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Bone Turnover Markers Response To Aerobic Versus Resistance Exercise Among Postmenopausal Saudi Women, Shehab Mahmoud Abd El-Kader, Shehab Mahmoud Abd E-Kader, Subhi Mustafa Neveen Refaey, Amany Gomaa Atiaa, Qawagzah Mar 2025

Bone Turnover Markers Response To Aerobic Versus Resistance Exercise Among Postmenopausal Saudi Women, Shehab Mahmoud Abd El-Kader, Shehab Mahmoud Abd E-Kader, Subhi Mustafa Neveen Refaey, Amany Gomaa Atiaa, Qawagzah

Journal of Medical Rehabilitation Science

Background: Menopause is characterized with low bone turnover biomarkers (BTMs) with faster reduction of bone mass and high fracture risk. Osteoporosis is considered as a major health related problem among Asian postmenopausal women. Physical exercise is an accepted modality in both primary and secondary prevention fracture related to osteoporosis. However, our understanding regarding the best exercise training program to prevent osteoporosis among postmenopausal women is incomplete.  Objective: The present study was designed to examine aerobic versus resisted exercise training effects upon postmenopausal Saudi women markers of bone turnover. Material and Methods: One hundred Saudi postmenopausal women, their age ranged from …


Intouch Week Of March 17, 2025, New York Medical College Mar 2025

The Prevalence Of Weapon Damage: A Proportional Meta-Analysis, Sarah Lane, Erin Mccullough Mar 2025

The Prevalence Of Weapon Damage: A Proportional Meta-Analysis, Sarah Lane, Erin Mccullough

School of Biological and Marine Sciences

Sexually selected weapons are tools that are used in physical fights over mating opportunities. Individuals can face dire fitness consequences if they break their weapon and can no longer fight effectively; however, the costs and consequences of weapon damage have largely been ignored. In this study, the literature was systematically searched to examine the prevalence of weapon damage, and a phylogenetically controlled proportional meta-analysis was conducted to explore factors influencing the patterns of weapon damage across the animal kingdom. A total of 36 suitable studies were identified across 74 species and 13 orders for a total of 82 effect sizes. …


Identification Of Lysosomal Lipolysis As An Essential Noncanonical Mediator Of Adipocyte Fasting And Cold-Induced Lipolysis, Yu-Sheng Yeh, Trent D. Evans, Mari Iwase, Se-Jin Jeong, Arick Park, Ali Ghasemian, Borna Dianati, Ali Javaheri, Et Al. Mar 2025

Identification Of Lysosomal Lipolysis As An Essential Noncanonical Mediator Of Adipocyte Fasting And Cold-Induced Lipolysis, Yu-Sheng Yeh, Trent D. Evans, Mari Iwase, Se-Jin Jeong, Arick Park, Ali Ghasemian, Borna Dianati, Ali Javaheri, Et Al.

2020-Current year OA Pubs

Adipose tissue lipolysis is the process by which triglycerides in lipid stores are hydrolyzed into free fatty acids (FFAs), serving as fuel during fasting or cold-induced thermogenesis. Although cytosolic lipases are considered the predominant mechanism of liberating FFAs, lipolysis also occurs in lysosomes via lysosomal acid lipase (LIPA), albeit with unclear roles in lipid storage and whole-body metabolism. We found that adipocyte LIPA expression increased in adipose tissue of mice when lipolysis was stimulated during fasting, cold exposure, or β-adrenergic agonism. This was functionally important, as inhibition of LIPA genetically or pharmacologically resulted in lower plasma FFAs under lipolytic conditions. …


Antioxidant And Chemotherapeutic Synergy: Triphala Enhances Doxorubicin Cytotoxicity In Breast Cancer Cells And Reduces Toxicity In Non-Tumorigenic Cells, Supamas Charucharana, Poonlarp Cheepsunthorn Ph.D., Chalisa Louicharoen Cheepsunthorn Ph.D. Mar 2025

Antioxidant And Chemotherapeutic Synergy: Triphala Enhances Doxorubicin Cytotoxicity In Breast Cancer Cells And Reduces Toxicity In Non-Tumorigenic Cells, Supamas Charucharana, Poonlarp Cheepsunthorn Ph.D., Chalisa Louicharoen Cheepsunthorn Ph.D.

Chulalongkorn Medical Journal

Background: The combining of antioxidants with chemotherapy is increasingly explored to minimize toxicity in non-cancerous cells during breast cancer treatment. Triphala (TPL), a Thai herbal compound rich in antioxidants, shows potential as a complementary candidate for breast cancer chemotherapy.

Objective: This study investigated the combined effects of TPL and low-dose doxorubicin (DOX) on human breast cancer and non-tumorigenic mammary epithelial cells.

Methods: TPL’s bioactive compounds were analyzed via high-performance liquid chromatography (HPLC). Cell viability and reactive oxygen species (ROS) levels were assessed in breast cancer (MDA-MB-231, MCF-7) and epithelial (MCF-10A) cells using thiazolyl blue tetrazolium bromide (MTT) and chloromethyl 2′,7′-dichlorodihydrofluorescein …


Blood Tnf-Α And Gabra-1 Levels In Individuals With Poor Ovarian Response Underwent In Vitro Fertilization Program, Gadsara Ruangprachum, Paweena Thuwanut, Wisan Sereepapong, Vorasuk Shotelersuk, Siraprapa Tongkobpetch, Porntip Sirayapiwat Mar 2025

Blood Tnf-Α And Gabra-1 Levels In Individuals With Poor Ovarian Response Underwent In Vitro Fertilization Program, Gadsara Ruangprachum, Paweena Thuwanut, Wisan Sereepapong, Vorasuk Shotelersuk, Siraprapa Tongkobpetch, Porntip Sirayapiwat

Chulalongkorn Medical Journal

Background: Poor ovarian response (POR) to ovarian stimulation during in vitro fertilization (IVF) program remains a critical issue contributing to decreased ovarian reserve and cancellation of IVF cycles. Nevertheless, the complete etiology of PRO condition remains inadequately understood.

Objectives: This research primarily aimed to compare levels of blood pro-inflammatory cytokine (TNF-α) and apoptotic marker (GABRA-1) between those exhibiting normal ovarian response (NOR) and those with poor ovarian response during IVF program.

Methods: A cross-sectional study involving whole blood collection from 25 participants was conducted (15 individuals in NOR group and 10 in POR group). Relative gene expression levels of blood …


Exploring The Therapeutic Potential Of Trigonella Foenum-Graecum Extract-Loaded Transferosomal Gel In Freund's Complete Adjuvant-Induced Rat Models., Vandana Singh Ms., Hema Arya Ms., Bhavana Singh Dr., Koushal Dhamija Mr., Preeti Singh Dr., Gautam Kumar Dr. Mar 2025

Exploring The Therapeutic Potential Of Trigonella Foenum-Graecum Extract-Loaded Transferosomal Gel In Freund's Complete Adjuvant-Induced Rat Models., Vandana Singh Ms., Hema Arya Ms., Bhavana Singh Dr., Koushal Dhamija Mr., Preeti Singh Dr., Gautam Kumar Dr.

Chulalongkorn Medical Journal

Abstract:

Background: Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by inflammation and joint damage.

Objective: This study aimed to evaluate the antiarthritic activity of Trigonella foenum-graecum (TFG) Transferosomal gel in a Freund’s adjuvant-induced arthritic rat model and compare it with Diclofenac gel, a standard anti-inflammatory drug.

Methods: Arthritis was induced in rats by injecting a 0.1 mL (1mg/ml) CFA suspension into the left hind foot in the subplantar region, allowing them to develop arthritis for 21 days.

Results: Arthritis induction led to a significant increase in paw volume, indicative of inflammation. Treatment with both TFG-transferosomal gel and Diclofenac …


Cracking The Code Of Hbv Persistence: Cutting-Edge Approaches To Targeting Cccdna In Chronic Hepatitis B With Or Without Pyogenic Liver Abscesses, Umar Saeed, Zahra Zahid Piracha, Mahmood Khan, Muhammad Nouman Tariq, Syed Shahan Gilani, Muhammad Raza, Rakshana Munuswamy, Naveen Bose, Dilber Uzun Ozsahin, Ilker Özşahin, Surya M. Nauli Mar 2025

Cracking The Code Of Hbv Persistence: Cutting-Edge Approaches To Targeting Cccdna In Chronic Hepatitis B With Or Without Pyogenic Liver Abscesses, Umar Saeed, Zahra Zahid Piracha, Mahmood Khan, Muhammad Nouman Tariq, Syed Shahan Gilani, Muhammad Raza, Rakshana Munuswamy, Naveen Bose, Dilber Uzun Ozsahin, Ilker Özşahin, Surya M. Nauli

Pharmacy Faculty Articles and Research

Chronic Hepatitis B Virus (HBV) infection remains a formidable global health challenge, driving severe liver complications such as hepatocellular carcinoma (HCC) and pyogenic liver abscesses (PLA). At the core of HBV persistence lies covalently closed circular DNA (cccDNA), a viral reservoir that fuels ongoing infection despite antiviral treatments. This review highlights molecular mechanisms governing cccDNA formation, maintenance, and clearance, spotlighting innovative therapeutic strategies to disrupt this key viral element. We explore cutting-edge approaches, including epigenetic modulation to silence cccDNA, RNA interference (RNAi) for viral RNA degradation, and CRISPR/Cas genome editing to excise cccDNA directly. Additionally, emerging antiviral therapies and immunotherapies, …


Small Molecule B-Raf Inhibitors As Anti-Cancer Therapeutics: Advances In Discovery, Development, And Mechanistic Insights, Yamile Abuchard Anaya, Ricardo Pequeno Bracho, Subhash Chauhan, Manish K. Tripathi, Debasish Bandyopadhyay Mar 2025

Small Molecule B-Raf Inhibitors As Anti-Cancer Therapeutics: Advances In Discovery, Development, And Mechanistic Insights, Yamile Abuchard Anaya, Ricardo Pequeno Bracho, Subhash Chauhan, Manish K. Tripathi, Debasish Bandyopadhyay

School of Medicine Publications

B-RAF is a serine/threonine kinase that plays a crucial role in the MAPK signaling pathway, regulating cell proliferation and survival. Mutations in B-RAF, particularly V600E, are associated with several malignancies, including melanoma, colorectal cancer, and non-small cell lung cancer, making it a key therapeutic target. The development of B-RAF inhibitors, such as Vemurafenib, Dabrafenib, and second-generation inhibitors like Encorafenib, has led to significant advancements in targeted cancer therapy. However, acquired resistance, driven by MAPK pathway reactivation, RAF dimerization, and alternative signaling pathways, remains a major challenge. This review explores the molecular mechanisms of B-RAF inhibitors, their therapeutic efficacy, and resistance …


Color Aberrations In Seven Bird Species In Costa Rica, Lucia Isabel Lopez, Jose Manuel Mora, Adrian Alvarado Rivera Mar 2025

Color Aberrations In Seven Bird Species In Costa Rica, Lucia Isabel Lopez, Jose Manuel Mora, Adrian Alvarado Rivera

Biology Faculty Publications and Presentations

Although there are 935 species of birds in Costa Rica, scientific reports of pigmentation abnormalities in this group are limited. Nevertheless, several cases have been recently documented, including Leucism, Ino mutation, Progressive Graying, Dilution, and two unusual color aberrations in a toucan and a motmot. Here we describe seven cases of color aberrations observed over a period of five years in native birds of Costa Rica. An Eastern Wood-Pewee Contopus virens and a White-collared Manakin manacus candei were Brown. A Scintillant Hummingbird Selasphorus scintilla and a Talamanca Hummingbird, Eugenes spectabilis, also showed a Brown mutation, however, these two cases may …


Books And Media Mar 2025

Books And Media

Appalachia

Reviews of: A Light Through the Cracks: A Climber's Story, by Beth Rodden; Blood Sweat Tears, edited by Christine Reed; Pack Light: A Journey to Find Myself, by Shilletha Curtis; Alpine Rising: Sherpas, Baltis, and the Triumph of Local Climbers in the Greater Ranges, by Bernadette McDonald; Headstrap: Legends and Lore From the Climbing Sherpas of Darjeeling, by Nandini Purandare and Deepa Balsavar; Tramping Monadnock! New Discoveries with Henry David Thoreau, by Robert M. Young; Ghosts of Glencoe, by Chuck Schwerin; The Lifer: Rock Climbing Adventures in the Gunks and Beyond, by …


Waterman Fund Essay Winner: Old Friends In The Alpine: Field Scientists On Vermont's Highest Peak, Catherine Wessel Mar 2025

Waterman Fund Essay Winner: Old Friends In The Alpine: Field Scientists On Vermont's Highest Peak, Catherine Wessel

Appalachia

In this winning essay of the annual contest sponsored by the Waterman Fund, a young scientist meets Bill Howland, who studied the same vegetation in 1991, at their study site high on Vermont’s Mount Mansfield.


Fighting Instinct: The Brain, Emotions And Decision-Making In The Water, Jill Nash, Sam Hills Mar 2025

Fighting Instinct: The Brain, Emotions And Decision-Making In The Water, Jill Nash, Sam Hills

International Journal of Aquatic Research and Education

This conceptual paper explores the complex interplay among the human brain, emotions, and decision-making processes, particularly in aquatic environments. Integrating insights from neuroscience, psychology, and behavioural economics, we investigate how instinctual responses and emotional states influence our decisions during water-related activities. By analysing both biological and psychological factors, the paper aims to illuminate the intricacies of human behaviour in various aquatic settings and highlights significant gaps in the research on emotional decision-making that warrant further investigation. Additionally, the paper suggests interventions, including plausible communication strategies, to mitigate the impact of instinctual responses and improve safety and decision-making efficiency.


Microfluidic Blood-Milk Barrier And Physiologically Based Pharmacokinetic Model To Predict Lofexidine Secretion Into Breast Milk, Sanat Kumar Dash, Mohammad Asikur Rahman, Bofang Yi, Brianna Williams, Gi S. Lim, Sindi Zhou, Peng Zou, Yanyan Li, Gretchen J. Mahler, Tao Zhang Mar 2025

Microfluidic Blood-Milk Barrier And Physiologically Based Pharmacokinetic Model To Predict Lofexidine Secretion Into Breast Milk, Sanat Kumar Dash, Mohammad Asikur Rahman, Bofang Yi, Brianna Williams, Gi S. Lim, Sindi Zhou, Peng Zou, Yanyan Li, Gretchen J. Mahler, Tao Zhang

Pharmacy Faculty Scholarship

Introduction: Lofexidine (LUCEMYRA ®) is the only FDA-approved, non-opioid, non-addictive treatment for opioid withdrawal symptoms, crucial for postpartum and pregnant women affected by the opioid crisis. Despite its clinical importance, data on its secretion into breast milk is limited. This study aims to develop a novel, microfluidic-based blood-milk-barrier on a chip model, a static human mammary cell transwell model, and a physiologically based pharmacokinetic (PBPK) lactation model to estimate the breast milk secretion of lofexidine, thereby ensuring maternal and infant safety and improving withdrawal management. Methods: A novel microfluidic device was developed to build a mammary epithelium-on-a-chip model, and a …


Forb Diversity Globally Is Harmed By Nutrient Enrichment But Can Be Rescued By Large Mammalian Herbivory, Rebecca A. Nelson, Lauren L. Sullivan, Erika I. Hersch-Green, Eric W. Seabloom, Elizabeth T. Borer, Pedro M. Tognetti, Peter B. Adler, Lori Biederman, Miguel N. Bugalho, Maria C. Caldeira, Juan P. Cancela, Luísa G. Carvalheiro, Jane A. Catford, Chris R. Dickman, Aleksandra J. Dolezal, Ian Donohue, Anne Ebeling, Nico Eisenhauer, Kenneth J. Elgersma, Anu Eskelinen, Catalina Estrada, Magda Garbowski, Pamela Graff, Daniel S. Gruner, Nicole Hagenah, Sylvia Haider, W. Stanley Harpole, Yann Hautier, Anke Jentsch, Nicolina Johanson, Sally E. Koerner, Lucíola S. Lannes, Andrew S. Macdougall, Holly Martinson, John W. Morgan, Harry Olde Venterink, Devyn Orr, Brooke B. Osborne, Pablo L. Peri, Sally A. Power, Xavier Raynaud, Anita C. Risch, Mani Shrestha, Nicholas G. Smith, Carly J. Stevens, G. F. Ciska Veen, Risto Virtanen, Glenda M. Wardle, Amelia A. Wolf, Alyssa L. Young, Susan P. Harrison Mar 2025

Forb Diversity Globally Is Harmed By Nutrient Enrichment But Can Be Rescued By Large Mammalian Herbivory, Rebecca A. Nelson, Lauren L. Sullivan, Erika I. Hersch-Green, Eric W. Seabloom, Elizabeth T. Borer, Pedro M. Tognetti, Peter B. Adler, Lori Biederman, Miguel N. Bugalho, Maria C. Caldeira, Juan P. Cancela, Luísa G. Carvalheiro, Jane A. Catford, Chris R. Dickman, Aleksandra J. Dolezal, Ian Donohue, Anne Ebeling, Nico Eisenhauer, Kenneth J. Elgersma, Anu Eskelinen, Catalina Estrada, Magda Garbowski, Pamela Graff, Daniel S. Gruner, Nicole Hagenah, Sylvia Haider, W. Stanley Harpole, Yann Hautier, Anke Jentsch, Nicolina Johanson, Sally E. Koerner, Lucíola S. Lannes, Andrew S. Macdougall, Holly Martinson, John W. Morgan, Harry Olde Venterink, Devyn Orr, Brooke B. Osborne, Pablo L. Peri, Sally A. Power, Xavier Raynaud, Anita C. Risch, Mani Shrestha, Nicholas G. Smith, Carly J. Stevens, G. F. Ciska Veen, Risto Virtanen, Glenda M. Wardle, Amelia A. Wolf, Alyssa L. Young, Susan P. Harrison

Wildland Resources Faculty Publications

Forbs (“wildflowers”) are important contributors to grassland biodiversity but are vulnerable to environmental changes. In a factorial experiment at 94 sites on 6 continents, we test the global generality of several broad predictions: (1) Forb cover and richness decline under nutrient enrichment, particularly nitrogen enrichment. (2) Forb cover and richness increase under herbivory by large mammals. (3) Forb richness and cover are less affected by nutrient enrichment and herbivory in more arid climates, because water limitation reduces the impacts of competition with grasses. (4) Forb families will respond differently to nutrient enrichment and mammalian herbivory due to differences in nutrient …


Physics Alumni Newsletter Spring 2025, Terry Goforth Mar 2025

Physics Alumni Newsletter Spring 2025, Terry Goforth

Physics Alumni Newsletter

Physics Alumni Newsletter

The Physics Alumni Newsletter is produced by the SWOSU Physics Department.

Our Engineering Physics students are recruited in fields such as electronics, aerospace, mechanical engineering, petroleum engineering and software engineering. Graduates also have careers in meteorology, architecture, education and more.


A Satellite Cell-Dependent Epigenetic Fingerprint In Skeletal Muscle Identity Genes After Lifelong Physical Activity, Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan, Hunter L. Porter, Jonathan D. Wren, Willard M. Freeman, Esther E. Dupont-Versteegden, Yuan Wen Mar 2025

A Satellite Cell-Dependent Epigenetic Fingerprint In Skeletal Muscle Identity Genes After Lifelong Physical Activity, Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan, Hunter L. Porter, Jonathan D. Wren, Willard M. Freeman, Esther E. Dupont-Versteegden, Yuan Wen

Physiology Faculty Publications

Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The mechanisms by which satellite cells mediate skeletal muscle responsiveness to physical activity throughout the lifespan are still being defined, but epigenetic regulation may play a role. To explore this possibility, we analyzed global DNA methylation patterns in muscle tissue from female mice that engaged in lifelong voluntary unweighted wheel running with or without satellite cells. Satellite cells were ablated in adulthood using the tamoxifen-inducible Pax7-DTA model. Compared to sedentary …


Forb Diversity Globally Is Harmed By Nutrient Enrichment But Can Be Rescued By Large Mammalian Herbivory, Rebecca A. Nelson, Lauren L. Sullivan, Erika I. Hersch-Green, Eric W. Seabloom, Elizabeth T. Borer, Pedro M. Tognetti, Peter B. Adler, Lori Biederman, Miguel N. Bugalho, Maria C. Caldeira, Juan P. Cancela, Kenneth J. Elgersma Mar 2025

Forb Diversity Globally Is Harmed By Nutrient Enrichment But Can Be Rescued By Large Mammalian Herbivory, Rebecca A. Nelson, Lauren L. Sullivan, Erika I. Hersch-Green, Eric W. Seabloom, Elizabeth T. Borer, Pedro M. Tognetti, Peter B. Adler, Lori Biederman, Miguel N. Bugalho, Maria C. Caldeira, Juan P. Cancela, Kenneth J. Elgersma

Faculty Publications

Forbs (“wildflowers”) are important contributors to grassland biodiversity but are vulnerable to environmental changes. In a factorial experiment at 94 sites on 6 continents, we test the global generality of several broad predictions: (1) Forb cover and richness decline under nutrient enrichment, particularly nitrogen enrichment. (2) Forb cover and richness increase under herbivory by large mammals. (3) Forb richness and cover are less affected by nutrient enrichment and herbivory in more arid climates, because water limitation reduces the impacts of competition with grasses. (4) Forb families will respond differently to nutrient enrichment and mammalian herbivory due to differences in nutrient …


Removal Of Per- And Polyfluoroalkyl Substances Using Commercially Available Sorbents, Zhiming Zhang, Sevda Joudiazar, Anshuman Satpathy, Eustace Fernando, Roxana Rahmati, Rupali Datta, Et. Al. Mar 2025

Removal Of Per- And Polyfluoroalkyl Substances Using Commercially Available Sorbents, Zhiming Zhang, Sevda Joudiazar, Anshuman Satpathy, Eustace Fernando, Roxana Rahmati, Rupali Datta, Et. Al.

Michigan Tech Publications

Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants of growing environmental and human health concern, widely detected across various environmental compartments. Effective remediation strategies are essential to mitigate their widespread impacts. This study compared the performance of two types of commercially available sorbent materials, granular activated carbon (GAC, Filtrasorb-400) and organoclays (OC-200, and modified organoclays Fluoro-sorb-100 and Fluoro-sorb-200) for the removal of three representative PFAS compounds: perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorooctane sulfonic acid (PFOS) from water. Both organoclays and modified organoclays outperformed GAC, likely due to electrostatic interactions between the anionic PFAS compounds and the cationic …


Forb Diversity Globally Is Harmed By Nutrient Enrichment But Can Be Rescued By Large Mammalian Herbivory, Rebecca A. Nelson, Lauren L. Sullivan, Erika Hersch-Green, Eric W. Seabloom, Elizabeth T. Borer, Pedro M. Tognetti, Et Al. Mar 2025

Forb Diversity Globally Is Harmed By Nutrient Enrichment But Can Be Rescued By Large Mammalian Herbivory, Rebecca A. Nelson, Lauren L. Sullivan, Erika Hersch-Green, Eric W. Seabloom, Elizabeth T. Borer, Pedro M. Tognetti, Et Al.

Michigan Tech Publications

Forbs (“wildflowers”) are important contributors to grassland biodiversity but are vulnerable to environmental changes. In a factorial experiment at 94 sites on 6 continents, we test the global generality of several broad predictions: (1) Forb cover and richness decline under nutrient enrichment, particularly nitrogen enrichment. (2) Forb cover and richness increase under herbivory by large mammals. (3) Forb richness and cover are less affected by nutrient enrichment and herbivory in more arid climates, because water limitation reduces the impacts of competition with grasses. (4) Forb families will respond differently to nutrient enrichment and mammalian herbivory due to differences in nutrient …


Effect Of Testosterone Treatment During Puberty In Boys With Klinefelter Syndrome (The Tipy Study): Protocol For A Nationwide Randomised, Double-Blinded, Placebo-Controlled Study, Ida Dyhr Caspersen, Andrés Felipe Østergaard Fritzbøger, Jørgen Holm Petersen, Niels Birkebæk, Ann-Margrethe Rønholt Christensen, Anders Jørgen Schou, Kurt Kristensen, Judith L. Ross, Shanlee Davis, Gary Butler, Sophie Van Rijn, Anders Juul, Lise Aksglaede Mar 2025

Effect Of Testosterone Treatment During Puberty In Boys With Klinefelter Syndrome (The Tipy Study): Protocol For A Nationwide Randomised, Double-Blinded, Placebo-Controlled Study, Ida Dyhr Caspersen, Andrés Felipe Østergaard Fritzbøger, Jørgen Holm Petersen, Niels Birkebæk, Ann-Margrethe Rønholt Christensen, Anders Jørgen Schou, Kurt Kristensen, Judith L. Ross, Shanlee Davis, Gary Butler, Sophie Van Rijn, Anders Juul, Lise Aksglaede

Department of Pediatrics Faculty Papers

INTRODUCTION: Klinefelter syndrome (KS) is a genetic condition characterised by the presence of an extra X chromosome in males (47,XXY). KS is associated with various phenotypic characteristics in adult life, including infertility, hypogonadism and increased risk of type II diabetes, cardiovascular disease and osteoporosis. Additionally, individuals with KS often experience mental health challenges and functional impairments that significantly impact their quality of life. Currently, testosterone replacement therapy (TRT) in adolescence is considered the first-line treatment by some physicians for patients with KS and biochemical signs of hypogonadism. However, comprehensive evidence on its effectiveness in preventing typical phenotypic traits associated with …


Respiratory Muscle Strength Training For Persistent Dyspnea In Individuals With Post-Covid-19, Sandra P. Morgan Mar 2025

Respiratory Muscle Strength Training For Persistent Dyspnea In Individuals With Post-Covid-19, Sandra P. Morgan

USF Tampa Graduate Theses and Dissertations

Severe acute respiratory syndrome 2 coronavirus has resulted in more than 775 million known cases and greater than seven million deaths globally. Up to 25% of patients experience ongoing symptoms three months after the acute illness, and up to 30% of these individuals report persistent dyspnea. The overall aims of this dissertation are to 1) examine the risk factors and predictors for developing persistent dyspnea, 2) measure the effects of respiratory muscle strength training on dyspnea, pulmonary symptoms, quality of life, pulmonary function, and functional capacity, and 3) compare the outcomes of two different respiratory muscle strength training interventions.

In …


Investigation Of Dynamic Regulation Of Tfeb Nuclear Shuttling By Microfluidics And Quantitative Modelling, Iacopo Ruolo, Sara Napolitano, Lorena Postiglione, Gennaro Napolitano, Andrea Ballabio, Diego Di Bernardo Mar 2025

Investigation Of Dynamic Regulation Of Tfeb Nuclear Shuttling By Microfluidics And Quantitative Modelling, Iacopo Ruolo, Sara Napolitano, Lorena Postiglione, Gennaro Napolitano, Andrea Ballabio, Diego Di Bernardo

Duncan NRI Faculty and Staff Publications

Transcription Factor EB (TFEB) controls lysosomal biogenesis and autophagy in response to nutritional status and other stress factors. Although its regulation by nuclear translocation is known to involve a complex network of well-studied regulatory processes, the precise contribution of each of these mechanisms is unclear. Using microfluidics technology and real-time imaging coupled with mathematical modelling, we explored the dynamic regulation of TFEB under different conditions. We found that TFEB nuclear translocation upon nutrient deprivation happens in two phases: a fast one characterised by a transient boost in TFEB dephosphorylation dependent on transient calcium release mediated by mucolipin 1 (MCOLN1) followed …


Inflammation And Gut Barrier Function-Related Genes And Colorectal Cancer Risk In Western European Populations, Hannah B Mandle, Mazda Jenab, Marc J Gunter, Anne Tjønneland, Anja Olsen, Christina C Dahm, Jie Zhang, Pierre-Emmanuel Sugier, Joseph Rothwell, Gianluca Severi, Rudolf Kaaks, Verena A Katzke, Matthias B Schulze, Giovanna Masala, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Catalina Bonet, Maria-Jose Sánchez, Pilar Amiano, José María Huerta, Marcela Guevara, Richard Palmqvist, Thyra Löwenmark, Aurora Perez-Cornago, Elisabete Weiderpass, Alicia K Heath, Amanda J Cross, Paolo Vineis, David J Hughes, Veronika Fedirko Mar 2025

Inflammation And Gut Barrier Function-Related Genes And Colorectal Cancer Risk In Western European Populations, Hannah B Mandle, Mazda Jenab, Marc J Gunter, Anne Tjønneland, Anja Olsen, Christina C Dahm, Jie Zhang, Pierre-Emmanuel Sugier, Joseph Rothwell, Gianluca Severi, Rudolf Kaaks, Verena A Katzke, Matthias B Schulze, Giovanna Masala, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Catalina Bonet, Maria-Jose Sánchez, Pilar Amiano, José María Huerta, Marcela Guevara, Richard Palmqvist, Thyra Löwenmark, Aurora Perez-Cornago, Elisabete Weiderpass, Alicia K Heath, Amanda J Cross, Paolo Vineis, David J Hughes, Veronika Fedirko

Faculty, Staff and Student Publications

Gut barrier dysfunction and related inflammation are known to be associated with the development and progression of colorectal cancer (CRC). We investigated associations of 292 single-nucleotide polymorphisms (SNPs) from 27 genes related to endotoxins/lipopolysaccharide (LPS) sensing and tolerance, mucin synthesis, inflammation, and Crohn's disease with colon and rectal cancer risks. Incident CRC cases (N = 1374; colon = 871, rectum = 503) were matched 1:1 to controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. Previously measured serum concentrations of gut barrier function and inflammation biomarkers (flagellin/LPS-specific immunoglobulins and C-reactive protein [CRP]) were available for a sub-set …


Adding Metastasis-Directed Therapy To Standard-Of-Care Systemic Therapy For Oligometastatic Breast Cancer (Extend): A Multicenter, Randomized Phase 2 Trial, Jay P Reddy, Alexander D Sherry, Bryan Fellman, Suyu Liu, Tharakeswara Bathala, Cara Haymaker, Lorenzo Cohen, Benjamin D Smith, David Ramirez, Simona F Shaitelman, Stephen G Chun, Marina Medina-Rosales, Mediget Teshome, Abenaa Brewster, Carlos H Barcenas, Alexandre Reuben, Amol J Ghia, Ethan B Ludmir, Daniel Weed, Shalin J Shah, Melissa P Mitchell, Wendy A Woodward, Daniel R Gomez, Chad Tang Mar 2025

Adding Metastasis-Directed Therapy To Standard-Of-Care Systemic Therapy For Oligometastatic Breast Cancer (Extend): A Multicenter, Randomized Phase 2 Trial, Jay P Reddy, Alexander D Sherry, Bryan Fellman, Suyu Liu, Tharakeswara Bathala, Cara Haymaker, Lorenzo Cohen, Benjamin D Smith, David Ramirez, Simona F Shaitelman, Stephen G Chun, Marina Medina-Rosales, Mediget Teshome, Abenaa Brewster, Carlos H Barcenas, Alexandre Reuben, Amol J Ghia, Ethan B Ludmir, Daniel Weed, Shalin J Shah, Melissa P Mitchell, Wendy A Woodward, Daniel R Gomez, Chad Tang

Faculty, Staff and Student Publications

PURPOSE: Prior evidence suggests a progression-free survival (PFS) benefit from adding metastasis-directed therapy (MDT) to standard-of-care (SOC) systemic therapy for patients with some oligometastatic solid tumors. Randomized trials testing this hypothesis in breast cancer have yet to be published. We sought to determine whether adding MDT to SOC systemic therapy improves PFS in oligometastatic breast cancer.

METHODS AND MATERIALS: External Beam Radiation to Eliminate Nominal Metastatic Disease is a multicenter phase 2 randomized basket trial testing the addition of MDT to SOC systemic therapy in patients with ≤5 metastases (NCT03599765). Patients were randomly assigned 1:1 to MDT (definitive local treatment …


Extensive Epigenomic Dysregulation Is A Hallmark Of Homologous Recombination Deficiency In Triple-Negative Breast Cancer, Youdinghuan Chen, Lucas A Salas, Jonathan D Marotti, Nicole P Jenkins, Chao Cheng, Todd W Miller, Arminja N Kettenbach, Brock C Christensen Mar 2025

Extensive Epigenomic Dysregulation Is A Hallmark Of Homologous Recombination Deficiency In Triple-Negative Breast Cancer, Youdinghuan Chen, Lucas A Salas, Jonathan D Marotti, Nicole P Jenkins, Chao Cheng, Todd W Miller, Arminja N Kettenbach, Brock C Christensen

Faculty, Staff and Students Publications

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with substantial disease heterogeneity, limited treatment options, and dismal clinical outcomes. Some TNBCs display homologous recombination deficiency (HRD), a phenotype with elevated genomic burden and worse prognosis if left untreated but chemotherapeutic sensitivity. While the molecular landscape of TNBC is distinct from other breast cancer subtypes, the TNBC-specific link between HRD and epigenome-wide methylation has not been established. This study reports two independent cohorts of TNBC tumors (n = 32 and n = 58) with HRD and epigenomic landscapes measured by the Multiplex Ligation-dependent Probe Amplification assay and the …


Your Higher Self (Le Plein Potentiel), Dereck Daschke Mar 2025

Your Higher Self (Le Plein Potentiel), Dereck Daschke

Journal of Religion & Film

This is a film review of Your Higher Self (Le Plein Potentiel) (2025) directed by Annie St-Pierre.


The Few-Nexus: Using Soil To Grow Meaning And Relevance In Undergraduate General Education Earth Science Courses, Katherine Mccarville Mar 2025

The Few-Nexus: Using Soil To Grow Meaning And Relevance In Undergraduate General Education Earth Science Courses, Katherine Mccarville

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

Soils are central to human survival, through their critical roles in regulating water supplies and providing the medium for most agricultural productivity. Even as fewer and fewer students know where their water and food come from, and where their wastes go, soils tend to be under-emphasized in Earth science general education courses. Combining a place-based focus on soils with the FEW-Nexus model provides an integrating context for concepts and information that students sometimes perceive as disconnected and irrelevant to them. This approach can transform the experiences and learning of undergraduate students in the Earth science general education curriculum.


Cyanobacteria And Algae From Chýnov And Koněprusy Caves (Czech Republic), Michaela Wipplingerová, Jan Pokorný, Jan Kaštovský Mar 2025

Cyanobacteria And Algae From Chýnov And Koněprusy Caves (Czech Republic), Michaela Wipplingerová, Jan Pokorný, Jan Kaštovský

International Journal of Speleology

Algae and cyanobacteria have been studied in two so far phycologically unexplored show caves (Chýnov and Koněprusy) in the Czech Republic. Taxa were identified morphologically using cultivation and subsequent light microscopy, while problematic cyanobacterial species were verified by sequencing the genes for 16S rRNA and 16S–23S internal transcribed spacer. A total of 13 cyanobacterial taxa were found, two Bacillariophyceae, three Xanthophyceae, four Chlorophyceae, six Trebouxiophyceae, 11 Streptophyta, and three Euglenida; many of these species were found for the first time in the caves. The darker parts of the caves were dominated by cyanobacteria, and green algae were found predominantly right …


Being The Beloved: Cultivating A Head To Heart Journey Of Identity For Emerging Adults In Ministry And Leadership, Jennifer Clark Mar 2025

Being The Beloved: Cultivating A Head To Heart Journey Of Identity For Emerging Adults In Ministry And Leadership, Jennifer Clark

Doctor of Ministry

NPO Statement

Emerging adults in ministry without a deepening awareness of being God’s beloved may struggle to flourish and lead in their given contexts.

Key Benefits

Being the Beloved: Cultivating a Head to Heart Journey of Identity for Emerging Adults in Leadership and Ministry is a curriculum created to ground emerging adults in the love of God as they transition into adulthood and emerge as the next generation of Church leaders. Developmental psychology labels emerging adulthood as a time of significant change, instability and transition, while having to navigate key life decisions regarding education, career, and relationships. Identity formation is …