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Quantifying Inositol Phosphate Dephosphorylation To Understand The Role Of Recalcitrant Organic Phosphorus Forms On Harmful Algal Blooms In Freshwater Systems, Iffat Tasnim Jan 2025

Quantifying Inositol Phosphate Dephosphorylation To Understand The Role Of Recalcitrant Organic Phosphorus Forms On Harmful Algal Blooms In Freshwater Systems, Iffat Tasnim

College of Graduate Studies: Theses & Dissertations

Organophosphorus such as phytic acid, a surrogate species of inositol phosphate (IP), may serve as a source for orthophosphate (OP) in freshwater. In absence of OP, competent aquatic microorganisms upregulate the production of specialized enzymes to obtain growth-sustaining OP from organic phosphorus (org-P) forms. The contribution of recalcitrant org-P to the OP pool has been overlooked due to the lack of capable tools to measure OP production from org-P accurately. The objective of this study was to quantify OP production from phytic acid (a surrogate form of recalcitrant org-P) to assess the contribution of recalcitrant org-P forms to the total …

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Geophysics, And Capturing Ethnographic Interviews Of A Tidal Plantation Burial Ground, Kristin M. Meeuwen (Dew) Jan 2025

Geophysics, And Capturing Ethnographic Interviews Of A Tidal Plantation Burial Ground, Kristin M. Meeuwen (Dew)

College of Graduate Studies: Theses & Dissertations

Plantation development in Chatham County has a rich but incomplete history. Silk Hope, an Ogeechee District tidal plantation, is located seven miles from the city of Savannah on the Northern banks of the Little Ogeechee River. This project focuses on identifying the site boundaries of portions of Silk Hope Plantation and its historical background. Specifically, the project focused on delineating the boundaries of the associated cemetery and/or burial grounds, while estimating the number of individuals interred there using ground-penetrating radar (GPR). Finally, collaborative work with community members, including stakeholder and descendant interviews, will provide ethnographic insights into the site's history …

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Synthesis And Assessment Of Biobased Acrylated Epoxidized Soybean Oil Resins For Stereolithography 3d Printing Of Microfluidic Devices, Natalie S. Romero Figueroa Jan 2025

Synthesis And Assessment Of Biobased Acrylated Epoxidized Soybean Oil Resins For Stereolithography 3d Printing Of Microfluidic Devices, Natalie S. Romero Figueroa

College of Graduate Studies: Theses & Dissertations

This research focuses on the development and characterization of a biobased photocurable resin synthesized from soybean oil for use in stereolithography (SLA) 3D printing of microfluidic devices. The study explores a sustainable alternative to petroleum-based resins by performing an acrylation reaction on epoxidized soybean oil (ESO) to produce acrylated epoxidized soybean oil (AESO), which was then formulated into a photocurable resin with the addition of a photo initiator. The fabrication process involved designing microfluidic molds in SolidWorks and printing them using an Elegoo Mars 4 SLA printer under various exposure and layer thickness parameters. The printed samples consisted of microchannels …

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Eros And The Sublime: Tools For Reaching Toward An Altered Ecological Consciousness, Aineka Carlson Jan 2025

Eros And The Sublime: Tools For Reaching Toward An Altered Ecological Consciousness, Aineka Carlson

Graduate Student Theses, Dissertations, & Professional Papers

This thesis explores connections between the Kantian sublime and Anne Carson’s ideas regarding “eros.” Since Kant’s Critique of Judgement was published in 1790, the Kantian sublime has grown in popularity and been utilized by theorists and creative writers alike. While the Kantian sublime is often associated with nature in popular culture, there are certain egocentric and phallocentric elements of this mode of thinking that might inhibit a biocentric mindset. Through a character study of Oryx from Margaret Atwood’s novel Oryx and Crake, this thesis draws relations between the subjugation of women, nature, and the ways in which the popularized …

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Serious Bacterial Infections And Hepatitis C Virus Among People Who Inject Drugs, Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean Dejace, Judith Feinberg, April M. Young, Wei Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann Jan 2025

Serious Bacterial Infections And Hepatitis C Virus Among People Who Inject Drugs, Thomas J. Stopka, Robin M. Nance, L. Sarah Mixson, Hunter Spencer, Judith I. Tsui, Judith M. Leahy, Mai T. Pho, Jean Dejace, Judith Feinberg, April M. Young, Wei Teng Yang, Amelia Baltes, Eric Romo, Randall T. Brown, Kerry Nolte, William C. Miller, William A. Zule, Wiley D. Jenkins, Joseph A. Delaney, Peter D. Friedmann

Epidemiology and Environmental Health Faculty Publications

Limited research has examined the possible synergistic interrelationships between serious bacterial infections (SBIs) of the heart (i.e., endocarditis), bone, spine, brain, or joints (e.g., osteomylelitis) and hepatitis C virus (HCV) infections. We examined whether syndemic interactions existed between SBI, HCV, and substance-use-related factors in rural communities, hypothesizing that injection-mediated risks elevated the likelihood for both SBIs and HCV infections, which could be exacerbated by synergistic biological–biological or biological and social interactions. We calculated the prevalence ratios (PRs) of past-year SBI associated with each risk factor in separate models. Effect modification among significant risk factors was assessed using multiplicative interaction. Among …

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Viral Transcript And Tumor Immune Microenvironment-Based Transcriptomic Profiling Of Hpv-Associated Head And Neck Squamous Cell Carcinoma Identifies Subtypes Associated With Prognosis, Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden Jan 2025

Viral Transcript And Tumor Immune Microenvironment-Based Transcriptomic Profiling Of Hpv-Associated Head And Neck Squamous Cell Carcinoma Identifies Subtypes Associated With Prognosis, Anastasiia Nikitina, Daria Kiriy, Andrey Tyshevich, Dmitry Tychinin, Zoya Antysheva, Anastasya Sobol, Vladimir Kushnarev, Nara Shin, Jessica H. Brown, James Lewis, Krystle A. Lang Kuhs, Robert Ferris, Lori Wirth, Nikita Kotlov, Daniel L. Faden

Epidemiology and Environmental Health Faculty Publications

Human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HPV-positive HNSCC) has distinct biological characteristics from HPV-negative HNSCC. Using an AI-based analytical platform on meta cohorts, we profiled expression patterns of viral transcripts and HPV viral genome integration, and classified the tumor microenvironment (TME). Unsupervised clustering analysis revealed five distinct and novel TME subtypes across patients (immune-enriched, highly immune and B-cell enriched, fibrotic, immune-desert, and immune-enriched luminal). These TME subtypes were highly correlated with patient prognosis. In order to understand specific factors associated with prognosis, we used the unsupervised clustering of an HPV-positive HNSCC cohort from The Cancer Genome Atlas …

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Fairehr, Karen S. Galea, Finlay Brooker, Shahzad Rashid, Michael Bader, Yu Ait Bamai, Jos Bessems, Embialle Mengistie Beyene, Alison Connolly, Carla Costa, Pravina Deligannu, Radu Corneliu Duca, Kaoutar Chbihi, Kasahun Eba, Manosij Ghosh, Melissa Gonzales, Stuart Harrad, Erin N. Haynes, Nancy B. Hopf, Po Chin Huang, Kate Jones, Konstantinos M. Kasiotis, Ming Kei Chung, Jihyon Kil, Holger Koch, Jung Hwan Kwon, Elizabeth Ziying Lin, Henriqueta Louro, Kyriaki Machera Jan 2025

Fairehr, Karen S. Galea, Finlay Brooker, Shahzad Rashid, Michael Bader, Yu Ait Bamai, Jos Bessems, Embialle Mengistie Beyene, Alison Connolly, Carla Costa, Pravina Deligannu, Radu Corneliu Duca, Kaoutar Chbihi, Kasahun Eba, Manosij Ghosh, Melissa Gonzales, Stuart Harrad, Erin N. Haynes, Nancy B. Hopf, Po Chin Huang, Kate Jones, Konstantinos M. Kasiotis, Ming Kei Chung, Jihyon Kil, Holger Koch, Jung Hwan Kwon, Elizabeth Ziying Lin, Henriqueta Louro, Kyriaki Machera

Epidemiology and Environmental Health Faculty Publications

The FAIREHR (Findable, Accessible, Interoperable, Reusable Environmental and Health Registry) platform is a state-of-the-art online registry for prospective harmonization of human biomonitoring (HBM). It was developed by the HBM working group of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe) and is supported by the HBM Global Network. FAIREHR is designed to harmonize HBM metadata and support the implementation of the FAIR (Findable, Accessible, Interoperable and Reusable) Guiding Principles throughout HBM studies or programs. The registry enables preregistration of HBM by capturing key metadata on study design, metadata management, and planned methods before participant recruitment. …

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Monte Carlo Gradient Boosted Trees For Cancer Staging: A Machine Learning Approach, Audrey Eley, Thu Thu Hlaing, Daniel Breininger, Zarindokht Helforoush, Nezamoddin N. Kachouie Jan 2025

Monte Carlo Gradient Boosted Trees For Cancer Staging: A Machine Learning Approach, Audrey Eley, Thu Thu Hlaing, Daniel Breininger, Zarindokht Helforoush, Nezamoddin N. Kachouie

Mathematics and System Engineering Faculty Publications

Machine learning algorithms are commonly employed for classification and interpretation of high-dimensional data. The classification task is often broken down into two separate procedures, and different methods are applied to achieve accurate results and produce interpretable outcomes. First, an effective subset of high-dimensional features must be extracted and then the selected subset will be used to train a classifier. Gradient Boosted Trees (GBT) is an ensemble model and, particularly due to their robustness, ability to model complex nonlinear interactions, and feature interpretability, they are well suited for complex applications. XGBoost (eXtreme Gradient Boosting) is a high-performance implementation of GBT that …

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Education About, In, And For Wetlands: Practices, Premises, Possibilities, And Challenges, Tom Marcinkowski Jan 2025

Education About, In, And For Wetlands: Practices, Premises, Possibilities, And Challenges, Tom Marcinkowski

Mathematics and System Engineering Faculty Publications

The purpose of this paper is to review areas of educational theory, research, and practice relevant to wetlands education, notably education about, in, and for wetlands. Five key areas are reviewed: (a) from the Report of the Intergovernmental Conference on Environmental Education, goals and objectives for wetlands education; (b) from the literature, major curricular and instructional approaches in and elements of wetlands education; (c) from the literature, broad instructional strategies available to and commonly used in wetlands education; (d) from websites of federal agencies in the U.S., education, outreach, and training programs that focus on education about, in, and for …

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Examining The Effects Of Songbird Nest Boxes And Habitat On Avian And Arthropod Communities In A Vineyard Ecosystem, Eleanor Macdonald Jan 2025

Examining The Effects Of Songbird Nest Boxes And Habitat On Avian And Arthropod Communities In A Vineyard Ecosystem, Eleanor Macdonald

Cal Poly Humboldt theses and projects

Agricultural expansion threatens biodiversity, but integrating insectivorous birds into vineyard ecosystems may support both conservation and ecosystem services. We tested how nest boxes and habitat composition influence avian and arthropod communities in Napa Valley vineyards using a before-after, control-impact experiment across 20 sites. During the 2023-2024 breeding seasons we conducted avian point counts, sampled key pest and beneficial arthropods, and collected fecal samples from adult and nestling tree swallows (Tachycineta bicolor) and western bluebirds (Sialia mexicana) to detect vineyard pest DNA. Nest boxes significantly increased swallow and bluebird abundance within one year; swallow responses were strongest …

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Environmental And Spatial Drivers Of Quillback Rockfish (Sebastes Maliger) Growth In The Northeast Pacific Ocean From California To Alaska, Claire E. Stuart Jan 2025

Environmental And Spatial Drivers Of Quillback Rockfish (Sebastes Maliger) Growth In The Northeast Pacific Ocean From California To Alaska, Claire E. Stuart

Cal Poly Humboldt theses and projects

Quillback rockfish (Sebastes maliger) are a nearshore fishery species found across the Northeast Pacific Ocean, but recent stock assessments have identified a research gap for biological growth parameters, particularly for the southern end of their range. Age-length data compiled from California to Alaska (n=34,396) was used to generate extended von Bertalanffy models with spatial, biological, and environmental covariates, specifically region, sex, depth, and an upwelling index. The objectives of this study were to explore how 1) spatial and 2) environmental covariates affect model parameters L∞, k, and t0. Four total models were developed: …

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Reproductive Health Education In Ghana: Perspectives Of School Health Education Programme (Shep) Coordinators, Population Council, Msi Reproductive Choices, Ghana Education Service, Ghana Health Service Jan 2025

Reproductive Health Education In Ghana: Perspectives Of School Health Education Programme (Shep) Coordinators, Population Council, Msi Reproductive Choices, Ghana Education Service, Ghana Health Service

Sexual and Reproductive Health, Rights, and Choices

Schools in Ghana have integrated reproductive health education (RHE) topics into their curricula and School Health Education Programme (SHEP) Coordinators recognize the importance of RHE. However, for RHE to reach its full potential, it needs to be established as a stand-alone subject. This study highlights the challenges and opportunities in delivering in-school RHE, underscoring the interplay between policy frameworks, implementation strategies, and locally accepted approaches.

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Defining An Irrelevant Plasma Concentration For Trichlormethiazide In Racing Horses – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin Jan 2025

Defining An Irrelevant Plasma Concentration For Trichlormethiazide In Racing Horses – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

This communication reviews the matter of the clinical, pharmacological, and regulatory significance of a 4.95 nanogram/ml identification of trichlormethiazide in urine from a horse six days after administration of a compounded trichlormethiazide/ dexamethasone preparation. This combination of dexamethasone and trichlormethiazide has historically been widely used in bovine and equine medicine to reduce local inflammation and edema. The horse was administered an oral formulation of trichlormethiazide 400 mg /dexamethasone 10 mg per packet under veterinary supervision on days 7 and 6 before the race in question. Following the race, the post-race urine sample from the horse tested “positive” for trichlormethiazide at …

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Trace Level Identifications Of N-Ethylnicotinamide In Racing Horses Associated With A Vitamin B3 Supplement: Case Reports And Analysis, Clara Fenger, Kimberly Brewer, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin Jan 2025

Trace Level Identifications Of N-Ethylnicotinamide In Racing Horses Associated With A Vitamin B3 Supplement: Case Reports And Analysis, Clara Fenger, Kimberly Brewer, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Nikethamide, N,N-diethyl-3-pyridinecarboxamide (Coramine®) is a central nervous system stimulant at one time used therapeutically in human medicine but no longer marketed in the US. Nikethamide is classified a Drug Class 1, Penalty Class A substance by the Association of Racing Commissioners International (ARCI) and as a Horseracing Integrity and Safety Authority (HISA) SO or banned Stimulant that lacks FDA approval. Identifications of Nikethamide or its metabolite N-Ethylnicotinamide in racing samples can result in significant penalties in horse racing. Nikethamide is rapidly metabolized to N-Ethylnicotinamide, which remains detectable in plasma and urine leading to its use as a regulatory “marker” of …

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What Shapes Environmental Identity: Insights From Highly Environmentally Literate Students, Marušić-Jablanović Milica, Zorica Stanišić, Jelena Stanišić, Dragana Gundogan, Tom Marcinkowski Jan 2025

What Shapes Environmental Identity: Insights From Highly Environmentally Literate Students, Marušić-Jablanović Milica, Zorica Stanišić, Jelena Stanišić, Dragana Gundogan, Tom Marcinkowski

Mathematics and System Engineering Faculty Publications

The paper aimed to describe features of the environmental identity of primary school students (age 13-14) in Serbia, as well as the experiences they find most influential in shaping their environmental identity. Specifically, students from the two best-performing classes (N=34), based on their scores on environmental literacy assessment responded to an open-ended questionnaire regarding their relationship with nature and the most important experiences shaping this relationship, in both private and school contexts. The students offered evidence of features of their environmental identity in terms of: environmental affect-sensitivity, environmental concern, moral reasoning, as well as pro-environmental behavior as its correlate. Both …

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Combination Of Hsp90 Inhibitors And Hsp70 Inducers Prevent Hydrochloric Acid-Induced Pulmonary Fibrosis In Rabbits, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Dan E. Austin Jr., Len E. Murray, John D. Catravas Jan 2025

Combination Of Hsp90 Inhibitors And Hsp70 Inducers Prevent Hydrochloric Acid-Induced Pulmonary Fibrosis In Rabbits, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Dan E. Austin Jr., Len E. Murray, John D. Catravas

Bioelectrics Publications

Combined therapies with Heat Shock Protein 90 (HSP90) inhibitors and Heat Shock Protein 70 (HSP70) inducers are gaining significant interest in cancer and cardiovascular research. Here, we tested the hypothesis that HSP90 inhibitors and HSP70 inducers, together, can block the development of pulmonary fibrosis. We exposed New Zealand White Rabbits to hydrochloric acid (HCl, 0.1 N, 1.5 mL/kg), one of the top five chemicals most commonly involved in accidental exposures and inhalation injuries worldwide, and treated animals with either the orally available HSP90 inhibitor TAS-116 (1.7 mg/kg 5x/week) or TAS-116 combined with the HSP70 inducer, geranylgeranyl acetone (GGA, 50 mg/kg, …

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Potentiation Of Gelonin Cytotoxicity By Pulsed Electric Fields, Olga N. Pakhomova, Eleni Zivla, Giedre Silkuniene, Mantas Silkunas, Andrei G. Pakhomov Jan 2025

Potentiation Of Gelonin Cytotoxicity By Pulsed Electric Fields, Olga N. Pakhomova, Eleni Zivla, Giedre Silkuniene, Mantas Silkunas, Andrei G. Pakhomov

Bioelectrics Publications

Gelonin is a ribosome-inactivating protein with extreme intracellular toxicity but poor permeation into cells. Targeted disruption of cell membranes to facilitate gelonin entry is explored for cancer and tissue ablation. We demonstrate a hundreds- to thousands-fold enhancement of gelonin cytotoxicity by pulsed electric fields in the T24, U-87, and CT26 cell lines. The effective gelonin concentration to kill 50% of cells (EC₅₀) after electroporation ranged from <1 nM to about 100 nM. For intact cells, the EC₅₀ was unattainable even at the highest gelonin concentration of 1000 nM, which reduced cell survival by only 5–15%. For isoeffective electroporation treatments using 300 ns, 9 µs, and 100 µs pulses, longer pulses were more efficient at lowering gelonin EC₅₀. Increasing the electric field strength of 8, 100 µs pulses from 0.65 to 1.25 kV/cm reduced gelonin EC₅₀ from 128 nM to 0.72 nM. Conversely, the presence of 100 nM gelonin enabled a more than 20-fold reduction in the number of pulses required for equivalent cell killing. Pulsed electric field-mediated delivery of gelonin shows promise for hyperplasia ablation at concentrations sufficiently low to minimize or avoid systemic toxicity.

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The Effect Of Liquid Conductivity On A Helium Plasma Jet And The Hydrogen Peroxide Production, Edwin A. Oshin, M. Ziaur Rahman, Chunqi Jiang Jan 2025

The Effect Of Liquid Conductivity On A Helium Plasma Jet And The Hydrogen Peroxide Production, Edwin A. Oshin, M. Ziaur Rahman, Chunqi Jiang

Bioelectrics Publications

Understanding plasma-liquid interactions and the impact of the electrical conductivity (σ) of liquid on plasma is important for plasma applications in water treatment and medicine. Ultrapure water, phosphate-buffered saline (PBS) solution, biological media, and sodium chloride (NaCl) solutions at various concentrations were used in this study to provide a broad range of conductivity values ranging from 0.055 μS cm−1 to 222 mS cm−1. A helium atmospheric pressure plasma jet (APPJ) impinging on liquid was generated in ambient air using a hollow-needle electrode that was powered by 200 ns, 7 kV pulses at a pulse repetition frequency of …

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Physical Ablative Methods And Cancer Cell Death: Implications For Immunity And Therapies, Alessandra Rossi, Claudia Muratori Jan 2025

Physical Ablative Methods And Cancer Cell Death: Implications For Immunity And Therapies, Alessandra Rossi, Claudia Muratori

Bioelectrics Publications

Surgery has traditionally been a cornerstone in cancer treatment, yet its feasibility can be limited by factors such as tumor location and patient health conditions. When surgery is not viable, thermal and pulsed electric field (PEF)-based ablation technologies offer valuable alternatives. Emerging evidence suggests that these approaches not only target tumors effectively but also stimulate antitumor immune responses. In this review, we begin by examining the distinctive features of hyperthermic treatments (radiofrequency and microwave ablation), cryoablation, and PEF-technologies. Subsequently, we discuss the mechanisms of cell death, stress responses, and release of danger signals triggered by these diverse ablation technologies. Finally, …

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Assessment Of The Genetic Population Structure And Extent Of Clonality In A Rare Serpentine Endemic, Lathyrus Biflorus T.W. Nelson & J.P. Nelson (Fabaceae), Using Ddrad Sequencing, Ashley Dickinson Jan 2025

Assessment Of The Genetic Population Structure And Extent Of Clonality In A Rare Serpentine Endemic, Lathyrus Biflorus T.W. Nelson & J.P. Nelson (Fabaceae), Using Ddrad Sequencing, Ashley Dickinson

Cal Poly Humboldt theses and projects

Lathyrus biflorus, or the two-flowered pea, is a rare herbaceous perennial restricted to a single population in Northern California. The species is considered critically imperiled but remains unprotected under state or federal endangered species acts. Despite its rarity, little is known about its life history, reproductive biology, or genetic diversity. Using genome-wide reduced representation sequencing, this study aimed to address these gaps by investigating the molecular evidence of clonality, the number and diversity of genets (unique genetic individuals which can be made up of one or many clonal units or ramets), and overall genetic health of the population. My …

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“We Are The Future Of This Community”: Exploring Belonging And Rural Healthcare Practice Intent In A High School Medical Sciences Club: A Case Study Of Rural Youth Identity, Purpose, And Place, Sydney Ann Lyons Jan 2025

“We Are The Future Of This Community”: Exploring Belonging And Rural Healthcare Practice Intent In A High School Medical Sciences Club: A Case Study Of Rural Youth Identity, Purpose, And Place, Sydney Ann Lyons

Cal Poly Humboldt theses and projects

Rural communities across the United States are facing critical healthcare workforce shortages, threatening access to quality care for underserved populations. Health career pathway programs offer a promising solution: a “grow our own” strategy to inspire local youth to pursue healthcare careers. However, little research has explored the role of belonging, identity development, and place-connection in strengthening these programs' outcomes. This case study investigates how participation in the Medical Sciences Club at Del Norte High School— located in rural Northern California— shapes students’, personal growth, career purpose, and rural healthcare practice intent. Through interviews with students, educators, and parents, I found …

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Post-Prohibition Changes In Cannabis Genetics, Caleb Y. Chen Jan 2025

Post-Prohibition Changes In Cannabis Genetics, Caleb Y. Chen

Cal Poly Humboldt theses and projects

This research examines changes in Cannabis genetics with a focus on Cannabis genetic bottlenecking. Significant knowledge gaps exist in the study of how and why Cannabis genetics have changed over time. To fill these gaps, a series of semi-structured qualitative interviews were conducted with self-identified Cannabis breeders around the world. Previous qualitative Cannabis research has centered around users, growers, and dealers with few studies looking exclusively at Cannabis breeders. Results include insights into becoming a Cannabis breeder, Cannabis ideotypes, as well as Cannabis genetic bottlenecking due to unanticipated genetic linkages combined with the emphasis on breeding for agronomic factors such …

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The Impact Of Plant-Based Diets On Erythrocyte Function, Oxidative Stress, And Vascular Inflammation In Type 2 Diabetes Mellitus, Walter G. Craig Jan 2025

The Impact Of Plant-Based Diets On Erythrocyte Function, Oxidative Stress, And Vascular Inflammation In Type 2 Diabetes Mellitus, Walter G. Craig

Cal Poly Humboldt theses and projects

Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disorder with diverse etiological contributors, characterized by insulin resistance, chronic inflammation, oxidative stress, and an increased risk of vascular complications. While much research has focused on plasma and serum markers of metabolic dysfunction, the role of erythrocytes in diabetic pathophysiology remains underexplored. This review examines the impact of dietary macronutrient composition, particularly plant-based diets, on erythrocyte function, oxidative stress, and vascular inflammation in T2DM. Red blood cells (RBCs) are not only oxygen carriers but also dynamic regulators of immune and inflammatory responses, with structural and functional alterations playing a critical role …

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Factors Influencing Elk Road Crossing Behavior, Brielle Christine Jaglowski Jan 2025

Factors Influencing Elk Road Crossing Behavior, Brielle Christine Jaglowski

Cal Poly Humboldt theses and projects

Highways fragment habitat and can impose barriers to wildlife. Installing wildlife crossing systems creates opportunities for safe animal movement, improved human safety, and reduced property damage. Research identifying key zones of connectivity can aid in providing recommendations for locations of these systems and other tools to improve highway safety. Although elk-vehicle collisions occur broadly across northwestern California, factors associated with these highway crossing zones have not been studied in this region. To address this gap in research, the objective of this study was to evaluate how environmental and structural factors influence the probability of elk (Cervus canadensis) crossing US-101 in …

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Investigating The Refugial River Mouth Hypothesis: Assessing The Effects Of Low Salinity Conditions On The Microscopic Life Stages Of Nereocystis Luetkeana, Duncan Jackson Jan 2025

Investigating The Refugial River Mouth Hypothesis: Assessing The Effects Of Low Salinity Conditions On The Microscopic Life Stages Of Nereocystis Luetkeana, Duncan Jackson

Cal Poly Humboldt theses and projects

Populations of Nereocystis luetkeana (bull kelp) have experienced localized extinction events in northern California since 2014 due to multiple stressor events, including the area’s most severe marine heatwave (MHW) to-date. Previous surveys in the region observed that bull kelp recovered and persisted at river mouths following the 2014-2015 MHW, suggesting that river mouths may serve as refugia – the refugial river mouth hypothesis. My study aimed to assess this hypothesis and the long-term stability of these refugia by studying how freshwater influences communities at these sites and bull kelp recruitment. Field surveys of salinity fluctuation and kelp and sea urchin …

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A Review Of Contact Dependent Interactions Among Encrusting Bryozoans, Sheena Emily Stephens-Norton Jan 2025

A Review Of Contact Dependent Interactions Among Encrusting Bryozoans, Sheena Emily Stephens-Norton

Cal Poly Humboldt theses and projects

This review of published literature is focused on bryozoan interactions and discusses overgrowths, “stalemates,” erect bi-laminate growths and fusions. Overgrowths, where one colony grows zooids atop another, have received the most attention in the scientific literature. Stalemates, where two colonies cease growth at the region of contact, have received relatively little research investigating the possible reasons for its occurrence. Erect, bi-laminate growth, following inter- and/or intraspecific contact between colonies, has also received little research, but could reflect mutualistic behavior of encrusting species to increase feeding and reproduction. Fusion of self-self-contacts appears common, yet non-self-fusions to form natural chimeras may also …

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Twice-Exceptionalism And The Complexity Of Supporting Students Who Are Both Gifted And Disabled, River Johnathon Taylor Jan 2025

Twice-Exceptionalism And The Complexity Of Supporting Students Who Are Both Gifted And Disabled, River Johnathon Taylor

Cal Poly Humboldt theses and projects

Drawing on ideas from disabilities studies about compulsory able-bodiedness as well as experiences of disability being fluid and context dependent, this study posits that giftedness, just like disability, is a complex multidimensional form of identity that is both context and temporally dependent. Twice-exceptionalism is defined as an identity in which an individual is gifted in at least one domain of human productivity and manifests at least one disability. Students with unique learning needs (students with disabilities, students with giftedness, and students with twice-exceptionalism) face many complex challenges within Humboldt County, California. Twenty-five educators from Humboldt County working across all grade …

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Patterns Of Tree Damage And Fuels Around Powerlines In Northern California, Zoe J. Ziegler Jan 2025

Patterns Of Tree Damage And Fuels Around Powerlines In Northern California, Zoe J. Ziegler

Cal Poly Humboldt theses and projects

Rural powerlines are critical for delivering electricity to communities far from urban areas but present a significant hazard when located in forested regions. During strong wind events, tree failure (i.e., broken branches, snapped stems, and windthrow) can bring combustible material in contact with high-voltage lines, causing electrical outages or setting fire to vegetation below the powerline. Additionally, elevated forest fuel loading can increase wildfire rate of spread and intensity, potentially increasing negative ecosystem impacts and decreasing containment capacity during powerline- ignited wildfires. The risks associated with rural electrical infrastructure, tree failure, and elevated fuel loading emphasize the need for improved …

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Physiological Conditions Of Barn Owl (Tyto Furcata) Nestlings As Indicators Of Habitat Quality Within The Wine-Growing Region Of Napa Valley, Christian Cortez Jan 2025

Physiological Conditions Of Barn Owl (Tyto Furcata) Nestlings As Indicators Of Habitat Quality Within The Wine-Growing Region Of Napa Valley, Christian Cortez

Cal Poly Humboldt theses and projects

The global environmental impacts of increasing agricultural demand a transition to sustainable farming practices, including the use of integrated pest management to decrease reliance on harmful pesticides. Vineyard managers in Napa Valley, California, have implemented this strategy by establishing nest boxes that attract barn owls (Tyto furcata) which, in turn, provide an ecosystem service by removing rodent pests. Studies in this system have found uncultivated landcover to be positively associated with distributional and demographic measures of habitat quality for barn owls, but individual measures have not been thoroughly explored. I examined three physiological conditions of barn owl nestlings …

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Place-Based Learning Practices: A Diptych Case Study Of Human And More-Than-Human Relationality At The Tribal And Western Academic Institutional Interface, Karley M. Rojas-Vienneau Jan 2025

Place-Based Learning Practices: A Diptych Case Study Of Human And More-Than-Human Relationality At The Tribal And Western Academic Institutional Interface, Karley M. Rojas-Vienneau

Cal Poly Humboldt theses and projects

The ‘Place-Based Learning Practices Project’ is a graduate project under the Native American Studies Department Rou Dalagurr Food Sovereignty Lab and Traditional Ecological Knowledges Institute (FSL). Making contributions at the intersection of Western academia and Indigenous science, it imagines and realizes content, policies, and protocols surrounding two case studies and the larger cal poly humboldt (cph) institution which respect, honor, and uplift Indigenous sovereignty and resurgence in partnership with the Blue Lake Rancheria Tribe and the greater regional tribal community. Encompassing two projects internal and external to the institution, I aim to address the construction of controlled and protective environments …

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