Digital Commons Network^™

A 3-Week Pause Versus Continued Bruton Tyrosine Kinase Inhibitor Use During Covid-19 Vaccination In Individuals With Chronic Lymphocytic Leukaemia (Improve Trial): A Randomised, Open-Label, Superiority Trial, Helen M. Parry, Claire Hutchinson

Peninsula Medical School

Background: Chronic lymphocytic leukaemia is the commonest leukaemia and is associated with profound immunosuppression. Bruton tyrosine kinase inhibitors (BTKi) have revolutionised chronic lymphocytic leukaemia management; however, therapy impairs vaccine-induced immunity. We evaluated whether a 3-week pause of BTKi treatment improved spike protein receptor binding domain (RBD) immunity to SARS-CoV-2 booster vaccination while maintaining disease control. Methods: We performed an open-label, two-arm, parallel-group, randomised trial in secondary-care haematology clinics in 11 UK hospitals. Participants aged 18 years or older, diagnosed with chronic lymphocytic leukaemia, and currently taking BTKi therapy (frontline or relapsed setting) for at least 12 months were eligible. Participants …

Galectin-1 Inhibition As A Strategy For Malignant Peripheral Nerve Sheath Tumor Treatment, Hsiao-Chi Wang, Keila E Torres, Roger Xia, Marcio H Malogolowkin, Ssu-Wei Hsu, Ching-Hsien Chen, Tsung-Chieh Shih

Faculty, Staff and Student Publications

Neurofibromatosis type 1 (NF1) is an inherited disorder that predisposes individuals to malignant peripheral nerve sheath tumors (MPNSTs), a highly aggressive sarcoma with limited treatment options and poor prognosis. This study explores the potential of targeting the interaction between Galectin-1 and Ras as a novel therapeutic strategy for MPNSTs. Through molecular docking, we identified critical residues involved in the Galectin-1 and H-Ras interaction. We developed LLS30, a compound designed to target this Ras-binding pocket on Galectin-1, and tested its efficacy. LLS30 effectively disrupted the Galectin-1/Ras interaction, causing Ras delocalization from the plasma membrane and inhibiting Ras signaling. In vitro experiments …

Bi-Level Energy Dispatch Optimisation For Peak Load Shaving In Microgrids With Battery Storage, Mohd Fakhizan Romlie, Abid Ali, Gm Shafiullah

Platform: A Journal of Engineering (PAJE)

Peak load periods in electrical networks result in significant power losses, straining generation capacity, and increasing operational costs. Strategically optimising electricity supply from battery storage-based distributed generation (DG) during these peak times can mitigate these losses and enhance grid efficiency through peak load shaving (PLS). However, electrical loads vary throughout the day and night. Thus, identifying peak and off-peak loads would be the most challenging task to complete before scheduling operations for batteries. This study presents a bi-level energy optimisation framework to identify the peak and off-peak loads and plan the energy dispatching operations for battery storage. The bi-level energy …

Quo Vadis Hak Atas Kesehatan Reproduksi: Analisis Rekonstruksi Pengaturan Aborsi Di Indonesia (Perbandingan Hukum Indonesia Dengan Perancis), Dian Kencana Putri, Erna Dyah Kusumawati

Jurnal Hukum & Pembangunan

Pembatasan akses aborsi di Indonesia menyebabkan banyak perempuan dengan kehamilan tidak diinginkan terpaksa berhadapan dengan hukum. Pembatasan aborsi yang mengakibatkan kriminalisasi ini dapat menyebabkan dilema moral bagi banyak perempuan yang mengalami kehamilan tidak diinginkan. Padahal aborsi berpotensi terjadi pada setiap perempuan berusia produktif di Indonesia. Aborsi di Indonesia merupakan tindakan ilegal dan aborsi hanya dapat dilakukan dalam dua kondisi saja, yakni kedaruratan medis dan kehamilan yang disebabkan perkosaan. Artikel ini menganalisa bagaimana sebenarnya substansi aborsi dapat dimasukkan pada kategori hak kesehatan reproduksi perempuan dan mengapa negara Indonesia perlu mengubah kebijakan dan hukum mengenai aborsi. Untuk melihat seberapa pentingnya negara harus …

Future Cities: Exploring Circularity For Sustainable Urban Cities, Benjamin Moral

Architecture and Planning Journal (APJ)

In an era marked by rapid urbanization, the imperative of sustainability looms large for future cities. The growing global urban population portends increased resource demand, environmental stress, and socio-economic challenges, compelling a shift towards circularity. Circular principles, aimed at minimizing waste and optimizing resource use, embody a regenerative vision for urban spaces. While this concept gains traction worldwide, comprehensive studies simplifying its application are scarce. This research examines and diagnoses how Circularity can revolutionize urban sustainability, with objectives to evaluate circular economy models and analyses case studies and benefits. Employing an exploratory research design, this study drew data from secondary …

Educational Mixed-Use Building Design And Its Connections To Community Engagement, Aman Ullah, Anosh Nadeem Butt, Syeda Arfa Quddusi, Mir Wali Shah, Iftikhar Haider

Architecture and Planning Journal (APJ)

Education and extracurricular activities play a critical role in improving individuals’ personalities and building a healthy community. Lack of educational facilities, unapproachable educational resources and invalidity of space for physical activities is a great obstacle to strong community building. Pakistan has been going through several economic and political crises that are making it difficult for the government to provide educational resources and opportunities for sports and physical activities to its people. Therefore, this study aims to explore how mixed-use educational buildings can facilitate individuals in gaining knowledge and education easily along with other recreational activities. Mixed-use building design will enable …

Profiling Competitive Malaysian Archers: Musculoskeletal Injuries And Related Risk Factors, Ambusam Subramaniam, Fariza Zainudin Fairus, Mon Redee Sut Txi

Baltic Journal of Health and Physical Activity

Background: Archery requires precision, strength, stamina, and attention, yet musculoskeletal injury data is scarce. The study aimed to profile the musculoskeletal injuries and the associated risk factors among Malaysian archers. Methods: A cross-sectional approach was used to recruit 165 elite archers. The Standardized Nordic Questionnaire (SNQ), adapted risk factors questionnaire, Pittsburgh Sleep Quality Index (PSQI), and Depression Anxiety Stress Questionnaire (DASS-21) were used to screen participants. Results: Shoulder (drawing arm) (54.5%), shoulder (bow arm) (56.4%), upper back (38.8%), lower back (38.2%), and neck (37.6%) musculoskeletal injuries were common. The injuries were reported during training (85.5%), accumulation/overuse injuries (72.1%), and sudden …

25 Conference Program - Submission Form For 2025 International Conference On Semiconductor Technology For Ultra Large-Scale Integrated Circuits And Thin Film Transistors (Ulsic Vs Tft 9), Yue Kuo

2025 International Conference on Semiconductor Technology for Ultra Large-Scale Integrated Circuits and Thin Film Transistors (ULSIC VS TFT 9)

No abstract provided.

Is Microbial Production A Good Option For Exceptionally Low Cost Monoclonal Antibodies For Global Access?, Vijay Yabannavar

Microbial Engineering III (MEIII)

Please click Additional Files below to see the full abstract

25 Conference Program - Microbial Engineering Iii: New Generation Of Cell Factory To Meet The Future Challenges And Seize New Opportunities, Eli Keshavarz-Moore, Thomas Sauer

Microbial Engineering III (MEIII)

No abstract provided.

Poor Cancer Prevention And Detection In Zimbabwe, Kenyon C. Chipman

Journal of Nonprofit Innovation

Abstract

In the aftermath of the HIV/AIDS epidemic, Sub-Saharan Africa, particularly Zimbabwe, has witnessed a surge in noncommunicable diseases such as cancer. Despite the decline in HIV/AIDS and other cancer-associated illnesses like HPV, these diseases have set the stage for a growing cancer epidemic. Key contributing factors to this rise include a lack of knowledge about cancer among both patients and health professionals, the prevalence of cancer-associated communicable diseases, and limited accessibility to early detection and prevention services and resources. These factors have led to late diagnoses, increased burden on the healthcare system, and adverse effects on individuals and families. …

Epigenetic Regulation And Tumor Suppressive Function Of Lncrna Ep300-As1 In Nasopharyngeal Carcinoma Through Activation Of Tfap2c Binding To Cst6: Implications For Diagnosis, Prognosis, And Therapy, Chengliang Xing, Shun Ding, Tingting Duan, Zhiqun Li, Jinren Yan, Yu Kuang, Qibing Liu, Zhonglin Mu

Integrated Health Sciences Faculty Research

The long non-coding RNA EP300-AS1 (lncRNA EP300-AS1), identified as a potential regulatory factor in various cancers, remains underexplored in nasopharyngeal carcinoma (NPC). This study investigated EP300-AS1’s regulatory mechanisms in NPC, particularly its interaction with transcription factor AP-2 Gamma (TFAP2C) and its effect on cystatin E/M (CST6) expression. Employing clinical samples and NPC cell lines, we conducted in vitro and in vivo xenograft experiments to assess the impacts of modulating EP300-AS1 expression. Techniques such as CCK8, migration, scratch, apoptosis assays, cell cycle analysis, immunoblotting, and fluorescence experiments elucidated EP300-AS1’s role in NPC. The interaction between EP300-AS1 and TFAP2C in regulating CST6 …

The Effect Of Compression Training With Distance Variation On The Development Of Certain Types Of Speed And Offensive Skills In Young Handball Players, Ammar Taher Mandil

Modern Sport

The significance of this research lies in the use of pressure training exercises with varying distances to enhance certain types of speed and offensive skills in handball. Regarding the research problem: Based on the researcher’s modest experience, his follow-up of the club’s handball team, and his attendance at the team’s matches, he observed that the players’ speed does not meet the required level. This allows opposing players to quickly return and thwart attacks, which leads to a decline in progress and success, and subsequently, a lower goal-scoring rate. This observation prompted the researcher to investigate this issue in depth in …

Vertical Resistance And Its Relationship With Speed-Strength And Biomechanical Variables During The Takeoff Phase And The Performance Of Selected Activities In Individual And Team Sports, Rusul Ahmed Hassan, Entisar K. Abdalkarim

Modern Sport

Jumping ability is a fundamental variable in many sports, as its execution requires an integration of muscular strength Q1 and certain biomechanical variables. This is particularly evident in gymnastics jumping events and jump shots in ball games, both of which rely on a high level of vertical resistance. Vertical resistance serves as an indicator of an athlete’s ability to overcome their body weight while counteracting gravitational force to achieve optimal performance. As such, it is considered one of the key factors in movements that demand explosive power and speed. The researchers believe that despite the significant relationship between vertical resistance, …

Exploration Of Recitation Program For Improving Student's Physics Concept: Study Literature, Muhammad Ibnu Shodiqin, How Shwu Pyng

Jurnal Pendidikan Sains

The main goal of learning physics is to help students master concepts. Students must possess a strong mastery of concepts, particularly fundamental ones in physics, to effectively solve problems. However, many students struggle with understanding physics concepts. A recitation program can enhance students' mastery of physics concepts. Using the recitation program increases students' concept mastery. This article examines how the program was developed. This research employs a literature review method. Vosviewer processed the data collected from Google Scholar, Scopus, Microsoft Academies, and Harzing's Publish or Perish. The results of the article synthesis show that the recitation program can improve students' …

Avifauna Of Kheri Morat National Park: Role Of Agricultural Habitat In Maintaining The Diversity Of Birds In The Presence Of Threats In Adjacent Forest Habitat, Syed Ali Hasnain Mosvi, Saeed Azam, Abdullah Ibrahim, Saleha Abbasi, Nadeem Munawar, Muhammad Arslan Asadi

Journal of Bioresource Management

Increasing land use for agricultural practices is commonly perceived as a threat to the avian diversity. However, a number of avian species depend on these croplands for food, water, and shelter. The present study was conducted in Khairi National Park, Pakistan, for the discourse of awareness gaps about the avifaunal diversity of the protected area and to compare the bird’s diversity in the agriculture fields and native forests. For the current study, the habitat was divided into two habitat categories, i.e., forest and croplands. The sampling was executed between February 2014 and February 2017. Stratified random sampling was used to …

Review On Biological Management Of Bactrocera Zonata Through Pathogenic Activity Of Beauveria Bassiana, Sana Ullah, Hafiz Muhammad Sajid Ali, Syed Husnain Kumail Naqvi, Muhammad Ziaullah, Farhan Ali, Sana Sarfaraz, Mamoona Kanwal

Journal of Bioresource Management

Bactrocera zonata is the destructive pest of peach, mango, and banana by causing significant economic losses. It reduces fruit quality which directly causes decline in export of these economical fruits. Many management strategies were carried to suppress the population of this invasive pest. The use of chemical insecticides in the orchard for control of B. zonata is restricted because insecticides cause several complications in fruit health and makes fruits unfit for human consumption. Due these drawbacks of chemical control, Biological control strategies are preferred for better management of B. zonata. Entomopathogenic fungi are potential bio-control agent against many insect …

Enforcement Activities And Profiling Techniques Of Wildlife Rangers In Nigeria's Lowland Forest Reserves: A Mixed-Methods Study On Wildlife Law Transgressions, Norris I. Erhabor, Gloria Aimien Erhabor

Journal of Bioresource Management

This mixed-methods study investigates the enforcement activities and profiling techniques employed by wildlife rangers in Nigeria's lowland forest reserves to address wildlife law transgressions. The research integrates enforcement strategies, socio-economic factors, community involvement, and governance structures to evaluate the effectiveness of ranger activities. Data collection was conducted in the Omo Biosphere Reserve, Gele Gele Forest Reserve, and Okomu National Park, utilizing both primary and secondary sources, including interviews with 24 wildlife rangers. Key findings reveal that unauthorized entry, possession of specific tools, and suspicious behaviors are primary indicators used by rangers to identify potential law violators. Poaching activities predominantly occur …

Dna Methylation In Periodontal Disease: A Focus On Folate, Folic Acid, Mitochondria, And Dietary Intervention, Elzbieta Pawlowska, Joanna Szczepanska, Marcin Derwich, Piotr Sobczuk, Nejat Düzgüneş, Janusz Blasiak

Pacific Faculty Work

Although periodontal disease (PD) is reported to be associated with changes in various genes and proteins in both invading bacteria and the host, its molecular mechanism of pathogenesis remains unclear. Changes in immune and inflammatory genes play a significant role in PD pathogenesis. Some reports relate alterations in cellular epigenetic patterns to PD characteristics, while several high-throughput analyses indicate thousands of differentially methylated genes in both PD patients and controls. Furthermore, changes in DNA methylation patterns in inflammation-related genes have been linked to the efficacy of periodontal therapy, as demonstrated by findings related to the cytochrome C oxidase II gene. …

Identification Of Xanthine Oxidase Inhibitors In Single-Clove Black Garlic Using Metabolomics And Molecular Docking Approaches, Abdul Aziz Setiawan, Shirly Kumala, Dian Ratih Laksmitawati, Ari Yuniarto, Nancy Dewi Yuliana

Makara Journal of Science

Black garlic is produced through controlled fermentation under specific temperature and humidity conditions, during which the Maillard reaction enhances its sensory properties and bioactivity. The anti-hyperuricemic potential of single-clove black garlic (SBG) remains unexplored. This study combined Ultra High-Performance Liquid Chromatography–High Resolution Mass Spectrometry-based metabolomics and an in-silico approach to identify the potential xanthine oxidase inhibitors (XOI) in SBG. Methanolic extracts (10 ppm) exhibited xanthine oxidase inhibition ranging from 50.09% to 68.01%, which is comparable to allopurinol (78.74%) at the same concentration. Metabolomic profiling tentatively identified 45 compounds, and orthogonal partial least squares analysis revealed seven metabolites as strongly correlated …

Study On Predisposing Factors And Control Measures Against Cryptosporidiosis In Buffalo Calves At Cattle Colony Hyderabad, Sindh, Pakistan, Ali Ul Murtaza, Abdul Latif Bhutto, Jam Kashif Zaman, Mansoor Tariq, Amjad Hussain Mirani, Riaz Ahmed Laghari, Pervez Ahmed Khoso, Muhammad Mohsen Rahimoon, Abdul Saboor, Fayaz Hussain

Journal of Bioresource Management

The current study looked at the variables affecting the frequency of Cryptosporidium Parvum in buffalo calves at the Hyderabad Cattle Colony. From calves, 100 fecal samples were taken in total, preserved, and analyzed using direct smear and Ziehl-Neelsen staining methods. 74 percent of the samples tested positive for Cryptosporidium Parvum. Disease rates were higher in Nili Ravi calves (86 %) compared to Kundhi calves (62 %), with a statistically significant difference (p

Co-Inertia Analysis Of Data Structured In Groups Of Individuals, Marien Ngouabi University, Brazzaville, Congo, R.O. Malouata, M. Koukouatikissa Diafouka, G.C. Louzayadio

Baku Mathematical Journal

This paper presents an overview of methods for the analysis of data structured in N multiblocks of variables partitioned in M multigroups of individuals. More specifically, successive generalized co-inertia analysis (SGCIA) and its dual method, which are two unifying approaches for multiblock data analysis and multigroup data analysis. Examples are given to illustrate the use of the proposed methods.

A Nonlinear Cross Diffusion Model Analysis By Using Holling Type Iii Functional Response To Describe Fish And Zooplankton Dynamics Taking Into Account The Fishing Effect In The Ecosystem, University Of Nazi Boni, Bobo Dioulasso, Burkina Faso, W. Ouedraogo, H. Ouedraogo

Baku Mathematical Journal

In this paper, we analyse a mathematical model of a cross-diffusion and selfdiffusion system describing the dynamics of fish and zooplankton population. A type III Holling functional response was used in the formulation of the model taking into account the effect of fishing in the ecosystem. Satisfactory results concerning the local and global existence properties of the solutions. Persistence conditions as well as the local stability of equilibrium states are established. We have shown in particular that, under certain conditions, cross-diffusion can trigger the emergence of spatial patterns. Numerical experiments are performed to visualize complex spatial patterns and dynamic behaviour …

Critical Thinking Skills: Improvement Through Learning Ownership-Pbl Approach On Students, Ulfa Risqillah, Dwi Listyorini, Sitoresmi Prabaningtyas, Siti Salina Mustakim

Jurnal Pendidikan Sains

Through a method called "Learning Ownership," students actively participate in the educational process and comprehend the context, objectives, and applications of the content they have learned. A learner can customize each educational encounter to align with their present and future learning goals once they have control over their learning processes. The skills and practices required for ownership are highly versatile and applicable in various educational environments. The aim of this study was to unveil the effect of the learning ownership-PBL model on students' critical thinking skills. The sampling technique used in this research was random sampling, which consisted of 2 …

Nitrogen Application Enhances The Radiation Use Efficiency And Quality Of Cotton (Gossipum Hirsutum L.) Under Divergent Agro-Ecological Conditions Of Pakistan, Amjed Ali, Safdar Hussain, Wajid Nazeer, Muhammad Sarwar, Masood Qadir, Mubashar Nadeem, Javeria Sherani

Journal of Bioresource Management

Cotton being a cash crop plays a pivotal role in the economy of Pakistan. Climate change has a pronounced impact on radiation use efficiency and quality of cotton fiber. To find out how nitrogen affected the radiation use efficiency and fiber quality of cotton cultivars in Punjab, a field study using a split-plot design was carried out. The study under representation was conducted in three different locations over the course of two years (2016 and 2017): Adaptive Research Farm in Dera Ghazi Khan, The Regional Agriculture Research Institute, Bahawalpur and The College of Agriculture, University of Sargodha. Three cotton cultivars …

Impact Of Climate Change On The Diversity And Abundance Of Wintering Birds At A Northern African Wetland - Case Study Of Oglat Eddaira Wetland (Naama, Western Algeria), Ahmed Toufik Youcefi, Gouacem Ali, Litim Kouider, Haddi Leila, Messaoui Fatima

Journal of Bioresource Management

The Mediterranean regions have been classified as the areas of the world most susceptible to the effects of environmental change. These regions are sensitive to drought and rising temperatures and with heightened aridity in the next several years. The purpose of this paper is to study the effects of climate change on the diversity and abundance of wintering birds in the Oglat Eddaira wetland located in western Algeria and classified in the Ramsar list. This study is based on the comparison between some indices of biodiversity: species richness, abundance, Shannon-Weiner and Simpson Index, during the period 2015 to 2024 and …

Aerial Phytomass And Carbon Sequestrated By The Kitshanga Forest Massif In The Wamba Valley In Dr-Congo, Mayanu Pemba, Ntalakwa Makolo, Kidikwadi Tango, Lubini Ayingweu

Journal of Bioresource Management

Aerial phytomass and carbon sequestrated by the Kitshanga forest massif in the Wamba valley in DR-Congo. The general objective was to evaluate the aerial phytomass and the carbon contained in the ligneous tissues of the trees. Specifically, the research aims to: (i) inventory all individuals in the Kitshanga gallery forest; (ii) identify the species in the study area; (iii) determine the floristic composition and density of the stand studied and (iv) evaluate the phytomass and the carbon sequestered by this vegetation. Inventory devices full on 1 hectare subdivided by 400 m² to obtain 25 plots which constitute the size of …

Coastal Community Perspectives On Marine Resource Conservation And Access In Rote Island, Indonesia, Nara Wisesa

Oral Presentations

Indonesia’s coastal and marine environment supports high marine biodiversity, with conservation efforts aimed at sustainable management. Marine Protected Areas (MPAs), such as the Savu Sea MPA, play a key role in these efforts. Rote Island, located on the eastern side of this MPA, has coastal communities heavily reliant on marine resources, primarily fishing and seaweed farming. While conservation measures impact local resource access, there is limited research on their socio-cultural dimensions, particularly from the perspective of local stakeholders. Although conservation should prioritize local communities, studies indicate minimal involvement in planning and implementation. This study examines how marine conservation affects Rote’s …

Evaluating Coal-Jatropha Curcas Composite Briquettes As Sustainable Fuel Alternatives, Amad Ullah Khan, Muhammad Saleem, Muhammad Abas, Zakir Ullah, Khan Muhammad, Farida Anjum, Aamer Sharif, Melkamu Tadesse Getachew

Research outputs 2022 to 2026

Coal is a major fuel source but raises environmental concerns. This study investigated the feasibility of utilizing a composite briquette sustainable fuel produced from subbituminous coal and Jatropha curcas biomass. Briquettes were prepared with varying weight ratios of coal to J. curcas biomass (90:0–0:90) using corn starch as a binder. The influence of this ratio on the briquettes’ properties was comprehensively evaluated through proximate analysis, ultimate analysis, scanning electron microscopy (SEM), and X-ray fluorescence (XRF) analysis. The results revealed that increasing the J. curcas content in the briquettes gradually decreased the moisture content, ash content, and fixed carbon content while …

Cytosimplex: Visualizing Single-Cell Fates And Transitions On A Simplex, Jialin Liu, Yichen Wang, Chen Li, Yichen Gu, Noriaki Ono, Joshua Welch

Faculty, Staff and Student Publications

Summary: Cells differentiate to their final fates along unique trajectories, often involving multi-potent progenitors that can produce multiple terminally differentiated cell types. Recent developments in single-cell transcriptomic and epigenomic measurement provide tremendous opportunities for mapping these trajectories. The visualization of single-cell data often relies on dimension reduction methods such as UMAP to simplify high-dimensional single-cell data down to an understandable 2D form. However, these dimension reduction methods are not constructed to allow direct interpretation of the reduced dimensions in terms of cell differentiation. To address these limitations, we developed a new approach that places each cell from a single-cell dataset …