs, which is an additional critical element …
Investigating The Plasticity And Role Of Peripherally Derived Cd4 T Cells In The Brain At Homeostasis, Tomomi Marie Yoshida
Investigating The Plasticity And Role Of Peripherally Derived Cd4 T Cells In The Brain At Homeostasis, Tomomi Marie Yoshida
Yale Graduate School of Arts and Sciences Dissertations
Specialized immune cells residing in tissues orchestrate diverse biological functions through communication with parenchymal cells. The contribution of the innate immune compartment in the meninges and central nervous system (CNS) is well-characterized, however, whether T cells as part of the adaptive immune system reside in the brain and are involved in homeostasis is poorly understood. Here, we identify that the subfornical organ (SFO) region of the brain is a nucleus for parenchymal T cells in the steady-state brain in both mice and humans. Using unbiased transcriptomics, we found that these extravascular T cells in the mouse brain are distinct from …
Host Defense Inside & Outside Of The Immune System: Modeling Antimicrobial Immunity By Gbps, Zhongyu Yuan
Host Defense Inside & Outside Of The Immune System: Modeling Antimicrobial Immunity By Gbps, Zhongyu Yuan
Yale Graduate School of Arts and Sciences Dissertations
Traditional views of host defense often focus on antibody-mediated neutralization, cytotoxic T-cell plus NK-cell-mediated killing, and phagocytic activities by cell populations originating in the bone marrow as part of the classical immune system. Additional effector activities, however, also operate in non-immune cells which compose the stroma or parenchyma of host tissues. These latter cell populations often mobilize antimicrobial activities in response to cytokines such as type II IFN (IFN-gamma; IFN-) against a wide variety of intracellular pathogens.
Among the most prominent IFN--stimulated genes are a family of immune dynamin-like GTPases termed the Guanylate Binding Proteins (GBPs). GBPs are widely expressed …
The University Of Texas Permian Basin 2025-2026 Undergraduate Catalog 2025-2026, The University Of Texas Permian Basin
The University Of Texas Permian Basin 2025-2026 Undergraduate Catalog 2025-2026, The University Of Texas Permian Basin
Course Catalogs
No abstract provided.
The University Of Texas Permian Basin 2025-2026 Graduate Studies Catalog, The University Of Texas Permian Basin
The University Of Texas Permian Basin 2025-2026 Graduate Studies Catalog, The University Of Texas Permian Basin
Course Catalogs
No abstract provided.
Baseline Disease Characteristics By Surgery History Among Patients With Chronic Rhinosinusitis With Nasal Polyps (Crswnp) In The Global Aroma Registry, Shigeharu Fujieda, Jayant M. Pinto, David W. Jang, Joseph K. Han, James Mims, Eugenio De Corso, Martin Wagenmann, Changming Xia, Thomas Plucinak, Mark Corbett, Scott Nash, Amr Radwan
Baseline Disease Characteristics By Surgery History Among Patients With Chronic Rhinosinusitis With Nasal Polyps (Crswnp) In The Global Aroma Registry, Shigeharu Fujieda, Jayant M. Pinto, David W. Jang, Joseph K. Han, James Mims, Eugenio De Corso, Martin Wagenmann, Changming Xia, Thomas Plucinak, Mark Corbett, Scott Nash, Amr Radwan
Department of Otolaryngology (ENT) Faculty Publications
Purpose
The global Assessing long-teRm Outcomes in dupiluMAb (AROMA) registry study aims to characterize the long-term, real-world use of dupilumab in patients with chronic rhinosinusitis with nasal polyps (CRSwNP). This paper reports interim analysis of the baseline characteristics for the first 303 patients enrolled in AROMA.
Methods and materials
AROMA is currently ongoing in adult patients with CRSwNP who initiated dupilumab for up to 36 months. This interim analysis describes baseline demographics; systemic/oral corticosteroid (SCS/OCS) and antibiotic use; disease burden; healthcare resource utilization; and medical history. All outcomes are summarized descriptively.
Results
As of February 2023, AROMA had enrolled 303 …
Size Of Pediatric Tracheostomy Tube And Predictors Of Postoperative Complications, Soukaina Eljamri, Jordyn Lucas, Amber Shaffer, Basil Hashimi, Marina Rushchak, Reema Padia
Size Of Pediatric Tracheostomy Tube And Predictors Of Postoperative Complications, Soukaina Eljamri, Jordyn Lucas, Amber Shaffer, Basil Hashimi, Marina Rushchak, Reema Padia
Department of Otolaryngology (ENT) Faculty Publications
Objective
(1) To investigate weight as an alternative guide for trach tube choice. (2) Evaluate complications 3-month posttracheostomy and associations with patient and trach tube factors.
Study design
Retrospective cohort study.
Setting
Single academic medical center.
Methods
Patients < 2 years old who underwent tracheostomy placement from 2017 to 2022 were identified. Associations between trach characteristics, trach size/length, chest x-ray (CXR) and intraoperative endoscopy measurements, and complications within 3 months posttracheostomy placement were evaluated.
Results
In total, 68 patients were included in the study, with a median age of 4 months (range: 1 day to 1.74 years) and weight of 4.1 kg (range: 1.8-11.6 kg) at the time of the procedure. The length of the trachea measured on CXR was more closely associated with weight (ρ = 0.403, P = .0007) than with age (ρ = …
A Comparison Of Allergen Sensitization Profiles In Patients With Chronic Rhinosinusitis With And Without Nasal Polyposis, Lauren Trzcinski, Suhas Bharadwaj, Randall A. Bloch, Joseph K. Han, Kent K. Lam
A Comparison Of Allergen Sensitization Profiles In Patients With Chronic Rhinosinusitis With And Without Nasal Polyposis, Lauren Trzcinski, Suhas Bharadwaj, Randall A. Bloch, Joseph K. Han, Kent K. Lam
Department of Otolaryngology (ENT) Faculty Publications
Chronic rhinosinusitis (CRS) and allergic rhinitis (AR) are common comorbid sinonasal conditions. CRS is classically divided into two distinct phenotypes: CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP). The purpose of this retrospective observational study is to determine whether aeroallergen sensitization profiles in patients with comorbid CRS and AR can distinguish between CRSwNP and CRSsNP. A total of 241 patients diagnosed with comorbid CRS and AR who underwent skin prick testing or in vitro allergy testing in a single tertiary rhinology practice were included for evaluation. The rates of allergen-specific sensitizations in CRSwNP patients were compared with …
Liposomes As A Platform For Cd40 Ligand Presentation For The Purpose Of Feeder-Free B Cell Activation, Sydney Bone
Liposomes As A Platform For Cd40 Ligand Presentation For The Purpose Of Feeder-Free B Cell Activation, Sydney Bone
Theses
Improvement of in-vitro culture of immune cells is critical for expanding our understanding of the immune system and advancing the treatment of diseases, whether pathogenic, cancerous, or autoimmune, via cellular immunotherapies. This study aims to develop a feeder-free B cell culture system using biomaterials-based presentation of a critical signaling molecule, namely CD40 ligand (CD40L). Traditional B cell culture methods rely on allogenic feeder cells to present CD40L, but a culture of only autologous cells is preferable for cellular immunotherapies. Previous work of our lab established an effective feeder-free B cell culture system using magnetic microbeads as a synthetic platform for …
Factors Affecting Freshwater Fish Communities In Two North Alabama Counties, Joshua Fitts
Factors Affecting Freshwater Fish Communities In Two North Alabama Counties, Joshua Fitts
Theses
This study examined how physical habitat characteristics influence freshwater fish diversity in streams of Madison and Limestone Counties, Alabama. Ten 150-meter stream reaches were sampled using backpack electrofishing and seining, with habitat variables measured at fixed transects. Principal component analysis identified four main habitat gradients representing flow and substrate, channel size, gravel dominance, and canopy–bedrock conditions. Although overall species richness and Shannon diversity were not significantly related to these gradients, species-specific correlations revealed clear ecological preferences. Regression models showed that root wads, herbaceous vegetation, and riprap modestly increased richness, emphasizing the role of structural diversity. These findings highlight the importance …
Correlates Of Body Image And Physical Self-Concept, Rashuna Middleton
Correlates Of Body Image And Physical Self-Concept, Rashuna Middleton
College of Graduate Studies: Theses & Dissertations
The growing overlap between social media and celebrity culture has played a significant role in shaping individuals' perceptions of body image and self-worth. This study explored the relationship between celebrity worship, problematic social media use, narcissism, physical self-concept, and body image among undergraduate psychology students. This study utilized the Celebrity Attitude Scale (CAS), the Narcissistic Personality Inventory (NPI), the Maladaptive Covert Narcissism Scale (MCNS), the Bergen Social Media Addiction Scale (BSMAS), the Body Influence Assessment Inventory (BIAI), the Self-Objectification Questionnaire (SOQ), and the Rosenberg Self-Esteem Scale (RSE). Findings indicated that vulnerable narcissism positively correlated with body image, whereas grandiose narcissism …
Success Is A Journey, Not A Destination: The Student Library Assistants Of Georgia (Slags) At G. W. Carver School In Richmond Hill, Georgia, 1960-1968, Christopher C. Elkins
Success Is A Journey, Not A Destination: The Student Library Assistants Of Georgia (Slags) At G. W. Carver School In Richmond Hill, Georgia, 1960-1968, Christopher C. Elkins
College of Graduate Studies: Theses & Dissertations
This dissertation examines two chapters of Black education in Georgia that have been largely ignored in the study of curriculum and educational history, namely the George Washington Carver School located in Richmond Hill, Georgia and the Student Library Assistants of Georgia (SLAGS) that existed statewide in many Black schools. G.W. Carver School, built in 1939 and funded by automaker Henry Ford, is mentioned briefly in multiple works that either relate to Ford or cover the general history of Richmond Hill. Utilizing oral history and archival documents, this study emphasizes the significant contribution the SLAGS program made to students at G. …
Unmasked, Unbroken, And Transgressional: A Womanist Approach To Black Female Educators' Experiences With Intersectionality And Their Quest To Teach For Educational Liberation, Ty-Ria S. Jenkins
College of Graduate Studies: Theses & Dissertations
This qualitative study examines the experiences of six Black female educators committed to educational liberation, using Baszile’s (2006) Black Self and Beauboeuf-Lafontant’s (2008) politicized mothering as frameworks. Grounded in Black feminist thought (Hill Collins, 2000) and womanist pedagogy (Walker,1983), it explores how these educators navigate race, gender, and systemic barriers in education. Through qualitative interviews and sista circles (Johnson, 2015), participants shared their journeys of self-realization, political clarity, and transgressional teaching practices.
Findings reveal that Black female educators embody three layers of the Black Self—emergence, absence “invisibility” and self-awareness—while also engaging in politicized mothering through maternal care, political clarity, and …
Impact Of Y-Mixer Geometry And Flow Rate Modulation On Chemical Gradient Generators In Microfluidic Devices, Elizabeth Thurston Hutton
Impact Of Y-Mixer Geometry And Flow Rate Modulation On Chemical Gradient Generators In Microfluidic Devices, Elizabeth Thurston Hutton
College of Graduate Studies: Theses & Dissertations
Various microfluidic structures are devised to generate tunable, stable spatiotemporal chemical gradients for single-cell studies. This work addresses the role of Y-mixer junctions in generating nonlinear gradients by increasing the width of one arm (bias), which is suspected to cause premature diffusion within the mixer. This study introduced a cinching feature to narrow the wider arm locally and redefine the junctions of these biased Y-mixers using four novel geometries defined by a 5-micrometer drawing rule. Furthermore, three flow rate factors allowed us to explore the impact on the generated gradient landscapes. The results showed that the four novel designs similarly …
Synthesis Of Tu100 Analogs And Biological Assays, Feyisope Tonye Oladapo
Synthesis Of Tu100 Analogs And Biological Assays, Feyisope Tonye Oladapo
College of Graduate Studies: Theses & Dissertations
TU100 (14-methyl-5H-5,12-epiminobenzo[4,5]cyclohepta[1,2-b]naphthalene-6,11,13(12H)-trione) exhibits exceptional chemotherapeutic properties. It operates via a distinct mechanism that triggers cell death to create cytotoxic effects while concurrently inhibiting topoisomerase I and II. Its efficacy rivals that of well-known chemotherapeutic drugs like Daunorubicin. The distinctive characteristics of TU100 have led to initiatives aimed at creating structurally similar compounds to discover even more effective bioactive alternatives.
The analog synthesis incorporated quinoxaline or its derivatives (diphenyl quinoxaline, dipyridinyl quinoxaline, and dibenzophenazine-10,13-dione) that have been shown to have promising chemotherapeutic effects. Synthesizing the hetero naphthoquinones required a multi-step synthetic process, so quinoxaline/ derivatives intermediates are first prepared, then the …
Quantifying Inositol Phosphate Dephosphorylation To Understand The Role Of Recalcitrant Organic Phosphorus Forms On Harmful Algal Blooms In Freshwater Systems, Iffat Tasnim
College of Graduate Studies: Theses & Dissertations
Organophosphorus such as phytic acid, a surrogate species of inositol phosphate (IP), may serve as a source for orthophosphate (OP) in freshwater. In absence of OP, competent aquatic microorganisms upregulate the production of specialized enzymes to obtain growth-sustaining OP from organic phosphorus (org-P) forms. The contribution of recalcitrant org-P to the OP pool has been overlooked due to the lack of capable tools to measure OP production from org-P accurately. The objective of this study was to quantify OP production from phytic acid (a surrogate form of recalcitrant org-P) to assess the contribution of recalcitrant org-P forms to the total …