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Eating The Fat Of The Land: The Work Of Coxiella Burnetii To Traverse Intracellular Lipid Landscapes, Charlie Porto

Theses & Dissertations

Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q fever in humans. With primary hosts in livestock ruminants, C. burnetii is endemic globally, presenting significant health risks to agricultural workers and herd health at large. Numerous wild animal reservoirs exist, increasingly threatened by expanding livestock ranges. Furthermore, with a low infectious dose through aerosol transmission, the CDC considers C. burnetii a potential bioweapon, though in humans a large amount of infections persist subclinically, occasionally progressing to pneumonia and hepatitis with chronic infections leading to endocarditis.

The parasitic life cycle of C. burnetii is biphasic, a small …

Wildfire Smoke And U.S. Law, Michael B. Gerrard

Faculty Scholarship

Many of the most wicked feedback effects of climate change relate to wildfire smoke. In some places the greenhouse gases poured into the atmosphere by wildfires exceed the reductions achieved by all efforts to fight climate change. At the same time, climate change is a major reason why wildfires are becoming more frequent and intense. Climate change and wildfires feed each other. However, environmental law and climate policy have paid relatively little attention to wildfires. The smoke from these fires — a major cause of illness and death, even thousands of miles from the blazes — is mostly unregulated. Efforts …

Misogyny In Medicine’S Margins: Patients’ And Physicians’ Conflicts, Challenges, And Camaraderie In Endometriosis Care, Malavika Eby , '25

Senior Theses, Projects, and Awards

No abstract provided.

Understanding The Stereotypes, Emotions, And Behaviors Towards Introverts In The Workplace, Kristen M. Fisher

Psychology Theses & Dissertations

The present study utilizes the SCM and the BIAS Map to understand perceptions of introverts within the workplace and highlight potential approaches to mitigate introversion mistreatment. It was hypothesized that, when compared to extraverted employees, introverted employees would be perceived as lower in warmth and competence, receive more emotional responses of contempt, more behavioral responses of passive harm, and that contempt would mediate the relationship between competence and passive harm. Conversely, it was hypothesized that extraverts would be perceived as higher in warmth and competence, receive more emotional responses of admiration, more behavioral responses of active facilitation, and that admiration …

The Impact Of Success Coaching On Psychological Well-Being And Sense Of Belonging In First-Year College Students, Lashay Y. Mcqueen

Educational Leadership & Workforce Development Theses & Dissertations

As higher education institutions seek to assist students with the first-year transition, coaching is one intervention shown to increase academic performance and retention rates (Capstick et al., 2019). Along with academics, fostering student success from a holistic perspective is imperative (Bentrim & Henning, 2022). The purpose of this study was to determine the impact of participation in success coaching on the psychological well-being and sense of belonging for first-year college students. The study also investigated the impact of success coaching on first-generation students. Existing data were used to compare participation in success coaching to overall psychological well-being and sense of …

Nanosecond Pulsed Electric Field And Plasma Jets For Cancer Therapy, Edwin Ayobami Oshin

Biomedical Engineering Theses & Dissertations

Nanosecond pulsed electric field (nsPEF) employs nanosecond-duration, high voltage pulses to induce oxidative stress, leading to temporary or permanent damage to cells or tissue (also known as reversible and irreversible electroporation), and has been considered a promising approach for cancer therapy. In parallel to this, nanosecond pulsed atmospheric pressure plasma jets (ns-APPJs) have also shown to be effective in inactivating cancer cells or increasing sensitivity of cells to electric fields. ns-APPJs are known to generate reactive chemical agents, including reactive oxygen and nitrogen species (RONS) which induces oxidative stress resulting in cell proliferation, apoptosis, and necrosis. In this dissertation, a …

Development Of Laser-Induced Graphene-Based Bioanode Incorporating Thylakoid For Harvesting Energy, Amit Sarode

Biomedical Engineering Theses & Dissertations

Thylakoid-Based Biofuel Cells (TBFCs) present significant potential as renewable power sources; however, their development is impeded by challenges including delicate thylakoid membranes, limited electron transport efficiency, stability and dependence on expensive mediators. This study aimed to address these challenges by fabricating a novel photo-driven bioanode through the integration of Laser-Induced Graphene (LIG), Nb₄C₃T_x MXene, and thylakoid membranes. The fabrication process involved laser engraving to generate porous LIG electrodes, followed by MXene drop casting and thylakoid immobilization to enhance electrochemical performance and surface area. Morphological characterization supported that MXene incorporation increased active sites and surface roughness, …

Low Dissolved Oxygen Operation Enhances Biological Phosphorus Removal In Wastewater Treatment, Haley Morgan

Civil & Environmental Engineering Theses & Dissertations

Biological phosphorus (bio-P) removal occurs when bacteria are exposed to anaerobic/aerobic conditions that stimulate polyphosphate-accumulating organisms (PAOs) to uptake phosphorus. In most treatment plants, dissolved oxygen (DO) concentrations in the aeration tanks are commonly at or above 2.0 mg O₂/L, which is often referred to as the most optimal aeration condition for bio-P. If bio-P can happen efficiently at lower DO (< 0.3 mg O₂/L), then the energy demand of aeration can be decreased appreciably. This research was conducted in a biological nutrient removal (BNR) pilot plant to assess the performance of bio-P at progressively lower DO operation. This …

The Role Of Artificial Intelligence In Workforce Learning And Development: A Systematic Review, Mildred V. Jones

Educational Leadership & Workforce Development Theses & Dissertations

The purpose of this study is to investigate how artificial intelligence (AI) is currently employed in workforce learning and development. The study examined the types of AI employed and the affordances realized for organizations and employees. A PRISMA systematic review methodology was utilized to address the overarching problem statement and answer the three questions guiding the study. The PRISMA extension Preferred Reporting Items for Systematic Reviews and Meta Analysis for Protocols was used to direct each phase of the research. In addition, the Preferred Reporting Items for Systematic Reviews and Meta Analysis was used to conduct the article selection process. …

Development Of Flexible Lactate-Specific Molecularly Imprinted Polymers Based On Laser-Induced Graphene Electrochemical Biosensors For Disease Diagnosis, Christopher Animashaun

Biomedical Engineering Theses & Dissertations

Lactate is a critical biomarker linked to conditions such as sepsis, ischemia, cancer, and heart failure. Current lactate detection methods remain invasive, costly, and unsuitable for real-time, continuous monitoring. This study presents the development of a flexible, non-enzymatic electrochemical biosensor based on laser-induced graphene (LIG) electrodes modified with gold nanoparticles (AuNPs) and molecularly imprinted polymers (MIPs) for highly selective and sensitive lactate measurement. The integration of AuNPs enhanced surface conductivity and provided nanoscale heterogeneity, facilitating superior signal amplification. The optimized LIG/AuNP/MIP sensor achieved an extensive dynamic detection range from 0.1 μM to 1000 μM, with an outstanding detection limit of …

Semi-Parametric Testing For Ordinal Treatment Effects In Time-To-Event Data Via Dynamic Dirichlet Process Mixtures Of The Inverse-Gaussian Distribution., Jonathan A Race, Amy S Ruppert, Yvonne Efebera, Michael L Pennell

Ambulatory and Primary Care Articles

Time-to-event data often violate the proportional hazards assumption under which the log-rank test is optimal. Such violations are especially common in the sphere of biological and medical data where heterogeneity due to unmeasured covariates or time varying effects are common. A variety of parametric survival models have been proposed in the literature which make more appropriate assumptions on the hazard function, at least for certain applications. One such model is derived from the first hitting time paradigm which assumes that a subject's event time is determined by a latent stochastic process reaching a threshold value. Several random effects specifications of …

Science-Based Policy Recommendations For Managing Emerging Pollutants: Protecting Water Quality For The Health Of People And The Environment, Sarantuyaa Zandaryaa, Ali Fares, Gabriel Eckstein, Regina M. Buono, Mary Trudeau, James E. Nickum, Xingui Xia, Atikur Rahman, Marijn Korndewal, Cassiana C. Montagner, Piero R. Gardinali, Robert Michael Di Filippo, Anoop Veettil

Faculty Scholarship

Emerging water pollutants are a growing global concern due to their ubiquitous presence in water resources worldwide and their potential adverse effects on human health and ecosystems. Limited scientific understanding of sources of emerging pollutants’ emissions to water bodies and their pathways, behaviour, and fate in aquatic environments, as well as human health and ecological effects, is a significant hindrance in managing emerging water pollutants. With exceptions concerning PFAS/PFOS and microplastic beads, there are few regulations for emerging pollutants in national water and environmental policies, which results in a critical gap in safeguarding human health and aquatic ecosystems through effective …

A Formal Simulation Model For Discrete Rate Simulation, Thomas J. Tracey

Electrical & Computer Engineering Theses & Dissertations

Simulation is an essential tool for virtualizing systems by creating a representative model of real or hypothetical systems and observing how they change over time. Two predominant simulation paradigms include Discrete Event Simulation (DES) and Continuous Simulation, which both have their strengths and weaknesses. DES does not handle continuous state variables, while continuous simulation handles continuous state variables but encounters errors where these variables have discrete changes in their behavior. This difficulty between the two predominant simulation paradigms prompted the creation of a new simulation paradigm to cover this gap: Discrete Rate Simulation (DRS). DRS as a simulation paradigm focuses …

Discrimination And Adverse Birth Outcomes Among Latina Women: The Protective Role Of Social Support., Sabrina R. Liu, Kimberly D'Anna-Hernandez, Curt A. Sandman, Elysia Poggi Davis, Laura M. Glynn

Psychology Faculty Research and Publications

Interpersonal discrimination has been associated with adverse birth outcomes among Black populations, but few studies have examined the impact of discrimination among Latinx/Hispanic populations in the United States, especially in conjunction with resources that could be protective. The present study examined (a) if exposure to discrimination is associated with adverse birth outcomes for Latina/Hispanic women and (b) if prenatal social support buffers these links. Method: In two independent prospective studies of Latina/Hispanic women in Southern California (N = 84 and N = 102), the relation between maternal experience of discrimination and birth outcomes (length of gestation and birth weight) …

Antituberculosis Potential Of Borrelidin Derivatives: An In Silico Molecular Docking And Molecular Dynamic Approach, Teni Ernawati, Donny Ramadhan, Faris Hermawan, Sasmito Wulyoadi, Bambang Marwoto, Ahmad Wibisana, Bambang Srijanto

The Thai Journal of Pharmaceutical Sciences

Background: The present tuberculosis (TB) treatment requires a significant time commitment, often lasting from 6 months to 2 years, with strict daily adherence. Non-compliance leads to drug resistance and suboptimal outcomes. Present research indicates that borrelidin shows potential activity against Mycobacterium tuberculosis, including strains that are resistant to first-line medications. Borrelidin has shown remarkable activity against M. tuberculosis H37Rv, with a minimum inhibitory concentration value of 3.12 μg/mL. Therefore, investigating the inhibition activity of borrelidin derivatives was essential for finding new anti-TB candidates. Objectives: This study aims to investigate the effects of 31 borrelidin derivative compounds …

Preparation And Evaluation Of Mesoporous Celecoxib For Improved Antiarthritic Activity In Rodents, Reena I. Fernandaes, Sayani Bhattacharyya

The Thai Journal of Pharmaceutical Sciences

Background: Celecoxib, a model anti-inflammatory drug, used in the management of arthritis exhibits limited oral bioavailability and slow onset of action due to its poor solubility. Objective: The present study explores a mesoporous drug delivery of celecoxib to investigate the efficacy of its antiarthritic activity in animal models, and develops a low-oral dose therapy. Materials and Methods: The solvent evaporation method was employed for the preparation of mesoporous delivery of celecoxib, using Syloid^®, and Neusilin^®, at a molar ratio of silica/ drug 1:2.5. The formulations were characterized for drug loading, in vitro drug release, and material …

The Antioxidant And Antiaging Activity Of Fig (Ficus Carica Linn) Leaf Ethanolic Extract In Vitro, Aji Winanta, Novita Zulaekhah, Perdana Priya Haresmita, Annisa Krisridwany, Rifki Febriansah, Inka Aprissa

The Thai Journal of Pharmaceutical Sciences

Background: Human organ systems can experience the aging process, one of which is the aging of the skin, characterized by dry, rough, or scaly skin, dullness, dark spots, and wrinkles. Previous studies have found that fig leaves contain compounds that have the potential to be anti-aging.
Objectives: This study aimed to determine the potential of fig leaves (Ficus carica Linn) as an anti-aging agent by examining their antioxidant activity, elastase inhibition, and antioxidative stress activity against hydrogen peroxide (H₂O₂). Materials and Methods: The phytochemicals in fig leaf ethanol extract were identified using phytochemical screening tests, …

Enhancing Topical Drug Delivery Of Apremilast Through Niosomal Gel Formulation: Ex Vivo Skin Permeation And In Vivo Evaluation For Psoriasis, Megha Shyam Matlapudi, Anka Rao Areti, Yukti Jaiswal, Veeresh Bantal, Raghavender Medishetti

The Thai Journal of Pharmaceutical Sciences

Background: Psoriasis is a dynamic and chronic disease characterized by inflammatory changes and an increased rate of keratinocyte proliferation leading to the formation of erythematous scleroderma plaques with a silvery sheen. The existing therapies come with shortcomings in terms of effectiveness and leave behind a trail of side effects. Hence, there is a need of alternative therapeutic measures. Objectives: This study aimed to assess the therapeutic potential of Apremilast Niosomal Gel (APR Nio Gel) in treating psoriasis, comparing its effectiveness with conventional gel (APR Gel) and oral suspension (APR Oral) formulations. Materials and Methods: Apremilast niosomes were prepared by thin …

Introduction Of Clinical Pastoral Education In Ukraine: The Experience Of The Volyn Orthodox Theological Academy, Vladyslav Fulmes, Volodymyr Vakin, Oleksandr Khoroshko

Occasional Papers on Religion in Eastern Europe

Medical chaplaincy is an important component in many countries, as it helps to ensure a holistic approach to treatment, taking into account the spiritual needs of patients. The relevance of this direction was due to the invasion of russian troops on the territory of Ukraine back in 2014, and in the conditions of a full-scale war in Ukraine, the role of medical chaplaincy has increased significantly. This article reveals the experience of the Volyn Orthodox Theological Academy (Lutsk, Ukraine) in training medical chaplains, which was the first in Ukraine, responding to social challenges, in particular health care institutions, to develop …

Comparative Analysis Of Microflora Of Bread Flour And Secondary Raw Materials From Wheat Grain Stored In Open Warehouses, Oybek Sh. Mustafoev, Suvankul S. Ravshanov, Gulnoza Z. Djakhangirova

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the study is to conduct a comparative analysis of the microflora of bakery flour and secondary raw materials (bran) selected from batches of wheat grain stored in open warehouses. The article presents an analysis of microbiological contamination during storage and processing of wheat grain and its impact on finished products. According to the analysis, samples of bakery flour and secondary raw materials (bran) selected from groups of wheat grain stored in open warehouses showed higher microbiological contamination than samples selected from wheat stored in closed warehouses. It was found that the number of spore-forming bacteria in the …

Justification Of Permissible Discharges Of Water Users Into Water Bodies, Mariia S. Stroganova, Ivan V. Antonov, Andrey V. Epifanov

CHEMISTRY AND CHEMICAL ENGINEERING

The purpose of this work is developing an algorithm for ecological and technological rationing of the permissible load on water bodies using geoinformation systems. The algorithm takes into account the self-purification of aquatic ecosystems using a three-component model. Initially, the article provides an overview of methods for determining the permissible discharge masses of pollutants for developing new approaches to rationing. The algorithm of ecological and technological rationing of the load on water bodies and geoinformation systems for its implementation is proposed. The main models used to assess the ecological state of an aquatic ecosystem are considered. A three-component model of …

Synthesis Of Acetylene-Based Hetarene Derivatives In The Presence Of Catalysts, Abdulla T. Umrzokov, Abduvaxаb Ikramov, Khusnitdin M. Vapoev, Yusuf K. Zhumanov, Sardor M. Kodirov

CHEMISTRY AND CHEMICAL ENGINEERING

The aim of the study is to synthesize hetaren derivatives of acetylene amination reactions using local natural raw materials as catalyst carriers. Various grades of Oltintag and Angren kaolins, various grades of Navbakhor bentonite, as well as the opaque rock of the Karmaninsky deposit were used as catalyst carriers. Thermal, acidic and hydrothermal treatment was carried out on the appropriate sorbents, with the production of catalysts of various modifications from sorbents and active components. The processes of catalytic condensation of acetylene with ammonia were studied using modified catalysts. The effect of the reaction temperature, the active components of the catalyst, …

The Impact Of Emergency Haying On Grassland Birds In The Conservation Reserve Program Habitats Of Northwest Iowa, Claire Widmer, Ai Wen, Kenneth Elgersma, Mark Vandever

Research in the Capitol

Data was collected on breeding grassland bird communities in northwest Iowan Conservation Reserve Program (CRP) fields. Within those fields, CRP grasslands in drought areas could be hayed or grazed for emergency management to harvest supplemental forage for livestock. We compared the bird communities in emergency hayed versus undisturbed grasslands to understand how the drought induced emergency haying affected the grassland birds. Using distance sampling, we found that significantly higher bird richness was found in undisturbed habitat areas compared to the emergency managed hayed areas in the same CRP parcel. In addition, we found that bird density in the emergency managed …

Accessibility To Menstrual Products At The University Of Northern Iowa, Catrina Tounjian, Disa Cornish

Research in the Capitol

Period poverty is the inability to access menstrual products due to economic vulnerability. In the US, 1 in 5 menstruating students miss school due to period poverty. Educational disparities that derive from period poverty must be investigated. At the University of Northern Iowa (UNI), a student-led initiative aims to reduce academic barriers created by period poverty. Within one semester, nearly 3,000 tampons and 2,500 pads were distributed across 17 academic buildings. This study evaluates the impact of free menstrual products on campus by analyzing usage and student feedback, revealing a positive effect on academic attainability. However, the initiative's sustainability is …

A New Application Of The Coimbra Method For Cranial Entheseal Changes, Emily Carlo

Research in the Capitol

The study of entheseal changes (EC) has a lengthy history within biological anthropology, aiding in the reconstruction of habitual activities, lifestyles, and physiological stress experienced by past populations. However, most existing research has focused on postcranial entheses, leaving cranial entheses largely unexplored. This study aims to apply the Coimbra Method, a recent and standardized scoring system, to analyze cranial entheses and investigate the relationship between age, sex, and entheseal changes. By observing and scoring entheses associated with the insertions of five cranial muscles, this research will contribute to a deeper understanding of skeletal plasticity in response to mechanical stress. The …

19th Annual Research In The Capitol [Program], March 31, 2025, University Of Northern Iowa. University Honors Program. Iowa State University. Honors Program. University Of Iowa. Honors Program.

Research in the Capitol Programs

Program of research presentations given at the Capitol by students from the University of Northern Iowa, Iowa State University, and the University of Iowa.

Faculty Senate Meeting Agenda And Minutes, March 31, 2025

Faculty Senate Minutes and Agendas

Agenda and minutes from the Wright State University Faculty Senate Meeting held on, March 31, 2025.

Kedudukan Hukum Anak Bawaan Dalam Perkara Kepemilikan Hak Atas Tanah Dalam Perkawinan Campuran (Studi Putusan Nomor 280/Pdt.G/2021/Pn Btm), Rana Mahirah

Indonesian Notary

Pengurusan harta warisan yang melibatkan anak kandung dan pasangan kedua menimbulkan berbagai macam celah hukum jika tidak dilaksanakan sesuai dengan ketentuan yang berlaku, terutama jika perkawinan kedua tersebut merupakan perkawinan campuran yang harus lebih diperhatikan lagi ketentuan ketentuannya terkait harta dan bendanya yang dapat menimbulkan sengketa di kemudian hari. Penelitian ini membahas tentang kedudukan anak bawaan dalam perkawinan kedua orang tuanya dan peran dan tanggung jawab terhadap notaris dalam melakukan pengurusan harta waris, dengan mengangkat kasus dalam Putusan Nomor 280/Pdt.G/2021/PN Btm. Penelitian ini menerapkan metode penelitian doktrinal dengan tipe penelitian eksplanatoris. Hasil penelitian menunjukkan bahwa anak bawaan dari perkawinan sebelumnya …

Bird Richness As A Mediator Between Greenspace And Mental Health Relationships, Sihao Chena, Huaqing Wang, Wenyan Xu

Landscape Architecture and Environmental Planning Faculty Publications

Neighborhood greenspaces are widely known to benefit bird diversity and human mental health. However, whether bird richness mediates the relationship between greenspace and mental health is unknown. We ascertain such mediation effects in 294 census tracts in Los Angeles City. We obtained greenspace data from one-meter resolution satellite imagery, bird species data from eBird citizen science datasets, and prevalence of poor mental health from the US Centers for Disease Control and Prevention. Mediation analysis combined with spatial error models was used to assess the mediating effects while controlling for geographic, demographic, and socio-economic factors. We found that the higher greenspace …

Multiple Path Particle Dosimetry (Mppd) Model Total Dust Among Mineral Ore Processing Workers, Arif Susanto, Muhamad Rizky Yudhiantara, Edi Karyono Putro, Prayoga Kara, Anthony Andorful Manuel, Nurulia Hidayah

Media Kesehatan Masyarakat Indonesia

Mineral ore processing generates dust, which poses a significant health risk to workers due to prolonged exposure. The aerodynamic properties of this dust allow it to be inhaled and deposited deep within the respiratory tract, increasing the risk of impaired respiratory function. This study aimed to quantify and assess the health risk associated with respirable dust exposure among workers in mineral ore processing areas using the Multiple Path Particle Dosimetry (MPPD) Model. The MPPD model was used to estimate the deposition of dust particles in various regions of the respiratory tract. A constant scenario with the average respirable dust concentration …