Digital Commons Network^™

Heavy Metals Pollution In Roadside Ecosystems, Lilian Matafu

Tanzania Journal of Engineering and Technology (TJET)

Heavy metals refer to metallic elements that are characterized by having a relatively high density and they are toxic or poisonous even at low concentration. They are environmental pollutant owing to toxicity and longevity in atmosphere and ability to accumulate in living things via bioaccumulation. They tend to enter in different system such as food chain. Analyses of water, soil sediment and the surrounding growing plants (Cynodon dactylon and Cyperus species) for selected heavy metals (Cd, Pb, Zn and Cu) were conducted on a roadside pond located at Boko MSB, Dar es Salaam. Pond water, soil sediments and plant samples …

Guarding Against Informants In Wrongful Conviction Cases. “The Trust Of The Innocent Is The Liar’S Most Useful Tool.”, Marc Consalo

The University of New Hampshire Law Review

By some estimates, tens of thousands of individuals are currently wrongfully convicted and serving time in the United States’ prison system for crimes they did not commit. Further concerning is that one of the most common reasons for these unjust outcomes rests with the use of jailhouse informants who often lie in exchange for time off their own sentences. While many other reasons exist for this epidemic, curtailing corrupt jailhouse snitches in order to reduce the harm they commit against innocent citizens is within our grasp. This Article purports to offer several solutions to reduce and in some cases eliminate …

Residual Traditional Risk In Non-Traditional Atherosclerotic Diseases, Federico Biscetti, Giorgia Polito, Maria Margherita Rando, Maria Anna Nicolazzi, Luis H. Eraso, Paul J. Dimuzio, Massimo Massetti, Antonio Gasbarrini, Andrea Flex

Department of Surgery Faculty Papers

Individuals with chronic inflammatory and immune disorders are at an increased risk of atherosclerotic events and premature cardiovascular (CV) disease. Despite extensive literature exploring the relationship between "non-traditional" atherosclerotic conditions and CV risk, many aspects remain unresolved, including the underlying mechanisms promoting the "non-traditional CV risk", the development of an innovative and comprehensive CV risk assessment tool, and recommendations for tailored interventions. This review aims to evaluate the available evidence on key "non-traditional" CV risk-enhancer conditions, with a focus on assessing and managing CV risk factors. We conducted a comprehensive review of 412 original articles, narrative and systematic reviews, and …

Effect Of Resin Restorative Material Type And Layering Techniques On The Fracture Resistance Of Maxillary Premolars, Mohamed Fouad Haridy, Radwa Ahmed Nagy, Shimaa El-Sayed El-Husseiny

Dentistry

No abstract provided.

Alzheimer’S Disease: Relationship Of Cognition And Behavior To Neurochemistry, Peter J. Whitehouse

Faculty Scholarship

Alzheimer’s disease is characterized by loss of cells and synapses in specific neural systems. The development of more effective therapies will depend on understanding the relationships between this pathology and the cognitive and behavioral impairments. In this review, focusing primarily on work in our laboratory, we will examine both classic and neuropeptide neurotransmitter systems and will discuss conceptual and methodological problems in relating clinical and biological measures.

Securing A Virtual Reality Classroom Using Unity, Okemute Samuel Idonor

Theses and Dissertations

This study examines how security features might be incorporated into a Unity created virtual reality (VR) classroom, with a particular emphasis on important concerns including user privacy, data security, and illegal access. The increasing usage of virtual reality (VR) technology in educational settings has made it crucial to ensure the security of these immersive systems, especially when it comes to safeguarding sensitive user data. Designing and implementing a secure VR classroom prototype that could successfully protect against common security concerns, such as unauthorized access and data breaches, was the main goal of this project. Multi-Factor Authentication (MFA), Role-Based Access Control …

Between Pedagogical Content Knowledge And Confidence: A Case Study Of Pronunciation Training And Teacher Preparation, Lena Barrantes-Elizondo, Joshua Gordon

Faculty Publications

While many teachers do not feel confident teaching pronunciation because of limited preparation in different areas, research has demonstrated positive effects of training in pronunciation pedagogy, as teachers who receive such training develop cognitions (i.e., knowledge, beliefs, thoughts, actions) that align with current tenets of pronunciation pedagogy. Drawing on this assertion, this paper reports the results of a qualitative case study with five pre-service teaching-English-to-speakers-of-other-languages (TESOL) teachers enrolled in a pedagogical pronunciation course as part of their teacher training program. The study’s main purpose was to understand the role of training in developing content knowledge (CK) and pedagogical content knowledge …

Mathematics In Everyday Life: Exploring Practical Applications And Real-World Impact, Priyant Banerjee, Arshad Bhat

Himalayan Research Papers Archive

Mathematics is an essential part of daily life and influences decisions and problem-solving in various aspects of life. This study explores how mathematical concepts are embedded in daily activities such as financial management, cooking, travel planning, and technological interactions. We will show how arithmetic, algebra, geometry, and statistics are applied in real life to improve decision-making, efficiency, and productivity. Findings indicate that people with higher mathematical literacy solve problems more efficiently, especially in budgeting, as accurate calculations minimize financial mistakes and facilitate long-term financial planning. In cooking, proportional reasoning ensures the accuracy of recipes, thus providing consistent culinary results. Travel …

The State Of Global And African Ecology, Peter Knox

Landas

This article recounts the growth of concern for the environment in the latter half of the 20th Century, and its entry into Catholic magisterial theology. It expands on the ecological theory of planetary boundaries, and identifies how the theory surfaces in Pope Francis’ 2015 encyclical Laudato Si’. Based upon solid contemporary science, the encyclical is well founded to outline an appropriate and compassionate moral theology of care for creation. The article cites multiple instances where African people are at the nexus of environmental and social crises, focusing on how contemporary ecological factors affect women in particular. Environmental crises should not …

Peripheral Extracellular Vesicles For Diagnosis And Prognosis Of Resectable Lung Cancer: The Lucex Study Protocol, Jorge Rodríguez-Sanz, Nadia Muñoz-González, José Pablo Cubero, Pablo Ordoñez, Victoria Gil, Raquel Langarita, Myriam Ruiz, Marta Forner, Marta Marín-Oto, Elisabet Vera, Pedro Baptista, Francesca Polverino, Juan Antonio Domingo, Javier García-Tirado, José María Marin, David Sanz-Rubio

Faculty, Staff and Students Publications

Background/Objectives: Lung cancer is the primary cause of cancer-related deaths. Most patients are typically diagnosed at advanced stages. Low-dose computed tomography (LDCT) has been proven to reduce lung cancer mortality, but screening programs using LDCT are associated with a high number of false positives and unnecessary thoracotomies. It is therefore imperative that a certain diagnosis is refined, especially in cases of solitary pulmonary nodules that are difficult to technically access for an accurate preoperative diagnosis. Extracellular vesicles (EVs) involved in intercellular communication may be an innovative biomarker for diagnosis and therapeutic strategies in lung cancer, regarding their ability to carry …

Perceptions Of Law Enforcement Spouses Regarding Officer Safety And Danger, Heidi Marie Rose

Walden Dissertations and Doctoral Studies

Policing is a stressful and dangerous occupation that is imperative to a functioning society, and stress should be limited to ensure a healthy mind and body. The purpose of this study was to examine the perceptions of law enforcement spouses regarding officer safety and danger, which was lacking in the research. Law enforcement spouses have a significant impact over the stress levels of their loved ones. The work–life balance and work–family conflict theories were the theoretical framework used to relate to the study and support the research. The generic qualitative design was used with semistructured interviews to gather research data …

Perceptions Of Law Enforcement Spouses Regarding Officer Safety And Danger, Heidi Marie Rose

Walden Dissertations and Doctoral Studies

Policing is a stressful and dangerous occupation that is imperative to a functioning society, and stress should be limited to ensure a healthy mind and body. The purpose of this study was to examine the perceptions of law enforcement spouses regarding officer safety and danger, which was lacking in the research. Law enforcement spouses have a significant impact over the stress levels of their loved ones. The work–life balance and work–family conflict theories were the theoretical framework used to relate to the study and support the research. The generic qualitative design was used with semistructured interviews to gather research data …

Effectiveness Of Natural Coagulants In Purification Of Industrial Wastewater: A Case Of Cactus Pads And Watermelon Seeds, Neema O. Msuya

Tanzania Journal of Engineering and Technology (TJET)

This study assessed the potential of cactus pads and watermelon seeds as natural coagulants in industrial wastewater treatment. The global characterization of the two coagulants was done by using the Fourier Transform Infrared (FTIR) to determine the specific functional groups and by zeta potential measurements. A full factorial design was used to design the experiment and analyze the effect of three factors: coagulant dosage, settling time and particle size with three levels each and one replicate on the turbidity removal. ANOVA analyses were used to determine the significance of the factors. Results show that the amino and hydroxyl groups in …

Use Of Activated Palm Kernel Shells On Adsorption Of Heavy Metals (Cu2+ And Pb2+) From Contaminated Wastewater, Edwin N. Richard

Tanzania Journal of Engineering and Technology (TJET)

This research aimed to evaluate the adsorption capacity of low-cost agricultural waste adsorbent-activated palm kernel shells (APKS) for the removal of Pb2+ and Cu2+ ions from synthetic wastewater that had the concentration of copper and lead ions comparable to that of waste produced in Tanzanian research and teaching laboratories. This study was carried out in batch and continuous column adsorption reactors. The study examined the influence of particle size (0.71 mm–2.36 mm), pH (4.5–8.6), adsorbent dose (5–20 mg/L) and initial concentration Ci (1.93– 4 mg/l) on APKS adsorption removal efficiency. The batch results indicated that under alkali conditions (pH 8.4 …

Retraction: A Case Report Of Grisel's Syndrome Complicating The Postoperative Course Of Craniotomy For A Massive Cystic Brain Lesion, Takara R. Newsome-Cuby, Kwadwo Darko, Peace Odiase, Sean O'Leary, Charles R. Marchese, Michael J. Valentine, Benjamin J. Pautler, Usama Aldallal, Mohamed Ismail, Fakhar Hayat

Student Publications

No abstract provided.

The Role Of Exosomes In Medical Dermatology: Literature Review And Update, Victoria Dukharan, Milaan Shah, Luke Broughton, Carol Stegura, Luna Samman, Nina Schur, Jacqueline M. Luna, Daniela Gutierrez Mendoza, José Ramón García Lira, Adriana María Valencia-Herrera, Jona Louise D. Macaraeg-Jimenez, Victoria G. Belo, Regina Gabrielle Gatan, Suparuj Lueangarun, Ana Cecilia Amador Ruiz, Karolina Ziemlewski, Zuramis Estrada Blanco, Todd Schlesinger

GME Publications

Background

Exosomes are extracellular vesicles, composed of a phospholipid bilayer, that are primarily derived from stem cells. The contents of exosomes can be incorporated into the tissue in which they are introduced, which presents a unique therapeutic option.

Aims

Exosomes have been investigated as a treatment for a number of medical ailments, but the literature supporting these indications is inconclusive. In addition, much of the study on exosomes and their uses has been recently completed. Thus, this review summarizes the efficacy and implications of exosomes in the treatment of different dermatologic conditions.

Methods

A literature review surrounding the use of …

Molecular Dynamics At Immune Synapse Lipid Rafts Influence The Cytolytic Behavior Of Car T Cells, Ahmed Z Gad, Jessica S Morris, Lea Godret-Miertschin, Melisa J Montalvo, Sybrina S Kerr, Harrison Berger, Jessica C H Lee, Amr M Saadeldin, Mohammad H Abu-Arja, Shuo Xu, Spyridoula Vasileiou, Rebecca M Brock, Kristen Fousek, Mohamed F Sheha, Madhuwanti Srinivasan, Yongshuai Li, Arash Saeedi, Kandice R Levental, Ann M Leen, Maksim Mamonkin, Alexandre Carisey, Navin Varadarajan, Meenakshi Hegde, Sujith K Joseph, Ilya Levental, Malini Mukherjee, Nabil Ahmed

Faculty, Staff and Students Publications

Chimeric antigen receptor T cells (CART) targeting CD19 through CD28.ζ signaling induce rapid lysis of leukemic blasts, contrasting with persistent tumor control exhibited by 4-1BB.ζ-CART. We reasoned that molecular dynamics at the CART immune synapse (CARIS) could explain differences in their tumor rejection kinetics. We observed that CD28.ζ-CART engaged in brief highly lethal CARIS and mastered serial killing, whereas 4-1BB.ζ-CART formed lengthy CARIS and relied on robust expansion and cooperative killing. We analyzed CARIS membrane lipid rafts (mLRs) and found that, upon tumor engagement, CD28.ζ-CAR molecules rapidly but transiently translocated into mLRs, mobilizing the microtubular organizing center and lytic granules …

Pembrolizumab Plus Chemotherapy In Frontline Treatment Of Advanced Ovarian Cancer: Clinical And Translational Results From A Phase 2 Trial, Jeffrey A How, Minghao Dang, Sanghoon Lee, Bryan Fellman, Shannon N Westin, Anil K Sood, Nicole D Fleming, Aaron Shafer, Ying Yuan, Jinsong Liu, Li Zhao, Joseph Celestino, Richard Hajek, Margaret B Morgan, Edwin R Parra, Caddie D Laberiano Fernandez, Claudio A Arrechedera, Luisa Maren Solis Soto, Kathleen M Schmeler, Alpa Nick, Karen H Lu, Robert Coleman, Linghua Wang, Amir A Jazaeri

Faculty, Staff and Student Publications

Background: The efficacy and feasibility of pembrolizumab combined with chemotherapy in frontline management of advanced high-grade epithelial ovarian cancer (EOC) is unknown. Additionally, modification of the tumor microenvironment following neoadjuvant therapy is not well understood.

Methods: In this single-arm phase 2 trial (this study was registered at ClinicalTrials.gov: NCT02520154), eligible patients received up to 4 cycles of neoadjuvant chemotherapy followed by interval cytoreduction, 3 cycles of adjuvant intravenous carboplatin/weekly paclitaxel/pembrolizumab, and finally maintenance pembrolizumab until progression or toxicity (maximum 20 cycles). The primary endpoint was progression-free survival (PFS). Secondary endpoints included feasibility, toxicity, and overall survival (OS). PD-L1 staining, …

Sitravatinib In Combination With Nivolumab Plus Ipilimumab In Patients With Advanced Clear Cell Renal Cell Carcinoma: A Phase 1 Trial, Pavlos Msaouel, Kai Yu, Ying Yuan, Jianfeng Chen, Xinmiao Yan, Menuka Karki, Fei Duan, Rahul A Sheth, Priya Rao, Kanishka Sircar, Amishi Y Shah, Amado J Zurita, Giannicola Genovese, Min Li, Chih-Chen Yeh, Minghao Dang, Guangchun Han, Yanshuo Chu, Max Hallin, Peter Olson, Rui Yang, Daniela Slavin, Hirak Der-Torossian, Curtis D Chin, Nizar M Tannir, Linghua Wang, Jianjun Gao

Faculty, Staff and Student Publications

We conducted a phase I trial to determine the optimal dose of triplet therapy with the tyrosine kinase inhibitor sitravatinib plus nivolumab plus ipilimumab in 22 previously untreated patients with advanced clear cell renal cell carcinoma. The primary endpoint was safety. Secondary endpoints were objective response rate (ORR), disease control rate (DCR), duration of response (DOR), progression-free survival (PFS), overall survival (OS), 1-year survival probability, and sitravatinib pharmacokinetics. Sitravatinib dose of 35 mg daily plus nivolumab 3 mg/kg and ipilimumab 1 mg/kg resulted in high frequency of immune-related adverse events. Subsequent dose reduction of ipilimumab to 0.7 mg/kg allowed safe …

Superstable Lipid Vacuoles Endow Cartilage With Its Shape And Biomechanics, Raul Ramos, Kim T Pham, Richard C Prince, Leith B Leiser-Miller, Maneeshi S Prasad, Xiaojie Wang, Rachel C Nordberg, Benjamin J Bielajew, Jerry C Hu, Kosuke Yamaga, Ji Won Oh, Tao Peng, Rupsa Datta, Aksana Astrowskaja, Axel A Almet, John T Burns, Yuchen Liu, Christian Fernando Guerrero-Juarez, Bryant Q Tran, Yi-Lin Chu, Anh M Nguyen, Tsai-Ching Hsi, Norman T-L Lim, Sandra Schoeniger, Ruiqi Liu, Yun-Ling Pai, Chella K Vadivel, Sandy Ingleby, Andrew E Mckechnie, Frank Van Breukelen, Kyle L Hoehn, John J Rasweiler, Michinori Kohara, William J Loughry, Scott H Weldy, Raymond Cosper, Chao-Chun Yang, Sung-Jan Lin, Kimberly L Cooper, Sharlene E Santana, Jeffrey E Bradley, Michael A Kiebish, Michelle Digman, David E James, Amy E Merrill, Qing Nie, Thomas F Schilling, Aliaksandr A Astrowski, Eric O Potma, Martín I García-Castro, Kyriacos A Athanasiou, Richard R Behringer, Maksim V Plikus

Faculty, Staff and Student Publications

Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine cartilages consist of lipid-filled cells called lipochondrocytes. Despite resembling adipocytes, lipochondrocytes were molecularly distinct and produced lipids exclusively through de novo lipogenesis. Consequently, lipochondrocytes grew uniform lipid droplets that resisted systemic lipid surges and did not enlarge upon obesity. Lipochondrocytes also lacked lipid mobilization factors, which enabled exceptional vacuole stability and protected cartilage from shrinking upon starvation. Lipid droplets modulated lipocartilage biomechanics by decreasing the tissue's stiffness, strength, and resilience. Lipochondrocytes were found in multiple mammals, including humans, …

Differential Encoding Of Mammalian Proprioception By Voltage-Gated Sodium Channels, Cyrrus M. Espino, Chetan Nagaraja, Serena Ortiz, Jacquelyn R. Dayton, Akash R. Murali, Yanki Ma, Emari L. Mann, Snigdha Garlapalli, Ross P. Wohlgemuth, Sarah E. Brashear, Lucas R. Smith, Katherine A. Wilkinson, Theanne N. Griffith

Faculty Research, Scholarly, and Creative Activity

Animals requiring purposeful movement for survival are endowed with mechanoreceptors, called proprioceptors, that provide essential sensory feedback from muscles and joints to spinal cord circuits, which modulates motor output. Despite the essential nature of proprioceptive signaling in daily life, the mechanisms governing proprioceptor activity are poorly understood. Here, we identified nonredundant roles for two voltage-gated sodium channels (NaVs), NaV1.1 and NaV1.6, in mammalian proprioception. Deletion of NaV1.6 in somatosensory neurons (NaV1.6cKO mice) causes severe motor deficits accompanied by loss of proprioceptive transmission, which contrasts with our previous findings using similar mouse models to target NaV1.1 (NaV1.1cKO). In NaV1.6cKO animals, we …

Literacy Skills And Practices In Cambodian-American Families: A Portraiture Of Ten Women, Sothy Tep

Journal of Southeast Asian American Education and Advancement

Abstract:This research article describes the literacy skills and practices in ten Cambodian-American (CA) families within their home environment. It also investigates such contextual problems as CA students not being a part of the Asian model minority and the invisibility that some experience at school.Its literature review addresses the evolving concept of family literacy scholarship, specifically diversity scholarship, with a conceptual framework focusing on Dewey’s (1916) ideas linking family literacy ultimately to human empowerment, hope, progress, growth, and meaning within society. A narrative inquiry technique called portraiture is employed to collect the data of its ten participants’ …

Samsara, Colin Borgen

Floodwall Magazine

No abstract provided.

Coffee Shop Masquerade, Nauman Farid

Floodwall Magazine

No abstract provided.

Quality Risk Management: A Role-Based Competency Model For The Biopharmaceutical Sector, Ghada Haddad

Journal of Applied Pharmaceutical Regulatory Science

In 2005, the International Conference on Harmonisation’s (ICH’s) ‘’Q9’’, aimed at providing the biopharmaceutical sector with guidance towards a science and risk-based approach to quality management was published. The concepts outlined in ICH Q9 focused on the fact that evaluation of the risk to quality should be based on scientific knowledge and ultimately link to the protection of the patient.

The purpose of ICH Q9 is to offer a systematic approach to quality risk management (QRM). It serves as a foundation or resource document that is independent of yet supports other ICH Quality documents and complements existing quality practices, requirements, …

Taking A Stand For Quality: Demonstrating Pqs Effectiveness By Operationalizing Qrm And Km, Kevin O'Donnell, Martin J. Lipa, Anne Greene (Editor)

Journal of Applied Pharmaceutical Regulatory Science

While the authors have published widely on the need to unite the twin enablers of ICH Q10 [1], quality risk management (QRM) and knowledge management (KM), how to integrate QRM and KM in practice has proven to be quite challenging. QRM and KM are wide-ranging activities that impact many elements of pharmaceutical manufacturing and regulation. Pharmaceutical manufacturers and their regulators work to apply risk-based approaches to their work and strive to use knowledge in a smart and efficient way, but so far, in the experience of the authors, it has proven difficult to get these things right.

One way to …

Towards A New Era Of Surgery Using Intelligent Robot, Ahmed Mahfouz, Hassan A. El Gamal, T. Awad, M.B. Badawi

Journal of Engineering Research

This research aims to overcome the difficulties of surgical tumor removal, especially in brain tumors that needs precision and time saving of the operations. The traditional surgical approach often is slow and targeting accurate manual cutting of the tumor, which is time-consuming and increase the risk to the patient. The error in cutting the deep layers of the tumor can occur, which increase the cost and dangerous for the patient.

To overcome these challenges, a proposed solution involves designing a robot that can quickly and accurately remove tumors by following their contours as it comes from the medical imaging data, …

A Non-Standard Finite Difference Approach For Optimizing The Thermal Behaviour Of Photovoltaic Panel With Hybrid Cooling Techniques, E.F. El-Gazar, A.A Hawwash, Hamdy Hassan, Shinsuke Mori, Ayman Refat Abd Elbar

Journal of Engineering Research

A finite difference model is developed to simulate the thermal behaviour of the PV system with an innovative cooling system. The proposed cooling system combines an aluminium heat spreader (AHS) with phase change material (PCM) placed at the backside of the solar panel. The new non-standard model is solved using MATLAB software and is validated with real experimental data collected under hot climate conditions. The new nonlocal model is found to be more effective in analyzing heat transfer processes throughout the entirety of the PV system compared to conventional PV models. Additionally, the new cooling PV system has been compared …

Assessment Of Physical And Ergonomic Hazards And Their Compliance With National Standards. A Case Study, Amira Abdelraheem

Journal of Engineering Research

Occupational hazards are a significant concern in high-risk environments such as petroleum operating companies, where workers are exposed to various risks, including chemical, physical, mechanical, ergonomic, and psychosocial factors. Effective management of these hazards is essential to protect the health and safety of employees and maintain operational efficiency. This study aims to assess physical hazards including a-weighted equivalent noise levels, heat stress, Lightning and Ergonomics in a petroleum operating company in Egypt, and to check its conformity with national standards. Physical environment (Noise, heat stress and illumination) in different worksites were assessed using calibrated direct reading instruments to evaluate the …

Lessons Learned From The Covid-19 Pandemic Crisis Management In The Gaza Strip: A Qualitative Study., Belal Aljamal

Journal of the Arab American University مجلة الجامعة العربية الامريكية للبحوث

Aims of the study: The main aim of this study was to discover the lessons learned from the COVID-19 pandemic crisis management from health policymakers' perspective in the Gaza Strip. Methods: The researcher used a qualitative design, targeting 25health policymakers using a purposeful sampling technique and face-to-face semi-structured interviews to collect data. To analyze the interview data, the directed qualitative content analysis approach was used.

Results: All interviewees agreed that the Palestinian Ministry of Health (MoH) managed the COVID-19pandemic well despite the insufficient resources and lack of experience. More specifically, the average of most participants’ assessments of Palestinian MoH “Preparedness” …