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Bird Richness As A Mediator Between Greenspace And Mental Health Relationships, Sihao Chena, Huaqing Wang, Wenyan Xu Mar 2025

Bird Richness As A Mediator Between Greenspace And Mental Health Relationships, Sihao Chena, Huaqing Wang, Wenyan Xu

Landscape Architecture and Environmental Planning Faculty Publications

Neighborhood greenspaces are widely known to benefit bird diversity and human mental health. However, whether bird richness mediates the relationship between greenspace and mental health is unknown. We ascertain such mediation effects in 294 census tracts in Los Angeles City. We obtained greenspace data from one-meter resolution satellite imagery, bird species data from eBird citizen science datasets, and prevalence of poor mental health from the US Centers for Disease Control and Prevention. Mediation analysis combined with spatial error models was used to assess the mediating effects while controlling for geographic, demographic, and socio-economic factors. We found that the higher greenspace …


Multiple Path Particle Dosimetry (Mppd) Model Total Dust Among Mineral Ore Processing Workers, Arif Susanto, Muhamad Rizky Yudhiantara, Edi Karyono Putro, Prayoga Kara, Anthony Andorful Manuel, Nurulia Hidayah Mar 2025

Multiple Path Particle Dosimetry (Mppd) Model Total Dust Among Mineral Ore Processing Workers, Arif Susanto, Muhamad Rizky Yudhiantara, Edi Karyono Putro, Prayoga Kara, Anthony Andorful Manuel, Nurulia Hidayah

Media Kesehatan Masyarakat Indonesia

Mineral ore processing generates dust, which poses a significant health risk to workers due to prolonged exposure. The aerodynamic properties of this dust allow it to be inhaled and deposited deep within the respiratory tract, increasing the risk of impaired respiratory function. This study aimed to quantify and assess the health risk associated with respirable dust exposure among workers in mineral ore processing areas using the Multiple Path Particle Dosimetry (MPPD) Model. The MPPD model was used to estimate the deposition of dust particles in various regions of the respiratory tract. A constant scenario with the average respirable dust concentration …


The Medicine From Nature; Finding The Antibacterial Power Of Essential Oils, Josi Maness, Seoyeon Kim, Eric T. Gillock Mar 2025

The Medicine From Nature; Finding The Antibacterial Power Of Essential Oils, Josi Maness, Seoyeon Kim, Eric T. Gillock

SACAD: Scholarly Activities

Essential oils are known to have pharmaceutical effects such as anti-inflammatory, antioxidant, and anticarcinogenic properties. These days, there are various types of essential oils that are commonly used for coughing or to promote good sleep.

We prepared 19 different essential oils to find the essential oil that has the most antibiotic properties by putting drops of oil on a soy agar plate with Serratia marcescens. As a result, cinnamon cassia essential oil was most effective, and five of them didn't have antibiotic properties.

We also tested with six different types of antibiotics, and as a result, only three of them …


The Impact Of Anthropogenic Infrastructure On Avian Reproductive Success: A Study Of House Wrens In Proximity To Highways, Nana-Esi Irie Hanson, Medhavi Ambardar Mar 2025

The Impact Of Anthropogenic Infrastructure On Avian Reproductive Success: A Study Of House Wrens In Proximity To Highways, Nana-Esi Irie Hanson, Medhavi Ambardar

SACAD: Scholarly Activities

Road infrastructure has multifaceted effects on bird populations, influencing various aspects of their ecology and behaviour. I investigated the impact of road infrastructure, particularly highways, on the reproductive success of House Wrens (Troglodytes aedon) in a rural area. I compared the reproductive success of House Wrens in sites close to a major highway (Sternberg Museum Nature Trail) with sites located farther away (along Big Creek) in Hays, KS. I hypothesized that House Wrens near highways would exhibit lower reproductive success. I recorded metrics of reproductive success, traffic volumes, and noise levels. House wrens at the Big Creek site had higher …


The Role Of Chitosan In Increasing The Mechanical And Antibacterial Properties Of Paper, Khurshid Khamidulla Ugli Khaydullaev, Jaloliddin Faxriddin Ugli Ungarov, Munavvar Umar Kizi Iskandarova, Yorqinjon Tulqin Ugli Ergashev, Guzal Yusupovna Akmalova, Elmurod Abduqodirovich Egamberdiev Mar 2025

The Role Of Chitosan In Increasing The Mechanical And Antibacterial Properties Of Paper, Khurshid Khamidulla Ugli Khaydullaev, Jaloliddin Faxriddin Ugli Ungarov, Munavvar Umar Kizi Iskandarova, Yorqinjon Tulqin Ugli Ergashev, Guzal Yusupovna Akmalova, Elmurod Abduqodirovich Egamberdiev

Technical science and innovation

Chitosan is also widely used in the paper industry to improve paper production and paper properties. Indeed, the molecular structure of chitosan is similar to cellulose, which contributes to the formation of a strong compound. Due to the presence of chitin (-NHCOCH3) functional groups in chitosan (-NH2), these groups are insoluble in water, but soluble in a solution of chitosan acid with deacetylation levels above 60%. On the contrary, chitin does not dissolve. Chitin and chitosan are insoluble in alkaline and organic solutions under normal conditions. In general, a high percentage of the amine (NH2 …


Hubungan Heart Rate Variability Dengan Global Longitudinal Strain Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Jakarta, Dwi Rendra Hadi, Lusiani Rusdi, Tri Juli Edi Tarigan, Arif Mansjoer Mar 2025

Hubungan Heart Rate Variability Dengan Global Longitudinal Strain Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Jakarta, Dwi Rendra Hadi, Lusiani Rusdi, Tri Juli Edi Tarigan, Arif Mansjoer

Jurnal Penyakit Dalam Indonesia

Introduction. Diabetes mellitus (DM) remains a major global health issue due to its direct consequences and complications, particularly cardiovascular complications. These complications are influenced by autonomic neuropathy, which can be assessed by Heart Rate Variability (HRV). Autonomic dysfunction is thought to impair heart function, which can potentially be predicted early by observing Global Longitudinal Strain (GLS). The relationship between HRV and GLS has not been extensively studied. Therefore, this study aimed to identify the relationship between HRV and GLS.

Methods. A cross-sectional study with a population of adult type 2 DM patients residing in Jakarta in December 2020. …


Women’S Health Considerations In Traumatic Brain Injury, Sindhoori Nalla Mar 2025

Women’S Health Considerations In Traumatic Brain Injury, Sindhoori Nalla

Department of Rehabilitation Medicine Faculty Papers

Purpose of Review: Biological sex differences are an important factor to consider when treating TBI, as there can be a disproportionate manifestation of symptoms and recovery process when comparing females to males. Historically, these differences have not been well studied, and there is still much to be understood as to why these differences exist. Recent Findings: A number of factors are thought to contribute to disparities with women who have a TBI, including lack of well-designed research studies focused on women, hormonal fluctuations at the time of and as a result of a TBI, psychosocial comorbidities, and societal norms/expectations. While …


Numaswitch, A Novel Biochemical Platform For Efficient Peptide And Protein Production, Christian Schwarz, Roxann Guerrette, Bach-Ngan Wetzel Mar 2025

Numaswitch, A Novel Biochemical Platform For Efficient Peptide And Protein Production, Christian Schwarz, Roxann Guerrette, Bach-Ngan Wetzel

Microbial Engineering III (MEIII)

Please click Additional Files below to see the full abstract


From Civic Duties To Democratic Mandates: The Theoretical Framework Of Mill And Tocqueville On Compulsory Voting In The U.S., Olivia Claire Luttrell Mar 2025

From Civic Duties To Democratic Mandates: The Theoretical Framework Of Mill And Tocqueville On Compulsory Voting In The U.S., Olivia Claire Luttrell

Undergraduate Honors Theses

This thesis examines the treatment of jury duty and voting in the United States through the philosophical framework of John Stuart Mill and Alexis de Tocqueville. While jury duty is legally mandated, voting remains optional, despite both civic responsibilities being foundational to democratic participation. This research explores the historical, theoretical, and practical implications of voting becoming compulsory in the United States, as it is in other democratic nations. The analysis includes a comparative case study of the impact of Australia’s mandatory voting to evaluate whether it could become compulsory in the U.S. Both philosophers offer insightful knowledge on the role …


Crispr-Induced Mutagenesis Of Arabidopsis Thaliana Gene Apetala3, Hazel Frans, Tara Phelps-Durr Mar 2025

Crispr-Induced Mutagenesis Of Arabidopsis Thaliana Gene Apetala3, Hazel Frans, Tara Phelps-Durr

SACAD: Scholarly Activities

This project aims to create CRISPR-CAS9 mutations in the APETELA3 (AP3) gene of the model plant Arabidopsis thaliana. AP3 is a class B gene critical to the petal and stamen development of Arabidopsis flowers. AP3 is defined in a MADS domain, which binds directly to DNA and may be responsible for the expression of the CaRG-box genes. AP3 works in conjunction with PISTILLATA (PI), AGAMOUS (AG), APETALA1 (AP1), and SEPALLATA (SEP) genes to specify the development in the second and third whorls of the flower. While several alleles of AP3 already exist, these alleles are strong alleles that knockout gene …


Vaccination As A Protective Factor Against Hospitalization For Sars-Cov-2 Infections: An Observational Study Using Surveillance Data, Chandrayani Simanjorang, Kristin Mutiara Tarigan, Diva Anita Churiana Sudrajat, Rana Zahra Raniyah Wangsawinangun, Asy Syifa Anwari Zahra Mar 2025

Vaccination As A Protective Factor Against Hospitalization For Sars-Cov-2 Infections: An Observational Study Using Surveillance Data, Chandrayani Simanjorang, Kristin Mutiara Tarigan, Diva Anita Churiana Sudrajat, Rana Zahra Raniyah Wangsawinangun, Asy Syifa Anwari Zahra

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Death due to SARS-CoV-2 generally occurs in patients requiring hospital care (hospitalization). However, it is still unclear whether vaccination acts as a protective factor against hospitalization in SARS-CoV-2 patients in Indonesia. This study examines the association between vaccination and hospitalization among SARS-CoV-2 patients. It employs a quantitative, cross-sectional design using secondary data from SARS-CoV-2 surveillance records at the Jakarta Health Agency (January–August 2021). Findings show that patients who received the 1st vaccine dose had a 0.34 times lower risk of hospitalization compared to unvaccinated individuals (aPOR=0.34; 95% CI=0.31–0.38). Those who received the 2nd dose had an even lower risk (aPOR=0.16; …


Operating Fund Budget/ Expenditure Summary Report 2024-25, Csusb Budget Office Mar 2025

Operating Fund Budget/ Expenditure Summary Report 2024-25, Csusb Budget Office

University Budget Office records

No abstract provided.


Painting Rich Six-Dimensional Pictures Using Polarized Fluorescence Microscopy, Matthew D. Lew Mar 2025

Painting Rich Six-Dimensional Pictures Using Polarized Fluorescence Microscopy, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

No abstract provided.


Students Engage With Alumni, Explore Careers In Stem Fields During Career Immersion Excursion, Jeffery Woodard Mar 2025

Students Engage With Alumni, Explore Careers In Stem Fields During Career Immersion Excursion, Jeffery Woodard

Press Releases 2020-2029

No abstract provided.


Practices In Single Ventricle Repairs: Insights From Computational Fluid Dynamics On Cavopulmonary Connections – A Scoping Review, Olivia K. Osuch Mar 2025

Practices In Single Ventricle Repairs: Insights From Computational Fluid Dynamics On Cavopulmonary Connections – A Scoping Review, Olivia K. Osuch

Student Works

Abstract: Single-ventricle congenital heart defects require complex surgical strategies, with computation fluid dynamics (CFD) playing a growing role in optimizing cavopulmonary connections. This scoping review examines CFD-derived insights into power loss, hepatic flow distribution (HFD), and wall shear stress (WSS) across different Fontan geometries.

Methods: A search of available peer-reviewed literature (1995-2024) identified studies using CFD models to analyze hemodynamic performance in second and third-stage single-ventricle repairs. Studies were categorized based on surgical stage, anatomical variations, modeling assumptions, and key outcomes such as power loss, HFD, and WSS.

Results: Of 30 included studies, 28 analyzed power loss, 24 evaluated HFD, …


Geo-Ai For Wetland Classification And Evolutionary Analysis, Lirong Yin Mar 2025

Geo-Ai For Wetland Classification And Evolutionary Analysis, Lirong Yin

LSU Doctoral Dissertations

Wetlands, as a crucial component of the Earth's ecosystem, play a vital role in maintaining ecological balance and preserving biodiversity. However, wetlands are currently facing severe challenges, as both natural and human-induced factors are contributing to their global degradation. Gaining a deep understanding of the species composition and biodiversity within wetland-covered areas and accurately analyzing their changing trends not only helps assess the current and future state of wetlands but also provides strong support for the formulation of scientifically sound wetland conservation strategies. In recent years, the rapid development of geospatial intelligence and remote sensing technologies has brought new opportunities …


Sorption-Spectroscopic Method For Determining Mn Ions In Wastewater, Zulayho Asanalievna Smanova, Zukhra Ziyatovna Yakshieva, Nazira Kuchkarbayevna Madusmanova, Gulyorkhon Otkir Qizi Miradkhamova Mar 2025

Sorption-Spectroscopic Method For Determining Mn Ions In Wastewater, Zulayho Asanalievna Smanova, Zukhra Ziyatovna Yakshieva, Nazira Kuchkarbayevna Madusmanova, Gulyorkhon Otkir Qizi Miradkhamova

Technical science and innovation

In this article, the processes of metal complex synthesis are studied in detail. Zinc OEDF+NTF complexation reactions were carried out in the presence of polyhydric alcohols, ethylene glycol, glycerol, and citric acid. For the first time, the synergistic efficiency of a mixture of zinc OEDF+NTF complexes with methyldiethanolamine, used as an inhibitor of mineral salt accumulation, was studied. It was found that when selecting the components in equivalent amounts, the inhibition efficiency of the composition is at least 90%. The high efficiency of inhibiting mineral salt accumulation in the composition is due to the presence of methyldiethanolamine, alkylimidazoline, and their …


The Influence Of Dispersed Fillers On The Mechanical Properties Of Sulfur Polymer Heterocomposites, Erkin Abdukhafizovich Rakhmatov, Durdiymurad Gurbanovich Gadamov, Umida Alijonovna Ziyamukhamedova, Jasurbek Himmat Ugli Nafasov, Elbek Tukhtanazar Ugli Turgunaliev, Shokhjakhon Uktam Ugli Abdurakhimov Mar 2025

The Influence Of Dispersed Fillers On The Mechanical Properties Of Sulfur Polymer Heterocomposites, Erkin Abdukhafizovich Rakhmatov, Durdiymurad Gurbanovich Gadamov, Umida Alijonovna Ziyamukhamedova, Jasurbek Himmat Ugli Nafasov, Elbek Tukhtanazar Ugli Turgunaliev, Shokhjakhon Uktam Ugli Abdurakhimov

Technical science and innovation

This article discusses improving the physical, mechanical, and operational properties of composite materials modified with sulfur-containing plasticizers used in the modern construction industry. Furthermore, based on an in-depth analysis of the literature, the types and sizes of fillers and the significance of their mixing technology in the formation of a structure with low porosity of a composite material with a sulfur binder have been studied. The article thoroughly describes a method for obtaining a composite material with a stable sulfur-containing binder, the processes of preparing a solid filler, impregnating the filler with an organic modifier, humidifying and heating the filler …


Lanthorn, Vol. 59, No. 14, March 31, 2025, Grand Valley State University Mar 2025

Lanthorn, Vol. 59, No. 14, March 31, 2025, Grand Valley State University

Volume 59, August 5, 2024 – April 14, 2025

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.


Infectious Disease Traveler Mobile Application Based On Need Assessment Analysis In Malaysian Students, Farindira Vesti Rahmasari, Wulan Noviani, Cahya Damarjati, Titih Huriah, Ferika Indarwati, Umniyyah Agsanie, Tesaviani Kusumastiwi, Mallika Imwong, Chong Mei Chan Mar 2025

Infectious Disease Traveler Mobile Application Based On Need Assessment Analysis In Malaysian Students, Farindira Vesti Rahmasari, Wulan Noviani, Cahya Damarjati, Titih Huriah, Ferika Indarwati, Umniyyah Agsanie, Tesaviani Kusumastiwi, Mallika Imwong, Chong Mei Chan

Media Kesehatan Masyarakat Indonesia

Major risks to world health are posed by infectious illnesses such as leptospirosis, hepatitis, malaria, dengue, and tuberculosis. Many diverse measures have been taken to fight infectious disease. However, cases persist despite these efforts, emphasizing the necessity for creative methods of managing and preventing disease. As it integrates mobile health (mHealth) solutions, the research can potentially revolutionize travel medicine. It is vital to give easily accessible and trustworthy health information that can lower the risks of infectious disease while traveling, as the number of students and the general public who travel is increasing. It was qualitative research. Qualitative study explores …


Developing Scholarship Of Teaching And Learning (Sotl) On A Regional Campus, Shawn Boyne, Rosemary Erickson Johnsen Mar 2025

Developing Scholarship Of Teaching And Learning (Sotl) On A Regional Campus, Shawn Boyne, Rosemary Erickson Johnsen

eJournal of Public Affairs

How can academic affairs administrators foster robust Scholarship of Teaching and Learning practices on a regional baccalaureate campus? Fulfilling tenure-system faculty requirements for scholarly research at a teaching institution alongside 4-4 teaching loads is a challenge, but supporting faculty in SoTL engagement shows them how it draws on their expertise to yield meaningful benefits for themselves as teacher-scholars and for their students. To lay a solid foundation for a new programmatic emphasis on SoTL, academic leadership at the Crookston campus of the University of Minnesota harnessed system resources available through the Center for Educational Innovation to a supportive cohort model. …


Optimizing Transcription Efficiency Through Mutations In The T7 Rna Polymerase, Claire N. Novak Mar 2025

Optimizing Transcription Efficiency Through Mutations In The T7 Rna Polymerase, Claire N. Novak

Honors Program: Senior Projects (Public)

The production of RNA is vital for many commercial and research purposes, with one of the more notable reasons being vaccine production. The RNA polymerase, derived from T7 bacteriophage, is commonly used for RNA production due to its ability to produce full-length RNA transcripts. However, researchers have faced limitations in optimizing this polymerase. For example, the polymerase generates heterogeneous RNA products that require additional purification steps during RNA production. Here, we selected three amino acid point substitutions based on a recent publication from Moderna that showed increased RNA purity compared to the wild type T7 RNA polymerase sequence. We created …


The Effects Of Interpretation On Children Of Immigrants, Crystal Carrillo Mar 2025

The Effects Of Interpretation On Children Of Immigrants, Crystal Carrillo

Honors Program: Senior Projects (Public)

Translation focuses on converting written text from one language to another with accuracy and cultural nuance, while interpretation involves real-time verbal communication, requiring quick comprehension and delivery, often in high-pressure settings like conferences or medical appointments. This essay also explores the experiences of bilingual children who have interpreted for family members in healthcare settings. It investigates the emotional and psychological burden that arises from this role, particularly when individuals are required to interpret complex medical information, traumatic histories, or sensitive diagnoses. The findings reveal that informal family interpreters often face significant stress, social pressure, and potential emotional harm, impacting their …


Liver Tet1 Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease, Hongze Chen, Muhammad Azhar Nisar, Joud Mulla, Xinjian Li, Kevin Cao, Shaolei Lu, Katsuya Nagaoka, Shang Wu, Peng Sheng Ting, Tung Sung Tseng, Hui Yi Lin, Xiao Ming Yin, Wenke Feng, Zhijin Wu, Zhixiang Cheng, William Mueller, Amalia Bay, Layla Schechner, Xuewei Bai, Chiung Kuei Huang Mar 2025

Liver Tet1 Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease, Hongze Chen, Muhammad Azhar Nisar, Joud Mulla, Xinjian Li, Kevin Cao, Shaolei Lu, Katsuya Nagaoka, Shang Wu, Peng Sheng Ting, Tung Sung Tseng, Hui Yi Lin, Xiao Ming Yin, Wenke Feng, Zhijin Wu, Zhixiang Cheng, William Mueller, Amalia Bay, Layla Schechner, Xuewei Bai, Chiung Kuei Huang

School of Public Health Faculty Publications

Global hepatic DNA methylation change has been linked to human patients with metabolic dysfunction-associated steatotic liver disease (MASLD). DNA demethylation is regulated by the TET family proteins, whose enzymatic activities require 2-oxoglutarate (2-OG) and iron that both are elevated in human MASLD patients. We aimed to investigate liver TET1 in MASLD progression. Depleting TET1 using two different strategies substantially alleviated MASLD progression. Knockout (KO) of TET1 slightly improved diet induced obesity and glucose homeostasis. Intriguingly, hepatic cholesterols, triglycerides, and CD36 were significantly decreased upon TET1 depletion. Consistently, liver specific TET1 KO led to improvement of MASLD progression. Mechanistically, TET1 promoted …


The Impact Of Art In Medicine Training And Its Effectiveness On Professionalism And Interpersonal Skills: A Prospective Study., Maria Musri, Atif Nehvi, Shireen Chacko, Glenn Eiger, Nazanin Moghbeli Mar 2025

The Impact Of Art In Medicine Training And Its Effectiveness On Professionalism And Interpersonal Skills: A Prospective Study., Maria Musri, Atif Nehvi, Shireen Chacko, Glenn Eiger, Nazanin Moghbeli

Einstein Health Papers

INTRODUCTION: Internal Medicine residents in The United States of America (USA) need to demonstrate competency in the Accreditation Council for Graduate Medical Education (ACGME) core areas to meet training requirements. Two of these core competencies are professionalism and interpersonal/communication skills. Medical humanities can positively influence trainee development by cultivating these skills. There is limited literature on the use of art-based programs to enhance communication and professionalism skills among residents aside from the original FRAME workshop. We have designed a six-part series called "Using Art for Professionalism and Communication Skills in Medical Education" (UAPCMedEd) that implements visual arts training strategies to …


Lonza Leadership Visits Unh's Tissue Culture Lab, Keith Testa Mar 2025

Lonza Leadership Visits Unh's Tissue Culture Lab, Keith Testa

UNH Today Archive

No abstract provided.


Progesterone Receptor In Uterine Glands Is Required For Pregnancy Establishment In Mice, Greeshma Sai Bayammagari, Sai Goutham Reddy Yeddula, Sarayut Winuthayanon, Francesco J Demayo, John P Lydon, Thomas E Spencer, Andrew M Kelleher Mar 2025

Progesterone Receptor In Uterine Glands Is Required For Pregnancy Establishment In Mice, Greeshma Sai Bayammagari, Sai Goutham Reddy Yeddula, Sarayut Winuthayanon, Francesco J Demayo, John P Lydon, Thomas E Spencer, Andrew M Kelleher

Faculty, Staff and Students Publications

Embryo implantation is a critical event in the establishment of pregnancy, and implantation failure is a major cause of pregnancy loss in women. Coordinated, cell-type specific responses to the ovarian steroid hormones, estrogen, and progesterone, within the endometrium underlie successful embryo implantation and pregnancy establishment. In this study, we utilized a glandular epithelium (GE) specific Cre recombinase mouse line that is only active in the adult (Prss29-Cre) to determine the biological role of progesterone receptor (PGR) in uterine glands during pregnancy. Conditional ablation of PGR specifically in the GE compromised fertility due to defects in uterine receptivity and embryo implantation. …


Limosilactobacillus Reuteri Promotes The Expression And Secretion Of Enteroendocrine- And Enterocyte-Derived Hormones, Sara C Di Rienzi, Heather A Danhof, Micah D Forshee, Ari Roberts, Robert A Britton Mar 2025

Limosilactobacillus Reuteri Promotes The Expression And Secretion Of Enteroendocrine- And Enterocyte-Derived Hormones, Sara C Di Rienzi, Heather A Danhof, Micah D Forshee, Ari Roberts, Robert A Britton

Faculty, Staff and Students Publications

Intestinal microbes can beneficially impact host physiology, prompting investigations into the therapeutic usage of such microbes in a range of diseases. For example, human intestinal microbe Limosilactobacillus reuteri strains ATCC PTA 6475 and DSM 17938 are being considered for use for intestinal ailments, including colic, infection, and inflammation, as well as for non-intestinal ailments, including osteoporosis, wound healing, and autism spectrum disorder. While many of their beneficial properties are attributed to suppressing inflammatory responses, we postulated that L. reuteri may also regulate intestinal hormones to affect physiology within and outside of the gut. To determine if L. reuteri secreted factors …


Uterine Pgrmc2 Deficiency Attenuates Endometrial Hyperplasia And Cancer And Prolongs Lifespan In A Pten Loss-Of-Function-Induced Cancer Model, Nicole C Kelp, Cindy A Pru, Sandeep Paudel, John P Lydon, J Julie Kim, John J Peluso, James K Pru Mar 2025

Uterine Pgrmc2 Deficiency Attenuates Endometrial Hyperplasia And Cancer And Prolongs Lifespan In A Pten Loss-Of-Function-Induced Cancer Model, Nicole C Kelp, Cindy A Pru, Sandeep Paudel, John P Lydon, J Julie Kim, John J Peluso, James K Pru

Faculty, Staff and Students Publications

The expression of members of the progesterone receptor membrane component (PGRMC) family, particularly PGRMC1, is elevated in diverse types of cancers, particularly those of the female reproductive system. While xenograft tumor studies using human transformed cell lines in immunocompromised mice have suggested that PGRMC1 enhances tumor growth and chemoresistance, the exact role of members of the PGRMC family in cancer development in vivo remains unclear. In this study, we examined the effect of deleting Pgrmc2 on the development of endometrial hyperplasia and cancer using a murine phosphatase and tensin homologue (Pten) conditional loss-of-function model. We previously established that …


Reweighting Configurations Generated By Transferable, Machine Learned Models For Protein Sidechain Backmapping, Jacob Monroe Mar 2025

Reweighting Configurations Generated By Transferable, Machine Learned Models For Protein Sidechain Backmapping, Jacob Monroe

Chemical Engineering Faculty Publications and Presentations

Multiscale modeling requires the linking of models at different levels of detail, with the goal of gaining accelerations from lower fidelity models while recovering fine details from higher resolution models. Communication across resolutions is particularly important in modeling soft matter, where tight couplings exist between molecular-level details and mesoscale structures. While multiscale modeling of biomolecules has become a critical component in exploring their structure and self-assembly, backmapping from coarse-grained to fine-grained, or atomistic, representations presents a challenge, despite recent advances through machine learning. A major hurdle, especially for strategies utilizing machine learning, is that backmappings can only approximately recover the …