Digital Commons Network^™

Swog S1815: A Phase Iii Randomized Trial Of Gemcitabine, Cisplatin, And Nab-Paclitaxel Versus Gemcitabine And Cisplatin In Newly Diagnosed, Advanced Biliary Tract Cancers, Rachna T Shroff, Benjamin Tan, Et Al.

2020-Current year OA Pubs

PURPOSE: SWOG S1815 was a randomized, open label phase III trial, evaluating gemcitabine, nab-paclitaxel, and cisplatin (GAP) versus gemcitabine and cisplatin (GC) in patients with newly diagnosed advanced biliary tract cancers (BTCs).

METHODS: Patients with newly diagnosed locally advanced unresectable or metastatic BTC, including intrahepatic cholangiocarcinoma (ICC) and extrahepatic cholangiocarcinoma (ECC) and gallbladder carcinoma (GBC), were randomly assigned 2:1 to either GAP (gemcitabine 800 mg/m

RESULTS: Among 452 randomly assigned participants, 441 were eligible and analyzable, 67% with ICC, 16% with GBC, and 17% with ECC. There was no significant difference in overall survival (OS) between GAP versus GC. Median …

Structural Features And Morphology Of Biodegradable Composites Based On Polylactide And Corn Starch, Eygeniy N. Poddenezhny, Andrei A. Boiko, Ekaterina E. Trusova, Viktor M. Shapovalov

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the work was to study the morphology and structural features of biodegradable composites based on polylactide, filled with corn starch formed by extrusion method. The characteristics of the obtained materials were investigated by scanning electron microscopy, X-ray diffraction, IR spectroscopy. It was established that the presence of polyethylene glycol PEG–4000 as a plasticizer and surfactant – glycerin monostearate in the initial mixture leads to the formation of a nonporous heterogeneous system, in which starch particles are statistically distributed in the matrix. The starch concentration in the composite varied from 20 to 55 wt. %. When the starch …

Library Staff Perceptions Of Virtual Library And Information Services At Makerere And Uganda Christian Universities, Uganda, Lydia Namugera, Joyce Bukirwa, Constant Okello-Obura

Library Philosophy and Practice (e-journal)

This study, which was underpinned by the ServQual model aims to determine the perceptions of library staff of Makerere and Uganda Christian Universities on the provision of virtual library and information services (VLIS), the challenges faced and strategies for the enhancement of VLIS provision. A qualitative design was used to collect data from eight library staff who were selected through purposive sampling until data reached saturation. The findings indicated that majority of librarians exhibit poor perceptions towards VLIS; as manifested in their reluctance to participate in VLIS provision, their conservatism, which impedes acceptance of new VLIS and their …

Evaluation Of Glass Ionomer With Advanced Glass Hybrid Technology Versus Resin Modified Glass Ionomer In Adult Patients With Carious Cervical Lesions After One Year: A Randomized Clinical Trial., Aya Magdy Zayed, ِAhmed Zoheir El Hoshy, Mohamed Refaat El-Bialy

Future Dental Journal

Aim: Compared the clinical performance by using Advanced Glass Hybrid technology glass ionomer (AGH) in cervical carious lesion, versus resin modified glass ionomer (RMGI) according to modified USPHS criteria over one year. Materials and methods: An overall of 32 elevated carious index adult patients with at least one carious class V cavity on their posterior teeth had been split into 2 equal groups randomly based on the received restoration system. Two pairs of restorations were used, either; Equia Forte HT Fill (AGH) or Fuji II LC (RMGI), both materials were employed in accordance with the manufacturer's guidelines. Fillings have …

P53 Tumor Suppressor Gene Expression In Ameloblastoma Subtypes: An Immunohistochemical Analysis, Yara Y. Mouselhy, Ahmed Abozekry, Iman M. Abdel Meguid, Raneem F. Obeid, Mai Abdelhalim Hamouda, Hala El-Kammar

Future Dental Journal

Background: Ameloblastoma is the most frequent of the benign epithelial odontogenic tumours. It exhibits a unique biologic behavior which demands meticulous understanding for thorough diagnosis and management. P53 tumor suppressor protein functions as a gatekeeper of cell division, inducing either cell cycle arrest or apoptosis. While mutations in the p53 gene are often detected in human cancers; the role of p53 in ameloblastoma remains elusive.

Material and methods: To investigate p53 expression in ameloblastoma, a retrospective study was designed to evaluate and compare immunohistochemical p53 protein expression patterns, in follicular ameloblastoma, plexiform ameloblastoma and unicystic ameloblastoma. Nine paraffin-embedded archival tissue …

The Effect Of Nanoparticles Incorporation On Antimicrobial And Bond Strength Properties Of Bio-Ceramic Sealer (An In Vitro Study), Hatem Tarek Dr., Wael Hussein Kamel Prof., Nehal Ezzat Sabet Prof., Adel Abdelwahed Associate Prof.

Future Dental Journal

Aim: This research intended to assess how the addition of nanoparticles impacts the antimicrobial effectiveness and bonding ability of bio-ceramic sealers when compared to resin-based sealers.. Materials and Methods: Bioactive glass nanoparticles (BG NPs) were prepared via a modified Stöber process. AH Plus and Bio-C Sealer were mixed with (BG NPs). Part I: Antibacterial tests involved 96 tubes divided into 6 main groups , tests were conducted using Enterococcus faecalis using direct contact test (DCT). Part II: Push-out tests utilized 32 extracted human permanent anterior teeth and were performed to evaluate bond strength. Results: Resin-based sealers and bio-ceramic sealers exhibited …

African American Male Reluctance In Teacher Education, Michael L. Williams

Mid-Western Educational Researcher

There is a shortage of teachers among rapidly expanding populations of culturally diverse students in K-12 education. Minority students enrolled in public schools have been rising while the number of minority teachers has been falling. Twenty percent of teachers are from ethnic and racial backgrounds, however, schools educate majority-minority populations. What is most troubling, is that the most negatively impacted student of K-12 diverse populations is African-American males. This commentary focuses on the fact that there are initiatives and ideas to close the teacher diversity gap by creating pipelines of African American male teachers. However, the effort it takes to …

Unm Hsc Education & Ipe Day Agenda 2025, Office For Continuous Professional Learning (Cpl)

HSC Education Days

No abstract provided.

Life History, Reproductive, And Demographic Parameters For Bottlenose Dolphins (Tursiops Truncatus) In Sarasota Bay, Florida, Randall S. Wells, Aleta A. Hohn, Michael D. Scott, Jay C. Sweeney, Forrest I. Townsend, Jason B. Allen, Aaron A. Barleycorn, Katherine A. Mchugh, Kim Bassos-Hull, Gretchen N. Lovewell, Deborah A. Duffield, Cynthia R. Smith, A. Blair Irvine

Biology Faculty Publications and Presentations

Studies of the resident community of bottlenose dolphins (Tursiops truncatus) of Sarasota Bay, Florida, have been conducted for more than 50 years. Detailed histories have been collected for resident individuals through integrated observations, systematic photographic identification surveys, tagging and tracking, catch-and-release health assessments, remote biopsy sampling, and stranding response. This has produced a unique dataset documenting life history milestones and vital rates of a small cetacean. Analyses of data from 482 resident Sarasota Bay dolphins have revealed estimated maximum life spans of 67 years for females and 52 years for males. For females, predicted age at sexual maturation …

Transhumanism And Artificial Personality, John D. Mayer

UNH Personality Lab

No abstract provided.

Assessing The Usefulness Of Solid-Phase Microextraction (Spme) For Methadone And Its Metabolites Analysis In Urine Samples Using Hplc/Spme Fibre Tips, Majidah Mahmoud Alfahmi

Saudi Toxicology Journal

Solid-phase microextraction (SPME) has been introduced as a novel, simple and single- step technique of extracting methadone (MDN), 2-ethylidene-1,5-dimethyl-3,3- diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline (EMDP) from urine samples. In this study, direct immersion SPME followed by high-performance liquid chromatography with ultraviolet detection (HPLC-UV) was developed to identify methadone and its metabolites. The separation was performed on a Gemini C18 (octadecyl carbon chain) analytical column (150 x 2.0 mm, 5 µm) and detected by an ultraviolet (UV) detector at 210 nm. The factors influencing the SPME procedure, such as the sample’s pH, fibre coating type, salt addition and desorption solvent type were …

Atsubp-2.0: An Integrated Web Server For The Annotation Of Arabidopsis Proteome Subcellular Localization Using Deep Learning, Naveen Duhan, Rakesh Kaundal

Plants, Soils and Climate Student Research

The organization of subcellular components in a cell is critical for its function and studying cellular processes, protein–protein interactions, identifying potential drug targets, network analysis, and other systems biology mechanisms. Determining protein localization experimentally is time-consuming and expensive. Due to the need for meticulous experimentation, validation, and data analysis, computational methods provide a quick and accurate alternative. Arabidopsis thaliana, a beneficial model organism in plant biology, facilitates experimentation and applies to other plants. Predicting its proteins' subcellular localization can improve our understanding of cellular processes and have applications in crop improvement and biotechnology. We propose AtSubP-2.0, an extension of …

Hidradenitis Suppurativa Is Associated With An Increased Risk Of Adverse Cardiac Events And All-Cause Mortality, Thomas Z. Rohan, Ramsay Hafer, Teresa Duong, Rishob Dasgupta, Sherry Yang

Department of Dermatology and Cutaneous Biology Faculty Papers

Background: Hidradenitis suppurativa (HS) has been previously associated with greater rates of major adverse cardiac events (MACEs) compared to the general population. This study aims to better elucidate the association between HS, MACEs, and other cardiovascular diseases. Methods: We utilized TriNetX, a global database of electronic health records, to conduct a retrospective cohort study. HS patients were matched on demographic and cardiovascular disease risk factors to both healthy and psoriasis groups as controls. Results: After adjusting for cardiovascular disease risk factors, HS patients had a relative risk (RR) (95% CI) of 2.06 (1.83-2.32) for myocardial infarction, 1.62 …

Laws On Pandemic Response: The Inventory In Light Of Covid-19, Devika Tadwalkar

Journal of Law and Public Policy

No abstract provided.

A Tale Of Diplomacy And Equity: India’S Strive Towards Covid-19 Vaccine Pricing And Procurement, Samrudh Kopparam

Journal of Law and Public Policy

No abstract provided.

Vaccine Crisis And Patent Rights—Issues And Challenges: A Global Perspective, Kshitij Kumar Rai, Sakshi Agarwal

Journal of Law and Public Policy

No abstract provided.

Kate Fields Full Interview Transcript, Urban Green Lab, Tennessee State University

Hear from Kate Fields - Native Nashvillian Feeding the Flocks

No abstract provided.

An Ontology-Based Rare Disease Common Data Model Harmonising International Registries, Fhir, And Phenopackets., Adam S L Graefe, Miriam R Hübner, Filip Rehburg, Steffen Sander, Sophie A I Klopfenstein, Samer Alkarkoukly, Ana Grönke, Annic Weyersberg, Daniel Danis, Jana Zschüntzsch, Elisabeth F Nyoungui, Susanna Wiegand, Peter Kühnen, Peter N Robinson, Oya Beyan, Sylvia Thun

Faculty Research 2025

Although rare diseases (RDs) affect over 260 million individuals worldwide, low data quality and scarcity challenge effective care and research. This work aims to harmonise the Common Data Set by European Rare Disease Registry Infrastructure, Health Level 7 Fast Healthcare Interoperability Base Resources, and the Global Alliance for Genomics and Health Phenopacket Schema into a novel rare disease common data model (RD-CDM), laying the foundation for developing international RD-CDMs aligned with these data standards. We developed a modular-based GitHub repository and documentation to account for flexibility, extensions and further development. Recommendations on the model's cardinalities are given, inviting further refinement …

Carboxymethyl Cellulose Assisted Reforming Of Poly Acrylic Acid Co Methyl Methacrylate Composite For Wastewater Treatment And Effective Hosting Of Antimicrobial Silver, Ahmed Mokhtar, Hassan Nageh, Salah Abdo Hassan, Mohamed Mekewi, Atef Samir Darwesh

Dentistry

Herein, novel polymer composite is fabricated by hybridizing poly (acrylic acid-co-methyl methacrylate) filaments with carboxymethyl cellulose, which efficiently reorients and strictly ties the fibrous chains to form polymeric units of plate-like morphology. This innovative hybrid polymer composite is analyzed using XRD, FT-IR, swelling and contact angle studies, DLS, AFM, and SEM. Removal efficiency of such polymer composite is scrutinized in colored wastewater treatment. Langmuir and pseudo-first-order kinetic models best describe safranine dye removal from wastewater, adopting exothermic adsorption progression with elevated capacity (~ 59.47 mg/g) and accelerated rate (~ 1.06 h− 1). Such polymer composite exhibits persistent removal efficiency of …

Exploring The Connection Between Rna Splicing And Intellectual Disability, Anthony Caputo, Ashleigh E. Schaffer

Faculty Scholarship

Intellectual disability (ID) is a broad diagnostic category that encompasses individuals with impaired cognitive ability. While these disorders have heterogeneous causes, recent developments in next-generation sequencing (NGS) are revealing the prevalence of genetic etiologies. In particular, germline mutations in genes that affect RNA splicing are increasingly common causes of ID disorders. Research to elucidate the functional relationship between splicing and neurodevelopment is critical since molecular therapeutics require a nuanced understanding of the pathological mechanism. In this review, we first summarize the trends that have led to the discovery of the RNA splicing–ID relationship, then discuss recent progress and future directions …

Exploring The Relationship Between Psychiatric Illness And Dermatological Disorders: A Narrative Review, Alan D. Kaye, Rahib K. Islam, Abigayle M. Castine, Grace C. Wester, William T. Barham, Catherine G. Nguyen, Elena Plakotaris, Bradley Dorius, Julian Kim, Patricia Griffin, Amber Edinoff, Sahar Shekoohi, Giustino Varrassi

School of Medicine Faculty Publications

The interplay between psychiatric conditions and dermatological disorders is complex and multifaceted, often resulting in significant challenges for both diagnosis and treatment. This narrative review examines associations between specific psychiatric conditions, trichotillomania, attention deficit hyperactivity disorder, schizophrenia, bipolar disorder, and various dermatological disorders. The present investigation delves into pathophysiological mechanisms, clinical presentations, and management strategies of these comorbid conditions. Psychiatric disorders can exacerbate dermatological conditions through mechanical trauma, medication side effects, and stress-induced exacerbations, while dermatological disorders can lead to significant psychiatric morbidity. The biopsychosocial approach, emphasizing the importance of integrated care involving dermatologists and mental health professionals, is crucial …

Quantitative Characterization And Prediction Of The Binding Determinants And Immune Escape Hotspots For Groups Of Broadly Neutralizing Antibodies Against Omicron Variants: Atomistic Modeling Of The Sars-Cov-2 Spike Complexes With Antibodies, Mohammed Alshahrani, Vedant Parikh, Brandon Foley, Nishank Raisinghani, Gennady M. Verkhivker

Mathematics, Physics, and Computer Science Faculty Articles and Research

A growing body of experimental and computational studies suggests that the cross-neutralization antibody activity against Omicron variants may be driven by the balance and tradeoff between multiple energetic factors and interaction contributions of the evolving escape hotspots involved in antigenic drift and convergent evolution. However, the dynamic and energetic details quantifying the balance and contribution of these factors, particularly the balancing nature of specific interactions formed by antibodies with epitope residues, remain largely uncharacterized. In this study, we performed molecular dynamics simulations, an ensemble-based deep mutational scanning of SARS-CoV-2 spike residues, and binding free energy computations for two distinct groups …

Large Range Sizes Link Fast Life Histories With High Species Richness Across Wet Tropical Tree Floras, Timothy R. Baker, Stephen Adu-Bredu, Kofi Affum-Baffoe, Shin-Ichiro Aiba, Sophie Fauset, Perpetra Akite, Miguel Alexiades, Everton Almeida, Edmar Almeida De Oliveira, Esteban Alvarez Davila, Christian Amani, Ana Andrade, Luiz Aragao, Alejandro Araujo-Murakami, Eric Arets, Luzmila Arroyo, Peter Ashton, Suspense A. Averti Ifo, Gerardo A. C. Aymard, Michel Baisie, William Balee, Michael Balinga, Lindsay F. Banin, Olaf Banki, Christopher Baraloto, Jorcely Barroso, Hans Beeckman, Jean-Francois Bastin, Serge Begne, Natacha Nssi Bengone

School of Geography, Earth and Environmental Sciences

Understanding how the traits of lineages are related to diversification is key for elucidating the origin of variation in species richness. Here, we test whether traits are related to species richness among lineages of trees from all major biogeographical settings of the lowland wet tropics. We explore whether variation in mortality rate, breeding system and maximum diameter are related to species richness, either directly or via associations with range size, among 463 genera that contain wet tropical forest trees. For Amazonian genera, we also explore whether traits are related to species richness via variation among genera in mean species-level range …

Legal Dimensions Of Rights Of Nature Applied In The Context Of The River Plym: River Plym Project Phase 1 Appendix, Jason Lowther

School of Law, Humanities and Social Sciences

This review of the literature and legal framing of so-called river rights – loosely understood by reference to the extension of certain characteristics or a particular status upon the river – has been collated in the context of the River Plym-citizenship advocacy project. It aims to examine the legal and policy potential for the attribution of ‘rights’ upon the River Plym. It does so by outlining the challenges facing the waterway, in common with many others, and noting the limitations of the current regulatory systems applied to it. The paper then offers a commentary of legal alternatives to the current …

The Development Of Optical Sensing Techniques As Digital Tools To Predict The Sensory Quality Of Red Meat: A Review, Georgios Anagnostou, Alessandro Ferragina, Emily C. Crofton, Jesus Maria Frias Celayeta, Ruth M. Hamill

Research Outputs: 2025-Present

No abstract provided.

Motor Pool Selectivity Of Neuromuscular Degeneration In Type I Spinal Muscular Atrophy Is Conserved Between Human And Mouse, Justin C Lee, Wendy K Chung, David J Pisapia, Christopher E Henderson

Faculty, Staff and Students Publications

Spinal muscular atrophy (SMA) is caused by low levels of the survival motor neuron (SMN) protein. Even though SMN is ubiquitously expressed, the disease selectively affects motor neurons, leading to progressive muscle weakness. Even among motor neurons, certain motor units appear more clinically resistant to SMA. To quantitatively survey selective resistance, we studied extensive neuromuscular autopsies of Type I SMA patients and age-matched controls. We found highly divergent degrees of degeneration of neighboring motor units, even within individual cranial nerves or a single anatomical area such as the neck. Examination of a Type I SMA patient maintained on life support …

The Catch Effort Of Spiny Lobster (Panulirus Argus) On South Caicos, British West Indies, Edward J. Burge Jr

The Geographical Bulletin

The spiny lobster, Panulirus argus, which inhabits bank around South Caicos, Turks and Caicos Islands, is the most economically important crustacean in the Caribbean region. In recent years concern regarding overfishing has become prominent. In this study 46 boat loads of specimens, with catches derived from 11 fishing sites were surveyed for data sets including size, sex, and amount from each site. The catch-per-unit effort calculated for each site revealed that individual diving ability and ease of harvest were the greatest determinants for choice of fishing site. Environmental conditions of spiny lobster habitats; such as, water depth and direction of …

Temporal And Spatial Changes In Beaver Pond Locations, Eastern Glacier National Park, Montana, U.S.A., Ross K. Meentemeyer, David R. Butler

The Geographical Bulletin

Sequential aerial photographs from 1966, 1973, 1984, and 1991 were used to map the number and distribution of beaver ponds in a portion of eastern Glacier National Park, Montana. The most stable ponds were located on deltaic environments. Ponds located on intermittent streams were somewhat less stable. A general equilibrium of pond number and site location exists in the study area throughoutthe 25-year period. This result contrasts with those from historical studies in eastern and central North America, where beaver populations at the turn of the century had probably been much lower than in Glacier National Park.

Probing The Stability Of Designed Protein, Axel Irianni, Shuvo Chakraborty, Maral Afshinpour

SDSU Data Science Symposium

Naturally occurring proteins have evolved to perform specific biochemical functions, and their amino acid sequences are optimized for those functions rather than for stability. Enhancing protein stability without compromising its function is highly desirable for biotechnological applications, such as vaccine design. Computational protein design algorithms offer a solution by making targeted amino acid changes to the native protein sequence, potentially enhancing stability without the need for the lengthy, labor-intensive, and costly experimental processes typically involved in stabilizing proteins. There are various categories of computational protein design algorithms, and it remains unclear which approach is the most effective. In this study, …

Filters For Forecasting Crop Health: Analyzing And Projecting The Temporal Evolution Of Landsat Ndvi Data Using Dynamic Linear Models And The Kalman Filter, Kamal Albousafi, Hossein Moradi, Jung-Han Kimn

SDSU Data Science Symposium

Accurately forecasting food availability is a critical task. One approach involves utilizing remote sensing data, such as satellite images, to observe the health of crop fields using different Vegetation Indices (VI). The Normalized Difference Vegetation Index (NDVI) provides a sound metric to track the “greenness” of crops over time. In this research, we develop statistical models that capture the dynamics of NDVI time series data to make better predictions of its future values. The median NDVI of the pixels of a farm located in Edmunds County, South Dakota, is obtained using imagery from the Landsat 5 and Landsat 8 satellites, …