Digital Commons Network^™

The Shorthorn: October 10, 1921

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: October 03, 1921

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: January 1920

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: June, 1919

The Shorthorn Newspaper Collection: 1910s

No abstract provided.

Northern Red-Legged Frog Use Of A New Under-Road Crossing And Adjacent Upland Habitat, Alyson W. Yates, Catherine De Rivera

Urban Ecosystem Research Consortium of Portland/Vancouver

A population of northern red-legged frogs (Rana aurora) located in northwest Portland must make a perilous crossing over U.S. Hwy 30 to access their breeding habitat in the floodplain of the Willamette River. To address the significant frog mortality that has historically resulted from this seasonal crossing, the Oregon Department of Fish and Wildlife managed the installation of an under-road crossing structure, completed in October 2024. To date, no studies have documented the effectiveness of crossing structures installed for R. aurora use, and few studies have examined their effectiveness for amphibians after installation. To meet these needs, our research will …

Patterns In Human-Wildlife Conflict In The Portland Metro Area And Implications For Coexistence, Dave Keiter, Peter Iacono, Lindsey Sanders, Ben Cate

Urban Ecosystem Research Consortium of Portland/Vancouver

The Oregon Department of Fish and Wildlife (ODFW) is routinely contacted for technical advice and assistance in addressing real or perceived human-wildlife conflict across the state. Improved understanding of patterns of conflict between humans and wildlife in urban ecosystems can help to identify ways to reduce perceived conflict and guide targeted education and outreach campaigns to benefit human-wildlife coexistence in urban areas. We analyzed 2,874 reports of human conflict with wildlife received by ODFW wildlife biologists in the Portland metro area from 2022-2024. Our objectives were to 1) identify the wildlife species most frequently involved in real or perceived conflict …

Utilizing Roadkill Salvage To Bolster Chronic Wasting Disease Surveillance Data In Urban Areas, Steph Doorly, Trever B. Gelling

Urban Ecosystem Research Consortium of Portland/Vancouver

Chronic wasting disease (CWD) is a Transmissible Spongiform Encephalopathy that is always fatal to members of the deer family (Cervidae). CWD poses a unique challenge for wildlife managers as there is no cure or treatment for infected individuals, it remains transmissible and persistent in the environment, and symptoms become evident only after a long incubation period. The disease has yet to be detected in Oregon. CWD can impact trophic systems, economies, and sources of first foods. The Oregon Department of Fish and Wildlife’s (ODFW) CWD management plan includes increased surveillance through diversified sampling efforts, and public education and outreach. Monitoring …

Proceedings Of The 23rd Annual Urban Ecology & Conservation Symposium March 17, 2025, Urban Ecosystem Research Consortium Of Portland/Vancouver

Urban Ecosystem Research Consortium of Portland/Vancouver

These proceedings document the agenda and abstracts for presentations and posters from the 23rd annual conference organized by the Urban Ecosystem Research Consortium of Portland/Vancouver (UERC) which occurred on March 17, 2025. The UERC is a consortium of people from various universities and colleges, state and federal agencies, local governments, non-profit organizations and independent professionals interested in supporting urban ecosystem research and creating an information-sharing network of people that collect and use ecological data in the Portland/Vancouver area. The annual conference has an open call for abstracts. The UERC organizing committee selects the final oral and poster presentations, along with …

Comparative Soil Health In Urban Agrofrestry: A Case Study On Detroit's Perennial Agriculture Sites, Nia Dubon-Robinson

Urban Ecosystem Research Consortium of Portland/Vancouver

Urban ecosystems are being intentionally developed to enhance innovation and resilience, addressing various community needs. Urban agriculture, particularly, involves cultivating food on soils affected by industrial activities. Urban agroforestry serves as a strategy to generate ecosystem services while increasing the availability of regionally adapted fruit and nut trees. Unlike annual crop production, agroforestry initiatives require less extensive soil management and labor, which can in turn enhance soil health. This case study examines soil health indicators—physical (bulk density), chemical (soil organic matter fractions), and biological (microbial diversity)—in one young urban food forest compared to two older conventional urban orchards in Detroit, …

The Daily Gamecock: March 2025, University Of South Carolina, Office Of Student Media

2025

No abstract provided.

Sustainability Benefits Of Process Intensification With Advanced Single Use Technologies, Joris Van De Velde, Matthew Peters, Carolina Riba

Single Use Technologies VII: Revolutionizing Manufacturing for Tomorrow’s Medicines

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Flow-Through Ready For Use Technologies For A Continuous Downstream Process, Stuart Tindal, Alexandar Helling, Prateek Joshi, Martin Lobedann, Fabrizio Pelella, Lukas Kalbhenn, Martin Leuthold, Johannes Wortmeyer, Mark Brower, Lara Fernandez Cerezo, Adrian Gospodarek

Single Use Technologies VII: Revolutionizing Manufacturing for Tomorrow’s Medicines

Please click Additional Files below to see the full abstract

Technology Transfer And Scale-Up Of A High-Density E. Coli Fermentation From A 200 L Stainless Steel To A 1000 L Single-Use Fermenter, Cameron Graham, Rosane Rech

Single Use Technologies VII: Revolutionizing Manufacturing for Tomorrow’s Medicines

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Implementing X-Ray For Single-Use Systems Sterilization: What’S Next?, Samuel Dorey, Lucie Delaunay,, Nathalie Dupuy, Sylvain R. A Marque

Single Use Technologies VII: Revolutionizing Manufacturing for Tomorrow’s Medicines

Please click Additional Files below to see the full abstract

Enhancing Biocompatibility Of 3d Printed Polyurethane Parts Using Parylene Coating, Roberto Menzel, Dana Budde, Michael Zumbrum, Armin Hauk

Single Use Technologies VII: Revolutionizing Manufacturing for Tomorrow’s Medicines

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The Unified Phenotype Ontology : A Framework For Cross-Species Integrative Phenomics., Nicolas Matentzoglu, Susan M. Bello, Ray Stefancsik, Sarah M Alghamdi, Anna V Anagnostopoulos, James P Balhoff, Meghan A Balk, Yvonne M Bradford, Yasemin Bridges, Tiffany J Callahan, Harry Caufield, Alayne Cuzick, Leigh Carmody, Anita R Caron, Vinicius De Souza, Stacia R Engel, Petra Fey, Malcolm Fisher, Sarah Gehrke, Christian Grove, Peter Hansen, Nomi L Harris, Midori A Harris, Laura Harris, Arwa Ibrahim, Julius O B Jacobsen, Sebastian Köhler, Julie A Mcmurry, Violeta Munoz-Fuentes, Monica C Munoz-Torres, Helen Parkinson, Zoë M Pendlington, Clare Pilgrim, Sofia M C Robb, Peter N Robinson, James Seager, Erik Segerdell, Damian Smedley, Elliot Sollis, Sabrina Toro, Nicole Vasilevsky, Valerie Wood, Melissa A Haendel, Christopher J Mungall, James A Mclaughlin, David Osumi-Sutherland

Faculty Research 2025

Phenotypic data are critical for understanding biological mechanisms and consequences of genomic variation, and are pivotal for clinical use cases such as disease diagnostics and treatment development. For over a century, vast quantities of phenotype data have been collected in many different contexts covering a variety of organisms. The emerging field of phenomics focuses on integrating and interpreting these data to inform biological hypotheses. A major impediment in phenomics is the wide range of distinct and disconnected approaches to recording the observable characteristics of an organism. Phenotype data are collected and curated using free text, single terms or combinations of …

Faculty Senate Meeting Agenda And Minutes, March 17, 2025

Faculty Senate Minutes and Agendas

Agenda and minutes from the Wright State University Faculty Senate Meeting held on, March 17, 2025.

The Puzzle Of Biologics Manufacturing Platform Patents, Osmat Azzam Jeferson, W. Nicholson Price Ii, S. Sean Tu, Saurabh Vishnubhakat, Arti K. Rai

Articles

The predominance of manufacturing process patents asserted in litigation by originator biologics companies against would-be biosimilar entrants has resulted in a number of Congressional and administrative agency proposals that could increase scrutiny and limit enforceability.

Investigating Spatial Mapping Of Lipid And Protein Alterations Within Cells And Tissues Using Raman Microspectroscopy, Elnaz Sheikh

LSU Doctoral Dissertations

The progression of various diseases is associated with alterations in the microenvironment of cells, consisting of a variety of metabolites like lipids and proteins. It is well known that lipids and proteins are potential biomarkers for indicating alterations within the cell microenvironment induced by disease, and various methods are frequently used for their examination. To understand the chemical composition and spatial distribution of constituents in tissues and cells, confocal Raman spectroscopy and microscopy, as non-destructive tools, have shown potential for monitoring abnormalities at the cellular level with high resolution and can facilitate detection through targeting multiple biomarkers. The application of …

A Comparison Of Physical Characteristics In Different Brands And Staining Techniques In A Brand Of Lissamine Green Strips, Neema Ghorbani-Mojarrad, James S. Wolffsohn, Jennifer P. Craig, Debarun Dutta, Byki Huntjens, Raheel Hussain, Zarghona Khan, Shoaib Raja, Mohammed Ibrahim, Thomas Godfrey, Alison Alderson, Katharine Evans, Mahesh Joshi, Carole Maldonado-Codina, Manbir Nagra, Elidh Martin, Laura Sweeney, Louise Terry, Dean Dunning, Marta Vianya-Estopa

School of Health Professions

Backgrounds/Objectives: The aim of this study was to compare differences in the physical characteristics of lissamine green (LG) strips and the outcomes of using different staining techniques. Methods: Two separate complementary investigations were conducted. Physical study: Differences between four LG strips were evaluated in terms of material, dye concentration, and dye absorption. In vivo study: Bulbar conjunctival staining was compared for four application methods of I-DEW LG strips presented in a randomized order for twenty-two participants: (1) single application 5 s after wetting (also repeated using GreenGlo for comparison), (2) single application using two strips held together, 5 s after …

Bringing Parental Consent Out Of The Shadows: An Evaluation Of Texas H.B. 18'S Effect On A Child's Best Interest, Ainsley Mcnally

Texas A&M Law Review

Beyond constitutional assertions about broad parental rights lies the nuance of state laws affecting child autonomy. State laws take a variety of approaches to address the broad rights of parents to raise their children while acknowledging that these broad rights must give way in limited circumstances to promote the best interests of children. These differences under state law can be categorized into three approaches, including a bright-line, middle-ground, and extended autonomy approach. Naming and analyzing these approaches illuminates a new form of a bright-line approach—shadow parental consent—that Texas law has adopted. At first glance, the recently enacted Texas law, H.B. …

Independent- Mar. 17, 2025, Leslie Lozada

The Independent (1988-present)

No abstract provided.

Effects Of Exercise On Inflammation, Circulating Tumor Cells, And Circulating Tumor Dna In Colorectal Cancer, Justin C. Brown, Stephanie L. Compton, Andrew Kang, Anjana Jayaraman, L Anne Gilmore, Brian J. Kirby, Frank L. Greenway, Shengping Yang, Guillaume Spielmann

School of Medicine Faculty Publications

BACKGROUND: The biological mechanisms by which postdiagnosis physical activity improves disease-free survival in colorectal cancer survivors remain incompletely understood. This trial tested the hypothesis that 12 wk of moderate-intensity aerobic exercise, when compared with a control group, would change inflammation, CTCs, and ctDNA in a manner consistent with an improved cancer prognosis. METHODS: This trial randomized Stages I-III colorectal cancer survivors to 12 wk of home-based moderate-intensity aerobic exercise or a waitlist control group. The co-primary endpoints were high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6), secondary endpoints were soluble tumor necrosis factor-α receptor 2 (sTNFαR2) and circulating tumor cells (CTCs), …

Exploring Profiles Of Fathers Integrating Food And Physical Activity Parenting Practices, John A Jimenez-Garcia, Louise C Mâsse, Robert L Newton, Salma M Musaad, Alicia Beltran, Teresia M O'Connor

Children’s Nutrition Research Center Staff Publications

Objective: This study aims to identify fathers' profiles integrating food parenting practices (FPP) and physical activity parenting practices (PAPP).

Design: We analysed cross-sectional data. The fathers completed the reduced FPP and PAPP item banks and socio-demographic and family dynamics (co-parenting and household responsibility) questionnaires. We identified fathers' profiles via latent profile analysis. We explored the influence of social determinants, child characteristics and family dynamics on fathers' profiles using multinomial logistic regression.

Setting: Online survey in the USA.

Participants: Fathers of 5-11-year-old children.

Results: We analysed data from 606 fathers (age = 38 ± 8·0; Hispanic = 37·5 %). Most fathers …

Development Of S(Vi) And S(Iv) Chemistry: From Asymmetric Synthesis To Covalent Reactive Groups, Chuan Shan

USF Tampa Graduate Theses and Dissertations

This dissertation mainly covers the development of synthetic methodologies related to several heteroatom functional groups, including phosphonates P(V), sulfoximines S(VI), sulfonimidamides S(VI), sulfonimidoyl fluorides S(VI), and sulfinamides S(IV). The interests in these functionalities are not only out of chemistry curiosity but also due to their pharmaceutical importance indicated by the existing drug molecules that contain these functional groups. The first chapter introduced the importance of phosphonates in biochemistry and organic synthesis, also provided some essential background of our synthetic efforts. The second chapter described the phosphonate synthesis from commercially available starting materials, with the purpose to obtain heterocyclic phosphonates in …

Urban Beavers At The Crossroads: How Ecological Knowledge, Sociodemographic, And Spatial Context Shape Public Perception And Coexistence Preferences, Matthew Guziejka

Dissertations and Theses

Urban beavers demonstrate synurbization by adapting to urban environments, offering ecological benefits such as biodiversity enhancement and flood mitigation, while also occasionally conflicting with infrastructure. This study examines how ecological knowledge, sociodemographics, and spatial context influence public perceptions and management preferences for urban beavers in the Tualatin River watershed, Oregon.

A voluntary survey of 176 participants from peri-urban areas assessed demographic characteristics, ecological knowledge, and attitudes toward management approaches. Spatial factors, such as proximity to watercourses and green spaces, were also analyzed. Logistic regression analyses were used to explore relationships between these factors and management preferences. Political orientation was significantly …

Neural Correlates Of Opioid-Induced Risk-Taking Behavior In The Prelimbic Prefrontal Cortex, Cana B Quave, Andres M Vasquez, Guillermo Aquino-Miranda, Milagros Marín, Esha P Bora, Chinenye L Chidomere, Xu O Zhang, Douglas S Engelke, Fabricio H Do-Monte

Faculty, Staff and Student Publications

Opioid use disorder occurs alongside impaired risk-related decision-making, but the underlying neural correlates are unclear. We developed an approach-avoidance conflict task using a modified conditioned place preference procedure to study neural signals of risky opioid seeking in the prefrontal cortex, a region implicated in executive decision-making. Following morphine conditioned place preference, rats underwent a conflict test in which fear-inducing cat odor was introduced in the previously drug-paired side of the apparatus. While the saline-exposed control group avoided cat odor, the morphine group included two subsets of rats that either maintained a preference for the paired side despite the presence of …

An Exosome-Based Liquid Biopsy Predicts Depth Of Response And Survival Outcomes To Cetuximab And Panitumumab In Metastatic Colorectal Cancer: The Exonerate Study, Caiming Xu, Alessandro Mannucci, Francis Esposito, Helena Oliveres, Vicente Alonso-Orduña, Alfonso Yubero, Carlos Fernández-Martos, Antonieta Salud, Javier Gallego, Marta Martín-Richard, Julen Fernández-Plana, Mónica Guillot, Jorge Aparicio, Marwan Fakih, Scott Kopetz, Jaime Feliu, Joan Maurel, Ajay Goel

Faculty, Staff and Student Publications

Purpose: The EXOsome and cell-free miRNAs of anti-EGFR ResistAnce (EXONERATE) study was an open-label, biomarker interventional study designed to develop, test, and validate a liquid biopsy predictive of progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) for first-line EGFR inhibitors in metastatic colorectal cancer (mCRC).

Patients and methods: Patients with newly diagnosed RAS wild-type, chemotherapy-naïve mCRC, both right- and left-sided, were enrolled in two nationwide trials to receive cetuximab or panitumumab along with chemotherapy. The primary endpoint was 12-month PFS, which was hierarchically tested in left- and right-sided mCRCs to predict PFS, OS, and ORR.

Results: Genome-wide …

Ca-125 As A Biomarker In Renal Medullary Carcinoma: Integrated Molecular Profiling, Functional Characterization, And Prospective Clinical Validation, Sandra L Grimm, Menuka Karki, Kyle A Blum, Jean-Philippe Bertocchio, Rong He, Durga N Tripathi, Niki M Zacharias, Justin M Lebenthal, Rahul A Sheth, Priya Rao, Giannicola Genovese, Zhen Lu, Robert C Bast, Davis R Ingram, Rossana Lazcano, Khalida M Wani, Wei-Lien Wang, Alexander J Lazar, Nizar M Tannir, Cheryl L Walker, Cristian Coarfa, Pavlos Msaouel

Faculty, Staff and Student Publications

Purpose: Renal medullary carcinoma (RMC) is a highly aggressive malignancy defined by the loss of the SMARCB1 tumor suppressor. It mainly affects young individuals of African descent with sickle cell trait, and it is resistant to conventional therapies used for other renal cell carcinomas. This study aimed to identify potential biomarkers for early detection and disease monitoring of RMC.

Experimental design: Integrated profiling of primary untreated RMC tumor tissues and paired adjacent kidney controls was performed using RNA sequencing and histone chromatin immunoprecipitation sequencing. The expression of serum cancer antigen 125 (CA-125), was prospectively evaluated in 47 patients with RMC. …

Impact Of Co-Mutations And Transcriptional Signatures In Non-Small Cell Lung Cancer Patients Treated With Adagrasib In The Krystal-1 Trial, Marcelo V Negrao, Alvaro G Paula, David Molkentine, Laura Hover, Monique Nilsson, Natalie Vokes, Lars Engstrom, Andrew Calinisan, David M Briere, Laura Waters, Jill Hallin, Lixia Diao, Mehmet Altan, George R Blumenschein, Ferdinandos Skoulidis, Jing Wang, Scott E Kopetz, David S Hong, Don L Gibbons, Peter Olson, James G Christensen, John V Heymach

Faculty, Staff and Student Publications

Purpose: KRAS inhibitors are revolutionizing the treatment of non-small cell lung cancer (NSCLC), but clinico-genomic determinants of treatment efficacy warrant continued exploration.

Experimental design: Patients with advanced KRASG12C-mutant NSCLC treated with adagrasib [KRYSTAL-1 (NCT03785249)] were included in the analysis. Pretreatment next-generation sequencing data were collected per protocol. HTG EdgeSeq Transcriptome Panel was used for gene expression profiling. Clinical endpoints included objective response, progression-free survival (PFS), and overall survival (OS). KRASG12C-mutant NSCLC cell lines and xenograft models were used for sensitivity analyses and combination drug screens.

Results: KEAP1 MUT and STK11MUT were associated with shorter survival to adagrasib [KEAP1: …